{"id":840,"date":"2014-10-28T20:00:14","date_gmt":"2014-10-28T17:00:14","guid":{"rendered":"http:\/\/e-endocrinology.gr\/?page_id=840"},"modified":"2015-02-18T15:14:54","modified_gmt":"2015-02-18T12:14:54","slug":"10-27-%ce%b8%cf%85%cf%81%ce%b5%ce%bf%ce%b5%ce%b9%ce%b4%ce%ae%cf%82-%ce%ba%ce%b1%ce%b9-%cf%80%ce%b1%cf%87%cf%85%cf%83%ce%b1%cf%81%ce%ba%ce%af%ce%b1","status":"publish","type":"page","link":"https:\/\/e-endocrinology.gr\/?page_id=840","title":{"rendered":"10.27 \u0398\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03ae\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03b1\u03c7\u03c5\u03c3\u03b1\u03c1\u03ba\u03af\u03b1"},"content":{"rendered":"<p style=\"text-align: right;\"><div class=\"printfriendly pf-button  pf-alignright\">\n                    <a href=\"https:\/\/e-endocrinology.gr\/?page_id=840&#038;pfstyle=wp\" rel=\"nofollow\" onclick=\"\" title=\"Printer Friendly, PDF & Email\">\n                    <img decoding=\"async\" class=\"pf-button-img\" src=\"https:\/\/cdn.printfriendly.com\/buttons\/printfriendly-pdf-button-nobg.png\" alt=\"Print Friendly, PDF & Email\" style=\"width: 112px;height: 24px;\"  \/>\n                    <\/a>\n                <\/div><\/p>\n<p><br class=\"none\" \/><\/p>\n<p style=\"text-align: right;\"><em>\u039c. \u039c\u03b9\u03c7\u03b1\u03bb\u03ac\u03ba\u03b7<\/em><br \/>\n\u0395\u03c0\u03b9\u03bc\u03b5\u03bb\u03ae\u03c4\u03c1\u03b9\u03b1 \u0391\u2019, \u0395\u03bd\u03b4\u03bf\u03ba\u03c1\u03b9\u03bd\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03a4\u03bc\u03ae\u03bc\u03b1, \u03a0\u03b1\u03bd\u03b5\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03b9\u03b1\u03ba\u03ae \u03a0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae,<br \/>\n\u03a0\u03b1\u03bd\u03b5\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03b9\u03b1\u03ba\u03cc \u0393\u03b5\u03bd\u03b9\u03ba\u03cc \u039d\u03bf\u03c3\u03bf\u03ba\u03bf\u03bc\u03b5\u03af\u03bf \u03a0\u03b1\u03c4\u03c1\u03ce\u03bd<br \/>\n<em>\u0391.\u0393. \u0392\u03b1\u03b3\u03b5\u03bd\u03ac\u03ba\u03b7\u03c2<\/em><br \/>\n\u039f\u03bc\u03cc\u03c4\u03b9\u03bc\u03bf\u03c2 \u039a\u03b1\u03b8\u03b7\u03b3\u03b7\u03c4\u03ae\u03c2 \u0395\u03bd\u03b4\u03bf\u03ba\u03c1\u03b9\u03bd\u03bf\u03bb\u03bf\u03b3\u03af\u03b1\u03c2-\u03a0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03af\u03b1\u03c2 \u03a0\u03b1\u03bd\u03b5\u03c0\u03b9\u03c3\u03c4\u03ae\u03bc\u03b9\u03bf \u03a0\u03b1\u03c4\u03c1\u03ce\u03bd<b><br \/>\n<\/b><\/p>\n<p><b><br clear=\"all\" \/> <\/b><\/p>\n<h4 style=\"text-align: justify;\"><b>\u0395\u03b9\u03c3\u03b1\u03b3\u03c9\u03b3\u03ae<\/b><\/h4>\n<p style=\"text-align: justify;\">\u0397 \u03c0\u03b1\u03c7\u03c5\u03c3\u03b1\u03c1\u03ba\u03af\u03b1 \u03b1\u03bd\u03b1\u03c6\u03ad\u03c1\u03b5\u03c4\u03b1\u03b9 \u03c9\u03c2 \u03b7 \u03b5\u03c0\u03b9\u03b4\u03b7\u03bc\u03af\u03b1 \u03c4\u03b7\u03c2 \u03b5\u03c0\u03bf\u03c7\u03ae\u03c2 \u03bc\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bd\u03bf\u03b4\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03bd\u03bf\u03c3\u03b7\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03b8\u03bd\u03b7\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1 \u03bc\u03ad\u03c3\u03c9 \u03c4\u03c9\u03bd \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03ce\u03bd \u03c3\u03c5\u03bd-\u03bd\u03bf\u03c3\u03b7\u03c1\u03bf\u03c4\u03ae\u03c4\u03c9\u03bd \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af. \u0397 \u03c0\u03b1\u03c7\u03c5\u03c3\u03b1\u03c1\u03ba\u03af\u03b1 \u03bf\u03c6\u03b5\u03af\u03bb\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ac \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03c0\u03b5\u03c1\u03b9\u03b2\u03b1\u03bb\u03bb\u03bf\u03bd\u03c4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03b1\u03af\u03c4\u03b9\u03b1. \u0397 \u03bf\u03bc\u03bf\u03b9\u03bf\u03c3\u03c4\u03b1\u03c3\u03af\u03b1 \u03c4\u03b7\u03c2 \u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b1\u03c2 \u03b4\u03b9\u03ad\u03c0\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c0\u03bf\u03bb\u03cd\u03c0\u03bb\u03bf\u03ba\u03bf\u03c5\u03c2 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03cd\u03c2 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03bf\u03c0\u03bf\u03af\u03bf\u03c5\u03c2 \u03b5\u03bd\u03ad\u03c7\u03b5\u03c4\u03b1\u03b9 \u03c4\u03bf \u03ba\u03b5\u03bd\u03c4\u03c1\u03b9\u03ba\u03cc \u03bd\u03b5\u03c5\u03c1\u03b9\u03ba\u03cc \u03ba\u03b1\u03b9 \u03b3\u03b1\u03c3\u03c4\u03c1\u03b5\u03bd\u03c4\u03b5\u03c1\u03b9\u03ba\u03cc \u03c3\u03cd\u03c3\u03c4\u03b7\u03bc\u03b1, \u03bf \u03b5\u03bd\u03b4\u03b9\u03ac\u03bc\u03b5\u03c3\u03bf\u03c2 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03c3\u03bc\u03cc\u03c2, \u03b7 \u03b8\u03b5\u03c1\u03bc\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7, \u03bf \u03bb\u03b9\u03c0\u03ce\u03b4\u03b7\u03c2 \u03b9\u03c3\u03c4\u03cc\u03c2 \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03b5\u03bd\u03b4\u03bf\u03ba\u03c1\u03b9\u03bd\u03b9\u03ba\u03bf\u03af \u03ac\u03be\u03bf\u03bd\u03b5\u03c2. \u0397 \u03c3\u03c7\u03ad\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b5\u03ba\u03b4\u03ae\u03bb\u03c9\u03c3\u03b7 \u03c0\u03b1\u03c7\u03c5\u03c3\u03b1\u03c1\u03ba\u03af\u03b1\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03bf\u03bb\u03c5\u03c3\u03c5\u03b6\u03b7\u03c4\u03b7\u03bc\u03ad\u03bd\u03b7 \u03ba\u03b1\u03b8\u03ce\u03c2 \u03b7 \u03a4<sub>3<\/sub> \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b8\u03b5\u03c1\u03bc\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7, \u03b5\u03bd\u03ad\u03c7\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03c1\u03cd\u03b8\u03bc\u03b9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03cc\u03c1\u03b5\u03be\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03bf \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03c3\u03bc\u03cc \u03c4\u03c9\u03bd \u03bb\u03b9\u03c0\u03ce\u03bd \u03ba\u03b1\u03b9 \u03c5\u03b4\u03b1\u03c4\u03b1\u03bd\u03b8\u03c1\u03ac\u03ba\u03c9\u03bd. \u039c\u03ad\u03c7\u03c1\u03b9 \u03c3\u03ae\u03bc\u03b5\u03c1\u03b1 \u03cc\u03bc\u03c9\u03c2 \u03b4\u03b5\u03bd \u03ad\u03c7\u03b5\u03b9 \u03b1\u03c0\u03bf\u03b4\u03b5\u03b9\u03c7\u03b8\u03b5\u03af \u03b5\u03ac\u03bd \u03b7 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae \u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03c3\u03c5\u03bc\u03b2\u03ac\u03bb\u03bb\u03b5\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b5\u03ba\u03b4\u03ae\u03bb\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c0\u03b1\u03c7\u03c5\u03c3\u03b1\u03c1\u03ba\u03af\u03b1\u03c2 \u03ae \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03bc\u03b9\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03b5\u03c0\u03b9\u03c0\u03bb\u03bf\u03ba\u03ad\u03c2 \u03c4\u03b7\u03c2 \u03ae \u03ba\u03b1\u03b9 \u03af\u03c3\u03c9\u03c2 \u03b1\u03ba\u03cc\u03bc\u03b7 \u03b1\u03bd\u03c4\u03b9\u03c1\u03c1\u03bf\u03c0\u03b9\u03c3\u03c4\u03b9\u03ba\u03cc \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc.<\/p>\n<h4 style=\"text-align: justify;\"><b>1. \u0397 \u03a43 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03ba\u03b1\u03c4\u03b1\u03bd\u03ac\u03bb\u03c9\u03c3\u03b7 \u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b1\u03c2<\/b><\/h4>\n<p style=\"text-align: justify;\">\u0389\u03c4\u03b1\u03bd \u03b3\u03bd\u03c9\u03c3\u03c4\u03cc \u03b1\u03c0\u03cc \u03c0\u03bf\u03bb\u03cd \u03c0\u03b1\u03bb\u03b9\u03ac \u03cc\u03c4\u03b9 \u03bf \u03c5\u03c0\u03b5\u03c1\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03c3\u03bc\u03cc\u03c2 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03ba\u03b1\u03c4\u03b1\u03bd\u03ac\u03bb\u03c9\u03c3\u03b7 \u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b1\u03c2, \u03cc\u03bc\u03c9\u03c2 \u03bf\u03b9 \u03c5\u03c0\u03b5\u03cd\u03b8\u03c5\u03bd\u03bf\u03b9 \u03c0\u03b1\u03b8\u03bf\u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03bf\u03af \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03af \u03b1\u03c0\u03bf\u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c4\u03b1 \u03c4\u03b5\u03bb\u03b5\u03c5\u03c4\u03b1\u03af\u03b1 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 (1). \u039f \u03bf\u03c1\u03b3\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2 \u03ba\u03b1\u03b8\u03b7\u03bc\u03b5\u03c1\u03b9\u03bd\u03ac \u03be\u03bf\u03b4\u03b5\u03cd\u03b5\u03b9 \u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03b2\u03b1\u03c3\u03b9\u03ba\u03cc \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03ba\u03cc \u03c1\u03c5\u03b8\u03bc\u03cc (\u03ae \u03c5\u03c0\u03bf\u03c7\u03c1\u03b5\u03c9\u03c4\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03bc\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7-obligatory thermogenesis: \u03b7 \u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b1 \u03c0\u03bf\u03c5 \u03ba\u03b1\u03c4\u03b1\u03bd\u03b1\u03bb\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b4\u03b9\u03b1\u03c4\u03ae\u03c1\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2 \u03c4\u03c9\u03bd \u03bf\u03c1\u03b3\u03ac\u03bd\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c4\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c4\u03bf\u03c5 \u03bf\u03c1\u03b3\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03cd \u03c3\u03b5 \u03b7\u03c1\u03b5\u03bc\u03af\u03b1 \u03c3\u03b5 \u03b8\u03b5\u03c1\u03bc\u03bf\u03bf\u03c5\u03b4\u03ad\u03c4\u03b5\u03c1\u03b7 \u03b8\u03b5\u03c1\u03bc\u03bf\u03ba\u03c1\u03b1\u03c3\u03af\u03b1, \u03b4\u03b7\u03bb\u03b1\u03b4\u03ae \u03c0\u03b5\u03c1\u03af \u03c4\u03bf\u03c5\u03c2 28<sup>\u03bf<\/sup>C \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03ac\u03bd\u03b8\u03c1\u03c9\u03c0\u03bf), \u03c4\u03b7\u03bd \u03c6\u03c5\u03c3\u03b9\u03ba\u03ae \u03b4\u03c1\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 (exercise \u03ba\u03b1\u03b9 non-exercise physical activity) \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03c0\u03c1\u03bf\u03c3\u03b1\u03c1\u03bc\u03bf\u03c3\u03c4\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03bc\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7 (adaptive thermogenesis, \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03b7\u03c2 \u03bb\u03ae\u03c8\u03b7\u03c2 \u03c4\u03c1\u03bf\u03c6\u03ae\u03c2 \u03ba\u03b1\u03b9 \u03ad\u03ba\u03b8\u03b5\u03c3\u03b7\u03c2 \u03c3\u03c4\u03bf \u03c8\u03cd\u03c7\u03bf\u03c2) (<b>\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 1<\/b>) (2,3). \u0397 \u03a43 \u03b1\u03c6\u03b5\u03bd\u03cc\u03c2 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03b9\u03c2 \u03b1\u03bd\u03ac\u03b3\u03ba\u03b5\u03c2 \u03c4\u03bf\u03c5 \u03bf\u03c1\u03b3\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03cd \u03c3\u03b5 ATP \u03ba\u03b1\u03b9 \u03b1\u03c6\u03b5\u03c4\u03ad\u03c1\u03bf\u03c5 \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b8\u03b5\u03c1\u03bc\u03bf\u03b4\u03c5\u03bd\u03b1\u03bc\u03b9\u03ba\u03ae \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03c3\u03cd\u03bd\u03b8\u03b5\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5, \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03bd\u03b1 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03cc\u03c3\u03bf \u03c4\u03b7\u03bd \u03c5\u03c0\u03bf\u03c7\u03c1\u03b5\u03c9\u03c4\u03b9\u03ba\u03ae \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03c0\u03c1\u03bf\u03c3\u03b1\u03c1\u03bc\u03bf\u03c3\u03c4\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03bc\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7.<\/p>\n<hr style=\"width: 100%; border-width: 1px; border-style: solid; border-color: #CCCCCC; color: #ffffff;\" noshade=\"noshade\" width=\"100%\" \/>\n<p style=\"text-align: justify;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-841\" alt=\"10.27-figure1\" src=\"https:\/\/e-endocrinology.gr\/wp-content\/uploads\/2014\/10\/10.27-figure1.jpg\" width=\"504\" height=\"581\" srcset=\"https:\/\/e-endocrinology.gr\/wp-content\/uploads\/2014\/10\/10.27-figure1.jpg 504w, https:\/\/e-endocrinology.gr\/wp-content\/uploads\/2014\/10\/10.27-figure1-260x300.jpg 260w\" sizes=\"(max-width: 504px) 100vw, 504px\" \/><\/p>\n<p style=\"text-align: justify;\">\u00a0<b><br \/>\n<\/b><\/p>\n<p style=\"text-align: justify;\"><b><em>\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 1<\/em>.