{"id":826,"date":"2014-10-27T23:06:41","date_gmt":"2014-10-27T20:06:41","guid":{"rendered":"http:\/\/e-endocrinology.gr\/?page_id=826"},"modified":"2015-02-18T15:14:23","modified_gmt":"2015-02-18T12:14:23","slug":"10-26-%cf%83%cf%8d%ce%bd%ce%b4%cf%81%ce%bf%ce%bc%ce%bf-%cf%84%ce%b7%cf%82-%ce%bc%ce%b7-%ce%b8%cf%85%cf%81%ce%b5%ce%bf%ce%b5%ce%b9%ce%b4%ce%b9%ce%ba%ce%ae%cf%82-%ce%bd%cf%8c%cf%83%ce%bf%cf%85","status":"publish","type":"page","link":"https:\/\/e-endocrinology.gr\/?page_id=826","title":{"rendered":"10.26 \u03a3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf \u03c4\u03b7\u03c2 \u03bc\u03b7 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5"},"content":{"rendered":"

\n \n \"Print\n <\/a>\n <\/div><\/p>\n


<\/p>\n

\u039c. \u039c\u03b9\u03c7\u03b1\u03bb\u03ac\u03ba\u03b7<\/em>
\n\u0395\u03c0\u03b9\u03bc\u03b5\u03bb\u03ae\u03c4\u03c1\u03b9\u03b1 \u0391\u2019, \u0395\u03bd\u03b4\u03bf\u03ba\u03c1\u03b9\u03bd\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03a4\u03bc\u03ae\u03bc\u03b1, \u03a0\u03b1\u03bd\u03b5\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03b9\u03b1\u03ba\u03ae \u03a0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae,
\n\u03a0\u03b1\u03bd\u03b5\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03b9\u03b1\u03ba\u03cc \u0393\u03b5\u03bd\u03b9\u03ba\u03cc \u039d\u03bf\u03c3\u03bf\u03ba\u03bf\u03bc\u03b5\u03af\u03bf \u03a0\u03b1\u03c4\u03c1\u03ce\u03bd
\n\u0391.\u0393. \u0392\u03b1\u03b3\u03b5\u03bd\u03ac\u03ba\u03b7\u03c2<\/em>
\n\u039f\u03bc\u03cc\u03c4\u03b9\u03bc\u03bf\u03c2 \u039a\u03b1\u03b8\u03b7\u03b3\u03b7\u03c4\u03ae\u03c2 \u0395\u03bd\u03b4\u03bf\u03ba\u03c1\u03b9\u03bd\u03bf\u03bb\u03bf\u03b3\u03af\u03b1\u03c2-\u03a0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03af\u03b1\u03c2, \u03a0\u03b1\u03bd\u03b5\u03c0\u03b9\u03c3\u03c4\u03ae\u03bc\u03b9\u03bf \u03a0\u03b1\u03c4\u03c1\u03ce\u03bd<\/p>\n

<\/h4>\n

\u00a01. <\/b>\u039f\u03c1\u03b9\u03c3\u03bc\u03cc\u03c2 \u2013 \u039a\u03b1\u03c4\u03b1\u03c3\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c3\u03c4\u03b9\u03c2 \u03bf\u03c0\u03bf\u03af\u03b5\u03c2 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b5\u03af\u03c4\u03b1\u03b9<\/b><\/h4>\n

\u03a4\u03bf \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf \u03c4\u03b7\u03c2 \u03bc\u03b7 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5 (\u039c\u0398\u039d) \u03c0\u03b5\u03c1\u03b9\u03b5\u03b3\u03c1\u03ac\u03c6\u03b5\u03b9 \u03b3\u03b9\u03b1 \u03c0\u03c1\u03ce\u03c4\u03b7 \u03c6\u03bf\u03c1\u03ac \u03c4\u03bf 1963 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd Oppenheimer (1) \u03ba\u03b1\u03b9 \u03b1\u03c6\u03bf\u03c1\u03ac \u03c4\u03b9\u03c2 \u03c0\u03b1\u03c1\u03bf\u03b4\u03b9\u03ba\u03ad\u03c2 \u03b1\u03bb\u03bb\u03b1\u03b3\u03ad\u03c2 \u03c4\u03c9\u03bd \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03c4\u03c1\u03c9\u03bd \u03c4\u03b7\u03c2 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2 \u03bf\u03b9 \u03bf\u03c0\u03bf\u03af\u03b5\u03c2 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03bf\u03c5 \u03bd\u03bf\u03c3\u03bf\u03cd\u03bd \u03b1\u03c0\u03bf \u03bc\u03b7 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03cc \u03bd\u03cc\u03c3\u03b7\u03bc\u03b1. \u0395\u03c0\u03af\u03c3\u03b7\u03c2 \u03b1\u03bd\u03b1\u03c6\u03ad\u03c1\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03b2\u03b9\u03b2\u03bb\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1 \u03c9\u03c2 \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf \u03c4\u03b7\u03c2 \u03c7\u03b1\u03bc\u03b7\u03bb\u03ae\u03c2 \u03a43 (low T3 syndrome) \u03ba\u03b1\u03b8\u03ce\u03c2 \u03ba\u03b1\u03b9 \u03c9\u03c2 \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf \u03c4\u03bf\u03c5 \u03bd\u03bf\u03c3\u03bf\u03cd\u03bd\u03c4\u03bf\u03c2 \u03b5\u03c5\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03bf\u03cd (euthyroid sick syndrome) (2). \u039f \u03c4\u03b5\u03bb\u03b5\u03c5\u03c4\u03b1\u03af\u03bf\u03c2 \u03cc\u03c1\u03bf\u03c2 \u03b4\u03b5\u03bd \u03b8\u03b5\u03c9\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03c0\u03bb\u03ad\u03bf\u03bd \u03b4\u03cc\u03ba\u03b9\u03bc\u03bf\u03c2 \u03b1\u03c6\u03bf\u03cd \u03c0\u03c1\u03bf\u03cb\u03c0\u03bf\u03b8\u03ad\u03c4\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03bf \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03c5\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03cc\u03c2, \u03ba\u03b1\u03c4\u03b9 \u03cc\u03bc\u03c9\u03c2 \u03c0\u03bf\u03c5 \u03cc\u03c0\u03c9\u03c2 \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c0\u03c1\u03cc\u03c3\u03c6\u03b1\u03c4\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2, \u03bc\u03ac\u03bb\u03bb\u03bf\u03bd \u03b4\u03b5\u03bd \u03b9\u03c3\u03c7\u03cd\u03b5\u03b9. \u0391\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03b2\u03b9\u03bf\u03c7\u03b7\u03bc\u03b9\u03ba\u03cc \u03bf\u03c1\u03b9\u03c3\u03bc\u03cc \u03ba\u03b1\u03b9 \u03b4\u03b5\u03bd \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03b9 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03c3\u03b7\u03bc\u03b5\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1. \u039f\u03c5\u03c3\u03b9\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03ba\u03ac\u03b8\u03b5 \u03c6\u03bf\u03c1\u03ac \u03c0\u03bf\u03c5 \u03bf \u03bf\u03c1\u03b3\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2 \u03c5\u03c6\u03af\u03c3\u03c4\u03b1\u03c4\u03b1\u03b9 \u03ba\u03ac\u03c0\u03bf\u03b9\u03bf \u03bf\u03c1\u03b3\u03b1\u03bd\u03b9\u03ba\u03cc \u03c3\u03c4\u03c1\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c0\u03bf\u03bb\u03bb\u03bf\u03cd\u03c2 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03ad\u03c2 \u03b8\u03b5\u03c9\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03c0\u03c1\u03bf\u03c3\u03b1\u03c1\u03bc\u03bf\u03b3\u03ae \u03c3\u03b5 \u03b1\u03c5\u03c4\u03cc. \u03a0\u03b9\u03bf \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b1, \u03ba\u03ac\u03b8\u03b5 \u03c6\u03bf\u03c1\u03ac \u03c0\u03bf\u03c5 \u03b7 \u03bf\u03bc\u03bf\u03b9\u03cc\u03c3\u03c4\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03bf\u03c1\u03b3\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03cd \u03b1\u03c0\u03b5\u03b9\u03bb\u03b5\u03af\u03c4\u03b1\u03b9 \u03bf \u03bf\u03c1\u03b3\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2 \u03b1\u03c0\u03b1\u03bd\u03c4\u03ac \u03bc\u03b5 \u03bc\u03b9\u03b1 \u00ab\u03bf\u03bb\u03b9\u03c3\u03c4\u03b9\u03ba\u03ae\u00bb \u03bd\u03b5\u03c5\u03c1\u03bf\u03b5\u03bd\u03b4\u03bf\u03ba\u03c1\u03b9\u03bd\u03b9\u03ba\u03ae \u03b1\u03c0\u03ac\u03bd\u03c4\u03b7\u03c3\u03b7 \u03c0\u03c1\u03bf\u03ba\u03b5\u03b9\u03bc\u03ad\u03bd\u03bf\u03c5 \u03bd\u03b1 \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03c9\u03c0\u03af\u03c3\u03b5\u03b9 \u03c4\u03bf\u03bd \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf. \u039a\u03b1\u03c4\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03b5\u03b9 \u03b1\u03c6\u2019 \u03b5\u03bd\u03cc\u03c2 \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03c4\u03b7\u03c2 \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03cd\u03c2 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae\u03c2 \u03bf\u03c1\u03bc\u03cc\u03bd\u03b7\u03c2 T3, \u03c4\u03b7\u03bd \u03b3\u03bf\u03bd\u03b1\u03b4\u03b9\u03ba\u03ae \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03ba\u03b1\u03b9 \u03ad\u03c4\u03c3\u03b9 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03b5\u03c3\u03c4\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7\u03c2 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03ac\u03bd\u03b4\u03c1\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03bf\u03b9\u03c3\u03c4\u03c1\u03b1\u03b4\u03b9\u03cc\u03bb\u03b7\u03c2 \u03c3\u03c4\u03b9\u03c2 \u03b3\u03c5\u03bd\u03b1\u03af\u03ba\u03b5\u03c2 \u03ba\u03b1\u03b8\u03ce\u03c2 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03bf\u03bd \u03b1\u03c5\u03be\u03b7\u03c4\u03b9\u03ba\u03cc \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1 IGF-I \u03c0\u03c1\u03bf\u03ba\u03b5\u03b9\u03bc\u03ad\u03bd\u03bf\u03c5 \u03bd\u03b1 \u03b5\u03be\u03bf\u03b9\u03ba\u03bf\u03bd\u03bf\u03bc\u03ae\u03c3\u03b5\u03b9 \u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03b1\u03c6\u2019 \u03b5\u03c4\u03ad\u03c1\u03bf\u03c5 \u03b4\u03b9\u03b5\u03b3\u03b5\u03af\u03c1\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03ad\u03ba\u03ba\u03c1\u03b9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03b4\u03c1\u03b5\u03bd\u03b1\u03bb\u03af\u03bd\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03ba\u03bf\u03c1\u03c4\u03b9\u03b6\u03cc\u03bb\u03b7\u03c2, \u03bf\u03c1\u03bc\u03bf\u03bd\u03ce\u03bd \u03c0\u03bf\u03c5 \u03b8\u03b5\u03c9\u03c1\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03b1\u03c1\u03b1\u03af\u03c4\u03b7\u03c4\u03b5\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03bc\u03ac\u03c7\u03b7 \u03c4\u03b7\u03c2 \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7\u03c2. \u03a4\u03bf \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf \u03ad\u03c7\u03b5\u03b9 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b7\u03b8\u03b5\u03af \u03c3\u03b5 \u03bd\u03b7\u03c3\u03c4\u03b5\u03af\u03b1 \u03ba\u03b1\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c3\u03b5 \u03c3\u03c4\u03ad\u03c1\u03b7\u03c3\u03b7 \u03c5\u03b4\u03b1\u03c4\u03b1\u03bd\u03b8\u03c1\u03ac\u03ba\u03c9\u03bd, \u03c3\u03c4\u03b7\u03bd \u03c3\u03ae\u03c8\u03b7-\u03c3\u03b7\u03c0\u03c4\u03b9\u03ba\u03cc shock, \u03c3\u03b5 \u03b2\u03b1\u03c1\u03ad\u03c9\u03c2 \u03c0\u03ac\u03c3\u03c7\u03bf\u03bd\u03c4\u03b5\u03c2, \u03bf\u03be\u03ad\u03b1 \u03b5\u03bc\u03c6\u03c1\u03ac\u03b3\u03bc\u03b1\u03c4\u03b1 \u03c4\u03bf\u03c5 \u03bc\u03c5\u03bf\u03ba\u03b1\u03c1\u03b4\u03af\u03bf\u03c5, \u03c7\u03b5\u03b9\u03c1\u03bf\u03c5\u03c1\u03b3\u03b5\u03af\u03b1, \u03c4\u03c1\u03b1\u03cd\u03bc\u03b1\u03c4\u03b1, \u03b4\u03b9\u03b1\u03b2\u03b7\u03c4\u03b9\u03ba\u03ae \u03ba\u03b5\u03c4\u03bf\u03be\u03ad\u03c9\u03c3\u03b7, \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1, \u03b7\u03c0\u03b1\u03c4\u03b9\u03ba\u03ae \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1, \u03b5\u03b3\u03ba\u03b1\u03cd\u03bc\u03b1\u03c4\u03b1, \u03c8\u03c5\u03c7\u03c9\u03c3\u03b9\u03ba\u03ad\u03c2 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ad\u03c2, \u03bb\u03bf\u03af\u03bc\u03c9\u03be\u03b7 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd \u03b9\u03cc \u03c4\u03bf\u03c5 AIDS \u03ba\u03b1\u03b9 \u03c4\u03b5\u03bb\u03b5\u03c5\u03c4\u03b1\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03bc\u03b1\u03c1\u03b1\u03b8\u03c9\u03bd\u03bf\u03b4\u03c1\u03cc\u03bc\u03bf\u03c5\u03c2 (3-6).<\/p>\n

2. \u0391\u03bb\u03bb\u03b1\u03b3\u03ad\u03c2 \u03c4\u03c9\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03c4\u03c1\u03c9\u03bd <\/b><\/h4>\n

\u0397 \u03c0\u03c4\u03ce\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03a43 \u03ba\u03b1\u03b9 \u03b7 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03bd\u03ac\u03c3\u03c4\u03c1\u03bf\u03c6\u03b7\u03c2 \u03a43 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03bf\u03cd\u03bd \u03c4\u03b9\u03c2 \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b1\u03bb\u03bb\u03b1\u03b3\u03ad\u03c2 \u03c4\u03c9\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03c4\u03c1\u03c9\u03bd \u03b5\u03be\u2019 \u03bf\u03c5 \u03ba\u03b1\u03b9 \u03bf \u03cc\u03c1\u03bf\u03c2 \u00ab\u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf \u03c4\u03b7\u03c2 \u03c7\u03b1\u03bc\u03b7\u03bb\u03ae\u03c2 \u03a43\u00bb. \u038c\u03c3\u03bf \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03b7 \u03b2\u03b1\u03c1\u03cd\u03c4\u03b7\u03c4\u03b1 \u03c4\u03c9\u03bd \u03bd\u03bf\u03c3\u03b7\u03bc\u03ac\u03c4\u03c9\u03bd \u03c4\u03cc\u03c3\u03bf \u03b5\u03c0\u03b9\u03c4\u03b5\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03c0\u03c4\u03ce\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03a43 \u03ba\u03b1\u03b9 \u03b1\u03c1\u03c7\u03af\u03b6\u03bf\u03c5\u03bd \u03bd\u03b1 \u03bc\u03b5\u03b9\u03ce\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03c9\u03bd \u03a44 \u03ba\u03b1\u03b9 TSH \u03c4\u03b1 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c3\u03b5 \u03ae\u03c0\u03b9\u03b1 \u03bd\u03bf\u03c3\u03ae\u03bc\u03b1\u03c4\u03b1 \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03bf\u03c5\u03bd \u03b5\u03bd\u03c4\u03cc\u03c2 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ce\u03bd \u03bf\u03c1\u03af\u03c9\u03bd \u03ba\u03b1\u03b9 \u03af\u03c3\u03c9\u03c2 \u03ba\u03b1\u03b9 \u03bb\u03af\u03b3\u03bf \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b1 (\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 1<\/b>). \u03a4\u03bf 1998 \u03c3\u03b5 \u03b4\u03b7\u03bc\u03bf\u03c3\u03af\u03b5\u03c5\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bf\u03bc\u03ac\u03b4\u03b1\u03c2 \u03c4\u03b7\u03c2 Van den Berghe (7) \u03b4\u03b9\u03b1\u03c4\u03c5\u03c0\u03ce\u03b8\u03b7\u03ba\u03b5 \u03bc\u03b9\u03b1 \u03bd\u03ad\u03b1 \u03b8\u03b5\u03c9\u03c1\u03af\u03b1 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5 \u03c4\u03bf\u03bd \u03c4\u03cd\u03c0\u03bf \u03c4\u03c9\u03bd \u03b1\u03bb\u03bb\u03b1\u03b3\u03ce\u03bd \u03c4\u03c9\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03c4\u03c1\u03c9\u03bd \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03bf \u03b5\u03ac\u03bd \u03b7 \u03bd\u03cc\u03c3\u03bf\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf\u03be\u03b5\u03af\u03b1 \u03ae \u03c0\u03b1\u03c1\u03b1\u03c4\u03b5\u03c4\u03b1\u03bc\u03ad\u03bd\u03b7. \u03a0\u03b9\u03bf \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b1 \u03c3\u03cd\u03bc\u03c6\u03c9\u03bd\u03b1 \u03bc\u03b5 \u03c4\u03bf\u03c5\u03c2 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03ad\u03c2 \u03c5\u03c0\u03bf\u03c3\u03c4\u03b7\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03c4\u03b9\u03c2 \u03c0\u03c1\u03ce\u03c4\u03b5\u03c2 \u03ce\u03c1\u03b5\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b5\u03b3\u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7 \u03ba\u03ac\u03c0\u03bf\u03b9\u03bf\u03c5 \u03b2\u03bb\u03b1\u03c0\u03c4\u03b9\u03ba\u03bf\u03cd \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1 \u03bf\u03b9 \u03bf\u03c1\u03bc\u03cc\u03bd\u03b5\u03c2 \u03c4\u03bf\u03c5 \u03c0\u03c1\u03bf\u03c3\u03b8\u03af\u03bf\u03c5 \u03bb\u03bf\u03b2\u03bf\u03cd \u03c4\u03b7\u03c2 \u03c5\u03c0\u03bf\u03c6\u03cd\u03c3\u03b5\u03c9\u03c2 \u03b4\u03b9\u03b5\u03b3\u03b5\u03af\u03c1\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b5\u03bd\u03ce \u03bf\u03b9 \u03bf\u03c1\u03bc\u03cc\u03bd\u03b5\u03c2 \u03c4\u03c9\u03bd \u03bf\u03c1\u03b3\u03ac\u03bd\u03c9\u03bd \u03c3\u03c4\u03cc\u03c7\u03c9\u03bd \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b4\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03bc\u03b9\u03b1 \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03b1\u03c3\u03b7\u03c2 \u03c3\u03c4\u03b7\u03bd \u03b4\u03c1\u03ac\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c0\u03c1\u03ce\u03c4\u03c9\u03bd. \u0391\u03bd\u03c4\u03af\u03b8\u03b5\u03c4\u03b1, \u03b1\u03bd \u03bf \u03bf\u03c1\u03b3\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c6\u03ad\u03c1\u03b5\u03b9 \u03bd\u03b1 \u03b5\u03c0\u03b9\u03b2\u03b9\u03ce\u03c3\u03b5\u03b9 \u03c4\u03b7\u03c2 \u03bf\u03be\u03b5\u03af\u03b1\u03c2 \u03c6\u03ac\u03c3\u03b7\u03c2 \u03bb\u03cc\u03b3\u03c9 \u03c4\u03b7\u03c2 \u03c0\u03b1\u03c1\u03bf\u03c7\u03ae\u03c2 \u03b5\u03bd\u03c4\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae\u03c2 \u03c6\u03c1\u03bf\u03bd\u03c4\u03af\u03b4\u03b1\u03c2 \u03cc\u03c0\u03c9\u03c2 \u03ba\u03b1\u03c4\u03ac \u03ba\u03cd\u03c1\u03b9\u03bf \u03bb\u03cc\u03b3\u03bf \u03c3\u03c5\u03bc\u03b2\u03b1\u03af\u03bd\u03b5\u03b9 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03bf\u03c5 \u03bd\u03bf\u03c3\u03b7\u03bb\u03b5\u03cd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03bc\u03bf\u03bd\u03ac\u03b4\u03b5\u03c2 \u03b5\u03bd\u03c4\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2, \u03c4\u03cc\u03c4\u03b5 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03bd\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03bf\u03b9 \u03bf\u03c1\u03bc\u03cc\u03bd\u03b5\u03c2 \u03c4\u03b7\u03c2 \u03c5\u03c0\u03bf\u03c6\u03cd\u03c3\u03b5\u03c9\u03c2 \u03ba\u03b1\u03b9 \u03bf\u03b9 \u03bf\u03c1\u03bc\u03cc\u03bd\u03b5\u03c2 \u03c4\u03c9\u03bd \u03bf\u03c1\u03b3\u03ac\u03bd\u03c9\u03bd \u03c3\u03c4\u03cc\u03c7\u03c9\u03bd \u03b4\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7\u03bd \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03c5\u03c0\u03bf\u03c6\u03c5\u03c3\u03b9\u03b1\u03ba\u03ae\u03c2 \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1\u03c2 \u03bc\u03b5 \u03b5\u03be\u03b1\u03af\u03c1\u03b5\u03c3\u03b7 \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03b7\u03c2 \u03ba\u03bf\u03c1\u03c4\u03b9\u03b6\u03cc\u03bb\u03b7\u03c2 \u03c4\u03b1 \u03bf\u03c0\u03bf\u03af\u03b1 \u03b1\u03c5\u03be\u03ac\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9. \u03a0\u03b9\u03b8\u03b1\u03bd\u03ac \u03b7 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03c6\u03ac\u03c3\u03b7 \u03c0\u03c1\u03bf\u03cb\u03c0\u03bf\u03b8\u03ad\u03c4\u03b5\u03b9 \u03ba\u03b1\u03b9 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03b2\u03b1\u03c1\u03cd\u03c4\u03b7\u03c4\u03b1 \u03b1\u03bb\u03bb\u03b9\u03ce\u03c2 \u03bf\u03b9 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03b8\u03b1 \u03b5\u03af\u03c7\u03b1\u03bd \u03b1\u03bd\u03b1\u03bd\u03ae\u03c8\u03b5\u03b9 \u03bc\u03b5\u03c4\u03ac \u03c4\u03b1 \u03c0\u03c1\u03ce\u03c4\u03b1 24\u03c9\u03c1\u03b1, \u03b5\u03c0\u03bf\u03bc\u03ad\u03bd\u03c9\u03c2 \u03bc\u03ac\u03bb\u03bb\u03bf\u03bd \u03c0\u03c1\u03cc\u03ba\u03b5\u03b9\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03b1\u03c5\u03c4\u03cc\u03c3\u03b7\u03bc\u03b5\u03c2 \u03ad\u03bd\u03bd\u03bf\u03b9\u03b5\u03c2. \u0388\u03bd\u03b1 \u03b5\u03c1\u03ce\u03c4\u03b7\u03bc\u03b1 \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03b5\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03cc\u03c3\u03bf \u03b4\u03b9\u03b1\u03c1\u03ba\u03b5\u03af \u03b7 \u03bf\u03be\u03b5\u03af\u03b1 \u03c6\u03ac\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c0\u03cc\u03c4\u03b5 \u03b5\u03b9\u03c3\u03ad\u03c1\u03c7\u03b5\u03c4\u03b1\u03b9 \u03bf \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03c3\u03c4\u03b7 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03c6\u03ac\u03c3\u03b7. \u0394\u03b5\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b5\u03c2 \u03b1\u03bd\u03b1\u03c6\u03bf\u03c1\u03ad\u03c2, \u03cc\u03bc\u03c9\u03c2 \u03b1\u03c0\u03cc \u03cc\u03c4\u03b9 \u03b8\u03b1 \u03b1\u03bd\u03b1\u03c6\u03b5\u03c1\u03b8\u03b5\u03af \u03c3\u03c4\u03b7 \u03c3\u03c5\u03bd\u03ad\u03c7\u03b5\u03b9\u03b1, \u03b7 \u03bf\u03be\u03b5\u03af\u03b1 \u03c6\u03ac\u03c3\u03b7 \u03c0\u03c1\u03bf\u03c3\u03b4\u03b9\u03bf\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b9\u03c2 \u03c0\u03c1\u03ce\u03c4\u03b5\u03c2 \u03ce\u03c1\u03b5\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03ad\u03bd\u03b1\u03c1\u03be\u03b7 \u03c4\u03bf\u03c5 \u03bd\u03bf\u03c3\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2.<\/p>\n

