{"id":674,"date":"2014-10-22T11:05:17","date_gmt":"2014-10-22T08:05:17","guid":{"rendered":"http:\/\/e-endocrinology.gr\/?page_id=674"},"modified":"2015-02-18T15:06:00","modified_gmt":"2015-02-18T12:06:00","slug":"10-10-%cf%80%ce%b1%ce%b8%ce%bf%ce%b3%ce%ad%ce%bd%ce%b5%ce%b9%ce%b1-%ce%b1%cf%85%cf%84%ce%bf%ce%ac%ce%bd%ce%bf%cf%83%ce%b7%cf%82-%ce%b8%cf%85%cf%81%ce%b5%ce%bf%ce%b5%ce%b9%ce%b4%ce%b9%ce%ba%ce%ae%cf%82","status":"publish","type":"page","link":"https:\/\/e-endocrinology.gr\/?page_id=674","title":{"rendered":"10.10 \u03a0\u03b1\u03b8\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1 \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03b7\u03c2 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5"},"content":{"rendered":"

\n \n \"Print\n <\/a>\n <\/div><\/p>\n

 <\/p>\n

\u03a3\u03c4\u03ad\u03bb\u03b9\u03bf\u03c2 \u03a6\u03bf\u03c5\u03bd\u03c4\u03bf\u03c5\u03bb\u03ac\u03ba\u03b7\u03c2<\/em>
\n\u0395\u03b9\u03b4\u03b9\u03ba\u03b5\u03c5\u03cc\u03bc\u03b5\u03bd\u03bf\u03c2 \u0395\u03bd\u03b4\u03bf\u03ba\u03c1\u03b9\u03bd\u03bf\u03bb\u03cc\u03b3\u03bf\u03c2, \u0394\u03b9\u03b4\u03ac\u03ba\u03c4\u03c9\u03c1 \u03a0\u03b1\u03bd\u03b5\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03af\u03bf\u03c5 \u0399\u03c9\u03b1\u03bd\u03bd\u03af\u03bd\u03c9\u03bd,
\n\u0395\u03bd\u03b4\u03bf\u03ba\u03c1\u03b9\u03bd\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03ba\u03b1\u03b9 \u0394\u03b9\u03b1\u03b2\u03b7\u03c4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u039a\u03ad\u03bd\u03c4\u03c1\u03bf \u0393.\u039d.\u0391 \u00ab\u0393. \u0393\u03b5\u03bd\u03bd\u03b7\u03bc\u03b1\u03c4\u03ac\u03c2\u00bb,
\n\u0391\u03b3\u03b1\u03b8\u03bf\u03ba\u03bb\u03ae\u03c2 \u03a4\u03c3\u03b1\u03c4\u03c3\u03bf\u03cd\u03bb\u03b7\u03c2
\n<\/b><\/em>\u039a\u03b1\u03b8\u03b7\u03b3\u03b7\u03c4\u03ae\u03c2 \u0395\u03bd\u03b4\u03bf\u03ba\u03c1\u03b9\u03bd\u03bf\u03bb\u03bf\u03b3\u03af\u03b1\u03c2-\u03a0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03af\u03b1\u03c2, \u0394\u03b9\u03b5\u03c5\u03b8\u03c5\u03bd\u03c4\u03ae\u03c2 \u0395\u03bd\u03b4\u03bf\u03ba\u03c1\u03b9\u03bd\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae\u03c2
\n\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae\u03c2 \u2013\u0394\u03b9\u03b1\u03b2\u03b7\u03c4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03bf\u03cd \u039a\u03ad\u03bd\u03c4\u03c1\u03bf\u03c5 \u03a0\u03b1\u03bd\u03b5\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03b9\u03b1\u03ba\u03bf\u03cd \u039d\u03bf\u03c3\u03bf\u03ba\u03bf\u03bc\u03b5\u03af\u03bf\u03c5 \u0399\u03c9\u03b1\u03bd\u03bd\u03af\u03bd\u03c9\u03bd<\/p>\n

\u0395\u03b9\u03c3\u03b1\u03b3\u03c9\u03b3\u03ae<\/b><\/h4>\n

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\u03c0\u03b1\u03c1\u03b1\u03b3\u03cc\u03bd\u03c4\u03c9\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03b7 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ce\u03bd \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03ce\u03bd \u03c0\u03bf\u03c5 \u03b1\u03c1\u03c7\u03b9\u03ba\u03ac \u03bf\u03b4\u03b7\u03b3\u03bf\u03cd\u03bd \u03c3\u03c4\u03b7 \u03b4\u03b9\u03b1\u03c6\u03c5\u03b3\u03ae \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c4\u03b7\u03c2 \u03bb\u03b5\u03c5\u03ba\u03ae\u03c2 \u03c3\u03b5\u03b9\u03c1\u03ac\u03c2 (\u03c5\u03c0\u03bf\u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b5\u03c2 \u03a4 \u03ba\u03b1\u03b9 \u0392 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd) \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5\u03c2 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03cd\u03c2 \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03bf\u03c7\u03ae\u03c2 \u03ba\u03b1\u03b9 \u03ad\u03c0\u03b5\u03b9\u03c4\u03b1 \u03c3\u03c4\u03b7\u03bd \u03b5\u03af\u03c3\u03bf\u03b4\u03bf \u03c3\u03c4\u03bf \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03ae \u03cc\u03c0\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03b9\u03b4\u03c1\u03bf\u03cd\u03bd \u03bc\u03b5 \u03c4\u03b1 \u03b8\u03c5\u03c1\u03b5\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1. \u03a3\u03c4\u03b7\u03bd \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u0397\u03a4 \u03ba\u03b1\u03b9 \u03c4\u03c9\u03bd \u03c0\u03b1\u03c1\u03b1\u03bb\u03bb\u03b1\u03b3\u03ce\u03bd \u03c4\u03b7\u03c2, \u03b7 \u03b4\u03b9\u03b1\u03c4\u03ac\u03c1\u03b1\u03be\u03b7 \u03c4\u03b7\u03c2 \u03b9\u03c3\u03bf\u03c1\u03c1\u03bf\u03c0\u03af\u03b1\u03c2 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03b8\u03c5\u03c1\u03b5\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03ba\u03b1\u03b9 \u03b5\u03bd\u03b4\u03bf\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd, \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03b5 \u03b4\u03b9\u03ae\u03b8\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03bf\u03cd\u03c2 \u03b1\u03c0\u03cc \u03a4h1\/Th17 <\/b>\u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1, \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7 anti-TPO \/ anti-Tg \u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd, \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03c1\u03bf\u03c6\u03ae \u03c4\u03bf\u03c5 \u03b8\u03c5\u03c1\u03b5\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03c5\u03c0\u03bf\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03c3\u03bc\u03cc, \u03b5\u03bd\u03ce \u03c3\u03c4\u03b7\u03bd GD \u03c3\u03b5 \u03b4\u03b9\u03ae\u03b8\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03bf\u03cd\u03c2 \u03b1\u03c0\u03cc \u03a4h2 (\u03ba\u03b1\u03b9 \u03bb\u03b9\u03b3\u03cc\u03c4\u03b5\u03c1\u03bf Th1) <\/b>\u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1, \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae anti-TPO \/ anti-Tg \u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03ba\u03b1\u03b9 \u03b4\u03b9\u03b5\u03b3\u03b5\u03c1\u03c4\u03b9\u03ba\u03ce\u03bd \u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03c4\u03bf\u03c5 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03c4\u03b7\u03c2 TSH (thyroid stimulating antibodies\/\u03a4SAb) \u03bc\u03b5 \u03b5\u03c0\u03b1\u03ba\u03cc\u03bb\u03bf\u03c5\u03b8\u03bf \u03c5\u03c0\u03b5\u03c1\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03c3\u03bc\u03cc (2). \u0386\u03bb\u03bb\u03b1 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03c0\u03bf\u03c5 \u03b1\u03bd\u03b9\u03c7\u03bd\u03b5\u03cd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u0398\u0391 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c5\u03c4\u03ac \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03b1\u03c6\u03bf\u03c1\u03ad\u03b1 \u03bd\u03b1\u03c4\u03c1\u03af\u03bf\u03c5-\u03b9\u03c9\u03b4\u03af\u03bf\u03c5 (NIS) o \u03bf\u03c0\u03bf\u03af\u03bf\u03c2 \u03b5\u03b4\u03c1\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03b2\u03b1\u03c3\u03b9\u03ba\u03bf\u03c0\u03bb\u03ac\u03b3\u03b9\u03b1 (basolateral) \u03c0\u03bb\u03b5\u03c5\u03c1\u03ac \u03c4\u03c9\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c4\u03bf\u03c5 \u03b8\u03c5\u03bb\u03b1\u03ba\u03af\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03c4\u03b7\u03c2 pendrin \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c3\u03c5\u03bd\u03c4\u03b5\u03bb\u03b5\u03af \u03c3\u03c4\u03b7\u03bd \u03b5\u03bd\u03b4\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03b9\u03b1 \u03bc\u03b5\u03c4\u03b1\u03c6\u03bf\u03c1\u03ac \u03c4\u03bf\u03c5 \u03b9\u03c9\u03b4\u03af\u03bf\u03c5 \u03c0\u03c1\u03bf\u03c2 \u03c4\u03b7\u03bd \u03ba\u03bf\u03c1\u03c5\u03c6\u03b1\u03af\u03b1 (apical) \u03c0\u03bb\u03b5\u03c5\u03c1\u03ac \u03c4\u03bf\u03c5 \u03b8\u03c5\u03c1\u03b5\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03bf\u03c5 (10% \u03c3\u03c4\u03b7\u03bd GD \u03ba\u03b1\u03b9 8% \u03c3\u03c4\u03b7\u03bd HT \u03c3\u03b5 \u03c3\u03b5\u03b9\u03c1\u03ac \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03c3\u03c4\u03b7 \u039c. \u0392\u03c1\u03b5\u03c4\u03b1\u03bd\u03af\u03b1) (3).<\/p>\n

\u039f\u03b9 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03b5\u03c1\u03b5\u03c5\u03bd\u03bf\u03cd\u03bd \u03c4\u03b9\u03c2 \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03b5\u03c2 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ad\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5\u03c2 \u03b5\u03c3\u03c4\u03b9\u03ac\u03b6\u03bf\u03c5\u03bd \u03c3\u03c4\u03bf\u03bd \u03ba\u03b1\u03b8\u03bf\u03c1\u03b9\u03c3\u03bc\u03cc \u03c4\u03b7\u03c2 \u03b1\u03b9\u03c4\u03b9\u03bf\u03c0\u03b1\u03b8\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03ac\u03c2 \u03c4\u03bf\u03c5\u03c2, \u03bc\u03b5 \u03c3\u03ba\u03bf\u03c0\u03cc \u03c4\u03b7\u03bd \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 \u03b1\u03b9\u03c4\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ce\u03bd \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ce\u03bd \u03bc\u03ad\u03c3\u03c9\u03bd \u03c3\u03c4\u03b7 \u03b8\u03ad\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c3\u03c5\u03bc\u03c0\u03c4\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03ce\u03bd \u03c0\u03bf\u03c5 \u03b5\u03c6\u03b1\u03c1\u03bc\u03cc\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03ae\u03bc\u03b5\u03c1\u03b1. \u03a3\u03c4\u03bf \u03ba\u03b5\u03c6\u03ac\u03bb\u03b1\u03b9\u03bf \u03b1\u03c5\u03c4\u03cc \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03bd\u03b1\u03c6\u03bf\u03c1\u03ac \u03c3\u03c4\u03b9\u03c2 \u03bd\u03b5\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03b5\u03be\u03b5\u03bb\u03af\u03be\u03b5\u03b9\u03c2 \u03c0\u03bf\u03c5 \u03b1\u03c6\u03bf\u03c1\u03bf\u03cd\u03bd \u03c3\u03c4\u03bf\u03c5\u03c2 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03cd\u03c2 \u03bf\u03b9 \u03bf\u03c0\u03bf\u03af\u03bf\u03b9 \u03b5\u03bc\u03c0\u03bb\u03ad\u03ba\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b1\u03b9\u03c4\u03b9\u03bf\u03c0\u03b1\u03b8\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 \u0398\u0391.<\/p>\n

1. \u039a\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03b9\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae\u03c2 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03bf\u03c3\u03af\u03b1\u03c2<\/b><\/h4>\n

\u0397 \u03c4\u03b1\u03be\u03b9\u03bd\u03cc\u03bc\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u0398\u0391 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03b9 \u03c4\u03bf\u03c5\u03c2 \u03b4\u03b9\u03ac\u03c6\u03bf\u03c1\u03bf\u03c5\u03c2 \u03c4\u03cd\u03c0\u03bf\u03c5\u03c2 \u03c4\u03b7\u03c2 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1\u03c2 \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03b7\u03c2 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03af\u03c4\u03b9\u03b4\u03b1\u03c2 (\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03af\u03c4\u03b9\u03b4\u03b1 Hashimoto-HT) \u03ba\u03b1\u03b9 \u03c4\u03b7 GD.<\/p>\n

    \n
  1. \u00a0\u0397 \u0397\u03a4 \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 \u03b2\u03c1\u03bf\u03b3\u03c7\u03bf\u03ba\u03ae\u03bb\u03b7\u03c2, \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd (\u03ba\u03c5\u03c1\u03af\u03c9\u03c2 anti-TPO \u03ba\u03b1\u03b9 anti-Tg) \u03ba\u03b1\u03b9 \u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2 \u03c4\u03bf\u03c5 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03bf\u03cd\u03c2. \u0398\u03b5\u03c9\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03c1\u03bf\u03c6\u03ae\u03c2 \u03c4\u03c9\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03b1\u03c0\u03cc \u03ac\u03c6\u03b8\u03bf\u03bd\u03b1 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03a4 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 (T effector cells) \u03c0\u03bf\u03c5 \u03b4\u03b9\u03b7\u03b8\u03bf\u03cd\u03bd \u03c4\u03bf \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03ae \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03bf\u03c0\u03bf\u03af\u03b1 \u03bc\u03ad\u03c7\u03c1\u03b9 \u03c0\u03c1\u03cc\u03c3\u03c6\u03b1\u03c4\u03b1 \u03b8\u03b5\u03c9\u03c1\u03bf\u03cd\u03bd\u03c4\u03b1\u03bd \u03c4\u03bf\u03c5 Th1 \u03c4\u03cd\u03c0\u03bf\u03c5, \u03c9\u03c2 \u03b5\u03c0\u03af \u03c4\u03bf \u03c0\u03bb\u03b5\u03af\u03c3\u03c4\u03bf\u03bd (4). \u039d\u03b5\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b4\u03b5\u03af\u03be\u03b5\u03b9 \u03c0\u03c9\u03c2 \u03b5\u03bc\u03c0\u03bb\u03ad\u03ba\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c4\u03cc\u03c3\u03bf \u03a4h2 \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03a4h17 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1, \u03bf \u03c1\u03cc\u03bb\u03bf\u03c2 \u03c4\u03c9\u03bd \u03bf\u03c0\u03bf\u03af\u03c9\u03bd \u03c0\u03c1\u03bf\u03c3\u03c6\u03ac\u03c4\u03c9\u03c2 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03b5 \u03b1\u03bd\u03c4\u03b9\u03ba\u03b5\u03af\u03bc\u03b5\u03bd\u03bf \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1\u03c2 (5). \u03a4\u03bf \u03c4\u03b5\u03bb\u03b9\u03ba\u03cc \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf \u03c5\u03c0\u03bf\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03c3\u03bc\u03cc\u03c2.<\/li>\n
  2. \u03a3\u03c4\u03b1 \u03b1\u03c1\u03c7\u03b9\u03ba\u03ac \u03c3\u03c4\u03ac\u03b4\u03b9\u03b1 \u03b7 \u0397\u03a4 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c9\u03c2 \u03c5\u03c0\u03bf\u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc\u03c2 \u03c5\u03c0\u03bf\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03c3\u03bc\u03cc\u03c2, \u03bf \u03bf\u03c0\u03bf\u03af\u03bf\u03c2 \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c0\u03c9\u03c2 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03c4\u03bf \u03b1\u03c1\u03c7\u03b9\u03ba\u03cc \u03c3\u03c4\u03ac\u03b4\u03b9\u03bf \u03c4\u03b7\u03c2 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03af\u03c4\u03b9\u03b4\u03b1\u03c2 Hashimoto \u03b1\u03bb\u03bb\u03ac \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03c3\u03b9\u03c9\u03c0\u03b7\u03bb\u03ae \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03af\u03c4\u03b9\u03b4\u03b1. \u0395\u03af\u03bd\u03b1\u03b9 \u03c0\u03b9\u03bf \u03c3\u03c5\u03c7\u03bd\u03ac \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03b7\u03c2 \u03b1\u03b9\u03c4\u03b9\u03bf\u03bb\u03bf\u03b3\u03af\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc \u03c4\u03af\u03c4\u03bb\u03bf \u03b1\u03bd\u03c4\u03b9\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd, \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03c4\u03b9\u03bc\u03ad\u03c2 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03bf\u03c1\u03bc\u03bf\u03bd\u03ce\u03bd \u03ba\u03b1\u03b9 \u03bf\u03c1\u03b9\u03b1\u03ba\u03ac \u03c5\u03c8\u03b7\u03bb\u03ac \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 TSH (>5 \u03bcU\/ml). \u03a3\u03b5 \u03bd\u03b5\u03b1\u03c1\u03ac \u03ac\u03c4\u03bf\u03bc\u03b1, \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03b7\u03c2 TSH \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b1 \u03b1\u03c0\u03cc 3,5 \u03bcU\/ml, \u03b8\u03b5\u03c9\u03c1\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac. \u0391\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf \u03c4\u03af\u03c4\u03bb\u03bf \u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c5\u03c0\u03bf\u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03c5\u03c0\u03bf\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03c3\u03bc\u03cc \u03b5\u03be\u03b5\u03bb\u03af\u03c3\u03c3\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03c5\u03c0\u03bf\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u0397\u03a4 \u03bc\u03b5 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 5% \u03b1\u03bd\u03ac \u03ad\u03c4\u03bf\u03c2. \u039f \u03b5\u03c0\u03b9\u03c0\u03bf\u03bb\u03b1\u03c3\u03bc\u03cc\u03c2 \u03c4\u03bf\u03c5 \u03c5\u03c0\u03bf\u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03bf\u03cd \u03c5\u03c0\u03bf\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03c3\u03bc\u03bf\u03cd \u03b5\u03af\u03bd\u03b1\u03b9 7,5-8,5% \u03c3\u03c4\u03b9\u03c2 \u03b3\u03c5\u03bd\u03b1\u03af\u03ba\u03b5\u03c2 \u03ba\u03b1\u03b9 3-4,4% \u03c3\u03c4\u03bf\u03c5\u03c2 \u03ac\u03bd\u03b4\u03c1\u03b5\u03c2 \u03b5\u03bd\u03ce \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b7\u03bb\u03b9\u03ba\u03af\u03b1, \u03c0\u03c1\u03bf\u03c3\u03b5\u03b3\u03b3\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03bf 17 % \u03c3\u03b5 \u03b7\u03bb\u03b9\u03ba\u03af\u03b5\u03c2 \u03ac\u03bd\u03c9 \u03c4\u03c9\u03bd 60 \u03b5\u03c4\u03ce\u03bd. \u03a3\u03c4\u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 NHANES III \u03b7 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03ae\u03c2 \u03c4\u03bf\u03c5 \u03ae\u03c4\u03b1\u03bd 5,8% \u03c3\u03b5 \u03b3\u03c5\u03bd\u03b1\u03af\u03ba\u03b5\u03c2 \u03ba\u03b1\u03b9 3,4% \u03c3\u03b5 \u03ac\u03bd\u03b4\u03c1\u03b5\u03c2 \u03ac\u03bd\u03c9 \u03c4\u03c9\u03bd 12 \u03b5\u03c4\u03ce\u03bd \u03b5\u03bd\u03ce \u03c3\u03c4\u03b7 Whickman \u03ae\u03c4\u03b1\u03bd 4-5% \u03c3\u03b5 \u03b3\u03c5\u03bd\u03b1\u03af\u03ba\u03b5\u03c2 18-44 \u03b5\u03c4\u03ce\u03bd \u03ba\u03b1\u03b9 17,4% \u03c3\u03b5 \u03ac\u03bd\u03c9 \u03c4\u03c9\u03bd 70 (6,7).<\/li>\n
  3. \u03a5\u03c0\u03bf\u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b1 \u03c4\u03b7\u03c2 \u0397\u03a4 \u03b8\u03b5\u03c9\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03b7 \u03c3\u03c0\u03ac\u03bd\u03b9\u03b1 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03af\u03c4\u03b9\u03b4\u03b1 Riedel (Riedel struma), \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03b1\u03bd\u03c4\u03b9\u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03bf\u03cd \u03b9\u03c3\u03c4\u03bf\u03cd \u03b1\u03c0\u03cc \u03b9\u03bd\u03ce\u03b4\u03b7. \u0397 \u03af\u03bd\u03c9\u03c3\u03b7 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03ba\u03c4\u03b5\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03c0\u03ad\u03c1\u03b1\u03bd \u03c4\u03bf\u03c5 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03bf\u03cd\u03c2 \u03bc\u03b5 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03bf\u03c7\u03ae \u03c4\u03c9\u03bd \u03c0\u03b1\u03c1\u03b1\u03ba\u03b5\u03af\u03bc\u03b5\u03bd\u03c9\u03bd \u03bc\u03c5\u03ce\u03bd \u03ba\u03b1\u03b9 \u03b9\u03c3\u03c4\u03ce\u03bd. \u0398\u03b5\u03c9\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03c0\u03c9\u03c2 \u03af\u03c3\u03c9\u03c2 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03c4\u03b5\u03bb\u03b9\u03ba\u03cc \u03c3\u03c4\u03ac\u03b4\u03b9\u03bf \u03c4\u03b7\u03c2 \u0397\u03a4 (8).<\/li>\n
  4. \u0397 \u03b1\u03c4\u03c1\u03bf\u03c6\u03b9\u03ba\u03ae \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03af\u03c4\u03b9\u03b4\u03b1 \u03c3\u03c5\u03bd\u03bf\u03b4\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03c5\u03c0\u03bf\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03c3\u03bc\u03cc \u03ba\u03b1\u03b9 \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03ad\u03bd\u03b1\u03bd \u03bc\u03b9\u03ba\u03c1\u03cc \u03ba\u03b1\u03b9 \u03b1\u03c4\u03c1\u03bf\u03c6\u03b9\u03ba\u03cc \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03ae \u03bc\u03b5 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03b4\u03b9\u03ae\u03b8\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c0\u03b1\u03c1\u03ad\u03b3\u03c7\u03c5\u03bc\u03b1 \u03c0\u03bf\u03c5 \u03ad\u03c7\u03b5\u03b9 \u03b1\u03bd\u03c4\u03b9\u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03b1\u03b8\u03b5\u03af \u03b1\u03c0\u03cc \u03b9\u03bd\u03ce\u03b4\u03b7 \u03b9\u03c3\u03c4\u03cc. \u0391\u03bd\u03c4\u03b1\u03b3\u03c9\u03bd\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03b5\u03bd\u03b1\u03bd\u03c4\u03af\u03bf\u03bd \u03c4\u03bf\u03c5 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03c4\u03b7\u03c2 TSH \u03b2\u03c1\u03af\u03c3\u03ba\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf 20-50% \u03c4\u03c9\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03bc\u03b5 \u03b1\u03c4\u03c1\u03bf\u03c6\u03b9\u03ba\u03ae \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03af\u03c4\u03b9\u03b4\u03b1 \u03c3\u03b5 \u03c3\u03c7\u03ad\u03c3\u03b7 \u03bc\u03b5 10% \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u0397\u03a4, \u03c5\u03c0\u03bf\u03b4\u03b7\u03bb\u03ce\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c0\u03b9\u03b8\u03b1\u03bd\u03ae \u03b5\u03bc\u03c0\u03bb\u03bf\u03ba\u03ae \u03c3\u03c4\u03b7\u03bd \u03b1\u03b9\u03c4\u03b9\u03bf\u03c0\u03b1\u03b8\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5 (9).<\/li>\n
  5. \u0386\u03bb\u03bb\u03b7 \u03bc\u03bf\u03c1\u03c6\u03ae \u03c4\u03b7\u03c2 \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03b7\u03c2 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03af\u03c4\u03b9\u03b4\u03b1\u03c2 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03b7 \u03c3\u03b9\u03c9\u03c0\u03b7\u03bb\u03ae (\u03b1\u03bd\u03ce\u03b4\u03c5\u03bd\u03b7) \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03af\u03c4\u03b9\u03b4\u03b1 \u03bc\u03b5 \u03c4\u03b9\u03c2 \u03c5\u03c0\u03bf\u03b4\u03b9\u03b1\u03b9\u03c1\u03ad\u03c3\u03b5\u03b9\u03c2 \u03c4\u03b7\u03c2: \u03c4\u03b7 \u03c3\u03c0\u03bf\u03c1\u03b1\u03b4\u03b9\u03ba\u03ae \u03ba\u03b1\u03b9 \u03c4\u03b7 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03af\u03c4\u03b9\u03b4\u03b1 \u03c4\u03b7\u03c2 \u03bb\u03bf\u03c7\u03b5\u03af\u03b1\u03c2. \u039a\u03b1\u03b9 \u03bf\u03b9 \u03b4\u03cd\u03bf \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b1\u03c1\u03bf\u03b4\u03b9\u03ba\u03ad\u03c2 \u03b1\u03bb\u03bb\u03ac \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03c0\u03b1\u03bd\u03b5\u03bc\u03c6\u03b1\u03bd\u03b9\u03c3\u03c4\u03bf\u03cd\u03bd.<\/li>\n
  6. \u03a0\u03c1\u03cc\u03c3\u03c6\u03b1\u03c4\u03b1 \u03bc\u03b9\u03b1 \u03bd\u03ad\u03b1 \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b1 \u0397\u03a4 \u03bc\u03b5 \u03af\u03bd\u03c9\u03c3\u03b7, \u03b7 \u0399gG4-\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03af\u03c4\u03b9\u03b4\u03b1, \u03ad\u03c7\u03b5\u03b9 \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03b1\u03c6\u03b5\u03af \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5\u03c2 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03ad\u03c2. \u039f\u03b9 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf\u03b9 \u03c4\u03b7 \u03b8\u03b5\u03c9\u03c1\u03bf\u03cd\u03bd \u03c9\u03c2 \u03b5\u03bd\u03c4\u03b5\u03bb\u03ce\u03c2 \u03be\u03b5\u03c7\u03c9\u03c1\u03b9\u03c3\u03c4\u03ae \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03bf\u03bd\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1, \u03c0\u03bf\u03c5 \u03af\u03c3\u03c9\u03c2 \u03bf\u03bc\u03bf\u03b9\u03ac\u03b6\u03b5\u03b9 \u03bc\u03b5 \u03c4\u03b1 \u03b1\u03c1\u03c7\u03b9\u03ba\u03ac \u03c3\u03c4\u03ac\u03b4\u03b9\u03b1 \u03c4\u03b7\u03c2 \u0397\u03a4, \u03b5\u03bd\u03ce \u03ba\u03ac\u03c0\u03bf\u03b9\u03bf\u03b9 \u03b8\u03b5\u03c9\u03c1\u03bf\u03cd\u03bd \u03c0\u03c9\u03c2 \u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03b9\u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03af\u03c4\u03b9\u03b4\u03b1 Riedel (10). \u03a7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c5\u03c0\u03b5\u03c1\u03b3\u03b1\u03bc\u03bc\u03b1\u03c3\u03c6\u03b1\u03b9\u03c1\u03b9\u03bd\u03b1\u03b9\u03bc\u03af\u03b1, \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf \u03b1\u03c1\u03b9\u03b8\u03bc\u03cc \u0399gG4 \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c3\u03c4\u03bf \u03c0\u03b5\u03c1\u03b9\u03c6\u03b5\u03c1\u03b9\u03ba\u03cc \u03b1\u03af\u03bc\u03b1, \u03b5\u03bd\u03b4\u03bf\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae \u03af\u03bd\u03c9\u03c3\u03b7, \u03b4\u03b9\u03ac\u03c7\u03c5\u03c4\u03b7 \u03c5\u03c0\u03bf\u03b7\u03c7\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1, \u03bc\u03b9\u03ba\u03c1\u03cc\u03c4\u03b5\u03c1\u03b7 \u03b7\u03bb\u03b9\u03ba\u03af\u03b1 \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7\u03c2, \u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03bf \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03bf \u03b1\u03bd\u03c4\u03b9\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd, \u03bc\u03b9\u03ba\u03c1\u03cc\u03c4\u03b5\u03c1\u03b7 \u03b1\u03bd\u03b1\u03bb\u03bf\u03b3\u03af\u03b1 \u03b3\u03c5\u03bd\u03b1\u03b9\u03ba\u03ce\u03bd\/\u03b1\u03bd\u03b4\u03c1\u03ce\u03bd \u03ba\u03b1\u03b9 \u03c0\u03b9\u03bf \u03c3\u03c5\u03c7\u03bd\u03ae \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7 \u03c5\u03c0\u03bf\u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03bf\u03cd \u03c5\u03c0\u03bf\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03c3\u03bc\u03bf\u03cd \u03c3\u03b5 \u03c3\u03c7\u03ad\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b7\u03bd \u0397\u03a4 (11). \u039c\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03bc\u03c6\u03b1\u03bd\u03b9\u03c3\u03c4\u03b5\u03af \u03c3\u03c4\u03b1 \u03c0\u03bb\u03b1\u03af\u03c3\u03b9\u03b1 \u03bc\u03b9\u03b1\u03c2 \u03bd\u03ad\u03b1\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03bf\u03bd\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c0\u03bf\u03c5 \u03bf\u03bd\u03bf\u03bc\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u039d\u03cc\u03c3\u03bf\u03c2 \u03c3\u03c7\u03b5\u03c4\u03b9\u03b6\u03cc\u03bc\u03b5\u03bd\u03b7 \u03bc\u03b5 IgG4 (\u0399gG4-related disease). \u0397 \u03bd\u03cc\u03c3\u03bf\u03c2 \u03b1\u03c5\u03c4\u03ae \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03b9 \u03bf\u03b3\u03ba\u03cc\u03bc\u03bf\u03c1\u03c6\u03b5\u03c2 \u03b2\u03bb\u03ac\u03b2\u03b5\u03c2 \u03c3\u03c4\u03bf \u03c0\u03ac\u03b3\u03ba\u03c1\u03b5\u03b1\u03c2, \u03c4\u03bf\u03c5\u03c2 \u03b4\u03b1\u03ba\u03c1\u03c5\u03ca\u03ba\u03bf\u03cd\u03c2 \u03b1\u03b4\u03ad\u03bd\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b9\u03c2 \u03c7\u03bf\u03bb\u03b7\u03c6\u03cc\u03c1\u03b5\u03c2 \u03bf\u03b4\u03bf\u03cd\u03c2, \u03bf\u03c0\u03b9\u03c3\u03b8\u03bf\u03c0\u03b5\u03c1\u03b9\u03c4\u03bf\u03bd\u03b1\u03ca\u03ba\u03ae \u03af\u03bd\u03c9\u03c3\u03b7, \u03c3\u03ba\u03bb\u03b7\u03c1\u03c5\u03bd\u03c4\u03b9\u03ba\u03ae \u03c7\u03bf\u03bb\u03b1\u03b3\u03b3\u03b5\u03b9\u03af\u03c4\u03b9\u03b4\u03b1 \u03ba\u03b1\u03b9 \u03c3\u03b9\u03b1\u03bb\u03b1\u03b4\u03b5\u03bd\u03af\u03c4\u03b9\u03b4\u03b1, \u03c8\u03b5\u03c5\u03b4\u03bf\u03cc\u03b3\u03ba\u03bf\u03c5\u03c2 \u03ae\u03c0\u03b1\u03c4\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03bf\u03c6\u03b8\u03b1\u03bb\u03bc\u03b9\u03ba\u03bf\u03cd \u03ba\u03cc\u03b3\u03c7\u03bf\u03c5, \u03bb\u03b5\u03bc\u03c6\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae \u03b4\u03b9\u03ac\u03bc\u03b5\u03c3\u03b7 \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03af\u03b1, \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03b7 \u03c0\u03b1\u03b3\u03ba\u03c1\u03b5\u03b1\u03c4\u03af\u03c4\u03b9\u03b4\u03b1, \u03c3\u03c9\u03bb\u03b7\u03bd\u03b1\u03c1\u03b9\u03bf\u03b4\u03b9\u03ac\u03bc\u03b5\u03c3\u03b7 \u03bd\u03b5\u03c6\u03c1\u03af\u03c4\u03b9\u03b4\u03b1, \u03c0\u03b1\u03c7\u03c5\u03bc\u03b7\u03bd\u03b9\u03b3\u03b3\u03af\u03c4\u03b9\u03b4\u03b1 \u03ba\u03b1\u03b9 \u03c5\u03c0\u03bf\u03c6\u03c5\u03c3\u03af\u03c4\u03b9\u03b4\u03b1. \u039f\u03b9 \u03ba\u03b1\u03c4\u03b5\u03c5\u03b8\u03c5\u03bd\u03c4\u03ae\u03c1\u03b9\u03b5\u03c2 \u03bf\u03b4\u03b7\u03b3\u03af\u03b5\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03bd\u03ad\u03bf\u03c5 \u03b1\u03c5\u03c4\u03bf\u03cd \u03c3\u03c5\u03bd\u03b4\u03c1\u03cc\u03bc\u03bf\u03c5 \u03b4\u03b7\u03bc\u03bf\u03c3\u03b9\u03b5\u03cd\u03b8\u03b7\u03ba\u03b1\u03bd \u03c0\u03c1\u03cc\u03c3\u03c6\u03b1\u03c4\u03b1 \u03c3\u03c4\u03b7 \u03c3\u03c5\u03bd\u03ac\u03bd\u03c4\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 Research Program for Intractable Disease \u03c3\u03c4\u03b7\u03bd \u0399\u03b1\u03c0\u03c9\u03bd\u03af\u03b1 (12).<\/li>\n<\/ol>\n

    \u03a4\u03ad\u03bb\u03bf\u03c2 \u03b7 GD \u03bf\u03c6\u03b5\u03af\u03bb\u03b5\u03c4\u03b1\u03b9.\u03c3\u03b5 \u03b4\u03b9\u03b5\u03b3\u03b5\u03c1\u03c4\u03b9\u03ba\u03ac \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03c4\u03bf\u03c5 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03c4\u03b7\u03c2 TSH (TSAb) \u03ba\u03b1\u03b9 \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c5\u03c0\u03b5\u03c1\u03c0\u03bb\u03b1\u03c3\u03af\u03b1 \u03c4\u03c9\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03b8\u03c5\u03bb\u03b1\u03ba\u03af\u03c9\u03bd, \u03bc\u03b9\u03ba\u03c1\u03cc\u03c4\u03b5\u03c1\u03b7 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03b4\u03b9\u03ae\u03b8\u03b7\u03c3\u03b7 \u03b1\u03c0\u2019\u03cc\u03c4\u03b9 \u03b7 \u0397\u03a4 (\u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03a4h2 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1) \u03ba\u03b1\u03b9 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd (2). \u03a3\u03c4\u03b1 \u03b1\u03c1\u03c7\u03b9\u03ba\u03ac \u03c3\u03c4\u03ac\u03b4\u03b9\u03b1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c9\u03c2 \u03c5\u03c0\u03bf\u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc\u03c2 \u03c5\u03c0\u03b5\u03c1\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03c3\u03bc\u03cc\u03c2 \u03bc\u03b5 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03c4\u03b9\u03bc\u03ad\u03c2 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03bf\u03c1\u03bc\u03bf\u03bd\u03ce\u03bd \u03ba\u03b1\u03b9 TSH \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b7 \u03c4\u03bf\u03c5 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03bf\u03cd. \u0397 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03bf\u03c5 \u03c5\u03c0\u03bf\u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03bf\u03cd \u03c5\u03c0\u03b5\u03c1\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03c3\u03bc\u03bf\u03cd \u03ba\u03c5\u03bc\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc 0,7-12,4% \u03ba\u03b1\u03b9 \u03bf \u03c1\u03c5\u03b8\u03bc\u03cc\u03c2 \u03b5\u03be\u03ad\u03bb\u03b9\u03be\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03c3\u03b5 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03c5\u03c0\u03b5\u03c1\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03c3\u03bc\u03cc \u03b5\u03af\u03bd\u03b1\u03b9 5% \u03b1\u03bd\u03ac \u03ad\u03c4\u03bf\u03c2 (13,14).<\/p>\n

    2. \u0391\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b1\u03c0\u03ac\u03bd\u03c4\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03bf\u03c3\u03af\u03b1 <\/b><\/h4>\n

    \u03a0\u03c1\u03bf\u03c4\u03bf\u03cd \u03b1\u03bd\u03b1\u03bb\u03c5\u03b8\u03b5\u03af \u03bf \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc\u03c2 \u03c1\u03cc\u03bb\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03bf\u03cd \u03c3\u03c5\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c3\u03c4\u03b7\u03bd \u03b1\u03b9\u03c4\u03b9\u03bf\u03c0\u03b1\u03b8\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 \u0398\u0391, \u03ba\u03c1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03ba\u03cc\u03c0\u03b9\u03bc\u03b7 \u03b7 \u03b5\u03bd \u03c3\u03c5\u03bd\u03c4\u03bf\u03bc\u03af\u03b1 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b2\u03b1\u03c3\u03b9\u03ba\u03ce\u03bd \u03b1\u03c1\u03c7\u03ce\u03bd \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2 \u03c4\u03bf\u03c5 \u03cc\u03c3\u03bf\u03bd \u03b1\u03c6\u03bf\u03c1\u03ac \u03c3\u03c4\u03b7\u03bd \u03b1\u03bd\u03c4\u03b9\u03b3\u03bf\u03bd\u03bf\u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1\u03c3\u03b7, \u03c4\u03b9\u03c2 \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b5\u03c2 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd (CD4, CD8, B, Tregs, Th17, Th22, Th23, Tfh) \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03ba\u03c5\u03c4\u03bf\u03ba\u03b9\u03bd\u03ce\u03bd \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7\/\u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03ae \u03c4\u03bf\u03c5\u03c2 \u03bc\u03b5 \u03c4\u03b1 \u03b1\u03bd\u03c4\u03b9\u03b3\u03bf\u03bd\u03bf\u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03b9\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 (antigen presenting cells\/APC) \u03ba\u03b1\u03b8\u03ce\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03c9\u03bd \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03ce\u03bd \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03bf\u03c7\u03ae\u03c2 \u03ba\u03b1\u03b9 \u03b4\u03b9\u03b1\u03c6\u03c5\u03b3\u03ae\u03c2 \u03b1\u03c0\u03cc \u03b1\u03c5\u03c4\u03ae\u03bd.
    \n<\/b><\/p>\n