<\/b> \u0394\u03b9\u03b1\u03c7\u03b5\u03af\u03c1\u03b9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c0\u03c1\u03bf\u03c3\u03bb\u03b1\u03bc\u03b2\u03b1\u03bd\u03bf\u03bc\u03ad\u03bd\u03b7\u03c2 \u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b1\u03c2 (\u03c4\u03c1\u03bf\u03c6\u03ae\u03c2) \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd \u03ac\u03bd\u03b8\u03c1\u03c9\u03c0\u03bf (2).<\/p>\n<hr style=\"width: 100%; border-width: 1px; border-style: solid; border-color: #CCCCCC; color: #ffffff;\" noshade=\"noshade\" width=\"100%\" \/>\n<p style=\"text-align: justify;\">\n<p style=\"text-align: justify;\">\u0397 \u03a43 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03b9\u03c2 \u03b1\u03bd\u03ac\u03b3\u03ba\u03b5\u03c2 \u03c4\u03bf\u03c5 \u03bf\u03c1\u03b3\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03cd \u03c3\u03b5 \u0391\u03a4\u03a1 \u03bc\u03b5 \u03c4\u03bf\u03c5\u03c2 \u03ba\u03ac\u03c4\u03c9\u03b8\u03b9 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03cd\u03c2 (4):<\/p>\n<ul>\n<li>\u0391\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b4\u03b9\u03b1\u03c0\u03b5\u03c1\u03b1\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae\u03c2 \u03bc\u03b5\u03bc\u03b2\u03c1\u03ac\u03bd\u03b7\u03c2 \u03c3\u03c4\u03b1 \u03b9\u03cc\u03bd\u03c4\u03b1 \u03bd\u03b1\u03c4\u03c1\u03af\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03ba\u03b1\u03bb\u03af\u03bf\u03c5 \u03b5\u03be\u03b1\u03bd\u03b1\u03b3\u03ba\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7\u03bd \u03b1\u03bd\u03c4\u03bb\u03af\u03b1 \u039d\u03b1-\u039a-ATPase \u03bd\u03b1 \u03c5\u03c0\u03b5\u03c1\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b5\u03af \u03ba\u03b1\u03b9 \u03b5\u03c0\u03bf\u03bc\u03ad\u03bd\u03c9\u03c2 \u03bd\u03b1 \u03be\u03bf\u03b4\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b7 \u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b1 \u03c0\u03c1\u03bf\u03ba\u03b5\u03b9\u03bc\u03ad\u03bd\u03bf\u03c5 \u03bd\u03b1 \u03b5\u03c0\u03b1\u03bd\u03b1\u03c6\u03ad\u03c1\u03b5\u03b9 \u03c4\u03bf \u03ba\u03ac\u03bb\u03b9\u03bf \u03b5\u03bd\u03b4\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03bf \u03bd\u03ac\u03c4\u03c1\u03b9\u03bf \u03b5\u03be\u03c9\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03b9\u03b1. \u0395\u03c0\u03af\u03c3\u03b7\u03c2 \u03b7 \u03a43 \u03b5\u03c0\u03ac\u03b3\u03b5\u03b9 \u03c4\u03b7\u03bd \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03bd\u03c4\u03bb\u03af\u03b1\u03c2 \u039d\u03b1-\u039a-ATPase.<\/li>\n<li>\u0397 \u03a43 \u03b5\u03c0\u03ac\u03b3\u03b5\u03b9 \u03c4\u03b7\u03bd \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03b7\u03c2 SERCA1 \u03ba\u03b1\u03b9 \u03c4\u03c9\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03c9\u03bd \u03c1\u03c5\u03b1\u03bd\u03bf\u03b4\u03af\u03bd\u03b7\u03c2 \u03c3\u03c4\u03bf \u03c3\u03ba\u03b5\u03bb\u03b5\u03c4\u03b9\u03ba\u03cc \u03ba\u03b1\u03b9 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03ba\u03cc \u03bc\u03c5. \u0397 SERCA \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03b1\u03bd\u03c4\u03bb\u03af\u03b1 \u0391\u03a4\u03a1 \u03b5\u03be\u03b1\u03c1\u03c4\u03c9\u03bc\u03ad\u03bd\u03b7 \u03c3\u03c4\u03bf \u03c3\u03b1\u03c1\u03ba\u03bf\u03c0\u03bb\u03b1\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc \u03b4\u03af\u03ba\u03c4\u03c5\u03bf \u03c0\u03bf\u03c5 \u03bc\u03b5\u03c4\u03b1\u03c6\u03ad\u03c1\u03b5\u03b9 \u03b9\u03cc\u03bd\u03c4\u03b1 \u03b1\u03c3\u03b2\u03b5\u03c3\u03c4\u03af\u03bf\u03c5 \u03b1\u03c0\u03cc \u03c4\u03bf \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03cc\u03c0\u03bb\u03b1\u03c3\u03bc\u03b1 \u03c3\u03c4\u03bf \u03c3\u03b1\u03c1\u03ba\u03bf\u03c0\u03bb\u03b1\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc \u03b4\u03af\u03ba\u03c4\u03c5\u03bf. \u039f\u03b9 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03b5\u03af\u03c2 \u03c1\u03c5\u03b1\u03bd\u03bf\u03b4\u03af\u03bd\u03b7\u03c2 \u03b2\u03c1\u03af\u03c3\u03ba\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03bc\u03b5\u03bc\u03b2\u03c1\u03ac\u03bd\u03b7 \u03c4\u03bf\u03c5 \u03c3\u03b1\u03c1\u03ba\u03bf\u03c0\u03bb\u03b1\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03bf\u03cd \u03b4\u03b9\u03ba\u03c4\u03cd\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03bf\u03c5\u03c3\u03b9\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03b5\u03af\u03bd\u03b1\u03b9 \u03b4\u03af\u03b1\u03c5\u03bb\u03bf\u03b9 \u03b1\u03c3\u03b2\u03b5\u03c3\u03c4\u03af\u03bf\u03c5 \u03c0\u03bf\u03c5 \u03b5\u03c0\u03b9\u03c4\u03c1\u03ad\u03c0\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03c0\u03b1\u03b8\u03b7\u03c4\u03b9\u03ba\u03ae \u03b4\u03b9\u03ac\u03c7\u03c5\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b1\u03c3\u03b2\u03b5\u03c3\u03c4\u03af\u03bf\u03c5 \u03b1\u03c0\u03cc \u03c4\u03bf \u03c3\u03b1\u03c1\u03ba\u03bf\u03c0\u03bb\u03b1\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc \u03b4\u03af\u03ba\u03c4\u03c5\u03bf \u03c3\u03c4\u03bf \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03cc\u03c0\u03bb\u03b1\u03c3\u03bc\u03b1.<\/li>\n<li>\u0395\u03c0\u03ac\u03b3\u03b5\u03b9 \u03ac\u03c3\u03ba\u03bf\u03c0\u03bf\u03c5\u03c2 \u03b1\u03bd\u03c4\u03b9\u03c6\u03b1\u03c4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03ba\u03cd\u03ba\u03bb\u03bf\u03c5\u03c2, \u03c0.\u03c7. \u03bb\u03b9\u03c0\u03cc\u03bb\u03c5\u03c3\u03b7-\u03bb\u03b9\u03c0\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7, \u03c0\u03c1\u03c9\u03c4\u03b5\u03cc\u03bb\u03c5\u03c3\u03b7-\u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03bf\u03c3\u03cd\u03bd\u03b8\u03b5\u03c3\u03b7, \u03b3\u03bb\u03c5\u03ba\u03bf\u03bd\u03b5\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7-\u03bf\u03be\u03b5\u03af\u03b4\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b3\u03bb\u03c5\u03ba\u03cc\u03b6\u03b7\u03c2, \u03ba\u03b1\u03b9 \u03b5\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03ba\u03ae \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03c6\u03c5\u03c3\u03b9\u03ba\u03ae \u03b4\u03c1\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 (non-exercise physical activity).<\/li>\n<\/ul>\n<p style=\"text-align: justify;\">\u0397 \u03a43 \u03ba\u03b1\u03b9 \u03bf\u03b9 \u03ba\u03b1\u03c4\u03b5\u03c7\u03bf\u03bb\u03b1\u03bc\u03af\u03bd\u03b5\u03c2 \u03bc\u03ad\u03c3\u03c9 \u03c4\u03c9\u03bd \u03b23-\u03b1\u03b4\u03c1\u03b5\u03bd\u03b5\u03c1\u03b3\u03b9\u03ba\u03ce\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03c9\u03bd \u03b1\u03c5\u03be\u03ac\u03bd\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03c0\u03c1\u03bf\u03c3\u03b1\u03c1\u03bc\u03bf\u03c3\u03c4\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03bc\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7 \u03c3\u03c4\u03bf \u03c6\u03b1\u03b9\u03cc \u03bb\u03b9\u03c0\u03ce\u03b4\u03b7 \u03b9\u03c3\u03c4\u03cc \u03ba\u03b1\u03b9 \u03af\u03c3\u03c9\u03c2 \u03c3\u03b5 \u03ac\u03bb\u03bb\u03bf\u03c5\u03c2 \u03b9\u03c3\u03c4\u03bf\u03cd\u03c2, \u03cc\u03c0\u03c9\u03c2 \u03c3\u03c4\u03bf\u03bd \u03c3\u03ba\u03b5\u03bb\u03b5\u03c4\u03b9\u03ba\u03cc \u03bc\u03c5 (2). \u0397 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c0\u03c1\u03bf\u03c3\u03b1\u03c1\u03bc\u03bf\u03c3\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b8\u03b5\u03c1\u03bc\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7\u03c2 \u03b5\u03c0\u03b9\u03c4\u03c5\u03b3\u03c7\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03ad\u03c3\u03c9 \u03c4\u03b7\u03c2 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03b8\u03b5\u03c1\u03bc\u03bf\u03b4\u03c5\u03bd\u03b1\u03bc\u03b9\u03ba\u03ae\u03c2 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c4\u03b7\u03c2 \u03c3\u03cd\u03bd\u03b8\u03b5\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 ATP \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7\u03bd \u03bf\u03be\u03b5\u03b9\u03b4\u03c9\u03c4\u03b9\u03ba\u03ae \u03c6\u03c9\u03c3\u03c6\u03bf\u03c1\u03c5\u03bb\u03af\u03c9\u03c3\u03b7 \u03c3\u03c4\u03b1 \u03bc\u03b9\u03c4\u03bf\u03c7\u03cc\u03bd\u03b4\u03c1\u03b9\u03b1. \u039c\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c3\u03b5 \u03c0\u03b5\u03b9\u03c1\u03b1\u03bc\u03b1\u03c4\u03cc\u03b6\u03c9\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b4\u03b5\u03af\u03be\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03c4\u03cc\u03c3\u03bf \u03b7 \u03a43 \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03bf\u03b9 \u03ba\u03b1\u03c4\u03b5\u03c7\u03bf\u03bb\u03b1\u03bc\u03af\u03bd\u03b5\u03c2 \u03b1\u03c5\u03be\u03ac\u03bd\u03bf\u03c5\u03bd \u03c4\u03bf\u03bd \u03b1\u03c1\u03b9\u03b8\u03bc\u03cc \u03c4\u03c9\u03bd \u03bc\u03b9\u03c4\u03bf\u03c7\u03bf\u03bd\u03b4\u03c1\u03af\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03c0\u03bf\u03c3\u03c5\u03b6\u03b5\u03c5\u03ba\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03b7\u03c2 1 (uncoupling protein, UCP1) \u03c3\u03c4\u03b7\u03bd \u03b5\u03c3\u03c9\u03c4\u03b5\u03c1\u03b9\u03ba\u03ae \u03bc\u03b5\u03bc\u03b2\u03c1\u03ac\u03bd\u03b7 \u03c4\u03c9\u03bd \u03bc\u03b9\u03c4\u03bf\u03c7\u03bf\u03bd\u03b4\u03c1\u03af\u03c9\u03bd \u03c3\u03c4\u03b1 \u03bb\u03b9\u03c0\u03bf\u03ba\u03cd\u03c4\u03b1\u03c1\u03b1 \u03c4\u03bf\u03c5 \u03c6\u03b1\u03b9\u03bf\u03cd \u03bb\u03af\u03c0\u03bf\u03c5\u03c2 (<b>\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 2<\/b>) (1,2). \u039f\u03b9 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2 \u03b1\u03c0\u03bf\u03c3\u03cd\u03b6\u03b5\u03c5\u03be\u03b7\u03c2 \u03b2\u03c1\u03af\u03c3\u03ba\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c3\u03c9\u03c4\u03b5\u03c1\u03b9\u03ba\u03ae \u03bc\u03b5\u03bc\u03b2\u03c1\u03ac\u03bd\u03b7 \u03c4\u03c9\u03bd \u03bc\u03b9\u03c4\u03bf\u03c7\u03bf\u03bd\u03b4\u03c1\u03af\u03c9\u03bd \u03ba\u03b1\u03b9 \u03bf\u03c5\u03c3\u03b9\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03b5\u03af\u03bd\u03b1\u03b9 \u03b4\u03af\u03b1\u03c5\u03bb\u03bf\u03b9 \u03c0\u03c1\u03c9\u03c4\u03bf\u03bd\u03af\u03c9\u03bd. \u03a4\u03bf \u03c1\u03b5\u03cd\u03bc\u03b1 \u03c4\u03c9\u03bd \u03c0\u03c1\u03c9\u03c4\u03bf\u03bd\u03af\u03c9\u03bd \u03b1\u03c0\u03cc \u03c4\u03bf \u03b4\u03b9\u03b1\u03bc\u03b5\u03bc\u03b2\u03c1\u03b1\u03bd\u03b9\u03ba\u03cc \u03c7\u03ce\u03c1\u03bf \u03c0\u03c1\u03bf\u03c2 \u03c4\u03bf \u03b5\u03c3\u03c9\u03c4\u03b5\u03c1\u03b9\u03ba\u03cc \u03c4\u03bf\u03c5 \u03bc\u03b9\u03c4\u03bf\u03c7\u03bf\u03bd\u03b4\u03c1\u03af\u03bf\u03c5 \u03b4\u03b9\u03ad\u03c1\u03c7\u03b5\u03c4\u03b1\u03b9 \u03b4\u03b9\u03b1\u03bc\u03ad\u03c3\u03bf\u03c5 \u03c4\u03b7\u03c2 \u03b1\u03c0\u03bf\u03c3\u03c5\u03b6\u03b5\u03c5\u03ba\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2, \u03c0\u03b1\u03c1\u03b1\u03ba\u03ac\u03bc\u03c0\u03c4\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7\u03bd \u0391\u03a4\u03a1 \u03c3\u03c5\u03bd\u03b8\u03b5\u03c4\u03ac\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03ad\u03c4\u03c3\u03b9 \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u0391\u03a4\u03a1 \u03ba\u03b1\u03b9 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03b7 \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03b8\u03b5\u03c1\u03bc\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 (<b>\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 3<\/b>) (1,2). \u039c\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c3\u03b5 \u03c0\u03b5\u03b9\u03c1\u03b1\u03bc\u03b1\u03c4\u03cc\u03b6\u03c9\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b4\u03b5\u03af\u03be\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03bf \u03c5\u03c0\u03b5\u03c1\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03c3\u03bc\u03cc\u03c2 \u03b4\u03b9\u03b5\u03b3\u03b5\u03af\u03c1\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b8\u03b5\u03c1\u03bc\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7 \u03c3\u03c4\u03bf \u03c6\u03b1\u03b9\u03cc \u03bb\u03b9\u03c0\u03ce\u03b4\u03b7 \u03b9\u03c3\u03c4\u03cc \u03ba\u03b1\u03b9 \u03ad\u03bc\u03bc\u03b5\u03c3\u03b1 \u03bc\u03ad\u03c3\u03c9 \u03ba\u03b5\u03bd\u03c4\u03c1\u03b9\u03ba\u03ae\u03c2 \u03b4\u03b9\u03ad\u03b3\u03b5\u03c1\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bc\u03c0\u03b1\u03b8\u03b7\u03c4\u03b9\u03ba\u03bf\u03cd \u03bd\u03b5\u03c5\u03c1\u03b9\u03ba\u03bf\u03cd \u03c3\u03c5\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2 (<b>\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 4<\/b>) (5,6). \u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03b7 \u03ba\u03b5\u03bd\u03c4\u03c1\u03b9\u03ba\u03ae \u03b4\u03b9\u03ad\u03b3\u03b5\u03c1\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bc\u03c0\u03b1\u03b8\u03b7\u03c4\u03b9\u03ba\u03bf\u03cd \u03bd\u03b5\u03c5\u03c1\u03b9\u03ba\u03bf\u03cd \u03c3\u03c5\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c3\u03c4\u03bf\u03bd \u03c5\u03c0\u03b5\u03c1\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03c3\u03bc\u03cc \u03b4\u03b5\u03bd \u03ad\u03c7\u03b5\u03b9 \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03b9\u03c9\u03b8\u03b5\u03af \u03c3\u03b5 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03bf\u03c5\u03c2 (7). \u039f\u03b9 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03af \u03bc\u03b5 \u03c4\u03bf\u03c5\u03c2 \u03bf\u03c0\u03bf\u03af\u03bf\u03c5\u03c2 \u03b7 \u03a43 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03b7 \u03b8\u03b5\u03c1\u03bc\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7 \u03c3\u03b5 \u03ac\u03bb\u03bb\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03b1\u03bb\u03ac \u03b4\u03b9\u03b5\u03c5\u03ba\u03c1\u03b9\u03bd\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03b9, \u03c0\u03b9\u03b8\u03b1\u03bd\u03ac \u03b7 \u03a43 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b2\u03b1\u03c3\u03b9\u03ba\u03ae \u03b4\u03b9\u03b1\u03c1\u03c1\u03bf\u03ae \u03c4\u03c9\u03bd \u03c0\u03c1\u03c9\u03c4\u03bf\u03bd\u03af\u03c9\u03bd (basal proton leak) \u03ba\u03b1\u03b9 \u03b5\u03c0\u03ac\u03b3\u03b5\u03b9 \u03ac\u03bb\u03bb\u03b5\u03c2 \u03b1\u03c0\u03bf\u03c3\u03c5\u03b6\u03b5\u03c5\u03ba\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2 (1).<\/p>\n<hr style=\"width: 100%; border-width: 1px; border-style: solid; border-color: #CCCCCC; color: #ffffff;\" noshade=\"noshade\" width=\"100%\" \/>\n<p style=\"text-align: justify;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-842\" alt=\"10.27-figure2\" src=\"https:\/\/e-endocrinology.gr\/wp-content\/uploads\/2014\/10\/10.27-figure2.jpg\" width=\"650\" height=\"467\" srcset=\"https:\/\/e-endocrinology.gr\/wp-content\/uploads\/2014\/10\/10.27-figure2.jpg 650w, https:\/\/e-endocrinology.gr\/wp-content\/uploads\/2014\/10\/10.27-figure2-300x215.jpg 300w, https:\/\/e-endocrinology.gr\/wp-content\/uploads\/2014\/10\/10.27-figure2-624x448.jpg 624w\" sizes=\"(max-width: 650px) 100vw, 650px\" \/><\/p>\n<p style=\"text-align: justify;\">\n<p style=\"text-align: justify;\"><em><strong>\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 2.<\/strong><\/em> \u03a3\u03c5\u03bd\u03b5\u03c1\u03b3\u03b9\u03ba\u03ae \u03b4\u03c1\u03ac\u03c3\u03b7 \u03c4\u03c9\u03bd \u03ba\u03b1\u03c4\u03b5\u03c7\u03bf\u03bb\u03b1\u03bc\u03b9\u03bd\u03ce\u03bd \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03a43 \u03c3\u03c4\u03b7\u03bd \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03b7\u03c2 UCP-1 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03bc\u03b9\u03c4\u03bf\u03c7\u03bf\u03bd\u03b4\u03c1\u03b9\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7\u03c2 \u03c3\u03c4\u03bf \u03c6\u03b1\u03b9\u03cc \u03bb\u03b9\u03c0\u03ce\u03b4\u03b7 \u03b9\u03c3\u03c4\u03cc (2).<\/p>\n<hr style=\"width: 100%; border-width: 1px; border-style: solid; border-color: #CCCCCC; color: #ffffff;\" noshade=\"noshade\" width=\"100%\" \/>\n<p style=\"text-align: justify;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-843\" alt=\"10.27-figure3\" src=\"https:\/\/e-endocrinology.gr\/wp-content\/uploads\/2014\/10\/10.27-figure3.jpg\" width=\"650\" height=\"756\" srcset=\"https:\/\/e-endocrinology.gr\/wp-content\/uploads\/2014\/10\/10.27-figure3.jpg 650w, https:\/\/e-endocrinology.gr\/wp-content\/uploads\/2014\/10\/10.27-figure3-257x300.jpg 257w, https:\/\/e-endocrinology.gr\/wp-content\/uploads\/2014\/10\/10.27-figure3-624x725.jpg 624w\" sizes=\"(max-width: 650px) 100vw, 650px\" \/><\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: justify;\"><em><b>\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 3.<\/b><\/em> \u039c\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03c3\u03bc\u03cc\u03c2 \u03c4\u03b7\u03c2 \u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b1\u03c2 \u03c3\u03c4\u03b1 \u03bc\u03b9\u03c4\u03bf\u03c7\u03cc\u03bd\u03b4\u03c1\u03b9\u03b1. \u039f\u03be\u03b5\u03b9\u03b4\u03c9\u03c4\u03b9\u03ba\u03ae \u03c6\u03c9\u03c3\u03c6\u03bf\u03c1\u03c5\u03bb\u03af\u03c9\u03c3\u03b7 \u2013\u039c\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b8\u03b5\u03c1\u03bc\u03bf\u03b4\u03c5\u03bd\u03b1\u03bc\u03b9\u03ba\u03ae\u03c2 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c4\u03b7\u03c2 \u03c3\u03cd\u03bd\u03b8\u03b5\u03c3\u03b7\u03c2 \u0391\u03a4\u03a1\u00a0 (1,2).<\/p>\n<hr style=\"width: 100%; border-width: 1px; border-style: solid; border-color: #CCCCCC; color: #ffffff;\" noshade=\"noshade\" width=\"100%\" \/>\n<p style=\"text-align: justify;\"><a href=\"https:\/\/e-endocrinology.gr\/wp-content\/uploads\/2014\/10\/10.27-figure4.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-844\" alt=\"10.27-figure4\" src=\"https:\/\/e-endocrinology.gr\/wp-content\/uploads\/2014\/10\/10.27-figure4.jpg\" width=\"650\" height=\"624\" srcset=\"https:\/\/e-endocrinology.gr\/wp-content\/uploads\/2014\/10\/10.27-figure4.jpg 650w, https:\/\/e-endocrinology.gr\/wp-content\/uploads\/2014\/10\/10.27-figure4-300x288.jpg 300w, https:\/\/e-endocrinology.gr\/wp-content\/uploads\/2014\/10\/10.27-figure4-624x599.jpg 624w\" sizes=\"(max-width: 650px) 100vw, 650px\" \/><\/a><\/p>\n<p style=\"text-align: justify;\">\n<p style=\"text-align: justify;\"><em><strong>\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 4.<\/strong><\/em> \u0391\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b8\u03b5\u03c1\u03bc\u03bf\u03b3\u03b5\u03bd\u03ad\u03c3\u03b7\u03c2 \u03c3\u03c4\u03bf \u03c6\u03b1\u03b9\u03cc \u03bb\u03b9\u03c0\u03ce\u03b4\u03b7 \u03b9\u03c3\u03c4\u03cc \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03a43 \u03bc\u03ad\u03c3\u03c9 \u03ba\u03b5\u03bd\u03c4\u03c1\u03b9\u03ba\u03ae\u03c2 \u03b4\u03b9\u03ad\u03b3\u03b5\u03c1\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bc\u03c0\u03b1\u03b8\u03b7\u03c4\u03b9\u03ba\u03bf\u03cd \u03bd\u03b5\u03c5\u03c1\u03b9\u03ba\u03bf\u03cd \u03c3\u03c5\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c3\u03b5 \u03c4\u03c1\u03c9\u03ba\u03c4\u03b9\u03ba\u03ac (6).<\/p>\n<hr style=\"width: 100%; border-width: 1px; border-style: solid; border-color: #CCCCCC; color: #ffffff;\" noshade=\"noshade\" width=\"100%\" \/>\n<p style=\"text-align: justify;\">\n<h4 style=\"text-align: justify;\"><b>2. \u0397 \u03a43 \u03b5\u03bd\u03ad\u03c7\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03c1\u03cd\u03b8\u03bc\u03b9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03cc\u03c1\u03b5\u03be\u03b7\u03c2<\/b><\/h4>\n<p style=\"text-align: justify;\">\u0395\u03af\u03bd\u03b1\u03b9 \u03b3\u03bd\u03c9\u03c3\u03c4\u03cc \u03cc\u03c4\u03b9 \u03bf \u03c5\u03c0\u03b5\u03c1\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03c3\u03bc\u03cc\u03c2 \u03c3\u03c5\u03bd\u03bf\u03b4\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03cc\u03c1\u03b5\u03be\u03b7 \u03cc\u03bc\u03c9\u03c2 \u03b7 \u03c4\u03b1\u03c5\u03c4\u03cc\u03c7\u03c1\u03bf\u03bd\u03b7 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03ba\u03b1\u03c4\u03b1\u03bd\u03ac\u03bb\u03c9\u03c3\u03b7\u03c2 \u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b1\u03c2 \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c4\u03b5\u03bb\u03b9\u03ba\u03ac \u03c3\u03c4\u03b9\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c3\u03b5 \u03b1\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1 \u03b2\u03ac\u03c1\u03bf\u03c5\u03c2. \u039f\u03b9 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03af \u03bc\u03b5 \u03c4\u03bf\u03c5\u03c2 \u03bf\u03c0\u03bf\u03af\u03bf\u03c5\u03c2 \u03b7 \u03a43 \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03b5 \u03c5\u03c0\u03b5\u03c1\u03c6\u03b1\u03b3\u03af\u03b1 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b3\u03bd\u03c9\u03c3\u03c4\u03bf\u03af. \u03a3\u03b5 \u03bc\u03b9\u03b1 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03c3\u03b5 \u03b1\u03c1\u03bf\u03c5\u03c1\u03b1\u03af\u03bf\u03c5\u03c2 \u03c6\u03ac\u03bd\u03b7\u03ba\u03b5 \u03cc\u03c4\u03b9 \u03b7 \u03a43 \u03b1\u03bd\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03b7\u03c2 AMPK (AMP-activated protein kinase) \u03c3\u03c4\u03bf \u03bc\u03b5\u03c3\u03bf\u03ba\u03bf\u03b9\u03bb\u03b9\u03b1\u03ba\u03cc \u03c0\u03c5\u03c1\u03ae\u03bd\u03b1 \u03c4\u03bf\u03c5 \u03c5\u03c0\u03bf\u03b8\u03b1\u03bb\u03ac\u03bc\u03bf\u03c5 (VMH) \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03c4\u03bf\u03c0\u03b9\u03ba\u03ae \u03bb\u03b9\u03c0\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7 \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c3\u03c5\u03c3\u03c7\u03b5\u03c4\u03af\u03c3\u03b8\u03b7\u03ba\u03b5 \u03bc\u03b5 \u03b1\u03bb\u03bb\u03b1\u03b3\u03ad\u03c2 \u03c4\u03c9\u03bd \u03bf\u03c1\u03b5\u03be\u03b9\u03bf\u03b3\u03cc\u03bd\u03c9\u03bd \u03ba\u03b1\u03b9 \u03b1\u03bd\u03bf\u03c1\u03b5\u03be\u03b9\u03bf\u03b3\u03cc\u03bd\u03c9\u03bd \u03c0\u03b5\u03c0\u03c4\u03b9\u03b4\u03af\u03c9\u03bd \u03c4\u03bf\u03c5 \u03c4\u03bf\u03be\u03bf\u03b5\u03b9\u03b4\u03bf\u03cd\u03c2 \u03c0\u03c5\u03c1\u03ae\u03bd\u03b1 (5). \u0397 AMPK (AMP-activated protein kinase) \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2 \u03ad\u03bd\u03b4\u03b5\u03b9\u03b1\u03c2 \u0391\u03a4\u03a1 \u03bc\u03b5 \u03c3\u03c4\u03cc\u03c7\u03bf \u03c4\u03b7\u03bd \u03b5\u03be\u03bf\u03b9\u03ba\u03bf\u03bd\u03cc\u03bc\u03b7\u03c3\u03b7 \u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b1\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03bf\u03c1\u03b3\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc. \u03a3\u03c4\u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03b1\u03c5\u03c4\u03ae, \u03c0\u03b1\u03c1\u03cc\u03bb\u03bf \u03c0\u03bf\u03c5 \u03b4\u03b5\u03bd \u03b1\u03c0\u03bf\u03b4\u03b5\u03af\u03c7\u03b8\u03b7\u03ba\u03b5 \u03b1\u03b9\u03c4\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03c3\u03c5\u03c3\u03c7\u03ad\u03c4\u03b9\u03c3\u03b7 \u03bf\u03b9 \u03c3\u03c5\u03b3\u03b3\u03c1\u03b1\u03c6\u03b5\u03af\u03c2 \u03c5\u03c0\u03bf\u03c3\u03c4\u03b7\u03c1\u03af\u03b6\u03bf\u03c5\u03bd \u03cc\u03c4\u03b9 \u03c0\u03b9\u03b8\u03b1\u03bd\u03ac \u03b7 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03ae \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03b4\u03b9\u03b1\u03c6\u03cc\u03c1\u03c9\u03bd \u03bb\u03b9\u03c0\u03b9\u03b4\u03af\u03c9\u03bd \u03c3\u03c4\u03bf \u03bc\u03b5\u03c3\u03bf\u03ba\u03bf\u03b9\u03bb\u03b9\u03b1\u03ba\u03cc \u03c0\u03c5\u03c1\u03ae\u03bd\u03b1 \u03c0\u03bf\u03c5 \u03c5\u03c0\u03bf\u03b8\u03b1\u03bb\u03ac\u03bc\u03bf\u03c5, \u03b5\u03bd\u03ad\u03c7\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03c1\u03cd\u03b8\u03bc\u03b9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03cc\u03c1\u03b5\u03be\u03b7\u03c2 (5). \u0391\u03bd\u03c4\u03af\u03b8\u03b5\u03c4\u03b1 \u03cc\u03bc\u03c9\u03c2, \u03ac\u03bb\u03bb\u03bf\u03b9 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03ad\u03c2 \u03b2\u03c1\u03ae\u03ba\u03b1\u03bd \u03cc\u03c4\u03b9 \u03c3\u03c4\u03bf\u03bd \u03c5\u03c0\u03b5\u03c1\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03c3\u03bc\u03cc \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03b7 \u0391\u039c\u03a1\u039a \u03c3\u03c4\u03bf\u03bd \u03c5\u03c0\u03bf\u03b8\u03ac\u03bb\u03b1\u03bc\u03bf \u03ba\u03b1\u03b9 \u03b1\u03c5\u03c4\u03cc \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03b5 \u03c5\u03c0\u03b5\u03c1\u03c6\u03b1\u03b3\u03af\u03b1 \u03ba\u03b1\u03b9 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03bf\u03c1\u03b5\u03be\u03b9\u03bf\u03b3\u03cc\u03bd\u03c9\u03bd \u03ba\u03b1\u03b9 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b1\u03bd\u03bf\u03c1\u03b5\u03be\u03b9\u03bf\u03b3\u03cc\u03bd\u03c9\u03bd \u03c0\u03b5\u03c0\u03c4\u03b9\u03b4\u03af\u03c9\u03bd \u03c4\u03bf\u03c5 \u03c5\u03c0\u03bf\u03b8\u03b1\u03bb\u03ac\u03bc\u03bf\u03c5 (8). O \u03bc\u03b5\u03c3\u03bf\u03ba\u03bf\u03b9\u03bb\u03b9\u03b1\u03ba\u03cc\u03c2 \u03c0\u03c5\u03c1\u03ae\u03bd\u03b1\u03c2 \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03c0\u03b1\u03af\u03b6\u03b5\u03b9 \u03ba\u03b1\u03b8\u03bf\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03cc \u03c1\u03cc\u03bb\u03bf \u03c3\u03c4\u03b7\u03bd \u03c5\u03c0\u03b5\u03c1\u03c6\u03b1\u03b3\u03af\u03b1 \u03b1\u03c0\u03cc \u03a43 (9).