\n

\u00a0\"10.26-figure1\"<\/p>\n

\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 1.<\/strong><\/em> \u039c\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ad\u03c2 \u03c4\u03c9\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03bf\u03c1\u03bc\u03bf\u03bd\u03ce\u03bd \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03b7 \u03b2\u03b1\u03c1\u03cd\u03c4\u03b7\u03c4\u03b1 \u03c4\u03bf\u03c5 \u03bd\u03bf\u03c3\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2 (4).<\/p>\n

\n

\u00a0\u03a4\u03c1\u03b9\u03ca\u03c9\u03b4\u03bf\u03b8\u03c5\u03c1\u03bf\u03bd\u03af\u03bd\u03b7 (\u03a43). <\/b>\u0397 \u03c0\u03c4\u03ce\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03a43 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03c4\u03b7\u03bd \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ae \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ae \u03c4\u03c9\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03c4\u03c1\u03c9\u03bd \u03ba\u03b1\u03b9 \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03cc\u03bb\u03b5\u03c2 \u03c4\u03b9\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c3\u03c4\u03b9\u03c2 \u03bf\u03c0\u03bf\u03af\u03b5\u03c2 \u03ad\u03c7\u03b5\u03b9 \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03b1\u03c6\u03b5\u03af \u03c4\u03bf \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf. \u0397 \u03c0\u03c4\u03ce\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03a43 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03cc\u03c3\u03bf \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03cc\u03c3\u03bf \u03b2\u03b1\u03c1\u03cd\u03c4\u03b5\u03c1\u03bf \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf \u03bd\u03cc\u03c3\u03b7\u03bc\u03b1 (\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 1<\/b>) \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bd\u03bf\u03b4\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c0\u03b1\u03c1\u03ac\u03bb\u03bb\u03b7\u03bb\u03b7 \u03c0\u03c4\u03ce\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03b5\u03bb\u03b5\u03cd\u03b8\u03b5\u03c1\u03b7\u03c2 \u03a43 (FT3) (4) (2).<\/p>\n

\u0398\u03c5\u03c1\u03bf\u03be\u03af\u03bd\u03b7 (\u03a44). <\/b>\u0397 \u03a44 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b2\u03c1\u03b5\u03b8\u03b5\u03af \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03c3\u03b5 \u03b5\u03bb\u03b1\u03c6\u03c1\u03ac \u03bd\u03cc\u03c3\u03bf \u03ae \u03b1\u03ba\u03cc\u03bc\u03b7 \u03ba\u03b1\u03b9 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03c3\u03c4\u03b9\u03c2 \u03c0\u03c1\u03ce\u03c4\u03b5\u03c2 \u03ce\u03c1\u03b5\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03ad\u03bd\u03b1\u03c1\u03be\u03b7 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5. \u038c\u03c4\u03b1\u03bd \u03c4\u03bf \u03bd\u03cc\u03c3\u03b7\u03bc\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03bf\u03b2\u03b1\u03c1\u03cc\u03c4\u03b5\u03c1\u03bf \u03c4\u03cc\u03c4\u03b5 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03c0\u03c4\u03ce\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b5\u03c0\u03b9\u03c0\u03ad\u03b4\u03c9\u03bd \u03c4\u03b7\u03c2 \u03a44 \u03c4\u03bf\u03c5 \u03bf\u03c1\u03bf\u03cd. \u038c\u03c0\u03c9\u03c2 \u03c3\u03c5\u03bc\u03b2\u03b1\u03af\u03bd\u03b5\u03b9 \u03ba\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03a43 \u03bf\u03c1\u03bf\u03cd, \u03cc\u03c3\u03bf \u03b7 \u03b2\u03b1\u03c1\u03cd\u03c4\u03b7\u03c4\u03b1 \u03c4\u03bf\u03c5 \u03bd\u03bf\u03c3\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03cc\u03c3\u03bf \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf\u03b9 \u03c3\u03c5\u03b3\u03ba\u03b5\u03bd\u03c4\u03c1\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c4\u03b7\u03c2 \u03a44 (\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 1<\/b>) (8). \u0395\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd \u03ad\u03c7\u03b5\u03b9 \u03b2\u03c1\u03b5\u03b8\u03b5\u03af \u03cc\u03c4\u03b9 \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03b7\u03c2 \u03a44 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c0\u03c1\u03bf\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u03b1\u03be\u03af\u03b1. \u03a4\u03b9\u03bc\u03ad\u03c2 \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03b1\u03c0\u03cc 4 \u03bcg\/dl \u03c3\u03c5\u03bd\u03bf\u03b4\u03b5\u03cd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03b8\u03bd\u03b7\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1 50%, \u03b5\u03bd\u03ce \u03c4\u03b9\u03bc\u03ad\u03c2 \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03b1\u03c0\u03cc 2 \u03bcg\/dl \u03c3\u03c5\u03bd\u03bf\u03b4\u03b5\u03cd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03b8\u03bd\u03b7\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1 80% (8).<\/p>\n

\u0398\u03c5\u03c1\u03b5\u03bf\u03c4\u03c1\u03cc\u03c0\u03bf\u03c2 \u03bf\u03c1\u03bc\u03cc\u03bd\u03b7 <\/b>TSH<\/b>. <\/b>\u03a3\u03b5 \u03ae\u03c0\u03b9\u03b1 \u03bd\u03cc\u03c3\u03bf \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03b7\u03c2 TSH \u03bf\u03c1\u03bf\u03cd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03bd\u03c4\u03cc\u03c2 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ce\u03bd \u03bf\u03c1\u03af\u03c9\u03bd \u03c0\u03b1\u03c1\u03ac \u03c4\u03b1 \u03c7\u03b1\u03bc\u03b7\u03bb\u03ac \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03b7\u03c2 \u03a43 \u03b5\u03bd\u03ce \u03cc\u03c3\u03bf \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03b7 \u03b2\u03b1\u03c1\u03cd\u03c4\u03b7\u03c4\u03b1 \u03c4\u03bf\u03c5 \u03bd\u03bf\u03c3\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c4\u03cc\u03c3\u03bf \u03b1\u03c1\u03c7\u03af\u03b6\u03bf\u03c5\u03bd \u03ba\u03b1\u03b9 \u03bc\u03b5\u03b9\u03ce\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03b7\u03c2 (\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 2<\/b>). \u03a3\u03b5 \u03c4\u03b1\u03ba\u03c4\u03b9\u03ba\u03ac \u03c7\u03b5\u03b9\u03c1\u03bf\u03c5\u03c1\u03b3\u03b5\u03af\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b7\u03b8\u03b5\u03af \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b5\u03c0\u03b9\u03c0\u03ad\u03b4\u03c9\u03bd \u03c4\u03b7\u03c2 TSH \u03bf\u03c1\u03bf\u03cd \u03c4\u03b9\u03c2 \u03c0\u03c1\u03ce\u03c4\u03b5\u03c2 2-3 \u03ce\u03c1\u03b5\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03c7\u03b5\u03b9\u03c1\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03ae \u03c4\u03bf\u03bc\u03ae (9) \u03c4\u03b1 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c3\u03c4\u03b7\u03bd \u03c3\u03c5\u03bd\u03ad\u03c7\u03b5\u03b9\u03b1 \u03b4\u03b9\u03b1\u03c4\u03b7\u03c1\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b1 \u03c0\u03c1\u03bf\u03b5\u03b3\u03c7\u03b5\u03b9\u03c1\u03b7\u03c4\u03b9\u03ba\u03ac \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03ba\u03b1\u03b9 \u03ba\u03b1\u03c4\u03ac\u03c1\u03b3\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae\u03c2 \u03bc\u03b5\u03c4\u03b1\u03bc\u03b5\u03c3\u03bf\u03bd\u03cd\u03ba\u03c4\u03b9\u03bf\u03c5 \u03b1\u03b9\u03c7\u03bc\u03ae\u03c2 \u03c4\u03b7\u03c2 1 \u03bc\u03b5 5 \u03bc\u03ad\u03c1\u03b5\u03c2 \u03b1\u03c1\u03b3\u03cc\u03c4\u03b5\u03c1\u03b1 (10). \u03a3\u03b5 \u03b2\u03b1\u03c1\u03ad\u03c9\u03c2 \u03c0\u03ac\u03c3\u03c7\u03bf\u03bd\u03c4\u03b5\u03c2 \u03c3\u03b5 \u03bc\u03bf\u03bd\u03ac\u03b4\u03b5\u03c2 \u03b5\u03bd\u03c4\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03bc\u03b5 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b5\u03c4\u03b1\u03bc\u03ad\u03bd\u03b7 \u03bd\u03bf\u03c3\u03b7\u03bb\u03b5\u03af\u03b1, \u03bf\u03b9 \u03bf\u03c0\u03bf\u03af\u03bf\u03b9 \u03b5\u03c0\u03b9\u03b2\u03b9\u03ce\u03bd\u03bf\u03c5\u03bd \u03bb\u03cc\u03b3\u03c9 \u03c4\u03b7\u03c2 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03ba\u03ae\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03b9\u03bc\u03bf\u03b4\u03c5\u03bd\u03b1\u03bc\u03b9\u03ba\u03ae\u03c2 \u03c5\u03c0\u03bf\u03c3\u03c4\u03ae\u03c1\u03b9\u03be\u03b7\u03c2 \u03c0\u03bf\u03c5 \u03c4\u03bf\u03cd\u03c2 \u03c0\u03c1\u03bf\u03c3\u03c6\u03ad\u03c1\u03b5\u03c4\u03b1\u03b9 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c0\u03bf\u03bb\u03cd \u03c7\u03b1\u03bc\u03b7\u03bb\u03ad\u03c2 \u03c4\u03b9\u03bc\u03ad\u03c2 \u03c4\u03b7\u03c2 TSH \u03bf\u03c1\u03bf\u03cd \u03ba\u03b1\u03b8\u03ce\u03c2 \u03ba\u03b1\u03b9 \u03ba\u03b1\u03c4\u03ac\u03c1\u03b3\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03ba\u03b1\u03c4\u03ac \u03ce\u03c3\u03b5\u03b9\u03c2 \u03ad\u03ba\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03cc\u03c0\u03c9\u03c2 \u03c6\u03ac\u03bd\u03b7\u03ba\u03b5 \u03c3\u03b5 \u03b2\u03c1\u03b1\u03b4\u03b9\u03bd\u03ac 9\u03c9\u03c1\u03b1 \u03c0\u03c1\u03bf\u03c6\u03af\u03bb \u03b1\u03bd\u03ac 20 \u03bb\u03b5\u03c0\u03c4\u03ac (11).<\/p>\n

\n

\"10.26-figure2\"<\/p>\n

\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 2.<\/strong><\/em> \u039c\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ad\u03c2 \u03c4\u03c9\u03bd \u03bf\u03c1\u03bc\u03bf\u03bd\u03ce\u03bd \u03c3\u03b5 \u03bf\u03be\u03b5\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b5\u03c4\u03b1\u03bc\u03ad\u03bd\u03b7 \u03bd\u03cc\u03c3\u03bf (7).<\/p>\n