    2.1. \u039a\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b5\u03c2 \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c4\u03bf\u03c5 \u03b1\u03bd\u03bf\u03c3\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03bf\u03cd \u03c3\u03c5\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2 \u03bc\u03b5 \u03c1\u03cc\u03bb\u03bf \u03c3\u03c4\u03b7\u03bd \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 \u0398\u0391<\/b><\/h5>\n

    \u0397 \u03b2\u03b1\u03c3\u03b9\u03ba\u03ae \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03c4\u03bf\u03c5 <\/b>\u03b1\u03bd\u03bf\u03c3\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03bf\u03cd \u03c3\u03c5\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03b4\u03b9\u03ac\u03ba\u03c1\u03b9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03c9\u03bd \u03b1\u03c0\u03cc \u03c4\u03b1 \u03b5\u03be\u03c9\u03b3\u03b5\u03bd\u03ae \u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03b1 \u03ba\u03b1\u03b9 \u03b7 \u03b5\u03be\u03bf\u03c5\u03b4\u03b5\u03c4\u03ad\u03c1\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c4\u03b5\u03bb\u03b5\u03c5\u03c4\u03b1\u03af\u03c9\u03bd. \u0393\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b5\u03c0\u03af\u03c4\u03b5\u03c5\u03be\u03b7 \u03c4\u03bf\u03c5 \u03c3\u03c4\u03cc\u03c7\u03bf\u03c5 \u03b1\u03c5\u03c4\u03bf\u03cd \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf \u03c1\u03cc\u03bb\u03bf\u03c2 \u03c4\u03c9\u03bd CD4 T \u03b2\u03bf\u03b7\u03b8\u03b7\u03c4\u03b9\u03ba\u03ce\u03bd \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd, \u03c4\u03b1 \u03bf\u03c0\u03bf\u03af\u03b1 \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u03b1\u03bd\u03c4\u03b9\u03b3\u03bf\u03bd\u03b9\u03ba\u03ae \u03b5\u03c0\u03b1\u03c6\u03ae, \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b4\u03cd\u03bf \u03c5\u03c0\u03bf\u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b5\u03c2, \u03c4\u03b1 Th1 \u03ba\u03b1\u03b9 \u03c4\u03b1 Th2 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1. \u03a4\u03b1 Th1 \u03b5\u03ba\u03ba\u03c1\u03af\u03bd\u03bf\u03c5\u03bd \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03b9\u03bd\u03c4\u03b5\u03c1\u03bb\u03b5\u03c5\u03ba\u03af\u03bd\u03b7-2 (IL-2), \u03b9\u03bd\u03c4\u03b5\u03c1\u03c6\u03b5\u03c1\u03cc\u03bd\u03b7-\u03b3 (IFN-\u03b3) \u03ba\u03b1\u03b9 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1 \u03bd\u03ad\u03ba\u03c1\u03c9\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd \u03cc\u03b3\u03ba\u03c9\u03bd (TNF-\u03b1), \u03c1\u03c5\u03b8\u03bc\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7\u03bd \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03b1\u03bd\u03bf\u03c3\u03af\u03b1, \u03b5\u03bd\u03ce \u03c4\u03b1 Th2 \u03b5\u03ba\u03ba\u03c1\u03af\u03bd\u03bf\u03c5\u03bd \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03b9\u03bd\u03c4\u03b5\u03c1\u03bb\u03b5\u03c5\u03ba\u03af\u03bd\u03b7 4,5,6 \u03ba\u03b1\u03b9 10, \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7 \u03c7\u03c5\u03bc\u03b9\u03ba\u03ae \u03b1\u03bd\u03bf\u03c3\u03af\u03b1 (\u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03b1\u03c0\u03cc B \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1) (15). \u0391\u03bd\u03c4\u03af\u03b8\u03b5\u03c4\u03b1 \u03c4\u03b1 CD8 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03c4\u03bf\u03be\u03b9\u03ba\u03ac \u03a4 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03b5\u03ba\u03c6\u03c1\u03ac\u03b6\u03bf\u03c5\u03bd \u03b1\u03bd\u03c4\u03b9\u03b3\u03bf\u03bd\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03cc \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 TCR \u03bf \u03bf\u03c0\u03bf\u03af\u03bf\u03c2 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03b1 \u03c4\u03b1 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03b9\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03bc\u03cc\u03c1\u03b9\u03b1 \u03c4\u03bf\u03c5 \u03bc\u03b5\u03af\u03b6\u03bf\u03bd\u03bf\u03c2 \u03c3\u03c5\u03bc\u03c0\u03bb\u03ad\u03b3\u03bc\u03b1\u03c4\u03bf\u03c2 \u03b9\u03c3\u03c4\u03bf\u03c3\u03c5\u03bc\u03b2\u03b1\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 MHC-I \u03c0\u03bf\u03c5 \u03b5\u03ba\u03c6\u03c1\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03c6\u03ac\u03bd\u03b5\u03b9\u03b1 \u03c4\u03c9\u03bd APC. \u03a4\u03b1 CD8 \u03a4 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b5\u03bc\u03c0\u03bb\u03ad\u03ba\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03c1\u03bf\u03c6\u03ae \u03c4\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c0\u03bf\u03c5 \u03c6\u03ad\u03c1\u03bf\u03c5\u03bd \u03c4\u03b1 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b1 \u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03b1, \u03bc\u03ad\u03c3\u03c9 \u03ba\u03c5\u03c4\u03bf\u03c4\u03bf\u03be\u03b9\u03bd\u03ce\u03bd \u03cc\u03c0\u03c9\u03c2 \u03c0\u03b5\u03c1\u03c6\u03bf\u03c1\u03af\u03bd\u03b5\u03c2 \u03ba\u03b1\u03b9 granzyme. \u0393\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03bd\u03c4\u03b9\u03b3\u03bf\u03bd\u03bf\u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1\u03c3\u03b7 \u03b1\u03c0\u03b1\u03c1\u03b1\u03af\u03c4\u03b7\u03c4\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03c0\u03c1\u03cc\u03c3\u03b4\u03b5\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03bf\u03c5 \u03c3\u03b5 \u03bc\u03cc\u03c1\u03b9\u03b1 MHC-I \u03ba\u03b1\u03b9 \u0399\u0399 \u03c4\u03b7\u03c2 \u03b5\u03c0\u03b9\u03c6\u03ac\u03bd\u03b5\u03b9\u03b1\u03c2 \u03c4\u03c9\u03bd \u0391PC \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03c3\u03c5\u03bd\u03ad\u03c7\u03b5\u03b9\u03b1 \u03b7 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1\u03c3\u03ae \u03c4\u03bf\u03c5 \u03c3\u03c4\u03bf\u03c5\u03c2 TCR \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03b5\u03af\u03c2 \u03c4\u03b7\u03c2 \u03b5\u03c0\u03b9\u03c6\u03ac\u03bd\u03b5\u03b9\u03b1\u03c2 \u03c4\u03c9\u03bd CD8 \u03ba\u03b1\u03b9 CD4 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03bf\u03b9\u03c7\u03b1. \u03a4\u03b1 APC (\u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b4\u03b5\u03bd\u03b4\u03c1\u03b9\u03c4\u03b9\u03ba\u03ac, \u03bc\u03b1\u03ba\u03c1\u03bf\u03c6\u03ac\u03b3\u03b1 \u03ba\u03b1\u03b9 \u0392 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1) \u03b5\u03bd\u03b4\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03ce\u03bd\u03bf\u03c5\u03bd \u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03b1 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03c3\u03c5\u03bd\u03ad\u03c7\u03b5\u03b9\u03b1 \u03c4\u03b1 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03b9\u03ac\u03b6\u03bf\u03c5\u03bd \u03bc\u03ad\u03c3\u03c9 \u03c4\u03c9\u03bd \u03bc\u03bf\u03c1\u03af\u03c9\u03bd MHC-\u0399 \u03ba\u03b1\u03b9 \u0399\u0399 \u03c0\u03bf\u03c5 \u03c6\u03ad\u03c1\u03bf\u03c5\u03bd \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03c6\u03ac\u03bd\u03b5\u03b9\u03ac \u03c4\u03bf\u03c5\u03c2. \u0399\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b7 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03c4\u03bf \u03b3\u03b5\u03b3\u03bf\u03bd\u03cc\u03c2 \u03c0\u03c9\u03c2 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b1 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b1 \u03b5\u03c0\u03b9\u03b8\u03b7\u03bb\u03b9\u03b1\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1, \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03c4\u03c9\u03bd \u03bf\u03c0\u03bf\u03af\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03b8\u03c5\u03c1\u03b5\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1, \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03b4\u03c1\u03bf\u03c5\u03bd \u03c9\u03c2 APC \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03b9\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03c2 \u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03b1 \u03c3\u03c4\u03b1 \u03a4 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1. \u0395\u03c0\u03af\u03c3\u03b7\u03c2 \u03b7 \u0399L23 \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03ac\u03b3\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03b4\u03b5\u03bd\u03b4\u03c1\u03b9\u03c4\u03b9\u03ba\u03ac \u03ba\u03b1\u03b9 \u03bc\u03b1\u03ba\u03c1\u03bf\u03c6\u03ac\u03b3\u03b1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03c4\u03b7\u03bd \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03b7 \u03b1\u03c0\u03ac\u03bd\u03c4\u03b7\u03c3\u03b7 \u03bc\u03ad\u03c3\u03c9 \u03bc\u03b9\u03b1\u03c2 \u03bd\u03b5\u03bf\u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03b1\u03c6\u03b5\u03af\u03c3\u03b1\u03c2 \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b1\u03c2 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd, \u03c4\u03c9\u03bd Th17 (2,16).<\/p>\n

    \u0397 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03a4 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af, \u03b5\u03ba\u03c4\u03cc\u03c2 \u03c4\u03bf\u03c5 \u03c3\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03ad\u03c7\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03c0\u03c1\u03cc\u03c3\u03b4\u03b5\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03c9\u03bd \u03c4\u03c9\u03bd \u03a4 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd (\u03a4CR) \u03bc\u03b5 \u03c4\u03b1 \u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03b1 \u03c4\u03b1 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c6\u03ad\u03c1\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b1 MHC (I \u03ba\u03b1\u03b9 \u0399\u0399) \u03bc\u03cc\u03c1\u03b9\u03b1 \u03c4\u03c9\u03bd APC, \u03ba\u03b1\u03b9 \u03ad\u03bd\u03b1 \u03c3\u03c5\u03bd-\u03b4\u03b9\u03b5\u03b3\u03b5\u03c1\u03c4\u03b9\u03ba\u03cc \u03c3\u03ae\u03bc\u03b1. \u03a5\u03c0\u03b5\u03cd\u03b8\u03c5\u03bd\u03b5\u03c2 \u03b3\u03b9\u2019\u03b1\u03c5\u03c4\u03cc \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2 \u03b5\u03c0\u03b9\u03c6\u03b1\u03bd\u03b5\u03af\u03b1\u03c2 \u03c4\u03c9\u03bd APC, \u03bc\u03b5 \u03ba\u03c5\u03c1\u03b9\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03b5\u03ba\u03c0\u03c1\u03bf\u03c3\u03ce\u03c0\u03bf\u03c5\u03c2 \u03c4\u03b9\u03c2 B7.1 (CD80) \u03ba\u03b1\u03b9 B7.2 (CD70). \u039f\u03b9 B7.1 \u03b4\u03b9\u03b5\u03b3\u03b5\u03af\u03c1\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03c4\u03c9\u03bd \u03a4h1 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd, \u03b5\u03bd\u03ce \u03bf\u03b9 \u03927.2 \u03c4\u03c9\u03bd Th2 (17) (\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 1<\/b>).<\/b><\/p>\n

    \n

    \u00a0\"10.10-figure1\"
    \n\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 1.<\/em><\/b> \u0395\u03bd\u03b1\u03bb\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03cc \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03b7\u03c2 \u03b1\u03bd\u03c4\u03b9\u03b3\u03bf\u03bd\u03bf\u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1\u03c3\u03b7\u03c2 \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03bf \u03c3\u03c5\u03bd\u03b4\u03b9\u03b5\u03b3\u03b5\u03c1\u03c4\u03b9\u03ba\u03cc \u03bc\u03cc\u03c1\u03b9\u03bf: (a) \u03a3\u03cd\u03bd\u03b4\u03b5\u03c3\u03b7 \u03c4\u03bf\u03c5 B7\u00b71 \u03bc\u03b5 \u03c4\u03bf CD28 \u03b5\u03c0\u03ac\u03b3\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b4\u03b9\u03ad\u03b3\u03b5\u03c1\u03c3\u03b7 Th1 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd (b) \u03a3\u03cd\u03bd\u03b4\u03b5\u03c3\u03b7 \u03c4\u03bf\u03c5 B7\u00b72 \u03bc\u03b5 \u03c4\u03bf CD28 \u03b5\u03c0\u03ac\u03b3\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b4\u03b9\u03ad\u03b3\u03b5\u03c1\u03c3\u03b7 Th2 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd (c) \u0391\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 CTLA-4 \u03bc\u03b5 \u03c4\u03bf B7\u00b71 \u03ae B7\u00b72 \u03b1\u03bd\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03b5\u03b9 \u03c4\u03b7 \u03b4\u03b9\u03ad\u03b3\u03b5\u03c1\u03c3\u03b7 \u03c4\u03c9\u03bd T \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03bf\u03b4\u03b7\u03b3\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c3\u03b5 \u03b1\u03bd\u03ad\u03c1\u03b3\u03b9\u03b1. Fountoulakis S & Tsatsoulis A, Clin Endocrinol (Oxf) 2004,with permission.<\/p>\n

    \n

    \u0397 \u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c4\u03c9\u03bd \u03927 \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03ce\u03bd \u03bc\u03b5 \u03c4\u03bf CD28 \u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03bf \u03b5\u03c0\u03b9\u03c6\u03b1\u03bd\u03b5\u03af\u03b1\u03c2 \u03c4\u03c9\u03bd \u03b1\u03bd\u03b5\u03bd\u03b5\u03c1\u03b3\u03ce\u03bd \u03a4 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03c4\u03b7\u03bd \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03ae \u03c4\u03bf\u03c5\u03c2, \u03b5\u03bd\u03ce \u03c0\u03c1\u03cc\u03c3\u03b4\u03b5\u03c3\u03b7 \u03c3\u03c4\u03bf CTLA-4 \u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03bf \u03b5\u03c0\u03b9\u03c6\u03b1\u03bd\u03b5\u03af\u03b1\u03c2 \u03ae\u03b4\u03b7 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03c9\u03bd \u03a4 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03ad\u03c7\u03b5\u03b9 \u03c9\u03c2 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03b7 \u03bc\u03b5\u03c4\u03ac\u03b4\u03bf\u03c3\u03b7 \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03bf\u03cd \u03c3\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2. To CTLA-4 \u03b1\u03c0\u03b1\u03bd\u03c4\u03ac\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03b4\u03b9\u03b1\u03bb\u03c5\u03c4\u03ae \u03bc\u03bf\u03c1\u03c6\u03ae (s-CTLA-4) \u03bc\u03b5 \u03ac\u03b3\u03bd\u03c9\u03c3\u03c4\u03bf \u03bc\u03ad\u03c7\u03c1\u03b9 \u03c3\u03c4\u03b9\u03b3\u03bc\u03ae\u03c2 \u03c1\u03cc\u03bb\u03bf (18). \u0394\u03cd\u03bf \u03bd\u03ad\u03b1 \u03b6\u03b5\u03cd\u03b3\u03b7 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03c9\u03bd-\u03c3\u03c5\u03bd\u03b4\u03b5\u03c4\u03ce\u03bd \u03ad\u03c7\u03bf\u03c5\u03bd \u03b5\u03bc\u03c0\u03bb\u03b1\u03ba\u03b5\u03af \u03c3\u03c4\u03b7 \u03bc\u03b5\u03c4\u03ac\u03b4\u03bf\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c3\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd. \u0397 \u03927RP-1 (ICOSL) \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 \u03c0\u03c1\u03bf\u03c3\u03b4\u03ad\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 ICOS \u03ba\u03b1\u03b9 \u03bc\u03b5\u03c4\u03b1\u03b4\u03af\u03b4\u03b5\u03b9 \u03b4\u03b9\u03b5\u03b3\u03b5\u03c1\u03c4\u03b9\u03ba\u03cc \u03c3\u03ae\u03bc\u03b1 (19), \u03b5\u03bd\u03ce \u03b7 \u03c0\u03c1\u03cc\u03c3\u03b4\u03b5\u03c3\u03b7 \u03c4\u03c9\u03bd B7-H1 (PD-L1) \u03ba\u03b1\u03b9 B7-DC (PD-L2) \u03bc\u03b5 \u03c4\u03bf\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 PD-1 \u03bc\u03b5\u03c4\u03b1\u03b4\u03af\u03b4\u03b5\u03b9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03b1\u03bb\u03c4\u03b9\u03ba\u03cc \u03c3\u03ae\u03bc\u03b1 (20).<\/p>\n

    \u03a3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03c1\u03cc\u03bb\u03bf \u03c3\u03c4\u03b7\u03bd \u03ad\u03ba\u03b2\u03b1\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03bd\u03c4\u03b9\u03b3\u03bf\u03bd\u03bf\u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae\u03c2 \u03b1\u03c0\u03ac\u03bd\u03c4\u03b7\u03c3\u03b7 \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c0\u03c9\u03c2 \u03ad\u03c7\u03bf\u03c5\u03bd \u03ba\u03b1\u03b9 \u03ba\u03ac\u03c0\u03bf\u03b9\u03b5\u03c2 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ac \u03bd\u03ad\u03b5\u03c2 \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b5\u03c2 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd (T \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \/\u03a4 regulatory cells\/Tregs, \u03a4h17, \u03a4h22 \u03ba\u03b1\u03b9 Tfh\/\u03a4 follicular helper cells) \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03c4\u03b1 \u0392 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1.<\/p>\n

      \n
    1. T\u03b1 \u03a4regs \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03bf\u03cd\u03bd \u03bc\u03b9\u03b1 \u03bf\u03bc\u03ac\u03b4\u03b1 CD4 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c4\u03b1 \u03bf\u03c0\u03bf\u03af\u03b1 \u03b5\u03ba\u03c6\u03c1\u03ac\u03b6\u03bf\u03c5\u03bd \u03ad\u03bd\u03c4\u03bf\u03bd\u03b1 \u03c4\u03bf \u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03bf \u03b5\u03c0\u03b9\u03c6\u03b1\u03bd\u03b5\u03af\u03b1\u03c2 CD25 (IL2a-receptor) \u03ba\u03b1\u03b9 \u03c4\u03bf\u03bd \u03b5\u03bd\u03b4\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03b9\u03bf \u03bc\u03b5\u03c4\u03b1\u03b3\u03c1\u03b1\u03c6\u03b9\u03ba\u03cc \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1 FoxP3. \u0388\u03c7\u03bf\u03c5\u03bd \u03ba\u03cd\u03c1\u03b9\u03bf \u03c1\u03cc\u03bb\u03bf \u03c3\u03c4\u03b7 \u03c1\u03cd\u03b8\u03bc\u03b9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae\u03c2 \u03b1\u03c0\u03ac\u03bd\u03c4\u03b7\u03c3\u03b7\u03c2 \u03b1\u03c3\u03ba\u03ce\u03bd\u03c4\u03b1\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03b1\u03bb\u03c4\u03b9\u03ba\u03ae \u03b4\u03c1\u03ac\u03c3\u03b7 \u03c3\u03c4\u03b1 CD4 \u03ba\u03b1\u03b9 CD8 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1, \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03b1\u03bd\u03bf\u03bc\u03ad\u03bd\u03c9\u03bd \u03c4\u03c9\u03bd \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ce\u03bd \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c0\u03bf\u03c5 \u03b4\u03b9\u03b1\u03c6\u03b5\u03cd\u03b3\u03bf\u03c5\u03bd \u03c4\u03b7\u03c2 \u03ba\u03b5\u03bd\u03c4\u03c1\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03bf\u03c7\u03ae\u03c2 \u03ae \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 de novo (\u03a4 effectors). \u03a4\u03b1 \u03c4\u03b5\u03bb\u03b5\u03c5\u03c4\u03b1\u03af\u03b1 \u03ad\u03c4\u03b7 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03b1\u03c6\u03b5\u03af \u03c0\u03bf\u03bb\u03bb\u03ad\u03c2 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c5\u03c0\u03bf\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03c4\u03c9\u03bd Tregs (induced-iTregs, \u03a4r1, natural occurring-nTregs) \u03c7\u03c9\u03c1\u03af\u03c2 \u03b1\u03ba\u03cc\u03bc\u03b1 \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03b1\u03c6\u03ae\u03c2 \u03bf \u03b2\u03b1\u03b8\u03bc\u03cc\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03b1\u03bb\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b4\u03c1\u03ac\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b8\u03b5\u03bc\u03b9\u03ac\u03c2 (21,22). \u0393\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03ae \u03c4\u03bf\u03c5\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03b1\u03c1\u03b1\u03af\u03c4\u03b7\u03c4\u03b7 \u03b7 \u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b1 APC \u03ba\u03b1\u03b9 \u03c4\u03b1 CD4 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03bc\u03ad\u03c3\u03c9 \u03c4\u03c9\u03bd \u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03c9\u03bd \u03b5\u03c0\u03b9\u03c6\u03b1\u03bd\u03b5\u03af\u03b1\u03c2 \u03c4\u03bf\u03c5\u03c2. \u0393\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03ae \u03c4\u03bf\u03c5\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03b1\u03c1\u03b1\u03af\u03c4\u03b7\u03c4\u03b7 \u03b7 IL-2 \u03b5\u03bd\u03ce \u03b7 \u03b4\u03c1\u03ac\u03c3\u03b7 \u03c4\u03bf\u03c5\u03c2 \u03b1\u03c3\u03ba\u03b5\u03af\u03c4\u03b1\u03b9 \u03bc\u03ad\u03c3\u03c9 IL-10 \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03c5\u03bd \u03ba\u03b1\u03b9 \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03b4\u03c1\u03b1 \u03c3\u03c4\u03b7 \u03c3\u03c5\u03bd\u03ad\u03c7\u03b5\u03b9\u03b1 \u03c3\u03c4\u03b1 \u03a4 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1. \u03a1\u03cc\u03bb\u03bf\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03b1\u03c0\u03bf\u03c6\u03c5\u03b3\u03ae \u03c4\u03b7\u03c2 \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7\u03c2 \u03bf\u03c1\u03b3\u03b1\u03bd\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae\u03c2 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03bf\u03c3\u03af\u03b1\u03c2. \u03a4\u03b1 \u03a4regs \u03b1\u03c3\u03ba\u03bf\u03cd\u03bd \u03c4\u03b7 \u03b4\u03c1\u03ac\u03c3\u03b7 \u03c4\u03bf\u03c5\u03c2 \u03bc\u03ad\u03c3\u03c9 \u03ac\u03bc\u03b5\u03c3\u03b7\u03c2 \u03b5\u03c0\u03b1\u03c6\u03ae\u03c2 \u03ae\/\u03ba\u03b1\u03b9 \u03bc\u03ad\u03c3\u03c9 \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae\u03c2 \u03ba\u03c5\u03c4\u03bf\u03ba\u03b9\u03bd\u03ce\u03bd. \u0393\u03b9\u03b1 \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03ac \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03bf\u03cd\u03bd \u03bc\u03ad\u03c3\u03c9 \u03c4\u03bf\u03c5 TCR \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03bf\u03c0\u03cc\u03c4\u03b5 \u03c0\u03bf\u03bb\u03bb\u03bf\u03af \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03ad\u03c2 \u03b4\u03ad\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c0\u03c9\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03b1\u03bb\u03c4\u03b9\u03ba\u03ae \u03c4\u03bf\u03c5\u03c2 \u03b4\u03c1\u03ac\u03c3\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03b1\u03c1\u03b1\u03af\u03c4\u03b7\u03c4\u03b7 \u03b7 \u03c4\u03b1\u03c5\u03c4\u03cc\u03c7\u03c1\u03bf\u03bd\u03b7 \u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 Tregs-APC-CD4 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd (23) \u03bc\u03b5 \u03c4\u03b1 APC \u03bd\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c1\u03cc\u03bb\u03bf \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c0\u03bb\u03b1\u03c4\u03c6\u03cc\u03c1\u03bc\u03b1\u03c2.<\/li>\n
    2. \u03a4\u03b1 Th17 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03bf\u03cd\u03bd \u03bc\u03b9\u03b1 \u03c0\u03c1\u03bf\u03c3\u03c6\u03ac\u03c4\u03c9\u03c2 \u03b1\u03bd\u03b1\u03ba\u03b1\u03bb\u03c5\u03c6\u03b8\u03b5\u03af\u03c3\u03b1 \u03c5\u03c0\u03bf\u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b1 CD4 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03c5\u03bd IL-17 \u03ba\u03b1\u03b9 \u0399L-22 (24) \u03ba\u03b1\u03b9 \u03c6\u03ad\u03c1\u03bf\u03c5\u03bd \u03c4\u03b1 \u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03b1 \u03b5\u03c0\u03b9\u03c6\u03b1\u03bd\u03b5\u03af\u03b1\u03c2: T-cell Receptor (TCR), CD3, CD4 \u03ba\u03b1\u03b9 CCR6. \u039f \u03bc\u03b5\u03c4\u03b1\u03b3\u03c1\u03b1\u03c6\u03b9\u03ba\u03cc\u03c2 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1\u03c2 ROR\u03b3t (retinoid related orphan receptor) \u03ad\u03c7\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03c1\u03cc\u03bb\u03bf \u03c3\u03c4\u03bf\u03bd \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03c4\u03b7\u03c2 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03ae\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03b5\u03bd\u03ce \u03b7 \u0399L-23, \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03ac\u03b3\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc APC, \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03b1\u03c1\u03b1\u03af\u03c4\u03b7\u03c4\u03b7 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03c4\u03bf\u03c5\u03c2 \u03b5\u03c5\u03bf\u03b4\u03ce\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03ac\u03bb\u03bb\u03c9\u03bd \u03ba\u03c5\u03c4\u03bf\u03ba\u03b9\u03bd\u03ce\u03bd \u03ba\u03b1\u03b9 \u03b1\u03c5\u03be\u03ac\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03bf\u03bd ROR\u03b3t (25). \u0395\u03b9\u03b4\u03b9\u03ba\u03cc\u03c4\u03b5\u03c1\u03b1, \u03bf\u03b9 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2 TGF-b \u03ba\u03b1\u03b9 IL-6 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd \u03c4\u03bf\u03bd ROR\u03b3t \u03c0\u03bf\u03c5 \u03b2\u03c1\u03af\u03c3\u03ba\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b1 CD4 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd \u03c0\u03c1\u03bf\u03c2 \u03c4\u03b7\u03bd \u03a4h17 \u03ba\u03b1\u03c4\u03b5\u03cd\u03b8\u03c5\u03bd\u03c3\u03b7 (26). \u03a4\u03b1 \u03a4h 17 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03c4\u03b9\u03ba\u03cc \u03c1\u03cc\u03bb\u03bf \u03c3\u03c4\u03b7\u03bd \u03ba\u03b9\u03bd\u03b7\u03c4\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7, \u03b5\u03c0\u03b9\u03c3\u03c4\u03c1\u03ac\u03c4\u03b5\u03c5\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03bf\u03c5\u03b4\u03b5\u03c4\u03b5\u03c1\u03cc\u03c6\u03b9\u03bb\u03c9\u03bd \u03b5\u03bd\u03ce \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03b5\u03c0\u03ac\u03b3\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03ad\u03ba\u03ba\u03c1\u03b9\u03c3\u03b7 \u03ba\u03c5\u03c4\u03bf\u03ba\u03b9\u03bd\u03ce\u03bd \u03b1\u03c0\u03cc \u03ac\u03bb\u03bb\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 (\u03c0.\u03c7. APC), \u03ad\u03c7\u03bf\u03bd\u03c4\u03b1\u03c2 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c0\u03c1\u03bf\u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ce\u03b4\u03b7 \u03b4\u03c1\u03ac\u03c3\u03b7. \u0397 IL-22 \u03ad\u03c7\u03b5\u03b9 \u03ba\u03b1\u03b9 \u03b1\u03c5\u03c4\u03ae \u03c0\u03c1\u03bf\u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ce\u03b4\u03b7 \u03b4\u03c1\u03ac\u03c3\u03b7 \u03b1\u03bd \u03ba\u03b1\u03b9 \u03ad\u03c7\u03b5\u03b9 \u03b1\u03bd\u03b1\u03c6\u03b5\u03c1\u03b8\u03b5\u03af \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03c3\u03c4\u03b1\u03c4\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03b4\u03c1\u03ac\u03c3\u03b7 \u03c3\u03c4\u03b1 \u03b5\u03c0\u03b9\u03b8\u03b7\u03bb\u03b9\u03b1\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 (27-30).<\/li>\n
    3. \u03a4\u03b1 \u03a4h22 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03bf\u03cd\u03bd \u03b1\u03ba\u03cc\u03bc\u03b1 \u03bc\u03b9\u03b1 \u03c5\u03c0\u03bf\u03bf\u03bc\u03ac\u03b4\u03b1 \u03c4\u03c9\u03bd T \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c0\u03bf\u03c5 \u03c6\u03ad\u03c1\u03bf\u03c5\u03bd \u03c4\u03b1 \u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03b1 TCR, CD3, CD4, CCR6, CCR4 \u03ba\u03b1\u03b9 CCR10 \u03ba\u03b1\u03b9 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03c5\u03bd IL-22 \u03b1\u03bb\u03bb\u03ac \u03cc\u03c7\u03b9 IL-17. \u0397 IL-22 \u03ad\u03c7\u03b5\u03b9 \u03c0\u03c1\u03bf\u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ce\u03b4\u03b7 \u03b4\u03c1\u03ac\u03c3\u03b7 \u03c3\u03b5 \u03c3\u03c5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b1 \u03bc\u03b5 \u03c4\u03b7\u03bd IL-17, \u03c4\u03bf\u03bd TNF-\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd IFN-\u03b3 \u03b1\u03bb\u03bb\u03ac \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c0\u03b1\u03af\u03be\u03b5\u03b9 \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03c3\u03c4\u03b1\u03c4\u03b5\u03c5\u03c4\u03b9\u03ba\u03cc \u03c1\u03cc\u03bb\u03bf \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b5\u03c0\u03b9\u03b8\u03b7\u03bb\u03b9\u03b1\u03ba\u03ce\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd (27-30).<\/li>\n
    4. T\u03b1 \u03a4fh \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c3\u03c5\u03bd\u03b9\u03c3\u03c4\u03bf\u03cd\u03bd \u03ad\u03bd\u03b1 \u03c0\u03c1\u03bf\u03c3\u03c6\u03ac\u03c4\u03c9\u03c2 \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03b1\u03c6\u03ad\u03bd \u03c5\u03c0\u03bf\u03b5\u03af\u03b4\u03bf\u03c2 \u03a4 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd (CD4+CXCR5+ICOShigh \u03ae CD4+CXCR5+PD-1high) \u03ba\u03b1\u03b9 \u03b7 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5\u03c2 \u03c3\u03c5\u03bd\u03c4\u03b5\u03bb\u03b5\u03af\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7 \u03c3\u03c5\u03bc\u03b2\u03bf\u03bb\u03ae \u03c4\u03bf\u03c5 \u03bc\u03b5\u03c4\u03b1\u03b3\u03c1\u03b1\u03c6\u03b9\u03ba\u03bf\u03cd \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1 \u0392cl-6 \u03c4\u03bf\u03bd \u03bf\u03c0\u03bf\u03af\u03bf \u03b5\u03ba\u03c6\u03c1\u03ac\u03b6\u03bf\u03c5\u03bd (31). \u03a4\u03b1 \u03a4fh \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b4\u03cd\u03bd\u03b1\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03bc\u03b5\u03c4\u03b1\u03bd\u03b1\u03c3\u03c4\u03b5\u03cd\u03bf\u03c5\u03bd \u03c3\u03b5 \u03bb\u03b5\u03bc\u03c6\u03bf\u03b5\u03b9\u03b4\u03ae \u03ba\u03ad\u03bd\u03c4\u03c1\u03b1 (germinal centers) \u03bc\u03ad\u03c3\u03c9 \u03c4\u03c9\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03c9\u03bd \u03c0\u03bf\u03c5 \u03c6\u03ad\u03c1\u03bf\u03c5\u03bd (CXCR5), \u03b7 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03c9\u03bd \u03bf\u03c0\u03bf\u03af\u03c9\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03b1\u03c1\u03b1\u03af\u03c4\u03b7\u03c4\u03b7 \u03c4\u03cc\u03c3\u03bf \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03bc\u03b5\u03c4\u03b1\u03bd\u03ac\u03c3\u03c4\u03b5\u03c5\u03c3\u03b7 \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03c4\u03b7 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03c4\u03bf\u03c5\u03c2. \u03a3\u03c5\u03bc\u03bc\u03b5\u03c4\u03ad\u03c7\u03bf\u03c5\u03bd \u03c3\u03c4\u03b7 \u03c1\u03cd\u03b8\u03bc\u03b9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03bd\u03c4\u03b9\u03b3\u03bf\u03bd\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03bf\u03c3\u03af\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae\u03c2 \u03b1\u03c0\u03ac\u03bd\u03c4\u03b7\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd \u0392 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd (32) \u03bc\u03ad\u03c3\u03c9 \u03ba\u03c5\u03c4\u03bf\u03ba\u03b9\u03bd\u03ce\u03bd \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03c5\u03bd (\u03ba\u03c5\u03c1\u03af\u03c9\u03c2 IL-21) \u03ba\u03b1\u03b8\u03ce\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03c9\u03bd \u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03c9\u03bd \u03b5\u03c0\u03b9\u03c6\u03b1\u03bd\u03b5\u03af\u03b1\u03c2 \u03c0\u03bf\u03c5 \u03c6\u03ad\u03c1\u03bf\u03c5\u03bd.
      \n<\/b><\/li>\n<\/ol>\n
      2.2. \u039c\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03af \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03bf\u03c7\u03ae\u03c2 \u03ba\u03b1\u03b9 \u03b4\u03b9\u03b1\u03c6\u03c5\u03b3\u03ae\u03c2 \u03b1\u03c0\u03cc \u03b1\u03c5\u03c4\u03ae\u03bd.<\/b><\/h5>\n

      \u0395\u03b4\u03ce \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03af \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03c3\u03c4\u03b1\u03c4\u03b5\u03cd\u03bf\u03c5\u03bd \u03c4\u03bf\u03bd \u03bf\u03c1\u03b3\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd (T effectors) \u03b1\u03bd\u03c4\u03b9\u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ce\u03bd \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03c9\u03bd \u03c4\u03bf\u03c5 \u03af\u03b4\u03b9\u03bf\u03c5 \u03c4\u03bf\u03c5 \u03bf\u03c1\u03b3\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03cd (\u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03b1). \u0394\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ae \u03c3\u03b5 \u03ad\u03bd\u03b1\u03bd \u03ae \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf\u03c5\u03c2 \u03b1\u03c0\u03cc \u03b1\u03c5\u03c4\u03bf\u03cd\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03cd\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bf\u03b4\u03b7\u03b3\u03ae\u03c3\u03b5\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03bf\u03c3\u03af\u03b1\u03c2. \u03a4\u03ad\u03c4\u03bf\u03b9\u03bf\u03b9 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03af \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03ba\u03b5\u03bd\u03c4\u03c1\u03b9\u03ba\u03ae (\u03c3\u03c4\u03bf \u03b8\u03cd\u03bc\u03bf) \u03ba\u03b1\u03b9 \u03c0\u03b5\u03c1\u03b9\u03c6\u03b5\u03c1\u03b9\u03ba\u03ae \u03b1\u03bd\u03bf\u03c7\u03ae (central and peripheral tolerance) \u03ba\u03b1\u03b8\u03ce\u03c2 \u03ba\u03b1\u03b9 \u03b7 \u03b1\u03bd\u03ad\u03c1\u03b3\u03b9\u03b1 \u03c4\u03c9\u03bd \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ce\u03bd \u03ba\u03bb\u03ce\u03bd\u03c9\u03bd \u03c4\u03c9\u03bd \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd (clonal anergy). \u039f\u03b9 \u03c0\u03c1\u03ce\u03c4\u03b5\u03c2 \u03b4\u03cd\u03bf \u03c3\u03c5\u03bd\u03c4\u03b5\u03bb\u03bf\u03cd\u03bd \u03c3\u03c4\u03b7\u03bd \u03b5\u03be\u03ac\u03bb\u03b5\u03b9\u03c8\u03b7 \u03c4\u03c9\u03bd \u03b1\u03bd\u03ce\u03c1\u03b9\u03bc\u03c9\u03bd \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ce\u03bd \u03ba\u03bb\u03ce\u03bd\u03c9\u03bd, \u03bb\u03cc\u03b3\u03c9 \u03b1\u03c0\u03bf\u03c5\u03c3\u03af\u03b1\u03c2 \u03c3\u03c5\u03bd-\u03b4\u03b9\u03b5\u03b3\u03b5\u03c1\u03c4\u03b9\u03ba\u03bf\u03cd \u03c3\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2 (\u03c0\u03c7. \u03927.1 \u03ae \u03927.2 \u03bc\u03b5 CD28) \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u03b5\u03c0\u03b1\u03c6\u03ae \u03bc\u03b5 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03b1. \u0397 \u03b1\u03bd\u03ad\u03c1\u03b3\u03b9\u03b1 \u03b5\u03c0\u03b9\u03c4\u03c5\u03b3\u03c7\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b1\u03bd \u03ce\u03c1\u03b9\u03bc\u03b1 \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03ad\u03c1\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b5\u03c0\u03b1\u03c6\u03ae \u03bc\u03b5 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03b1 \u03b1\u03c0\u03bf\u03c5\u03c3\u03af\u03b1 \u03c3\u03c5\u03bd-\u03b4\u03b9\u03b5\u03b3\u03b5\u03c1\u03c4\u03b9\u03ba\u03bf\u03cd \u03c3\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bc\u03b2\u03ac\u03bb\u03bb\u03b5\u03b9 \u03c3\u03c4\u03b7\u03bd \u03c5\u03c0\u03bf\u03c1\u03c1\u03cd\u03b8\u03bc\u03b9\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03ae \u03b1\u03bd\u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03ae \u03c4\u03bf\u03c5\u03c2 (33). \u03a3\u03b5 \u03c0\u03c1\u03ce\u03c4\u03bf \u03c3\u03c4\u03ac\u03b4\u03b9\u03bf \u03c4\u03b1 \u03b5\u03bd \u03b4\u03c5\u03bd\u03ac\u03bc\u03b5\u03b9 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03a4 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03c1\u03ad\u03c6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf \u03b8\u03cd\u03bc\u03bf \u03bc\u03ad\u03c3\u03c9 \u03c4\u03c9\u03bd \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03ce\u03bd \u03c4\u03b7\u03c2 \u03ba\u03b5\u03bd\u03c4\u03c1\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03bf\u03c7\u03ae\u03c2. \u03a3\u03c4\u03bf \u03b4\u03b5\u03cd\u03c4\u03b5\u03c1\u03bf \u03c3\u03c4\u03ac\u03b4\u03b9\u03bf \u03c4\u03b1 \u03bb\u03af\u03b3\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c0\u03bf\u03c5 \u03c0\u03b9\u03b8\u03b1\u03bd\u03ce\u03c2 \u03b4\u03b9\u03ad\u03c6\u03c5\u03b3\u03b1\u03bd \u03c4\u03b7\u03c2 \u03ba\u03b5\u03bd\u03c4\u03c1\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03bf\u03c7\u03ae\u03c2 \u03ba\u03b1\u03b9 \u03bc\u03b5\u03c4\u03b1\u03bd\u03ac\u03c3\u03c4\u03b5\u03c5\u03c3\u03b1\u03bd \u03c3\u03c4\u03b7\u03bd \u03c0\u03b5\u03c1\u03b9\u03c6\u03ad\u03c1\u03b5\u03b9\u03b1 \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03ad\u03c3\u03c9 \u03c4\u03c9\u03bd \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03ce\u03bd \u03c4\u03b7\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c6\u03b5\u03c1\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03bf\u03c7\u03ae\u03c2 (\u03b1\u03bd\u03ad\u03c1\u03b3\u03b9\u03b1, \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03b1\u03c0\u03cc \u03c4\u03b1 Tregs).<\/p>\n