<\/p>\n<h4 style=\"text-align: justify;\"><b>3. \u0397 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae \u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03b5 \u03c0\u03b1\u03c7\u03c5\u03c3\u03b1\u03c1\u03ba\u03af\u03b1; <\/b><\/h4>\n<p style=\"text-align: justify;\">\u038c\u03c0\u03c9\u03c2 \u03ae\u03b4\u03b7 \u03b1\u03bd\u03b1\u03c6\u03ad\u03c1\u03b8\u03b7\u03ba\u03b5 \u03b7 \u03a43 \u03b5\u03c0\u03ac\u03b3\u03b5\u03b9 \u03c4\u03cc\u03c3\u03bf \u03c4\u03b7\u03bd \u03c5\u03c0\u03bf\u03c7\u03c1\u03b5\u03c9\u03c4\u03b9\u03ba\u03ae \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03c3\u03b1\u03c1\u03bc\u03bf\u03c3\u03c4\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03bc\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7 \u03cc\u03bc\u03c9\u03c2 \u03ad\u03c7\u03b5\u03b9 \u03ba\u03b1\u03b9 \u03bf\u03c1\u03b5\u03be\u03b9\u03bf\u03b3\u03cc\u03bd\u03bf \u03b4\u03c1\u03ac\u03c3\u03b7, \u03bf\u03c0\u03cc\u03c4\u03b5 \u03c4\u03bf \u03c4\u03b5\u03bb\u03b9\u03ba\u03cc \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c3\u03c4\u03bf\u03bd \u03c5\u03c0\u03bf\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03c3\u03bc\u03cc \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03c1\u03bf\u03b4\u03b5\u03b4\u03b9\u03ba\u03b1\u03c3\u03bc\u03ad\u03bd\u03bf. \u03a0\u03c1\u03ac\u03b3\u03bc\u03b1\u03c4\u03b9, \u03b7 \u03bc\u03ad\u03c4\u03c1\u03b9\u03b1 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b2\u03ac\u03c1\u03bf\u03c5\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03c3\u03bf\u03b2\u03b1\u03c1\u03cc \u03c5\u03c0\u03bf\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03c3\u03bc\u03cc \u03bf\u03c6\u03b5\u03af\u03bb\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03ba\u03b1\u03c4\u03b1\u03ba\u03c1\u03ac\u03c4\u03b7\u03c3\u03b7 \u03cd\u03b4\u03b1\u03c4\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03cc\u03c7\u03b9 \u03c3\u03b5 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03bb\u03af\u03c0\u03bf\u03c5\u03c2 (10). \u0395\u03af\u03bd\u03b1\u03b9 \u03b3\u03bd\u03c9\u03c3\u03c4\u03cc \u03cc\u03c4\u03b9 \u03bf \u03c5\u03c0\u03bf\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03c3\u03bc\u03cc\u03c2 \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03ba\u03ac\u03b8\u03b1\u03c1\u03c3\u03b7 \u03b5\u03bb\u03b5\u03c5\u03b8\u03ad\u03c1\u03bf\u03c5 \u03cd\u03b4\u03b1\u03c4\u03bf\u03c2, \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af \u03b1\u03c0\u03c1\u03cc\u03c3\u03c6\u03bf\u03c1\u03b7 \u03ad\u03ba\u03ba\u03c1\u03b9\u03c3\u03b7 \u03b1\u03bd\u03c4\u03b9\u03b4\u03b9\u03bf\u03c5\u03c1\u03b7\u03c4\u03b9\u03ba\u03ae\u03c2 \u03bf\u03c1\u03bc\u03cc\u03bd\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03b9\u03c2 \u03c5\u03b4\u03c1\u03cc\u03c6\u03b9\u03bb\u03b5\u03c2 \u03b3\u03bb\u03c5\u03ba\u03bf\u03c3\u03b1\u03bc\u03b9\u03bd\u03bf\u03b3\u03bb\u03c5\u03ba\u03ac\u03bd\u03b5\u03c2 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b4\u03b9\u03ac\u03c6\u03bf\u03c1\u03bf\u03c5\u03c2 \u03b9\u03c3\u03c4\u03bf\u03cd\u03c2, \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03ce\u03bd\u03c4\u03b1\u03c2 \u03ad\u03c4\u03c3\u03b9 \u03ba\u03b1\u03c4\u03b1\u03ba\u03c1\u03ac\u03c4\u03b7\u03c3\u03b7 \u03cd\u03b4\u03b1\u03c4\u03bf\u03c2. \u03a3\u03b5 \u03bc\u03b9\u03b1 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7, \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03b8\u03b7\u03ba\u03b5 \u03c4\u03bf \u03b2\u03ac\u03c1\u03bf\u03c2 \u03c3\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2, \u03b7 \u03c3\u03cd\u03c3\u03c4\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c3\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2, \u03bf \u03b2\u03b1\u03c3\u03b9\u03ba\u03cc\u03c2 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03ba\u03cc\u03c2 \u03c1\u03c5\u03b8\u03bc\u03cc\u03c2 \u03ba\u03b1\u03b9 \u03b7 \u03c6\u03c5\u03c3\u03b9\u03ba\u03ae \u03b4\u03c1\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c3\u03b5 9 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03c3\u03bf\u03b2\u03b1\u03c1\u03cc \u03c5\u03c0\u03bf\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03c3\u03bc\u03cc (\u03bc\u03ad\u03c3\u03b7 \u03c4\u03b9\u03bc\u03ae TSH 102 mU\/L) \u03c0\u03c1\u03b9\u03bd \u03ba\u03b1\u03b9 \u03bc\u03b5\u03c4\u03ac 1 \u03c7\u03c1\u03cc\u03bd\u03bf \u03b5\u03c0\u03b9\u03c4\u03c5\u03c7\u03bf\u03cd\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03c5\u03c0\u03bf\u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7\u03c2 \u03bc\u03b5 \u03bb\u03b5\u03b2\u03bf\u03b8\u03c5\u03c1\u03bf\u03be\u03af\u03bd\u03b7 (10). \u0392\u03c1\u03ad\u03b8\u03b7\u03ba\u03b5 \u03cc\u03c4\u03b9 \u03c3\u03c4\u03bf\u03bd \u03c7\u03c1\u03cc\u03bd\u03bf \u03c4\u03bf \u03b2\u03ac\u03c1\u03bf\u03c2 \u03c3\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 \u03bc\u03b5\u03b9\u03ce\u03b8\u03b7\u03ba\u03b5 \u03c0\u03b5\u03c1\u03af \u03c4\u03b1 4 kg, \u03cc\u03c7\u03b9 \u03bb\u03cc\u03b3\u03c9 \u03c4\u03b7\u03c2 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03bb\u03af\u03c0\u03bf\u03c5\u03c2 \u03b1\u03bb\u03bb\u03ac \u03bb\u03cc\u03b3\u03c9 \u03c4\u03b7\u03c2 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03ac\u03bb\u03b9\u03c0\u03b7\u03c2 \u03bc\u03ac\u03b6\u03b1\u03c2. \u03a3\u03c4\u03b7\u03bd \u03af\u03b4\u03b9\u03b1 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7, \u03b1\u03c5\u03be\u03ae\u03b8\u03b7\u03ba\u03b5 \u03bf \u03b2\u03b1\u03c3\u03b9\u03ba\u03cc\u03c2 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03ba\u03cc\u03c2 \u03c1\u03c5\u03b8\u03bc\u03cc\u03c2 \u03ba\u03b1\u03c4\u03ac 215 kcal\/24h \u03c4\u03bf \u03bf\u03c0\u03bf\u03af\u03bf \u03b8\u03b1 \u03b1\u03bd\u03c4\u03b9\u03c3\u03c4\u03bf\u03b9\u03c7\u03bf\u03cd\u03c3\u03b5 \u03c3\u03b5 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03bb\u03af\u03c0\u03bf\u03c5\u03c2 \u03ba\u03b1\u03c4\u03ac 4,4 kg \u03c3\u03b5 \u03ad\u03bd\u03b1 \u03b5\u03be\u03ac\u03bc\u03b7\u03bd\u03bf \u03ba\u03b1\u03b9 \u03b1\u03c6\u03b5\u03c4\u03ad\u03c1\u03bf\u03c5 \u03b1\u03c5\u03be\u03ae\u03b8\u03b7\u03ba\u03b5 \u03ba\u03b1\u03b9 \u03b7 \u03c6\u03c5\u03c3\u03b9\u03ba\u03ae \u03b4\u03c1\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1. \u039f\u03b9 \u03c3\u03c5\u03b3\u03b3\u03c1\u03b1\u03c6\u03b5\u03af\u03c2 \u03b4\u03b9\u03ba\u03b1\u03b9\u03bf\u03bb\u03bf\u03b3\u03bf\u03cd\u03bd \u03c4\u03bf \u03c0\u03b1\u03c1\u03ac\u03b4\u03bf\u03be\u03bf \u03b1\u03c5\u03c4\u03cc \u03b5\u03cd\u03c1\u03b7\u03bc\u03b1, \u03bb\u03ad\u03b3\u03bf\u03bd\u03c4\u03b1\u03c2 \u03cc\u03c4\u03b9 \u03c4\u03b1\u03c5\u03c4\u03cc\u03c7\u03c1\u03bf\u03bd\u03b1 \u03c0\u03b9\u03b8\u03b1\u03bd\u03ac \u03b1\u03c5\u03be\u03ae\u03b8\u03b7\u03ba\u03b5 \u03b7 \u03b7\u03bc\u03b5\u03c1\u03ae\u03c3\u03b9\u03b1 \u03c0\u03c1\u03cc\u03c3\u03bb\u03b7\u03c8\u03b7 \u03b8\u03b5\u03c1\u03bc\u03af\u03b4\u03c9\u03bd \u03b1\u03bd \u03ba\u03b1\u03b9 \u03b4\u03b5\u03bd \u03c4\u03b7\u03bd \u03ba\u03b1\u03c4\u03ad\u03b3\u03c1\u03b1\u03c8\u03b1\u03bd, \u03bb\u03cc\u03b3\u03c9 \u03c4\u03b7\u03c2 \u03b3\u03bd\u03c9\u03c3\u03c4\u03ae\u03c2 \u03bf\u03c1\u03b5\u03be\u03b9\u03bf\u03b3\u03cc\u03bd\u03bf\u03c5 \u03b4\u03c1\u03ac\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03a43. \u0399\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c0\u03bf\u03bb\u03c5\u03c3\u03c5\u03b6\u03b7\u03c4\u03b7\u03bc\u03ad\u03bd\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03c3\u03c7\u03ad\u03c3\u03b7 \u03c5\u03c0\u03bf\u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03bf\u03cd \u03c5\u03c0\u03bf\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03c3\u03bc\u03bf\u03cd \u03ae \u03ba\u03b1\u03b9 \u03bc\u03cc\u03bd\u03bf \u03c4\u03b7\u03c2 \u03bc\u03ad\u03c4\u03c1\u03b9\u03b1\u03c2 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 TSH \u03b1\u03bb\u03bb\u03ac \u03b5\u03bd\u03c4\u03cc\u03c2 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ce\u03bd \u03bf\u03c1\u03af\u03c9\u03bd \u03c3\u03b5 \u03c0\u03b1\u03c7\u03cd\u03c3\u03b1\u03c1\u03ba\u03b1 \u03ac\u03c4\u03bf\u03bc\u03b1, \u03c4\u03b1 \u03bf\u03c0\u03bf\u03af\u03b1 \u03bc\u03b1\u03ba\u03c1\u03bf\u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03b8\u03b1 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03c3\u03b1\u03bd \u03bd\u03b1 \u03bf\u03b4\u03b7\u03b3\u03ae\u03c3\u03bf\u03c5\u03bd \u03c3\u03b5 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b2\u03ac\u03c1\u03bf\u03c5\u03c2 \u03c3\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2, \u03bb\u03cc\u03b3\u03c9 \u03c4\u03b7\u03c2 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03b2\u03b1\u03c3\u03b9\u03ba\u03bf\u03cd \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03ba\u03bf\u03cd \u03c1\u03c5\u03b8\u03bc\u03bf\u03cd. \u03a3\u03b5 9 \u03c5\u03c0\u03bf\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c3\u03b5 \u03c5\u03c0\u03bf\u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7 \u03bc\u03b5 \u03b8\u03c5\u03c1\u03bf\u03be\u03af\u03bd\u03b7 \u03b1\u03bb\u03bb\u03b1\u03b3\u03ad\u03c2 \u03c3\u03c4\u03b7 \u03b4\u03cc\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b8\u03c5\u03c1\u03bf\u03be\u03af\u03bd\u03b7\u03c2 \u03ad\u03c4\u03c3\u03b9 \u03ce\u03c3\u03c4\u03b5 \u03bd\u03b1 \u03bc\u03b5\u03c4\u03b1\u03b2\u03ac\u03bb\u03bb\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03b7\u03c2 TSH \u03c3\u03c5\u03bd\u03bf\u03b4\u03b5\u03cd\u03c4\u03b7\u03ba\u03b1\u03bd \u03b1\u03c0\u03cc \u03b1\u03bb\u03bb\u03b1\u03b3\u03ad\u03c2 \u03c3\u03c4\u03bf \u03b2\u03b1\u03c3\u03b9\u03ba\u03cc \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03ba\u03cc \u03c1\u03c5\u03b8\u03bc\u03cc. \u03a3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b1 \u03b7 \u03bc\u03b5\u03c4\u03b1\u03ba\u03af\u03bd\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b5\u03c0\u03b9\u03c0\u03ad\u03b4\u03c9\u03bd \u03c4\u03b7\u03c2 TSH \u03b1\u03c0\u03cc 0,1 \u03ad\u03c9\u03c2 10 \u03bc\u03b5\u03af\u03c9\u03c3\u03b5 \u03c4\u03bf \u03b2\u03b1\u03c3\u03b9\u03ba\u03cc \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03ba\u03cc \u03c1\u03c5\u03b8\u03bc\u03cc \u03ba\u03b1\u03c4\u03ac 17% (11,12). \u03a3\u03b5 \u03bc\u03b9\u03b1 \u0394\u03b1\u03bd\u03ad\u03b6\u03b9\u03ba\u03b7 cross-sectional \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03c0\u03b5\u03c1\u03af \u03c4\u03b9\u03c2 4000 \u03b5\u03c5\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ad\u03c2 \u03b3\u03c5\u03bd\u03b1\u03af\u03ba\u03b5\u03c2 \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03b9\u03bf\u03c0\u03bf\u03b9\u03ae\u03b8\u03b7\u03ba\u03b1\u03bd \u03bc\u03b5 \u03b2\u03ac\u03c3\u03b7 \u03c4\u03b7\u03bd \u03c4\u03b9\u03bc\u03ae \u03c4\u03b7\u03c2 TSH (\u03c4\u03b9\u03bc\u03ad\u03c2 \u03b1\u03c0\u03cc 0,4-3,6 mU\/L) \u03ba\u03b1\u03b9 \u03b2\u03c1\u03ad\u03b8\u03b7\u03ba\u03b5 \u03cc\u03c4\u03b9 \u03cc\u03c3\u03bf \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03c4\u03b9\u03bc\u03ae \u03c4\u03b7\u03c2 TSH \u03c4\u03cc\u03c3\u03bf \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b1\u03c4\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03ba\u03b1\u03b9 \u03bf \u0394\u03b5\u03af\u03ba\u03c4\u03b7\u03c2 \u039c\u03ac\u03b6\u03b1\u03c2 \u03a3\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 (13). \u03a3\u03c4\u03b7\u03bd \u03af\u03b4\u03b9\u03b1 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03bf\u03b9 \u03b3\u03c5\u03bd\u03b1\u03af\u03ba\u03b5\u03c2 \u03bc\u03b5 \u03c4\u03b9\u03bc\u03ad\u03c2 TSH \u03b1\u03c0\u03cc 1-1,99 mU\/L \u03c3\u03b5 \u03c3\u03c7\u03ad\u03c3\u03b7 \u03bc\u03b5 \u03b1\u03c5\u03c4\u03ad\u03c2 \u03bc\u03b5 TSH &gt; 3,6 mU\/L \u03ba\u03b1\u03b9 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae FT4 \u03ae\u03c4\u03b1\u03bd \u03b5\u03bb\u03b1\u03c6\u03c1\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03ba\u03b1\u03c4\u03ac 4 kg \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5. \u038c\u03bc\u03c9\u03c2 \u03c3\u03b5 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03bc\u03b5 \u03c5\u03c0\u03bf\u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03c5\u03c0\u03bf\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03c3\u03bc\u03cc \u03c3\u03c4\u03bf\u03c5\u03c2 \u03bf\u03c0\u03bf\u03af\u03bf\u03c5\u03c2 \u03c7\u03bf\u03c1\u03b7\u03b3\u03ae\u03b8\u03b7\u03ba\u03b5 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 \u03b8\u03c5\u03c1\u03bf\u03be\u03af\u03bd\u03b7 \u03ba\u03b1\u03b9 \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03b8\u03b7\u03ba\u03b5 \u03c4\u03bf \u03b2\u03ac\u03c1\u03bf\u03c2 \u03c3\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03c0\u03c1\u03b9\u03bd \u03ba\u03b1\u03b9 \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03b4\u03b5\u03bd \u03c3\u03b7\u03bc\u03b5\u03b9\u03ce\u03b8\u03b7\u03ba\u03b5 \u03ba\u03b1\u03bc\u03af\u03b1 \u03b1\u03be\u03b9\u03cc\u03bb\u03bf\u03b3\u03b7 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ae (14,15).