\n

\u0395\u03bb\u03b5\u03cd\u03b8\u03b5\u03c1\u03b1 \u03ba\u03bb\u03ac\u03c3\u03bc\u03b1\u03c4\u03b1 – \u0394\u03b5\u03c3\u03bc\u03b5\u03c5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2 \u03c4\u03c9\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03bf\u03c1\u03bc\u03bf\u03bd\u03ce\u03bd. <\/b>\u039f\u03b9 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ad\u03c2 \u03bf\u03c1\u03bc\u03cc\u03bd\u03b5\u03c2 (\u0398\u039f) \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03bf\u03cd\u03bd \u03c3\u03c4\u03bf\u03bd \u03bf\u03c1\u03cc \u03b5\u03bb\u03b5\u03cd\u03b8\u03b5\u03c1\u03b5\u03c2 \u03ba\u03b1\u03c4\u03ac \u03ad\u03bd\u03b1 \u03c0\u03bf\u03bb\u03cd \u03bc\u03b9\u03ba\u03c1\u03cc \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc, \u03c0\u03bf\u03c5 \u03b5\u03af\u03bd\u03b1\u03b9 0,03 – 0,05% \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03a44 \u03ba\u03b1\u03b9 0,3% \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03a43 (12). \u039f\u03b9 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ad\u03c2 \u03bf\u03c1\u03bc\u03cc\u03bd\u03b5\u03c2 \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03bf\u03cd\u03bd \u03c3\u03c4\u03bf\u03bd \u03bf\u03c1\u03cc \u03c3\u03c5\u03bd\u03b4\u03b5\u03b4\u03b5\u03bc\u03ad\u03bd\u03b5\u03c2 \u03bc\u03b5 \u03b4\u03b5\u03c3\u03bc\u03b5\u03c5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2, \u03bf\u03b9 \u03bf\u03c0\u03bf\u03af\u03b5\u03c2 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf \u03ae\u03c0\u03b1\u03c1 \u03ba\u03b1\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 Thyroxine Binding Globulin (TBG) (\u03b4\u03b5\u03c3\u03bc\u03b5\u03cd\u03b5\u03b9 \u03c4\u03bf 75% \u03c4\u03c9\u03bd \u0398\u039f), \u03b7 \u03c4\u03c1\u03b1\u03bd\u03c3\u03b8\u03c5\u03c1\u03b5\u03c4\u03af\u03bd\u03b7 (TTR) (\u03b4\u03b5\u03c3\u03bc\u03b5\u03cd\u03b5\u03b9 \u03c4\u03bf 10-20% \u03c4\u03c9\u03bd \u0398\u039f) \u03ba\u03b1\u03b9 \u03b7 \u03b1\u03bb\u03b2\u03bf\u03c5\u03bc\u03af\u03bd\u03b7 (\u03b4\u03b5\u03c3\u03bc\u03b5\u03cd\u03b5\u03b9 \u03c4\u03bf 10-20% \u03c4\u03c9\u03bd \u0398\u039f). (13). \u03a3\u03c4\u03b1 \u03b4\u03b9\u03ac\u03c6\u03bf\u03c1\u03b1 \u03bd\u03bf\u03c3\u03ae\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03bd\u03b7\u03c3\u03c4\u03b5\u03af\u03b1 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c4\u03cc\u03c3\u03bf \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ad\u03c2 \u03c4\u03c9\u03bd \u03c3\u03c5\u03b3\u03ba\u03b5\u03bd\u03c4\u03c1\u03ce\u03c3\u03b5\u03c9\u03bd \u03c4\u03c9\u03bd \u03b4\u03b5\u03c3\u03bc\u03b5\u03c5\u03c4\u03b9\u03ba\u03ce\u03bd \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03ce\u03bd \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03b1\u03bb\u03bb\u03b1\u03b3\u03ad\u03c2 \u03c4\u03b7\u03c2 \u03c3\u03c5\u03b3\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03bc\u03b5 \u03c4\u03b9\u03c2 \u0398\u039f (14). \u03a4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03c9\u03bd \u03b4\u03b5\u03c3\u03bc\u03b5\u03c5\u03c4\u03b9\u03ba\u03ce\u03bd \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03ce\u03bd \u03b3\u03b5\u03bd\u03b9\u03ba\u03ac \u03bc\u03b5\u03b9\u03ce\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03c0\u03c1\u03ce\u03c4\u03b5\u03c2 \u03ce\u03c1\u03b5\u03c2 \u03c3\u03c4\u03b7 \u03bd\u03b7\u03c3\u03c4\u03b5\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b1 \u03b4\u03b9\u03ac\u03c6\u03bf\u03c1\u03b1 \u03bd\u03bf\u03c3\u03ae\u03bc\u03b1\u03c4\u03b1 (4) (12), \u03bc\u03b5 \u03b5\u03be\u03b1\u03af\u03c1\u03b5\u03c3\u03b7 \u03c4\u03b7\u03bd \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 TBG \u03c3\u03b5 \u03b7\u03c0\u03b1\u03c4\u03b9\u03ba\u03ac \u03bd\u03bf\u03c3\u03ae\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03bb\u03bf\u03af\u03bc\u03c9\u03be\u03b7 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd \u03b9\u03cc \u03c4\u03bf\u03c5 HIV. \u0395\u03c0\u03af\u03c3\u03b7\u03c2 \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03b7\u03c2 TBG \u03b5\u03c0\u03b1\u03bd\u03ad\u03c1\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c7\u03b5\u03b4\u03cc\u03bd \u03c3\u03c4\u03b1 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b5\u03c4\u03b1\u03bc\u03ad\u03bd\u03b7 \u03bd\u03bf\u03c3\u03b7\u03bb\u03b5\u03af\u03b1 (12). \u0395\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd, \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 \u03cc\u03c0\u03c9\u03c2 \u03b7 \u03c6\u03bf\u03c5\u03c1\u03bf\u03c3\u03b5\u03bc\u03af\u03b4\u03b7 \u03c3\u03b5 \u03c5\u03c8\u03b7\u03bb\u03ad\u03c2 \u03b4\u03cc\u03c3\u03b5\u03b9\u03c2, \u03c4\u03b1 \u03b1\u03bd\u03c4\u03b9\u03b5\u03c0\u03b7\u03bb\u03b9\u03c0\u03c4\u03b9\u03ba\u03ac, \u03c3\u03b1\u03bb\u03b9\u03ba\u03c5\u03bb\u03b9\u03ba\u03ac, \u03b4\u03b9\u03ac\u03c6\u03bf\u03c1\u03bf\u03b9 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03af\u03c4\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03b1\u03b8\u03c1\u03bf\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf \u03c0\u03bb\u03ac\u03c3\u03bc\u03b1 \u03cc\u03c0\u03c9\u03c2 \u03c3\u03c4\u03b7 \u03c3\u03bf\u03b2\u03b1\u03c1\u03ae \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03ba\u03b1\u03b9 \u03b7\u03c0\u03b1\u03c4\u03b9\u03ba\u03ae \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 (4), \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03b5\u03bb\u03b5\u03cd\u03b8\u03b5\u03c1\u03b1 \u03bb\u03b9\u03c0\u03b1\u03c1\u03ac \u03bf\u03be\u03ad\u03b1 (\u03c3\u03b5 \u03c5\u03c8\u03b7\u03bb\u03ad\u03c2 \u03c3\u03c5\u03b3\u03ba\u03b5\u03bd\u03c4\u03c1\u03ce\u03c3\u03b5\u03b9\u03c2 2-5 mmol\/l) \u03b1\u03bd\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03c3\u03cd\u03bd\u03b4\u03b5\u03c3\u03b7 \u03c4\u03c9\u03bd \u0398\u039f \u03bc\u03b5 \u03c4\u03b9\u03c2 \u03b4\u03b5\u03c3\u03bc\u03b5\u03c5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2 (2,14,15). \u0397 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03b7\u03c0\u03b1\u03c1\u03af\u03bd\u03b7\u03c2 \u03cc\u03c0\u03c9\u03c2 \u03c3\u03c5\u03c7\u03bd\u03ac \u03c3\u03c5\u03bc\u03b2\u03b1\u03af\u03bd\u03b5\u03b9 \u03c3\u03b5 \u03bd\u03bf\u03c3\u03b7\u03bb\u03b5\u03c5\u03cc\u03bc\u03b5\u03bd\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03c4\u03b7\u03bd \u03c4\u03c1\u03b9\u03c7\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae \u03bb\u03b9\u03c0\u03bf\u03c0\u03c1\u03c9\u03c4\u03b5\u03b9\u03bd\u03b9\u03ba\u03ae \u03bb\u03b9\u03c0\u03ac\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03b9\u03c2 \u03c3\u03c5\u03b3\u03ba\u03b5\u03bd\u03c4\u03c1\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c4\u03c9\u03bd \u03b5\u03bb\u03b5\u03c5\u03b8\u03b5\u03c1\u03c9\u03bd \u03bb\u03b9\u03c0\u03b1\u03c1\u03c9\u03bd \u03bf\u03be\u03ad\u03c9\u03bd. \u039f\u03b9 \u03b1\u03bb\u03bb\u03b1\u03b3\u03ad\u03c2 \u03b1\u03c5\u03c4\u03ad\u03c2 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c9\u03c2 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03b7\u03bd \u03b4\u03b7\u03bc\u03b9\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03bc\u03b5\u03b8\u03bf\u03b4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ce\u03bd \u03c0\u03c1\u03bf\u03b2\u03bb\u03b7\u03bc\u03ac\u03c4\u03c9\u03bd \u03c3\u03c4\u03b9\u03c2 \u03bc\u03b5\u03c4\u03c1\u03ae\u03c3\u03b5\u03b9\u03c2 \u03c4\u03c9\u03bd \u03b5\u03bb\u03b5\u03c5\u03b8\u03ad\u03c1\u03c9\u03bd \u03ba\u03bb\u03b1\u03c3\u03bc\u03ac\u03c4\u03c9\u03bd \u03c4\u03b7\u03c2 \u03a44 \u03ba\u03b1\u03b9 \u03a43. \u039c\u03ad\u03b8\u03bf\u03b4\u03bf\u03b9 \u03b1\u03bd\u03b1\u03c6\u03bf\u03c1\u03ac\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b9\u03c2 \u03bc\u03b5\u03c4\u03c1\u03ae\u03c3\u03b5\u03b9\u03c2 \u03c4\u03c9\u03bd \u03b5\u03bb\u03b5\u03c5\u03b8\u03ad\u03c1\u03c9\u03bd \u03ba\u03bb\u03b1\u03c3\u03bc\u03ac\u03c4\u03c9\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03bf\u03cd\u03bd \u03b7 \u03b5\u03be\u03b9\u03c3\u03bf\u03c1\u03c1\u03bf\u03c0\u03bf\u03cd\u03bc\u03b5\u03bd\u03b7 \u03b4\u03b9\u03ac\u03bb\u03c5\u03c3\u03b7 (equilibrium dialysis) \u03ba\u03b1\u03b9 \u03b7 \u03c5\u03c0\u03b5\u03c1\u03b4\u03b9\u03ae\u03b8\u03b7\u03c3\u03b7 \u03bf\u03b9 \u03bf\u03c0\u03bf\u03af\u03b5\u03c2 \u03cc\u03bc\u03c9\u03c2 \u03b4\u03b5\u03bd \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03bf\u03cd\u03bd \u03c3\u03c4\u03b7 \u03ba\u03b1\u03b8\u03b7\u03bc\u03b5\u03c1\u03b9\u03bd\u03ae \u03c0\u03c1\u03ac\u03be\u03b7 (4). \u03a4\u03b1 \u03b4\u03b9\u03ac\u03c6\u03bf\u03c1\u03b1 \u03b5\u03bc\u03c0\u03bf\u03c1\u03b9\u03ba\u03ac kit \u03c0\u03bf\u03c5 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c3\u03ae\u03bc\u03b5\u03c1\u03b1 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03be\u03b9\u03cc\u03c0\u03b9\u03c3\u03c4\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b9\u03c2 \u03bc\u03b5\u03c4\u03c1\u03ae\u03c3\u03b5\u03b9\u03c2 \u03c4\u03c9\u03bd \u03b5\u03bb\u03b5\u03c5\u03b8\u03ad\u03c1\u03c9\u03bd \u03ba\u03bb\u03b1\u03c3\u03bc\u03ac\u03c4\u03c9\u03bd \u03c3\u03b5 \u03bd\u03bf\u03c3\u03bf\u03cd\u03bd\u03c4\u03b5\u03c2, \u03ad\u03c4\u03c3\u03b9 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bf \u03af\u03b4\u03b9\u03bf\u03c2 \u03bf\u03c1\u03cc\u03c2 \u03bc\u03b5\u03c4\u03c1\u03bf\u03cd\u03bc\u03b5\u03bd\u03bf\u03c2 \u03bc\u03b5 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03b8\u03cc\u03b4\u03bf\u03c5\u03c2 \u03bd\u03b1 \u03b4\u03ce\u03c3\u03b5\u03b9 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2, \u03c5\u03c8\u03b7\u03bb\u03ad\u03c2 \u03ae \u03c7\u03b1\u03bc\u03b7\u03bb\u03ad\u03c2 \u03c4\u03b9\u03bc\u03ad\u03c2 (2,4) \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c3\u03c5\u03c7\u03bd\u03ac \u03b1\u03bd\u03c4\u03b9\u03ba\u03c1\u03bf\u03c5\u03cc\u03bc\u03b5\u03bd\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03c3\u03c4\u03b7\u03bd \u03b2\u03b9\u03b2\u03bb\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1. \u0395\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03c4\u03b1 \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03ac \u03c7\u03b1\u03bc\u03b7\u03bb\u03ce\u03bd \u03b5\u03bb\u03b5\u03c5\u03b8\u03ad\u03c1\u03c9\u03bd \u03ba\u03bb\u03b1\u03c3\u03bc\u03ac\u03c4\u03c9\u03bd \u03c3\u03b5 \u03b4\u03b9\u03ac\u03c6\u03bf\u03c1\u03b5\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c3\u03c4\u03b9\u03c2 \u03bf\u03c0\u03bf\u03af\u03b5\u03c2 \u03ad\u03c7\u03b5\u03b9 \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03b1\u03c6\u03b5\u03af \u03c4\u03bf \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03b1\u03c4\u03ac \u03c0\u03bf\u03bb\u03cd \u03bc\u03b9\u03ba\u03c1\u03cc\u03c4\u03b5\u03c1\u03b1 \u03b1\u03c5\u03c4\u03ce\u03bd \u03c4\u03c9\u03bd \u03bf\u03bb\u03b9\u03ba\u03ce\u03bd \u03ba\u03bb\u03b1\u03c3\u03bc\u03ac\u03c4\u03c9\u03bd (2,4), \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03bd\u03b1 \u03b1\u03bc\u03c6\u03b9\u03c3\u03b2\u03b7\u03c4\u03b7\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03b4\u03b9\u03b1\u03c6\u03cc\u03c1\u03bf\u03c5\u03c2 \u03bc\u03b5\u03bb\u03b5\u03c4\u03b7\u03c4\u03ad\u03c2 \u03b7 \u03cd\u03c0\u03b1\u03c1\u03be\u03b7 \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b4\u03c1\u03cc\u03bc\u03bf\u03c5 \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c3\u03c4\u03b7\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bf\u03c5\u03c3\u03b9\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03c3\u03b5 \u03b2\u03b9\u03bf\u03c7\u03b7\u03bc\u03b9\u03ba\u03cc \u03bf\u03c1\u03b9\u03c3\u03bc\u03cc.
\n<\/b><\/p>\n

3. \u03a0\u03b1\u03b8\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1<\/b><\/h4>\n

\u0397 \u03c0\u03b1\u03b8\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1 \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b4\u03c1\u03cc\u03bc\u03bf\u03c5 <\/b>\u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03bf\u03bb\u03cd\u03c0\u03bb\u03bf\u03ba\u03b7 \u03b3\u03b9\u03b1\u03c4\u03af \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03b4\u03b9\u03b1\u03c6\u03ad\u03c1\u03b5\u03b9 \u03c3\u03c4\u03b7\u03bd \u03bf\u03be\u03b5\u03af\u03b1 \u03b1\u03c0\u03cc \u03cc\u03c4\u03b9 \u03c3\u03c4\u03b7\u03bd \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03c6\u03ac\u03c3\u03b7 \u03c4\u03c9\u03bd \u03bd\u03bf\u03c3\u03b7\u03bc\u03ac\u03c4\u03c9\u03bd \u03ba\u03b1\u03b8\u03ce\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03c0\u03cc \u03bd\u03cc\u03c3\u03b7\u03bc\u03b1 \u03c3\u03b5 \u03bd\u03cc\u03c3\u03b7\u03bc\u03b1. \u03a4\u03bf \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf \u03cc\u03c0\u03c9\u03c2 \u03ae\u03b4\u03b7 \u03ad\u03c7\u03b5\u03b9 \u03b1\u03bd\u03b1\u03c6\u03b5\u03c1\u03b8\u03b5\u03af, \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b5\u03c4\u03b5\u03c1\u03bf\u03b3\u03b5\u03bd\u03ae \u03bf\u03bc\u03ac\u03b4\u03b1 \u03bd\u03bf\u03c3\u03b7\u03bc\u03ac\u03c4\u03c9\u03bd \u03bc\u03b5 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ae \u03c0\u03b1\u03b8\u03bf\u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03c4\u03bf \u03ba\u03b1\u03b8\u03ad\u03bd\u03b1 \u03ba\u03b1\u03b9 \u03b5\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd \u03c4\u03bf \u03ba\u03ac\u03b8\u03b5 \u03bd\u03cc\u03c3\u03b7\u03bc\u03b1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c3\u03c5\u03bd\u03bf\u03b4\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03bd\u03b7\u03c3\u03c4\u03b5\u03af\u03b1 \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03b1\u03c0\u03cc \u03bc\u03cc\u03bd\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03be\u03b5\u03c7\u03c9\u03c1\u03b9\u03c3\u03c4\u03ae \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b1 \u03c3\u03c5\u03bd\u03b4\u03c1\u03cc\u03bc\u03bf\u03c5 <\/b>\u03c7\u03b1\u03bc\u03b7\u03bb\u03ae\u03c2 \u03a43. <\/b>\u03a6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03c3\u03c4\u03bf \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf \u039c\u0398\u039d \u03b4\u03b5\u03bd \u03c0\u03ac\u03c3\u03c7\u03b5\u03b9 \u03bf \u03ac\u03be\u03bf\u03bd\u03b1\u03c2 \u03a5-\u03a5-\u0398 \u03b1\u03bb\u03bb\u03ac \u03c4\u03c1\u03bf\u03c0\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 o \u03bf\u03c5\u03b4\u03cc\u03c2 \u03c4\u03b7\u03c2 \u03ad\u03ba\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd \u03bf\u03c1\u03bc\u03bf\u03bd\u03ce\u03bd \u03c4\u03bf\u03c5\u03c2, \u03b1\u03bb\u03bb\u03ac\u03b6\u03b5\u03b9 \u03bf \u03c0\u03b5\u03c1\u03b9\u03c6\u03b5\u03c1\u03b9\u03ba\u03cc\u03c2 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03c3\u03bc\u03cc\u03c2 \u03c4\u03c9\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03bf\u03c1\u03bc\u03bf\u03bd\u03ce\u03bd \u03ba\u03b1\u03b8\u03ce\u03c2 \u03ba\u03b1\u03b9 \u03b7 \u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03af\u03b1 \u03c4\u03c9\u03bd \u03b9\u03c3\u03c4\u03ce\u03bd \u03c3\u03b5 \u03b1\u03c5\u03c4\u03ad\u03c2.<\/p>\n

3.1. \u03a5\u03c0\u03bf\u03b8\u03ac\u03bb\u03b1\u03bc\u03bf\u03c2<\/b><\/h5>\n

\u03a3\u03c4\u03b7\u03bd \u03bf\u03be\u03b5\u03af\u03b1 \u03c6\u03ac\u03c3\u03b7 \u03c4\u03c9\u03bd \u03bd\u03bf\u03c3\u03b7\u03bc\u03ac\u03c4\u03c9\u03bd \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03c0\u03c4\u03ce\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03a43 \u03b5\u03bd\u03ce TSH \u03c4\u03bf\u03c5 \u03bf\u03c1\u03bf\u03cd \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03b5\u03b9 \u03b5\u03af\u03c4\u03b5 \u03c3\u03c4\u03b1 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03cc\u03c1\u03b9\u03b1 \u03ae \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03b9\u03ac\u03b6\u03b5\u03b9 \u03c4\u03b1\u03c7\u03b5\u03af\u03b1 \u03c0\u03b1\u03c1\u03bf\u03b4\u03b9\u03ba\u03ae \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b9\u03c2 \u03c0\u03c1\u03ce\u03c4\u03b5\u03c2 \u03ce\u03c1\u03b5\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03ad\u03bd\u03b1\u03c1\u03be\u03b7 \u03c4\u03bf\u03c5 \u03c3\u03c4\u03c1\u03b5\u03c2, \u03cc\u03c0\u03c9\u03c2 \u03ba\u03b1\u03c4\u03b1\u03b3\u03c1\u03ac\u03c6\u03b8\u03b7\u03ba\u03b5 \u03c3\u03b5 \u03c0\u03c1\u03bf\u03b3\u03c1\u03b1\u03bc\u03bc\u03b1\u03c4\u03b9\u03c3\u03bc\u03ad\u03bd\u03b1 \u03c7\u03b5\u03b9\u03c1\u03bf\u03c5\u03c1\u03b3\u03b5\u03af\u03b1 (9). \u0391\u03bd\u03c4\u03af\u03b8\u03b5\u03c4\u03b1 \u03c3\u03c4\u03b7\u03bd \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03c6\u03ac\u03c3\u03b7 \u03ae \u03cc\u03c4\u03b1\u03bd \u03b7 \u03b2\u03b1\u03c1\u03cd\u03c4\u03b7\u03c4\u03b1 \u03c4\u03bf\u03c5 \u03bd\u03bf\u03c3\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2 \u03b5\u03c0\u03b9\u03b4\u03b5\u03b9\u03bd\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c4\u03cc\u03c4\u03b5 \u03b5\u03c0\u03b9\u03c4\u03b5\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03c0\u03c4\u03ce\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03a43 \u03ba\u03b1\u03b9 \u03b5\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd \u03bc\u03b5\u03b9\u03ce\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03b7\u03c2 \u03a44 \u03ba\u03b1\u03b9 TSH. \u0391\u03c5\u03c4\u03ad\u03c2 \u03bf\u03b9 \u03b1\u03bb\u03bb\u03b1\u03b3\u03ad\u03c2 \u03c4\u03b7\u03c2 TSH \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03b1\u03bb\u03bb\u03b1\u03b3\u03ad\u03c2 \u03c4\u03b7\u03c2 \u03ad\u03ba\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 TRH. \u0391\u03c5\u03c4\u03ae \u03b7 \u03ac\u03c0\u03bf\u03c8\u03b7 \u03b5\u03bd\u03b9\u03c3\u03c7\u03cd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c3\u03b5\u03b9\u03c1\u03ac \u03bc\u03b5\u03bb\u03b5\u03c4\u03ce\u03bd \u03c4\u03b7\u03c2 \u03bf\u03bc\u03ac\u03b4\u03b1\u03c2 Van den Berghe \u03c3\u03c4\u03b9\u03c2 \u03bf\u03c0\u03bf\u03af\u03b5\u03c2 \u03b7 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03b5\u03bd\u03b4\u03bf\u03c6\u03bb\u03b5\u03b2\u03af\u03c9\u03c2 TRH \u03b1\u03c0\u03bf\u03ba\u03b1\u03c4\u03ad\u03c3\u03c4\u03b7\u03c3\u03b5 \u03c4\u03bf\u03bd \u03ac\u03be\u03bf\u03bd\u03b1 \u03c5\u03c0\u03bf\u03b8\u03ac\u03bb\u03b1\u03bc\u03bf\u03c2-\u03c5\u03c0\u03cc\u03c6\u03c5\u03c3\u03b7 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03ae\u03c2 \u03ba\u03b1\u03b8\u03ce\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03c0\u03cc \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03bc\u03b5 in-situ \u03c5\u03b2\u03c1\u03b9\u03b4\u03b9\u03c3\u03bc\u03cc \u03c3\u03b5 \u03c5\u03c0\u03bf\u03b8\u03b1\u03bb\u03ac\u03bc\u03bf\u03c5\u03c2 \u03b1\u03c0\u03bf\u03b8\u03b1\u03bd\u03cc\u03bd\u03c4\u03c9\u03bd. \u03a3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b1 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03bf\u03c5 \u03bd\u03bf\u03c3\u03b7\u03bb\u03b5\u03cd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b5\u03c0\u03af \u03bc\u03b1\u03ba\u03c1\u03cc\u03bd \u03c3\u03b5 \u03bc\u03bf\u03bd\u03ac\u03b4\u03b5\u03c2 \u03b5\u03bd\u03c4\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03b7 \u03c3\u03c5\u03bd\u03b5\u03c7\u03ae\u03c2 \u03c3\u03c4\u03ac\u03b3\u03b4\u03b7\u03bd \u03b5\u03bd\u03b4\u03bf\u03c6\u03bb\u03ad\u03b2\u03b9\u03b1 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 TRH \u03b5\u03af\u03c4\u03b5 \u03b3\u03b9\u03b1 9 \u03ce\u03c1\u03b5\u03c2 (16) \u03b5\u03af\u03c4\u03b5 \u03b3\u03b9\u03b1 5 \u03bc\u03ad\u03c1\u03b5\u03c2 (17,18) \u03b1\u03c0\u03bf\u03ba\u03b1\u03c4\u03ad\u03c3\u03c4\u03b7\u03c3\u03b5 \u03c4\u03b7\u03bd \u03b2\u03b1\u03c3\u03b9\u03ba\u03ae \u03ad\u03ba\u03ba\u03c1\u03b9\u03c3\u03b7 \u03c4\u03b7\u03c2 TSH \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03c9\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03bf\u03c1\u03bc\u03bf\u03bd\u03ce\u03bd (\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 4<\/b>). \u03a3\u03c4\u03b9\u03c2 \u03af\u03b4\u03b9\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03b7 \u03b5\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 GHRP-2 \u03b2\u03b5\u03bb\u03c4\u03af\u03c9\u03c3\u03b5 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03ba\u03b1\u03c4\u03ac \u03ce\u03c3\u03b5\u03b9\u03c2 \u03ad\u03ba\u03ba\u03c1\u03b9\u03c3\u03b7 \u03c4\u03b7\u03c2 TSH. \u0391\u03bd\u03bf\u03c3\u03bf\u03ca\u03c3\u03c4\u03bf\u03c7\u03b7\u03bc\u03b5\u03af\u03b1 \u03c4\u03bf\u03c5 \u03c5\u03c0\u03bf\u03b8\u03b1\u03bb\u03ac\u03bc\u03bf\u03c5 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03c9\u03bd \u03c3\u03b5 \u03bd\u03b5\u03ba\u03c1\u03bf\u03c4\u03bf\u03bc\u03b9\u03ba\u03cc \u03c5\u03bb\u03b9\u03ba\u03cc \u03ad\u03b4\u03b5\u03b9\u03be\u03b5 \u03cc\u03c4\u03b9 \u03c3\u03b5 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03c0\u03bf\u03c5 \u03c0\u03b5\u03b8\u03b1\u03af\u03bd\u03bf\u03c5\u03bd \u03b1\u03b9\u03c6\u03bd\u03af\u03b4\u03b9\u03b1 \u03b7 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 TRH \u03b4\u03b5\u03bd \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b1\u03bd\u03c4\u03af\u03b8\u03b5\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03bc\u03b5\u03b3\u03ac\u03bb\u03b7 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03bc\u03b5 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b5\u03c4\u03b1\u03bc\u03ad\u03bd\u03b7 \u03bd\u03bf\u03c3\u03b7\u03bb\u03b5\u03af\u03b1 (\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 3<\/b>) (19). \u03a3\u03c4\u03b7\u03bd \u03af\u03b4\u03b9\u03b1 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03b5\u03bb\u03ae\u03c6\u03b8\u03b7\u03c3\u03b1\u03bd \u03b1\u03b9\u03bc\u03bf\u03bb\u03b7\u03c8\u03af\u03b5\u03c2 24 \u03ce\u03c1\u03b5\u03c2 \u03c0\u03c1\u03b9\u03bd \u03c4\u03bf\u03bd \u03b8\u03ac\u03bd\u03b1\u03c4\u03bf \u03c4\u03c9\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03c0\u03c1\u03bf\u03c3\u03b4\u03b9\u03bf\u03c1\u03b9\u03c3\u03bc\u03cc \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03bf\u03c1\u03bc\u03bf\u03bd\u03ce\u03bd \u03c4\u03bf\u03c5 \u03bf\u03c1\u03bf\u03cd \u03ba\u03b1\u03b9 \u03c5\u03c0\u03ae\u03c1\u03be\u03b5 \u03b8\u03b5\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03c3\u03c7\u03ad\u03c4\u03b9\u03c3\u03b7 \u03c4\u03bf\u03c5 TRH-mRNA \u03bc\u03b5 \u03c4\u03b7\u03bd T3 \u03ba\u03b1\u03b9 \u03bc\u03b5 log-TSH \u03bf\u03c1\u03bf\u03cd.<\/p>\n