      \u0397 \u03b1\u03c0\u03bf\u03bc\u03cc\u03bd\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03bf\u03c5 AIRE (autoimmune regulator), \u03c5\u03c0\u03b5\u03cd\u03b8\u03c5\u03bd\u03bf\u03c5 \u03b3\u03b9\u03b1 \u03c4\u03bf \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03bf \u03c0\u03bf\u03bb\u03c5\u03b1\u03b4\u03b5\u03bd\u03b9\u03ba\u03cc \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf \u03c4\u03cd\u03c0\u03bf\u03c5 1, \u03ad\u03c1\u03b9\u03be\u03b5 \u03bd\u03ad\u03bf \u03c6\u03c9\u03c2 \u03c3\u03c4\u03b7 \u03b8\u03b5\u03ce\u03c1\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03ba\u03b5\u03bd\u03c4\u03c1\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03bf\u03c7\u03ae\u03c2 \u03c9\u03c2 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03bf\u03cd \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03c4\u03b9\u03ba\u03bf\u03cd \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03cd \u03c4\u03b7\u03c2 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03bf\u03c3\u03af\u03b1\u03c2. \u0397 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 \u0391\u0399R\u0395 \u03b5\u03ba\u03c6\u03c1\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c3\u03b5 \u03b5\u03c0\u03b9\u03b8\u03b7\u03bb\u03b9\u03b1\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c4\u03bf\u03c5 \u03bc\u03c5\u03b5\u03bb\u03bf\u03cd \u03c4\u03bf\u03c5 \u03b8\u03cd\u03bc\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03bc\u03bf\u03bd\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1-\u03b4\u03b5\u03bd\u03b4\u03c1\u03b9\u03c4\u03b9\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c0\u03bf\u03c5 \u03b5\u03bd\u03c4\u03bf\u03c0\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b1\u03c5\u03c4\u03cc\u03bd. \u039c\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c3\u03b5 \u03c0\u03bf\u03bd\u03c4\u03af\u03ba\u03b9\u03b1 \u03c3\u03c4\u03b1 \u03bf\u03c0\u03bf\u03af\u03b1 \u03b1\u03c0\u03bf\u03c5\u03c3\u03b9\u03ac\u03b6\u03b5\u03b9 \u03c4\u03bf \u0391\u0399RE \u03ad\u03b4\u03b5\u03b9\u03be\u03b1\u03bd \u03c0\u03bb\u03ae\u03c1\u03b7 \u03b1\u03bd\u03b9\u03ba\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b5\u03be\u03ac\u03bb\u03b5\u03b9\u03c8\u03b7\u03c2 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03c9\u03bd \u03bf\u03c1\u03b3\u03b1\u03bd\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c3\u03c4\u03bf \u03b8\u03cd\u03bc\u03bf. \u0397 \u03b1\u03bd\u03b1\u03ba\u03ac\u03bb\u03c5\u03c8\u03b7 \u03c0\u03c9\u03c2 \u03b7 \u03b8\u03c5\u03c1\u03b5\u03bf\u03c3\u03c6\u03b1\u03b9\u03c1\u03af\u03bd\u03b7 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03ba\u03c6\u03c1\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf \u03bc\u03c5\u03b5\u03bb\u03cc \u03c4\u03bf\u03c5 \u03b8\u03cd\u03bc\u03bf\u03c5, \u03bf\u03b4\u03ae\u03b3\u03b7\u03c3\u03b5 \u03c3\u03c4\u03b7\u03bd \u03c5\u03c0\u03cc\u03b8\u03b5\u03c3\u03b7 \u03c0\u03c9\u03c2 \u03b7 \u03c3\u03c5\u03bd\u03b5\u03b9\u03c3\u03c6\u03bf\u03c1\u03ac \u03c4\u03bf\u03c5 AIRE \u03c3\u03c4\u03b7\u03bd \u03b1\u03bd\u03bf\u03c7\u03ae \u03c4\u03c9\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03c9\u03bd \u03af\u03c3\u03c9\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae. \u039c\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 AIRE \u03af\u03c3\u03c9\u03c2 \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03b5 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 Tg \u03ba\u03b1\u03b9 \u03ac\u03bb\u03bb\u03c9\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03c9\u03bd \u03c3\u03c4\u03bf \u03b8\u03cd\u03bc\u03bf \u03c0\u03bf\u03c5 \u03c4\u03b5\u03bb\u03b9\u03ba\u03ac \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03c4\u03b7 \u03b4\u03b9\u03b1\u03c6\u03c5\u03b3\u03ae \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ce\u03bd \u03a4 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c3\u03c4\u03b7\u03bd \u03c0\u03b5\u03c1\u03b9\u03c6\u03ad\u03c1\u03b5\u03b9\u03b1 (34,35).<\/p>\n

      \u0391\u03c0\u03cc \u03c4\u03b7\u03bd \u03ac\u03bb\u03bb\u03b7 \u03c0\u03bb\u03b5\u03c5\u03c1\u03ac \u03ba\u03b1\u03b9 \u03b7 \u03c0\u03b5\u03c1\u03b9\u03c6\u03b5\u03c1\u03b9\u03ba\u03ae \u03b1\u03bd\u03bf\u03c7\u03ae \u03c3\u03c5\u03bc\u03b2\u03ac\u03bb\u03bb\u03b5\u03b9 \u03c3\u03c4\u03b7\u03bd \u03c0\u03c1\u03bf\u03c3\u03c4\u03b1\u03c3\u03af\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03c9\u03bd. \u039c\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03c0\u03b9\u03c4\u03b5\u03c5\u03c7\u03b8\u03b5\u03af \u03bc\u03ad\u03c3\u03c9 \u03c4\u03b7\u03c2 \u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd APC \u03bc\u03b5 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03a4 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c0\u03bf\u03c5 \u03c6\u03ad\u03c1\u03bf\u03c5\u03bd \u03c4\u03bf \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03b1\u03bb\u03c4\u03b9\u03ba\u03cc \u03bc\u03cc\u03c1\u03b9\u03bf CTLA-4. \u0391\u03ba\u03cc\u03bc\u03b1 \u03c4\u03cc\u03c3\u03bf \u03b7 \u03b4\u03b9\u03b1\u03bb\u03c5\u03c4\u03ae \u03bc\u03bf\u03c1\u03c6\u03ae sCTLA-4, \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03bd\u03ad\u03b1 \u03bc\u03cc\u03c1\u03b9\u03b1 PD-1 \u03ba\u03b1\u03b9 PD-L1, PD-L2 \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c0\u03c9\u03c2 \u03b4\u03b9\u03b1\u03b4\u03c1\u03b1\u03bc\u03b1\u03c4\u03af\u03b6\u03bf\u03c5\u03bd \u03c3\u03c0\u03bf\u03c5\u03b4\u03b1\u03af\u03bf \u03c1\u03cc\u03bb\u03bf \u03c3\u03c4\u03bf\u03bd \u03c0\u03b5\u03c1\u03b9\u03bf\u03c1\u03b9\u03c3\u03bc\u03cc \u03c0\u03b9\u03b8\u03b1\u03bd\u03ce\u03bd \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ce\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd(18,19,20). \u03a0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03b2\u03ad\u03b2\u03b1\u03b9\u03b1 \u03bd\u03b1 \u03c3\u03b7\u03bc\u03b5\u03b9\u03c9\u03b8\u03b5\u03af \u03c0\u03c9\u03c2 \u03b7 \u03c3\u03c5\u03bd\u03b5\u03b9\u03c3\u03c6\u03bf\u03c1\u03ac \u03c4\u03c9\u03bd \u03c0\u03b1\u03c1\u03b1\u03c0\u03ac\u03bd\u03c9, \u03c0\u03c1\u03bf\u03c3\u03c6\u03ac\u03c4\u03c9\u03c2 \u03b1\u03bd\u03b1\u03ba\u03b1\u03bb\u03c5\u03c6\u03b8\u03ad\u03bd\u03c4\u03c9\u03bd, \u03bc\u03bf\u03c1\u03af\u03c9\u03bd \u03c3\u03c4\u03b7\u03bd \u03c0\u03b5\u03c1\u03b9\u03c6\u03b5\u03c1\u03b9\u03ba\u03ae \u03b1\u03bd\u03bf\u03c7\u03ae \u03b4\u03b5\u03bd \u03ad\u03c7\u03b5\u03b9 \u03c0\u03bb\u03ae\u03c1\u03c9\u03c2 \u03b4\u03b9\u03b5\u03c5\u03ba\u03c1\u03b9\u03bd\u03b9\u03c3\u03c4\u03b5\u03af \u03ba\u03b1\u03b9 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c0\u03b5\u03c1\u03b1\u03b9\u03c4\u03ad\u03c1\u03c9 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7.<\/p>\n

      3. \u0391\u03b9\u03c4\u03b9\u03bf\u03c0\u03b1\u03b8\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae\u03c2 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03bf\u03c3\u03af\u03b1\u03c2 <\/b><\/h4>\n
      3.1. \u0393\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03bf\u03af \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2<\/b><\/h5>\n

      \u0397 \u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c0\u03b5\u03c1\u03b9\u03b2\u03b1\u03bb\u03bb\u03bf\u03bd\u03c4\u03b9\u03ba\u03ce\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03cc\u03bd\u03c4\u03c9\u03bd \u03bc\u03b5 \u03c4\u03bf \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03cc \u03c5\u03c0\u03cc\u03b2\u03b1\u03b8\u03c1\u03bf \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03c9\u03bd \u03b1\u03c4\u03cc\u03bc\u03c9\u03bd \u03b4\u03b9\u03b5\u03ba\u03b4\u03b9\u03ba\u03b5\u03af \u03ba\u03cd\u03c1\u03b9\u03bf \u03c1\u03cc\u03bb\u03bf \u03c3\u03c4\u03b7\u03bd \u03c0\u03b1\u03b8\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 \u0398\u0391. \u038c\u03c3\u03bf\u03bd \u03b1\u03c6\u03bf\u03c1\u03ac \u03c3\u03c4\u03b7 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03c0\u03c1\u03bf\u03b4\u03b9\u03ac\u03b8\u03b5\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 \u0398\u0391, \u03ad\u03c7\u03bf\u03c5\u03bd \u03b5\u03bc\u03c0\u03bb\u03b1\u03ba\u03b5\u03af \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 \u03c4\u03bf\u03c5 \u03bc\u03b5\u03af\u03b6\u03bf\u03bd\u03bf\u03c2 \u03c3\u03c5\u03bc\u03c0\u03bb\u03ad\u03b3\u03bc\u03b1\u03c4\u03bf\u03c2 \u03b9\u03c3\u03c4\u03bf\u03c3\u03c5\u03bc\u03b2\u03b1\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 (MHC), \u03c0\u03bf\u03c5 \u03b8\u03b5\u03c9\u03c1\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03c0\u03b9\u03bf \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac, \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03bc\u03b7-MHC \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1. \u039c\u03b5\u03b3\u03ac\u03bb\u03bf\u03c2 \u03b1\u03c1\u03b9\u03b8\u03bc\u03cc\u03c2 \u03bc\u03b5\u03bb\u03b5\u03c4\u03ce\u03bd \u03ad\u03c7\u03b5\u03b9 \u03c3\u03c5\u03c3\u03c7\u03b5\u03c4\u03af\u03c3\u03b5\u03b9 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03b5\u03b8\u03bd\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03b1\u03bb\u03bb\u03ae\u03bb\u03bf\u03c5\u03c2 \u03c4\u03bf\u03c5 MHC \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03bf\u03c5 \u03bc\u03b5 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7\u03c2 HT \u03ba\u03b1\u03b9 GD. \u0391\u03ba\u03cc\u03bc\u03b1, \u03c0\u03bf\u03bb\u03c5\u03bc\u03bf\u03c1\u03c6\u03b9\u03c3\u03bc\u03bf\u03af \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03c9\u03bd \u03cc\u03c0\u03c9\u03c2 \u03c4\u03b1 CTLA-4, FCRL3, CD40, PTPN22, CD25, TSHR, Tg, SCGB3A2 \u03ba\u03b1\u03b9 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03c9\u03bd \u03c0\u03bf\u03c5 \u03ba\u03c9\u03b4\u03b9\u03ba\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd \u03c0\u03c1\u03bf\u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ce\u03b4\u03b5\u03b9\u03c2 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03ba\u03af\u03bd\u03b5\u03c2 \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03c3\u03c5\u03bd\u03b4\u03c1\u03ac\u03bc\u03bf\u03c5\u03bd \u03c3\u03c4\u03b7\u03bd \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u0398\u0391.<\/p>\n

      \u0397 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1 \u03c4\u03bf\u03c5 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03bf\u03cd \u03c5\u03c0\u03bf\u03b2\u03ac\u03b8\u03c1\u03bf\u03c5 \u03c3\u03c4\u03b7\u03bd \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u0398\u0391 \u03b4\u03b9\u03b1\u03c0\u03b9\u03c3\u03c4\u03ce\u03b8\u03b7\u03ba\u03b5 \u03b1\u03c1\u03c7\u03b9\u03ba\u03ac \u03b1\u03c0\u03cc \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03b4\u03b9\u03b4\u03cd\u03bc\u03c9\u03bd \u03bf\u03b9 \u03bf\u03c0\u03bf\u03af\u03b5\u03c2 \u03ba\u03b1\u03c4\u03ad\u03b3\u03c1\u03b1\u03c8\u03b1\u03bd \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03bf \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03c4\u03b1\u03c5\u03c4\u03cc\u03c7\u03c1\u03bf\u03bd\u03b7\u03c2 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1\u03c2 (concordance) \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b1 \u03b4\u03cd\u03bf \u03b1\u03b4\u03ad\u03bb\u03c6\u03b9\u03b1 \u03c3\u03b5 \u03bc\u03bf\u03bd\u03bf\u03b6\u03c5\u03b3\u03c9\u03c4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03c3\u03b5 \u03c3\u03c7\u03ad\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03bf\u03c5\u03c2 \u03b4\u03b9\u03b6\u03c5\u03b3\u03c9\u03c4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03b4\u03b9\u03b4\u03cd\u03bc\u03bf\u03c5\u03c2. \u03a9\u03c3\u03c4\u03cc\u03c3\u03bf \u03b1\u03ba\u03cc\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03bc\u03bf\u03bd\u03bf\u03b6\u03c5\u03b3\u03c9\u03c4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03b4\u03b9\u03b4\u03cd\u03bc\u03bf\u03c5\u03c2 \u03c4\u03bf \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03b1\u03c5\u03c4\u03cc \u03b4\u03b5\u03bd \u03be\u03b5\u03c0\u03b5\u03c1\u03bd\u03bf\u03cd\u03c3\u03b5 \u03c4\u03bf 50% (36) \u03c0\u03b1\u03c1\u03ad\u03c7\u03bf\u03bd\u03c4\u03b1\u03c2 \u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03c3\u03c5\u03bc\u03bc\u03ad\u03c4\u03bf\u03c7\u03b7 \u03ba\u03b1\u03b9 \u03c0\u03b5\u03c1\u03b9\u03b2\u03b1\u03bb\u03bb\u03bf\u03bd\u03c4\u03b9\u03ba\u03ce\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03cc\u03bd\u03c4\u03c9\u03bd. \u03a0\u03b5\u03c1\u03b1\u03b9\u03c4\u03ad\u03c1\u03c9 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c3\u03b5 \u03b4\u03b9\u03b4\u03cd\u03bc\u03bf\u03c5\u03c2 \u03ad\u03b4\u03b5\u03b9\u03be\u03b1\u03bd \u03c0\u03c9\u03c2 \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 80% \u03c4\u03bf\u03c5 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u03b3\u03b9\u03b1 \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 \u0398\u0391 \u03bf\u03c6\u03b5\u03af\u03bb\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2 \u03b5\u03bd\u03ce \u03bf\u03b9 \u03c0\u03b5\u03c1\u03b9\u03b2\u03b1\u03bb\u03bb\u03bf\u03bd\u03c4\u03b9\u03ba\u03bf\u03af \u03ba\u03b1\u03b9 \u03bb\u03bf\u03b9\u03c0\u03bf\u03af \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2 \u03c3\u03c5\u03bd\u03b5\u03b9\u03c3\u03c6\u03ad\u03c1\u03bf\u03c5\u03bd \u03c3\u03c4\u03bf 20% (36,37).<\/p>\n

      \u03a3\u03b5 \u03b4\u03cd\u03bf \u03b5\u03bd\u03b4\u03b9\u03b1\u03c6\u03ad\u03c1\u03bf\u03c5\u03c3\u03b5\u03c2 \u03b1\u03bd\u03b1\u03c3\u03ba\u03bf\u03c0\u03ae\u03c3\u03b5\u03b9\u03c2 \u03c4\u03bf\u03c5 Tomer \u03ba\u03b1\u03b9 \u03c4\u03c9\u03bd Brand & Gough (38,39) o\u03b9 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03bf\u03b9 \u03bf\u03c0\u03bf\u03af\u03b5\u03c2 \u03c3\u03c4\u03bf\u03c7\u03b5\u03cd\u03bf\u03c5\u03bd \u03c3\u03c4\u03b7\u03bd \u03b1\u03bd\u03b1\u03b3\u03bd\u03ce\u03c1\u03b9\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c7\u03b1\u03c1\u03c4\u03bf\u03b3\u03c1\u03ac\u03c6\u03b7\u03c3\u03b7 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03c9\u03bd \u03bc\u03b5 \u03c3\u03c5\u03bd\u03b5\u03b9\u03c3\u03c6\u03bf\u03c1\u03ac \u03c3\u03c4\u03b7\u03bd \u03c0\u03c1\u03bf\u03b4\u03b9\u03ac\u03b8\u03b5\u03c3\u03b7 \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7\u03c2 \u0398\u0391, \u03ba\u03b1\u03c4\u03b1\u03c4\u03ac\u03c3\u03c3\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c7\u03c1\u03bf\u03bd\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03c3\u03c4\u03b9\u03c2 \u03b5\u03be\u03ae\u03c2 \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b5\u03c2.<\/p>\n

        \n
      1. \u03a0\u03c1\u03ce\u03b9\u03bc\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7\u03c2 \u03c5\u03c0\u03bf\u03c8\u03ae\u03c6\u03b9\u03c9\u03bd \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03c9\u03bd (<\/b>candidate<\/b> <\/b>gene<\/b> <\/b>analysis<\/b>). <\/b>\u03a3\u03c4\u03b1 \u03c5\u03c0\u03bf\u03c8\u03ae\u03c6\u03b9\u03b1 \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 \u03ba\u03b1\u03c4\u03b1\u03c4\u03ac\u03c3\u03c3\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c5\u03c4\u03ac \u03c0\u03bf\u03c5, \u03bb\u03cc\u03b3\u03c9 \u03c4\u03b7\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2 \u03c4\u03bf\u03c5\u03c2, \u03b8\u03b5\u03c9\u03c1\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c0\u03c9\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03bc\u03c0\u03bb\u03ad\u03ba\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b1\u03b9\u03c4\u03b9\u03bf\u03c0\u03b1\u03b8\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 \u0398\u0391 (\u03c0.\u03c7 \u03c4\u03b1 \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 \u03c0\u03bf\u03c5 \u03ba\u03c9\u03b4\u03b9\u03ba\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd \u03c4\u03b7\u03bd \u03a4PO, Tg, NIS \u03ae \u03c4\u03bf\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03c4\u03b7\u03c2 TSH -\u03a4SHR).<\/li>\n
      2. \u039c\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5 \u03c3\u03cd\u03bd\u03b4\u03b5\u03c3\u03b7\u03c2 \u03c3\u03b5 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03bf \u03b3\u03bf\u03bd\u03b9\u03b4\u03b9\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 (<\/b>whole<\/b>–<\/b>genome<\/b> <\/b>linkage<\/b> <\/b>screening<\/b>).<\/b> \u03a0\u03c1\u03cc\u03ba\u03b5\u03b9\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5 \u03bf\u03bb\u03cc\u03ba\u03bb\u03b7\u03c1\u03bf\u03c5 \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03b9\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 \u03b3\u03b9\u03b1 \u03ba\u03ac\u03b8\u03b5 \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf \u03c0\u03bf\u03c5 \u03b5\u03bc\u03c0\u03bb\u03ad\u03ba\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b1\u03b9\u03c4\u03b9\u03bf\u03c0\u03b1\u03b8\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5. \u03a3\u03c4\u03b9\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03b1\u03c5\u03c4\u03ad\u03c2 \u03b5\u03c0\u03b9\u03c3\u03c4\u03c1\u03b1\u03c4\u03b5\u03cd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bf\u03b9\u03ba\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b5\u03c2 \u03c3\u03c4\u03b9\u03c2 \u03bf\u03c0\u03bf\u03af\u03b5\u03c2 \u03b7 \u03bd\u03cc\u03c3\u03bf\u03c2 \u03b5\u03bd\u03b4\u03b7\u03bc\u03b5\u03af. \u03a4\u03b1 \u03bc\u03ad\u03bb\u03b7 \u03c0\u03bf\u03c5 \u03bd\u03bf\u03c3\u03bf\u03cd\u03bd \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03b4\u03b5\u03af\u03ba\u03c4\u03b5\u03c2 \u03b3\u03bf\u03bd\u03bf\u03c4\u03cd\u03c0\u03b9\u03c3\u03b7\u03c2 (genotyping markers) \u03cc\u03bb\u03bf\u03c5 \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03b9\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 \u03b3\u03b9\u03b1 \u03c0\u03bf\u03bb\u03c5\u03bc\u03bf\u03c1\u03c6\u03b9\u03c3\u03bc\u03bf\u03cd\u03c2 \u03b5\u03bd\u03cc\u03c2 \u03bd\u03bf\u03c5\u03ba\u03bb\u03b5\u03bf\u03c4\u03b9\u03b4\u03af\u03bf\u03c5 (SNPs\/single nucleotide polymorphisms) \u03ae \u03bc\u03b9\u03ba\u03c1\u03bf\u03b4\u03bf\u03c1\u03c5\u03c6\u03cc\u03c1\u03bf\u03c5\u03c2 (microsatellites). \u039f\u03b9 \u03c4\u03b5\u03bb\u03b5\u03c5\u03c4\u03b1\u03af\u03bf\u03b9 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03bf\u03cd\u03bd \u03b5\u03c0\u03b1\u03bd\u03b1\u03bb\u03ae\u03c8\u03b5\u03b9\u03c2 \u03b4\u03b9\u03bd\u03bf\u03c5\u03ba\u03bb\u03b5\u03bf\u03c4\u03b9\u03b4\u03af\u03c9\u03bd 1-6 \u03b6\u03b5\u03c5\u03b3\u03ce\u03bd \u03b2\u03ac\u03c3\u03b5\u03c9\u03bd. \u03a4\u03b5\u03c4\u03c1\u03b1\u03ba\u03cc\u03c3\u03b9\u03bf\u03b9 \u03bc\u03b9\u03ba\u03c1\u03bf\u03b4\u03bf\u03c1\u03c5\u03c6\u03bf\u03c1\u03b9\u03ba\u03bf\u03af \u03b4\u03b5\u03af\u03ba\u03c4\u03b5\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c1\u03ba\u03b5\u03c4\u03bf\u03af \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03cc\u03bb\u03bf\u03c5 \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03b9\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 \u03bc\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03bf\u03b9 \u03bc\u03b9\u03ba\u03c1\u03bf\u03b4\u03bf\u03c1\u03c5\u03c6\u03cc\u03c1\u03bf\u03b9 \u03b4\u03b5\u03bd \u03b1\u03c0\u03b1\u03bd\u03c4\u03ce\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b7 \u03b3\u03b5\u03b9\u03c4\u03bd\u03af\u03b1\u03c3\u03b7 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03c4\u03bf\u03c5\u03c2, \u03c3\u03b5 \u03b1\u03bd\u03c4\u03af\u03b8\u03b5\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03bf\u03c5\u03c2 SNPs \u03c0\u03bf\u03c5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03bf\u03bb\u03cd \u03c3\u03c5\u03c7\u03bd\u03bf\u03af (\u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 \u03ad\u03bd\u03b1\u03c2 \u03ba\u03ac\u03b8\u03b5 300 \u03b6\u03b5\u03cd\u03b3\u03b7 \u03b2\u03ac\u03c3\u03b5\u03c9\u03bd) \u03bf\u03c0\u03cc\u03c4\u03b5 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03cc\u03bb\u03bf\u03c5 \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03b9\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 \u03b1\u03c0\u03b1\u03b9\u03c4\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c0\u03bf\u03bb\u03cd \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf\u03b9 SNP \u03b4\u03b5\u03af\u03ba\u03c4\u03b5\u03c2.<\/li>\n<\/ol>\n

        \u0392\u03b1\u03c3\u03b9\u03ba\u03cc \u03b5\u03c1\u03b3\u03b1\u03bb\u03b5\u03af\u03bf \u03c4\u03c9\u03bd \u03bc\u03b5\u03bb\u03b5\u03c4\u03ce\u03bd \u03b1\u03c5\u03c4\u03ce\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03b7 \u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 \u03c3\u03cd\u03bd\u03b4\u03b5\u03c3\u03b7\u03c2 (linkage analysis) \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c3\u03c4\u03b7\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf \u03cc\u03c4\u03b9 \u03b7 \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b1\u03bd\u03b1\u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03bf\u03cd \u03b4\u03cd\u03bf \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03c9\u03bd \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03cc\u03c3\u03bf \u03c0\u03b9\u03bf \u03ba\u03bf\u03bd\u03c4\u03ac \u03b2\u03c1\u03af\u03c3\u03ba\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c4\u03bf \u03ad\u03bd\u03b1 \u03bc\u03b5 \u03c4\u03bf \u03ac\u03bb\u03bb\u03bf. \u0395\u03c6\u03cc\u03c3\u03bf\u03bd \u03c5\u03c0\u03ac\u03c1\u03be\u03bf\u03c5\u03bd \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1 \u03c3\u03cd\u03bd\u03b4\u03b5\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd SNPs \u03c0\u03bf\u03c5 \u03b1\u03c0\u03b1\u03bd\u03c4\u03ce\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03bc\u03b9\u03b1 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b7 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ae (locus) \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03b9\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 \u03bc\u03b5 \u03c4\u03b7 \u03bc\u03b5\u03bb\u03b5\u03c4\u03ce\u03bc\u03b5\u03bd\u03b7 \u03bd\u03cc\u03c3\u03bf, \u03c4\u03cc\u03c4\u03b5 \u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03c3\u03c5\u03bd\u03b5\u03c7\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03bb\u03b5\u03c0\u03c4\u03bf\u03bc\u03b5\u03c1\u03ae \u03c7\u03b1\u03c1\u03c4\u03bf\u03b3\u03c1\u03ac\u03c6\u03b7\u03c3\u03b7 (fine mapping) \u03c4\u03b7\u03c2 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ae\u03c2 \u03b1\u03c5\u03c4\u03ae\u03c2. \u03a3\u03c4\u03bf\u03c5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c1\u03b9\u03c3\u03bc\u03bf\u03cd\u03c2 \u03c4\u03c9\u03bd \u03bc\u03b5\u03bb\u03b5\u03c4\u03ce\u03bd \u03b1\u03c5\u03c4\u03ce\u03bd \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b7 \u03cd\u03c0\u03b1\u03c1\u03be\u03b7 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ce\u03bd \u03c0\u03b1\u03c1\u03b1\u03bb\u03bb\u03b1\u03b3\u03ce\u03bd, \u03bf \u03bc\u03b9\u03ba\u03c1\u03cc\u03c2 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03b1\u03c1\u03b9\u03b8\u03bc\u03cc\u03c2 \u03b1\u03c4\u03cc\u03bc\u03c9\u03bd \u03ba\u03b1\u03b9 \u03b7 \u03ad\u03bb\u03bb\u03b5\u03b9\u03c8\u03b7 \u03bb\u03b5\u03c0\u03c4\u03bf\u03bc\u03b5\u03c1\u03bf\u03cd\u03c2 \u03bc\u03b5\u03b8\u03bf\u03b4\u03bf\u03bb\u03bf\u03b3\u03af\u03b1\u03c2 \u03b3\u03bf\u03bd\u03bf\u03c4\u03cd\u03c0\u03b9\u03c3\u03b7\u03c2. \u0397 \u03b4\u03b7\u03bc\u03b9\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03bb\u03b5\u03c0\u03c4\u03bf\u03bc\u03b5\u03c1\u03ce\u03bd \u03c7\u03b1\u03c1\u03c4\u03ce\u03bd (linkage maps) \u03c4\u03c9\u03bd \u03bc\u03b9\u03ba\u03c1\u03bf\u03b4\u03bf\u03c1\u03c5\u03c6\u03bf\u03c1\u03b9\u03ba\u03ce\u03bd \u03b4\u03b5\u03b9\u03ba\u03c4\u03ce\u03bd \u03ad\u03b4\u03c9\u03c3\u03b5 \u03bd\u03ad\u03b1 \u03c0\u03bd\u03bf\u03ae \u03c3\u03b5 \u03b1\u03c5\u03c4\u03bf\u03cd \u03c4\u03bf\u03c5 \u03b5\u03af\u03b4\u03bf\u03c5\u03c2 \u03c4\u03b9\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2.<\/p>\n

          \n
        1. \u039c\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c3\u03c5\u03c3\u03c7\u03ad\u03c4\u03b9\u03c3\u03b7\u03c2 \u03c3\u03b5 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03bf \u03b3\u03bf\u03bd\u03b9\u03b4\u03b9\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 (<\/b>genome<\/b>–<\/b>wide<\/b> <\/b>association<\/b> <\/b>studies<\/b>–<\/b>GWAS<\/b>).<\/b> \u03a4\u03b1 \u03c4\u03b5\u03bb\u03b5\u03c5\u03c4\u03b1\u03af\u03b1 \u03ad\u03c4\u03b7 \u03bf\u03b9 GWAS \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03bf\u03cd\u03bd \u03ad\u03bd\u03b1 \u03c0\u03bf\u03bb\u03cd \u03b5\u03c5\u03b1\u03af\u03c3\u03b8\u03b7\u03c4\u03bf \u03b5\u03c1\u03b3\u03b1\u03bb\u03b5\u03af\u03bf \u03bc\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03b1\u03bd\u03b9\u03c7\u03bd\u03b5\u03cd\u03c3\u03bf\u03c5\u03bd \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 \u03c4\u03b1 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c3\u03c5\u03bc\u03b2\u03ac\u03bb\u03bb\u03bf\u03c5\u03bd \u03b1\u03ba\u03cc\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03bc\u03b9\u03ba\u03c1\u03cc\u03c4\u03b5\u03c1\u03bf \u03c4\u03bf\u03c5 5% \u03c3\u03c4\u03b7 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03c0\u03c1\u03bf\u03b4\u03b9\u03ac\u03b8\u03b5\u03c3\u03b7 \u03bc\u03b9\u03b1\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5. \u0391\u03c1\u03c7\u03ae \u03c4\u03c9\u03bd \u03bc\u03b5\u03bb\u03b5\u03c4\u03ce\u03bd \u03b1\u03c5\u03c4\u03ce\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03c3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03b5\u03bd\u03cc\u03c2 \u03b1\u03bb\u03bb\u03b7\u03bb\u03af\u03bf\u03c5 \u03c0.\u03c7. \u0397LA-DR3 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c3\u03b5 \u03c3\u03c7\u03ad\u03c3\u03b7 \u03bc\u03b5 \u03bc\u03b9\u03b1 \u03bf\u03bc\u03ac\u03b4\u03b1 \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5. \u0395\u03ac\u03bd \u03c4\u03bf \u03b1\u03bb\u03bb\u03ae\u03bb\u03b9\u03bf \u03c3\u03c5\u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7 \u03bd\u03cc\u03c3\u03bf \u03b8\u03b1 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c0\u03b9\u03bf \u03c3\u03c5\u03c7\u03bd\u03ac \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2. \u039f\u03b9 GWAS \u03ad\u03b3\u03b9\u03bd\u03b1\u03bd \u03b5\u03c6\u03b9\u03ba\u03c4\u03ad\u03c2 \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7\u03bd \u03bf\u03bb\u03bf\u03ba\u03bb\u03ae\u03c1\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 HapMap Project \u03bc\u03b5 \u03c4\u03bf \u03bf\u03c0\u03bf\u03af\u03bf \u03b5\u03c0\u03b9\u03c4\u03b5\u03cd\u03c7\u03b8\u03b7\u03ba\u03b5 \u03b7 \u03b3\u03bf\u03bd\u03bf\u03c4\u03cd\u03c0\u03b9\u03c3\u03b7 3,5 \u03b5\u03ba. SNPs \u03ba\u03b1\u03b9 \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03ac\u03c6\u03b7\u03ba\u03b5 \u03b7 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03c4\u03bf\u03c5\u03c2 \u03b1\u03bd\u03b9\u03c3\u03bf\u03c1\u03c1\u03bf\u03c0\u03af\u03b1 \u03c3\u03cd\u03bd\u03b4\u03b5\u03c3\u03b7\u03c2 (LD-linkage disequilibrium). H \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1 \u03c4\u03b7\u03c2 LD \u03c3\u03c4\u03b9\u03c2 GWAS \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b7, \u03bc\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03bf \u03bc\u03b5\u03bb\u03b5\u03c4\u03bf\u03cd\u03bc\u03b5\u03bd\u03bf \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf \u03af\u03c3\u03c9\u03c2 \u03b4\u03b5\u03bd \u03ad\u03c7\u03b5\u03b9, \u03b1\u03c5\u03c4\u03cc \u03ba\u03b1\u03b8\u03b5\u03b1\u03c5\u03c4\u03cc, \u03c1\u03cc\u03bb\u03bf \u03c3\u03c4\u03b7\u03bd \u03c0\u03c1\u03bf\u03b4\u03b9\u03ac\u03b8\u03b5\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03bd\u03cc\u03c3\u03bf, \u03cc\u03c3\u03bf \u03b7 \u03c3\u03cd\u03bd\u03b4\u03b5\u03c3\u03ae \u03c4\u03bf\u03c5 \u03bc\u03b5 \u03ba\u03ac\u03c0\u03bf\u03b9\u03bf \u03ac\u03bb\u03bb\u03bf \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf. \u0388\u03c4\u03c3\u03b9 \u03b5\u03bd\u03ce \u03bc\u03ad\u03c7\u03c1\u03b9 \u03c4\u03b7\u03bd \u03b5\u03c0\u03bf\u03c7\u03ae \u03c4\u03c9\u03bd GWAS \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03bd \u03be\u03b5\u03c7\u03c9\u03c1\u03b9\u03c3\u03c4\u03bf\u03af \u03b4\u03b5\u03af\u03ba\u03c4\u03b5\u03c2 \u03b3\u03b9\u03b1 \u03ba\u03ac\u03b8\u03b5 \u03ad\u03bd\u03b1\u03bd SNPs, \u03c0\u03bb\u03ad\u03bf\u03bd \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 tag-SNPs \u03b4\u03b5\u03af\u03ba\u03c4\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03bf \u03ba\u03b1\u03b8\u03ad\u03bd\u03b1\u03c2 \u03b1\u03c6\u03bf\u03c1\u03ac \u03c3\u03b5 \u03bc\u03b9\u03b1 \u03b5\u03c5\u03c1\u03cd\u03c4\u03b5\u03c1\u03b7 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ae LD (LD block). \u0388\u03c7\u03b5\u03b9 \u03b2\u03c1\u03b5\u03b8\u03b5\u03af \u03c0\u03c9\u03c2 \u03c4\u03b1 \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 \u03c0\u03bf\u03c5 \u03b2\u03c1\u03af\u03c3\u03ba\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03bc\u03b9\u03b1 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ae LD \u03c3\u03c0\u03ac\u03bd\u03b9\u03b1 \u03b1\u03bd\u03b1\u03c3\u03c5\u03bd\u03b4\u03c5\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03c4\u03bf\u03c5\u03c2, \u03b5\u03bd\u03ce \u03bf \u03b1\u03bd\u03b1\u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b9\u03bf \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c2 \u03c3\u03c4\u03b7\u03bd \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ad\u03c2 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03c4\u03c9\u03bd LD. \u0388\u03c4\u03c3\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03c6\u03b9\u03ba\u03c4\u03cc\u03c2 \u03bf \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03bf\u03bb\u03cc\u03ba\u03bb\u03b7\u03c1\u03bf\u03c5 \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03b9\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 \u03bc\u03b5 \u03c4\u03b7 \u03c7\u03c1\u03ae\u03c3\u03b7 500000 \u03c4\u03ad\u03c4\u03bf\u03b9\u03c9\u03bd SNPs. \u0388\u03c9\u03c2 \u03c4\u03ce\u03c1\u03b1 \u03c4\u03ad\u03c4\u03bf\u03b9\u03bf\u03c5 \u03b5\u03cd\u03c1\u03bf\u03c5\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03b4\u03b5\u03bd \u03ad\u03c7\u03b5\u03b9 \u03b3\u03af\u03bd\u03b5\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u0398\u0391. \u03a9\u03c3\u03c4\u03cc\u03c3\u03bf \u03c0\u03bf\u03bb\u03cd \u03c0\u03c1\u03cc\u03c3\u03c6\u03b1\u03c4\u03b1 \u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 WTCCC \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b5 14500 SNPs \u03b5\u03bd\u03ce \u03c4\u03bf \u0399mmune chip Project \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03b9 200000 SNPs (40,41,42).<\/li>\n
        2. \u0391\u03bb\u03bb\u03b7\u03bb\u03bf\u03cd\u03c7\u03b9\u03c3\u03b7 \u03c3\u03b5 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03bf \u03b3\u03bf\u03bd\u03b9\u03b4\u03b9\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 (<\/b>whole<\/b>–<\/b>genome<\/b> <\/b>sequencing<\/b>).<\/b> \u03a4\u03bf \u03b5\u03c0\u03cc\u03bc\u03b5\u03bd\u03bf \u03b2\u03ae\u03bc\u03b1 \u03c3\u03c4\u03b9\u03c2 \u03b3\u03bf\u03bd\u03b9\u03b4\u03b9\u03b1\u03ba\u03ad\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03b4\u03b7\u03bc\u03b9\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03ad\u03c4\u03bf\u03b9\u03bc\u03c9\u03bd \u03c0\u03bb\u03b1\u03ba\u03b5\u03c4\u03ce\u03bd (platforms) \u03b1\u03bb\u03bb\u03b7\u03bb\u03bf\u03cd\u03c7\u03b9\u03c3\u03b7\u03c2 \u03bf\u03bb\u03cc\u03ba\u03bb\u03b7\u03c1\u03bf\u03c5 \u03c4\u03bf\u03c5 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03b9\u03bd\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03b9\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2. \u0397 \u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03c9\u03bd \u03c0\u03bf\u03c5 \u03b8\u03b1 \u03c0\u03c1\u03bf\u03ba\u03cd\u03c8\u03bf\u03c5\u03bd \u03b1\u03c0\u03cc \u03c4\u03ad\u03c4\u03bf\u03b9\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c0\u03b1\u03c1\u03ad\u03c7\u03b5\u03b9 \u03c0\u03bb\u03b7\u03c1\u03bf\u03c6\u03bf\u03c1\u03af\u03b5\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03bf \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03cc \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7\u03c2 \u03bc\u03b9\u03b1\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5 \u03c3\u03b5 \u03ba\u03ac\u03b8\u03b5 \u03ac\u03c4\u03bf\u03bc\u03bf \u03be\u03b5\u03c7\u03c9\u03c1\u03b9\u03c3\u03c4\u03ac. \u0395\u03c0\u03af\u03c3\u03b7\u03c2 \u03b7 \u03b5\u03c6\u03b1\u03c1\u03bc\u03bf\u03b3\u03ae \u03c4\u03b7\u03c2 \u03c4\u03b5\u03c7\u03bd\u03bf\u03bb\u03bf\u03b3\u03af\u03b1\u03c2 ChIP-Seq (\u03b1\u03bd\u03bf\u03c3\u03bf\u03ba\u03b1\u03b8\u03ae\u03bb\u03c9\u03c3\u03b7 \u03c7\u03c1\u03c9\u03bc\u03b1\u03c4\u03af\u03bd\u03b7\u03c2 \u03c3\u03b5 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03bf \u03b3\u03bf\u03bd\u03b9\u03b4\u03b9\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03bb\u03bb\u03b7\u03bb\u03bf\u03cd\u03c7\u03b9\u03c3\u03b7) \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c0\u03b1\u03c1\u03ad\u03c7\u03b5\u03b9 \u03bb\u03b5\u03c0\u03c4\u03bf\u03bc\u03b5\u03c1\u03ae \u03c7\u03b1\u03c1\u03c4\u03bf\u03b3\u03c1\u03ac\u03c6\u03b7\u03c3\u03b7 \u03cc\u03c3\u03bf\u03bd \u03b1\u03c6\u03bf\u03c1\u03ac \u03c3\u03c4\u03b7\u03bd \u03c0\u03c1\u03cc\u03c3\u03b4\u03b5\u03c3\u03b7 \u03bc\u03b5\u03c4\u03b1\u03b3\u03c1\u03b1\u03c6\u03b9\u03ba\u03ce\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03cc\u03bd\u03c4\u03c9\u03bd \u03c3\u03c4\u03bf \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03cc \u03c5\u03bb\u03b9\u03ba\u03cc \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b5\u03c0\u03b1\u03ba\u03cc\u03bb\u03bf\u03c5\u03b8\u03b7 \u03c1\u03cd\u03b8\u03bc\u03b9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bc\u03b5\u03c4\u03b1\u03b3\u03c1\u03b1\u03c6\u03ae\u03c2 \u03c4\u03bf\u03c5.<\/li>\n<\/ol>\n