<\/p>\n<h4 style=\"text-align: justify;\"><b>4. \u0397 \u03c0\u03b1\u03c7\u03c5\u03c3\u03b1\u03c1\u03ba\u03af\u03b1 \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03b5 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae \u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1;<\/b><\/h4>\n<p style=\"text-align: justify;\">\u03a0\u03c1\u03bf \u03b5\u03c4\u03ce\u03bd \u03b5\u03af\u03c7\u03b5 \u03b4\u03b9\u03b1\u03c0\u03b9\u03c3\u03c4\u03c9\u03b8\u03b5\u03af \u03cc\u03c4\u03b9 \u03b7 \u03c5\u03c0\u03b5\u03c1\u03c6\u03b1\u03b3\u03af\u03b1 \u03ba\u03b1\u03b9 \u03b7 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b2\u03ac\u03c1\u03bf\u03c5\u03c2 \u03c3\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c3\u03b5 \u03b1\u03bd\u03c4\u03af\u03b8\u03b5\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b7 \u03bd\u03b7\u03c3\u03c4\u03b5\u03af\u03b1 \u03bf\u03b4\u03b7\u03b3\u03bf\u03cd\u03bd \u03c3\u03b5 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03a43 \u03b5\u03bd\u03ce \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03b7\u03c2 \u03a44 \u03ba\u03b1\u03b9 TSH \u03b4\u03b5\u03bd \u03bc\u03b5\u03c4\u03b1\u03b2\u03ac\u03bb\u03bb\u03bf\u03bd\u03c4\u03b1\u03b9 (16). \u03a3\u03c4\u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03b1\u03c5\u03c4\u03ae \u03b8\u03b5\u03c9\u03c1\u03ae\u03b8\u03b7\u03ba\u03b5 \u03cc\u03c4\u03b9 \u03b7 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03a43 \u03bf\u03c6\u03b5\u03af\u03bb\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03c0\u03b5\u03c1\u03b9\u03c6\u03b5\u03c1\u03b9\u03ba\u03ae \u03bc\u03b5\u03c4\u03b1\u03c4\u03c1\u03bf\u03c0\u03ae \u03c4\u03b7\u03c2 \u03a44 \u03ba\u03b1\u03b9 \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03cd\u03c4\u03b7\u03ba\u03b5 \u03c9\u03c2 \u03c0\u03c1\u03bf\u03c3\u03b1\u03c1\u03bc\u03bf\u03c3\u03c4\u03b9\u03ba\u03cc\u03c2 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2 \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7\u03c2 \u03c0\u03b1\u03c7\u03c5\u03c3\u03b1\u03c1\u03ba\u03af\u03b1\u03c2. \u03a4\u03c1\u03b9\u03ac\u03bd\u03c4\u03b1 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03b1\u03c1\u03b3\u03cc\u03c4\u03b5\u03c1\u03b1 \u03b4\u03b9\u03b1\u03c0\u03b9\u03c3\u03c4\u03ce\u03b8\u03b7\u03ba\u03b5 \u03cc\u03c4\u03b9 \u03c4\u03b1 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03bc\u03b5 \u03c3\u03bf\u03b2\u03b1\u03c1\u03ae \u03c0\u03b1\u03c7\u03c5\u03c3\u03b1\u03c1\u03ba\u03af\u03b1 \u03ba\u03b1\u03b9 \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03ac \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7\u03c2 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae\u03c2 \u03c5\u03c0\u03b5\u03c1\u03bf\u03be\u03b5\u03b9\u03b4\u03ac\u03c3\u03b7\u03c2 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03b2\u03b1\u03c3\u03b9\u03ba\u03ad\u03c2 \u03c4\u03b9\u03bc\u03ad\u03c2 TSH \u03c3\u03b5 \u03c3\u03c7\u03ad\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b1 \u03bd\u03bf\u03c1\u03bc\u03bf\u03b2\u03b1\u03c1\u03ae \u03ac\u03c4\u03bf\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03a43 \u03ba\u03b1\u03b9 \u03a44 (17). \u03a0\u03b9\u03b8\u03b1\u03bd\u03ac \u03c3\u03b5 \u03b1\u03c5\u03c4\u03ae \u03c4\u03b7\u03bd \u03c0\u03c1\u03ce\u03c4\u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03b4\u03b5\u03bd \u03b2\u03c1\u03ad\u03b8\u03b7\u03ba\u03b1\u03bd \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03ad\u03c2 \u03c3\u03c4\u03b7\u03bd \u03a4SH \u03bb\u03cc\u03b3\u03c9 \u03c4\u03b7\u03c2 \u03c7\u03c1\u03ae\u03c3\u03b7\u03c2 \u03c4\u03cc\u03c4\u03b5 \u03bc\u03b7 \u03b5\u03c5\u03b1\u03af\u03c3\u03b8\u03b7\u03c4\u03c9\u03bd \u03bc\u03b5\u03b8\u03cc\u03b4\u03c9\u03bd \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03bc\u03ad\u03c4\u03c1\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2. \u03a3\u03c4\u03b7 \u03c3\u03c5\u03bd\u03ad\u03c7\u03b5\u03b9\u03b1, \u03c3\u03b5\u03b9\u03c1\u03ac \u03bc\u03b5\u03bb\u03b5\u03c4\u03ce\u03bd \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03af\u03c9\u03c3\u03b5 \u03c4\u03b1 \u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03b7\u03c2 TSH \u03c3\u03b5 \u03c0\u03b1\u03c7\u03cd\u03c3\u03b1\u03c1\u03ba\u03bf\u03c5\u03c2 \u03c3\u03b5 \u03c3\u03c7\u03ad\u03c3\u03b7 \u03bc\u03b5 \u03bd\u03bf\u03c1\u03bc\u03bf\u03b2\u03b1\u03c1\u03ae \u03ac\u03c4\u03bf\u03bc\u03b1 (13,17-20) \u03b5\u03bd\u03ce \u03b4\u03b5\u03bd \u03c5\u03c0\u03ae\u03c1\u03be\u03b5 \u03bf\u03bc\u03bf\u03c6\u03c9\u03bd\u03af\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03c9\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03bf\u03c1\u03bc\u03bf\u03bd\u03ce\u03bd, \u03c4\u03b1 \u03bf\u03c0\u03bf\u03af\u03b1 \u03ac\u03bb\u03bb\u03bf\u03c4\u03b5 \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03ac\u03c6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c9\u03c2 \u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b1 (16,17), \u03ae \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b1 (18,20,21) \u03ae \u03ba\u03b1\u03b9 \u03c7\u03c9\u03c1\u03af\u03c2 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03ad\u03c2 (22). \u03a3\u03c4\u03b7\u03bd \u03c0\u03b1\u03c7\u03c5\u03c3\u03b1\u03c1\u03ba\u03af\u03b1 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c4\u03cc\u03c3\u03bf \u03b7 \u03b2\u03b1\u03c3\u03b9\u03ba\u03ae \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03b7 \u03ba\u03b1\u03c4\u03ac \u03ce\u03c3\u03b5\u03b9\u03c2 \u03ad\u03ba\u03ba\u03c1\u03b9\u03c3\u03b7 \u03c4\u03b7\u03c2 TSH (22), \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b1\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1 \u03b2\u03ac\u03c1\u03bf\u03c5\u03c2 \u03b5\u03af\u03c4\u03b5 \u03b1\u03c5\u03c4\u03ae \u03c3\u03c5\u03bc\u03b2\u03b1\u03af\u03bd\u03b5\u03b9 \u03bc\u03b5\u03c4\u03ac \u03b2\u03b1\u03c1\u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03b5\u03c0\u03ad\u03bc\u03b2\u03b1\u03c3\u03b7 \u03ae \u03bc\u03b5 \u03b4\u03af\u03b1\u03b9\u03c4\u03b1 (20,23,24), \u03c5\u03c0\u03bf\u03b4\u03b7\u03bb\u03ce\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03cc\u03c4\u03b9 \u03b4\u03b5\u03bd \u03c0\u03c1\u03cc\u03ba\u03b5\u03b9\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c0\u03c1\u03c9\u03c4\u03bf\u03c0\u03b1\u03b8\u03ae \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ae \u03c4\u03b7\u03c2 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2 \u03b1\u03bb\u03bb\u03ac \u03bc\u03ac\u03bb\u03bb\u03bf\u03bd \u03b3\u03b9\u03b1 \u03c3\u03c5\u03bd\u03ad\u03c0\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2. \u0397 \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03b4\u03b5 \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c0\u03bd\u03af\u03c3\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c3\u03c4\u03b7 \u03c3\u03c7\u03ad\u03c3\u03b7 \u03c0\u03b1\u03c7\u03c5\u03c3\u03b1\u03c1\u03ba\u03af\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b7\u03c2 TSH \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03bc\u03c6\u03b9\u03c3\u03b2\u03b7\u03c4\u03ae\u03c3\u03b9\u03bc\u03b7 (19).<\/p>\n<p style=\"text-align: justify;\">\u03a3\u03c4\u03b7\u03bd \u03c0\u03b1\u03c7\u03c5\u03c3\u03b1\u03c1\u03ba\u03af\u03b1, \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bf \u03cc\u03b3\u03ba\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03bf\u03cd\u03c2 \u03b1\u03b4\u03ad\u03bd\u03b1 \u03ba\u03b1\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03bf\u03c2 \u03c4\u03cc\u03c3\u03bf \u03c4\u03bf\u03c5 \u03b2\u03ac\u03c1\u03bf\u03c5\u03c2 \u03c3\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 \u03b1\u03bb\u03bb\u03ac \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c4\u03b7\u03c2 \u03ac\u03bb\u03b9\u03c0\u03b7\u03c2 \u03bc\u03ac\u03b6\u03b1\u03c2 (20,25) \u03ba\u03b1\u03b9 \u03bf \u03bf\u03c0\u03bf\u03af\u03bf\u03c2 \u03c5\u03c0\u03bf\u03c3\u03c4\u03c1\u03ad\u03c6\u03b5\u03b9 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b1\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1 \u03b2\u03ac\u03c1\u03bf\u03c5\u03c2 (20). \u03a5\u03c0\u03b5\u03c1\u03b7\u03c7\u03bf\u03b3\u03c1\u03b1\u03c6\u03b9\u03ba\u03ac \u03bf \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03ae\u03c2 \u03b1\u03b4\u03ad\u03bd\u03b1\u03c2 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c5\u03c0\u03bf\u03b7\u03c7\u03bf\u03b3\u03b5\u03bd\u03ae\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03c3\u03bf\u03bc\u03bf\u03b9\u03ac\u03b6\u03b5\u03b9 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03c5\u03c0\u03b5\u03c1\u03b7\u03c7\u03bf\u03b3\u03c1\u03b1\u03c6\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03c4\u03b7\u03c2 \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03b7\u03c2 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03af\u03c4\u03b9\u03b4\u03bf\u03c2 \u03c7\u03c9\u03c1\u03af\u03c2 \u03cc\u03bc\u03c9\u03c2 \u03bd\u03b1 \u03c4\u03b5\u03ba\u03bc\u03b7\u03c1\u03b9\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03bf\u03c3\u03af\u03b1 (26-28). \u03a3\u03b5 \u03bc\u03b9\u03b1 \u03b1\u03c0\u03cc \u03b1\u03c5\u03c4\u03ad\u03c2 \u03c4\u03b9\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03b8\u03b7\u03ba\u03b5 \u03bb\u03b5\u03c0\u03c4\u03bf\u03bc\u03b5\u03c1\u03ce\u03c2 \u03b7 \u03c3\u03c5\u03c3\u03c7\u03ad\u03c4\u03b9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c5\u03c0\u03bf\u03b7\u03c7\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1\u03c2 \u03c3\u03c4\u03bf \u03c5\u03c0\u03b5\u03c1\u03b7\u03c7\u03bf\u03b3\u03c1\u03ac\u03c6\u03b7\u03bc\u03b1 \u03c4\u03bf\u03c5 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03bf\u03cd\u03c2 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03cd\u03c0\u03b1\u03c1\u03be\u03b7 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c4\u03b5\u03ba\u03bc\u03b7\u03c1\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7\u03c2 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03c3\u03bf\u03b2\u03b1\u03c1\u03ae \u03c0\u03b1\u03c7\u03c5\u03c3\u03b1\u03c1\u03ba\u03af\u03b1 (26). \u0394\u03b9\u03b1\u03c0\u03b9\u03c3\u03c4\u03ce\u03b8\u03b7\u03ba\u03b5 \u03cc\u03c4\u03b9 \u03bc\u03cc\u03bd\u03bf \u03c4\u03bf 20% \u03c4\u03c9\u03bd \u03c0\u03b1\u03c7\u03c5\u03c3\u03ac\u03c1\u03ba\u03c9\u03bd \u03bc\u03b5 \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03c5\u03c0\u03bf\u03b7\u03c7\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1\u03c2 \u03c3\u03c4\u03bf\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03ae \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 86% \u03c4\u03c9\u03bd \u03bd\u03bf\u03c1\u03bc\u03bf\u03b2\u03b1\u03c1\u03ce\u03bd \u03bc\u03b1\u03c1\u03c4\u03cd\u03c1\u03c9\u03bd \u03bc\u03b5 \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03bf\u03b9\u03c7\u03b7 \u03c5\u03c0\u03b5\u03c1\u03b7\u03c7\u03bf\u03b3\u03c1\u03b1\u03c6\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03b5\u03af\u03c7\u03b1\u03bd \u03b8\u03b5\u03c4\u03b9\u03ba\u03ac \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1. \u0391\u03c0\u03cc \u03c4\u03bf\u03c5\u03c2 \u03c0\u03b1\u03c7\u03cd\u03c3\u03b1\u03c1\u03ba\u03bf\u03c5\u03c2 \u03bc\u03b5 \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03ac \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03c4\u03bf 12% \u03b5\u03af\u03c7\u03b5 \u03bc\u03b5\u03bc\u03bf\u03bd\u03c9\u03bc\u03ad\u03bd\u03b1 \u03c5\u03c8\u03b7\u03bb\u03ae TSH \u03b5\u03bd\u03ce \u03c3\u03c4\u03bf\u03c5\u03c2 \u03c5\u03c0\u03bf\u03bb\u03bf\u03af\u03c0\u03bf\u03c5\u03c2 \u03b4\u03b5\u03bd \u03c4\u03b5\u03ba\u03bc\u03b7\u03c1\u03b9\u03ce\u03b8\u03b7\u03ba\u03b5 \u03ba\u03b1\u03bc\u03b9\u03ac \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae \u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1.