\n

\u00a0\"10.26-figure3\"<\/p>\n

\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 3.<\/strong><\/em> \u0391\u03bd\u03bf\u03c3\u03bf\u03ca\u03c3\u03c4\u03bf\u03c7\u03b7\u03bc\u03b5\u03af\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03bf \u03a4RH \u03c3\u03c4\u03bf\u03bd \u03c5\u03c0\u03bf\u03b8\u03ac\u03bb\u03b1\u03bc\u03bf \u03c3\u03b5 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03b9\u03bd\u03bf \u03bd\u03b5\u03ba\u03c1\u03bf\u03c4\u03bf\u03bc\u03b9\u03ba\u03cc \u03c5\u03bb\u03b9\u03ba\u03cc. \u0391: \u03a5\u03c0\u03bf\u03b8\u03ac\u03bb\u03b1\u03bc\u03bf\u03c2 \u03c3\u03b5 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03bc\u03b5 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b5\u03c4\u03b1\u03bc\u03ad\u03bd\u03b7 \u03bd\u03bf\u03c3\u03b7\u03bb\u03b5\u03af\u03b1 \u0392: \u03a5\u03c0\u03bf\u03b8\u03ac\u03bb\u03b1\u03bc\u03bf\u03c2 \u03c3\u03b5 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03bc\u03b5 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03ba\u03ae \u03b1\u03bd\u03b1\u03ba\u03bf\u03c0\u03ae (19).<\/p>\n

\n

\"10.26-figure4\"<\/p>\n

\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 4.<\/b><\/em> \u0391\u03bd\u03c4\u03b9\u03c0\u03c1\u03bf\u03c3\u03c9\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03cc 24\u03c9\u03c1\u03bf \u03c0\u03c1\u03bf\u03c6\u03af\u03bb \u03ad\u03ba\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2 TSH \u03c3\u03b5 \u03b2\u03b1\u03c1\u03ad\u03c9\u03c2 \u03c0\u03ac\u03c3\u03c7\u03bf\u03bd\u03c4\u03b1 \u03c0\u03c1\u03b9\u03bd \u03ba\u03b1\u03b9 \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7\u03bd \u03b5\u03bd\u03b4\u03bf\u03c6\u03bb\u03ad\u03b2\u03b9\u03bf \u03c3\u03c4\u03ac\u03b3\u03b4\u03b7\u03bd \u03ad\u03b3\u03c7\u03c5\u03c3\u03b7 TRH (1 \u03bcg\/kg bolus \u03c3\u03c4\u03b9\u03c2 09:00, \u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03bf\u03cd\u03bc\u03b5\u03bd\u03bf \u03b1\u03c0\u03cc 1 \u03bcg\/kg\/h \u03c3\u03c5\u03bd\u03b5\u03c7\u03bf\u03cd\u03c2 \u03ad\u03b3\u03c7\u03c5\u03c3\u03b7\u03c2 \u03ad\u03c9\u03c2 \u03c4\u03b9\u03c2 06:00) (16).<\/p>\n

\n

\u00a0\u0397 \u03c1\u03cd\u03b8\u03bc\u03b9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03ad\u03ba\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03cd\u03bd\u03b8\u03b5\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 TRH \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5\u03c2 \u03c5\u03c0\u03bf\u03c6\u03c5\u03c3\u03b9\u03bf\u03c4\u03c1\u03cc\u03c0\u03bf\u03c5\u03c2 \u03c5\u03c0\u03bf\u03b8\u03b1\u03bb\u03b1\u03bc\u03b9\u03ba\u03bf\u03cd\u03c2 \u03bd\u03b5\u03c5\u03c1\u03ce\u03bd\u03b5\u03c2 \u03c5\u03c0\u03cc\u03ba\u03b5\u03b9\u03c4\u03b1\u03b9 \u03b1\u03c6\u03b5\u03bd\u03cc\u03c2 \u03c3\u03c4\u03b7\u03bd \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae \u03c0\u03b1\u03bb\u03af\u03bd\u03b4\u03c1\u03bf\u03bc\u03b7 \u03b4\u03c1\u03ac\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b4\u03b9\u03ba\u03ce\u03bd \u03bf\u03c1\u03bc\u03bf\u03bd\u03ce\u03bd \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03ac\u03bb\u03bb\u03b1 \u03b5\u03c5\u03bf\u03b4\u03c9\u03c4\u03b9\u03ba\u03ac \u03ae \u03b1\u03bd\u03b1\u03c3\u03c4\u03b1\u03bb\u03c4\u03b9\u03ba\u03ac \u03c3\u03ae\u03bc\u03b1\u03c4\u03b1 \u03c0\u03bf\u03c5 \u03b4\u03ad\u03c7\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03ac\u03bb\u03bb\u03bf\u03c5\u03c2 \u03bd\u03b5\u03c5\u03c1\u03ce\u03bd\u03b5\u03c2 \u03c4\u03bf\u03c5 \u03b5\u03b3\u03ba\u03b5\u03c6\u03ac\u03bb\u03bf\u03c5 (\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 5<\/b>) (20). \u0388\u03c4\u03c3\u03b9 \u03bb\u03bf\u03b9\u03c0\u03cc\u03bd \u03bf\u03b9 \u03bd\u03b5\u03c5\u03c1\u03ce\u03bd\u03b5\u03c2 \u03b1\u03c5\u03c4\u03bf\u03af \u03b4\u03ad\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c0\u03bb\u03b7\u03b8\u03ce\u03c1\u03b1 \u03bc\u03b7\u03bd\u03c5\u03bc\u03ac\u03c4\u03c9\u03bd \u03ba\u03b1\u03b9 \u03b7 \u03c4\u03b5\u03bb\u03b9\u03ba\u03ae \u03b1\u03c0\u03ac\u03bd\u03c4\u03b7\u03c3\u03b7 \u03b4\u03b7\u03bb\u03b1\u03b4\u03ae \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03ae \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 TRH \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03c3\u03c5\u03bd\u03b9\u03c3\u03c4\u03b1\u03bc\u03ad\u03bd\u03b7 \u03cc\u03bb\u03c9\u03bd \u03b1\u03c5\u03c4\u03ce\u03bd \u03c4\u03c9\u03bd \u03b4\u03c1\u03ac\u03c3\u03b5\u03c9\u03bd. \u039f\u03b9 \u03b5\u03bd\u03b4\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03b9\u03bf\u03b9 \u03bc\u03b5\u03c4\u03b1\u03b3\u03c1\u03b1\u03c6\u03b9\u03ba\u03bf\u03af \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03ba\u03b1\u03b8\u03bf\u03c1\u03af\u03b6\u03bf\u03c5\u03bd \u03b1\u03c5\u03c4\u03ae\u03bd \u03c4\u03b7\u03bd \u03b1\u03c0\u03ac\u03bd\u03c4\u03b7\u03c3\u03b7, \u03b1\u03bd\u03ac\u03bc\u03b5\u03c3\u03b1 \u03c3\u03b5 \u03ac\u03bb\u03bb\u03bf\u03c5\u03c2, \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf \u03c6\u03c9\u03c3\u03c6\u03bf\u03c1\u03c5\u03bb\u03b9\u03c9\u03bc\u03ad\u03bd\u03bf\u03c2 CREB \u03ba\u03b1\u03b9 \u03b7 T3 (20).<\/p>\n

\n

\"10.26-figure5\"
\n<\/b><\/p>\n

\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 5.<\/b> \u03a1\u03cd\u03b8\u03bc\u03b9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03ad\u03ba\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2 TRH \u03c3\u03c4\u03bf\u03c5\u03c2 \u03c5\u03c0\u03bf\u03c6\u03c5\u03c3\u03b9\u03bf\u03c4\u03c1\u03cc\u03c0\u03bf\u03c5\u03c2 TRH \u03bd\u03b5\u03c5\u03c1\u03ce\u03bd\u03b5\u03c2 \u03c4\u03bf\u03c5 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03b9\u03bb\u03b9\u03b1\u03ba\u03bf\u03cd \u03c0\u03c5\u03c1\u03ae\u03bd\u03b1 \u03c4\u03bf\u03c5 \u03b5\u03b3\u03ba\u03b5\u03c6\u03ac\u03bb\u03bf\u03c5.<\/p>\n

\n

\u0397 \u03bd\u03b7\u03c3\u03c4\u03b5\u03af\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03cc \u03c0\u03b1\u03c1\u03ac\u03b4\u03b5\u03b9\u03b3\u03bc\u03b1 \u03c3\u03c5\u03bd\u03b4\u03c1\u03cc\u03bc\u03bf\u03c5 \u039c\u0398\u039d \u03c3\u03c4\u03bf \u03bf\u03c0\u03bf\u03af\u03bf \u03ad\u03c7\u03b5\u03b9 \u03bc\u03b5\u03bb\u03b5\u03c4\u03b7\u03b8\u03b5\u03af \u03bb\u03b5\u03c0\u03c4\u03bf\u03bc\u03b5\u03c1\u03ce\u03c2 \u03bf \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2 \u03c0\u03c4\u03ce\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 TRH \u03c3\u03b5 \u03c0\u03b5\u03b9\u03c1\u03b1\u03bc\u03b1\u03c4\u03cc\u03b6\u03c9\u03b1. \u039a\u03b1\u03c4\u03ac \u03c4\u03b7\u03bd \u03bd\u03b7\u03c3\u03c4\u03b5\u03af\u03b1 \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03b7\u03c2 \u03bb\u03b5\u03c0\u03c4\u03af\u03bd\u03b7\u03c2 \u03bc\u03b5\u03b9\u03ce\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc\u03c4\u03bf\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03b1\u03bd\u03b5\u03be\u03ac\u03c1\u03c4\u03b7\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03b1\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1\u03c2 \u03bb\u03af\u03c0\u03bf\u03c5\u03c2 (21,22). \u03a3\u03b5 \u03c0\u03b5\u03b9\u03c1\u03b1\u03bc\u03b1\u03c4\u03cc\u03b6\u03c9\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03b4\u03b5\u03b9\u03c7\u03b8\u03b5\u03af \u03cc\u03c4\u03b9, \u03b7 \u03c0\u03c4\u03ce\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bb\u03b5\u03c0\u03c4\u03af\u03bd\u03b7\u03c2 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af \u03b1\u03bb\u03bb\u03b1\u03b3\u03ad\u03c2 \u03c3\u03c4\u03b7\u03bd \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03ad\u03ba\u03ba\u03c1\u03b9\u03c3\u03b7 \u03b4\u03b9\u03b1\u03c6\u03cc\u03c1\u03c9\u03bd \u03c0\u03b5\u03c0\u03c4\u03b9\u03b4\u03af\u03c9\u03bd \u03c3\u03c4\u03bf\u03c5\u03c2 \u03bd\u03b5\u03c5\u03c1\u03ce\u03bd\u03b5\u03c2 \u03c4\u03bf\u03c5 \u03c4\u03bf\u03be\u03bf\u03b5\u03b9\u03b4\u03ae \u03c0\u03c5\u03c1\u03ae\u03bd\u03b1 \u03c4\u03bf\u03c5 \u03c5\u03c0\u03bf\u03b8\u03b1\u03bb\u03ac\u03bc\u03bf\u03c5 \u03bf\u03b9 \u03bf\u03c0\u03bf\u03af\u03bf\u03b9 \u03bc\u03b5 \u03c4\u03b7 \u03c3\u03b5\u03b9\u03c1\u03ac \u03c4\u03bf\u03c5\u03c2 \u03bd\u03b5\u03c5\u03c1\u03ce\u03bd\u03bf\u03c5\u03bd \u03c4\u03bf\u03c5\u03c2 \u03c5\u03c0\u03bf\u03c6\u03c5\u03c3\u03b9\u03bf\u03c4\u03c1\u03cc\u03c0\u03bf\u03c5\u03c2 \u03bd\u03b5\u03c5\u03c1\u03ce\u03bd\u03b5\u03c2 TRH \u03c4\u03bf\u03c5 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03b9\u03bb\u03b9\u03b1\u03ba\u03bf\u03cd \u03c0\u03c5\u03c1\u03ae\u03bd\u03b1. \u03a3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b5\u03c0\u03b9\u03c0\u03ad\u03b4\u03c9\u03bd \u03c4\u03c9\u03bd NPY (\u03bd\u03b5\u03c5\u03c1\u03bf\u03c0\u03b5\u03c0\u03c4\u03b9\u03b4\u03b9\u03bf \u03a5) \u03ba\u03b1\u03b9 AGRP (Agouti-related protein) \u03ba\u03b1\u03b9 \u03c4\u03b1\u03c5\u03c4\u03cc\u03c7\u03c1\u03bf\u03bd\u03b7 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b1-MSH (\u03b1-melanocyte stimulating hormone) \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03bd\u03b1 \u03bc\u03b5\u03b9\u03ce\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 TRH \u03c5\u03c0\u03b5\u03c1\u03b9\u03c3\u03c7\u03cd\u03bf\u03c5\u03c3\u03b1\u03c2 \u03c4\u03b7\u03c2 \u03b5\u03c5\u03bf\u03b4\u03c9\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b4\u03c1\u03ac\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd \u03bc\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03c9\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03bf\u03c1\u03bc\u03bf\u03bd\u03ce\u03bd (\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 6<\/b>) (4,20). \u039d\u03b7\u03c3\u03c4\u03b5\u03af\u03b1 72 \u03c9\u03c1\u03ce\u03bd \u03c3\u03b5 \u03bd\u03bf\u03c1\u03bc\u03bf\u03b2\u03b1\u03c1\u03b5\u03af\u03c2 \u03ac\u03bd\u03b4\u03c1\u03b5\u03c2 \u03ad\u03c7\u03b5\u03b9 \u03c9\u03c2 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03b7\u03bd \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03ba\u03b1\u03c4\u03ac \u03ba\u03cd\u03c1\u03b9\u03bf \u03bb\u03cc\u03b3\u03bf \u03c4\u03b7\u03c2 \u03ba\u03b1\u03c4\u03ac \u03ce\u03c3\u03b5\u03b9\u03c2 \u03ad\u03ba\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 TSH \u03ba\u03b1\u03b8\u03ce\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03c4\u03ce\u03c3\u03b7 \u03ba\u03b1\u03c4\u03ac 30% \u03c4\u03b7\u03c2 \u03a43, \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03bd\u03ac\u03c3\u03c4\u03c1\u03bf\u03c6\u03b7\u03c2 \u03a43, \u03c7\u03c9\u03c1\u03af\u03c2 \u03b1\u03bb\u03bb\u03b1\u03b3\u03ad\u03c2 \u03c3\u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03b7\u03c2 \u03a44 \u03ba\u03b1\u03b9 TBG (21). \u03a3\u03c4\u03b7\u03bd \u03af\u03b4\u03b9\u03b1 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03b7 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c1\u03af\u03c9\u03c2 \u03b1\u03bd\u03b1\u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03ad\u03bd\u03b7\u03c2 \u03bb\u03b5\u03c0\u03c4\u03af\u03bd\u03b7\u03c2 \u03b3\u03b9\u03b1 3 \u03b7\u03bc\u03ad\u03c1\u03b5\u03c2 \u03b1\u03c0\u03bf\u03ba\u03b1\u03c4\u03ad\u03c3\u03c4\u03b7\u03c3\u03b5 \u03c4\u03bf \u03c0\u03c1\u03bf\u03c6\u03af\u03bb \u03ad\u03ba\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 TSH \u03c7\u03c9\u03c1\u03af\u03c2 \u03cc\u03bc\u03c9\u03c2 \u03bd\u03b1 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03c3\u03b5\u03b9 \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03c9\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03bf\u03c1\u03bc\u03bf\u03bd\u03ce\u03bd. \u03a0\u03c1\u03bf\u03ba\u03b5\u03b9\u03bc\u03ad\u03bd\u03bf\u03c5 \u03bd\u03b1 \u03b4\u03b9\u03b1\u03c0\u03b9\u03c3\u03c4\u03c9\u03b8\u03b5\u03af \u03b5\u03ac\u03bd \u03b7 \u03b4\u03c1\u03ac\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bb\u03b5\u03c0\u03c4\u03af\u03bd\u03b7\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c4\u03bf \u03c5\u03c0\u03bf\u03b8\u03ac\u03bb\u03b1\u03bc\u03bf \u03ae \u03c3\u03c4\u03b7\u03bd \u03c5\u03c0\u03cc\u03c6\u03c5\u03c3\u03b7 \u03ad\u03b3\u03b9\u03bd\u03b5 TRH \u03c4\u03b5\u03c3\u03c4 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03bd\u03b7\u03c3\u03c4\u03b5\u03cd\u03bf\u03bd\u03c4\u03b5\u03c2 \u03bc\u03b5 \u03b7 \u03c7\u03c9\u03c1\u03af\u03c2 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03bb\u03b5\u03c0\u03c4\u03af\u03bd\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03b4\u03b5\u03bd \u03b2\u03c1\u03b5\u03b8\u03b7\u03ba\u03b1\u03bd \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03ad\u03c2.<\/p>\n

\n

\"10.26-figure6\"<\/p>\n

\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 6.<\/strong><\/em> \u039c\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2 \u03c0\u03c4\u03ce\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 TRH \u03c3\u03b5 \u03bd\u03b7\u03c3\u03c4\u03b5\u03af\u03b1.<\/p>\n

\n

\u0395\u03c0\u03af\u03c3\u03b7\u03c2 \u03c3\u03b5 \u03c0\u03b5\u03b9\u03c1\u03b1\u03bc\u03b1\u03c4\u03cc\u03b6\u03c9\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03bc\u03b5\u03bb\u03b5\u03c4\u03b7\u03b8\u03b5\u03af \u03bf \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2 \u03c4\u03bf\u03c5 \u03ba\u03b5\u03bd\u03c4\u03c1\u03b9\u03ba\u03bf\u03cd \u03c5\u03c0\u03bf\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03c3\u03bc\u03bf\u03cd \u03c3\u03c4\u03b7\u03bd \u03c3\u03ae\u03c8\u03b7. \u0397 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03bb\u03b9\u03c0\u03bf\u03c0\u03bf\u03bb\u03c5\u03c3\u03b1\u03ba\u03c7\u03b1\u03c1\u03af\u03b4\u03b7\u03c2 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c4\u03b7\u03c2 \u03c5\u03c0\u03bf\u03b8\u03b1\u03bb\u03b1\u03bc\u03b9\u03ba\u03ae\u03c2 D2 \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03bf\u03c0\u03b9\u03ba\u03cc \u03a43 \u03c5\u03c0\u03b5\u03c1\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03c3\u03bc\u03cc \u03ba\u03b1\u03b9 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2 \u03c4\u03b7\u03c2 \u03c3\u03cd\u03bd\u03b8\u03b5\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 TRH (\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 7<\/b>) (4, 20, 23).<\/p>\n

\n

\u00a0\"10.26-figure7\"<\/p>\n

\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 7.<\/strong><\/em> \u039c\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2 \u03c0\u03c4\u03ce\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 TRH \u03c3\u03c4\u03b7 \u03c3\u03ae\u03c8\u03b7 (4).<\/p>\n

\n

\n

\u00a03.2. \u03a0\u03b5\u03c1\u03b9\u03c6\u03b5\u03c1\u03b9\u03ba\u03cc\u03c2 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03c3\u03bc\u03cc\u03c2 \u03c4\u03c9\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03bf\u03c1\u03bc\u03bf\u03bd\u03ce\u03bd – \u0391\u03c0\u03bf\u03ca\u03c9\u03b4\u03b9\u03bd\u03ac\u03c3\u03b5\u03c2.<\/b><\/h5>\n