          \u03a4\u03b1 \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1, \u03bf\u03b9 \u03c0\u03bf\u03bb\u03c5\u03bc\u03bf\u03c1\u03c6\u03b9\u03c3\u03bc\u03bf\u03af \u03c4\u03c9\u03bd \u03bf\u03c0\u03bf\u03af\u03c9\u03bd \u03ad\u03c7\u03bf\u03c5\u03bd \u03b5\u03bd\u03bf\u03c7\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03b5\u03af \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7 \u03c0\u03c1\u03bf\u03b4\u03b9\u03ac\u03b8\u03b5\u03c3\u03b7\u03c2 \u03b3\u03b9\u03b1 \u0398\u0391, \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03c7\u03c9\u03c1\u03b9\u03c3\u03c4\u03bf\u03cd\u03bd \u03c3\u03b5 \u03c0\u03ad\u03bd\u03c4\u03b5 \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b5\u03c2.<\/p>\n

            \n
          1. \u0393\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 \u03c0\u03bf\u03c5 \u03b5\u03bc\u03c0\u03bb\u03ad\u03ba\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c4\u03c9\u03bd \u03a4 \u03ba\u03b1\u03b9 \u0392 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03bc\u03b5 \u03c4\u03b1 \u0391PC \u03ae \u03b1\u03bb\u03bb\u03b9\u03ce\u03c2 \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae\u03c2 \u03c3\u03cd\u03bd\u03b1\u03c8\u03b7\u03c2 (immunological synapse genes): \u0397LA-DR, CTLA-4, FCRL3, CD40, \u0391\u0399RE, PTPN22, TCR-\u03b2<\/li>\n
          2. \u0393\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03c4\u03b9\u03ba\u03ce\u03bd \u03a4 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd (\u03a4regs): CD25(IL2aR), FOXP3<\/li>\n
          3. \u0393\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03ce\u03bd \u03c4\u03bf\u03c5 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03bf\u03cd\u03c2: Tg, TSHR, \u03a4PO<\/li>\n
          4. \u0393\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 \u03ba\u03c5\u03c4\u03bf\u03ba\u03b9\u03bd\u03ce\u03bd \u03ba\u03b1\u03b9 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03c9\u03bd \u03c4\u03bf\u03c5\u03c2: IL23R, TNF-a, IL-13, IL-3, IL-4, IL-6, IL-17F, IL-1RN<\/li>\n
          5. \u039b\u03bf\u03b9\u03c0\u03ac \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ad\u03ba\u03c5\u03c8\u03b1\u03bd \u03b1\u03c0\u03cc GWAS: SCGB3A2, \u039c\u039c\u0395L1, LPP, BACH2, FGFR1oP, PRICKLE1, 216 kb upstream of TRIB2, 83 kb upstream of ITGAM, CCR6. \u0395\u03c0\u03af\u03c4\u03bf\u03c0\u03bf\u03b9 \u03c3\u03c4\u03b1 \u03c7\u03c1\u03c9\u03bc\u03bf\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03a7q21.1, 22q12.3-13.1, 1q23.2, 9q34.2, 14q32.2, 10q rs6479778, 14q rs12147587, rs2284720.<\/li>\n<\/ol>\n

            \u0393\u03b9\u03b1 \u03ba\u03ac\u03c0\u03bf\u03b9\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03c0\u03b1\u03c1\u03b1\u03c0\u03ac\u03bd\u03c9 \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03bb\u03b5\u03c0\u03c4\u03bf\u03bc\u03b5\u03c1\u03ae \u03ba\u03b1\u03b9 \u03b9\u03c3\u03c7\u03c5\u03c1\u03ac \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03c3\u03c5\u03bc\u03b2\u03bf\u03bb\u03ae \u03c4\u03bf\u03c5\u03c2 \u03c3\u03c4\u03b7\u03bd \u03c0\u03c1\u03bf\u03b4\u03b9\u03ac\u03b8\u03b5\u03c3\u03b7 \u03b3\u03b9\u03b1 \u0398\u0391, \u03b1\u03c0\u03cc \u03c0\u03bf\u03bb\u03bb\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03bd\u03ad\u03b1\u03c2 \u03bc\u03b5\u03b8\u03bf\u03b4\u03bf\u03bb\u03bf\u03b3\u03af\u03b1\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2, \u03b5\u03bd\u03ce \u03b3\u03b9\u03b1 \u03ac\u03bb\u03bb\u03b1 \u03b1\u03c0\u03b1\u03b9\u03c4\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03b9\u03bf \u03b1\u03ba\u03c1\u03b9\u03b2\u03b5\u03af\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2.<\/p>\n

            3.1.1. \u0393\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 \u03c4\u03c9\u03bd \u03bf\u03c0\u03bf\u03af\u03c9\u03bd \u03b7 \u03b5\u03bc\u03c0\u03bb\u03bf\u03ba\u03ae \u03c3\u03c4\u03b7\u03bd \u03c0\u03c1\u03bf\u03b4\u03b9\u03ac\u03b8\u03b5\u03c3\u03b7 \u03b3\u03b9\u03b1 \u0398\u0391 \u03ad\u03c7\u03b5\u03b9 \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03b9\u03c9\u03b8\u03b5\u03af \u03b1\u03c0\u03cc <\/b>GWAS<\/b> \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2<\/b><\/h6>\n

            \u0397<\/b>LA<\/b>–<\/b>DR<\/b> (6<\/b>p<\/b>21).<\/b> \u03a4\u03b1 \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 HLA-I \u03ba\u03b1\u03b9 \u0399\u0399 \u03ba\u03c9\u03b4\u03b9\u03ba\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd \u03b5\u03c4\u03b5\u03c1\u03bf\u03b4\u03b9\u03bc\u03b5\u03c1\u03b5\u03af\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2 (\u039c\u0397C-I \u03ba\u03b1\u03b9 MHC-II) \u03c5\u03c0\u03b5\u03cd\u03b8\u03c5\u03bd\u03b5\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03bd\u03c4\u03b9\u03b3\u03bf\u03bd\u03bf\u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1\u03c3\u03b7. To \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf \u0397LA-DR3 (\u0397LA-II) \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03ad\u03bd\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03c0\u03c1\u03ce\u03c4\u03b1 \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 \u03c0\u03bf\u03c5 \u03bc\u03b5\u03bb\u03b5\u03c4\u03ae\u03b8\u03b7\u03ba\u03b1\u03bd \u03ba\u03b1\u03b9 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03b5\u03b9 \u03b9\u03c3\u03c7\u03c5\u03c1\u03ae \u03c3\u03c5\u03c3\u03c7\u03ad\u03c4\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b7\u03bd GD (43). \u039f\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b1 \u03b1\u03bb\u03bb\u03ae\u03bb\u03b9\u03ac \u03c4\u03bf\u03c5, \u03b5\u03c0\u03b9\u03c4\u03c1\u03ad\u03c0\u03bf\u03c5\u03bd \u03c3\u03b5 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03b3\u03bf\u03bd\u03b9\u03ba\u03ac \u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03b1 \u03bd\u03b1 \u03c4\u03b1\u03b9\u03c1\u03b9\u03ac\u03b6\u03bf\u03c5\u03bd \u03ba\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b1 \u03c3\u03c4\u03b9\u03c2 \u03b8\u03ad\u03c3\u03b5\u03b9\u03c2 \u03c0\u03c1\u03cc\u03c3\u03b4\u03b5\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 MHC-II (peptide binding pockets) \u03ba\u03b1\u03b9 \u03ad\u03c4\u03c3\u03b9 \u03b7 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5\u03c2 \u03c3\u03c4\u03b1 CD4 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b9\u03bf \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae. \u03a0\u03c1\u03cc\u03c3\u03c6\u03b1\u03c4\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03ad\u03b4\u03b5\u03b9\u03be\u03b1\u03bd \u03c0\u03c9\u03c2 \u03b7 \u03cd\u03c0\u03b1\u03c1\u03be\u03b7 \u0391rg \u03c3\u03c4\u03b7 \u03b8\u03ad\u03c3\u03b7 74 \u03c4\u03b7\u03c2 \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03b1\u03c2 HLA-DRb1 (peptide binding pocket) \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03b5 \u03c0\u03c1\u03bf\u03b4\u03b9\u03ac\u03b8\u03b5\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7 GD (44), \u03b5\u03bd\u03ce \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03bf\u03b9\u03c7\u03bf \u03b1\u03bc\u03b9\u03bd\u03bf\u03be\u03cd \u03ad\u03c7\u03b5\u03b9 \u03b2\u03c1\u03b5\u03b8\u03b5\u03af \u03ba\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd HT (45). \u0395\u03ba\u03c4\u03cc\u03c2 \u03b1\u03c0\u03cc \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 \u03c3\u03b5 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ad\u03c2 \u03c4\u03bf\u03c5 \u0397LA-II (HLA-DRB1 \u03ba\u03b1\u03b9 HLA-DQA1), \u03c3\u03c4\u03b7\u03bd \u03b1\u03b9\u03c4\u03b9\u03bf\u03c0\u03b1\u03b8\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 \u0398\u0391 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b5\u03bc\u03c0\u03bb\u03b1\u03ba\u03b5\u03af \u03ba\u03b1\u03b9 \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 \u03c3\u03c4\u03b7\u03bd \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ae \u0397LA I (HLA-C, HLA-B) (44,46). \u038c\u03c0\u03c9\u03c2 \u03c0\u03c1\u03bf\u03b1\u03bd\u03b1\u03c6\u03ad\u03c1\u03b8\u03b7\u03ba\u03b5, \u03bf\u03b9 \u0397LA-I \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2 \u03b5\u03c0\u03b9\u03c6\u03b1\u03bd\u03b5\u03af\u03b1\u03c2 (\u039c\u0397C-I) \u03c0\u03c1\u03bf\u03c3\u03b4\u03ad\u03bd\u03bf\u03c5\u03bd \u03b2\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ac\/\u03b9\u03b9\u03ba\u03ac \u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03b9\u03ac\u03b6\u03bf\u03c5\u03bd \u03c3\u03c4\u03b1 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03c4\u03bf\u03be\u03b9\u03ba\u03ac CD8 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1.<\/p>\n

            CTLA<\/b>-4 (2<\/b>q<\/b>33).<\/b> <\/i>\u03a0\u03bf\u03bb\u03c5\u03bc\u03bf\u03c1\u03c6\u03b9\u03c3\u03bc\u03bf\u03af \u03c4\u03bf\u03c5 CTLA-4 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03bf\u03c5 o\u03b9 \u03bf\u03c0\u03bf\u03af\u03bf\u03b9 \u03bc\u03b5\u03b9\u03ce\u03bd\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03ae\/\u03ba\u03b1\u03b9 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03c4\u03bf\u03c5, \u03bf\u03b4\u03b7\u03b3\u03bf\u03cd\u03bd \u03c3\u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ce\u03bd \u03a4 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c3\u03c5\u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7 \u0397\u03a4 \u03ba\u03b1\u03b9 GD (47-53). \u0397 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03bf\u03c7\u03ae \u03c4\u03bf\u03c5 CTLA-4 \u03c3\u03c4\u03b7\u03bd \u03c0\u03c1\u03bf\u03b4\u03b9\u03ac\u03b8\u03b5\u03c3\u03b7 \u03b3\u03b9\u03b1 \u0398\u0391 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03cd\u03bd\u03b8\u03b5\u03c4\u03b7 \u03bc\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03cc\u03c3\u03bf \u03c4\u03bf \u03c0\u03c1\u03bf\u03c3\u03c4\u03b1\u03c4\u03b5\u03c5\u03c4\u03b9\u03ba\u03cc \u03b1\u03bb\u03bb\u03ae\u03bb\u03b9\u03bf \u0391 \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03c4\u03bf \u03c0\u03c1\u03bf\u03b4\u03b9\u03b1\u03b8\u03b5\u03c3\u03b9\u03ba\u03cc G \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03b5\u03c5\u03b8\u03cd\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9, \u03b1\u03bd \u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03bf\u03c5\u03bd \u03bc\u03b5 \u03ac\u03bb\u03bb\u03bf\u03c5\u03c2 \u03b5\u03c0\u03b9\u03c4\u03cc\u03c0\u03bf\u03c5\u03c2 (loci). \u0394\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03ba\u03cc\u03bc\u03b1 \u03b3\u03bd\u03c9\u03c3\u03c4\u03cc \u03c0\u03bf\u03b9\u03b1 \u03c0\u03b1\u03c1\u03b1\u03bb\u03bb\u03b1\u03b3\u03ae (variant) \u03ad\u03c7\u03b5\u03b9 \u03c4\u03b7 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03bf\u03c7\u03ae. \u0388\u03c9\u03c2 \u03c4\u03ce\u03c1\u03b1, \u03c4\u03ad\u03c3\u03c3\u03b5\u03c1\u03b5\u03b9\u03c2 \u03c0\u03bf\u03bb\u03c5\u03bc\u03bf\u03c1\u03c6\u03b9\u03c3\u03bc\u03bf\u03af \u03ad\u03c7\u03bf\u03c5\u03bd \u03bc\u03b5\u03bb\u03b5\u03c4\u03b7\u03b8\u03b5\u03af \u03bc\u03b5 \u03bb\u03b5\u03c0\u03c4\u03bf\u03bc\u03b5\u03c1\u03ae \u03c7\u03b1\u03c1\u03c4\u03bf\u03b3\u03c1\u03ac\u03c6\u03b7\u03c3\u03b7: \u0391\u03a4 \u03bc\u03b9\u03ba\u03c1\u03bf\u03b4\u03bf\u03c1\u03c5\u03c6\u03cc\u03c1\u03bf\u03c2 \u03c3\u03c4\u03b7\u03bd 3\u2019UTR \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ae, A\/G SNP \u03b8\u03ad\u03c3\u03b7\u03c2 49, A\/G SNP \u03ad\u03be\u03c9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd 3\u2019 UTR \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ae \u03ba\u03b1\u03b9 non-coding intron 1 \u03c0\u03b1\u03c1\u03b1\u03bb\u03bb\u03b1\u03b3\u03ae (47-53) \u03bc\u03b5 \u03c4\u03bf\u03bd \u03c0\u03c1\u03ce\u03c4\u03bf \u03ba\u03b1\u03b9 \u03c4\u03bf\u03bd \u03c4\u03c1\u03af\u03c4\u03bf \u03bd\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03bf\u03cd\u03bd \u03c4\u03bf\u03c5\u03c2 \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c4\u03b5\u03c1\u03bf\u03c5\u03c2 \u03c5\u03c0\u03bf\u03c8\u03ae\u03c6\u03b9\u03bf\u03c5\u03c2.<\/p>\n

            FCRL<\/b>3 (1<\/b>q<\/b>22).<\/b> \u0391\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03bc\u03ad\u03bb\u03bf\u03c2 \u03c4\u03b7\u03c2 \u03c5\u03c0\u03b5\u03c1\u03bf\u03b9\u03ba\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1\u03c2 \u03c4\u03c9\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03c9\u03bd \u03b1\u03bd\u03bf\u03c3\u03bf\u03c3\u03c6\u03b1\u03b9\u03c1\u03b9\u03bd\u03ce\u03bd. \u0397 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 \u03c0\u03bf\u03c5 \u03ba\u03c9\u03b4\u03b9\u03ba\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03c4\u03bf \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf FCRL3 \u03c0\u03b5\u03c1\u03b9\u03ad\u03c7\u03b5\u03b9 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03ac \u03ba\u03b1\u03b9 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03b1\u03bb\u03c4\u03b9\u03ba\u03ac \u03bc\u03bf\u03c4\u03af\u03b2\u03b1 \u03c3\u03c4\u03b7\u03bd \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03c0\u03bb\u03b1\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c4\u03b7\u03c2 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ae (immunoreceptor-tyrosine activation and inhibitory motifs) \u03ba\u03b1\u03b9 \u03b5\u03bb\u03ad\u03b3\u03c7\u03b5\u03b9 \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03c4\u03c1\u03bf\u03c5\u03c2 \u03c4\u03b7\u03c2 \u03bc\u03b5\u03c4\u03ac\u03b4\u03bf\u03c3\u03b7\u03c2 \u03c3\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c4\u03c9\u03bd \u0392 \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd. \u03a0\u03bf\u03bb\u03c5\u03bc\u03bf\u03c1\u03c6\u03b9\u03c3\u03bc\u03bf\u03af \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03bf\u03c5 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b5\u03bd\u03bf\u03c7\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03b5\u03af \u03b3\u03b9\u03b1 \u03c0\u03c1\u03bf\u03b4\u03b9\u03ac\u03b8\u03b5\u03c3\u03b7 \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7\u03c2 \u0398\u0391 (42,54).<\/p>\n

            CD<\/b>40 (20<\/b>q<\/b>13).<\/b> \u03a4\u03bf CD40 \u03b5\u03ba\u03c6\u03c1\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c3\u03c4\u03b1 \u0392 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03ba\u03b1\u03b9 APC \u03ba\u03b1\u03b9 \u03c0\u03b1\u03af\u03b6\u03b5\u03b9 \u03b2\u03b1\u03c3\u03b9\u03ba\u03cc \u03c1\u03cc\u03bb\u03bf \u03c3\u03c4\u03b7\u03bd \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03ae \u03c4\u03bf\u03c5\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03ad\u03ba\u03ba\u03c1\u03b9\u03c3\u03b7 \u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd. \u03a4\u03b1 \u03b8\u03c5\u03c1\u03b5\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03bd\u03b1 \u03c4\u03bf \u03b5\u03ba\u03c6\u03c1\u03ac\u03c3\u03bf\u03c5\u03bd \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03c6\u03ac\u03bd\u03b5\u03b9\u03ac \u03c4\u03bf\u03c5\u03c2 (55). \u0388\u03c7\u03b5\u03b9 \u03b2\u03c1\u03b5\u03b8\u03b5\u03af \u03c0\u03c9\u03c2 \u03b7 \u03c3\u03cd\u03bd\u03b4\u03b5\u03c3\u03b7 CD40\/CD40L \u03b5\u03c0\u03ac\u03b3\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd CD8 Tregs. \u039c\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c3\u03cd\u03bd\u03b4\u03b5\u03c3\u03b7\u03c2 \u03c3\u03b5 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03bf \u03b3\u03bf\u03bd\u03b9\u03b4\u03b9\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 \u03bc\u03b5 \u03bb\u03b5\u03c0\u03c4\u03bf\u03bc\u03b5\u03c1\u03ae \u03c7\u03b1\u03c1\u03c4\u03bf\u03b3\u03c1\u03ac\u03c6\u03b7\u03c3\u03b7 (whole-genome linkage studies) \u03b1\u03bd\u03ad\u03b4\u03b5\u03b9\u03be\u03b1\u03bd \u03ad\u03bd\u03b1\u03bd \u03b5\u03c0\u03af\u03c4\u03bf\u03c0\u03bf \u03c4\u03bf\u03c5 CD40 \u03c3\u03c4\u03bf \u03c7\u03c1\u03c9\u03bc\u03cc\u03c3\u03c9\u03bc\u03b1 20q \u03bf \u03bf\u03c0\u03bf\u03af\u03bf\u03c2 \u03c3\u03c5\u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c0\u03c1\u03bf\u03b4\u03b9\u03ac\u03b8\u03b5\u03c3\u03b7 \u03b3\u03b9\u03b1 GD (56-58) . \u039f \u03b5\u03c0\u03af\u03c4\u03bf\u03c0\u03bf\u03c2 \u03b1\u03c5\u03c4\u03cc\u03c2 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03ad\u03bd\u03b1\u03bd C\/T SNP \u03c0\u03bf\u03bb\u03c5\u03bc\u03bf\u03c1\u03c6\u03b9\u03c3\u03bc\u03cc \u03c3\u03c4\u03b7\u03bd \u03b1\u03bb\u03bb\u03b7\u03bb\u03bf\u03c5\u03c7\u03af\u03b1 Kozak \u03c0\u03bf\u03c5 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 CD40 \u03c3\u03c4\u03b1 \u0392, \u03c4\u03b1 \u0391PC \u03ae\/\u03ba\u03b1\u03b9 \u03c4\u03b1 \u03b8\u03c5\u03c1\u03b5\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 (59) \u03ba\u03b1\u03b9 \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03b5 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae anti-TSHR \u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd.<\/p>\n

            PTPN22 (protein tyrosine phosphatase 22)<\/i><\/b> (1q13). <\/b>\u03a4\u03bf \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf \u03b1\u03c5\u03c4\u03cc \u03ba\u03c9\u03b4\u03b9\u03ba\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03c4\u03b7 \u03bb\u03b5\u03bc\u03c6\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae \u03c4\u03c5\u03c1\u03bf\u03c3\u03b9\u03bd\u03b9\u03ba\u03ae \u03c6\u03c9\u03c3\u03c6\u03b1\u03c4\u03ac\u03c3\u03b7 (lymphoid tyrosine phosphatase) \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03b1\u03bb\u03c4\u03b9\u03ba\u03cc\u03c2 \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03c4\u03ae\u03c2 \u03c4\u03b7\u03c2 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd \u03a4 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd (60). \u039f \u03b5\u03bc\u03c0\u03bb\u03b5\u03ba\u03cc\u03bc\u03b5\u03bd\u03bf\u03c2 SNP \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03c4\u03b7\u03bd \u03b1\u03bd\u03c4\u03b9\u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03c1\u03b3\u03b9\u03bd\u03af\u03bd\u03b7\u03c2 \u03bc\u03b5 \u03c4\u03c1\u03c5\u03c0\u03c4\u03bf\u03c6\u03ac\u03bd\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03b7 \u03b4\u03b7\u03bc\u03b9\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03bc\u03b9\u03b1\u03c2 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03ae\u03c2 (gain of function) \u03c0\u03b1\u03c1\u03b1\u03bb\u03bb\u03b1\u03b3\u03ae\u03c2 \u03c3\u03c4\u03b7\u03bd \u03b8\u03ad\u03c3\u03b7 620 (R620W) (61,62). \u03a3\u03c5\u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c4\u03cc\u03c3\u03bf \u03bc\u03b5 \u03c4\u03b7\u03bd \u03c0\u03c1\u03bf\u03b4\u03b9\u03ac\u03b8\u03b5\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 GD \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03bc\u03b5 \u0397\u03a4 \u03bb\u03cc\u03b3\u03c9 \u03c4\u03b7\u03c2 \u03b5\u03c0\u03b1\u03ba\u03cc\u03bb\u03bf\u03c5\u03b8\u03b7\u03c2 \u03bc\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7\u03c2 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd \u03a4 \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c0\u03bf\u03c5 \u03af\u03c3\u03c9\u03c2 \u03b5\u03c0\u03b9\u03c4\u03c1\u03ad\u03c0\u03b5\u03b9 \u03c3\u03b5 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03a4 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 (T effectors) \u03bd\u03b1 \u03b4\u03b9\u03b1\u03c6\u03cd\u03b3\u03bf\u03c5\u03bd \u03c4\u03c9\u03bd \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03ce\u03bd \u03c4\u03b7\u03c2 \u03b8\u03c5\u03bc\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03bf\u03c7\u03ae\u03c2.<\/b><\/p>\n

            \u0399<\/b>L<\/b>2<\/b>Ra<\/b>\/ <\/b>CD<\/b>25 (10<\/b>q<\/b>15).<\/b> \u0397 \u03cd\u03c0\u03b1\u03c1\u03be\u03b7 \u03c0\u03bf\u03bb\u03c5\u03bc\u03bf\u03c1\u03c6\u03b9\u03c3\u03bc\u03ce\u03bd \u03c4\u03bf\u03c5 CD25 \u03ad\u03c7\u03b5\u03b9 \u03c3\u03c5\u03c3\u03c7\u03b5\u03c4\u03b9\u03c3\u03c4\u03b5\u03af \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7 \u03c0\u03c1\u03bf\u03b4\u03b9\u03ac\u03b8\u03b5\u03c3\u03b7\u03c2 \u03b3\u03b9\u03b1 GD (63). \u039f\u03b9 \u03c0\u03bf\u03bb\u03c5\u03bc\u03bf\u03c1\u03c6\u03b9\u03c3\u03bc\u03bf\u03af \u03b1\u03c5\u03c4\u03bf\u03af \u03bc\u03ac\u03bb\u03bb\u03bf\u03bd \u03b5\u03bc\u03c0\u03bb\u03ad\u03ba\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03b1\u03bb\u03c4\u03b9\u03ba\u03ae \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03c4\u03c9\u03bd \u03a4regs \u03ba\u03b1\u03b9 \u03cc\u03c7\u03b9 \u03c4\u03cc\u03c3\u03bf \u03c3\u03c4\u03b7 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ae \u03c4\u03bf\u03c5 \u03b1\u03c1\u03b9\u03b8\u03bc\u03bf\u03cd \u03c4\u03bf\u03c5\u03c2, \u03bc\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03ac \u03c4\u03c9\u03bd Tregs \u03b4\u03b5\u03bd \u03ad\u03c7\u03b5\u03b9 \u03b1\u03c0\u03bf\u03b4\u03b5\u03b9\u03c7\u03c4\u03b5\u03af \u03bc\u03b5 \u03b2\u03b5\u03b2\u03b1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c0\u03c9\u03c2 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7 \u0398\u0391 (64).<\/p>\n

            TSHR<\/b> (14<\/b>q<\/b>13).<\/b> \u039f\u03b9 \u03bc\u03b5\u03bb\u03b5\u03c4\u03ce\u03bc\u03b5\u03bd\u03bf\u03b9 \u03c0\u03bf\u03bb\u03c5\u03bc\u03bf\u03c1\u03c6\u03b9\u03c3\u03bc\u03bf\u03af \u03b1\u03c6\u03bf\u03c1\u03bf\u03cd\u03bd \u03c3\u03b5 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ad\u03c2 \u03b9\u03bd\u03c4\u03c1\u03bf\u03bd\u03af\u03c9\u03bd \u03c0\u03bf\u03c5 \u03b4\u03b5\u03bd \u03ba\u03c9\u03b4\u03b9\u03ba\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2 (non-coding intronic SNPs) (65,66,67). \u039f \u03c0\u03b9\u03bf \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc\u03c2 \u03b1\u03c0\u03cc \u03b1\u03c5\u03c4\u03bf\u03cd\u03c2 ( intron 1 SNP) \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bc\u03b5\u03c4\u03b1\u03b2\u03ac\u03bb\u03bb\u03b5\u03b9 \u03c4\u03bf \u03b5\u03bd\u03b1\u03bb\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03cc \u03bc\u03ac\u03c4\u03b9\u03c3\u03bc\u03b1 (splicing) \u03c4\u03bf\u03c5 TSHR (68). \u0397 \u03b5\u03bc\u03c0\u03bb\u03bf\u03ba\u03ae \u03cc\u03bb\u03c9\u03bd \u03c4\u03c9\u03bd \u03c0\u03b1\u03c1\u03b1\u03bb\u03bb\u03b1\u03b3\u03ce\u03bd (variants) \u03c0\u03bf\u03c5 \u03b5\u03bd\u03c4\u03bf\u03c0\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03ad\u03c3\u03b1 \u03ba\u03b1\u03b9 \u03b1\u03bc\u03ad\u03c3\u03c9\u03c2 \u03ad\u03be\u03c9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd 40 \u039ap \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ae \u03c4\u03bf\u03c5 \u03b9\u03bd\u03c4\u03c1\u03bf\u03bd\u03af\u03bf\u03c5 1 \u03ba\u03b1\u03b8\u03ce\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03bf\u03c5 \u03b9\u03bd\u03c4\u03c1\u03bf\u03bd\u03af\u03bf\u03c5 7 \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af \u03c0\u03b5\u03c1\u03b1\u03b9\u03c4\u03ad\u03c1\u03c9 \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1.<\/p>\n

            SCGB3A2\/ secretoglobin family 3A member 2 (5q32).<\/b> <\/i>\u0391\u03c1\u03c7\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c3\u03cd\u03bd\u03b4\u03b5\u03c3\u03b7\u03c2 (linkage studies) \u03b5\u03bd\u03c4\u03cc\u03c0\u03b9\u03c3\u03b1\u03bd \u03c4\u03b7\u03bd \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ae 5q31-33 \u03c3\u03c4\u03b7\u03bd \u03bf\u03c0\u03bf\u03af\u03b1 \u03c0\u03b5\u03c1\u03b9\u03ad\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c0\u03bf\u03bb\u03bb\u03ac \u03c5\u03c0\u03bf\u03c8\u03ae\u03c6\u03b9\u03b1 \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 (\u03c0.\u03c7 IL13, IL4) \u03c0\u03c1\u03bf\u03b4\u03b9\u03ac\u03b8\u03b5\u03c3\u03b7\u03c2 \u03b3\u03b9\u03b1 \u0398\u0391 (69). \u039c\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c3\u03c5\u03c3\u03c7\u03ad\u03c4\u03b9\u03c3\u03b7\u03c2 (association studies) \u03b1\u03bd\u03ad\u03b4\u03b5\u03b9\u03be\u03b1\u03bd \u03c4\u03bf SCG\u03923\u03912 \u03c9\u03c2 \u03c3\u03c7\u03b5\u03c4\u03b9\u03b6\u03cc\u03bc\u03b5\u03bd\u03bf \u03bc\u03b5 \u03c0\u03c1\u03bf\u03b4\u03b9\u03ac\u03b8\u03b5\u03c3\u03b7 \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7\u03c2 \u0398\u0391 (70). \u039f \u03c0\u03b9\u03bf \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc\u03c2 SNP \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf rs1368408 \u03c0\u03bf\u03c5 \u03c3\u03c5\u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7 GD (71). \u03a9\u03c3\u03c4\u03cc\u03c3\u03bf \u03bc\u03b9\u03b1 \u03c0\u03c1\u03cc\u03c3\u03c6\u03b1\u03c4\u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03c3\u03c5\u03c3\u03c7\u03ad\u03c4\u03b9\u03c3\u03b7\u03c2 \u03ad\u03b4\u03b5\u03b9\u03be\u03b5 \u03c0\u03c9\u03c2 \u03b4\u03b5\u03bd \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03b9\u03c3\u03c4\u03b5\u03af \u03c4\u03bf \u03b3\u03b5\u03b3\u03bf\u03bd\u03cc\u03c2 \u03ba\u03b1\u03b9 \u03ac\u03bb\u03bb\u03b1 \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 \u03c3\u03c4\u03b7\u03bd \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ae \u03b1\u03c5\u03c4\u03ae (\u03c0.\u03c7 IL-3) \u03bd\u03b1 \u03b5\u03bc\u03c0\u03bb\u03ad\u03ba\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03c0\u03b1\u03b8\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 \u0398\u0391 (72) .<\/i><\/p>\n

            Tg<\/b> (8<\/b>q<\/b>24).<\/b> <\/i>\u039c\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c3\u03cd\u03bd\u03b4\u03b5\u03c3\u03b7\u03c2 \u03c3\u03b5 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03bf \u03b3\u03bf\u03bd\u03b9\u03b4\u03b9\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 (whole genome linkage studies) \u03b1\u03c0\u03b5\u03ba\u03ac\u03bb\u03c5\u03c8\u03b1\u03bd \u03c4\u03b7 \u03c3\u03c5\u03c3\u03c7\u03ad\u03c4\u03b9\u03c3\u03b7 \u03c0\u03bf\u03bb\u03c5\u03bc\u03bf\u03c1\u03c6\u03b9\u03c3\u03bc\u03ce\u03bd \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03bf\u03c5 \u03c4\u03b7\u03c2 \u03b8\u03c5\u03c1\u03b5\u03bf\u03c3\u03c6\u03b1\u03b9\u03c1\u03af\u03bd\u03b7\u03c2 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7 GD (73,74). H \u03b1\u03bb\u03bb\u03b7\u03bb\u03bf\u03cd\u03c7\u03b9\u03c3\u03b7 \u03c0\u03bf\u03c5 \u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b5, \u03b1\u03c0\u03b5\u03ba\u03ac\u03bb\u03c5\u03c8\u03b5 \u03c4\u03c1\u03b5\u03b9\u03c2 \u03c0\u03b1\u03c1\u03b1\u03bb\u03bb\u03b1\u03b3\u03ad\u03c2 (A734S, V1027M, W1999R) \u03c0\u03bf\u03c5 \u03af\u03c3\u03c9\u03c2 \u03bc\u03b5\u03c4\u03b1\u03b2\u03ac\u03bb\u03bb\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03b1\u03c0\u03bf\u03b4\u03cc\u03bc\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 Tg \u03c3\u03c4\u03b1 \u03b5\u03bd\u03b4\u03bf\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1, \u03bf\u03b4\u03b7\u03b3\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c3\u03b5 \u03c0\u03b1\u03b8\u03bf\u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ac Tg \u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03b1 \u03bc\u03b5 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03b1\u03bd\u03c4\u03b9\u03b3\u03bf\u03bd\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 (75). \u03a4\u03b1 \u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03b1 \u03b1\u03c5\u03c4\u03ac \u03af\u03c3\u03c9\u03c2 \u03b5\u03c5\u03bd\u03bf\u03bf\u03cd\u03bd \u03c4\u03b7\u03bd \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ce\u03bd \u03a4 \u03ba\u03b1\u03b9 \u0392 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd.<\/p>\n

            3.1.2. \u039d\u03ad\u03b1 \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 \u03b1\u03c0\u03cc <\/b>GWAS<\/b> \u03bc\u03b5 \u03b9\u03c3\u03c7\u03c5\u03c1\u03ac \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1 \u03c3\u03c5\u03c3\u03c7\u03ad\u03c4\u03b9\u03c3\u03b7\u03c2 \u03b3\u03b9\u03b1 \u03c0\u03c1\u03bf\u03b4\u03b9\u03ac\u03b8\u03b5\u03c3\u03b7 \u0398\u0391<\/b><\/h6>\n