<\/p>\n<p style=\"text-align: justify;\">\u039b\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c5\u03c0\u03cc\u03c8\u03b7 \u03cc\u03bb\u03b1 \u03c4\u03b1 \u03c0\u03c1\u03bf\u03b7\u03b3\u03bf\u03cd\u03bc\u03b5\u03bd\u03b1 \u03c0\u03b9\u03b8\u03b1\u03bd\u03ac \u03bd\u03b1 \u03c5\u03c0\u03b5\u03c1\u03b4\u03b9\u03b1\u03b3\u03b9\u03b3\u03bd\u03ce\u03c3\u03ba\u03b5\u03c4\u03b1\u03b9 \u03bf \u03c5\u03c0\u03bf\u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc\u03c2 \u03c5\u03c0\u03bf\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03c3\u03bc\u03cc\u03c2 \u03c3\u03c4\u03b7\u03bd \u03c0\u03b1\u03c7\u03c5\u03c3\u03b1\u03c1\u03ba\u03af\u03b1 \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03bd\u03b1 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03b5\u03c0\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03c3\u03c4\u03b7\u03bd \u03c0\u03b1\u03c7\u03c5\u03c3\u03b1\u03c1\u03ba\u03af\u03b1 \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03c4\u03bf\u03c5 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03bf\u03cd \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03bf\u03cd (17,21). \u03a4\u03bf \u03b5\u03c1\u03ce\u03c4\u03b7\u03bc\u03b1 \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ba\u03cd\u03c0\u03c4\u03b5\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03ac\u03bd \u03c4\u03b9\u03bc\u03ad\u03c2 TSH \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b5\u03c2 \u03c4\u03bf\u03c5 4,2 mIU\/L \u03b1\u03c1\u03ba\u03bf\u03cd\u03bd \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03b8\u03ad\u03c3\u03bf\u03c5\u03bd \u03c4\u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c5\u03c0\u03bf\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03c3\u03bc\u03bf\u03cd \u03c3\u03c4\u03b7\u03bd \u03c0\u03b1\u03c7\u03c5\u03c3\u03b1\u03c1\u03ba\u03af\u03b1 \u03ae \u03bc\u03ae\u03c0\u03c9\u03c2 \u03b8\u03b1 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03c4\u03b5\u03b8\u03bf\u03cd\u03bd \u03ac\u03bb\u03bb\u03b1 \u03cc\u03c1\u03b9\u03b1 \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03c3\u03bf\u03b2\u03b1\u03c1\u03ae \u03c0\u03b1\u03c7\u03c5\u03c3\u03b1\u03c1\u03ba\u03af\u03b1. \u03a4\u03bf \u03b5\u03c1\u03ce\u03c4\u03b7\u03bc\u03b1 \u03b1\u03c5\u03c4\u03cc \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ac \u03c0\u03c1\u03cc\u03c3\u03c6\u03b1\u03c4\u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7, \u03c3\u03c4\u03b7\u03bd \u03bf\u03c0\u03bf\u03af\u03b1 \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03b8\u03b7\u03ba\u03b1\u03bd 350 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03bc\u03b5 \u03c3\u03bf\u03b2\u03b1\u03c1\u03ae \u03c0\u03b1\u03c7\u03c5\u03c3\u03b1\u03c1\u03ba\u03af\u03b1. \u03a3\u03c4\u03b7\u03bd \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03b1\u03c5\u03c4\u03ae \u03b2\u03c1\u03ad\u03b8\u03b7\u03ba\u03b5 \u03cc\u03c4\u03b9 \u03c4\u03b1 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03bc\u03b5 \u03c3\u03bf\u03b2\u03b1\u03c1\u03ae \u03c0\u03b1\u03c7\u03c5\u03c3\u03b1\u03c1\u03ba\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c5\u03c0\u03bf\u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03bf \u03c5\u03c0\u03bf\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03c3\u03bc\u03cc (\u03c3\u03cd\u03bc\u03c6\u03c9\u03bd\u03b1 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03ba\u03bb\u03b1\u03c3\u03b9\u03ba\u03cc \u03bf\u03c1\u03b9\u03c3\u03bc\u03cc, TSH &gt; 4 mIU\/L \u03ba\u03b1\u03b9 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03c4\u03b9\u03bc\u03ad\u03c2 F\u03a44) \u03b5\u03af\u03c7\u03b1\u03bd \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b7 \u03b5\u03c0\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03bf\u03bc\u03ac\u03b4\u03bf\u03c2 \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5 \u03bd\u03bf\u03c1\u03bc\u03bf\u03b2\u03b1\u03c1\u03ce\u03bd \u03b1\u03c4\u03cc\u03bc\u03c9\u03bd \u03bc\u03b5 \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03c2 \u03c4\u03b9\u03bc\u03ad\u03c2 TSH (32,1% vs 66.1%), \u03b4\u03b5\u03bd \u03c5\u03c0\u03b5\u03c1\u03af\u03c3\u03c7\u03c5\u03b1\u03bd \u03bf\u03b9 \u03b3\u03c5\u03bd\u03b1\u03af\u03ba\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03b4\u03b5\u03bd \u03c5\u03c0\u03ae\u03c1\u03c7\u03b5 \u03bc\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03bf\u03c2 \u03bb\u03cc\u03b3\u03bf\u03c2 FT4\/FT3 (18). \u0395\u03c0\u03bf\u03bc\u03ad\u03bd\u03c9\u03c2 \u03bf\u03b9 \u03b1\u03bb\u03bb\u03b1\u03b3\u03ad\u03c2 \u03c4\u03c9\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03c4\u03c1\u03c9\u03bd \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c0\u03b9\u03b8\u03b1\u03bd\u03ac \u03bd\u03b1 \u03bc\u03b7\u03bd \u03ad\u03c7\u03bf\u03c5\u03bd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03c4\u03b5\u03af\u03bd\u03bf\u03c5\u03bd \u03c4\u03bf \u03c3\u03c7\u03b5\u03b4\u03b9\u03b1\u03c3\u03bc\u03cc \u03bc\u03b5\u03bb\u03b5\u03c4\u03ce\u03bd \u03c3\u03c4\u03b9\u03c2 \u03bf\u03c0\u03bf\u03af\u03b5\u03c2 \u03b8\u03b1 \u03b5\u03be\u03b5\u03c4\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03b4\u03c1\u03ac\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03bf\u03c1\u03bc\u03bf\u03bd\u03ce\u03bd \u03c3\u03b5 \u03c0\u03b5\u03c1\u03b9\u03c6\u03b5\u03c1\u03b9\u03ba\u03bf\u03cd\u03c2 \u03b9\u03c3\u03c4\u03bf\u03cd\u03c2 \u03c3\u03c4\u03cc\u03c7\u03bf\u03c5\u03c2 \u03c0\u03c1\u03bf\u03ba\u03b5\u03b9\u03bc\u03ad\u03bd\u03bf\u03c5 \u03bd\u03b1 \u03b4\u03b9\u03b1\u03c0\u03b9\u03c3\u03c4\u03c9\u03b8\u03b5\u03af \u03b5\u03ac\u03bd \u03c0\u03c1\u03ac\u03b3\u03bc\u03b1\u03c4\u03b9 \u03bf\u03b9 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03ac\u03c3\u03c7\u03bf\u03c5\u03bd. \u03a3\u03b5 \u03ac\u03bb\u03bb\u03b7 \u03cc\u03bc\u03c9\u03c2 cross-sectional \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03c3\u03b5 \u03c0\u03b1\u03c7\u03cd\u03c3\u03b1\u03c1\u03ba\u03bf\u03c5\u03c2 \u03b5\u03ba \u03c4\u03c9\u03bd \u03bf\u03c0\u03bf\u03af\u03c9\u03bd \u03c4\u03bf 69% \u03b5\u03af\u03c7\u03b5 \u03c3\u03bf\u03b2\u03b1\u03c1\u03ae \u03c0\u03b1\u03c7\u03c5\u03c3\u03b1\u03c1\u03ba\u03af\u03b1 \u03b4\u03b9\u03b1\u03c0\u03b9\u03c3\u03c4\u03ce\u03b8\u03b7\u03ba\u03b1\u03bd \u03b8\u03b5\u03c4\u03b9\u03ba\u03ac \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03c3\u03c4\u03bf 23,6% \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 12,7% \u03c4\u03c9\u03bd \u03bd\u03bf\u03c1\u03bc\u03bf\u03b2\u03b1\u03c1\u03ce\u03bd \u03bc\u03b1\u03c1\u03c4\u03cd\u03c1\u03c9\u03bd \u03ba\u03b1\u03b9 \u03b2\u03c1\u03ad\u03b8\u03b7\u03ba\u03b5 \u03cc\u03c4\u03b9 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03bb\u03b5\u03c0\u03c4\u03af\u03bd\u03b7\u03c2 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03bf\u03cd\u03c3\u03b1\u03bd \u03b1\u03bd\u03b5\u03be\u03ac\u03c1\u03c4\u03b7\u03c4\u03bf \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u03c3\u03b5 \u03c3\u03c7\u03ad\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03bf \u03b2\u03ac\u03c1\u03bf\u03c2 \u03c3\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 \u03c4\u03bf\u03c5\u03c2. \u03a0\u03b1\u03c1\u03b1\u03b4\u03cc\u03be\u03c9\u03c2 \u03cc\u03bc\u03c9\u03c2 \u03c3\u03c4\u03b7\u03bd \u03af\u03b4\u03b9\u03b1 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03b5\u03bd\u03ce \u03ba\u03b1\u03c4\u03b5\u03b3\u03c1\u03ac\u03c6\u03b7\u03c3\u03b1\u03bd \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 FT3 \u03ba\u03b1\u03b9 FT4 \u03b4\u03b5\u03bd \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03ae\u03b8\u03b7\u03ba\u03b5 \u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b7 TSH \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03c4\u03cc\u03c3\u03bf \u03c4\u03c9\u03bd \u03bd\u03bf\u03c1\u03bc\u03bf\u03b2\u03b1\u03c1\u03ce\u03bd \u03bc\u03b1\u03c1\u03c4\u03cd\u03c1\u03c9\u03bd \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03c4\u03c9\u03bd \u03c0\u03b1\u03c7\u03cd\u03c3\u03b1\u03c1\u03ba\u03c9\u03bd \u03bc\u03b5 \u03b8\u03b5\u03c4\u03b9\u03ba\u03ac \u03ae \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03ac \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 (21). \u03a4\u03b1 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03cc\u03c1\u03b9\u03b1 \u03c4\u03b7\u03c2 TSH \u03c0\u03c1\u03bf\u03ba\u03cd\u03c0\u03c4\u03bf\u03c5\u03bd \u03b1\u03c0\u03cc \u03c4\u03bf mean \u00b1 2 SD \u03c4\u03c9\u03bd \u03c4\u03b9\u03bc\u03ce\u03bd \u03c4\u03b7\u03c2 \u03a4SH \u03c3\u03c4\u03bf\u03bd \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03cc \u03bc\u03b5 \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03ac \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae \u03bd\u03cc\u03c3\u03bf (29). \u03a4\u03bf \u03c0\u03c1\u03cc\u03b2\u03bb\u03b7\u03bc\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03b7 \u03ba\u03b1\u03c4\u03b1\u03bd\u03bf\u03bc\u03ae \u03c4\u03b7\u03c2 \u03a4SH \u03c3\u03c4\u03bf\u03bd \u03b3\u03b5\u03bd\u03b9\u03ba\u03cc \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03cc \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03c4\u03c5\u03c0\u03b9\u03ba\u03ae \u03ba\u03c9\u03b4\u03c9\u03bd\u03bf\u03b5\u03b9\u03b4\u03ae\u03c2 \u03ba\u03b1\u03bc\u03c0\u03cd\u03bb\u03b7 \u03c4\u03b7\u03c2 \u03ba\u03b1\u03bd\u03bf\u03bd\u03b9\u03ba\u03ae\u03c2 \u03ba\u03b1\u03c4\u03b1\u03bd\u03bf\u03bc\u03ae\u03c2 \u03b1\u03bb\u03bb\u03ac \u03c3\u03ba\u03b5\u03b4\u03ac\u03b6\u03b5\u03b9 \u03c0\u03c1\u03bf\u03c2 \u03c4\u03b1 \u03b1\u03c1\u03b9\u03c3\u03c4\u03b5\u03c1\u03ac \u03b1\u03c0\u03cc \u03b4\u03b9\u03ac\u03c6\u03bf\u03c1\u03b5\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2 \u03bc\u03b5 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b5\u03c1\u03b7 \u03c4\u03b7\u03bd \u03b1\u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03c4\u03b7 \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03b7 \u03bd\u03cc\u03c3\u03bf \u03c4\u03bf\u03c5 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03bf\u03cd\u03c2 (29). \u0395\u03c0\u03bf\u03bc\u03ad\u03bd\u03c9\u03c2 \u03c0\u03b9\u03b8\u03b1\u03bd\u03ac \u03b8\u03b1 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b5\u03c0\u03b1\u03bd\u03b5\u03ba\u03c4\u03b9\u03bc\u03b7\u03b8\u03bf\u03cd\u03bd \u03c4\u03b1 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03cc\u03c1\u03b9\u03b1 \u03c4\u03b7\u03c2 TSH \u03c3\u03c4\u03b7\u03bd \u03c0\u03b1\u03c7\u03c5\u03c3\u03b1\u03c1\u03ba\u03af\u03b1.