\u0397 \u03b8\u03c5\u03c1\u03bf\u03be\u03af\u03bd\u03b7 \u03c4\u03bf\u03c5 \u03bf\u03c1\u03bf\u03cd \u03c0\u03c1\u03bf\u03ad\u03c1\u03c7\u03b5\u03c4\u03b1\u03b9 \u03b5\u03be\u03bf\u03bb\u03bf\u03ba\u03bb\u03ae\u03c1\u03bf\u03c5 \u03b1\u03c0\u03cc \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae \u03ad\u03ba\u03ba\u03c1\u03b9\u03c3\u03b7 \u03b5\u03bd\u03ce \u03b1\u03bd\u03c4\u03af\u03b8\u03b5\u03c4\u03b1 \u03b7 \u03a43 \u03c4\u03bf\u03c5 \u03bf\u03c1\u03bf\u03cd \u03c0\u03c1\u03bf\u03ad\u03c1\u03c7\u03b5\u03c4\u03b1\u03b9 \u03ba\u03b1\u03c4\u03ac 15-20% \u03b1\u03c0\u03cc \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae \u03ad\u03ba\u03ba\u03c1\u03b9\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03ba\u03b1\u03c4\u03ac \u03c4\u03bf \u03c5\u03c0\u03cc\u03bb\u03bf\u03b9\u03c0\u03bf \u03b1\u03c0\u03cc \u03c0\u03b5\u03c1\u03b9\u03c6\u03b5\u03c1\u03b9\u03ba\u03ae \u03b1\u03c0\u03bf\u03ca\u03c9\u03b4\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03a44 \u03bc\u03b5\u03c3\u03c9 \u03c4\u03c9\u03bd \u03b1\u03c0\u03bf\u03ca\u03c9\u03b4\u03b9\u03bd\u03b1\u03c3\u03ce\u03bd (24). \u0391\u03be\u03af\u03b6\u03b5\u03b9 \u03bd\u03b1 \u03c3\u03b7\u03bc\u03b5\u03b9\u03c9\u03b8\u03b5\u03af \u03cc\u03c4\u03b9 \u03c3\u03c4\u03b1 \u03c4\u03c1\u03c9\u03ba\u03c4\u03b9\u03ba\u03ac \u03b7 \u03a43 \u03c0\u03c1\u03bf\u03ad\u03c1\u03c7\u03b5\u03c4\u03b1\u03b9 \u03ba\u03b1\u03c4\u03ac 50% \u03b1\u03c0\u03cc \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae \u03ad\u03ba\u03ba\u03c1\u03b9\u03c3\u03b7 (25). \u039f\u03b9 \u03b1\u03c0\u03bf\u03ca\u03c9\u03b4\u03b9\u03bd\u03ac\u03c3\u03b5\u03c2 (D1,D2,D3) \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03bf\u03bc\u03ac\u03b4\u03b1 3 \u03b9\u03c3\u03bf\u03b5\u03bd\u03b6\u03cd\u03bc\u03c9\u03bd \u03c0\u03bf\u03c5 \u03ba\u03c9\u03b4\u03b9\u03ba\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ac \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 \u03b5\u03ba\u03c6\u03c1\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03b9\u03c3\u03c4\u03bf\u03cd\u03c2 \u03ba\u03b1\u03b9 \u03bf\u03b9 \u03bf\u03c0\u03bf\u03af\u03b5\u03c2 \u03b1\u03c0\u03bf\u03bc\u03b1\u03ba\u03c1\u03cd\u03bd\u03bf\u03c5\u03bd \u03ad\u03bd\u03b1 \u03ac\u03c4\u03bf\u03bc\u03bf \u03b9\u03c9\u03b4\u03af\u03bf\u03c5 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd \u03b5\u03be\u03c9\u03c4\u03b5\u03c1\u03b9\u03ba\u03cc \u03ae \u03b5\u03c3\u03c9\u03c4\u03b5\u03c1\u03b9\u03ba\u03cc \u03b4\u03b1\u03ba\u03c4\u03cd\u03bb\u03b9\u03bf \u03c4\u03b7\u03c2 \u03a44. \u039f\u03b9 \u03b1\u03c0\u03bf\u03ca\u03c9\u03b4\u03b9\u03bd\u03ac\u03c3\u03b5\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf\u03be\u03b5\u03b9\u03b4\u03bf\u03b1\u03bd\u03b1\u03b3\u03c9\u03b3\u03ac\u03c3\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03b4\u03b9\u03b1\u03c6\u03ad\u03c1\u03bf\u03c5\u03bd \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03c4\u03bf\u03c5\u03c2 \u03c9\u03c2 \u03c0\u03c1\u03bf\u03c2 \u03c4\u03b9\u03c2 \u03ba\u03b9\u03bd\u03b7\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03b9\u03b4\u03b9\u03cc\u03c4\u03b7\u03c4\u03b5\u03c2, \u03c4\u03b7\u03bd \u03c3\u03c5\u03b3\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1 \u03bc\u03b5 \u03c4\u03b1 \u03c5\u03c0\u03bf\u03c3\u03c4\u03c1\u03ce\u03bc\u03b1\u03c4\u03b1, \u03c4\u03b7\u03bd \u03b9\u03c3\u03c4\u03b9\u03ba\u03ae \u03ba\u03b1\u03c4\u03b1\u03bd\u03bf\u03bc\u03ae, \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03b7 \u03c4\u03bf\u03c5\u03c2 \u03c3\u03b5 \u03c5\u03c0\u03b5\u03c1 \u03ae \u03c5\u03c0\u03bf\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03c3\u03bc\u03cc (\u03a0\u03af\u03bd\u03b1\u03ba\u03b1\u03c2 1<\/b>). \u0397 \u03b1\u03c0\u03bf\u03ca\u03c9\u03b4\u03b9\u03bd\u03ac\u03c3\u03b7 D1 \u03ba\u03b1\u03c4\u03b1\u03bb\u03cd\u03b5\u03b9 \u03ba\u03b1\u03b9 \u03c4\u03b9\u03c2 2 \u03b1\u03bd\u03c4\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03b4\u03b7\u03bb\u03b1\u03b4\u03ae \u03b1\u03c0\u03bf\u03ca\u03c9\u03b4\u03b9\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03a44 \u03c0\u03c1\u03bf\u03c2 \u03a43 (5\u2019 \u03b1\u03bd\u03c4\u03af\u03b4\u03c1\u03b1\u03c3\u03b7) \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03c2 rT3 (5 \u03b1\u03bd\u03c4\u03af\u03b4\u03c1\u03b1\u03c3\u03b7) (4). \u039f\u03b9 \u03b1\u03c0\u03bf\u03ca\u03c9\u03b4\u03b9\u03bd\u03ac\u03c3\u03b5\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b5\u03bc\u03b2\u03c1\u03b1\u03bd\u03b9\u03ba\u03ad\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2 \u03bc\u03b5 \u03c4\u03bf \u03b5\u03bd\u03b5\u03c1\u03b3\u03cc \u03c4\u03bc\u03ae\u03bc\u03b1 \u03c0\u03c1\u03bf\u03c2 \u03c4\u03bf \u03ba\u03c5\u03c4\u03b1\u03c1\u03bf\u03c0\u03bb\u03b1\u03c3\u03bc\u03b1. \u039f\u03b9 D1 \u03ba\u03b1\u03b9 D3 \u03b2\u03c1\u03af\u03c3\u03ba\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03ba\u03c5\u03c4\u03b1\u03c1\u03bf\u03c0\u03bb\u03b1\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03bc\u03b5\u03bc\u03b2\u03c1\u03ac\u03c3\u03b7 \u03bf\u03c0\u03cc\u03c4\u03b5 \u03c4\u03bf \u03c0\u03c1\u03bf\u03ca\u03cc\u03bd \u03c4\u03bf\u03c5\u03c2 \u03b5\u03c5\u03ba\u03bf\u03bb\u03cc\u03c4\u03b5\u03c1\u03b1 \u03bc\u03b5\u03c4\u03b1\u03c6\u03ad\u03c1\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf \u03c0\u03bb\u03ac\u03c3\u03bc\u03b1 \u03b5\u03bd\u03ce \u03b7 D2 \u03c3\u03c4\u03b7\u03bd \u03bc\u03b5\u03bc\u03b2\u03c1\u03ac\u03bd\u03b7 \u03c4\u03bf\u03c5 \u03b5\u03bd\u03b4\u03bf\u03c0\u03bb\u03b1\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03bf\u03cd \u03b4\u03b9\u03ba\u03c4\u03cd\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03c4\u03bf \u03c0\u03c1\u03bf\u03ca\u03cc\u03bd \u03c4\u03b7\u03c2 \u03bc\u03b5\u03c4\u03b1\u03c6\u03ad\u03c1\u03b5\u03c4\u03b1\u03b9 \u03b5\u03c5\u03ba\u03bf\u03bb\u03cc\u03c4\u03b5\u03c1\u03b1 \u03c3\u03c4\u03bf\u03bd \u03c0\u03c5\u03c1\u03ae\u03bd\u03b1 (26). \u0397 \u03b4\u03c1\u03ac\u03c3\u03b7 \u03c4\u03bf\u03c5\u03c2 \u03b5\u03be\u03b1\u03c1\u03c4\u03ac\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf \u03c3\u03b5\u03bb\u03ae\u03bd\u03b9\u03bf. \u03a5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03b1\u03c3\u03ac\u03c6\u03b5\u03b9\u03b1 \u03c3\u03c4\u03b7 \u03b2\u03b9\u03b2\u03bb\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5 \u03c4\u03b7\u03bd \u03ba\u03c5\u03c1\u03af\u03b1\u03c1\u03c7\u03b7 \u03c0\u03b7\u03b3\u03ae \u03c0\u03b5\u03c1\u03b9\u03c6\u03b5\u03c1\u03b9\u03ba\u03ae\u03c2 \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae\u03c2 \u03c4\u03b7\u03c2 \u03a43 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03a44. \u0391\u03c1\u03c7\u03b9\u03ba\u03ac \u03b8\u03b5\u03c9\u03c1\u03ae\u03b8\u03b7\u03ba\u03b5 \u03cc\u03c4\u03b9 \u03b7 \u03c0\u03b5\u03c1\u03b9\u03c6\u03b5\u03c1\u03b9\u03ba\u03ae \u03a43 \u03c0\u03c1\u03bf\u03c3\u03ad\u03c1\u03c7\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf \u03ae\u03c0\u03b1\u03c1 \u03ba\u03b1\u03b9 \u03bd\u03b5\u03c6\u03c1\u03cc \u03bc\u03ad\u03c3\u03c9 \u03c4\u03b7\u03c2 D1 (24). \u0391\u03c1\u03b3\u03cc\u03c4\u03b5\u03c1\u03b1 \u03b4\u03b9\u03b1\u03c4\u03c5\u03c0\u03ce\u03b8\u03b7\u03ba\u03b5 \u03b7 \u03ac\u03c0\u03bf\u03c8\u03b7 \u03cc\u03c4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03bf\u03bb\u03cd \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03b7 \u03c3\u03c5\u03bc\u03b2\u03bf\u03bb\u03ae \u03c4\u03b7\u03c2 D2 \u03c3\u03c4\u03b7\u03bd \u03c0\u03b5\u03c1\u03b9\u03c6\u03b5\u03c1\u03b9\u03ba\u03ae \u03bc\u03b5\u03c4\u03b1\u03c4\u03c1\u03bf\u03c0\u03ae \u03c4\u03b7\u03c2 \u03a44 \u03b1\u03c6\u03bf\u03cd \u03b7 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03c0\u03c1\u03bf\u03c0\u03c5\u03bb\u03b8\u03b5\u03b9\u03bf\u03bf\u03c5\u03c1\u03b1\u03ba\u03af\u03bb\u03b7\u03c2 \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03b1\u03bd\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03b5\u03b9 \u03c4\u03b7\u03bd D1 \u03ba\u03b1\u03b9 \u03cc\u03c7\u03b9 \u03c4\u03b7\u03bd D2 \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c0\u03b5\u03c1\u03b9\u03c6\u03b5\u03c1\u03b9\u03ba\u03ae \u03bc\u03b5\u03c4\u03b1\u03c4\u03c1\u03bf\u03c0\u03ae \u03c4\u03b7\u03c2 \u03a43 \u03bc\u03cc\u03bd\u03bf \u03ba\u03b1\u03c4\u03ac 30% (27). \u03a3\u03c4\u03b7\u03bd \u03c3\u03c5\u03bd\u03ad\u03c7\u03b5\u03b9\u03b1 in vitro, \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03ba\u03b9\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c3\u03b5 \u03b1\u03bd\u03b8\u03c1\u03c9\u03c0\u03b9\u03bd\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03ad\u03b4\u03b5\u03b9\u03be\u03b1\u03bd \u03cc\u03c4\u03b9 \u03b7 \u03ba\u03c5\u03c1\u03af\u03b1\u03c1\u03c7\u03b7 \u03c0\u03b7\u03b3\u03ae \u03c4\u03b7\u03c2 \u03a43 \u03bf\u03c1\u03bf\u03cd \u03c3\u03b5 \u03b5\u03c5\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03ba\u03b1\u03b9 \u03c5\u03c0\u03bf\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf\u03b9 \u03c3\u03ba\u03b5\u03bb\u03b5\u03c4\u03b9\u03ba\u03bf\u03af \u03bc\u03cd\u03b5\u03c2 \u03bc\u03ad\u03c3\u03c9 \u03c4\u03b7\u03c2 D2 \u03b5\u03bd\u03ce \u03c3\u03c4\u03bf\u03c5\u03c2 \u03c5\u03c0\u03b5\u03c1\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03c4\u03bf \u03ae\u03c0\u03b1\u03c1 \u03bc\u03ad\u03c3\u03c9 \u03c4\u03b7\u03c2 D1(28). \u03a3\u03c4\u03b7\u03bd \u03c3\u03c5\u03bd\u03ad\u03c7\u03b5\u03b9\u03b1 \u03cc\u03bc\u03c9\u03c2 \u03c6\u03ac\u03bd\u03b7\u03ba\u03b5 \u03cc\u03c4\u03b9 \u03c5\u03c0\u03b5\u03c1\u03b5\u03ba\u03c4\u03b9\u03bc\u03ae\u03b8\u03b7\u03ba\u03b5 \u03b7 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c4\u03b7 D2 \u03c3\u03c4\u03bf \u03c3\u03ba\u03b5\u03bb\u03b5\u03c4\u03b9\u03ba\u03cc \u03bc\u03c5 \u03bb\u03bf\u03b3\u03c9 \u03b5\u03c3\u03c6\u03b1\u03bb\u03bc\u03ad\u03bd\u03b7\u03c2 \u03bc\u03b5\u03b8\u03bf\u03b4\u03bf\u03bb\u03bf\u03b3\u03af\u03b1\u03c2. \u0391\u03c1\u03c7\u03b9\u03ba\u03ac \u03c5\u03c0\u03bf\u03bb\u03bf\u03b3\u03af\u03c3\u03c4\u03b7\u03ba\u03b5 \u03b7 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03bc\u03b5 \u03b2\u03ac\u03c3\u03b5\u03b9 \u03c4\u03bf \u03c0\u03bf\u03c3\u03cc \u03c4\u03bf\u03c5 \u03b9\u03c9\u03b4\u03af\u03bf\u03c5 \u03c0\u03bf\u03c5 \u03b1\u03c0\u03b5\u03bb\u03b5\u03c5\u03b8\u03b5\u03c1\u03ce\u03bd\u03bf\u03bd\u03c4\u03b1\u03bd \u03c4\u03bf \u03bf\u03c0\u03bf\u03af\u03bf \u03cc\u03bc\u03c9\u03c2 \u03b4\u03b5\u03bd \u03c3\u03c5\u03bc\u03b2\u03ac\u03b4\u03b9\u03b6\u03b5 \u03bc\u03b5 \u03c4\u03bf \u03c0\u03bf\u03c3\u03cc \u03c4\u03b7\u03c2 \u03a43 \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03ae\u03c7\u03b8\u03b5\u03b9. \u039f \u03bd\u03ad\u03bf\u03c2 \u03c4\u03c1\u03cc\u03c0\u03bf\u03c2 \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7\u03c2 \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af \u03c4\u03b7\u03bd \u03c7\u03c1\u03ae\u03c3\u03b7 \u03c1\u03b1\u03b4\u03b9\u03bf\u03ca\u03c3\u03bf\u03c4\u03cc\u03c0\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c4\u03bf\u03bd \u03c0\u03c1\u03bf\u03c3\u03b4\u03b9\u03bf\u03c1\u03b9\u03c3\u03bc\u03cc \u03c1\u03b1\u03b4\u03b9\u03bf\u03c3\u03b5\u03c3\u03b7\u03bc\u03b1\u03c3\u03bc\u03ad\u03bd\u03b7\u03c2 \u03a43 \u03bc\u03b5 HPLC \u03c0\u03c1\u03bf\u03ba\u03b5\u03b9\u03bc\u03ad\u03bd\u03bf\u03c5 \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b9\u03bf \u03b1\u03ba\u03c1\u03b9\u03b2\u03b5\u03af\u03c2 \u03bf\u03b9 \u03c0\u03c1\u03bf\u03c3\u03b4\u03b9\u03bf\u03c1\u03b9\u03c3\u03bc\u03bf\u03af (29). \u03a3\u03c4\u03b7\u03bd \u03c3\u03c5\u03bd\u03ad\u03c7\u03b5\u03b9\u03b1 \u03b1\u03bc\u03c6\u03b9\u03c3\u03b2\u03b7\u03c4\u03b7\u03b8\u03b7\u03ba\u03b5 \u03b7 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03bc\u03b2\u03bf\u03bb\u03ae \u03c4\u03b7\u03c2 \u03a43 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd \u03c3\u03ba\u03b5\u03bb\u03b5\u03c4\u03b9\u03ba\u03cc \u03bc\u03c5 (30), \u03b1\u03bd \u03ba\u03b1\u03b9 \u03b7 \u03a43 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c0\u03c1\u03bf\u03ad\u03c1\u03c7\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03ac\u03bb\u03bb\u03b5\u03c2 \u03b8\u03ad\u03c3\u03b5\u03b9\u03c2 \u03cd\u03c0\u03b1\u03c1\u03be\u03b7\u03c2 \u03c4\u03b7\u03c2 D2 (29).<\/p>\n

\u03a0\u03af\u03bd\u03b1\u03ba\u03b1\u03c2 1.<\/b> \u0399\u03b4\u03b9\u03cc\u03c4\u03b7\u03c4\u03b5\u03c2 \u03c4\u03c9\u03bd \u03b1\u03c0\u03bf\u03ca\u03c9\u03b4\u03b9\u03bd\u03b1\u03c3\u03ce\u03bd (\u03b1\u03c0\u03cc \u03c4\u03bf \u03b2\u03b9\u03b2\u03bb\u03af\u03bf \u03c4\u03b7\u03c2 \u0395\u03bd\u03c4\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2 \u0395\u03ba\u03c0\u03b1\u03b9\u03b4\u03b5\u03c5\u03c3\u03b7\u03c2 14\u03bf\u03c2<\/sup> \u03ba\u03cd\u03ba\u03bb\u03bf\u03c2).<\/p>\n

\u00a0\u03a3\u03c4\u03bf \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf \u039c\u0398\u039d \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b1\u03bb\u03bb\u03b1\u03b3\u03ad\u03c2 \u03c3\u03c4\u03b7\u03bd \u03b4\u03c1\u03ac\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b1\u03c0\u03bf\u03ca\u03c9\u03b4\u03b9\u03bd\u03b1\u03c3\u03ce\u03bd \u03ba\u03b1\u03b9 \u03bc\u03ac\u03bb\u03b9\u03c3\u03c4\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03c5\u03c0\u03b5\u03cd\u03b8\u03c5\u03bd\u03b5\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b5\u03ba\u03b4\u03ae\u03bb\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b4\u03c1\u03cc\u03bc\u03bf\u03c5 \u039c\u0398\u039d \u03c3\u03c4\u03b7\u03bd \u03bf\u03be\u03b5\u03af\u03b1 \u03c6\u03ac\u03c3\u03b7. \u0393\u03b5\u03bd\u03b9\u03ba\u03ac \u03b8\u03b5\u03c9\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03b7 \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03b4\u03c1\u03ac\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b7\u03c0\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2 D1 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 D2 \u03c4\u03c9\u03bd \u03c3\u03ba\u03b5\u03bb\u03b5\u03c4\u03b9\u03ba\u03ce\u03bd \u03bc\u03c5\u03ce\u03bd \u03b5\u03bd\u03ce \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c4\u03b7\u03c2 D3 \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03b7\u03bd \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03a43 \u03ba\u03b1\u03b9 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 rT3 (\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 8<\/b>) (2,4,12,31). \u03a0\u03b9\u03b8\u03b1\u03bd\u03ac \u03b7 \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03c9\u03b4\u03ce\u03bd \u03ba\u03c5\u03c4\u03b1\u03c1\u03bf\u03ba\u03b9\u03bd\u03ce\u03bd (32,33) \u03ba\u03b1\u03b9 \u03ba\u03bf\u03c1\u03c4\u03b9\u03b6\u03cc\u03bb\u03b7\u03c2 \u03c4\u03c1\u03bf\u03c0\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03c4\u03b7\u03bd \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03bf\u03c5\u03c2 \u03b1\u03bd \u03ba\u03b1\u03b9 \u03c4\u03b5\u03bb\u03b5\u03c5\u03c4\u03b1\u03af\u03b1 \u03b1\u03c0\u03cc \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c3\u03b5 \u03c0\u03b5\u03b9\u03c1\u03b1\u03bc\u03b1\u03c4\u03cc\u03b6\u03c9\u03b1 \u03c5\u03c0\u03bf\u03c3\u03c4\u03b7\u03c1\u03af\u03c7\u03b8\u03b7\u03ba\u03b5 \u03cc\u03c4\u03b9 \u03bf\u03b9 \u03b1\u03bb\u03bb\u03b1\u03b3\u03ad\u03c2 \u03b1\u03c5\u03c4\u03ad\u03c2 \u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03bf\u03cd\u03bd \u03c4\u03b7\u03bd \u03c0\u03c4\u03ce\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03a43 \u03ba\u03b1\u03b9 \u03b4\u03b5\u03bd \u03c4\u03b7\u03bd \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03bf\u03cd\u03bd. \u03a3\u03b5\u03b9\u03c1\u03ac \u03bc\u03b5\u03bb\u03b5\u03c4\u03ce\u03bd \u03c3\u03b5 \u03c0\u03b5\u03b9\u03c1\u03b1\u03bc\u03b1\u03c4\u03cc\u03b6\u03c9\u03b1 \u03c3\u03c4\u03b1 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c0\u03c1\u03bf\u03ba\u03bb\u03ae\u03b8\u03b7\u03ba\u03b5 \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf \u039c\u0398\u039d \u03bc\u03b5 \u03c4\u03b7\u03bd \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03b5\u03bd\u03b4\u03bf\u03c4\u03bf\u03be\u03af\u03bd\u03b7\u03c2 \u03bc\u03b5 (34) \u03ae \u03c7\u03c9\u03c1\u03af\u03c2 (23) \u03b1\u03c0\u03b1\u03bb\u03bf\u03b9\u03c6\u03ae \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03bf\u03c5 \u03c4\u03b7\u03c2 D1 \u03b5\u03af\u03c4\u03b5 \u03bc\u03b5 \u03b1\u03c0\u03b1\u03bb\u03bf\u03b9\u03c6\u03ae \u03c4\u03bf\u03c5 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 TR\u03b21 (35) \u03bc\u03ad\u03c3\u03c9 \u03c4\u03bf\u03c5 \u03bf\u03c0\u03bf\u03af\u03bf\u03c5 \u03c1\u03c5\u03b8\u03bc\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b7\u03c0\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2 D1, \u03b4\u03b5\u03af\u03c7\u03bd\u03bf\u03c5\u03bd \u03cc\u03c4\u03b9 \u03b7 \u03bc\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03b7\u03c2 D1 \u03bc\u03ac\u03bb\u03bb\u03bf\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03cc\u03c7\u03b9 \u03b1\u03af\u03c4\u03b9\u03bf \u03c4\u03b7\u03c2 \u03c7\u03b1\u03bc\u03b7\u03bb\u03ae\u03c2 \u03a43. \u0395\u03bb\u03ac\u03c7\u03b9\u03c3\u03c4\u03b5\u03c2 \u03b4\u03b7\u03bc\u03bf\u03c3\u03b9\u03b5\u03cd\u03c3\u03b5\u03b9\u03c2 \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03c3\u03b5 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03bf\u03c5\u03c2 \u03c0\u03bf\u03c5 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7\u03c3\u03b1\u03bd \u03c4\u03b7\u03bd \u03b4\u03c1\u03ac\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b1\u03c0\u03bf\u03b9\u03c9\u03b4\u03b9\u03bd\u03b1\u03c3\u03ce\u03bd. \u03a4\u03b1 \u03c4\u03b5\u03bb\u03b5\u03c5\u03c4\u03b1\u03af\u03b1 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03b4\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b7 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1 \u03c3\u03c4\u03b7 \u03b4\u03c1\u03ac\u03c3\u03b7 \u03c4\u03b7\u03c2 D2 \u03c3\u03c4\u03bf \u03c3\u03ba\u03b5\u03bb\u03b5\u03c4\u03b9\u03ba\u03cc \u03bc\u03c5, \u03c4\u03b7\u03c2 \u03bf\u03c0\u03bf\u03af\u03b1\u03c2 \u03b7 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03c3\u03b5 \u03c3\u03c7\u03ad\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03b7\u03c2 D1 \u03c3\u03c4\u03bf \u03ae\u03c0\u03b1\u03c1 (29).<\/p>\n