            \u00a0<\/b>\u0395\u03c0\u03c4\u03ac \u03bd\u03ad\u03bf\u03b9 \u03b5\u03c0\u03af\u03c4\u03bf\u03c0\u03bf\u03b9 (loci) \u03b1\u03bd\u03b1\u03ba\u03b1\u03bb\u03cd\u03c6\u03b8\u03b7\u03ba\u03b1\u03bd \u03c0\u03c1\u03cc\u03c3\u03c6\u03b1\u03c4\u03b1 \u03c3\u03c4\u03b7 \u039c. \u0392\u03c1\u03b5\u03c4\u03b1\u03bd\u03af\u03b1 \u03bc\u03b5 \u03c4\u03b7 \u03c7\u03c1\u03ae\u03c3\u03b7 \u03c4\u03bf\u03c5 WTCCC ImmunoChip (40-42): \u039c\u039c\u0395L1, LPP, BACH2 (\u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b1\u03c0\u03ac\u03bd\u03c4\u03b7\u03c3\u03b7 \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03b9\u03ce\u03bd), FGFR1oP, PRICKLE1, 216 kb upstream of TRIB2, 83 kb upstream of ITGAM, CCR6 (lymphocyte trafficking) (76,77). \u03a0\u03c1\u03cc\u03c3\u03c6\u03b1\u03c4\u03b1 \u03bc\u03b9\u03b1 \u03bf\u03bc\u03ac\u03b4\u03b1 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03ce\u03bd \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u039a\u03af\u03bd\u03b1 \u03c0\u03b5\u03c1\u03b9\u03ad\u03b3\u03c1\u03b1\u03c8\u03b5 \u03b1\u03ba\u03cc\u03bc\u03b1 5 \u03bd\u03ad\u03bf\u03c5\u03c2 \u03b5\u03c0\u03b9\u03c4\u03cc\u03c0\u03bf\u03c5\u03c2 \u03c0\u03bf\u03c5 \u03c3\u03c5\u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7 GD (\u03a7q21.1, 22q12.3-13.1, 1q23.2, 9q34.2 14q32.2) (78). \u0395\u03c0\u03af\u03c3\u03b7\u03c2 \u03bb\u03b5\u03c0\u03c4\u03bf\u03bc\u03b5\u03c1\u03ae\u03c2 \u03c7\u03b1\u03c1\u03c4\u03bf\u03b3\u03c1\u03ac\u03c6\u03b7\u03c3\u03b7 \u03c3\u03c4\u03b1 \u03c7\u03c1\u03c9\u03bc\u03bf\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 10q \u03ba\u03b1\u03b9 14q \u03b1\u03c0\u03b5\u03ba\u03ac\u03bb\u03c5\u03c8\u03b5 \u03bd\u03ad\u03bf\u03c5\u03c2 \u03b5\u03c0\u03b9\u03c4\u03cc\u03c0\u03bf\u03c5\u03c2 \u03c0\u03c1\u03bf\u03b4\u03b9\u03ac\u03b8\u03b5\u03c3\u03b7\u03c2 \u03b3\u03b9\u03b1 \u0398\u0391 (10q \/SNP rs6479778 \u03c3\u03c4\u03b7\u03bd \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ae \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03bf\u03c5 \u0391RID5B \u03c4\u03bf \u03bf\u03c0\u03bf\u03af\u03bf \u03c3\u03c5\u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03bc\u03b5 \u03c1\u03b5\u03c5\u03bc\u03b1\u03c4\u03bf\u03b5\u03b9\u03b4\u03ae \u03b1\u03c1\u03b8\u03c1\u03af\u03c4\u03b9\u03b4\u03b1) \u03ba\u03b1\u03b9 \u03b3\u03b9\u03b1 GD (14q\/ SNP rs12147587, rs2284720 \u03c3\u03c4\u03b7\u03bd \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ae \u03c4\u03c9\u03bd \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03c9\u03bd \u039d\u03a1\u03a7\u039d3 \u03ba\u03b1\u03b9 TSHR \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03bf\u03b9\u03c7\u03b1) (79).<\/p>\n

            3.1.3. \u0393\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 \u03c4\u03c9\u03bd \u03bf\u03c0\u03bf\u03af\u03c9\u03bd \u03b7 \u03b5\u03bc\u03c0\u03bb\u03bf\u03ba\u03ae \u03c3\u03c4\u03b7\u03bd \u03c0\u03c1\u03bf\u03b4\u03b9\u03ac\u03b8\u03b5\u03c3\u03b7 \u03b3\u03b9\u03b1 \u0398\u0391 \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03af\u03c9\u03c3\u03b7 \u03b1\u03c0\u03cc \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03bd\u03ad\u03b1\u03c2 \u03bc\u03b5\u03b8\u03bf\u03b4\u03bf\u03bb\u03bf\u03b3\u03af\u03b1\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2<\/b><\/h6>\n

            HLA-B*46, TPO, IL23R, TNF-a, IL-13, IL-3, IL-4, IL-6 (80), IL-17F (81), IL-1RN, VDR (82), ZFAT (83), LTA, FOXP3, TCR-b, PSMB8-9, DIO2, ADRB2, FCGRIIa, FIH, PDCD1, NLRP1(84), VEGF (85), DNMT1 GD (86), MTRR HT (86), TBX21 (87), HLX (87), \u0391\u0399RE.<\/p>\n

            \u03a4\u03b1 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b1 \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 \u03c0\u03bf\u03c5 \u03c3\u03c5\u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7 \u03c0\u03c1\u03bf\u03b4\u03b9\u03ac\u03b8\u03b5\u03c3\u03b7\u03c2 \u03b3\u03b9\u03b1 \u0398\u0391 \u03b1\u03c6\u03bf\u03c1\u03bf\u03cd\u03bd \u03c3\u03c4\u03b7 GD. \u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b5\u03be\u03b1\u03af\u03c1\u03b5\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c0\u03b1\u03c1\u03b1\u03bb\u03bb\u03b1\u03b3\u03ae\u03c2 \u0397LA-DRb1 Arg 74 \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03ad\u03c7\u03b5\u03b9 \u039fR (odds ratio) >5 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7 GD, \u03c4\u03b1 \u03c5\u03c0\u03cc\u03bb\u03bf\u03b9\u03c0\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03bc\u03b9\u03ba\u03c1\u03ae \u03c3\u03c5\u03bc\u03b2\u03bf\u03bb\u03ae \u03bc\u03b5 OR < 1,5-2. \u03a6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bb\u03bf\u03b9\u03c0\u03cc\u03bd \u03c0\u03c9\u03c2 \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03b1\u03bd\u03b1\u03c0\u03c4\u03cd\u03be\u03b5\u03b9 \u03ad\u03bd\u03b1 \u03ac\u03c4\u03bf\u03bc\u03bf \u03c4\u03b7 \u03bd\u03cc\u03c3\u03bf \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03ba\u03bb\u03b7\u03c1\u03bf\u03bd\u03bf\u03bc\u03ae\u03c3\u03b5\u03b9 \u03c0\u03bf\u03bb\u03bb\u03ac \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ac \u03c0\u03c1\u03bf\u03b4\u03b9\u03b1\u03b8\u03b5\u03c3\u03b9\u03ba\u03ac \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1. \u0397 \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03cc\u03bc\u03c9\u03c2 \u03c3\u03c5\u03bd\u03cd\u03c0\u03b1\u03c1\u03be\u03b7\u03c2 \u03c3\u03b5 \u03ad\u03bd\u03b1 \u03ac\u03c4\u03bf\u03bc\u03bf \u03c0\u03bf\u03bb\u03bb\u03ce\u03bd \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03c9\u03bd \u03bc\u03b5 \u03bc\u03b9\u03ba\u03c1\u03cc OR, \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03c4\u03b7 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5 \u03c3\u03c4\u03bf \u03b3\u03b5\u03bd\u03b9\u03ba\u03cc \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03cc \u03bc\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ac \u03b5\u03c6\u03b9\u03ba\u03c4\u03cc \u03b7 \u0398\u0391 \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03c4\u03cc\u03c3\u03bf \u03c3\u03c5\u03c7\u03bd\u03ae \u03bd\u03cc\u03c3\u03bf\u03c2 \u03bc\u03b5 \u03c4\u03b1\u03c5\u03c4\u03cc\u03c7\u03c1\u03bf\u03bd\u03b7 \u03c3\u03c5\u03bd\u03cd\u03c0\u03b1\u03c1\u03be\u03b7 \u03c0\u03bf\u03bb\u03bb\u03ce\u03bd \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ce\u03bd \u03c0\u03c1\u03bf\u03b4\u03b9\u03b1\u03b8\u03b5\u03c3\u03b9\u03ba\u03ce\u03bd \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03c9\u03bd \u03c3\u03b5 \u03ba\u03ac\u03b8\u03b5 \u03ad\u03bd\u03b1 \u03ac\u03c4\u03bf\u03bc\u03bf \u03be\u03b5\u03c7\u03c9\u03c1\u03b9\u03c3\u03c4\u03ac. \u0397 \u03c5\u03c0\u03cc\u03b8\u03b5\u03c3\u03b7 \u03c0\u03bf\u03c5 \u03ad\u03c7\u03b5\u03b9 \u03b4\u03b9\u03b1\u03c4\u03c5\u03c0\u03c9\u03b8\u03b5\u03af \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03bf\u03bc\u03ac\u03b4\u03b1 \u03c4\u03bf\u03c5 Tomer \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03c9\u03c2 \u03b5\u03af\u03c4\u03b5 \u03c4\u03b1 \u03c0\u03c1\u03bf\u03b4\u03b9\u03b1\u03b8\u03b5\u03c3\u03b9\u03ba\u03ac \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 \u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03b9\u03b4\u03c1\u03bf\u03cd\u03bd \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03c4\u03bf\u03c5\u03c2 \u03b1\u03c5\u03be\u03ac\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03bf \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03cc OR \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u0398\u0391, \u03b5\u03af\u03c4\u03b5 \u03c0\u03c9\u03c2 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b1 \u03c0\u03c1\u03bf\u03b4\u03b9\u03b1\u03b8\u03b5\u03c3\u03b9\u03ba\u03ac \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf OR \u03b1\u03bb\u03bb\u03ac \u03bc\u03cc\u03bd\u03bf \u03c3\u03b5 \u03ba\u03ac\u03c0\u03bf\u03b9\u03b1 \u03c5\u03c0\u03bf\u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b1 \u03c4\u03b7\u03c2 \u0397\u03a4 \u03ae GD \u03b5\u03bd\u03ce \u03c3\u03c4\u03bf \u03c3\u03cd\u03bd\u03bf\u03bb\u03bf \u03c4\u03c9\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03ad\u03c7\u03bf\u03c5\u03bd \u03b1\u03b9\u03c3\u03b8\u03b7\u03c4\u03ac \u03bc\u03b9\u03ba\u03c1\u03cc\u03c4\u03b5\u03c1\u03bf OR. \u03a0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03c9\u03c3\u03c4\u03cc\u03c3\u03bf \u03bd\u03b1 \u03c4\u03bf\u03bd\u03b9\u03c3\u03c4\u03b5\u03af \u03c0\u03c9\u03c2 \u03bf\u03b9 \u03b3\u03bf\u03bd\u03b9\u03b4\u03b9\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03b4\u03b5\u03af\u03c7\u03bd\u03bf\u03c5\u03bd \u03cc\u03c4\u03b9 \u03c4\u03b1 \u03c0\u03b9\u03bf \u03b9\u03c3\u03c7\u03c5\u03c1\u03ac \u03b1\u03c0\u03bf\u03b4\u03b5\u03b9\u03ba\u03c4\u03b9\u03ba\u03ac \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1 \u03b3\u03b9\u03b1 \u03c0\u03c1\u03bf\u03b4\u03b9\u03b1\u03b8\u03b5\u03c3\u03b9\u03ba\u03bf\u03cd\u03c2 \u03c0\u03bf\u03bb\u03c5\u03bc\u03bf\u03c1\u03c6\u03b9\u03c3\u03bc\u03bf\u03cd\u03c2 \u03b1\u03c6\u03bf\u03c1\u03bf\u03cd\u03bd \u03c3\u03c4\u03bf HLA(DR3) \u03ba\u03b1\u03b9 \u03c3\u03c4\u03bf CTLA-4 \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf.<\/p>\n

            3.2. \u03a0\u03b5\u03c1\u03b9\u03b2\u03b1\u03bb\u03bb\u03bf\u03bd\u03c4\u03b9\u03ba\u03bf\u03af \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2<\/b><\/h5>\n

            \u038c\u03c0\u03c9\u03c2 \u03c0\u03c1\u03bf\u03b1\u03bd\u03b1\u03c6\u03ad\u03c1\u03b8\u03b7\u03ba\u03b5, \u03b7 \u03cd\u03c0\u03b1\u03c1\u03be\u03b7 \u03bc\u03cc\u03bd\u03bf \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ce\u03bd \u03c0\u03c1\u03bf\u03b4\u03b9\u03b1\u03b8\u03b5\u03c3\u03b9\u03ba\u03ce\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03cc\u03bd\u03c4\u03c9\u03bd \u03b4\u03b5\u03bd \u03b1\u03c1\u03ba\u03b5\u03af \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03b1\u03b9\u03c4\u03b9\u03bf\u03bb\u03bf\u03b3\u03ae\u03c3\u03b5\u03b9 \u03c0\u03bb\u03ae\u03c1\u03c9\u03c2 \u03c4\u03b7\u03bd \u03b1\u03b9\u03c4\u03b9\u03bf\u03c0\u03b1\u03b8\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 \u0398\u0391. \u03a4\u03bf\u03c5\u03bb\u03ac\u03c7\u03b9\u03c3\u03c4\u03bf\u03bd 20% \u03c4\u03bf\u03c5 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7\u03c2 \u0398\u0391 \u03bf\u03c6\u03b5\u03af\u03bb\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03c0\u03b5\u03c1\u03b9\u03b2\u03b1\u03bb\u03bb\u03bf\u03bd\u03c4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2. \u039c\u03b5\u03c4\u03b1\u03be\u03cd \u03c4\u03c9\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03cc\u03bd\u03c4\u03c9\u03bd \u03c0\u03bf\u03c5 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b5\u03bd\u03bf\u03c7\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03b5\u03af \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 \u0398\u0391 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf \u03ba\u03ac\u03c0\u03bd\u03b9\u03c3\u03bc\u03b1 (88), \u03bf\u03b9 \u03c3\u03c4\u03b5\u03c1\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ad\u03c2 \u03bf\u03c1\u03bc\u03cc\u03bd\u03b5\u03c2, \u03c4\u03bf \u03c4\u03c1\u03b1\u03cd\u03bc\u03b1, \u03c4\u03bf \u03b9\u03ce\u03b4\u03b9\u03bf (89), \u03c4\u03bf stress (90), \u03b7 \u03ad\u03bb\u03bb\u03b5\u03b9\u03c8\u03b7 \u03c3\u03b5\u03bb\u03b7\u03bd\u03af\u03bf\u03c5, \u03b4\u03b9\u03ac\u03c6\u03bf\u03c1\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 (\u03c0.\u03c7. \u03b1\u03bc\u03b9\u03c9\u03b4\u03b1\u03c1\u03cc\u03bd\u03b7, \u03b9\u03bd\u03c4\u03b5\u03c1\u03c6\u03b5\u03c1\u03cc\u03bd\u03b7-\u03b1, antiCD52) \u03ba\u03b1\u03b9 \u03bc\u03b9\u03ba\u03c1\u03bf\u03b2\u03b9\u03b1\u03ba\u03bf\u03af \u03bf\u03c1\u03b3\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03af (\u03c0.\u03c7. Yersinia Enterocolitica) (91,92). \u0393\u03b9\u03b1 \u03c4\u03bf\u03c5\u03c2 \u03c4\u03b5\u03bb\u03b5\u03c5\u03c4\u03b1\u03af\u03bf\u03c5\u03c2 \u03b8\u03b5\u03c9\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03c0\u03c9\u03c2 \u03c4\u03b1 \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03ba\u03ac\u03c0\u03bf\u03b9\u03c9\u03bd \u03b1\u03c0\u03cc \u03b1\u03c5\u03c4\u03bf\u03cd\u03c2 \u03af\u03c3\u03c9\u03c2 \u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03b9\u03b4\u03c1\u03bf\u03cd\u03bd \u03ba\u03b1\u03b9 \u03bc\u03b5 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2 \u03c4\u03bf\u03c5 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03bf\u03c5 \u03bb\u03cc\u03b3\u03c9 \u03b4\u03bf\u03bc\u03b9\u03ba\u03ae\u03c2 \u03bf\u03bc\u03bf\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 (\u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03ae \u03bc\u03af\u03bc\u03b7\u03c3\u03b7). \u039c\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ad\u03c2 \u03c3\u03c4\u03b7\u03bd \u03b5\u03bd\u03c4\u03b5\u03c1\u03b9\u03ba\u03ae \u03c7\u03bb\u03c9\u03c1\u03af\u03b4\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03b5\u03bd\u03bf\u03c7\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03b5\u03af \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03c0\u03c1\u03cc\u03ba\u03bb\u03b7\u03c3\u03b7 \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ce\u03bd \u03b1\u03bd\u03c4\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03bf\u03c3\u03af\u03b1\u03c2, \u03cc\u03c0\u03c9\u03c2 \u03c3\u03c4\u03b7\u03bd \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ce\u03b4\u03bf\u03c5\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5 \u03c4\u03bf\u03c5 \u03b5\u03bd\u03c4\u03ad\u03c1\u03bf\u03c5, \u03c4\u03b7\u03c2 \u03c3\u03ba\u03bb\u03ae\u03c1\u03c5\u03bd\u03c3\u03b7\u03c2 \u03ba\u03b1\u03c4\u03ac \u03c0\u03bb\u03ac\u03ba\u03b1\u03c2, \u03c4\u03bf\u03c5 \u03c3\u03b1\u03ba\u03c7\u03b1\u03c1\u03ce\u03b4\u03bf\u03c5\u03c2 \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7 \u03c4\u03cd\u03c0\u03bf\u03c5 1 (\u03a3\u03941) \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03c1\u03b5\u03c5\u03bc\u03b1\u03c4\u03bf\u03b5\u03b9\u03b4\u03bf\u03cd\u03c2 \u03b1\u03c1\u03b8\u03c1\u03af\u03c4\u03b9\u03b4\u03b1\u03c2, \u03c7\u03c9\u03c1\u03af\u03c2 \u03cc\u03bc\u03c9\u03c2 \u03b1\u03ba\u03cc\u03bc\u03b1 \u03bd\u03b1 \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03b1\u03c1\u03ba\u03b5\u03c4\u03ad\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03b1\u03c6\u03bf\u03c1\u03bf\u03cd\u03bd \u03c3\u03c4\u03b7 \u0398\u0391 (92).<\/p>\n

            \u039f\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc\u03c4\u03b5\u03c1\u03bf\u03b9 \u03c0\u03b5\u03c1\u03b9\u03b2\u03b1\u03bb\u03bb\u03bf\u03bd\u03c4\u03b9\u03ba\u03bf\u03af \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03c3\u03c5\u03bc\u03b2\u03ac\u03bb\u03bb\u03bf\u03c5\u03bd \u03c3\u03c4\u03b7\u03bd \u03b1\u03b9\u03c4\u03b9\u03bf\u03c0\u03b1\u03b8\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 \u0398\u0391 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf \u03b9\u03ce\u03b4\u03b9\u03bf \u03ba\u03b1\u03b9 \u03c4\u03bf \u03ad\u03bd\u03c4\u03bf\u03bd\u03bf stress (90) \u03b5\u03bd\u03ce \u03c4\u03b1 \u03c4\u03b5\u03bb\u03b5\u03c5\u03c4\u03b1\u03af\u03b1 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03c0\u03bf\u03bb\u03bb\u03bf\u03af \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03ad\u03c2 \u03bc\u03b5\u03bb\u03b5\u03c4\u03bf\u03cd\u03bd \u03c4\u03b9\u03c2 \u03b5\u03c0\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c4\u03b7\u03c2 \u03ad\u03bb\u03bb\u03b5\u03b9\u03c8\u03b7\u03c2 \u03c3\u03b5\u03bb\u03b7\u03bd\u03af\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03c3\u03c5\u03bc\u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03ae\u03c2 \u03c4\u03bf\u03c5.<\/p>\n

            3.2.1. \u0399\u03ce\u03b4\u03b9\u03bf<\/b><\/h6>\n

            \u03a0\u03bf\u03bb\u03bb\u03ad\u03c2 \u03b5\u03c0\u03b9\u03b4\u03b7\u03bc\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c3\u03b5 \u03c0\u03b5\u03b9\u03c1\u03b1\u03bc\u03b1\u03c4\u03cc\u03b6\u03c9\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b1\u03bd\u03b1\u03b4\u03b5\u03af\u03be\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c5\u03c0\u03b5\u03c1\u03b2\u03bf\u03bb\u03b9\u03ba\u03ae \u03c0\u03c1\u03cc\u03c3\u03bb\u03b7\u03c8\u03b7 \u03b9\u03c9\u03b4\u03af\u03bf\u03c5 \u03c9\u03c2 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1 \u03c0\u03b1\u03b8\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1\u03c2 \u03c4\u03c9\u03bd \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03c9\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03bd\u03cc\u03c3\u03c9\u03bd (89,93). \u0391\u03c1\u03ba\u03b5\u03c4\u03bf\u03af \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03af \u03ad\u03c7\u03bf\u03c5\u03bd \u03c0\u03c1\u03bf\u03c4\u03b1\u03b8\u03b5\u03af \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03c4\u03c1\u03cc\u03c0\u03bf \u03bc\u03b5 \u03c4\u03bf\u03bd \u03bf\u03c0\u03bf\u03af\u03bf \u03c4\u03bf \u03b9\u03ce\u03b4\u03b9\u03bf \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c0\u03c1\u03bf\u03ac\u03b3\u03b5\u03b9 \u03c4\u03b9\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5\u03c2 \u03b1\u03c5\u03c4\u03ad\u03c2. \u0397 \u03c3\u03cd\u03bd\u03b4\u03b5\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b9\u03c9\u03b4\u03af\u03bf\u03c5 \u03bc\u03b5 \u03c4\u03b7 \u03b8\u03c5\u03c1\u03b5\u03bf\u03c3\u03c6\u03b1\u03b9\u03c1\u03af\u03bd\u03b7 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b1\u03bd\u03c4\u03b9\u03b3\u03bf\u03bd\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03ac \u03c4\u03b7\u03c2, \u03b1\u03c5\u03be\u03ac\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c0\u03b1\u03c1\u03ac\u03bb\u03bb\u03b7\u03bb\u03b1 \u03c4\u03b7 \u03c3\u03c5\u03b3\u03b3\u03ad\u03bd\u03b5\u03b9\u03ac \u03c4\u03b7\u03c2 \u03bc\u03b5 \u03c4\u03bf\u03bd TCR \u03ba\u03b1\u03b9 \u03b5\u03bd\u03b9\u03c3\u03c7\u03cd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1\u03c3\u03ae \u03c4\u03b7\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b1 APC \u03c3\u03c4\u03b1 \u03a4 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 (94). \u0391\u03c5\u03c4\u03cc \u03ad\u03c7\u03b5\u03b9 \u03c9\u03c2 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03b7\u03bd \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ce\u03bd \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03c4\u03b7\u03c2 \u03b8\u03c5\u03c1\u03b5\u03bf\u03c3\u03c6\u03b1\u03b9\u03c1\u03af\u03bd\u03b7\u03c2. \u0395\u03c0\u03af\u03c3\u03b7\u03c2 \u03b7 \u03bf\u03be\u03b5\u03af\u03b4\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b9\u03c9\u03b4\u03af\u03bf\u03c5 \u03b1\u03c0\u03cc \u03c4\u03b7 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae \u03c5\u03c0\u03b5\u03c1\u03bf\u03be\u03b5\u03b9\u03b4\u03ac\u03c3\u03b7 (TPO) \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03bc\u03b5\u03c3\u03bf\u03bb\u03b1\u03b2\u03b7\u03c4\u03ce\u03bd, \u03bf\u03b9 \u03bf\u03c0\u03bf\u03af\u03bf\u03b9 \u03ad\u03c7\u03bf\u03c5\u03bd \u03ac\u03bc\u03b5\u03c3\u03b7 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03c1\u03b5\u03c0\u03c4\u03b9\u03ba\u03ae \u03b4\u03c1\u03ac\u03c3\u03b7 \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03c4\u03c9\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd, \u03bb\u03cc\u03b3\u03c9 \u03bf\u03be\u03b5\u03af\u03b4\u03c9\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd \u03bc\u03b5\u03bc\u03b2\u03c1\u03b1\u03bd\u03b9\u03ba\u03ce\u03bd \u03bb\u03b9\u03c0\u03b9\u03b4\u03af\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03ce\u03bd \u03c4\u03bf\u03c5\u03c2 (95). \u03a4\u03ad\u03bb\u03bf\u03c2 \u03c4\u03bf \u03b9\u03ce\u03b4\u03b9\u03bf \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03b8\u03b5\u03c4\u03b9\u03ba\u03ae \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c3\u03c4\u03b7\u03bd \u03c9\u03c1\u03af\u03bc\u03b1\u03bd\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b4\u03b5\u03bd\u03b4\u03c1\u03b9\u03c4\u03b9\u03ba\u03ce\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd, \u03c3\u03c4\u03b7\u03bd \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b1\u03c1\u03b9\u03b8\u03bc\u03bf\u03cd \u03c4\u03c9\u03bd \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03bf\u03cd\u03bd\u03c4\u03c9\u03bd \u03a4 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b5\u03bd\u03af\u03c3\u03c7\u03c5\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae\u03c2 \u03b1\u03bd\u03bf\u03c3\u03bf\u03c3\u03c6\u03b1\u03b9\u03c1\u03b9\u03bd\u03ce\u03bd (2, 96). \u03a3\u03b5 \u03c0\u03b5\u03b9\u03c1\u03b1\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc \u03bc\u03bf\u03bd\u03c4\u03ad\u03bb\u03bf \u0397\u03a4 \u03b7 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03b9\u03c9\u03b4\u03af\u03bf\u03c5 \u03b5\u03c0\u03ac\u03b3\u03b5\u03b9 \u03c4\u03b7\u03bd \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b1\u03c0\u03bf\u03c0\u03c4\u03c9\u03c4\u03b9\u03ba\u03bf\u03cd \u03bc\u03bf\u03c1\u03af\u03bf\u03c5 TRAIL \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03c6\u03ac\u03bd\u03b5\u03b9\u03b1 \u03c4\u03cc\u03c3\u03bf \u03c4\u03c9\u03bd \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03c4\u03c9\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03b5\u03bd\u03ce \u03c4\u03b7\u03bd \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 DR5 \u03bc\u03cc\u03bd\u03bf \u03c3\u03b5 \u03b8\u03c5\u03c1\u03b5\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1, \u03ba\u03b1\u03b8\u03b9\u03c3\u03c4\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b1 \u03ad\u03c4\u03c3\u03b9 \u03b5\u03c5\u03ac\u03bb\u03c9\u03c4\u03b1 \u03c3\u03b5 \u03b1\u03c0\u03cc\u03c0\u03c4\u03c9\u03c3\u03b7 \u03bc\u03ad\u03c3\u03c9 \u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7\u03c2 \u03bc\u03b5 \u03c4\u03bf TRAIL (97). <\/b>\u0391\u03c0\u03cc \u03c4\u03b7\u03bd \u03ac\u03bb\u03bb\u03b7 \u03c0\u03bb\u03b5\u03c5\u03c1\u03ac, \u03b7 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 TRAIL \u03c3\u03c4\u03b1 \u03b8\u03c5\u03c1\u03b5\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03b5\u03af\u03bb\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03b7 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03af\u03c4\u03b9\u03b4\u03b1 (98) \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03b1\u03c5\u03be\u03ae\u03c3\u03b5\u03b9 \u03c4\u03bf\u03bd \u03b1\u03c1\u03b9\u03b8\u03bc\u03cc \u03c4\u03c9\u03bd Tregs (99).<\/p>\n

            3.2.2. Stress<\/b><\/h6>\n

            \u039f\u03b9 \u03b1\u03c1\u03c7\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03c3\u03c5\u03bd\u03ad\u03b4\u03b5\u03b1\u03bd \u03c4\u03bf stress \u03bc\u03b5 \u03c4\u03b7 \u0398\u0391 \u03b1\u03c6\u03bf\u03c1\u03bf\u03cd\u03c3\u03b1\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 GD \u03c0\u03bf\u03c5 \u03b1\u03bd\u03ad\u03c6\u03b5\u03c1\u03b1\u03bd \u03ba\u03ac\u03c0\u03bf\u03b9\u03bf \u03ad\u03bd\u03c4\u03bf\u03bd\u03bf \u03c3\u03c4\u03c1\u03b5\u03c3\u03bf\u03b3\u03cc\u03bd\u03bf \u03b3\u03b5\u03b3\u03bf\u03bd\u03cc\u03c2 \u03c0\u03c1\u03b9\u03bd \u03c4\u03b7\u03bd \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5 (100,101). \u03a3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03ae\u03c4\u03b1\u03bd \u03b7 \u03c0\u03b1\u03c1\u03b1\u03c4\u03ae\u03c1\u03b7\u03c3\u03b7 \u03c0\u03c9\u03c2 \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7 \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03c4\u03bf\u03c5 \u03c0\u03bf\u03bb\u03ad\u03bc\u03bf\u03c5 \u03c3\u03c4\u03b7 \u03a3\u03b5\u03c1\u03b2\u03af\u03b1 (1992-1995) \u03b7 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03b7\u03c2 GD \u03b1\u03c5\u03be\u03ae\u03b8\u03b7\u03ba\u03b5 \u03b5\u03bd\u03ce \u03ad\u03c9\u03c2 \u03c4\u03cc\u03c4\u03b5 \u03c0\u03b1\u03c1\u03ad\u03bc\u03b5\u03bd\u03b5 \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03ae \u03b1\u03c0\u03cc \u03c4\u03bf 1971 (102). \u0391\u03c1\u03ba\u03b5\u03c4\u03bf\u03af \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03af \u03ad\u03c7\u03bf\u03c5\u03bd \u03c0\u03c1\u03bf\u03c4\u03b1\u03b8\u03b5\u03af \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 stress \u03c3\u03c4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c0\u03bf\u03c5 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03ad\u03c7\u03bf\u03c5\u03bd \u03c3\u03c4\u03b7\u03bd \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03bf\u03b3\u03b9\u03ba\u03ae \u03b1\u03c0\u03ac\u03bd\u03c4\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u0398\u0391. T\u03b1 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c4\u03bf\u03c5 \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03bf\u03cd \u03c3\u03c5\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2 \u03b5\u03ba\u03c6\u03c1\u03ac\u03b6\u03bf\u03c5\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03b5\u03af\u03c2 \u03b3\u03bb\u03c5\u03ba\u03bf\u03ba\u03bf\u03c1\u03c4\u03b9\u03ba\u03bf\u03b5\u03b9\u03b4\u03ce\u03bd \u03ba\u03b1\u03b9 \u03ba\u03b1\u03c4\u03b5\u03c7\u03bf\u03bb\u03b1\u03bc\u03b9\u03bd\u03ce\u03bd. \u03a4\u03b1 \u03b3\u03bb\u03c5\u03ba\u03bf\u03ba\u03bf\u03c1\u03c4\u03b9\u03ba\u03bf\u03b5\u03b9\u03b4\u03ae \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae IL-12 \u03b1\u03c0\u03cc \u03c4\u03b1 APC \u03ba\u03b1\u03b9 \u03b1\u03c5\u03be\u03ac\u03bd\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae IL-4, IL-10 \u03b1\u03c0\u03cc \u03c4\u03b1 Th2 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1, \u03b5\u03c5\u03bf\u03b4\u03ce\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03ad\u03c4\u03c3\u03b9 \u03c4\u03b7 \u03c7\u03c5\u03bc\u03b9\u03ba\u03ae \u03b1\u03bd\u03bf\u03c3\u03af\u03b1 (103). \u0395\u03c0\u03af\u03c3\u03b7\u03c2, \u03c4\u03b1 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03ba\u03b1\u03c4\u03b5\u03c7\u03bf\u03bb\u03b1\u03bc\u03b9\u03bd\u03ce\u03bd, \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf stress, \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae IL-12 \u03ba\u03b1\u03b9 TNF-a \u03b5\u03bd\u03ce \u03b1\u03c5\u03be\u03ac\u03bd\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u0399FN-\u03b3 \u03b1\u03c0\u03cc \u03c4\u03b1 APC. \u0395\u03c0\u03b9\u03c0\u03c1\u03cc\u03c3\u03b8\u03b5\u03c4\u03b1, \u03c4\u03b1 \u03b4\u03b9\u03b5\u03b3\u03b5\u03c1\u03bc\u03ad\u03bd\u03b1 \u03b1\u03c0\u03cc \u03ba\u03b1\u03c4\u03b5\u03c7\u03bf\u03bb\u03b1\u03bc\u03af\u03bd\u03b5\u03c2 \u03b4\u03b5\u03bd\u03b4\u03c1\u03b9\u03c4\u03b9\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b5\u03c5\u03bd\u03bf\u03bf\u03cd\u03bd \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03ac\u03b3\u03c9\u03b3\u03ae IL-4 \u03ba\u03b1\u03b9 IL-17 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03a4 effectors \u03b5\u03c5\u03bf\u03b4\u03ce\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7 \u03b4\u03b7\u03bc\u03b9\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03b5\u03bd\u03cc\u03c2 Th2\/Th17 \u03bc\u03b9\u03ba\u03c1\u03bf\u03c0\u03b5\u03c1\u03b9\u03b2\u03ac\u03bb\u03bb\u03bf\u03bd\u03c4\u03bf\u03c2 (104). \u038c\u03bb\u03b1 \u03c4\u03b1 \u03c0\u03b1\u03c1\u03b1\u03c0\u03ac\u03bd\u03c9 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c9\u03c2 \u03c3\u03c5\u03bd\u03ad\u03c0\u03b5\u03b9\u03b1 \u03c4\u03b7 \u03b4\u03b7\u03bc\u03b9\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03c3\u03c5\u03bd\u03b8\u03b7\u03ba\u03ce\u03bd \u03c0\u03bf\u03c5 \u03b5\u03c5\u03bd\u03bf\u03bf\u03cd\u03bd \u03c4\u03b7\u03bd Th2 \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b1\u03c0\u03ac\u03bd\u03c4\u03b7\u03c3\u03b7, \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03bc\u03b5 \u03c4\u03b7 \u03c3\u03b5\u03b9\u03c1\u03ac \u03c4\u03b7\u03c2 \u03b5\u03c5\u03bf\u03b4\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03ba\u03c1\u03ac\u03c4\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c7\u03c5\u03bc\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03bf\u03c3\u03af\u03b1\u03c2, \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ce\u03bd \u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7 GD.<\/p>\n

            \u0391\u03ba\u03cc\u03bc\u03b1, \u03b7 \u03ba\u03b1\u03c4\u03ac\u03b8\u03bb\u03b9\u03c8\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03bf stress \u03b5\u03c5\u03bd\u03bf\u03bf\u03cd\u03bd \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae IL-6 \u03b1\u03c0\u03cc \u03c4\u03b1 APC (105) \u03b5\u03bd\u03ce \u03b7 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u039dF-kb (\u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03bf\u03b9\u03c7\u03b7 \u03bc\u03b5 \u03b1\u03c5\u03c4\u03ae \u03c0\u03bf\u03c5 \u03c3\u03c5\u03bc\u03b2\u03b1\u03af\u03bd\u03b5\u03b9 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03bf \u03bf\u03be\u03b5\u03b9\u03b4\u03c9\u03c4\u03b9\u03ba\u03cc \u03c3\u03c4\u03c1\u03b5\u03c2) \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bc\u03b1\u03ba\u03c1\u03bf\u03c0\u03c1\u03cc\u03b8\u03b5\u03c3\u03bc\u03b1 \u03bd\u03b1 \u03bf\u03b4\u03b7\u03b3\u03ae\u03c3\u03b5\u03b9 \u03c3\u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03ba\u03c5\u03c4\u03bf\u03ba\u03b9\u03bd\u03ce\u03bd \u03c0\u03bf\u03c5 \u03c3\u03c5\u03bc\u03b2\u03ac\u03bb\u03bb\u03bf\u03c5\u03bd \u03c3\u03c4\u03b7\u03bd \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u0398\u0391 (106). \u03a4\u03ad\u03bb\u03bf\u03c2 \u03b1\u03be\u03b9\u03bf\u03c3\u03b7\u03bc\u03b5\u03af\u03c9\u03c4\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03b7 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c0\u03b1\u03c1\u03b1\u03c4\u03ae\u03c1\u03b7\u03c3\u03b7 \u03c0\u03c9\u03c2 \u03b7 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03b2\u03b5\u03bd\u03b6\u03bf\u03b4\u03b9\u03b1\u03b6\u03b5\u03c0\u03b9\u03bd\u03ce\u03bd \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bc\u03b5\u03b9\u03ce\u03c3\u03b5\u03b9 \u03c4\u03bf \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03c5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03ae\u03c2 \u03c4\u03b7\u03c2 GD \u03c3\u03b5 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 (107).<\/p>\n