<\/p>\n<p style=\"text-align: justify;\">\u03a0\u03bf\u03b9\u03bf\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2 \u03c0\u03bf\u03c5 \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03b5 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 TSH \u03c3\u03c4\u03b7\u03bd \u03c0\u03b1\u03c7\u03c5\u03c3\u03b1\u03c1\u03ba\u03af\u03b1 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b3\u03bd\u03c9\u03c3\u03c4\u03cc\u03c2. \u03a3\u03cd\u03bc\u03c6\u03c9\u03bd\u03b1 \u03bc\u03b5 \u03c4\u03b1 \u03c0\u03c1\u03bf\u03b7\u03b3\u03bf\u03cd\u03bc\u03b5\u03bd\u03b1 \u03bc\u03ac\u03bb\u03bb\u03bf\u03bd \u03b7 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03bf\u03c3\u03af\u03b1 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c5\u03c4\u03ae \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af \u03c4\u03b7\u03bd \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 TSH \u03c3\u03c4\u03b1 \u03c0\u03b1\u03c7\u03cd\u03c3\u03b1\u03c1\u03ba\u03b1 \u03ac\u03c4\u03bf\u03bc\u03b1. \u03a3\u03b5 \u03b4\u03b9\u03ac\u03c6\u03bf\u03c1\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b5\u03bd\u03bf\u03c7\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03b5\u03af \u03c4\u03b1 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03bb\u03b5\u03c0\u03c4\u03af\u03bd\u03b7\u03c2 \u03c4\u03b1 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c3\u03c5\u03bd\u03bf\u03b4\u03b5\u03cd\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03c0\u03b1\u03c7\u03c5\u03c3\u03b1\u03c1\u03ba\u03af\u03b1. \u0395\u03af\u03bd\u03b1\u03b9 \u03b3\u03bd\u03c9\u03c3\u03c4\u03cc \u03cc\u03c4\u03b9 \u03c3\u03c4\u03bf\u03bd \u03ac\u03bd\u03b8\u03c1\u03c9\u03c0\u03bf \u03c4\u03bf \u03c0\u03c1\u03bf\u03c6\u03af\u03bb \u03ad\u03ba\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 TSH \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b1\u03c1\u03cc\u03bc\u03bf\u03b9\u03bf \u03bc\u03b5 \u03b1\u03c5\u03c4\u03cc \u03c4\u03b7\u03c2 \u03bb\u03b5\u03c0\u03c4\u03af\u03bd\u03b7\u03c2 \u03c5\u03c0\u03bf\u03b4\u03b7\u03bb\u03ce\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03ad\u03bd\u03b1 \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03c4\u03b9\u03ba\u03cc \u03c1\u03cc\u03bb\u03bf \u03c4\u03b7\u03c2 \u03bb\u03b5\u03c0\u03c4\u03af\u03bd\u03b7\u03c2 \u03c3\u03c4\u03b7\u03bd \u03ad\u03ba\u03ba\u03c1\u03b9\u03c3\u03b7 \u03c4\u03b7\u03c2 TSH (30). \u0397 \u03bb\u03b5\u03c0\u03c4\u03af\u03bd\u03b7 \u03b4\u03b9\u03b5\u03b3\u03b5\u03af\u03c1\u03b5\u03b9 \u03c4\u03b7\u03bd \u03ad\u03ba\u03ba\u03c1\u03b9\u03c3\u03b7 \u03c4\u03bf\u03c5 TRH \u03b5\u03af\u03c4\u03b5 \u03ad\u03bc\u03bc\u03b5\u03c3\u03b1 \u03bc\u03ad\u03c3\u03c9 \u03c4\u03b7\u03c2 \u03c1\u03cd\u03b8\u03bc\u03b9\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd \u03bf\u03c1\u03b5\u03be\u03b9\u03bf\u03b3\u03cc\u03bd\u03c9\u03bd \u03ba\u03b1\u03b9 \u03b1\u03bd\u03bf\u03c1\u03b5\u03be\u03b9\u03bf\u03b3\u03cc\u03bd\u03c9\u03bd \u03bd\u03b5\u03c5\u03c1\u03ce\u03bd\u03c9\u03bd \u03c4\u03bf\u03c5 \u03c4\u03bf\u03be\u03bf\u03b5\u03b9\u03b4\u03bf\u03cd\u03c2 \u03c0\u03c5\u03c1\u03ae\u03bd\u03b1 \u03c4\u03bf\u03c5 \u03c5\u03c0\u03bf\u03b8\u03b1\u03bb\u03ac\u03bc\u03bf\u03c5 \u03bf\u03b9 \u03bd\u03b5\u03c5\u03c1\u03b9\u03ba\u03ad\u03c2 \u03b1\u03c0\u03bf\u03bb\u03ae\u03be\u03b5\u03b9\u03c2 \u03c4\u03c9\u03bd \u03bf\u03c0\u03bf\u03af\u03c9\u03bd \u03c0\u03c1\u03bf\u03b2\u03ac\u03bb\u03bf\u03c5\u03bd \u03c3\u03c4\u03bf\u03bd \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03b9\u03bb\u03b9\u03b1\u03ba\u03cc \u03c0\u03c5\u03c1\u03ae\u03bd\u03b1 \u03b5\u03af\u03c4\u03b5 \u03ac\u03bc\u03b5\u03c3\u03b1 \u03bc\u03ad\u03c3\u03c9 \u03c4\u03b7\u03c2 \u03b4\u03c1\u03ac\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03c3\u03c4\u03bf\u03bd \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03b9\u03bb\u03b9\u03b1\u03ba\u03cc \u03c0\u03c5\u03c1\u03ae\u03bd\u03b1 (31-33). (<b>\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 5<\/b>). \u03a0\u03b1\u03c1\u03cc\u03bb\u03b1 \u03b1\u03c5\u03c4\u03ac \u03b4\u03b5\u03bd \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03c3\u03c5\u03c3\u03c7\u03ad\u03c4\u03b9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b5\u03c0\u03b9\u03c0\u03ad\u03b4\u03c9\u03bd \u03c4\u03b7\u03c2 \u03bb\u03b5\u03c0\u03c4\u03af\u03bd\u03b7\u03c2 \u03bc\u03b5 \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03b7\u03c2 TSH (17). \u03a0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03bf\u03af \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03af \u03bd\u03b1 \u03b5\u03bd\u03ad\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b1\u03c5\u03be\u03bf\u03c1\u03cd\u03b8\u03bc\u03b9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03ad\u03ba\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 TSH \u03c3\u03c4\u03b7\u03bd \u03c0\u03b1\u03c7\u03c5\u03c3\u03b1\u03c1\u03ba\u03af\u03b1, \u03cc\u03c0\u03c9\u03c2 \u03b7 \u03b4\u03c1\u03ac\u03c3\u03b7 \u03c4\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03ba\u03b9\u03bd\u03ce\u03bd \u03b1\u03c0\u03cc \u03c4\u03bf \u03c6\u03bb\u03b5\u03b3\u03bc\u03ad\u03bd\u03bf\u03bd\u03c4\u03b1 \u03bb\u03b9\u03c0\u03ce\u03b4\u03b7 \u03b9\u03c3\u03c4\u03cc, \u03ac\u03bb\u03bb\u03b5\u03c2 \u03bb\u03b9\u03c0\u03bf\u03ba\u03af\u03bd\u03b5\u03c2, \u03b7 \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03b1\u03c3\u03b7 \u03c3\u03c4\u03b7\u03bd \u03b9\u03bd\u03c3\u03bf\u03c5\u03bb\u03af\u03bd\u03b7 \u03ae \u03ba\u03b1\u03b9 \u03b1\u03bb\u03bb\u03b1\u03b3\u03ad\u03c2 \u03c3\u03c4\u03b7\u03bd \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03c9\u03bd \u03b1\u03c0\u03bf\u03b9\u03c9\u03b4\u03b9\u03bd\u03b1\u03c3\u03ce\u03bd. \u0394\u03b9\u03ac\u03c6\u03bf\u03c1\u03b5\u03c2 in vitro \u03ba\u03b1\u03b9 in vivo \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c3\u03b5 \u03c0\u03b5\u03b9\u03c1\u03b1\u03bc\u03b1\u03c4\u03cc\u03b6\u03c9\u03b1 \u03c3\u03c4\u03b7\u03bd \u03c0\u03b1\u03c7\u03c5\u03c3\u03b1\u03c1\u03ba\u03af\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b4\u03c1\u03ac\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b1\u03c0\u03bf\u03b9\u03c9\u03b4\u03b9\u03bd\u03b1\u03c3\u03c9\u03bd \u03c3\u03c4\u03b7\u03bd \u03c0\u03b1\u03c7\u03c5\u03c3\u03b1\u03c1\u03ba\u03af\u03b1 \u03bc\u03b5 \u03b1\u03bd\u03c4\u03b9\u03ba\u03c1\u03bf\u03c5\u03cc\u03bc\u03b5\u03bd\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 (34-36). \u03a0\u03c1\u03cc\u03c3\u03c6\u03b1\u03c4\u03b1 \u03c3\u03b5 \u03bc\u03b9\u03b1 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03bf\u03ba\u03b9\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c4\u03b7\u03c2 \u03bb\u03b5\u03b2\u03bf\u03b8\u03c5\u03c1\u03bf\u03be\u03af\u03bd\u03b7\u03c2 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03c3\u03bf\u03b2\u03b1\u03c1\u03ae \u03c0\u03b1\u03c7\u03c5\u03c3\u03b1\u03c1\u03ba\u03af\u03b1 \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03b7\u03c2 \u03a43 \u03bf\u03c1\u03bf\u03cd, \u03bc\u03b5\u03b9\u03ce\u03b8\u03b7\u03ba\u03b1\u03bd 2 \u03ce\u03c1\u03b5\u03c2 \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 600 \u03bcg \u03b4\u03b9\u03b1\u03bb\u03cd\u03bc\u03b1\u03c4\u03bf\u03c2 LT4 \u03c3\u03b5 \u03b1\u03bd\u03c4\u03af\u03b8\u03b5\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03bf\u03c5\u03c2 \u03bd\u03bf\u03c1\u03bc\u03bf\u03b2\u03b1\u03c1\u03b5\u03af\u03c2 \u03bc\u03ac\u03c1\u03c4\u03c5\u03c1\u03b5\u03c2 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03bf\u03c0\u03bf\u03af\u03bf\u03c5\u03c2 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03ae\u03b8\u03b7\u03ba\u03b5 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5\u03c2 \u03c4\u03b7\u03bd \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03bf\u03b9\u03c7\u03b7 \u03c7\u03c1\u03bf\u03bd\u03b9\u03ba\u03ae \u03c0\u03b5\u03c1\u03af\u03bf\u03b4\u03bf. \u03a4\u03bf \u03b5\u03cd\u03c1\u03b7\u03bc\u03b1 \u03b1\u03c5\u03c4\u03cc \u03b8\u03b1 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03c3\u03b5 \u03bd\u03b1 \u03b1\u03c0\u03bf\u03b4\u03bf\u03b8\u03b5\u03af \u03c3\u03b5 \u03bc\u03b5\u03b9\u03bf\u03bd\u03b5\u03ba\u03c4\u03b9\u03ba\u03ae \u03c0\u03b5\u03c1\u03b9\u03c6\u03b5\u03c1\u03b9\u03ba\u03ae \u03bc\u03b5\u03c4\u03b1\u03c4\u03c1\u03bf\u03c0\u03ae \u03c4\u03b7\u03c2 \u03a44 \u03c3\u03b5 \u03a43 \u03c3\u03c4\u03b7 \u03c3\u03bf\u03b2\u03b1\u03c1\u03ae \u03c0\u03b1\u03c7\u03c5\u03c3\u03b1\u03c1\u03ba\u03af\u03b1 (37).<\/p>\n<hr style=\"width: 100%; border-width: 1px; border-style: solid; border-color: #CCCCCC; color: #ffffff;\" noshade=\"noshade\" width=\"100%\" \/>\n<p style=\"text-align: justify;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-845\" alt=\"10.27-figure5\" src=\"https:\/\/e-endocrinology.gr\/wp-content\/uploads\/2014\/10\/10.27-figure5.jpg\" width=\"486\" height=\"466\" srcset=\"https:\/\/e-endocrinology.gr\/wp-content\/uploads\/2014\/10\/10.27-figure5.jpg 486w, https:\/\/e-endocrinology.gr\/wp-content\/uploads\/2014\/10\/10.27-figure5-300x287.jpg 300w\" sizes=\"(max-width: 486px) 100vw, 486px\" \/><\/p>\n<p style=\"text-align: justify;\">\n<p style=\"text-align: justify;\"><em><strong>\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 5.<\/strong><\/em> \u0397 \u03bb\u03b5\u03c0\u03c4\u03af\u03bd\u03b7 \u03b4\u03b9\u03b5\u03b3\u03b5\u03af\u03c1\u03b5\u03b9 \u03c4\u03b7\u03bd \u03ad\u03ba\u03ba\u03c1\u03b9\u03c3\u03b7 TRH \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03b9\u03bb\u03b9\u03b1\u03ba\u03cc \u03c0\u03c5\u03c1\u03ae\u03bd\u03b1 \u03ba\u03b1\u03b9 \u03b7 TSH \u03b4\u03b9\u03b5\u03b3\u03b5\u03af\u03c1\u03b5\u03b9 \u03c4\u03b7\u03bd \u03ad\u03ba\u03ba\u03c1\u03b9\u03c3\u03b7 \u03bb\u03b5\u03c0\u03c4\u03af\u03bd\u03b7\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf \u03bb\u03b5\u03c5\u03ba\u03cc \u03bb\u03b9\u03c0\u03ce\u03b4\u03b7 \u03b9\u03c3\u03c4\u03cc (31).<\/p>\n<hr style=\"width: 100%; border-width: 1px; border-style: solid; border-color: #CCCCCC; color: #ffffff;\" noshade=\"noshade\" width=\"100%\" \/>\n<h4 style=\"text-align: justify;\"><b>5. \u03a3\u03c5\u03bc\u03c0\u03b5\u03c1\u03ac\u03c3\u03bc\u03b1\u03c4\u03b1 <\/b><\/h4>\n<p style=\"text-align: justify;\">\u03a0\u03b5\u03c1\u03b9\u03b3\u03c1\u03ac\u03c6\u03b7\u03ba\u03b1\u03bd \u03c4\u03b1 \u03c3\u03c0\u03bf\u03c5\u03b4\u03b1\u03b9\u03cc\u03c4\u03b5\u03c1\u03b1 \u03b5\u03c5\u03c1\u03ae\u03bc\u03b1\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2 \u03c3\u03c4\u03b7\u03bd \u03c3\u03bf\u03b2\u03b1\u03c1\u03ae \u03c0\u03b1\u03c7\u03c5\u03c3\u03b1\u03c1\u03ba\u03af\u03b1. \u0397 \u03c5\u03c0\u03bf\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03c4\u03bf\u03c5 \u0398\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03bf\u03cd\u03c2, \u03ad\u03c3\u03c4\u03c9 \u03ba\u03b1\u03b9 \u03c3\u03bf\u03b2\u03b1\u03c1\u03ae, \u03b4\u03b5\u03bd \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af \u03bf\u03c5\u03c3\u03b9\u03b1\u03c3\u03c4\u03b9\u03ba\u03ae \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b2\u03ac\u03c1\u03bf\u03c5\u03c2 \u03c0\u03ad\u03c1\u03b1\u03bd \u03c4\u03c9\u03bd \u03bb\u03af\u03b3\u03c9\u03bd \u03c7\u03b9\u03bb\u03b9\u03cc\u03b3\u03c1\u03b1\u03bc\u03bc\u03c9\u03bd, \u03c0\u03bf\u03c5 \u03bf\u03c6\u03b5\u03af\u03bb\u03b5\u03c4\u03b1\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c3\u03c4\u03b7\u03bd \u03ba\u03b1\u03c4\u03b1\u03ba\u03c1\u03ac\u03c4\u03b7\u03c3\u03b7 \u03cd\u03b4\u03b1\u03c4\u03bf\u03c2. \u0397 \u03bc\u03b9\u03ba\u03c1\u03ae \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03a4SH \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03bd \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b5\u03c0\u03b1\u03bd\u03b1\u03c0\u03c1\u03bf\u03c3\u03b4\u03b9\u03bf\u03c1\u03b9\u03c3\u03bc\u03bf\u03cd \u03c4\u03bf\u03cd \u03bf\u03c5\u03b4\u03bf\u03cd \u03b5\u03ba\u03ba\u03c1\u03af\u03c3\u03b5\u03c9\u03c2 \u03c4\u03b7\u03c2 TSH (reset point). \u03a3\u03c5\u03bd\u03c5\u03c0\u03ac\u03c1\u03c7\u03c9\u03bd \u03c5\u03c0\u03bf\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03c3\u03bc\u03cc\u03c2 \u03b2\u03b5\u03b2\u03b1\u03b9\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c4\u03b9\u03bc\u03ce\u03bd \u03c4\u03b7\u03c2 TSH \u03c0\u03ad\u03c1\u03b1\u03bd \u03c4\u03c9\u03bd \u03c0\u03b1\u03c1\u03b1\u03b4\u03b5\u03ba\u03c4\u03ce\u03bd \u03b1\u03bd\u03c9\u03c4\u03ac\u03c4\u03c9\u03bd \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ce\u03bd \u03bf\u03c1\u03af\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03cd\u03c0\u03b1\u03c1\u03be\u03b7 \u03b8\u03b5\u03c4\u03b9\u03ba\u03ce\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd. \u0388\u03c4\u03c3\u03b9 \u03c3\u03ae\u03bc\u03b5\u03c1\u03b1, \u03b4\u03b5\u03bd \u03c3\u03c5\u03bd\u03b9\u03c3\u03c4\u03ac\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c4\u03b7\u03c2 \u03c0\u03b1\u03c7\u03c5\u03c3\u03b1\u03c1\u03ba\u03af\u03b1\u03c2 \u03b7 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03bf\u03c1\u03bc\u03bf\u03bd\u03ce\u03bd (38), \u03b1\u03bd \u03ba\u03b1\u03b9 \u03b3\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7\u03c2 \u03b5\u03ba\u03bb\u03b5\u03ba\u03c4\u03b9\u03ba\u03ce\u03bd \u03b1\u03b3\u03c9\u03bd\u03b9\u03c3\u03c4\u03ce\u03bd \u03c4\u03bf\u03c5 \u03b2-\u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03c4\u03b7\u03c2 \u03a43 \u03c3\u03b5 \u03c0\u03b5\u03b9\u03c1\u03b1\u03bc\u03b1\u03c4\u03cc\u03b6\u03c9\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c3\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03bf\u03cd \u03b2\u03ac\u03c1\u03bf\u03c5\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03bb\u03b9\u03c0\u03ce\u03b4\u03bf\u03c5\u03c2 \u03bc\u03ac\u03b6\u03b1\u03c2 \u03bc\u03b5 \u03b5\u03bd\u03b8\u03b1\u03c1\u03c1\u03c5\u03bd\u03c4\u03b9\u03ba\u03ac \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 (39).