\n

\"10.26-figure8\"
\n<\/b><\/p>\n

\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 8.<\/b><\/em> \u0391\u03bb\u03bb\u03b1\u03b3\u03ad\u03c2 \u03c4\u03c9\u03bd \u03b1\u03c0\u03bf\u03b9\u03c9\u03b4\u03b9\u03bd\u03b1\u03c3\u03ce\u03bd \u03c3\u03c4\u03bf \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf \u039c\u0398\u039d (31).<\/p>\n

\n

\u0397 \u03bd\u03b7\u03c3\u03c4\u03b5\u03af\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03c0\u03c1\u03ce\u03c4\u03b1 \u03c0\u03b1\u03c1\u03b1\u03b4\u03b5\u03af\u03b3\u03bc\u03b1\u03c4\u03b1 \u03c3\u03c5\u03bd\u03b4\u03c1\u03cc\u03bc\u03bf\u03c5 \u039c\u0398\u039d \u03c3\u03c4\u03b1 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03ac\u03c6\u03b8\u03b7\u03ba\u03b5 \u03b7 \u03b1\u03bb\u03bb\u03b1\u03b3\u03ae \u03c4\u03bf\u03c5 \u03c0\u03b5\u03c1\u03b9\u03c6\u03b5\u03c1\u03b9\u03ba\u03bf\u03cd \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03c3\u03bc\u03bf\u03cd \u03c4\u03c9\u03bd \u0398\u039f (5). \u03a3\u03c4\u03b7\u03bd \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03b1\u03c5\u03c4\u03ae \u03c3\u03b5 4 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03c0\u03bb\u03ae\u03c1\u03bf\u03c5\u03c2 \u03bd\u03b7\u03c3\u03c4\u03b5\u03af\u03b1\u03c2 \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03b7\u03c2 \u03a43 \u03bc\u03b5\u03b9\u03ce\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03b1\u03c5\u03be\u03ac\u03bd\u03bf\u03c5\u03bd \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03bf\u03b9\u03c7\u03b1 \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03b7\u03c2 rT3 \u03c5\u03c0\u03bf\u03b4\u03b7\u03bb\u03ce\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03bc\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03b7\u03c2 D1. \u03a3\u03c4\u03b7\u03bd \u03af\u03b4\u03b9\u03b1 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7, \u03b5\u03c0\u03b1\u03bd\u03b5\u03b9\u03bb\u03b7\u03c6\u03b8\u03b7\u03ba\u03b5 \u03b7 \u03bd\u03b7\u03c3\u03c4\u03b5\u03af\u03b1 \u03c3\u03b5 4 \u03b5\u03b8\u03b5\u03bb\u03bf\u03bd\u03c4\u03ad\u03c2 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03bf\u03c0\u03bf\u03af\u03bf\u03c5\u03c2 \u03c7\u03bf\u03c1\u03b7\u03b3\u03ae\u03b8\u03b7\u03ba\u03b5 \u03b3\u03b9\u03b1 1 \u03bc\u03ae\u03bd\u03b1 \u03b8\u03c5\u03c1\u03bf\u03be\u03af\u03bd\u03b7 \u03ce\u03c3\u03c4\u03b5 \u03bd\u03b1 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03b1\u03bb\u03bf\u03cd\u03bd \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03b7\u03c2 TSH \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03ae\u03c4\u03b1\u03bd \u03c0\u03b1\u03c1\u03cc\u03bc\u03bf\u03b9\u03b1. \u0388\u03ba\u03c4\u03bf\u03c4\u03b5 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b3\u03af\u03bd\u03b5\u03b9 \u03c0\u03bf\u03bb\u03bb\u03ad\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c3\u03b5 \u03bd\u03b7\u03c3\u03c4\u03b5\u03af\u03b1 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c3\u03b5 \u03c0\u03b5\u03b9\u03c1\u03b1\u03bc\u03b1\u03c4\u03cc\u03b6\u03c9\u03b1. \u03a3\u03b5 \u03bc\u03b9\u03ac \u03c0\u03c1\u03cc\u03c3\u03c6\u03b1\u03c4\u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03c3\u03b5 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03bf\u03c5\u03c2 \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03b8\u03b7\u03ba\u03b5 \u03b7 \u03b4\u03c1\u03ac\u03c3\u03b7 \u03c3\u03ba\u03b5\u03bb\u03b5\u03c4\u03b9\u03ba\u03ae\u03c2 D2 \u03c3\u03b5 6 \u03c5\u03b3\u03b9\u03b5\u03af\u03c2 \u03b5\u03b8\u03b5\u03bb\u03bf\u03bd\u03c4\u03ad\u03c2 \u03c0\u03bf\u03c5 \u03bd\u03ae\u03c3\u03c4\u03b5\u03c8\u03b1\u03bd \u03ba\u03b1\u03b9 \u03b2\u03c1\u03ad\u03b8\u03b7\u03ba\u03b5 \u03cc\u03c4\u03b9 \u03b7 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c3\u03ba\u03b5\u03bb\u03b5\u03c4\u03b9\u03ba\u03ae\u03c2 D2 \u03bc\u03b5\u03b9\u03ce\u03b8\u03b7\u03ba\u03b5 \u03c3\u03c4\u03b9\u03c2 62 \u03ce\u03c1\u03b5\u03c2 \u03bd\u03b7\u03c3\u03c4\u03b5\u03af\u03b1\u03c2 \u03b5\u03bd\u03ce \u03b7 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03b4\u03b5\u03bd \u03ac\u03bb\u03bb\u03b1\u03be\u03b5 (30). \u03a0\u03b1\u03c1\u03cc\u03bc\u03bf\u03b9\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03b1 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03c3\u03ba\u03b5\u03bb\u03b5\u03c4\u03b9\u03ba\u03ae D2 \u03c3\u03c4\u03b7 \u03bd\u03b7\u03c3\u03c4\u03b5\u03af\u03b1 \u03c3\u03b5 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03bf\u03c5\u03c2 \u03b5\u03c7\u03bf\u03c5\u03bd \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03b1\u03c6\u03b5\u03af \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03c3\u03b7\u03c0\u03c4\u03b9\u03ba\u03cc shock. \u03a3\u03b5 13 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03c3\u03b7\u03c0\u03c4\u03b9\u03ba\u03cc shock 5 \u03b7\u03bc\u03ad\u03c1\u03b5\u03c2 \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7\u03bd \u03b5\u03af\u03c3\u03bf\u03b4\u03bf \u03c4\u03bf\u03c5\u03c2 \u03c3\u03c4\u03b7\u03bd \u039c\u0395\u0398, \u03c3\u03b5 \u03b2\u03b9\u03bf\u03c8\u03af\u03b5\u03c2 \u03c3\u03ba\u03b5\u03bb\u03b5\u03c4\u03b9\u03ba\u03bf\u03cd \u03bc\u03c5\u03cc\u03c2 \u03ba\u03b1\u03b9 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c1\u03af\u03bf\u03c5 \u03bb\u03af\u03c0\u03bf\u03c5\u03c2, \u03b7 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c3\u03ba\u03b5\u03bb\u03b5\u03c4\u03b9\u03ba\u03ae\u03c2 D2 \u03ae\u03c4\u03b1\u03bd \u03bc\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03b5\u03bd\u03ce \u03b7 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03b4\u03b5 \u03b4\u03b9\u03ad\u03c6\u03b5\u03c1\u03b5 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03bf\u03bc\u03ac\u03b4\u03b1 \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5 (36).<\/p>\n

\u0391\u03bd\u03c4\u03af\u03b8\u03b5\u03c4\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03c3\u03b5 \u03c3\u03c7\u03ad\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b9\u03c2 \u03c0\u03c1\u03bf\u03b7\u03b3\u03bf\u03cd\u03bc\u03b5\u03bd\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b2\u03c1\u03b5\u03b8\u03b5\u03af \u03c3\u03b5 \u03b2\u03b1\u03c1\u03ad\u03c9\u03c2 \u03c0\u03ac\u03c3\u03c7\u03bf\u03bd\u03c4\u03b5\u03c2. \u03a3\u03b5 \u03b1\u03c5\u03c4\u03ae \u03c4\u03b7\u03bd \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b1 \u03c4\u03c9\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03b8\u03b7\u03ba\u03b1\u03bd \u03bf\u03b9 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ad\u03c2 \u03bf\u03c1\u03bc\u03cc\u03bd\u03b5\u03c2 \u03c4\u03bf\u03c5 \u03bf\u03c1\u03bf\u03cd \u03ba\u03b1\u03b9 \u03bf\u03b9 D1, D2, D3 \u03c3\u03c4\u03bf \u03ae\u03c0\u03b1\u03c1 \u03ba\u03b1\u03b9 \u03c4\u03bf\u03bd \u03c3\u03ba\u03b5\u03bb\u03b5\u03c4\u03b9\u03ba\u03cc \u03bc\u03c5 \u03b5\u03bd\u03c4\u03cc\u03c2 \u03bc\u03b9\u03c3\u03ae\u03c2 \u03ce\u03c1\u03b1\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf \u03b8\u03ac\u03bd\u03b1\u03c4\u03bf \u03c4\u03bf\u03c5\u03c2. \u03a3\u03c4\u03b7\u03bd \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03b1\u03c5\u03c4\u03ae \u03c6\u03ac\u03bd\u03b7\u03ba\u03b5 \u03cc\u03c4\u03b9 \u03b7 \u03b4\u03c1\u03ac\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b7\u03c0\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2 D1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b7 \u03c4\u03bf\u03c5 \u03bb\u03cc\u03b3\u03bf\u03c5 \u03a43\/rT3 \u03bf\u03c1\u03bf\u03cd \u03b5\u03bd\u03ce \u03c4\u03b7\u03c2 \u03b7\u03c0\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2 D3 \u03b1\u03bd\u03c4\u03b9\u03c3\u03c4\u03c1\u03cc\u03c6\u03c9\u03c2 \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b7. \u0388\u03c4\u03c3\u03b9 \u03bb\u03bf\u03b9\u03c0\u03cc\u03bd, \u03bf\u03b9 \u03b1\u03bb\u03bb\u03b1\u03b3\u03ad\u03c2 \u03c4\u03c9\u03bd \u03b1\u03c0\u03bf\u03ca\u03c9\u03b4\u03b9\u03bd\u03b1\u03c3\u03ce\u03bd \u03c3\u03c5\u03bc\u03b2\u03ac\u03bb\u03bb\u03bf\u03c5\u03bd \u03c3\u03c4\u03b7\u03bd \u03c0\u03c4\u03ce\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03a43 \u03c7\u03c9\u03c1\u03af\u03c2 \u03cc\u03bc\u03c9\u03c2 \u03bd\u03b1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b1\u03c0\u03bf\u03b4\u03b5\u03b9\u03c7\u03b8\u03b5\u03af \u03b5\u03ac\u03bd \u03bf\u03b9 \u03b1\u03bb\u03bb\u03b1\u03b3\u03ad\u03c2 \u03b1\u03c5\u03c4\u03ad\u03c2 \u03c0\u03c1\u03bf\u03b7\u03b3\u03ae\u03b8\u03b7\u03ba\u03b1\u03bd \u03ae \u03b1\u03c0\u03bb\u03ac \u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b1\u03bd \u03c4\u03b7\u03bd \u03c0\u03c4\u03ce\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03a43 (37). \u03a3\u03c4\u03b7\u03bd \u03af\u03b4\u03b9\u03b1 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7, \u03b1\u03be\u03af\u03b6\u03b5\u03b9 \u03bd\u03b1 \u03c3\u03b7\u03bc\u03b5\u03b9\u03c9\u03b8\u03b5\u03af \u03cc\u03c4\u03b9 \u03b4\u03b5\u03bd \u03b1\u03bd\u03b9\u03c7\u03bd\u03b5\u03cd\u03c4\u03b7\u03ba\u03b5 \u03b4\u03c1\u03ac\u03c3\u03b7 \u03c4\u03b7\u03c2 D2 \u03bf\u03cd\u03c4\u03b5 \u03c3\u03c4\u03bf \u03ae\u03c0\u03b1\u03c1 \u03bf\u03cd\u03c4\u03b5 \u03c3\u03c4\u03bf \u03c3\u03ba\u03b5\u03bb\u03b5\u03c4\u03b9\u03ba\u03cc \u03bc\u03c5. \u03a0\u03b1\u03c1\u03b1\u03b4\u03cc\u03be\u03c9\u03c2 \u03cc\u03bc\u03c9\u03c2, \u03b7 \u03af\u03b4\u03b9\u03b1 \u03bf\u03bc\u03ac\u03b4\u03b1 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03ce\u03bd \u03c3\u03b5 \u03bc\u03b9\u03b1 \u03b5\u03c0\u03cc\u03bc\u03b5\u03bd\u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03c4\u03bf\u03c5\u03c2, \u03bc\u03b5 \u03c0\u03b1\u03c1\u03cc\u03bc\u03bf\u03b9\u03bf \u03c3\u03c7\u03b5\u03b4\u03b9\u03b1\u03c3\u03bc\u03cc \u03b2\u03c1\u03ae\u03ba\u03b1\u03bd \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03c3\u03ba\u03b5\u03bb\u03b5\u03c4\u03b9\u03ba\u03ae\u03c2 D2 \u03c3\u03b5 \u03b2\u03b1\u03c1\u03ad\u03c9\u03c2 \u03c0\u03ac\u03c3\u03c7\u03bf\u03bd\u03c4\u03b5\u03c2 \u03bc\u03b5 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b5\u03c4\u03b1\u03bc\u03ad\u03bd\u03b7 \u03bd\u03bf\u03c3\u03b7\u03bb\u03b5\u03af\u03b1 \u03c3\u03b5 \u03c3\u03c7\u03ad\u03c3\u03b7 \u03bc\u03b5 \u03b1\u03c5\u03c4\u03bf\u03cd\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03ad\u03b8\u03b1\u03b9\u03bd\u03b1\u03bd \u03bf\u03be\u03ad\u03c9\u03c2 \u03ae \u03c4\u03bf\u03c5\u03c2 \u03c5\u03b3\u03b9\u03b5\u03af\u03c2 \u03bc\u03ac\u03c1\u03c4\u03c5\u03c1\u03b5\u03c2 (38). \u03a4\u03b7\u03bd \u03b1\u03bd\u03c4\u03af\u03c6\u03b1\u03c3\u03b7 \u03b1\u03c5\u03c4\u03ae \u03b1\u03c0\u03bf\u03b4\u03af\u03b4\u03bf\u03c5\u03bd \u03bf\u03b9 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03ad\u03c2 \u03c3\u03b5 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ae \u03bc\u03b5\u03b8\u03bf\u03b4\u03bf\u03bb\u03bf\u03b3\u03b9\u03b1 \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c4\u03b7\u03c2 D2.<\/p>\n

\u03a4\u03bf \u03b8\u03ad\u03bc\u03b1 \u03c4\u03bf\u03c5 \u03c0\u03b5\u03c1\u03b9\u03c6\u03b5\u03c1\u03b9\u03ba\u03bf\u03cd \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03c3\u03bc\u03bf\u03cd \u03c4\u03c9\u03bd \u0398\u039f \u03cc\u03c0\u03c9\u03c2 \u03c0\u03c1\u03bf\u03ba\u03cd\u03c0\u03c4\u03b5\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03c0\u03bf\u03bb\u03c5\u03ac\u03c1\u03b9\u03b8\u03bc\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b3\u03af\u03bd\u03b5\u03b9 \u03c4\u03b1 \u03c4\u03b5\u03bb\u03b5\u03c5\u03c4\u03b1\u03af\u03b1 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c3\u03b5 \u03c0\u03b5\u03b9\u03c1\u03b1\u03bc\u03b1\u03c4\u03cc\u03b6\u03c9\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03be\u03b1\u03b9\u03c1\u03b5\u03c4\u03b9\u03ba\u03ac \u03c0\u03bf\u03bb\u03cd\u03c0\u03bb\u03bf\u03ba\u03bf \u03ba\u03b1\u03b9 \u03b5\u03be\u03b5\u03b9\u03b4\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03bf. \u03a0\u03b9\u03bf \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b1 \u03b7 \u03b4\u03c1\u03ac\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b1\u03c0\u03bf\u03b9\u03c9\u03b4\u03b9\u03bd\u03b1\u03c3\u03c9\u03bd \u03b5\u03be\u03b1\u03c1\u03c4\u03ac\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf \u03b5\u03af\u03b4\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03bd\u03bf\u03c3\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2, \u03c4\u03b7\u03bd \u03c6\u03ac\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03bd\u03bf\u03c3\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd \u03b9\u03c3\u03c4\u03cc \u03c0\u03bf\u03c5 \u03b5\u03be\u03b5\u03c4\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 (\u03b1\u03bd\u03b1\u03bb\u03c5\u03c4\u03b9\u03ba\u03ac \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03ac\u03c6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b1\u03bd\u03b1\u03c3\u03ba\u03cc\u03c0\u03b7\u03c3\u03b7 (39)) (\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 9<\/b>).<\/p>\n

\n

\u00a0\"10.26-figure9\"<\/p>\n

\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 9.<\/strong><\/em> \u0391\u03bb\u03bb\u03b1\u03b3\u03ad\u03c2 \u03c4\u03c9\u03bd \u03b1\u03c0\u03bf\u03b9\u03c9\u03b4\u03b9\u03bd\u03b1\u03c3\u03ce\u03bd \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03bf \u03bd\u03cc\u03c3\u03b7\u03bc\u03b1, \u03c4\u03b7 \u03c6\u03ac\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03bd\u03bf\u03c3\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03bf\u03bd \u03b9\u03c3\u03c4\u03cc.<\/p>\n

\n
3.3. \u039f \u03c1\u03cc\u03bb\u03bf\u03c2 \u03c4\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03ba\u03b9\u03bd\u03ce\u03bd <\/b><\/h5>\n