            3.2.3. \u03a3\u03b5\u03bb\u03ae\u03bd\u03b9\u03bf<\/b><\/h6>\n

            \u039f \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03ae\u03c2 \u03b1\u03b4\u03ad\u03bd\u03b1\u03c2 \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03c0\u03b5\u03c1\u03b9\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03bf\u03c5 \u03b9\u03c7\u03bd\u03bf\u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03bf\u03c5 \u03c3\u03b5\u03bb\u03ae\u03bd\u03b9\u03bf \u03c3\u03c4\u03bf\u03bd \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03b9\u03bd\u03bf \u03bf\u03c1\u03b3\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc, \u03bb\u03cc\u03b3\u03c9 \u03c4\u03c9\u03bd \u03c3\u03b5\u03bb\u03b7\u03bd\u03bf\u03c0\u03c1\u03c9\u03c4\u03b5\u03b9\u03bd\u03ce\u03bd \u03c0\u03bf\u03c5 \u03c0\u03b5\u03c1\u03b9\u03ad\u03c7\u03b5\u03b9 (\u03b1\u03c0\u03bf\u03b9\u03c9\u03b4\u03b9\u03bd\u03ac\u03c3\u03b5\u03c2 1-3). \u0395\u03bb\u03ac\u03c7\u03b9\u03c3\u03c4\u03b5\u03c2 \u03c0\u03bf\u03c3\u03cc\u03c4\u03b7\u03c4\u03b5\u03c2 \u03c3\u03b5\u03bb\u03b7\u03bd\u03af\u03bf\u03c5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c1\u03ba\u03b5\u03c4\u03ad\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b5\u03c0\u03b1\u03c1\u03ba\u03ae \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03c4\u03c9\u03bd \u03b1\u03c0\u03bf\u03b9\u03c9\u03b4\u03b9\u03bd\u03b1\u03c3\u03ce\u03bd. \u0397 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03c3\u03b5\u03bb\u03b7\u03bd\u03af\u03bf\u03c5 \u03bf\u03b4\u03ae\u03b3\u03b7\u03c3\u03b5 \u03c3\u03b5 \u03bc\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03b1\u03c0\u03b5\u03bb\u03b5\u03c5\u03b8\u03ad\u03c1\u03c9\u03c3\u03b7 IL-2, IFN-g, TNF-a \u03b1\u03c0\u03cc \u03c4\u03b1 \u03c0\u03b5\u03c1\u03b9\u03c6\u03b5\u03c1\u03b9\u03ba\u03ac \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b5\u03c5\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03bc\u03b5 \u0397\u03a4, \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c3\u03c5\u03c3\u03c7\u03b5\u03c4\u03af\u03c3\u03c4\u03b7\u03ba\u03b5 \u03bc\u03b5 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c4\u03af\u03c4\u03bb\u03bf\u03c5 \u03b1\u03bd\u03c4\u03b9-TPO (108). \u0395\u03c0\u03af\u03c3\u03b7\u03c2 \u03bc\u03b9\u03b1 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03b1\u03bd\u03b1\u03ba\u03ac\u03bb\u03c5\u03c8\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03c9\u03c2 \u03c4\u03bf \u03c3\u03b5\u03bb\u03ae\u03bd\u03b9\u03bf \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03bf\u03bd \u03b1\u03c1\u03b9\u03b8\u03bc\u03cc Tregs \u03c3\u03b5 \u03bc\u03bf\u03bd\u03c4\u03ad\u03bb\u03bf \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03b7\u03c2 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03af\u03c4\u03b9\u03b4\u03b1\u03c2 NOD.H-2(h4) \u03c0\u03bf\u03bd\u03c4\u03b9\u03ba\u03ce\u03bd (109). \u039c\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b4\u03b5\u03af\u03be\u03b5\u03b9 \u03c0\u03c9\u03c2 \u03b7 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03c3\u03b5\u03bb\u03b7\u03bd\u03af\u03bf\u03c5 \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03c9\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03ba\u03b1\u03b9 \u03b2\u03b5\u03bb\u03c4\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c5\u03c0\u03b5\u03c1\u03b7\u03c7\u03bf\u03b3\u03c1\u03b1\u03c6\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03c4\u03bf\u03c5 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03bf\u03cd\u03c2 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u0397\u03a4 \u03ba\u03b1\u03b9 \u03ad\u03b3\u03ba\u03c5\u03b5\u03c2 \u03b3\u03c5\u03bd\u03b1\u03af\u03ba\u03b5\u03c2 \u03bc\u03b5 \u03b8\u03b5\u03c4\u03b9\u03ba\u03ac anti-TPO \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 (110-112) \u0395\u03c0\u03af\u03c3\u03b7\u03c2 \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2 \u03c0\u03c9\u03c2 \u03c4\u03bf \u03c3\u03b5\u03bb\u03ae\u03bd\u03b9\u03bf \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03af\u03c4\u03b9\u03b4\u03b1\u03c2 \u03c4\u03b7\u03c2 \u03bb\u03bf\u03c7\u03b5\u03af\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03c5\u03c0\u03bf\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03c3\u03bc\u03bf\u03cd \u03b5\u03bd\u03ce \u03b2\u03bf\u03b7\u03b8\u03ac \u03c3\u03c4\u03b7\u03bd \u03c4\u03b1\u03c7\u03cd\u03c4\u03b5\u03c1\u03b7 \u03b5\u03c0\u03af\u03c4\u03b5\u03c5\u03be\u03b7 \u03b5\u03c5\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03c3\u03bc\u03bf\u03cd \u03c3\u03c4\u03b7 GD \u03ba\u03b1\u03b9 \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c0\u03c9\u03c2 \u03ad\u03c7\u03b5\u03b9 \u03b5\u03c5\u03bd\u03bf\u03ca\u03ba\u03ae \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c3\u03c4\u03b7\u03bd \u03ae\u03c0\u03b9\u03b1 \u03bf\u03c6\u03b8\u03b1\u03bb\u03bc\u03bf\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1. \u03a9\u03c3\u03c4\u03cc\u03c3\u03bf \u03c0\u03b1\u03c1\u03ac \u03c4\u03b9\u03c2 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03ae\u03c3\u03b5\u03b9\u03c2 \u03b1\u03c5\u03c4\u03ad\u03c2, \u03b7 \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03c3\u03b5\u03bb\u03b7\u03bd\u03af\u03bf\u03c5 \u03c3\u03c4\u03b7 \u0398\u0391 \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b5\u03c2, \u03b4\u03b9\u03c0\u03bb\u03ad\u03c2-\u03c4\u03c5\u03c6\u03bb\u03ad\u03c2 \u03c4\u03c5\u03c7\u03b1\u03b9\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b5\u03c2 (RCT) \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03c5\u03c4\u03cc\u03c2 \u03ac\u03bb\u03bb\u03c9\u03c3\u03c4\u03b5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03bf \u03bb\u03cc\u03b3\u03bf\u03c2 \u03c0\u03bf\u03c5 \u03b7 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03c3\u03b5\u03bb\u03b7\u03bd\u03af\u03bf\u03c5 \u03b4\u03b5 \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b9\u03c2 \u03ba\u03b1\u03c4\u03b5\u03c5\u03b8\u03c5\u03bd\u03c4\u03ae\u03c1\u03b9\u03b5\u03c2 \u03bf\u03b4\u03b7\u03b3\u03af\u03b5\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03c4\u03b7\u03c2 \u0398\u0391.<\/p>\n

            3.3. <\/b>Micro<\/b>–<\/b>RNA<\/b><\/b><\/h5>\n

            \u0391\u03c0\u03bf\u03c4\u03b5\u03bb\u03bf\u03cd\u03bd \u03bc\u03b9\u03b1 \u03bd\u03ad\u03b1 \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b1 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03b1\u03bb\u03c4\u03b9\u03ba\u03ce\u03bd \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03c4\u03ce\u03bd \u03c4\u03b7\u03c2 \u03b3\u03bf\u03bd\u03b9\u03b4\u03b9\u03b1\u03ba\u03ae\u03c2 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7\u03c2. \u03a0\u03c1\u03cc\u03c3\u03c6\u03b1\u03c4\u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03ad\u03b4\u03b5\u03b9\u03be\u03b5 \u03c0\u03c9\u03c2 \u03b7 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03c9\u03bd miRNA 154*, 376b \u03ba\u03b1\u03b9 431* \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03c3\u03b5 \u03c0\u03b5\u03c1\u03b9\u03c6\u03b5\u03c1\u03b9\u03ba\u03ac \u03bc\u03bf\u03bd\u03bf\u03c0\u03cd\u03c1\u03b7\u03bd\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03bc\u03b5 GD \u03b5\u03bd\u03ce \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 \u03bc\u03b5\u03b8\u03b9\u03bc\u03b1\u03b6\u03cc\u03bb\u03b7 (113). \u03a3\u03c4\u03b1 \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1-\u03c3\u03c4\u03cc\u03c7\u03bf\u03c5\u03c2 (target genes) \u03c4\u03c9\u03bd miRNA \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c7\u03c5\u03bc\u03bf\u03ba\u03af\u03bd\u03b5\u03c2, \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 \u03c0\u03bf\u03c5 \u03b5\u03bc\u03c0\u03bb\u03ad\u03ba\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03c3\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03bf\u03c4\u03b9\u03ba\u03ac \u03bc\u03bf\u03bd\u03bf\u03c0\u03ac\u03c4\u03b9\u03b1 \u03ba\u03c5\u03c4\u03bf\u03ba\u03b9\u03bd\u03ce\u03bd \u03ba\u03b1\u03b9 \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae\u03c2 \u03b1\u03c0\u03ac\u03bd\u03c4\u03b7\u03c3\u03b7\u03c2, \u03c3\u03c4\u03bf \u03bc\u03bf\u03bd\u03bf\u03c0\u03ac\u03c4\u03b9 \u03c4\u03c9\u03bd G \u03c0\u03c1\u03c9\u03c4\u03b5\u03b9\u03bd\u03ce\u03bd \u03ba\u03b1\u03b9 \u03c3\u03c4\u03bf Wnt \u03c3\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03bf\u03c4\u03b9\u03ba\u03cc \u03bc\u03bf\u03bd\u03bf\u03c0\u03ac\u03c4\u03b9. \u038c\u03c3\u03bf\u03bd \u03b1\u03c6\u03bf\u03c1\u03ac \u03c3\u03c4\u03bf \u03c1\u03cc\u03bb\u03bf \u03c4\u03bf\u03c5\u03c2 \u03c3\u03c4\u03b7\u03bd \u03b1\u03b9\u03c4\u03b9\u03bf\u03c0\u03b1\u03b8\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 \u0398\u0391, \u03ad\u03c7\u03b5\u03b9 \u03b4\u03b9\u03b1\u03c4\u03c5\u03c0\u03c9\u03b8\u03b5\u03af \u03b7 \u03c5\u03c0\u03cc\u03b8\u03b5\u03c3\u03b7 \u03c0\u03c9\u03c2 \u03b7 \u03bc\u03b5\u03af\u03c9\u03c3\u03ae \u03c4\u03bf\u03c5\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03c5\u03bf\u03b4\u03ce\u03bd\u03b5\u03b9 \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03b1\u03c0\u03b1\u03bd\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2 \u03c0\u03bf\u03c5 \u03bf\u03b4\u03b7\u03b3\u03bf\u03cd\u03bd \u03c3\u03b5 GD. \u03a0\u03bf\u03bb\u03cd \u03b5\u03bd\u03b4\u03b9\u03b1\u03c6\u03ad\u03c1\u03bf\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03b4\u03cd\u03bf \u03b1\u03c0\u03cc \u03b1\u03c5\u03c4\u03ac \u03c4\u03b1 mi-RNA \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c3\u03c4\u03b5\u03c1\u03cc\u03bc\u03bf\u03c1\u03c6\u03b1 (starform) (154*, 431*) \u03c0\u03bf\u03c5 \u03bc\u03ad\u03c7\u03c1\u03b9 \u03c0\u03c1\u03cc\u03c3\u03c6\u03b1\u03c4\u03b1 \u03b8\u03b5\u03c9\u03c1\u03bf\u03cd\u03bd\u03c4\u03b1\u03bd \u03b1\u03bd\u03b5\u03bd\u03b5\u03c1\u03b3\u03ac \u03bc\u03b7 \u03ba\u03c9\u03b4\u03b9\u03ba\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1 (non-coding) \u03bc\u03cc\u03c1\u03b9\u03b1 RNA \u03c4\u03b1 \u03bf\u03c0\u03bf\u03af\u03b1 \u03b1\u03c0\u03bf\u03b4\u03bf\u03bc\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9. \u03a9\u03c3\u03c4\u03cc\u03c3\u03bf \u03c4\u03b5\u03bb\u03b5\u03c5\u03c4\u03b1\u03af\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03b4\u03b5\u03af\u03c7\u03bd\u03bf\u03c5\u03bd \u03c0\u03c9\u03c2 \u03bf \u03c1\u03cc\u03bb\u03bf\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b9\u03bf \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc\u03c2 \u03b1\u03c0\u2019\u03cc\u03c4\u03b9 \u03b1\u03c1\u03c7\u03b9\u03ba\u03ac \u03c0\u03b9\u03c3\u03c4\u03b5\u03c5\u03cc\u03c4\u03b1\u03bd \u03bc\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c0\u03c9\u03c2 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03b9\u03ba\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03bd\u03b1 \u03b5\u03c0\u03b9\u03b4\u03c1\u03bf\u03cd\u03bd \u03c3\u03c4\u03b7 \u03b3\u03bf\u03bd\u03b9\u03b4\u03b9\u03b1\u03ba\u03ae \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03ce\u03bd \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03c9\u03bd (114,115).<\/p>\n

            \u00a03.4. <\/b>DAMPs<\/b> (<\/b>danger<\/b> <\/b>associated<\/b> <\/b>molecular<\/b> <\/b>patterns<\/b>)<\/b><\/h5>\n

            \u039c\u03b9\u03b1 <\/b>\u03c0\u03c1\u03cc\u03c3\u03c6\u03b1\u03c4\u03b7 \u03b8\u03b5\u03c9\u03c1\u03af\u03b1 (danger hypothesis) \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u0398\u0391 \u03b1\u03bd\u03b1\u03b4\u03b5\u03b9\u03ba\u03bd\u03cd\u03b5\u03b9 \u03c4\u03b7 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1 \u03c4\u03c9\u03bd DAMPs (danger associated molecular patterns). \u03a4\u03b1 DAMPs \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03bf\u03cd\u03bd \u03b5\u03bd\u03b4\u03bf\u03b3\u03b5\u03bd\u03ae \u03bc\u03cc\u03c1\u03b9\u03b1 (\u03c4\u03bc\u03ae\u03bc\u03b1\u03c4\u03b1 \u03b3\u03b5\u03bd\u03c9\u03bc\u03b9\u03ba\u03bf\u03cd DNA, heat shock \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2, \u03bf\u03c5\u03c1\u03b9\u03ba\u03cc \u03bf\u03be\u03cd, \u03ba\u03bf\u03bb\u03bb\u03b1\u03b3\u03cc\u03bd\u03bf, \u03c5\u03b1\u03bb\u03bf\u03c5\u03c1\u03bf\u03bd\u03b9\u03ba\u03cc \u03bf\u03be\u03cd) \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03b8\u03bd\u03ae\u03c3\u03ba\u03c9\u03bd\u03c4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1. \u0395\u03bd\u03b4\u03b9\u03b1\u03c6\u03ad\u03c1\u03bf\u03bd \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03b9\u03ac\u03b6\u03b5\u03b9 \u03c4\u03bf \u03b3\u03b5\u03b3\u03bf\u03bd\u03cc\u03c2 \u03c0\u03c9\u03c2 \u03c3\u03c4\u03b1 \u03b8\u03c5\u03c1\u03b5\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b5\u03ba\u03c6\u03c1\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 Toll-like \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03b5\u03af\u03c2, \u03bf\u03b9 \u03bf\u03c0\u03bf\u03af\u03bf\u03b9 \u03b1\u03bd\u03b1\u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03bf\u03c5\u03bd \u03c4\u03b1 DAMPs. \u039f\u03b9 \u03ba\u03b1\u03c4\u03b1\u03c4\u03b5\u03c4\u03bc\u03b7\u03bc\u03ad\u03bd\u03b5\u03c2 \u03b4\u03b9\u03c0\u03bb\u03ad\u03c2 \u03ad\u03bb\u03b9\u03ba\u03b5\u03c2 \u03c4\u03bf\u03c5 DNA \u03b4\u03cd\u03bd\u03b1\u03bd\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03b5\u03b9\u03c3\u03ad\u03c1\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03cc\u03c0\u03bb\u03b1\u03c3\u03bc\u03b1 \u03c4\u03c9\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03cc\u03c0\u03bf\u03c5 \u03b1\u03bd\u03b9\u03c7\u03bd\u03b5\u03cd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc DNA-sens\u03bfrs (\u03b9\u03c3\u03c4\u03cc\u03bd\u03b7 \u03972\u0392) \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03c3\u03c5\u03bd\u03ad\u03c7\u03b5\u03b9\u03b1 \u03bd\u03b1 \u03b5\u03c0\u03ac\u03b3\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u039c\u0397C-II, \u03c3\u03c5\u03bd\u03b4\u03b9\u03b5\u03b3\u03b5\u03c1\u03c4\u03b9\u03ba\u03ce\u03bd \u03bc\u03bf\u03c1\u03af\u03c9\u03bd \u03ba\u03b1\u03b9 \u03b9\u03bd\u03c4\u03b5\u03c1\u03c6\u03b5\u03c1\u03cc\u03bd\u03b7\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03b8\u03c5\u03c1\u03b5\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c0\u03c5\u03c1\u03bf\u03b4\u03bf\u03c4\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7\u03bd \u03ad\u03bd\u03b1\u03c1\u03be\u03b7 \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae\u03c2 \u03b1\u03c0\u03ac\u03bd\u03c4\u03b7\u03c3\u03b7\u03c2. \u03a3\u03c4\u03bf \u03b8\u03c5\u03c1\u03b5\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03bf \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd, \u03bc\u03b5 \u03c4\u03bf\u03bd \u03af\u03b4\u03b9\u03bf \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc, \u03bd\u03b1 \u03b5\u03b9\u03c3\u03ad\u03c1\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03b1 (\u03c0.\u03c7 TSH-R) \u03b1\u03c0\u03cc \u03ba\u03b1\u03c4\u03b5\u03c3\u03c4\u03c1\u03b1\u03bc\u03bc\u03ad\u03bd\u03b1 \u03b3\u03b5\u03b9\u03c4\u03bf\u03bd\u03b9\u03ba\u03ac \u03b8\u03c5\u03c1\u03b5\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c4\u03b1 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c3\u03c4\u03b7 \u03c3\u03c5\u03bd\u03ad\u03c7\u03b5\u03b9\u03b1 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03b9\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf MHC-II \u03c4\u03c9\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c3\u03c4\u03b1 CD4 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 (116).<\/p>\n

            3.5. \u039c\u03b9\u03ba\u03c1\u03bf\u03c7\u03b9\u03bc\u03b1\u03b9\u03c1\u03b9\u03c3\u03bc\u03cc\u03c2<\/b><\/h5>\n

            \u039f \u03cc\u03c1\u03bf\u03c2 \u03bc\u03b9\u03ba\u03c1\u03bf\u03c7\u03b9\u03bc\u03b1\u03b9\u03c1\u03b9\u03c3\u03bc\u03cc\u03c2 \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03ac\u03c6\u03b5\u03b9 \u03c4\u03b7 \u03c3\u03c5\u03bd\u03cd\u03c0\u03b1\u03c1\u03be\u03b7 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ac \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ce\u03bd \u03ba\u03b1\u03b9 \u03b4\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03ce\u03bd \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03ce\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ad\u03c1\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03b4\u03cd\u03bf \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ac \u03ac\u03c4\u03bf\u03bc\u03b1. \u03a3\u03b5 \u03ba\u03ac\u03c0\u03bf\u03b9\u03b5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c0\u03c1\u03cc\u03ba\u03b5\u03b9\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03bc\u03b5\u03c4\u03b1\u03c6\u03bf\u03c1\u03ac \u03bc\u03b9\u03ba\u03c1\u03bf\u03cd \u03b1\u03c1\u03b9\u03b8\u03bc\u03bf\u03cd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03b1\u03c0\u03cc \u03ad\u03bd\u03b1 \u03ac\u03c4\u03bf\u03bc\u03bf \u03c3\u03b5 \u03ad\u03bd\u03b1 \u03ac\u03bb\u03bb\u03bf \u03c0.\u03c7. \u03c3\u03b5 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03bc\u03b5\u03c4\u03ac\u03b3\u03b3\u03b9\u03c3\u03b7\u03c2 \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2 \u03ae \u03bc\u03b5\u03c4\u03b1\u03bc\u03cc\u03c3\u03c7\u03b5\u03c5\u03c3\u03b7\u03c2 \u03bf\u03c1\u03b3\u03ac\u03bd\u03bf\u03c5, \u03b5\u03bd\u03ce \u03c0\u03b9\u03bf \u03c3\u03c5\u03c7\u03bd\u03ac \u03b1\u03c6\u03bf\u03c1\u03ac \u03c3\u03c4\u03b7 \u03bc\u03b5\u03c4\u03b1\u03c6\u03bf\u03c1\u03ac \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03b1\u03c0\u03cc \u03c4\u03bf \u03ad\u03bc\u03b2\u03c1\u03c5\u03bf \u03c3\u03c4\u03b7\u03bd \u03ad\u03b3\u03ba\u03c5\u03bf \u03b3\u03c5\u03bd\u03b1\u03af\u03ba\u03b1 \u03bc\u03ad\u03c3\u03c9 \u03c4\u03bf\u03c5 \u03c0\u03bb\u03b1\u03ba\u03bf\u03cd\u03bd\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03c1\u03bf\u03c6\u03b1. \u039f \u03bc\u03b9\u03ba\u03c1\u03bf\u03c7\u03b9\u03bc\u03b1\u03b9\u03c1\u03b9\u03c3\u03bc\u03cc\u03c2 \u03b5\u03bc\u03b2\u03c1\u03c5\u03b9\u03ba\u03ce\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03b1\u03bd\u03b1\u03c6\u03ad\u03c1\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b1\u03bd\u03af\u03c7\u03bd\u03b5\u03c5\u03c3\u03b7 \u03b5\u03bc\u03b2\u03c1\u03c5\u03b9\u03ba\u03ce\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c3\u03c4\u03bf \u03c0\u03b5\u03c1\u03b9\u03c6\u03b5\u03c1\u03b9\u03ba\u03cc \u03b1\u03af\u03bc\u03b1, \u03c4\u03bf\u03c5\u03c2 \u03bb\u03b5\u03bc\u03c6\u03b1\u03b4\u03ad\u03bd\u03b5\u03c2 \u03ae \u03c4\u03bf\u03c5\u03c2 \u03b9\u03c3\u03c4\u03bf\u03cd\u03c2 (\u03ba\u03b1\u03b9 \u03c3\u03c4\u03bf \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03ae) \u03c4\u03b7\u03c2 \u03bc\u03b7\u03c4\u03ad\u03c1\u03b1\u03c2, \u03b5\u03bd\u03ce \u03bf \u03bc\u03b9\u03ba\u03c1\u03bf\u03c7\u03b9\u03bc\u03b1\u03b9\u03c1\u03b9\u03c3\u03bc\u03cc\u03c2 \u03bc\u03b7\u03c4\u03c1\u03b9\u03ba\u03ce\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03b1\u03bd\u03b1\u03c6\u03ad\u03c1\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b1\u03bd\u03af\u03c7\u03bd\u03b5\u03c5\u03c3\u03b7 \u03bc\u03b7\u03c4\u03c1\u03b9\u03ba\u03ce\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c3\u03c4\u03bf \u03c0\u03b5\u03c1\u03b9\u03c6\u03b5\u03c1\u03b9\u03ba\u03cc \u03b1\u03af\u03bc\u03b1 \u03ae \u03c4\u03bf\u03c5\u03c2 \u03b9\u03c3\u03c4\u03bf\u03cd\u03c2 \u03c4\u03bf\u03c5 \u03b5\u03bc\u03b2\u03c1\u03cd\u03bf\u03c5. \u03a4\u03b1 \u03bc\u03b9\u03ba\u03c1\u03bf\u03c7\u03b9\u03bc\u03b1\u03b9\u03c1\u03b9\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03b5\u03c0\u03b9\u03b2\u03b9\u03ce\u03c3\u03bf\u03c5\u03bd \u03b3\u03b9\u03b1 \u03c0\u03bf\u03bb\u03bb\u03ad\u03c2 \u03b4\u03b5\u03ba\u03b1\u03b5\u03c4\u03af\u03b5\u03c2 \u03ae \u03b1\u03ba\u03cc\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03ba\u03b1\u03b8\u2019\u03cc\u03bb\u03b7 \u03c4\u03b7 \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 \u03b6\u03c9\u03ae\u03c2 \u03b5\u03bd\u03cc\u03c2 \u03b1\u03c4\u03cc\u03bc\u03bf\u03c5 (117). \u0388\u03c7\u03b5\u03b9 \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03b1\u03c6\u03b5\u03af \u03ba\u03b1\u03b9 \u03b7 \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03c4\u03b1 \u03b5\u03bc\u03b2\u03c1\u03c5\u03b9\u03ba\u03ac \u03bc\u03b9\u03ba\u03c1\u03bf\u03c7\u03b9\u03bc\u03b1\u03b9\u03c1\u03b9\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c0\u03bf\u03c5 \u03b1\u03bd\u03b9\u03c7\u03bd\u03b5\u03cd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03bc\u03b7\u03c4\u03ad\u03c1\u03b1 \u03cc\u03c7\u03b9 \u03bc\u03cc\u03bd\u03bf \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03bf\u03c5\u03bd \u03bc\u03b5\u03c4\u03ac \u03c4\u03bf\u03bd \u03c4\u03bf\u03ba\u03b5\u03c4\u03cc \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03bc\u03b5\u03c4\u03b1\u03c6\u03ad\u03c1\u03bf\u03bd\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03bf \u03b5\u03c0\u03cc\u03bc\u03b5\u03bd\u03bf \u03ad\u03bc\u03b2\u03c1\u03c5\u03bf \u03cc\u03c4\u03b1\u03bd \u03b7 \u03b3\u03c5\u03bd\u03b1\u03af\u03ba\u03b1 \u03bc\u03b5\u03af\u03bd\u03b5\u03b9 \u03be\u03b1\u03bd\u03ac \u03ad\u03b3\u03ba\u03c5\u03bf\u03c2 (118).<\/p>\n

            \u03a3\u03c4\u03b1 \u03b5\u03bc\u03b2\u03c1\u03c5\u03b9\u03ba\u03ac \u03bc\u03b9\u03ba\u03c1\u03bf\u03c7\u03b9\u03bc\u03b1\u03b9\u03c1\u03b9\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c4\u03c1\u03bf\u03c6\u03bf\u03b2\u03bb\u03ac\u03c3\u03c4\u03b5\u03c2, \u03a4 \u03ba\u03b1\u03b9 \u0392 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1, \u03bc\u03bf\u03bd\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1\/\u03bc\u03b1\u03ba\u03c1\u03bf\u03c6\u03ac\u03b3\u03b1 \u03ba\u03b1\u03b9 \u039d\u039a \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03b1\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03ac \u03ba\u03b1\u03b9 \u03bc\u03b5\u03c3\u03b5\u03b3\u03c7\u03c5\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03b1\u03c1\u03c7\u03ad\u03b3\u03bf\u03bd\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 (stem cells) (118,119). \u03a4\u03b1 \u03b1\u03c1\u03c7\u03ad\u03b3\u03bf\u03bd\u03b1 \u03b1\u03c5\u03c4\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd, \u03c3\u03b5 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2, \u03bd\u03b1 \u03bc\u03b5\u03c4\u03b1\u03bd\u03b1\u03c3\u03c4\u03b5\u03cd\u03bf\u03c5\u03bd \u03c3\u03b5 \u03cc\u03c1\u03b3\u03b1\u03bd\u03b1 \u03c0\u03bf\u03c5 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c5\u03c0\u03bf\u03c3\u03c4\u03b5\u03af \u03c4\u03c1\u03b1\u03cd\u03bc\u03b1 \u03ae \u03b2\u03bb\u03ac\u03b2\u03b7 \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9\/\u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b5\u03ba\u03b5\u03af, \u03b2\u03bf\u03b7\u03b8\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c3\u03c4\u03b7\u03bd \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03ce\u03c0\u03b9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b2\u03bb\u03b1\u03c0\u03c4\u03b9\u03ba\u03bf\u03cd \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03c9\u03bd \u03b5\u03c0\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03ce\u03bd \u03c4\u03bf\u03c5 (120,121). \u039f \u03c1\u03cc\u03bb\u03bf\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03c9\u03c3\u03c4\u03cc\u03c3\u03bf \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03c0\u03c1\u03bf\u03c3\u03c4\u03b1\u03c4\u03b5\u03c5\u03c4\u03b9\u03ba\u03cc\u03c2 \u03bc\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03b5\u03bc\u03b2\u03c1\u03c5\u03b9\u03ba\u03ac \u03bc\u03b9\u03ba\u03c1\u03bf\u03c7\u03b9\u03bc\u03b1\u03b9\u03c1\u03b9\u03ba\u03ac \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b1 \u03a4, \u039d\u039a \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03ba\u03b1\u03b9 \u03bc\u03bf\u03bd\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1\/\u03bc\u03b1\u03ba\u03c1\u03bf\u03c6\u03ac\u03b3\u03b1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03bc\u03c0\u03bb\u03ad\u03ba\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03ad\u03bd\u03b1\u03c1\u03be\u03b7 \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03c9\u03bd \u03bd\u03bf\u03c3\u03b7\u03bc\u03ac\u03c4\u03c9\u03bd \u03bc\u03ad\u03c3\u03c9 \u03c4\u03c9\u03bd \u03ba\u03c5\u03c4\u03bf\u03ba\u03b9\u03bd\u03ce\u03bd \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03c5\u03bd (allo-autoimmunity) \u03ae \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b1\u03bd\u03b1\u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c9\u03c2 \u2018\u2019\u03bc\u03b5\u03c1\u03b9\u03ba\u03ce\u03c2\u2019\u2019 \u03b5\u03be\u03c9\u03b3\u03b5\u03bd\u03ae \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03b7\u03bd \u03ad\u03bd\u03b1\u03c1\u03be\u03b7 \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae\u03c2 \u03b1\u03c0\u03ac\u03bd\u03c4\u03b7\u03c3\u03b7\u03c2 (auto-alloimmunity).<\/p>\n

            \u0397 \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03bf\u03c7\u03ae\u03c2 \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03c4\u03c9\u03bd \u03bc\u03b9\u03ba\u03c1\u03bf\u03c7\u03b9\u03bc\u03b1\u03b9\u03c1\u03b9\u03ba\u03ce\u03bd \u03b5\u03bc\u03b2\u03c1\u03c5\u03b9\u03ba\u03ce\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bf\u03c6\u03b5\u03af\u03bb\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03bc\u03bf\u03bd\u03ae \u03ba\u03b1\u03b9 \u03c9\u03c1\u03af\u03bc\u03b1\u03bd\u03c3\u03ae \u03c4\u03bf\u03c5\u03c2 \u03c3\u03c4\u03bf \u03b8\u03cd\u03bc\u03bf \u03c4\u03b7\u03c2 \u03b5\u03b3\u03ba\u03cd\u03bf\u03c5 \u03cc\u03c0\u03bf\u03c5 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03c1\u03ad\u03c6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03cc\u03c3\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03b4\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03ac \u03bd\u03b1 \u03c3\u03c4\u03c1\u03b1\u03c6\u03bf\u03cd\u03bd \u03b5\u03bd\u03b1\u03bd\u03c4\u03af\u03bf\u03bd \u03bc\u03b7\u03c4\u03c1\u03b9\u03ba\u03ce\u03bd \u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03c9\u03bd. \u0386\u03bb\u03bb\u03b7 \u03c5\u03c0\u03cc\u03b8\u03b5\u03c3\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03c9\u03c2 \u03bc\u03b7\u03c4\u03c1\u03b9\u03ba\u03ac \u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03b1 \u03c0\u03bf\u03c5 \u03c0\u03b5\u03c1\u03bd\u03bf\u03cd\u03bd \u03b1\u03c0\u03cc \u03c4\u03b7 \u03bc\u03b7\u03c4\u03ad\u03c1\u03b1 \u03c3\u03c4\u03bf \u03ad\u03bc\u03b2\u03c1\u03c5\u03bf \u03ad\u03c7\u03bf\u03c5\u03bd \u03c9\u03c2 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03b7 \u03b4\u03b7\u03bc\u03b9\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03b5\u03bc\u03b2\u03c1\u03c5\u03b9\u03ba\u03ce\u03bd \u03a4regs \u03c4\u03b1 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c3\u03c4\u03b7 \u03c3\u03c5\u03bd\u03ad\u03c7\u03b5\u03b9\u03b1 \u03c0\u03b5\u03c1\u03bd\u03bf\u03cd\u03bd \u03c3\u03c4\u03b7 \u03bc\u03b7\u03c4\u03ad\u03c1\u03b1 \u03cc\u03c0\u03bf\u03c5 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03bf\u03c5\u03bd \u03c4\u03bf \u03bc\u03b7\u03c4\u03c1\u03b9\u03ba\u03cc \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03c3\u03cd\u03c3\u03c4\u03b7\u03bc\u03b1 \u03ce\u03c3\u03c4\u03b5 \u03bd\u03b1 \u03bc\u03b7\u03bd \u03ba\u03b9\u03bd\u03b7\u03c4\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03b5\u03af \u03b5\u03bd\u03b1\u03bd\u03c4\u03af\u03bf\u03bd \u03c4\u03c9\u03bd \u03b5\u03bc\u03b2\u03c1\u03c5\u03b9\u03ba\u03ce\u03bd \u03bc\u03b9\u03ba\u03c1\u03bf\u03c7\u03b9\u03bc\u03b1\u03b9\u03c1\u03b9\u03ba\u03ce\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd (122).<\/p>\n

            \u039f \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c2 \u03c1\u03cc\u03bb\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03bc\u03b9\u03ba\u03c1\u03bf\u03c7\u03b9\u03bc\u03b1\u03b9\u03c1\u03b9\u03c3\u03bc\u03bf\u03cd \u03c3\u03c4\u03b7\u03bd \u03b1\u03b9\u03c4\u03b9\u03bf\u03c0\u03b1\u03b8\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 \u0398\u0391 \u03ad\u03c7\u03b5\u03b9 \u03bd\u03b1 \u03ba\u03ac\u03bd\u03b5\u03b9 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b1\u03c1\u03c7\u03b9\u03ba\u03ae \u03c0\u03b1\u03c1\u03b1\u03c4\u03ae\u03c1\u03b7\u03c3\u03b7 \u03c0\u03c9\u03c2 o \u03b1\u03c1\u03b9\u03b8\u03bc\u03cc\u03c2 \u03c4\u03c9\u03bd \u03bc\u03b9\u03ba\u03c1\u03bf\u03c7\u03b9\u03bc\u03b1\u03b9\u03c1\u03b9\u03ba\u03ce\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03cc\u03c3\u03bf \u03c0\u03c1\u03bf\u03c7\u03c9\u03c1\u03ac \u03b7 \u03ba\u03cd\u03b7\u03c3\u03b7 \u03b3\u03b5\u03b3\u03bf\u03bd\u03cc\u03c2 \u03c0\u03bf\u03c5 \u03c3\u03c5\u03bc\u03c0\u03af\u03c0\u03c4\u03b5\u03b9 \u03bc\u03b5 \u03c4\u03b7 \u03b2\u03b5\u03bb\u03c4\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u0398\u0391 \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7\u03bd \u03ba\u03cd\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b5\u03c0\u03b1\u03bd\u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03ae \u03c4\u03b7\u03c2 \u03bc\u03b5\u03c4\u03ac \u03c4\u03bf\u03bd \u03c4\u03bf\u03ba\u03b5\u03c4\u03cc. \u03a0\u03b9\u03bf \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03c0\u03b1\u03c1\u03b1\u03c4\u03ae\u03c1\u03b7\u03c3\u03b7 \u03c0\u03c9\u03c2 \u03c3\u03b5 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b5\u03af\u03c2 \u03b1\u03b4\u03ad\u03bd\u03b5\u03c2 \u03b3\u03c5\u03bd\u03b1\u03b9\u03ba\u03ce\u03bd \u03bc\u03b5 \u0397\u03a4 \u03ba\u03b1\u03b9 GD \u03ad\u03c7\u03b5\u03b9 \u03b2\u03c1\u03b5\u03b8\u03b5\u03af \u03b5\u03bd\u03c4\u03bf\u03bd\u03cc\u03c4\u03b5\u03c1\u03b7 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 \u03bc\u03b9\u03ba\u03c1\u03bf\u03c7\u03b9\u03bc\u03b1\u03b9\u03c1\u03b9\u03ba\u03ce\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c3\u03b5 \u03c3\u03c7\u03ad\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b1 \u03c5\u03b3\u03b9\u03ae \u03ac\u03c4\u03bf\u03bc\u03b1 (123). \u0391\u03ba\u03cc\u03bc\u03b1 \u03c0\u03b9\u03bf \u03b5\u03bd\u03b4\u03b9\u03b1\u03c6\u03ad\u03c1\u03bf\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03c9\u03c2 \u03c4\u03b1 \u03c0\u03c1\u03bf\u03b4\u03b9\u03b1\u03b8\u03b5\u03c3\u03b9\u03ba\u03ac \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 HLA-DQA1*501-DQB1*0201 \u03ba\u03b1\u03b9 DQB1*0301 \u03b1\u03c0\u03b1\u03bd\u03c4\u03ce\u03bd\u03c4\u03b1\u03b9 \u03c0\u03b9\u03bf \u03c3\u03c5\u03c7\u03bd\u03ac \u03c3\u03b5 \u03bc\u03b7\u03c4\u03ad\u03c1\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03b1\u03b9\u03b4\u03b9\u03ac \u03b8\u03b5\u03c4\u03b9\u03ba\u03ac \u03b3\u03b9\u03b1 \u03bc\u03b9\u03ba\u03c1\u03bf\u03c7\u03b9\u03bc\u03b1\u03b9\u03c1\u03b9\u03c3\u03bc\u03cc. \u0395\u03be\u03ac\u03bb\u03bb\u03bf\u03c5 \u03c3\u03b5 \u03c0\u03b5\u03b9\u03c1\u03b1\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03bc\u03bf\u03bd\u03c4\u03ad\u03bb\u03b1 \u03c0\u03bf\u03bd\u03c4\u03b9\u03ba\u03ce\u03bd \u03bc\u03b5 \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03b7 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03af\u03c4\u03b9\u03b4\u03b1 (\u0395\u0391\u03a4), \u03b5\u03bc\u03b2\u03c1\u03c5\u03b9\u03ba\u03ac \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 (\u03a4 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03ba\u03b1\u03b9 \u03b4\u03b5\u03bd\u03b4\u03c1\u03b9\u03c4\u03b9\u03ba\u03ac) \u03b2\u03c1\u03ad\u03b8\u03b7\u03ba\u03b1\u03bd \u03bd\u03b1 \u03c3\u03c5\u03c3\u03c3\u03c9\u03c1\u03b5\u03cd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b5\u03af\u03c2 \u03c4\u03c9\u03bd \u03bc\u03b7\u03c4\u03ad\u03c1\u03c9\u03bd. \u03a9\u03c3\u03c4\u03cc\u03c3\u03bf \u03c0\u03b1\u03c1\u03ac \u03c4\u03b9\u03c2 \u03b1\u03bd\u03c9\u03c4\u03ad\u03c1\u03c9 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03ae\u03c3\u03b5\u03b9\u03c2 \u03bc\u03cc\u03bd\u03bf \u03bc\u03af\u03b1 case-control \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03b1\u03bd\u03b1\u03b3\u03bd\u03ce\u03c1\u03b9\u03c3\u03b5 \u03c4\u03b7 \u03bc\u03b7\u03c4\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1 (parity) \u03c9\u03c2 \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u03b3\u03b9\u03b1 \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7 \u0398\u0391 (124) \u03b5\u03bd\u03ce \u03ac\u03bb\u03bb\u03b5\u03c2 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b5\u03c2 \u03b5\u03c0\u03b9\u03b4\u03b7\u03bc\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03b4\u03b5 \u03b2\u03c1\u03ae\u03ba\u03b1\u03bd \u03c3\u03c5\u03c3\u03c7\u03ad\u03c4\u03b9\u03c3\u03b7 \u03ba\u03ac\u03c4\u03b9 \u03c0\u03bf\u03c5 \u03c5\u03c0\u03bf\u03b4\u03b7\u03bb\u03ce\u03bd\u03b5\u03b9 \u03c0\u03c9\u03c2 \u03bf \u03bc\u03b9\u03ba\u03c1\u03bf\u03c7\u03b9\u03bc\u03b1\u03b9\u03c1\u03b9\u03c3\u03bc\u03cc\u03c2 \u03af\u03c3\u03c9\u03c2 \u03ad\u03c7\u03b5\u03b9 \u03bf\u03c1\u03b9\u03b1\u03ba\u03ae \u03c3\u03c5\u03bd\u03b5\u03b9\u03c3\u03c6\u03bf\u03c1\u03ac \u03c3\u03c4\u03b7\u03bd \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 \u0398\u0391 (125,126).
            \n<\/b><\/p>\n