<\/p>\n<h4 style=\"text-align: justify;\">\u0392\u03b9\u03b2\u03bb\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1<\/h4>\n<p style=\"text-align: left;\">1. Harper ME, Seifert EL. Thyroid hormone effects on mitochondrial energetics. Thyroid : official journal of the American Thyroid Association. 2008; 18:145-156.<br \/>\n2. Lowell BB, Spiegelman BM. Towards a molecular understanding of adaptive thermogenesis. Nature. 2000; 404:652-660.<br \/>\n3. Kim B. Thyroid hormone as a determinant of energy expenditure and the basal metabolic rate. Thyroid : official journal of the American Thyroid Association. 2008; 18:141-144.<br \/>\n4. Silva JE. Thermogenic mechanisms and their hormonal regulation. Physiological reviews. 2006; 86:435-464.<br \/>\n5. Lopez M, Varela L, Vazquez MJ, et al. Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance. Nature medicine. 2010; 16:1001-1008.<br \/>\n6. Cannon B, Nedergaard J. Thyroid hormones: igniting brown fat via the brain. Nature medicine. 2010; 16:965-967.<br \/>\n7. Silva JE, Bianco SD. Thyroid-adrenergic interactions: physiological and clinical implications. Thyroid : official journal of the American Thyroid Association. 2008; 18:157-165.<br \/>\n8. Ishii S, Kamegai J, Tamura H, et al. Triiodothyronine (T3) stimulates food intake via enhanced hypothalamic AMP-activated kinase activity. Regulatory peptides. 2008; 151:164-169.<br \/>\n9. Kong WM, Martin NM, Smith KL, et al. Triiodothyronine stimulates food intake via the hypothalamic ventromedial nucleus independent of changes in energy expenditure. Endocrinology. 2004; 145:5252-5258.<br \/>\n10. Karmisholt J, Andersen S, Laurberg P. Weight loss after therapy of hypothyroidism is mainly caused by excretion of excess body water associated with myxoedema. The Journal of clinical endocrinology and metabolism. 2011; 96:E99-103.<br \/>\n11. al-Adsani H, Hoffer LJ, Silva JE. Resting energy expenditure is sensitive to small dose changes in patients on chronic thyroid hormone replacement. The Journal of clinical endocrinology and metabolism. 1997; 82:1118-1125.<br \/>\n12. Kong WM, Sheikh MH, Lumb PJ, et al. A 6-month randomized trial of thyroxine treatment in women with mild subclinical hypothyroidism. The American journal of medicine. 2002; 112:348-354.<br \/>\n13. Knudsen N, Laurberg P, Rasmussen LB, et al. Small differences in thyroid function may be important for body mass index and the occurrence of obesity in the population. The Journal of clinical endocrinology and metabolism. 2005; 90:4019-4024.<br \/>\n14. Wolf M, Weigert A, Kreymann G. Body composition and energy expenditure in thyroidectomized patients during short-term hypothyroidism and thyrotropin-suppressive thyroxine therapy. European journal of endocrinology \/ European Federation of Endocrine Societies. 1996; 134:168-173.<br \/>\n15. Portmann L, Giusti V. (Obesity and hypothyroidism: myth or reality?). Revue medicale suisse. 2007; 3:859-862.<br \/>\n16. Danforth E, Jr., Horton ES, O&#8217;Connell M, et al. Dietary-induced alterations in thyroid hormone metabolism during overnutrition. The Journal of clinical investigation. 1979; 64:1336-1347.<br \/>\n17. Michalaki MA, Vagenakis AG, Leonardou AS, et al. Thyroid function in humans with morbid obesity. Thyroid : official journal of the American Thyroid Association. 2006; 16:73-78.<br \/>\n18. Rotondi M, Leporati P, La Manna A, et al. Raised serum TSH levels in patients with morbid obesity: is it enough to diagnose subclinical hypothyroidism? European journal of endocrinology \/ European Federation of Endocrine Societies. 2009; 160:403-408.<br \/>\n19. Asvold BO, Bjoro T, Vatten LJ. Association of serum TSH with high body mass differs between smokers and never-smokers. The Journal of clinical endocrinology and metabolism. 2009; 94:5023-5027.<br \/>\n20. Sari R, Balci MK, Altunbas H, et al. The effect of body weight and weight loss on thyroid volume and function in obese women. Clinical endocrinology. 2003; 59:258-262.<br \/>\n21. Marzullo P, Minocci A, Tagliaferri MA, et al. Investigations of thyroid hormones and antibodies in obesity: leptin levels are associated with thyroid autoimmunity independent of bioanthropometric, hormonal, and weight-related determinants. The Journal of clinical endocrinology and metabolism. 2010; 95:3965-3972.<br \/>\n22. Kok P, Roelfsema F, Frolich M, et al. Spontaneous diurnal thyrotropin secretion is enhanced in proportion to circulating leptin in obese premenopausal women. The Journal of clinical endocrinology and metabolism. 2005; 90:6185-6191.<br \/>\n23. Lips MA, Pijl H, van Klinken JB, et al. Roux-en-Y gastric bypass and calorie restriction induce comparable time-dependent effects on thyroid hormone function tests in obese female subjects. European journal of endocrinology \/ European Federation of Endocrine Societies. 2013; 169:339-347.<br \/>\n24. Kok P, Roelfsema F, Langendonk JG, et al. High circulating thyrotropin levels in obese women are reduced after body weight loss induced by caloric restriction. The Journal of clinical endocrinology and metabolism. 2005; 90:4659-4663.<br \/>\n25. Wesche MF, Wiersinga WM, Smits NJ. Lean body mass as a determinant of thyroid size. Clinical endocrinology. 1998; 48:701-706.<br \/>\n26. Rotondi M, Cappelli C, Leporati P, et al. A hypoechoic pattern of the thyroid at ultrasound does not indicate autoimmune thyroid diseases in patients with morbid obesity. European journal of endocrinology \/ European Federation of Endocrine Societies. 2010; 163:105-109.<br \/>\n27. Radetti G, Kleon W, Buzi F, et al. Thyroid function and structure are affected in childhood obesity. The Journal of clinical endocrinology and metabolism. 2008; 93:4749-4754.<br \/>\n28. Rapa A, Monzani A, Moia S, et al. Subclinical hypothyroidism in children and adolescents: a wide range of clinical, biochemical, and genetic factors involved. The Journal of clinical endocrinology and metabolism. 2009; 94:2414-2420.<br \/>\n29. Wartofsky L, Dickey RA. The evidence for a narrower thyrotropin reference range is compelling. The Journal of clinical endocrinology and metabolism. 2005; 90:5483-5488.<br \/>\n30. Mantzoros CS, Ozata M, Negrao AB, et al. Synchronicity of frequently sampled thyrotropin (TSH) and leptin concentrations in healthy adults and leptin-deficient subjects: evidence for possible partial TSH regulation by leptin in humans. The Journal of clinical endocrinology and metabolism. 2001; 86:3284-3291.<br \/>\n31. Duntas LH, Biondi B. The interconnections between obesity, thyroid function, and autoimmunity: the multifold role of leptin. Thyroid : official journal of the American Thyroid Association. 2013; 23:646-653.<br \/>\n32. Guo F, Bakal K, Minokoshi Y, et al. Leptin signaling targets the thyrotropin-releasing hormone gene promoter in vivo. Endocrinology. 2004; 145:2221-2227.<br \/>\n33. Lechan RM, Fekete C. The TRH neuron: a hypothalamic integrator of energy metabolism. Progress in brain research. 2006; 153:209-235.<br \/>\n34. Ortega FJ, Jilkova ZM, Moreno-Navarrete JM, et al. Type I iodothyronine 5&#8242;-deiodinase mRNA and activity is increased in adipose tissue of obese subjects. International journal of obesity. 2012; 36:320-324.<br \/>\n35. Katzeff HL, Selgrad C. Impaired peripheral thyroid hormone metabolism in genetic obesity. Endocrinology. 1993; 132:989-995.<br \/>\n36. Pihlajamaki J, Boes T, Kim EY, et al. Thyroid hormone-related regulation of gene expression in human fatty liver. The Journal of clinical endocrinology and metabolism. 2009; 94:3521-3529.<br \/>\n37. Michalaki MA, Gkotsina MI, Mamali I, et al. Impaired pharmacokinetics of levothyroxine in severely obese volunteers. Thyroid : official journal of the American Thyroid Association. 2011; 21:477-481.<br \/>\n38. Kaptein EM, Beale E, Chan LS. Thyroid hormone therapy for obesity and nonthyroidal illnesses: a systematic review. The Journal of clinical endocrinology and metabolism. 2009; 94:3663-3675.<br \/>\n39. Bryzgalova G, Effendic S, Khan A, et al. Anti-obesity, anti-diabetic, and lipid lowering effects of the thyroid receptor beta subtype selective agonist KB-141. The Journal of steroid biochemistry and molecular biology. 2008; 111:262-267.<\/p>\n<hr style=\"width: 100%; border-width: 1px; border-style: solid; border-color: #CCCCCC; color: #ffffff;\" noshade=\"noshade\" width=\"100%\" \/>\n<p style=\"text-align: justify;\">Created: October 28, 2014<br \/>\nLast update: October 28, 2014<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u039c. \u039c\u03b9\u03c7\u03b1\u03bb\u03ac\u03ba\u03b7 \u0395\u03c0\u03b9\u03bc\u03b5\u03bb\u03ae\u03c4\u03c1\u03b9\u03b1 \u0391\u2019, \u0395\u03bd\u03b4\u03bf\u03ba\u03c1\u03b9\u03bd\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03a4\u03bc\u03ae\u03bc\u03b1, \u03a0\u03b1\u03bd\u03b5\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03b9\u03b1\u03ba\u03ae \u03a0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae, \u03a0\u03b1\u03bd\u03b5\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03b9\u03b1\u03ba\u03cc \u0393\u03b5\u03bd\u03b9\u03ba\u03cc \u039d\u03bf\u03c3\u03bf\u03ba\u03bf\u03bc\u03b5\u03af\u03bf \u03a0\u03b1\u03c4\u03c1\u03ce\u03bd \u0391.\u0393. \u0392\u03b1\u03b3\u03b5\u03bd\u03ac\u03ba\u03b7\u03c2 \u039f\u03bc\u03cc\u03c4\u03b9\u03bc\u03bf\u03c2 \u039a\u03b1\u03b8\u03b7\u03b3\u03b7\u03c4\u03ae\u03c2 \u0395\u03bd\u03b4\u03bf\u03ba\u03c1\u03b9\u03bd\u03bf\u03bb\u03bf\u03b3\u03af\u03b1\u03c2-\u03a0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03af\u03b1\u03c2 \u03a0\u03b1\u03bd\u03b5\u03c0\u03b9\u03c3\u03c4\u03ae\u03bc\u03b9\u03bf \u03a0\u03b1\u03c4\u03c1\u03ce\u03bd \u0395\u03b9\u03c3\u03b1\u03b3\u03c9\u03b3\u03ae \u0397 \u03c0\u03b1\u03c7\u03c5\u03c3\u03b1\u03c1\u03ba\u03af\u03b1 \u03b1\u03bd\u03b1\u03c6\u03ad\u03c1\u03b5\u03c4\u03b1\u03b9 \u03c9\u03c2 \u03b7 \u03b5\u03c0\u03b9\u03b4\u03b7\u03bc\u03af\u03b1 \u03c4\u03b7\u03c2 \u03b5\u03c0\u03bf\u03c7\u03ae\u03c2 \u03bc\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bd\u03bf\u03b4\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03bd\u03bf\u03c3\u03b7\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03b8\u03bd\u03b7\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1 \u03bc\u03ad\u03c3\u03c9 \u03c4\u03c9\u03bd \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03ce\u03bd \u03c3\u03c5\u03bd-\u03bd\u03bf\u03c3\u03b7\u03c1\u03bf\u03c4\u03ae\u03c4\u03c9\u03bd \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af. \u0397 \u03c0\u03b1\u03c7\u03c5\u03c3\u03b1\u03c1\u03ba\u03af\u03b1 \u03bf\u03c6\u03b5\u03af\u03bb\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ac \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03c0\u03b5\u03c1\u03b9\u03b2\u03b1\u03bb\u03bb\u03bf\u03bd\u03c4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03b1\u03af\u03c4\u03b9\u03b1. \u0397 \u03bf\u03bc\u03bf\u03b9\u03bf\u03c3\u03c4\u03b1\u03c3\u03af\u03b1 \u03c4\u03b7\u03c2 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"pageCustom.php","meta":{"footnotes":""},"tags":[],"_links":{"self":[{"href":"https:\/\/e-endocrinology.gr\/index.php?rest_route=\/wp\/v2\/pages\/840"}],"collection":[{"href":"https:\/\/e-endocrinology.gr\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/e-endocrinology.gr\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/e-endocrinology.gr\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/e-endocrinology.gr\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=840"}],"version-history":[{"count":3,"href":"https:\/\/e-endocrinology.gr\/index.php?rest_route=\/wp\/v2\/pages\/840\/revisions"}],"predecessor-version":[{"id":847,"href":"https:\/\/e-endocrinology.gr\/index.php?rest_route=\/wp\/v2\/pages\/840\/revisions\/847"}],"wp:attachment":[{"href":"https:\/\/e-endocrinology.gr\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=840"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/e-endocrinology.gr\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=840"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}