\u03a3\u03c4\u03b7\u03bd \u03c0\u03b1\u03b8\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1 \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b4\u03c1\u03cc\u03bc\u03bf\u03c5 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b5\u03bd\u03bf\u03c7\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03b5\u03af \u03bf\u03b9 \u03c0\u03c1\u03bf\u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ce\u03b4\u03b5\u03b9\u03c2 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03ba\u03af\u03bd\u03b5\u03c2. \u0397 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03ba\u03c5\u03c4\u03b1\u03c1\u03bf\u03ba\u03b9\u03bd\u03ce\u03bd \u03c3\u03b5 \u03c5\u03b3\u03b9\u03ae \u03c4\u03c1\u03c9\u03ba\u03c4\u03b9\u03ba\u03ac \u03ae \u03c5\u03b3\u03b9\u03b5\u03af\u03c2 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03bf\u03c5\u03c2 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03c2 \u03b1\u03bb\u03bb\u03b1\u03b3\u03ad\u03c2 \u03bc\u03b5 \u03b1\u03c5\u03c4\u03ad\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf \u039c\u0398\u039d (\u03a0\u03af\u03bd\u03b1\u03ba\u03b1\u03c2 2<\/b>) (39). \u03a3\u03b5 \u03ac\u03bb\u03bb\u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 in vitro, \u03b7 \u03c0\u03c1\u03bf\u03c3\u03b8\u03ae\u03ba\u03b7 IL-6 \u03c3\u03b5 \u03ba\u03b1\u03bb\u03bb\u03b9\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2 \u03b1\u03bd\u03b8\u03c1\u03c9\u03c0\u03af\u03bd\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03b1\u03bd\u03ad\u03c3\u03c4\u03b5\u03b9\u03bb\u03b5 \u03c4\u03b7\u03bd \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03b7\u03c2 D1 \u03ba\u03b1\u03b9 \u03b5\u03c0\u03ae\u03b3\u03b1\u03b3\u03b5 \u03c4\u03b7\u03bd \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03b7\u03c2 D3 (40). \u0398\u03b1 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03c3\u03b1\u03bd \u03bf\u03b9 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03ba\u03af\u03bd\u03b5\u03c2 \u03bd\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03bf\u03cd\u03bd \u03c4\u03bf\u03bd \u03ba\u03bf\u03b9\u03bd\u03cc \u03b4\u03b9\u03b1\u03bc\u03b5\u03c3\u03bf\u03bb\u03b1\u03b2\u03b7\u03c4\u03ae \u03b1\u03bd\u03ac\u03bc\u03b5\u03c3\u03b1 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c4\u03b5\u03c1\u03bf\u03b3\u03b5\u03bd\u03ae \u03bf\u03bc\u03ac\u03b4\u03b1 \u03c4\u03c9\u03bd \u03bd\u03bf\u03c3\u03b7\u03bc\u03ac\u03c4\u03c9\u03bd \u03ba\u03b1\u03b9 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03ac\u03c3\u03b5\u03c9\u03bd \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03c4\u03bf \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03b5\u03be\u03b7\u03b3\u03ae\u03c3\u03bf\u03c5\u03bd \u03c4\u03b9\u03c2 \u03ba\u03bf\u03b9\u03bd\u03ad\u03c2 \u03b1\u03bb\u03bb\u03b1\u03b3\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9. \u038c\u03bc\u03c9\u03c2 \u03bf \u03c1\u03cc\u03bb\u03bf\u03c2 \u03c4\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03ba\u03b9\u03bd\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c0\u03b9\u03bf \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b1 \u03c4\u03bf\u03c5 TNF\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 IL-6 \u03c3\u03c4\u03b7\u03bd \u03b5\u03ba\u03b4\u03ae\u03bb\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b4\u03c1\u03cc\u03bc\u03bf\u03c5 \u039c\u0398\u039d \u03b4\u03b5\u03bd \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03b9\u03ce\u03b8\u03b7\u03ba\u03b5 \u03c3\u03b5 \u03cc\u03bb\u03b5\u03c2 \u03c4\u03b9\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2. \u03a3\u03b5 \u03c0\u03c1\u03bf\u03b3\u03c1\u03b1\u03bc\u03bc\u03b1\u03c4\u03b9\u03c3\u03bc\u03ad\u03bd\u03b1 \u03c7\u03b5\u03b9\u03c1\u03bf\u03c5\u03c1\u03b3\u03b5\u03af\u03b1 \u03b7 \u03c0\u03c4\u03ce\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c0\u03c1\u03bf\u03b7\u03b3\u03ae\u03b8\u03b7\u03ba\u03b5 \u03c4\u03b7\u03c2 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 IL-6 \u03b5\u03bd\u03ce \u03b4\u03b5\u03bd \u03b5\u03af\u03c7\u03b5 \u03ba\u03b1\u03bc\u03b9\u03ac \u03c3\u03c5\u03c3\u03c7\u03ad\u03c4\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03bf\u03bd TNF\u03b1. \u0395\u03c0\u03bf\u03bc\u03ad\u03bd\u03c9\u03c2 \u03b4\u03b5\u03bd \u03b1\u03c0\u03b5\u03b4\u03b5\u03af\u03c7\u03b8\u03b7 \u03b7 \u03b1\u03b9\u03c4\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03c3\u03c5\u03c3\u03c7\u03ad\u03c4\u03b9\u03c3\u03b7 \u03c4\u03bf\u03c5\u03c2 (9).<\/p>\n

\u03a0\u03af\u03bd\u03b1\u03ba\u03b1\u03c2 2. \u0391\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7\u03c2 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03ba\u03b9\u03bd\u03ce\u03bd \u03c3\u03b5 \u03c4\u03c1\u03c9\u03ba\u03c4\u03b9\u03ba\u03ac \u03ba\u03b1\u03b9 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03bf\u03c5\u03c2 (39).<\/p>\n

4. \u0395\u03af\u03bd\u03b1\u03b9 \u03c5\u03c0\u03bf\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03cc\u03c2 \u03bf \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2;<\/b><\/h4>\n

\u03a0\u03c1\u03bf\u03ba\u03b5\u03b9\u03bc\u03ad\u03bd\u03bf\u03c5 \u03bd\u03b1 \u03b1\u03c0\u03b1\u03bd\u03c4\u03ae\u03c3\u03b5\u03b9 \u03ba\u03b1\u03bd\u03b5\u03af\u03c2 \u03c4\u03bf \u03b5\u03c1\u03ce\u03c4\u03b7\u03bc\u03b1 \u03c4\u03bf\u03c5 \u03b5\u03ac\u03bd \u03c4\u03b5\u03bb\u03b9\u03ba\u03ac \u03bf \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c5\u03c0\u03bf\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03cc\u03c2, \u03b8\u03b1 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03b9 \u03b1\u03c6\u03b5\u03bd\u03cc\u03c2 \u03c4\u03b9\u03c2 \u03b5\u03bd\u03b4\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03b9\u03b5\u03c2 \u03c3\u03c5\u03b3\u03ba\u03b5\u03bd\u03c4\u03c1\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c4\u03c9\u03bd \u0398\u039f \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c3\u03cd\u03bd\u03b4\u03b5\u03c3\u03b7 \u03c4\u03bf\u03c5\u03c2 \u03bc\u03b5 \u03c4\u03bf\u03c5\u03c2 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03b5\u03af\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b4\u03b9\u03ac\u03c6\u03bf\u03c1\u03bf\u03c5\u03c2 \u03b9\u03c3\u03c4\u03bf\u03cd\u03c2. \u0397 \u03b5\u03bd\u03b4\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03b9\u03b1 \u03c3\u03c5\u03b3\u03ba\u03ad\u03bd\u03c4\u03c1\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd \u0398\u039f \u03b5\u03be\u03b1\u03c1\u03c4\u03ac\u03c4\u03b1\u03b9 \u03b1\u03c6\u03b5\u03bd\u03cc\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03bf\u03cd\u03bd\u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c3\u03c4\u03bf \u03b1\u03af\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03b1\u03c6\u03b5\u03c4\u03ad\u03c1\u03bf\u03c5 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b4\u03c5\u03bd\u03b1\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1 \u03bd\u03b1 \u03b5\u03b9\u03c3\u03ad\u03bb\u03b8\u03bf\u03c5\u03bd \u03c3\u03c4\u03bf \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03bf \u03bc\u03ad\u03c3\u03c9 \u03c4\u03c9\u03bd ATP \u03b5\u03be\u03b1\u03c1\u03c4\u03ce\u03bc\u03b5\u03bd\u03c9\u03bd \u03bc\u03b5\u03c4\u03b1\u03c6\u03bf\u03c1\u03ad\u03c9\u03bd \u03c4\u03bf\u03c5\u03c2 \u03ba\u03b1\u03b8\u03ce\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03c9\u03bd \u03b5\u03bd\u03b4\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03b9\u03c9\u03bd \u03b1\u03c0\u03bf\u03ca\u03c9\u03b4\u03b9\u03bd\u03ac\u03c3\u03c9\u03bd (\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 10<\/b>). \u03a3\u03b5 \u03bc\u03b9\u03b1 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03bd\u03bf\u03c3\u03b7\u03bb\u03b5\u03c5\u03bc\u03ad\u03bd\u03c9\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03c3\u03b5 \u039c\u0395\u0398 \u03bf\u03b9 \u03bf\u03c0\u03bf\u03af\u03bf\u03b9 \u03c4\u03b5\u03bb\u03b9\u03ba\u03ac \u03c0\u03ad\u03b8\u03b1\u03bd\u03b1\u03bd, \u03b2\u03c1\u03ad\u03b8\u03b7\u03ba\u03b5 \u03cc\u03c4\u03b9 \u03bf\u03b9 \u03b5\u03bd\u03b4\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03b9\u03b5\u03c2 \u03c3\u03c5\u03b3\u03ba\u03b5\u03bd\u03c4\u03c1\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c4\u03c9\u03bd \u0398\u039f \u03c3\u03c4\u03bf \u03ae\u03c0\u03b1\u03c1 \u03ba\u03b1\u03b9 \u03c3\u03ba\u03b5\u03bb\u03b5\u03c4\u03b9\u03ba\u03cc \u03bc\u03c5 \u03ae\u03c4\u03b1\u03bd \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b5\u03c2 \u03c4\u03bf\u03c5 \u03c0\u03bb\u03ac\u03c3\u03bc\u03b1\u03c4\u03bf\u03c2. \u03a3\u03c4\u03b7\u03bd \u03b9\u03b4\u03b9\u03b1 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03c6\u03b1\u03bd\u03b7\u03ba\u03b5 \u03cc\u03c4\u03b9 \u03b7 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03c9\u03bd \u03bc\u03b5\u03bc\u03b2\u03c1\u03b1\u03bd\u03b9\u03ba\u03ce\u03bd \u03bc\u03b5\u03c4\u03b1\u03c6\u03bf\u03c1\u03ad\u03c9\u03bd \u03b4\u03b5\u03bd \u03b5\u03c0\u03b7\u03c1\u03ad\u03b1\u03b6\u03b5 \u03c4\u03b7\u03bd \u03b5\u03bd\u03b4\u03bf\u03ba\u03c5\u03c4\u03ac\u03c1\u03b9\u03b1 \u03c3\u03c5\u03b3\u03ba\u03ad\u03bd\u03c4\u03c1\u03c9\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b5\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03b8\u03b7\u03ba\u03b5 \u03b7 \u03b4\u03c1\u03ac\u03c3\u03b7 \u03c4\u03c9\u03bd D1, D2, D3 (41).<\/p>\n

\n

\u00a0\"10.26-figure10\"<\/p>\n

\u00a0\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 10.<\/strong><\/em> \u0395\u03bd\u03b4\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03b9\u03b1 \u03b4\u03c1\u03ac\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03bf\u03c1\u03bc\u03bf\u03bd\u03ce\u03bd.<\/p>\n

\n

\u038c\u03c3\u03bf\u03bd \u03b1\u03c6\u03bf\u03c1\u03ac \u03c4\u03ce\u03c1\u03b1 \u03c4\u03b7\u03bd \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03c9\u03bd \u03c4\u03b7\u03c2 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ae\u03c2 \u03bf\u03c1\u03bc\u03cc\u03bd\u03b7\u03c2 \u03a43 \u03c3\u03b5 \u03b4\u03b9\u03ac\u03c6\u03bf\u03c1\u03bf\u03c5\u03c2 \u03b9\u03c3\u03c4\u03bf\u03cd\u03c2 \u03c3\u03b5 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03bf\u03c5\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03ac\u03bb\u03b9 \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03bc\u03b9\u03b1 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c0\u03c1\u03bf\u03ad\u03c1\u03c7\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b9\u03b4\u03b9\u03b1 \u03bf\u03bc\u03ac\u03b4\u03b1 \u03bc\u03b5 \u03c0\u03b1\u03c1\u03bf\u03bc\u03bf\u03b9\u03bf \u03c3\u03c7\u03b5\u03b4\u03b9\u03b1\u03c3\u03bc\u03cc \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u039c\u0395\u0398 \u03c0\u03bf\u03c5 \u03c0\u03ad\u03b8\u03b1\u03bd\u03b1\u03bd \u03ba\u03b1\u03b9 \u03ad\u03bb\u03b1\u03b2\u03b1\u03bd \u03b2\u03b9\u03bf\u03c8\u03af\u03b5\u03c2 \u03b7\u03c0\u03b1\u03c4\u03bf\u03c2. \u03a3\u03c4\u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03b1\u03c5\u03c4\u03ae \u03b2\u03c1\u03ad\u03b8\u03b7\u03ba\u03b5 \u03cc\u03c4\u03b9 \u03b7 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 TR\u03b11 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03c3\u03b5 58 \u03b1\u03c0\u03bf\u03b8\u03b1\u03bd\u03cc\u03bd\u03c4\u03b5\u03c2 \u03c3\u03c4\u03b7\u03bd \u039c\u0395\u0398 \u03c3\u03c5\u03b3\u03ba\u03c1\u03b9\u03bd\u03cc\u03bc\u03b5\u03bd\u03b5\u03c2 \u03bc\u03b5 3 \u03c5\u03b3\u03b9\u03b5\u03b9\u03c2 \u03ba\u03b1\u03b9 \u03b5\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd \u03bf \u03bb\u03cc\u03b3\u03bf\u03c2 TR\u03b11\/TR\u03b12 \u03c3\u03c5\u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b8\u03b5\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5 \u03c4\u03b7 \u03c3\u03bf\u03b2\u03b1\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b7\u03bb\u03b9\u03ba\u03af\u03b1. \u0397 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03ba\u03cd\u03c1\u03b9\u03bf\u03c5 \u03b7\u03c0\u03b1\u03c4\u03b9\u03ba\u03bf\u03cd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 TR\u03b21 \u03b4\u03b5\u03bd \u03ad\u03b4\u03b5\u03b9\u03be\u03b5 \u03c3\u03c5\u03c3\u03c7\u03ad\u03c4\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03ba\u03b1\u03bc\u03af\u03b1 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bb\u03b7\u03c4\u03ae. \u039f TR\u03b12 \u03b4\u03b5\u03bd \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03a43 \u03ba\u03b1\u03b9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03b5\u03b9 \u03c4\u03b7\u03bd \u03bc\u03b5\u03c4\u03b1\u03b3\u03c1\u03b1\u03c6\u03ae. \u03a4\u03b1 \u03b5\u03c5\u03c1\u03ae\u03bc\u03b1\u03c4\u03b1 \u03b1\u03c5\u03c4\u03ac \u03c5\u03c0\u03bf\u03b4\u03b7\u03bb\u03ce\u03bd\u03bf\u03c5\u03bd \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ac \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03af\u03b1 \u03c4\u03c9\u03bd \u03b9\u03c3\u03c4\u03ce\u03bd \u03c3\u03c4\u03b7\u03bd \u03a43 \u03b1\u03bd\u03c4\u03b9\u03c1\u03c1\u03bf\u03c0\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b1 \u03c7\u03b1\u03bc\u03b7\u03bb\u03ac \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03a43 \u03c3\u03c4\u03bf \u03c0\u03bb\u03ac\u03c3\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03bf \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03bf \u03b1\u03bd \u03ba\u03b1\u03b9 \u03cc\u03c0\u03c9\u03c2 \u03b1\u03bd\u03b1\u03c6\u03ad\u03c1\u03b8\u03b7\u03ba\u03b5 \u03bf TR\u03b11 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf \u03b5\u03c0\u03b9\u03ba\u03c1\u03b1\u03c4\u03ce\u03bd \u03c4\u03cd\u03c0\u03bf\u03c2 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03c3\u03c4\u03bf \u03ae\u03c0\u03b1\u03c1 (42).<\/p>\n

\u0395\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03c1\u03cc\u03bb\u03bf \u03c3\u03c4\u03b7 \u03b4\u03c1\u03ac\u03c3\u03b7 \u03c4\u03c9\u03bd \u0398\u039f \u03c0\u03b1\u03af\u03b6\u03b5\u03b9 \u03ba\u03b1\u03b9 \u03b4\u03b9\u03b1\u03b8\u03b5\u03c3\u03b9\u03bc\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03c9\u03bd \u03b5\u03bd\u03b4\u03bf\u03ba\u03c5\u03c4\u03ac\u03c1\u03b9\u03c9\u03bd \u03c3\u03c5\u03bd-\u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03ce\u03bd\/\u03c3\u03c5\u03bd-\u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03b1\u03bb\u03c4\u03ce\u03bd \u03c4\u03c9\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03c9\u03bd \u03c4\u03bf\u03c5\u03c2. \u03a0\u03b1\u03c1\u03ac\u03b4\u03b5\u03b9\u03b3\u03bc\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03b7 \u03bc\u03b5\u03b9\u03c9\u03c1\u03cd\u03b8\u03bc\u03b9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b7\u03c0\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2 D1 \u03c3\u03c4\u03b7\u03bd \u03bf\u03be\u03b5\u03b9\u03b1 \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03b7. \u0397 \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03c0\u03c1\u03bf\u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03c9\u03b4\u03ce\u03bd \u03ba\u03c5\u03c4\u03b1\u03c1\u03bf\u03ba\u03b9\u03bd\u03ce\u03bd \u03b5\u03c0\u03ac\u03b3\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03b7\u03c0\u03b1\u03c4\u03b9\u03ba\u03ce\u03bd \u03c0\u03c1\u03c9\u03c4\u03b5\u03b9\u03bd\u03ce\u03bd \u03bf\u03be\u03b5\u03af\u03b1\u03c2 \u03c6\u03ac\u03c3\u03b7\u03c2 \u03b5\u03be\u03b1\u03bd\u03c4\u03bb\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c4\u03bf\u03bd \u03ba\u03bf\u03b9\u03bd\u03cc \u03c3\u03c5\u03bd-\u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03ae SRC-1 \u03c4\u03bf\u03c5 TR\u03b21. \u0397 \u03c0\u03c1\u03bf\u03c3\u03b8\u03ae\u03ba\u03b7 SRC-1 \u03b1\u03c0\u03bf\u03ba\u03b1\u03b8\u03b9\u03c3\u03c4\u03ac \u03b5\u03bd \u03bc\u03ad\u03c1\u03b5\u03b9 \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03bf\u03c5 mRNA \u03c4\u03b7\u03c2 \u03b7\u03c0\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2 D1 (32).<\/p>\n

5. \u0394\u03b9\u03b1\u03c6\u03bf\u03c1\u03b9\u03ba\u03ae <\/b>\u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7<\/b><\/h4>\n

\u03a4\u03bf \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf \u039c\u0398\u039d \u03b8\u03b1 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03bf\u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03b8\u03b5\u03af \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03ba\u03ac\u03c4\u03c9\u03b8\u03b9 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2:<\/p>\n

    \n
  1. \u0391\u03c0\u03cc \u03c0\u03c1\u03bf\u03cb\u03c0\u03ac\u03c1\u03c7\u03bf\u03bd\u03c4\u03b1 \u03c5\u03c0\u03b5\u03c1\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03c3\u03bc\u03cc \u03c3\u03b5 \u03bd\u03bf\u03c3\u03bf\u03cd\u03bd\u03c4\u03b1. \u03a3\u03b5 \u03b1\u03c5\u03c4\u03ae \u03c4\u03b7\u03bd \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03b2\u03bf\u03b7\u03b8\u03ac \u03b7 \u03cd\u03c0\u03b1\u03c1\u03be\u03b7 \u03c4\u03b1\u03c7\u03c5\u03ba\u03b1\u03c1\u03b4\u03af\u03b1\u03c2 \u03b7 \u03ba\u03bf\u03bb\u03c0\u03b9\u03ba\u03ae\u03c2 \u03bc\u03b1\u03c1\u03bc\u03b1\u03c1\u03c5\u03b3\u03ae\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03c0\u03bf\u03bb\u03cd \u03c7\u03b1\u03bc\u03b7\u03bb\u03ac \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 TSH < 0,01 \u03bcU\/mL \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03b7\u03c2 \u03a43 \u03c4\u03b1 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03c1\u03bf\u03c2 \u03c4\u03b1 \u03b1\u03bd\u03ce\u03c4\u03b5\u03c1\u03b1 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03cc\u03c1\u03b9\u03b1 (43).<\/li>\n
  2. \u0391\u03c0\u03cc \u03c5\u03c0\u03bf\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03c3\u03bc\u03cc \u03c3\u03c4\u03b7\u03bd \u03c6\u03ac\u03c3\u03b7 \u03b1\u03bd\u03ac\u03c1\u03c1\u03c9\u03c3\u03b7\u03c2. \u03a3\u03c4\u03b7\u03bd \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03b1\u03c5\u03c4\u03ae \u03b5\u03ac\u03bd \u03bc\u03b5\u03c4\u03c1\u03b7\u03b8\u03bf\u03cd\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ad\u03c2 \u03bf\u03c1\u03bc\u03cc\u03bd\u03b5\u03c2 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae \u03c0\u03bf\u03c5 \u03b1\u03bd\u03b1\u03bd\u03ae\u03c0\u03c4\u03b5\u03b9 \u03ba\u03b1\u03b9 \u03b2\u03b5\u03bb\u03c4\u03b9\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03c5\u03b3\u03b5\u03af\u03b1 \u03c4\u03bf\u03c5, \u03c4\u03cc\u03c4\u03b5 \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03b7\u03c2 \u03a4SH \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03b1 \u03c0\u03c1\u03ce\u03c4\u03b1 \u03c0\u03bf\u03c5 \u03b1\u03bd\u03b5\u03b2\u03b1\u03af\u03bd\u03bf\u03c5\u03bd (\u03ad\u03c9\u03c2 20) \u03ba\u03b1\u03b9 \u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03bf\u03cd\u03bd \u03bf\u03b9 \u03a44 \u03ba\u03b1\u03b9 \u03a43. \u0393\u03b9\u03b1 \u03bd\u03b1 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03bf\u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b5\u03af \u03b1\u03c0\u03cc \u03c0\u03c1\u03bf\u03cb\u03c0\u03ac\u03c1\u03c7\u03bf\u03bd\u03c4\u03b1 \u03c5\u03c0\u03bf\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03c3\u03bc\u03cc \u03b8\u03b1 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03bb\u03b7\u03c6\u03b8\u03b5\u03af \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03bc\u03b5\u03c4\u03c1\u03ae\u03b8\u03bf\u03cd\u03bd \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7\u03c2 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae\u03c2 \u03c5\u03c0\u03b5\u03c1\u03bf\u03be\u03b5\u03b9\u03b4\u03ac\u03c3\u03b7\u03c2.<\/li>\n
  3. \u0391\u03c0\u03cc \u03c5\u03c0\u03bf\u03c6\u03c5\u03c3\u03b9\u03b1\u03ba\u03ae \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03c3\u03b5 \u03b2\u03b1\u03c1\u03ad\u03c9\u03c2 \u03c0\u03ac\u03c3\u03c7\u03bf\u03bd\u03c4\u03b5\u03c2 (\u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03bf\u03c5 \u03bd\u03bf\u03c3\u03b7\u03bb\u03b5\u03cd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u039c\u0395\u0398). \u03a3\u03c4\u03b7\u03bd \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03b1\u03c5\u03c4\u03ae \u03c4\u03b1 \u03c5\u03c8\u03b7\u03bb\u03ac \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03ba\u03bf\u03c1\u03c4\u03b9\u03b6\u03cc\u03bb\u03b7\u03c2 \u03b8\u03b1 \u03be\u03b5\u03c7\u03c9\u03c1\u03af\u03c3\u03bf\u03c5\u03bd \u03c4\u03bf \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03c5\u03c0\u03bf\u03c6\u03c5\u03c3\u03b9\u03b1\u03ba\u03ae \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03b5\u03ba\u03c4\u03cc\u03c2 \u03b5\u03ac\u03bd\u03ac\u03bd \u03c3\u03c5\u03bd\u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03bd\u03b5\u03c6\u03c1\u03b9\u03b4\u03b9\u03b1\u03ba\u03ae \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 (CIRCI)<\/li>\n<\/ol>\n