            3.6. \u0391\u03b9\u03c4\u03b9\u03bf\u03c0\u03b1\u03b8\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1 <\/b>IgG<\/b>4 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03af\u03c4\u03b9\u03b4\u03b1\u03c2 <\/b><\/h5>\n

            \u039f\u03b9 \u03c0\u03b1\u03b8\u03bf\u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03bf\u03af \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03af \u03c0\u03bf\u03c5 \u03bf\u03b4\u03b7\u03b3\u03bf\u03cd\u03bd \u03c3\u03c4\u03b7\u03bd <\/b>IgG4 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03af\u03c4\u03b9\u03b4\u03b1 \u03b4\u03b5\u03bd \u03ad\u03c7\u03bf\u03c5\u03bd \u03b1\u03ba\u03cc\u03bc\u03b1 \u03b1\u03c0\u03bf\u03c3\u03b1\u03c6\u03b7\u03bd\u03b9\u03c3\u03c4\u03b5\u03af. \u03a3\u03b5 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u0399gG4-\u03c3\u03c7\u03b5\u03c4\u03b9\u03b6\u03cc\u03bc\u03b5\u03bd\u03b5\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5\u03c2 \u03ad\u03c7\u03b5\u03b9 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b7\u03b8\u03b5\u03af \u03b5\u03c0\u03b9\u03ba\u03c1\u03ac\u03c4\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 Th2 \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae\u03c2 \u03b1\u03c0\u03ac\u03bd\u03c4\u03b7\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae Th2 \u03ba\u03c5\u03c4\u03bf\u03ba\u03b9\u03bd\u03ce\u03bd \u03cc\u03c0\u03c9\u03c2 \u03bf\u03b9 IL-4, IL-5, IL-10, IL-13. \u0395\u03c0\u03af\u03c3\u03b7\u03c2 \u03bf \u03b1\u03c1\u03b9\u03b8\u03bc\u03cc\u03c2 \u03c4\u03c9\u03bd \u03a4regs \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf\u03c2 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03c0\u03c1\u03bf\u03c3\u03b2\u03b5\u03b2\u03bb\u03b7\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2 \u03b9\u03c3\u03c4\u03bf\u03cd\u03c2 \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03c4\u03bf \u03c0\u03b5\u03c1\u03b9\u03c6\u03b5\u03c1\u03b9\u03ba\u03cc \u03b1\u03af\u03bc\u03b1 \u03c4\u03c9\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd. \u0397 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae IL-10 \u03b1\u03c0\u03cc \u03c4\u03b1 Tregs \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03a4h2 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03af\u03c3\u03c9\u03c2 \u03b5\u03c5\u03bf\u03b4\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae IgG-4 \u03b1\u03c0\u03cc \u03c4\u03b1 \u0392 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b5\u03bd\u03ce \u03b7 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae TGF-\u03b2, \u03c0\u03bf\u03c5 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b5\u03af\u03c4\u03b1\u03b9, \u03b5\u03c0\u03ac\u03b3\u03b5\u03b9 \u03c4\u03b7 \u03b4\u03b7\u03bc\u03b9\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03b9\u03bd\u03ce\u03b4\u03bf\u03c5\u03c2 \u03b9\u03c3\u03c4\u03bf\u03cd.<\/p>\n

            4. \u039f \u03c1\u03cc\u03bb\u03bf\u03c2 \u03c4\u03c9\u03bd \u03c5\u03c0\u03bf\u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03b9\u03ce\u03bd \u03c4\u03c9\u03bd \u03a4\u03b1 \u03ba\u03b1\u03b9 \u0392 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c3\u03c4\u03b7 \u0398\u0391 <\/b><\/h4>\n
            \u00a04.1. \u03a4<\/b>regs<\/b> \u03c3\u03c4\u03b7 \u0398\u0391<\/b><\/h5>\n

            \u03a0\u03b5\u03b9\u03c1\u03ac\u03bc\u03b1\u03c4\u03b1 \u03c3\u03b5 \u03c0\u03bf\u03bd\u03c4\u03af\u03ba\u03b9\u03b1 \u03b1\u03bd\u03b8\u03b5\u03ba\u03c4\u03b9\u03ba\u03ac \u03c3\u03b5 \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03b7\u03c2 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03af\u03c4\u03b9\u03b4\u03b1\u03c2 (B cell deficient NOD.H-2h4 mice) \u03ad\u03b4\u03b5\u03b9\u03be\u03b1\u03bd \u03c0\u03c9\u03c2 \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u03c0\u03b1\u03c1\u03bf\u03b4\u03b9\u03ba\u03ae \u03b5\u03be\u03ac\u03bb\u03b5\u03b9\u03c8\u03b7 \u03c4\u03c9\u03bd Tregs \u03bc\u03b5 \u03c4\u03b7 \u03c7\u03c1\u03ae\u03c3\u03b7 anti-CD25, \u03b1\u03c5\u03c4\u03ac \u03b1\u03bd\u03ad\u03c0\u03c4\u03c5\u03be\u03b1\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03af\u03c4\u03b9\u03b4\u03b1 (127). \u0395\u03c0\u03af\u03c3\u03b7\u03c2, \u03b7 \u03b5\u03be\u03ac\u03bb\u03b5\u03b9\u03c8\u03b7 \u03c4\u03c9\u03bd Tregs \u03b5\u03af\u03c7\u03b5 \u03c9\u03c2 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03bf 30% \u03c4\u03c9\u03bd C57BL\/6 \u03c0\u03bf\u03bd\u03c4\u03b9\u03ba\u03ce\u03bd \u03c0\u03bf\u03c5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03bd\u03b8\u03b5\u03ba\u03c4\u03b9\u03ba\u03ac \u03c3\u03b5 \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 GD \u03bd\u03b1 \u03b3\u03af\u03bd\u03bf\u03c5\u03bd \u03b5\u03c5\u03b1\u03af\u03c3\u03b8\u03b7\u03c4\u03b1 \u03c3\u03b5 \u03b5\u03c0\u03b1\u03b3\u03c9\u03b3\u03ae \u03c5\u03c0\u03b5\u03c1\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03c3\u03bc\u03bf\u03cd \u03b5\u03bd\u03ce \u03bf \u03c7\u03b5\u03b9\u03c1\u03b9\u03c3\u03bc\u03cc\u03c2 \u03b1\u03c5\u03c4\u03cc\u03c2 \u03b1\u03cd\u03be\u03b7\u03c3\u03b5 \u03c4\u03b7 \u03c3\u03bf\u03b2\u03b1\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03c3\u03b5 BALB\/c \u03c0\u03bf\u03bd\u03c4\u03af\u03ba\u03b9\u03b1 \u03c0\u03bf\u03c5 \u03ae\u03c4\u03b1\u03bd \u03b5\u03c5\u03b1\u03af\u03c3\u03b8\u03b7\u03c4\u03b1 \u03c3\u03c4\u03b7\u03bd \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 \u03c5\u03c0\u03b5\u03c1\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03c3\u03bc\u03bf\u03cd (128). \u039f\u03b9 \u039corris \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bd. \u03ad\u03b4\u03b5\u03b9\u03be\u03b1\u03bd \u03c0\u03c9\u03c2 \u03c4\u03b1 Tregs \u03bc\u03b5\u03c4\u03b1\u03b2\u03ac\u03bb\u03bb\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03c1\u03c1\u03ad\u03c0\u03b5\u03b9\u03b1 \u03c3\u03b5 \u03c0\u03b5\u03b9\u03c1\u03b1\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03b7 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03af\u03c4\u03b9\u03b4\u03b1 \u03c4\u03cc\u03c3\u03bf \u03c3\u03b5 na\u00efve \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c4\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b1 \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03c4\u03b7\u03c2 Tg (mTgtolerized) \u03c0\u03bf\u03bd\u03c4\u03af\u03ba\u03b9\u03b1 (129). \u0397 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b1\u03c5\u03be\u03b7\u03c4\u03b9\u03ba\u03bf\u03cd \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1 GM-CSF \u03c0\u03c1\u03bf\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03b9 \u03ba\u03b1\u03b9 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c0\u03b5\u03b9\u03c1\u03b1\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03b7 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03af\u03c4\u03b9\u03b4\u03b1 \u03c3\u03c4\u03b1 \u03c0\u03bf\u03bd\u03c4\u03af\u03ba\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bd\u03bf\u03b4\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd CD4+CD25+ Tregs (130). \u0397 \u03b5\u03c0\u03b1\u03b3\u03c9\u03b3\u03ae \u03c4\u03c9\u03bd \u03b4\u03b5\u03bd\u03b4\u03c1\u03b9\u03c4\u03b9\u03ba\u03ce\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03bc\u03b5 \u03c4\u03b7 \u03c7\u03c1\u03ae\u03c3\u03b7 GM-CSF \u03af\u03c3\u03c9\u03c2 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03c4\u03b7\u03c2 \u03b8\u03c5\u03c1\u03b5\u03bf\u03c3\u03c6\u03b1\u03b9\u03c1\u03af\u03bd\u03b7\u03c2 CD4+CD25+ Tregs \u03ba\u03b1\u03b9 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03b7 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03af\u03c4\u03b9\u03b4\u03b1. \u03a4\u03b1 \u03c0\u03bf\u03bd\u03c4\u03af\u03ba\u03b9\u03b1 \u03c3\u03c4\u03b1 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c7\u03bf\u03c1\u03b7\u03b3\u03ae\u03b8\u03b7\u03ba\u03b5 GM-CSF \u03b5\u03af\u03c7\u03b1\u03bd \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc CD4+CD25+ Tregs \u03b5\u03bd\u03ce \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03c0\u03bf\u03bd\u03c4\u03af\u03ba\u03b9\u03b1 \u03b1\u03c5\u03c4\u03ac \u03c0\u03b1\u03c1\u03ae\u03b3\u03b1\u03b3\u03b1\u03bd \u03bc\u03b5\u03b3\u03ac\u03bb\u03b5\u03c2 \u03c0\u03bf\u03c3\u03cc\u03c4\u03b7\u03c4\u03b5\u03c2 IL-10. \u0386\u03c1\u03b1 \u03b7 \u03c3\u03c4\u03c1\u03bf\u03c6\u03ae \u03c4\u03b7\u03c2 \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae\u03c2 \u03b1\u03c0\u03ac\u03bd\u03c4\u03b7\u03c3\u03b7\u03c2 \u03c0\u03c1\u03bf\u03c2 Th2 \u03b1\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7 (\u03bc\u03b5 \u03c4\u03b7 \u03c7\u03c1\u03ae\u03c3\u03b7 \u03b5\u03ba\u03bb\u03b5\u03ba\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd \u03b4\u03b5\u03bd\u03b4\u03c1\u03b9\u03c4\u03b9\u03ba\u03ce\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03bc\u03b5 GM-CSF) \u03af\u03c3\u03c9\u03c2 \u03ad\u03c7\u03b5\u03b9 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03b5\u03c6\u03b1\u03c1\u03bc\u03bf\u03b3\u03ae \u03c3\u03b5 \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03b5\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5\u03c2 \u03cc\u03c0\u03bf\u03c5 \u03ba\u03c5\u03c1\u03b9\u03b1\u03c1\u03c7\u03b5\u03af \u03b7 Th1 \u03b1\u03c0\u03ac\u03bd\u03c4\u03b7\u03c3\u03b7, \u03cc\u03c0\u03c9\u03c2 \u03b7 \u0397\u03a4 (131).<\/p>\n

            \u039f\u03b9 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03b1\u03c6\u03bf\u03c1\u03bf\u03cd\u03bd \u03c3\u03c4\u03bf \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03c4\u03c9\u03bd Tregs \u03c3\u03c4\u03bf \u03c0\u03b5\u03c1\u03b9\u03c6\u03b5\u03c1\u03b9\u03ba\u03cc \u03b1\u03af\u03bc\u03b1 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03bc\u03b5 \u0398\u0391 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b1\u03bd\u03c4\u03b9\u03ba\u03c1\u03bf\u03c5\u03cc\u03bc\u03b5\u03bd\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1. \u0397 \u03ad\u03bb\u03bb\u03b5\u03b9\u03c8\u03b7 \u03bf\u03bc\u03bf\u03c6\u03c9\u03bd\u03af\u03b1\u03c2 \u03af\u03c3\u03c9\u03c2 \u03bf\u03c6\u03b5\u03af\u03bb\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03cc \u03c4\u03c1\u03cc\u03c0\u03bf \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03bc\u03bf\u03cd \u03c4\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03b1\u03c5\u03c4\u03ce\u03bd \u03c3\u03c4\u03b9\u03c2 \u03c0\u03b1\u03bb\u03b1\u03b9\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2, \u03c3\u03c4\u03bf \u03bc\u03b9\u03ba\u03c1\u03cc \u03b1\u03c1\u03b9\u03b8\u03bc\u03cc \u03c4\u03c9\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd, \u03c4\u03b9\u03c2 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c5\u03c0\u03bf\u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b5\u03c2 Tregs \u03c0\u03bf\u03c5 \u03bc\u03b5\u03c4\u03c1\u03ce\u03bd\u03c4\u03b1\u03b9 \u03ae \u03c3\u03c4\u03bf \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03cc \u03b1\u03c1\u03b9\u03b8\u03bc\u03cc \u03c4\u03c9\u03bd Tregs \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03bf \u03c3\u03c4\u03ac\u03b4\u03b9\u03bf \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5. \u0388\u03c4\u03c3\u03b9, \u03ba\u03ac\u03c0\u03bf\u03b9\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03b4\u03b5 \u03b2\u03c1\u03af\u03c3\u03ba\u03bf\u03c5\u03bd \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03ac \u03c3\u03c4\u03bf\u03bd \u03b1\u03c1\u03b9\u03b8\u03bc\u03cc \u03c4\u03c9\u03bd Tregs \u03c3\u03c4\u03b7 \u0398\u0391 \u03b5\u03bd\u03ce \u03ac\u03bb\u03bb\u03b5\u03c2 \u03b1\u03bd\u03b1\u03c6\u03ad\u03c1\u03bf\u03c5\u03bd \u03bc\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03b1 \u03ae \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1, \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03c3\u03c7\u03ad\u03c4\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b1 TS\u0391b \u03c3\u03c4\u03b7 GD \u03ba\u03b1\u03b9 \u03b5\u03c0\u03b9\u03c3\u03c4\u03c1\u03bf\u03c6\u03ae \u03c3\u03c4\u03bf \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03bc\u03b5\u03c4\u03ac \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c4\u03b7\u03c2 HT (64,132-135). \u03a6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c0\u03ac\u03bd\u03c4\u03c9\u03c2 \u03c0\u03c9\u03c2 \u03c4\u03b1 \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03bf\u03cd\u03bd\u03c4\u03b1 Tregs \u03b5\u03af\u03bd\u03b1\u03b9 \u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03ac \u03ba\u03b1\u03b9 \u03bb\u03b9\u03b3\u03cc\u03c4\u03b5\u03c1\u03bf \u03b9\u03ba\u03b1\u03bd\u03ac \u03bd\u03b1 \u03b1\u03bd\u03b1\u03c3\u03c4\u03b5\u03af\u03bb\u03bf\u03c5\u03bd \u03c4\u03bf\u03bd \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03cc \u03c4\u03c9\u03bd \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ce\u03bd \u03a4 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c4\u03c9\u03bd (T effectors) <\/b>(134). \u03a3\u03c4\u03b7\u03bd \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 GD \u03b7 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b9\u03ba\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03b1\u03c5\u03c4\u03ae\u03c2 \u03af\u03c3\u03c9\u03c2 \u03bf\u03c6\u03b5\u03af\u03bb\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae IFN-a \u03b1\u03c0\u03cc \u03b4\u03b5\u03bd\u03b4\u03c1\u03b9\u03c4\u03b9\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03b5\u03c0\u03ac\u03b3\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b1\u03c0\u03cc\u03c0\u03c4\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd Tregs (136). \u0397 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae\u03c2 \u03c4\u03b7\u03c2 IFN-a \u03b1\u03c0\u03bf\u03ba\u03b1\u03c4\u03ad\u03c3\u03c4\u03b7\u03c3\u03b5 \u03c4\u03b7 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03c4\u03c9\u03bd Tregs \u03ba\u03b1\u03b9 \u03bc\u03b5\u03af\u03c9\u03c3\u03b5 \u03c4\u03b1 Th2 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 GD (136) \u03b5\u03bd\u03ce \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03bf\u03b9\u03c7\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b5\u03af\u03c7\u03b5 \u03ba\u03b1\u03b9 \u03b7 \u03b5\u03bd\u03b4\u03bf\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae \u03ad\u03bd\u03b5\u03c3\u03b7 \u03b4\u03b5\u03be\u03b1\u03bc\u03b5\u03b8\u03b1\u03b6\u03cc\u03bd\u03b7\u03c2 (137).<\/p>\n

            \u03a4\u03b1 \u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03ac \u03a4regs \u03af\u03c3\u03c9\u03c2 \u03b5\u03c5\u03bf\u03b4\u03ce\u03bd\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03b1\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1 \u03b1\u03bd\u03bf\u03c7\u03ae\u03c2 \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03c4\u03c9\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b5\u03c0\u03b1\u03ba\u03cc\u03bb\u03bf\u03c5\u03b8\u03b7 \u03b1\u03bd\u03ac\u03b4\u03b5\u03b9\u03be\u03b7 anti-TSHR \u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd. \u0397 \u03b2\u03b5\u03bb\u03c4\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 GD \u03c3\u03c4\u03b7\u03bd \u03ba\u03cd\u03b7\u03c3\u03b7 \u03af\u03c3\u03c9\u03c2 \u03bf\u03c6\u03b5\u03af\u03bb\u03b5\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03c5\u03c0\u03b5\u03c1\u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae Tregs. \u03a0\u03c9\u03c2 \u03cc\u03bc\u03c9\u03c2 \u03c0\u03b1\u03c1\u03b1\u03ba\u03ac\u03bc\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03b4\u03c1\u03ac\u03c3\u03b7 \u03c4\u03c9\u03bd Tregs \u03c3\u03c4\u03b7\u03bd \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u0398\u0391; \u03a4\u03b1 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03a4 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03af\u03c3\u03c9\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c6\u03ad\u03c1\u03bd\u03bf\u03c5\u03bd \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03ba\u03ac\u03bc\u03c0\u03c4\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03b1\u03c0\u03cc \u03c4\u03b1 Tregs \u03bc\u03ad\u03c3\u03c9 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03ba\u03b9\u03bd\u03ce\u03bd \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03c5\u03bd \u03b5\u03bd\u03ce \u03ba\u03b1\u03b8\u03ce\u03c2 \u03b7 \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ae \u03bb\u03cd\u03b5\u03c4\u03b1\u03b9, \u03b7 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03b1\u03bb\u03c4\u03b9\u03ba\u03ae \u03b4\u03c1\u03ac\u03c3\u03b7 \u03c4\u03c9\u03bd Tregs \u03b5\u03c0\u03b1\u03bd\u03ad\u03c1\u03c7\u03b5\u03c4\u03b1\u03b9. <\/b>\u039c\u03b5 \u03c4\u03bf \u03c7\u03c1\u03cc\u03bd\u03bf \u03cc\u03bc\u03c9\u03c2 \u03c4\u03b1 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03a4 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03af\u03c3\u03c9\u03c2 \u03b3\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bb\u03b9\u03b3\u03cc\u03c4\u03b5\u03c1\u03bf \u03b5\u03c5\u03b1\u03af\u03c3\u03b8\u03b7\u03c4\u03b1 \u03c3\u03c4\u03b7\u03bd \u03bc\u03ad\u03c3\u03c9 Tregs \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03ae \u03c4\u03b1 Tregs \u03b5\u03be\u03b1\u03bd\u03c4\u03bb\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03ac.<\/p>\n

            4.2.<\/b> Th1, Th2, <\/b>\u03a4<\/b>h<\/b>17<\/b>, Th<\/b>22<\/b>,<\/b> <\/b>Tfh<\/b> (<\/b>follicular<\/b> <\/b>helper<\/b> <\/b>T<\/b> <\/b>cells<\/b>), <\/b>B<\/b> \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c3\u03c4\u03b7 \u0398\u0391<\/b><\/h5>\n
            4.2.1. \u03a4<\/b>h<\/b>1 \u03ba\u03b1\u03b9 \u03a4<\/b>h<\/b>2 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1<\/b><\/h6>\n

            \u03a3\u03c4\u03b7\u03bd \u0397\u03a4 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf\u03c2 \u03bb\u03cc\u03b3\u03bf\u03c2 Th1\/Th2 \u03ba\u03c5\u03c4\u03bf\u03ba\u03b9\u03bd\u03ce\u03bd \u03b5\u03bd\u03ce \u03b8\u03b5\u03c9\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03c0\u03c9\u03c2 \u03c4\u03b1 APC \u03b5\u03ba\u03c6\u03c1\u03ac\u03b6\u03bf\u03c5\u03bd \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 B7.1 \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03bd\u03b1 \u03c0\u03c1\u03bf\u03c3\u03c6\u03ad\u03c1\u03bf\u03c5\u03bd \u03c3\u03c4\u03b1 \u03b4\u03b9\u03b7\u03b8\u03bf\u03cd\u03bd\u03c4\u03b1 \u03c4\u03bf \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03ae \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c3\u03c5\u03bd\u03b4\u03b9\u03b5\u03b3\u03b5\u03c1\u03c4\u03b9\u03ba\u03cc \u03c3\u03ae\u03bc\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 Th1 \u03ba\u03c5\u03c4\u03bf\u03ba\u03b9\u03bd\u03ce\u03bd (IFN-\u03b3, TNF-\u03b1, IL-2) (138). \u0391\u03c5\u03c4\u03cc \u03ad\u03c7\u03b5\u03b9 \u03c9\u03c2 \u03c3\u03c5\u03bd\u03ad\u03c0\u03b5\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03af\u03b1\u03c2 \u03c4\u03c9\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c3\u03b5 \u03b1\u03c0\u03cc\u03c0\u03c4\u03c9\u03c3\u03b7 (139). \u03a4\u03b1 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03ba\u03b1\u03b9 \u03b1\u03c5\u03c4\u03ac \u03bd\u03b1 \u03b5\u03ba\u03c6\u03c1\u03ac\u03b6\u03bf\u03c5\u03bd \u03c4\u03cc\u03c3\u03bf \u03927.1 \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03927.2 \u03bc\u03cc\u03c1\u03b9\u03b1 \u03bc\u03b5 \u03b5\u03c0\u03b1\u03ba\u03cc\u03bb\u03bf\u03c5\u03b8\u03b7 \u03b4\u03b9\u03ad\u03b3\u03b5\u03c1\u03c3\u03b7 \u03c4\u03b7\u03c2 Th1 \u03ae Th2 \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03bf\u03b9\u03c7\u03b1 \u03b1\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2. \u038c\u03c3\u03bf\u03bd \u03cc\u03bc\u03c9\u03c2 \u03b1\u03c6\u03bf\u03c1\u03ac \u03c3\u03c4\u03b7 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b9\u03ba\u03ae \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03927.1 \u03c3\u03c4\u03b7 \u0398\u0391 \u03bf\u03b9 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03bf\u03c5\u03bd \u03b1\u03bd\u03c4\u03b9\u03ba\u03c1\u03bf\u03c5\u03cc\u03bc\u03b5\u03bd\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1. \u0397 \u03b5\u03c0\u03b9\u03ba\u03c1\u03b1\u03c4\u03bf\u03cd\u03c3\u03b1 \u03ac\u03c0\u03bf\u03c8\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03c9\u03c2 \u03c3\u03c4\u03b7 \u0397\u03a4 \u03c4\u03b1 \u03b8\u03c5\u03c1\u03b5\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03bf\u03c5\u03bd \u03b9\u03c3\u03c7\u03c5\u03c1\u03ae \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03927.1 (140). <\/i>\u0397 \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae Th1 \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03c4\u03c9\u03bd Th2 \u03ba\u03c5\u03c4\u03bf\u03ba\u03b9\u03bd\u03ce\u03bd \u03c3\u03c4\u03b7\u03bd \u0397\u03a4 \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c0\u03c9\u03c2 \u03b4\u03b5\u03bd \u03c0\u03b5\u03c1\u03b9\u03bf\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b1 \u03b5\u03bd\u03b4\u03bf\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b1\u03bb\u03bb\u03ac \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03b9 \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03c0\u03b5\u03c1\u03b9\u03c6\u03b5\u03c1\u03b9\u03ba\u03ac CD4 \u03ba\u03b1\u03b9 CD8 T \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 (141). \u0391\u03bd \u03b1\u03c5\u03c4\u03cc \u03b9\u03c3\u03c7\u03cd\u03b5\u03b9, \u03b7 \u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c0\u03bf\u03c5 \u03c6\u03ad\u03c1\u03bf\u03c5\u03bd \u03927.1, \u03bc\u03b5 \u03a4 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c0\u03bf\u03c5 \u03c6\u03ad\u03c1\u03bf\u03c5\u03bd CD28 \u03b8\u03b1 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03c3\u03b5 \u03bd\u03b1 \u03bf\u03b4\u03b7\u03b3\u03ae\u03c3\u03b5\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b1\u03b3\u03c9\u03b3\u03ae \u03c4\u03b7\u03c2 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7\u03c2 \u03a4 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ce\u03bd \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03c4\u03ad\u03c4\u03bf\u03b9\u03b1 \u03c1\u03cd\u03b8\u03bc\u03b9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c0\u03c1\u03bf\u03b1\u03c0\u03bf\u03c0\u03c4\u03c9\u03c4\u03b9\u03ba\u03ce\u03bd \u03ba\u03b1\u03b9 \u03b1\u03bd\u03c4\u03b9\u03b1\u03c0\u03bf\u03c0\u03c4\u03c9\u03c4\u03b9\u03ba\u03ce\u03bd \u03bc\u03bf\u03c1\u03af\u03c9\u03bd \u03c0\u03bf\u03c5 \u03bd\u03b1 \u03b5\u03c5\u03bd\u03bf\u03b5\u03af \u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd.<\/p>\n

            \u03a3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03bf \u03c1\u03cc\u03bb\u03bf\u03c2 \u03c4\u03b7\u03c2 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1\u03c3\u03b7\u03c2 \u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03c9\u03bd \u03b1\u03c0\u03cc \u03c4\u03b1 APC \u03c3\u03c4\u03b1 CD8 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03bc\u03ad\u03c3\u03c9 \u03c4\u03b7\u03c2 \u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 MHC-I \u03bc\u03b5 \u03c4\u03bf\u03bd TCR. \u0395\u03b9\u03b4\u03b9\u03ba\u03cc\u03c4\u03b5\u03c1\u03b1, \u03b7 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03b7\u03c2 \u03b1\u03bd\u03c4\u03b9\u03b3\u03bf\u03bd\u03bf\u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1\u03c3\u03b7\u03c2 \u03b1\u03c5\u03c4\u03ae\u03c2 \u03bc\u03b5 \u03c4\u03b7 \u03c7\u03c1\u03ae\u03c3\u03b7 \u03b5\u03ba\u03bb\u03b5\u03ba\u03c4\u03b9\u03ba\u03bf\u03cd \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03b1 \u03c4\u03bf\u03c5 \u03b1\u03bd\u03bf\u03c3\u03bf\u03c0\u03c1\u03c9\u03c4\u03b5\u03bf\u03c3\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 (\u039f\u039d\u03a70914) \u03c3\u03b5 \u03bc\u03bf\u03bd\u03c4\u03ad\u03bb\u03bf \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03b7\u03c2 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03af\u03c4\u03b9\u03b4\u03b1\u03c2 \u03c0\u03bf\u03bd\u03c4\u03b9\u03ba\u03ce\u03bd NOD-H2, \u03bc\u03b5\u03af\u03c9\u03c3\u03b5 \u03c4\u03b7 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03b4\u03b9\u03ae\u03b8\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03b7 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03a4 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c0\u03c1\u03bf\u03c2 Th1 \u03ba\u03b1\u03b9 Th17 (142). \u0391\u03bd\u03c4\u03af\u03b8\u03b5\u03c4\u03b1 \u03c3\u03b5 \u03c0\u03b5\u03b9\u03c1\u03b1\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc \u03bc\u03bf\u03bd\u03c4\u03ad\u03bb\u03bf \u03c0\u03bf\u03bd\u03c4\u03b9\u03ba\u03ce\u03bd \u03bc\u03b5 GD \u03bf \u03af\u03b4\u03b9\u03bf\u03c2 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03b1\u03c2 \u03b4\u03b5\u03bd \u03b5\u03af\u03c7\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1. \u0391\u03be\u03af\u03b6\u03b5\u03b9 \u03bd\u03b1 \u03b1\u03bd\u03b1\u03c6\u03b5\u03c1\u03b8\u03b5\u03af \u03c0\u03c9\u03c2 \u03bf \u03c1\u03cc\u03bb\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03b1\u03bd\u03bf\u03c3\u03bf\u03c0\u03c1\u03bf\u03c4\u03b5\u03bf\u03c3\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03b1\u03c0\u03bf\u03b4\u03cc\u03bc\u03b7\u03c3\u03b7 \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03ce\u03bd \u03bc\u03ad\u03c3\u03c9 \u03ba\u03b1\u03c3\u03c0\u03b1\u03c3\u03ce\u03bd \u03ba\u03b1\u03b9 \u03b8\u03c1\u03c5\u03c8\u03af\u03bd\u03b7\u03c2. \u03a4\u03b1 APC, \u03ba\u03b1\u03b8\u03ce\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b1 T \u03ba\u03b1\u03b9 B \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b5\u03ba\u03c6\u03c1\u03ac\u03b6\u03bf\u03c5\u03bd \u03bc\u03b9\u03b1 \u03c0\u03b1\u03c1\u03b1\u03bb\u03bb\u03b1\u03b3\u03ae \u03c4\u03bf\u03c5 \u03c0\u03c1\u03c9\u03c4\u03b5\u03bf\u03c3\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c4\u03bf \u03bf\u03c0\u03bf\u03af\u03bf, \u03bc\u03ad\u03c3\u03c9 \u03c4\u03b7\u03c2 \u03b4\u03b9\u03ac\u03c3\u03c0\u03b1\u03c3\u03b7\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03ce\u03bd, \u03c0\u03b1\u03c1\u03ac\u03b3\u03b5\u03b9 \u03bc\u03b5 \u03c0\u03b9\u03bf \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc \u03c4\u03c1\u03cc\u03c0\u03bf \u039cHC-I restricted T cell \u03b5\u03c0\u03b9\u03c4\u03cc\u03c0\u03bf\u03c5\u03c2. \u0391\u03c5\u03c4\u03cc \u03b5\u03af\u03bd\u03b1\u03b9 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03cc\u03c3\u03bf\u03bd \u03b1\u03c6\u03bf\u03c1\u03ac \u03c4\u03b7 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03c4\u03c9\u03bd \u0391PC \u03c3\u03c4\u03b7 \u0397\u03a4 (142).<\/p>\n

            \u0391\u03bd\u03c4\u03af\u03b8\u03b5\u03c4\u03b1 \u03c3\u03c4\u03b7 GD \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 Th2 \u03b1\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7 \u03c9\u03c2 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03b7\u03c2 B7.2 \u03c3\u03c5\u03bd\u03b4\u03b9\u03ad\u03b3\u03b5\u03c1\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 Th2 \u03ba\u03c5\u03c4\u03bf\u03ba\u03b9\u03bd\u03ce\u03bd (IL-4, IL-5, IL-10) (143). \u0391\u03c5\u03c4\u03cc \u03b5\u03c5\u03bd\u03bf\u03b5\u03af \u03c4\u03b7\u03bd \u03b5\u03c0\u03b1\u03ba\u03cc\u03bb\u03bf\u03c5\u03b8\u03b7 \u03b4\u03b9\u03ad\u03b3\u03b5\u03c1\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c7\u03c5\u03bc\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03bf\u03c3\u03af\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03b1\u03c0\u03cc \u03c4\u03b1 \u0392 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1. \u03a6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c0\u03c9\u03c2 \u03c3\u03c4\u03b7 GD, \u03bf\u03b9 Th2 \u03ba\u03c5\u03c4\u03bf\u03ba\u03af\u03bd\u03b5\u03c2 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03bc\u03b5\u03c4\u03b1\u03b2\u03ac\u03bb\u03bb\u03bf\u03c5\u03bd \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 MHC-II \u03b5\u03bd\u03b9\u03c3\u03c7\u03cd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1\u03c3\u03b7 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03c9\u03bd (\u03c0.\u03c7.TSH-R) \u03b1\u03c0\u03cc \u03c4\u03b1 \u03b8\u03c5\u03c1\u03b5\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c3\u03c4\u03b1 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 (2). \u0395\u03c0\u03af\u03c3\u03b7\u03c2 \u03bf \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf\u03c2 \u03bb\u03cc\u03b3\u03bf\u03c2 TNFa\/sCD40L, \u03c0\u03bf\u03c5 \u03b1\u03bd\u03b9\u03c7\u03bd\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 GD, \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b5\u03bd\u03b5\u03c1\u03b3\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03bc\u03b5\u03c4\u03ac\u03b2\u03b1\u03c3\u03b7 \u03b1\u03c0\u03cc Th2 \u03c3\u03b5 \u03a4h1 \u03b1\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7 (144). \u0397 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1 \u03c4\u03b7\u03c2 \u03b9\u03c3\u03bf\u03c1\u03c1\u03bf\u03c0\u03af\u03b1\u03c2 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd Th1 \u03ba\u03b1\u03b9 Th2 \u03b1\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2 \u03c3\u03c4\u03b7 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b9\u03ba\u03ae \u03c6\u03b1\u03b9\u03bd\u03bf\u03c4\u03c5\u03c0\u03b9\u03ba\u03ae \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae\u03c2 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03bf\u03c3\u03af\u03b1\u03c2 \u03b5\u03bd\u03b9\u03c3\u03c7\u03cd\u03b5\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03c4\u03c9\u03bd Coles \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bd. \u03c3\u03c4\u03b7\u03bd \u03bf\u03c0\u03bf\u03af\u03b1 \u03c4\u03bf 1\/3 \u03c4\u03c9\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03bc\u03b5 \u03c3\u03ba\u03bb\u03ae\u03c1\u03c5\u03bd\u03c3\u03b7 \u03ba\u03b1\u03c4\u03ac \u03c0\u03bb\u03ac\u03ba\u03b1\u03c2 \u03b1\u03bd\u03ad\u03c0\u03c4\u03c5\u03be\u03b1\u03bd GD \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 \u03c4\u03bf anti-CD52 \u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03cc \u03b1\u03bd\u03c4\u03af\u03c3\u03c9\u03bc\u03b1 Campath 1-H \u03c0\u03bf\u03c5 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03b5\u03be\u03b1\u03bb\u03b5\u03af\u03c8\u03b5\u03b9 \u03c4\u03b1 \u03a4 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03b5\u03af\u03bb\u03b5\u03b9 \u03c4\u03b7\u03bd \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03b1\u03bd\u03bf\u03c3\u03af\u03b1 (145). \u039c\u03b9\u03b1 \u03c0\u03b9\u03b8\u03b1\u03bd\u03ae \u03b5\u03be\u03ae\u03b3\u03b7\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03b1\u03c5\u03c4\u03cc \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03c9\u03c2 \u03c4\u03b1 \u03a4 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c0\u03bf\u03c5 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7 \u03b4\u03c1\u03ac\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 \u03b5\u03c0\u03ac\u03b3\u03bf\u03c5\u03bd \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c4\u03b7\u03bd Th2 \u03b1\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7 \u03bf\u03b4\u03b7\u03b3\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c3\u03c4\u03b7\u03bd \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 \u03b4\u03b9\u03b5\u03b3\u03b5\u03c1\u03c4\u03b9\u03ba\u03ce\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03ba\u03b1\u03b9 GD. \u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03c4\u03b5\u03bb\u03b5\u03c5\u03c4\u03b1\u03af\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b1\u03bd\u03b1\u03b4\u03b5\u03af\u03be\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03c9\u03bd \u03a4h1 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c3\u03c4\u03b7\u03bd GD \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7\u03bd \u03b1\u03bd\u03b1\u03ba\u03ac\u03bb\u03c5\u03c8\u03b7 \u03c0\u03c9\u03c2 \u03bf \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1\u03c2 \u03c4\u03b7\u03c2 TSH \u03bc\u03c0\u03bf\u03c1\u03b5\u03af, \u03b4\u03c1\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c9\u03c2 \u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03bf, \u03bd\u03b1 \u03c0\u03c5\u03c1\u03bf\u03b4\u03bf\u03c4\u03ae\u03c3\u03b5\u03b9 \u03b5\u03af\u03c4\u03b5 Th1 \u03b5\u03af\u03c4\u03b5 Th2 \u03b1\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7 \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03bf \u03b5\u03af\u03b4\u03bf\u03c2 \u03c4\u03c9\u03bd \u0391PC \u03ba\u03b1\u03b9 \u03c4\u03bf \u03c3\u03c5\u03bd\u03b4\u03b9\u03b5\u03b3\u03b5\u03c1\u03c4\u03b9\u03ba\u03cc \u03c3\u03ae\u03bc\u03b1 \u03c0\u03bf\u03c5 \u03b1\u03c5\u03c4\u03ac \u03c0\u03b1\u03c1\u03ad\u03c7\u03bf\u03c5\u03bd (146).<\/p>\n