    6. \u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1<\/b><\/h4>\n

    \u0397 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b4\u03c1\u03cc\u03bc\u03bf\u03c5 \u039c\u0398\u039d \u03bc\u03b5 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ad\u03c2 \u03bf\u03c1\u03bc\u03cc\u03bd\u03b5\u03c2 \u03c3\u03b5 \u03c3\u03b5\u03b9\u03c1\u03ac \u03bc\u03b5\u03bb\u03b5\u03c4\u03ce\u03bd \u03b4\u03b5\u03bd \u03ad\u03b4\u03b5\u03b9\u03be\u03b5 \u03cc\u03c4\u03b9 \u03b2\u03b5\u03bb\u03c4\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03bd\u03bf\u03c3\u03b7\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b8\u03bd\u03b7\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1 (44). \u039c\u03cc\u03bd\u03bf \u03c3\u03b5 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03bc\u03b5\u03c4\u03b1\u03bc\u03cc\u03c3\u03c7\u03b5\u03c5\u03c3\u03b7\u03c2 \u03ba\u03b1\u03c1\u03b4\u03b9\u03ac\u03c2 \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03b1\u03c0\u03bf\u03b4\u03bf\u03c7\u03ae \u03c3\u03c4\u03b9\u03c2 \u0397\u03a0\u0391 (45) \u03c4\u03b7\u03c2 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7\u03c2 \u03a43 \u03cc\u03c4\u03b1\u03bd \u03c4\u03bf \u03ba\u03bb\u03ac\u03c3\u03bc\u03b1 \u03b5\u03be\u03ce\u03b8\u03b7\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03b4\u03cc\u03c4\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03ba\u03c1\u03cc\u03c4\u03b5\u03c1\u03bf \u03c4\u03bf\u03c5 45%. \u0394\u03b7\u03bc\u03b9\u03bf\u03c5\u03c1\u03b3\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b4\u03b9\u03ac\u03c6\u03bf\u03c1\u03b1 \u03b5\u03c1\u03c9\u03c4\u03ae\u03bc\u03b1\u03c4\u03b1 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5 \u03c4\u03bf \u03c0\u03bf\u03b9\u03ac \u03b8\u03b1 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b4\u03c1\u03cc\u03bc\u03bf\u03c5, \u03cc\u03c0\u03c9\u03c2 \u03c4\u03bf\u03c5 \u03b5\u03ac\u03bd \u03b8\u03b1 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03c7\u03bf\u03c1\u03b7\u03b3\u03b5\u03af \u03ba\u03b1\u03bd\u03b5\u03af\u03c2 \u03a44 \u03ae \u03ba\u03b1\u03b9 \u03a43 \u03ae \u03bc\u03cc\u03bd\u03bf \u03a43, \u03c3\u03b5 \u03c0\u03bf\u03b9\u03ac \u03c6\u03ac\u03c3\u03b7 \u03bf\u03be\u03b5\u03af\u03b1 \u03ae \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03c0\u03bf\u03b9\u03bf\u03cd\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2. \u0395\u03bd\u03b1\u03bb\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ae \u03c0\u03c1\u03bf\u03c3\u03ad\u03b3\u03b3\u03b9\u03c3\u03b7 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03b7 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03c5\u03c0\u03bf\u03b8\u03b1\u03bb\u03b1\u03bc\u03b9\u03ba\u03ce\u03bd \u03b5\u03ba\u03bb\u03c5\u03c4\u03b9\u03ba\u03ce\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03cc\u03bd\u03c4\u03c9\u03bd \u03c3\u03c4\u03b7 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03c6\u03ac\u03c3\u03b7 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c4\u03b7\u03c2 \u039c\u0395\u0398 \u03b1\u03c6\u03bf\u03cd \u03cc\u03c0\u03c9\u03c2 \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b8\u03b1 \u03b8\u03b5\u03c1\u03ac\u03c0\u03b5\u03c5\u03b5 \u03c4\u03b7\u03bd \u03b1\u03b9\u03c4\u03af\u03b1 \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b4\u03c1\u03cc\u03bc\u03bf\u03c5 \u03c3\u03b5 \u03b1\u03c5\u03c4\u03bf\u03cd\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2. \u03a3\u03b5 \u03bc\u03b9\u03b1 \u03b5\u03c1\u03b3\u03b1\u03c3\u03af\u03b1 \u03c3\u03b5 33 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c4\u03b7\u03c2 \u039c\u0395\u0398 \u03c7\u03bf\u03c1\u03b7\u03b3\u03ae\u03b8\u03b7\u03ba\u03b1\u03bd \u03c3\u03b5 \u03c3\u03c5\u03bd\u03b5\u03c7\u03ae \u03b5\u03bd\u03b4\u03bf\u03c6\u03bb\u03ad\u03b2\u03b9\u03b1 \u03ad\u03b3\u03c7\u03c5\u03c3\u03b7 \u03b3\u03b9\u03b1 5 \u03b7\u03bc\u03ad\u03c1\u03b5\u03c2 TRH, GHRP-2 \u03ba\u03b1\u03b9 \u03ba\u03b1\u03c4\u03ac \u03ce\u03c3\u03b5\u03b9\u03c2 GnRH \u03b1\u03c5\u03be\u03ae\u03b8\u03b7\u03ba\u03b1\u03bd \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03c9\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03bf\u03c1\u03bc\u03bf\u03bd\u03ce\u03bd, \u03c4\u03c9\u03bd \u03c3\u03c4\u03b5\u03c1\u03bf\u03b5\u03b9\u03b4\u03ce\u03bd \u03c4\u03bf\u03c5 \u03c6\u03cd\u03bb\u03bf\u03c5, \u03ba\u03b1\u03b9 IGF-I \u03b5\u03bd\u03ce \u03b2\u03b5\u03bb\u03c4\u03b9\u03ce\u03b8\u03b7\u03ba\u03b1\u03bd \u03b1\u03bd\u03b1\u03b2\u03bf\u03bb\u03b9\u03ba\u03bf\u03af \u03b4\u03b5\u03af\u03ba\u03c4\u03b5\u03c2 (18). \u03a3\u03c4\u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03cc\u03bc\u03c9\u03c2 \u03b1\u03c5\u03c4\u03ae \u03b4\u03b5\u03bd \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03b8\u03b7\u03ba\u03b5 \u03b7 \u03bd\u03bf\u03c3\u03b7\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03b7 \u03b8\u03bd\u03b7\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1.<\/p>\n

    \u0392\u03b9\u03b2\u03bb\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1<\/h4>\n

    1. Oppenheimer JH, Squef R, Surks MI, et al. Binding of Thyroxine by Serum Proteins Evaluated by Equilibrum Dialysis and Electrophoretic Techniques. Alterations in Nonthyroidal Illness. The Journal of clinical investigation. 1963; 42:1769-1782.
    \n2. De Groot LJ. Dangerous dogmas in medicine: the nonthyroidal illness syndrome. The Journal of clinical endocrinology and metabolism. 1999; 84:151-164.
    \n3. Pappa TA, Vagenakis AG, Alevizaki M. The nonthyroidal illness syndrome in the non-critically ill patient. European journal of clinical investigation. 2011; 41:212-220.
    \n4. Warner MH, Beckett GJ. Mechanisms behind the non-thyroidal illness syndrome: an update. The Journal of endocrinology. 2010; 205:1-13.
    \n5. Vagenakis AG, Burger A, Portnary GI, et al. Diversion of peripheral thyroxine metabolism from activating to inactivating pathways during complete fasting. The Journal of clinical endocrinology and metabolism. 1975; 41:191-194.
    \n6. Madeddu G, Spanu A, Chessa F, et al. Thyroid function in human immunodeficiency virus patients treated with highly active antiretroviral therapy (HAART): a longitudinal study. Clinical endocrinology. 2006; 64:375-383.
    \n7. Van den Berghe G, de Zegher F, Bouillon R. Clinical review 95: Acute and prolonged critical illness as different neuroendocrine paradigms. The Journal of clinical endocrinology and metabolism. 1998; 83:1827-1834.
    \n8. Wartofsky L, Burman KD. Alterations in thyroid function in patients with systemic illness: the “euthyroid sick syndrome”. Endocrine reviews. 1982; 3:164-217.
    \n9. Michalaki M, Vagenakis AG, Makri M, et al. Dissociation of the early decline in serum T(3) concentration and serum IL-6 rise and TNFalpha in nonthyroidal illness syndrome induced by abdominal surgery. The Journal of clinical endocrinology and metabolism. 2001; 86:4198-4205.
    \n10. Bartalena L, Martino E, Brandi LS, et al. Lack of nocturnal serum thyrotropin surge after surgery. The Journal of clinical endocrinology and metabolism. 1990; 70:293-296.
    \n11. Van den Berghe G, de Zegher F, Veldhuis JD, et al. Thyrotrophin and prolactin release in prolonged critical illness: dynamics of spontaneous secretion and effects of growth hormone-secretagogues. Clinical endocrinology. 1997; 47:599-612.
    \n12. Mebis L, Van den Berghe G. Thyroid axis function and dysfunction in critical illness. Best practice & research Clinical endocrinology & metabolism. 2011; 25:745-757.
    \n13. Lester R 2001 Thyroid physiology : synthesis and release, iodine metabolism, binding and transport. In: Bekker k, (ed) Principles and Practice of Endocrinology and Metabolism. 3rd ed. Vol. Lippincott Williams & Wilkins, Philadelphia, 314-321.
    \n14. Farwell AP. Nonthyroidal illness syndrome. Current opinion in endocrinology, diabetes, and obesity. 2013; 20:478-484.
    \n15. Wilcox RB, Nelson JC, Tomei RT. Heterogeneity in affinities of serum proteins for thyroxine among patients with non-thyroidal illness as indicated by the serum free thyroxine response to serum dilution. European journal of endocrinology \/ European Federation of Endocrine Societies. 1994; 131:9-13.
    \n16. Van den Berghe G, de Zegher F, Baxter RC, et al. Neuroendocrinology of prolonged critical illness: effects of exogenous thyrotropin-releasing hormone and its combination with growth hormone secretagogues. The Journal of clinical endocrinology and metabolism. 1998; 83:309-319.
    \n17. Van den Berghe G, Wouters P, Weekers F, et al. Reactivation of pituitary hormone release and metabolic improvement by infusion of growth hormone-releasing peptide and thyrotropin-releasing hormone in patients with protracted critical illness. The Journal of clinical endocrinology and metabolism. 1999; 84:1311-1323.
    \n18. Van den Berghe G, Baxter RC, Weekers F, et al. The combined administration of GH-releasing peptide-2 (GHRP-2), TRH and GnRH to men with prolonged critical illness evokes superior endocrine and metabolic effects compared to treatment with GHRP-2 alone. Clinical endocrinology. 2002; 56:655-669.
    \n19. Fliers E, Guldenaar SE, Wiersinga WM, et al. Decreased hypothalamic thyrotropin-releasing hormone gene expression in patients with nonthyroidal illness. The Journal of clinical endocrinology and metabolism. 1997; 82:4032-4036.
    \n20. Fekete C, Lechan RM. Negative feedback regulation of hypophysiotropic thyrotropin-releasing hormone (TRH) synthesizing neurons: role of neuronal afferents and type 2 deiodinase. Frontiers in neuroendocrinology. 2007; 28:97-114.
    \n21. Chan JL, Heist K, DePaoli AM, et al. The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men. The Journal of clinical investigation. 2003; 111:1409-1421.
    \n22. Ahima RS, Prabakaran D, Mantzoros C, et al. Role of leptin in the neuroendocrine response to fasting. Nature. 1996; 382:250-252.
    \n23. Boelen A, Kwakkel J, Thijssen-Timmer DC, et al. Simultaneous changes in central and peripheral components of the hypothalamus-pituitary-thyroid axis in lipopolysaccharide-induced acute illness in mice. The Journal of endocrinology. 2004; 182:315-323.
    \n24. Reed L 2001 Thyroid Physiology: synthesis and Release, Iodine Metabolism, Binding and Transport. In: Bekker k, (ed) Principles and Practice of Endocrinology and Metabolism. 3rd ed. Vol. Lippincott Williams & Wilkins, Philadelphia, 314-321.
    \n25. Tibaldi JM, Surks MI. Animal models of nonthyroidal disease. Endocrine reviews. 1985; 6:87-102.
    \n26. Zeold A, Pormuller L, Dentice M, et al. Metabolic instability of type 2 deiodinase is transferable to stable proteins independently of subcellular localization. The Journal of biological chemistry. 2006; 281:31538-31543.
    \n27. LoPresti JS, Eigen A, Kaptein E, et al. Alterations in 3,3’5′-triiodothyronine metabolism in response to propylthiouracil, dexamethasone, and thyroxine administration in man. The Journal of clinical investigation. 1989; 84:1650-1656.
    \n28. Maia AL, Kim BW, Huang SA, et al. Type 2 iodothyronine deiodinase is the major source of plasma T3 in euthyroid humans. The Journal of clinical investigation. 2005; 115:2524-2533.
    \n29. Larsen PR. Type 2 iodothyronine deiodinase in human skeletal muscle: new insights into its physiological role and regulation. The Journal of clinical endocrinology and metabolism. 2009; 94:1893-1895.
    \n30. Heemstra KA, Soeters MR, Fliers E, et al. Type 2 iodothyronine deiodinase in skeletal muscle: effects of hypothyroidism and fasting. The Journal of clinical endocrinology and metabolism. 2009; 94:2144-2150.
    \n31. Wajner SM, Maia AL. New Insights toward the Acute Non-Thyroidal Illness Syndrome. Frontiers in endocrinology. 2012; 3:8.
    \n32. Yu J, Koenig RJ. Regulation of hepatocyte thyroxine 5′-deiodinase by T3 and nuclear receptor coactivators as a model of the sick euthyroid syndrome. The Journal of biological chemistry. 2000; 275:38296-38301.
    \n33. Ogiwara T, Araki O, Morimura T, et al. A novel mechanism for the inhibition of type 2 iodothyronine deiodinase by tumor necrosis factor alpha: involvement of proteasomal degradation. Endocrine journal. 2013; 60:1035-1045.
    \n34. St Germain DL, Galton VA, Hernandez A. Minireview: Defining the roles of the iodothyronine deiodinases: current concepts and challenges. Endocrinology. 2009; 150:1097-1107.
    \n35. Kwakkel J, Chassande O, van Beeren HC, et al. Lacking thyroid hormone receptor beta gene does not influence alterations in peripheral thyroid hormone metabolism during acute illness. The Journal of endocrinology. 2008; 197:151-158.
    \n36. Rodriguez-Perez A, Palos-Paz F, Kaptein E, et al. Identification of molecular mechanisms related to nonthyroidal illness syndrome in skeletal muscle and adipose tissue from patients with septic shock. Clinical endocrinology. 2008; 68:821-827.
    \n37. Peeters RP, Wouters PJ, Kaptein E, et al. Reduced activation and increased inactivation of thyroid hormone in tissues of critically ill patients. The Journal of clinical endocrinology and metabolism. 2003; 88:3202-3211.
    \n38. Mebis L, Langouche L, Visser TJ, et al. The type II iodothyronine deiodinase is up-regulated in skeletal muscle during prolonged critical illness. The Journal of clinical endocrinology and metabolism. 2007; 92:3330-3333.
    \n39. Boelen A, Kwakkel J, Fliers E. Beyond low plasma T3: local thyroid hormone metabolism during inflammation and infection. Endocrine reviews. 2011; 32:670-693.
    \n40. Wajner SM, Goemann IM, Bueno AL, et al. IL-6 promotes nonthyroidal illness syndrome by blocking thyroxine activation while promoting thyroid hormone inactivation in human cells. The Journal of clinical investigation. 2011; 121:1834-1845.
    \n41. Peeters RP, van der Geyten S, Wouters PJ, et al. Tissue thyroid hormone levels in critical illness. The Journal of clinical endocrinology and metabolism. 2005; 90:6498-6507.
    \n42. Thijssen-Timmer DC, Peeters RP, Wouters P, et al. Thyroid hormone receptor isoform expression in livers of critically ill patients. Thyroid : official journal of the American Thyroid Association. 2007; 17:105-112.
    \n43. Franklyn JA, Black EG, Betteridge J, et al. Comparison of second and third generation methods for measurement of serum thyrotropin in patients with overt hyperthyroidism, patients receiving thyroxine therapy, and those with nonthyroidal illness. The Journal of clinical endocrinology and metabolism. 1994; 78:1368-1371.
    \n44. Brent GA, Hershman JM. Thyroxine therapy in patients with severe nonthyroidal illnesses and low serum thyroxine concentration. The Journal of clinical endocrinology and metabolism. 1986; 63:1-8.
    \n45. Zaroff JG, Rosengard BR, Armstrong WF, et al. Consensus conference report: maximizing use of organs recovered from the cadaver donor: cardiac recommendations, March 28-29, 2001, Crystal City, Va. Circulation. 2002; 106:836-841.<\/p>\n

    \n

    Created: October 27, 2014
    \nLast update: October 27, 2014<\/p>\n","protected":false},"excerpt":{"rendered":"

    \u039c. \u039c\u03b9\u03c7\u03b1\u03bb\u03ac\u03ba\u03b7 \u0395\u03c0\u03b9\u03bc\u03b5\u03bb\u03ae\u03c4\u03c1\u03b9\u03b1 \u0391\u2019, \u0395\u03bd\u03b4\u03bf\u03ba\u03c1\u03b9\u03bd\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03a4\u03bc\u03ae\u03bc\u03b1, \u03a0\u03b1\u03bd\u03b5\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03b9\u03b1\u03ba\u03ae \u03a0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae, \u03a0\u03b1\u03bd\u03b5\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03b9\u03b1\u03ba\u03cc \u0393\u03b5\u03bd\u03b9\u03ba\u03cc \u039d\u03bf\u03c3\u03bf\u03ba\u03bf\u03bc\u03b5\u03af\u03bf \u03a0\u03b1\u03c4\u03c1\u03ce\u03bd \u0391.\u0393. \u0392\u03b1\u03b3\u03b5\u03bd\u03ac\u03ba\u03b7\u03c2 \u039f\u03bc\u03cc\u03c4\u03b9\u03bc\u03bf\u03c2 \u039a\u03b1\u03b8\u03b7\u03b3\u03b7\u03c4\u03ae\u03c2 \u0395\u03bd\u03b4\u03bf\u03ba\u03c1\u03b9\u03bd\u03bf\u03bb\u03bf\u03b3\u03af\u03b1\u03c2-\u03a0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03af\u03b1\u03c2, \u03a0\u03b1\u03bd\u03b5\u03c0\u03b9\u03c3\u03c4\u03ae\u03bc\u03b9\u03bf \u03a0\u03b1\u03c4\u03c1\u03ce\u03bd \u00a01. \u039f\u03c1\u03b9\u03c3\u03bc\u03cc\u03c2 \u2013 \u039a\u03b1\u03c4\u03b1\u03c3\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c3\u03c4\u03b9\u03c2 \u03bf\u03c0\u03bf\u03af\u03b5\u03c2 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03a4\u03bf \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf \u03c4\u03b7\u03c2 \u03bc\u03b7 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5 (\u039c\u0398\u039d) \u03c0\u03b5\u03c1\u03b9\u03b5\u03b3\u03c1\u03ac\u03c6\u03b5\u03b9 \u03b3\u03b9\u03b1 \u03c0\u03c1\u03ce\u03c4\u03b7 \u03c6\u03bf\u03c1\u03ac \u03c4\u03bf 1963 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd Oppenheimer (1) \u03ba\u03b1\u03b9 \u03b1\u03c6\u03bf\u03c1\u03ac \u03c4\u03b9\u03c2 \u03c0\u03b1\u03c1\u03bf\u03b4\u03b9\u03ba\u03ad\u03c2 \u03b1\u03bb\u03bb\u03b1\u03b3\u03ad\u03c2 \u03c4\u03c9\u03bd \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03c4\u03c1\u03c9\u03bd \u03c4\u03b7\u03c2 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2 \u03bf\u03b9 […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"pageCustom.php","meta":{"footnotes":""},"tags":[],"_links":{"self":[{"href":"https:\/\/e-endocrinology.gr\/index.php?rest_route=\/wp\/v2\/pages\/826"}],"collection":[{"href":"https:\/\/e-endocrinology.gr\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/e-endocrinology.gr\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/e-endocrinology.gr\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/e-endocrinology.gr\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=826"}],"version-history":[{"count":4,"href":"https:\/\/e-endocrinology.gr\/index.php?rest_route=\/wp\/v2\/pages\/826\/revisions"}],"predecessor-version":[{"id":838,"href":"https:\/\/e-endocrinology.gr\/index.php?rest_route=\/wp\/v2\/pages\/826\/revisions\/838"}],"wp:attachment":[{"href":"https:\/\/e-endocrinology.gr\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=826"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/e-endocrinology.gr\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=826"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}