            4.2.2. Th<\/b>17\/<\/b>Th<\/b>22 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1<\/b><\/h6>\n

            T\u03b1 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03c9\u03bd \u03a4h17 \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03ad\u03c7\u03bf\u03c5\u03bd \u03b5\u03bc\u03c0\u03bb\u03b1\u03ba\u03b5\u03af \u03c3\u03c4\u03b7\u03bd \u03b1\u03b9\u03c4\u03b9\u03bf\u03c0\u03b1\u03b8\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 HT \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 GD (133,138,147,148). \u0395\u03bd\u03b5\u03c1\u03b3\u03cc \u03c1\u03cc\u03bb\u03bf \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c0\u03c9\u03c2 \u03ad\u03c7\u03b5\u03b9 \u03b7 \u03a4SLP (thymic stromal lymphopoietin), \u03bc\u03b9\u03b1 Th2 \u03ba\u03c5\u03c4\u03bf\u03ba\u03af\u03bd\u03b7 \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03ac\u03b3\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03ba\u03bf\u03ba\u03ba\u03b9\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1. \u03a4\u03b1 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03ac \u03c4\u03b7\u03c2 \u03c0\u03c1\u03bf\u03ac\u03b3\u03bf\u03c5\u03bd \u03c4\u03b7 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd Th17 \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 GD (148). \u0395\u03c0\u03af\u03c3\u03b7\u03c2, \u03b4\u03b5\u03bd\u03b4\u03c1\u03b9\u03c4\u03b9\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1, \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03a4SLP, \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03ae\u03c3\u03bf\u03c5\u03bd \u03c4\u03b1 CD4 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c0\u03c1\u03bf\u03c2 \u03c4\u03b7\u03bd Th2 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03a4h17 \u03ba\u03b1\u03c4\u03b5\u03cd\u03b8\u03c5\u03bd\u03c3\u03b7 \u03bc\u03ad\u03c3\u03c9 \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae\u03c2 IL-23 (149,150). \u03a0\u03bf\u03bb\u03c5\u03bc\u03bf\u03c1\u03c6\u03b9\u03c3\u03bc\u03bf\u03af \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03bf\u03c5 \u03c0\u03bf\u03c5 \u03ba\u03c9\u03b4\u03b9\u03ba\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03c4\u03b7\u03bd TSLP \u03af\u03c3\u03c9\u03c2 \u03b5\u03bc\u03c0\u03bb\u03ad\u03ba\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7 GD (148).<\/p>\n

            \u0388\u03bd\u03b1 \u03ac\u03bb\u03bb\u03bf \u03bc\u03cc\u03c1\u03b9\u03bf \u03c0\u03bf\u03c5 \u03ad\u03c7\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03c1\u03cc\u03bb\u03bf \u03c3\u03c4\u03b7 \u03bc\u03b5\u03c4\u03ac\u03b4\u03bf\u03c3\u03b7 \u03c3\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c4\u03b7\u03c2 IL-17 \u03b5\u03bd\u03ce \u03c4\u03b1\u03c5\u03c4\u03cc\u03c7\u03c1\u03bf\u03bd\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03ba\u03b1\u03b9 \u03bc\u03cc\u03c1\u03b9\u03bf \u03c0\u03c1\u03bf\u03c3\u03ad\u03bb\u03ba\u03c5\u03c3\u03b7\u03c2 (chemoattractant) \u03b3\u03b9\u03b1 \u03c4\u03b1 Th17 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf \u03c0\u03c1\u03bf\u03c3\u03b4\u03ad\u03c4\u03b7\u03c2 \u03c7\u03c5\u03bc\u03bf\u03ba\u03b9\u03bd\u03ce\u03bd CCL20 (chemokine ligand 20). \u039f CCL20 \u03b5\u03ba\u03c6\u03c1\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03bc\u03b1\u03ba\u03c1\u03bf\u03c6\u03ac\u03b3\u03b1 \u03ba\u03b1\u03b9 \u03bb\u03b5\u03c5\u03ba\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03ba\u03b1\u03b9 \u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03b9\u03b4\u03c1\u03ac \u03bc\u03b5 \u03c4\u03bf\u03bd CCR6 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03c0\u03bf\u03c5 \u03b2\u03c1\u03af\u03c3\u03ba\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b1 Th17 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1. \u03a4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c0\u03bb\u03ac\u03c3\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c4\u03bf\u03c5 CCL20 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b1 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 GD \u03ba\u03b1\u03b9 \u03c3\u03c5\u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b8\u03b5\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5 \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03b7\u03c2 \u03bf\u03c3\u03c4\u03b5\u03bf\u03c0\u03bf\u03bd\u03c4\u03af\u03bd\u03b7\u03c2 (\u039fPN) \u03b5\u03bd\u03ce \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b2\u03c1\u03b5\u03b8\u03b5\u03af \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c4\u03c9\u03bd CXCL9 \u03ba\u03b1\u03b9 CXCL11 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03b5\u03bd\u03b5\u03c1\u03b3\u03cc GD (146, 151).<\/p>\n

            H OPN \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03c0\u03c1\u03c9\u03c4\u03b5\u03af\u03bd\u03b7 \u03c4\u03bf\u03c5 \u03b5\u03be\u03c9\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03b9\u03bf\u03c5 \u03c3\u03c4\u03c1\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 (matrix) \u03bc\u03b5 \u03b9\u03b4\u03b9\u03cc\u03c4\u03b7\u03c4\u03b5\u03c2 Th1 \u03ba\u03c5\u03c4\u03bf\u03ba\u03af\u03bd\u03b7\u03c2 \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c0\u03b1\u03c1\u03ac\u03b3\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03b4\u03b5\u03bd\u03b4\u03c1\u03b9\u03c4\u03b9\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03ba\u03b1\u03b9 \u03bc\u03b1\u03ba\u03c1\u03bf\u03c6\u03ac\u03b3\u03b1 (151). \u03a0\u03c1\u03bf\u03ac\u03b3\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae IFN-\u03b3 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03a4 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03ba\u03b1\u03b9 \u03b5\u03c0\u03ac\u03b3\u03b5\u03b9 \u03c4\u03b7\u03bd Th2 \u03b1\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7 (\u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03cc\u03c2 \u0392 \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd, \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd) \u03bc\u03ad\u03c3\u03c9 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7\u03c2 CD40L \u03b1\u03c0\u03cc \u03c4\u03b1 CD4 \u03a4 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03ba\u03b1\u03b9 \u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7\u03c2 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 CD40 \u03c3\u03c4\u03b1 \u0392 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 (152). \u03a4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03b7\u03c2 OPN \u03ad\u03c7\u03bf\u03c5\u03bd \u03b2\u03c1\u03b5\u03b8\u03b5\u03af \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b1 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 GD (153). \u0395\u03c0\u03b9\u03c0\u03c1\u03cc\u03c3\u03b8\u03b5\u03c4\u03b1, \u03b7 \u03c0\u03c1\u03bf\u03c3\u03b8\u03ae\u03ba\u03b7 \u03b1\u03bd\u03b1\u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03ad\u03bd\u03b7\u03c2 OPN \u03ae \u03c0\u03bb\u03ac\u03c3\u03bc\u03b1\u03c4\u03bf\u03c2 \u03b1\u03c0\u03cc \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 GD \u03c3\u03b5 \u03ba\u03b1\u03bb\u03bb\u03b9\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2 CD4 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03b1\u03cd\u03be\u03b7\u03c3\u03b5 \u03c4\u03b7\u03bd \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 CD40L (154), CCL20 \u03ba\u03b1\u03b9 \u0399L-17 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b1\u03c5\u03c4\u03ac \u03b5\u03bd\u03ce \u03b7 \u03c0\u03c1\u03bf\u03c3\u03b8\u03ae\u03ba\u03b7 \u03b1\u03b4\u03c1\u03b1\u03bd\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03bf\u03cd \u03b1\u03bd\u03c4\u03b9-OPN \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c4\u03b7\u03bd \u03b1\u03bd\u03ad\u03c3\u03c4\u03b5\u03b9\u03bb\u03b5. \u0392\u03b1\u03c1\u03cd\u03bd\u03bf\u03c5\u03c3\u03b1\u03c2 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03b7 \u03b1\u03bd\u03b1\u03ba\u03ac\u03bb\u03c5\u03c8\u03b7 \u03c0\u03c9\u03c2 \u03c4\u03b1 \u03b8\u03c5\u03c1\u03b5\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c6\u03ad\u03c1\u03bf\u03c5\u03bd \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03bf\u03cd\u03c2 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03b5\u03af\u03c2 \u0399L-17 \u03ba\u03b1\u03b9 \u03b4\u03cd\u03bd\u03b1\u03bd\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03c5\u03bd \u0399L-6, CXCL10 \u03ba\u03b1\u03b9 ICAM-1 \u03c9\u03c2 \u03b1\u03c0\u03ac\u03bd\u03c4\u03b7\u03c3\u03b7 \u03c3\u03c4\u03b7\u03bd \u0399L-17 \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03ac\u03b3\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03a4h17 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 (155).<\/p>\n

            \u03a0\u03c1\u03cc\u03c3\u03c6\u03b1\u03c4\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b1\u03bd\u03b1\u03b4\u03b5\u03af\u03be\u03b5\u03b9 \u03c4\u03bf \u03c1\u03cc\u03bb\u03bf \u03c4\u03c9\u03bd \u03a4h22 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c3\u03c4\u03b7\u03bd \u03c0\u03b1\u03b8\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1 \u03b1\u03c1\u03ba\u03b5\u03c4\u03ce\u03bd \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03c9\u03bd \u03bd\u03bf\u03c3\u03b7\u03bc\u03ac\u03c4\u03c9\u03bd (29,30). H IL-22, \u03b5\u03af\u03c4\u03b5 \u03c0\u03b1\u03c1\u03ac\u03b3\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03a4h17 \u03b5\u03af\u03c4\u03b5 \u03b1\u03c0\u03cc \u03c4\u03b1 Th22 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03b5\u03bc\u03c0\u03bb\u03ad\u03ba\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03bf\u03c3\u03af\u03b1\u03c2 (156, 157). \u0395\u03b9\u03b4\u03b9\u03ba\u03cc\u03c4\u03b5\u03c1\u03b1, \u03c3\u03b5 IL-22 knockout \u03c0\u03bf\u03bd\u03c4\u03af\u03ba\u03b9\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b7\u03b8\u03b5\u03af \u03b2\u03b5\u03bb\u03c4\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03bf\u03c3\u03af\u03b1\u03c2 \u03b5\u03bd\u03ce \u03b7 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03b7\u03c2 IL-22 \u03bc\u03b5 \u03c4\u03b7 \u03c7\u03c1\u03ae\u03c3\u03b7 \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 \u03b5\u03af\u03c7\u03b5 \u03c4\u03bf \u03af\u03b4\u03b9\u03bf \u03b5\u03c5\u03b5\u03c1\u03b3\u03b5\u03c4\u03b9\u03ba\u03cc \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c3\u03b5 \u03bc\u03bf\u03bd\u03c4\u03ad\u03bb\u03b1 \u03c0\u03bf\u03bd\u03c4\u03b9\u03ba\u03ce\u03bd (158). \u038c\u03c3\u03bf\u03bd \u03b1\u03c6\u03bf\u03c1\u03ac \u03c3\u03c4\u03bf\u03bd \u03ac\u03bd\u03b8\u03c1\u03c9\u03c0\u03bf, \u03b4\u03cd\u03bf \u03bc\u03cc\u03bd\u03bf \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b3\u03af\u03bd\u03b5\u03b9 \u03ad\u03c9\u03c2 \u03c4\u03ce\u03c1\u03b1 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 GD, \u03bf\u03b9 \u03bf\u03c0\u03bf\u03af\u03b5\u03c2 \u03b1\u03bd\u03b1\u03c6\u03ad\u03c1\u03bf\u03c5\u03bd \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b1 \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03ac \u03c0\u03b5\u03c1\u03b9\u03c6\u03b5\u03c1\u03b9\u03ba\u03ce\u03bd Th22 \u03ba\u03b1\u03b9 Th17 \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c3\u03b5 \u03bd\u03b5\u03bf\u03b4\u03b9\u03b5\u03b3\u03bd\u03c9\u03c3\u03b8\u03ad\u03bd\u03c4\u03b5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 GD \u03ba\u03b1\u03b8\u03ce\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c5\u03c3\u03c7\u03ad\u03c4\u03b9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b5\u03c0\u03b9\u03c0\u03ad\u03b4\u03c9\u03bd \u03c4\u03bf\u03c5\u03c2 \u03bc\u03b5 \u03c4\u03b1 \u03b4\u03b9\u03b5\u03b3\u03b5\u03c1\u03c4\u03b9\u03ba\u03ac \u03a4SAb (133,159).<\/p>\n

            4.2.3. T<\/b> <\/b>f<\/b>\u03bf<\/b>llicular<\/b> <\/b>helper<\/b> \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1<\/b><\/h6>\n

            \u0397 \u03c0\u03c1\u03bf\u03c3\u03c6\u03ac\u03c4\u03c9\u03c2 \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03b1\u03c6\u03b5\u03af\u03c3\u03b1 \u03b1\u03c5\u03c4\u03ae \u03c5\u03c0\u03bf\u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b1 \u03a4 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03ad\u03c7\u03b5\u03b9 \u03c3\u03c4\u03b7 \u03c1\u03cd\u03b8\u03bc\u03b9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03bd\u03c4\u03b9\u03b3\u03bf\u03bd\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03bf\u03c3\u03af\u03b1\u03c2 \u03c4\u03c9\u03bd \u0392 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd. \u03a4\u03b1 \u03a4fh \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b2\u03c1\u03b5\u03b8\u03b5\u03af \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b1 \u03c3\u03c4\u03b7 \u0398\u0391 \u03b5\u03bd\u03ce \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03ac \u03c4\u03bf\u03c5\u03c2 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c3\u03c5\u03c3\u03c7\u03b5\u03c4\u03b9\u03c3\u03c4\u03b5\u03af \u03b8\u03b5\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5 \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03c9\u03bd \u03b4\u03b9\u03b5\u03b3\u03b5\u03c1\u03c4\u03b9\u03ba\u03ce\u03bd TSAb, \u03c4\u03c9\u03bd anti-Tg \u03ba\u03b1\u03b9 \u03c4\u03c9\u03bd anti-TPO \u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd. \u03a3\u03b5 \u03bc\u03b9\u03b1 \u03c5\u03c0\u03bf\u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b1 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03bc\u03b5 GD \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03a4fh \u03c5\u03c0\u03bf\u03c7\u03ce\u03c1\u03b7\u03c3\u03b1\u03bd \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c4\u03b7\u03c2 GD. \u038c\u03c3\u03bf\u03bd \u03b1\u03c6\u03bf\u03c1\u03ac \u03c3\u03c4\u03b7\u03bd \u0397\u03a4, \u03ad\u03c7\u03b5\u03b9 \u03b1\u03bd\u03b9\u03c7\u03bd\u03b5\u03c5\u03b8\u03b5\u03af \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 \u03b5\u03bd\u03b4\u03bf\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd Tfh \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd, \u03bc\u03b5 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 IL-21 \u03ba\u03b1\u03b9 Bcl-6, \u03c3\u03b5 \u03b4\u03b5\u03af\u03b3\u03bc\u03b1\u03c4\u03b1 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03bf\u03cd \u03b9\u03c3\u03c4\u03bf\u03cd \u03b1\u03c0\u03cc \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u0397\u03a4 (31,32).<\/p>\n

            4.2.4. \u0392 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1<\/b><\/h6>\n

            \u0399\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b7 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03b4\u03bf\u03b8\u03b5\u03af \u03c3\u03c4\u03bf\u03bd \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc \u03c1\u03cc\u03bb\u03bf \u03c4\u03b7\u03c2 \u03c5\u03c0\u03bf\u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b1\u03c2 \u03c4\u03c9\u03bd B \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03c4\u03b9\u03ba\u03ce\u03bd \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd (\u0392 regulatory cells \u2013Bregs) \u03c3\u03c4\u03b7\u03bd \u03b1\u03b9\u03c4\u03b9\u03bf\u03c0\u03b1\u03b8\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 \u0398\u0391. \u03a4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b1\u03c5\u03c4\u03ac \u03b5\u03ba\u03c6\u03c1\u03ac\u03b6\u03bf\u03c5\u03bd \u03c4\u03b1 \u03bc\u03cc\u03c1\u03b9\u03b1 CD40, FCRL3, CD24hi, CD27 \u03ba\u03b1\u03b9 SCGB3A2 \u03ba\u03b1\u03b9 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03c5\u03bd IL-10. \u03a4\u03b1 \u0392regs \u03ad\u03c7\u03bf\u03c5\u03bd \u03b1\u03bd\u03bf\u03c3\u03bf\u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03b1\u03bb\u03c4\u03b9\u03ba\u03cc \u03c1\u03cc\u03bb\u03bf, \u03cc\u03c0\u03c9\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b1 Tregs, \u03ba\u03b1\u03b9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03c5\u03bd \u03c4\u03bf\u03bd \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03cc \u03c4\u03c9\u03bd CD4 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03a4\u039dF-a, \u0399FN-\u03b3 \u03b1\u03c0\u03cc \u03b1\u03c5\u03c4\u03ac. \u03a4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03ac \u03c4\u03bf\u03c5\u03c2 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b2\u03c1\u03b5\u03b8\u03b5\u03af \u03bc\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03b1 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 GD \u03b5\u03bd\u03ce \u03b1\u03bd\u03b1\u03ba\u03ac\u03bc\u03c0\u03c4\u03bf\u03c5\u03bd \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c4\u03b7\u03c2 GD (160). \u0395\u03ba\u03c4\u03cc\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd \u03b1\u03c1\u03b9\u03b8\u03bc\u03cc \u03c4\u03bf\u03c5\u03c2, \u03bc\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03b2\u03c1\u03ad\u03b8\u03b7\u03ba\u03b5 \u03ba\u03b1\u03b9 \u03b7 \u03b9\u03ba\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03ac \u03c4\u03bf\u03c5\u03c2 \u03bd\u03b1 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03c5\u03bd \u03c4\u03bf\u03bd \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03cc \u03c4\u03c9\u03bd CD4 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 GD (160).<\/p>\n

            \u0388\u03bd\u03b1\u03c2 \u03ac\u03bb\u03bb\u03bf\u03c2 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c0\u03bf\u03c5 \u03b5\u03ba\u03c6\u03c1\u03ac\u03b6\u03bf\u03c5\u03bd \u03c4\u03b1 \u0392 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03ba\u03b1\u03b9 \u03ad\u03c7\u03b5\u03b9 \u03c0\u03c1\u03cc\u03c3\u03c6\u03b1\u03c4\u03b1 \u03b5\u03bc\u03c0\u03bb\u03b1\u03ba\u03b5\u03af \u03c3\u03c4\u03b7\u03bd \u03b1\u03b9\u03c4\u03b9\u03bf\u03c0\u03b1\u03b8\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 \u0398\u0391 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf \u0392\u0391FF (B lymphocyte activating factor), \u03bc\u03b9\u03b1 \u03ba\u03c5\u03c4\u03bf\u03ba\u03af\u03bd\u03b7 \u03c0\u03bf\u03c5 \u03b1\u03bd\u03ae\u03ba\u03b5\u03b9 \u03c3\u03c4\u03b7\u03bd \u03c5\u03c0\u03b5\u03c1-\u03bf\u03b9\u03ba\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1 \u03c4\u03bf\u03c5 TNF \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03ac\u03b3\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03bc\u03b5 \u03c4\u03bf \u03bd\u03b1 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03bf\u03bd \u03b1\u03c1\u03b9\u03b8\u03bc\u03cc \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03c9\u03c1\u03af\u03bc\u03b1\u03bd\u03c3\u03b7 \u03c4\u03c9\u03bd \u0392 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd (161,162). \u0391\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03bf\u03c5 BAFF \u03ad\u03c7\u03bf\u03c5\u03bd \u03b5\u03bd\u03bf\u03c7\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03b5\u03af \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc \u03b5\u03c1\u03c5\u03b8\u03b7\u03bc\u03b1\u03c4\u03ce\u03b4\u03b7 \u03bb\u03cd\u03ba\u03bf, \u03c4\u03b7 \u03c1\u03b5\u03c5\u03bc\u03b1\u03c4\u03bf\u03b5\u03b9\u03b4\u03ae \u03b1\u03c1\u03b8\u03c1\u03af\u03c4\u03b9\u03b4\u03b1 \u03ba\u03b1\u03b9 \u03ac\u03bb\u03bb\u03b1 \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03b1 \u03bd\u03bf\u03c3\u03ae\u03bc\u03b1\u03c4\u03b1. \u038c\u03c3\u03bf\u03bd \u03b1\u03c6\u03bf\u03c1\u03ac \u03c3\u03c4\u03b7 \u0398\u0391, \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03ac \u03c4\u03bf\u03c5 \u03ba\u03b1\u03b8\u03ce\u03c2 \u03ba\u03b1\u03b9 \u03b8\u03b5\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03c3\u03c7\u03ad\u03c4\u03b9\u03c3\u03ae \u03c4\u03bf\u03c5\u03c2 \u03bc\u03b5 \u03c4\u03b1 anti-Tg \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b2\u03c1\u03b5\u03b8\u03b5\u03af \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 GD (161).<\/p>\n

            \u0395\u03c0\u03b9\u03c0\u03c1\u03cc\u03c3\u03b8\u03b5\u03c4\u03b1, \u03c3\u03c4\u03b7\u03bd \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 GD, \u03b7 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u0399COSL \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b4\u03b9\u03b7\u03b8\u03bf\u03cd\u03bd\u03c4\u03b1 \u0392 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03b8\u03c5\u03c1\u03b5\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1, \u03c3\u03b5 \u03b1\u03bd\u03c4\u03af\u03b8\u03b5\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b7\u03bd \u0397\u03a4 \u03cc\u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03bc\u03cc\u03bd\u03bf \u03c3\u03b5 \u0392 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 (162). \u0397 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03ae \u03c4\u03bf\u03c5 \u0399COSL \u03c3\u03c4\u03b1 \u03b8\u03c5\u03c1\u03b5\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b5\u03c0\u03ac\u03b3\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u0399FN-\u03b3, IL-6 \u03ba\u03b1\u03b9 TNF-\u03b1 \u03ba\u03b1\u03b9 \u03b7 \u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03ae \u03c4\u03bf\u03c5 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u0399COS \u03c3\u03c5\u03bd\u03c4\u03b5\u03bb\u03b5\u03af \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03ba\u03c1\u03ac\u03c4\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c0\u03bf\u03c5 \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03af\u03b6\u03b5\u03b9 \u03c4\u03b7\u03bd GD.<\/p>\n

            5. \u0395\u03bd\u03b4\u03bf\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae \u03b5\u03af\u03c3\u03bf\u03b4\u03bf\u03c2 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03ba\u03b1\u03b9 <\/b>APC<\/b> \u03c3\u03c4\u03b7 \u0398\u0391 <\/b><\/h4>\n

            \u03a4\u03cc\u03c3\u03bf \u03c3\u03c4\u03b7\u03bd GD \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd HT \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03b5\u03af\u03c3\u03bf\u03b4\u03bf\u03c2 CD4 \u03ba\u03b1\u03b9 CD8 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c3\u03c4\u03bf \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03cc \u03c0\u03b1\u03c1\u03ad\u03b3\u03c7\u03c5\u03bc\u03b1 \u03bc\u03b5 \u03c0\u03c1\u03bf\u03b5\u03be\u03ac\u03c1\u03c7\u03bf\u03bd\u03c4\u03b1 \u03c4\u03b1 \u03c0\u03c1\u03ce\u03c4\u03b1. \u0397 \u03bc\u03b5\u03c4\u03b1\u03bd\u03ac\u03c3\u03c4\u03b5\u03c5\u03c3\u03b7 \u03c4\u03c9\u03bd \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c3\u03c4\u03bf \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03ae \u03b1\u03b4\u03ad\u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03ce\u03bd \u03bc\u03b7\u03bd\u03c5\u03bc\u03ac\u03c4\u03c9\u03bd \u03c0\u03c1\u03bf\u03c3\u03ad\u03bb\u03ba\u03c5\u03c3\u03ae\u03c2 \u03c4\u03bf\u03c5\u03c2 (163). \u0388\u03c4\u03c3\u03b9 \u03c3\u03c4\u03b7 \u0398\u0391 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03ad\u03ba\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2 \u03ba\u03c5\u03c4\u03bf\u03ba\u03b9\u03bd\u03ce\u03bd \u03cc\u03c0\u03c9\u03c2 \u03bf\u03b9 CCL3, CCL4, CXCL-10, CXCL-19 \u03ba\u03b1\u03b9 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1 RANTES (regulated upon activation, normal T-cell expressed and secreted) \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03c3\u03b5\u03bb\u03ba\u03cd\u03bf\u03c5\u03bd \u03c4\u03b1 \u03a4 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03ba\u03b1\u03b8\u03ce\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03bf\u03b9\u03c7\u03c9\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03c9\u03bd \u03c4\u03bf\u03c5\u03c2 (CXCR3, RANTES receptor) \u03c3\u03c4\u03b1 \u03af\u03b4\u03b9\u03b1 \u03c4\u03b1 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 <\/b>(163,164). \u0391\u03ba\u03cc\u03bc\u03b1 \u03b5\u03c5\u03c1\u03af\u03c3\u03ba\u03b5\u03c4\u03b1\u03b9 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03ba\u03c5\u03c4\u03bf\u03ba\u03b9\u03bd\u03ce\u03bd \u03bc\u03b5 \u03c1\u03cc\u03bb\u03bf \u03c3\u03c4\u03b7\u03bd \u03bf\u03c1\u03b3\u03ac\u03bd\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03bb\u03b5\u03bc\u03c6\u03bf\u03b5\u03b9\u03b4\u03ce\u03bd \u03b8\u03c5\u03bb\u03b1\u03ba\u03af\u03c9\u03bd \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03ac\u03bb\u03bb\u03c9\u03bd \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03c4\u03b1\u03ba\u03c4\u03b9\u03ba\u03ce\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03cc\u03bd\u03c4\u03c9\u03bd \u03c4\u03bf\u03c5 \u03b5\u03bd\u03b4\u03bf\u03b8\u03b7\u03bb\u03af\u03bf\u03c5 \u03cc\u03c0\u03c9\u03c2 \u03c4\u03c9\u03bd \u03c3\u03b5\u03bb\u03b5\u03ba\u03c4\u03b9\u03bd\u03ce\u03bd (CLAA, E \u03ba\u03b1\u03b9 P \u03c3\u03b5\u03bb\u03b5\u03ba\u03c4\u03af\u03bd\u03b5\u03c2) \u03ba\u03b1\u03b9 \u03b9\u03bd\u03c4\u03b5\u03b3\u03ba\u03c1\u03b9\u03bd\u03ce\u03bd (VCAM-1, ICAM-1) \u03bc\u03b5 \u03c4\u03b5\u03bb\u03b9\u03ba\u03cc \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03b7\u03bd \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c0\u03c1\u03bf\u03c3\u03ba\u03cc\u03bb\u03bb\u03b7\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd \u03a4 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c3\u03c4\u03b9\u03c2 \u03b5\u03be\u03c9\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03b9\u03b5\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2 \u03c4\u03bf\u03c5 \u03b5\u03bd\u03b4\u03bf\u03b8\u03b7\u03bb\u03af\u03bf\u03c5 <\/b>(165).<\/p>\n

            \u039c\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c3\u03b5 \u03bc\u03bf\u03bd\u03c4\u03ad\u03bb\u03b1 \u03c0\u03b5\u03b9\u03c1\u03b1\u03bc\u03b1\u03c4\u03cc\u03b6\u03c9\u03c9\u03bd \u03c0\u03bf\u03c5 \u03b1\u03bd\u03b1\u03c0\u03c4\u03cd\u03c3\u03c3\u03bf\u03c5\u03bd \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03b7 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03af\u03c4\u03b9\u03b4\u03b1 \u03b4\u03b5\u03af\u03c7\u03bd\u03bf\u03c5\u03bd \u03c0\u03c9\u03c2 \u03c3\u03b5 \u03c0\u03c1\u03ce\u03c4\u03bf \u03c3\u03c4\u03ac\u03b4\u03b9\u03bf \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03bc\u03b5\u03c4\u03b1\u03bd\u03ac\u03c3\u03c4\u03b5\u03c5\u03c3\u03b7 APC \u03c3\u03c4\u03bf \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03ae \u03b1\u03b4\u03ad\u03bd\u03b1 \u03ba\u03b1\u03b9 \u03b4\u03b9\u03ae\u03b8\u03b7\u03c3\u03ae \u03c4\u03bf\u03c5 (166). \u03a4\u03b1 \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ce\u03b4\u03b7 \u03bc\u03b7\u03bd\u03cd\u03bc\u03b1\u03c4\u03b1 (\u03ba\u03c5\u03c4\u03bf\u03ba\u03af\u03bd\u03b5\u03c2) \u03c0\u03bf\u03c5 \u03bf\u03b4\u03b7\u03b3\u03bf\u03cd\u03bd \u03c3\u03c4\u03b7 \u03c3\u03c5\u03c3\u03c3\u03ce\u03c1\u03b5\u03c5\u03c3\u03b7 \u03c4\u03c9\u03bd APC \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bf\u03c6\u03b5\u03af\u03bb\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03bd\u03ad\u03ba\u03c1\u03c9\u03c3\u03b7 \u03ae \u03b2\u03bb\u03ac\u03b2\u03b7 \u03c4\u03c9\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c4\u03bf\u03be\u03b9\u03bd\u03ce\u03bd, \u03bc\u03b9\u03ba\u03c1\u03bf\u03b2\u03b9\u03b1\u03ba\u03ce\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03cc\u03bd\u03c4\u03c9\u03bd \u03ae \u03c0\u03b5\u03c1\u03af\u03c3\u03c3\u03b5\u03b9\u03b1\u03c2 \u03b9\u03c9\u03b4\u03af\u03bf\u03c5. \u0395\u03c0\u03af\u03c3\u03b7\u03c2 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ad\u03c2 \u03c4\u03bf\u03c5 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03c3\u03bc\u03bf\u03cd \u03ba\u03b1\u03b9 \u03c4\u03bf\u03c5 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03bf\u03cd \u03bc\u03b9\u03ba\u03c1\u03bf\u03c0\u03b5\u03c1\u03b9\u03b2\u03ac\u03bb\u03bb\u03bf\u03bd\u03c4\u03bf\u03c2 \u03af\u03c3\u03c9\u03c2 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03c1\u03cc\u03bb\u03bf. \u03a9\u03c2 \u03b5\u03c0\u03b1\u03ba\u03cc\u03bb\u03bf\u03c5\u03b8\u03bf \u03c4\u03b7\u03c2 \u03c6\u03ac\u03c3\u03b7\u03c2 \u03b1\u03c5\u03c4\u03ae\u03c2 \u03c4\u03b1 \u03b5\u03b9\u03c3\u03b2\u03ac\u03bb\u03bb\u03bf\u03bd\u03c4\u03b1 \u03c3\u03c4\u03bf \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03ae APC \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03b9\u03ac\u03b6\u03bf\u03c5\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03b1 \u03c3\u03c4\u03b1 \u03a4 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1.<\/p>\n

            6. \u0395\u03bd\u03b4\u03bf\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae \u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03a4<\/b>regs<\/b>–<\/b>APC<\/b>–<\/b>T<\/b> \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd-\u0398\u03c5\u03c1\u03b5\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c3\u03c4\u03b7 \u0398\u0391<\/b><\/h4>\n

            \u03a3\u03c4\u03bf \u03c3\u03c4\u03ac\u03b4\u03b9\u03bf \u03b1\u03c5\u03c4\u03cc \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf \u03c1\u03cc\u03bb\u03bf\u03c2 \u03c4\u03b7\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c6\u03b5\u03c1\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03bf\u03c7\u03ae\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03c1\u03cd\u03b8\u03bc\u03b9\u03c3\u03ae\u03c2 \u03c4\u03b7\u03c2 \u03b1\u03c0\u03cc \u03c3\u03c5\u03bd-\u03b4\u03b9\u03b5\u03b3\u03b5\u03c1\u03c4\u03b9\u03ba\u03ac \u03bc\u03cc\u03c1\u03b9\u03b1, \u03bc\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03b1\u03bd \u03b1\u03c5\u03c4\u03ae \u03c0\u03b1\u03c1\u03b1\u03ba\u03b1\u03bc\u03c6\u03b8\u03b5\u03af \u03b1\u03bd\u03bf\u03af\u03b3\u03b5\u03b9 \u03bf \u03b4\u03c1\u03cc\u03bc\u03bf\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ce\u03bd \u03a4 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd. H \u03b4\u03b9\u03b1\u03c4\u03ac\u03c1\u03b1\u03be\u03b7 \u03c4\u03b7\u03c2 \u03b9\u03c3\u03bf\u03c1\u03c1\u03bf\u03c0\u03af\u03b1\u03c2 \u03c4\u03c9\u03bd \u03c0\u03c1\u03bf\u03c3\u03c4\u03b1\u03c4\u03b5\u03c5\u03c4\u03b9\u03ba\u03ce\u03bd Tregs \u03bc\u03b5 \u03c4\u03b1 \u03b5\u03bd\u03b4\u03bf\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b1 APC \u03c0\u03bf\u03c5 \u03c3\u03c5\u03bd\u03c4\u03b5\u03bb\u03bf\u03cd\u03bd \u03c3\u03c4\u03b7 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c0\u03c1\u03bf\u03c2 \u03c4\u03b7\u03bd Th1 \u03ae \u03a4h2 \u03ba\u03b1\u03c4\u03b5\u03cd\u03b8\u03c5\u03bd\u03c3\u03b7, \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03c4\u03b7\u03bd \u03c0\u03b5\u03c1\u03b1\u03b9\u03c4\u03ad\u03c1\u03c9 \u03b5\u03c0\u03b1\u03b3\u03c9\u03b3\u03ae \u03c4\u03b7\u03c2 \u0398\u0391. \u0392\u03b1\u03c3\u03b9\u03ba\u03cc \u03c1\u03cc\u03bb\u03bf \u03c3\u03c4\u03b7\u03bd \u03b9\u03c3\u03bf\u03c1\u03c1\u03bf\u03c0\u03af\u03b1 \u03b1\u03c5\u03c4\u03ae \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c0\u03c9\u03c2 \u03ad\u03c7\u03b5\u03b9 \u03b7 IL-6, \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c9\u03b8\u03b5\u03af \u03c4\u03b7\u03bd \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b1\u03c0\u03ac\u03bd\u03c4\u03b7\u03c3\u03b7 \u03c0\u03c1\u03bf\u03c2 \u03c4\u03b7\u03bd Th17 \u03ae Th1 \u03ba\u03b1\u03c4\u03b5\u03cd\u03b8\u03c5\u03bd\u03c3\u03b7 \u03c0\u03b1\u03c1\u03ac \u03c0\u03c1\u03bf\u03c2 \u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03ba\u03c1\u03ac\u03c4\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b4\u03c1\u03ac\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd Tregs (167). <\/b>H \u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03c4\u03c9\u03bd Tregs, \u03bb\u03cc\u03b3\u03c9 \u03ba\u03c5\u03c4\u03bf\u03ba\u03b9\u03bd\u03ce\u03bd \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b1 APC \u03b5\u03af\u03c4\u03b5 \u03c4\u03b1 \u03af\u03b4\u03b9\u03b1 \u03c4\u03b1 \u03a4 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1, \u03ad\u03c7\u03b5\u03b9 \u03c9\u03c2 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03b7\u03bd \u03b1\u03c0\u03bf\u03b4\u03c5\u03bd\u03ac\u03bc\u03c9\u03c3\u03b7 \u03ae \u03b5\u03be\u03ac\u03bb\u03b5\u03b9\u03c8\u03b7 \u03c4\u03b7\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03b1\u03bb\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03b4\u03c1\u03ac\u03c3\u03b7\u03c2 \u03cc\u03c3\u03bf\u03bd \u03b1\u03c6\u03bf\u03c1\u03ac \u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ce\u03bd \u03a4 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd. \u03a4\u03b1 \u03a4 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c4\u03b1 \u03bf\u03c0\u03bf\u03af\u03b1 \u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03b9\u03b4\u03c1\u03bf\u03cd\u03bd \u03bc\u03b5 \u03c4\u03b1 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03b1 \u03c0\u03bf\u03c5 \u03c4\u03bf\u03c5\u03c2 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03b9\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b1 APC \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03c3\u03c4\u03b7 \u03c3\u03c5\u03bd\u03ad\u03c7\u03b5\u03b9\u03b1 \u03bd\u03b1 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03ae\u03c3\u03bf\u03c5\u03bd \u03b5\u03bb\u03b5\u03cd\u03b8\u03b5\u03c1\u03b1 \u03c4\u03b7\u03bd \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03ae\/\u03ba\u03b1\u03b9 \u03c7\u03c5\u03bc\u03b9\u03ba\u03ae \u03b1\u03bd\u03bf\u03c3\u03af\u03b1. \u03a4\u03b1 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03ba\u03b1\u03b9 \u03b1\u03c5\u03c4\u03ac, \u03bb\u03cc\u03b3\u03c9 \u03c4\u03b7\u03c2 \u03b4\u03c1\u03ac\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03c0\u03b1\u03c1\u03b1\u03b3\u03cc\u03bc\u03b5\u03bd\u03b7\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03a4 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 IFN-\u03b3, \u03bd\u03b1 \u03b5\u03ba\u03c6\u03c1\u03ac\u03c3\u03bf\u03c5\u03bd MHC \u03bc\u03cc\u03c1\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03b4\u03c1\u03ac\u03c3\u03bf\u03c5\u03bd \u03ad\u03c4\u03c3\u03b9 \u03c9\u03c2 APC (168). \u038c\u03c3\u03bf\u03bd \u03b1\u03c6\u03bf\u03c1\u03ac \u03c4\u03b7\u03bd \u03b9\u03ba\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03c9\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03bd\u03b1 \u03b5\u03ba\u03c6\u03c1\u03ac\u03b6\u03bf\u03c5\u03bd \u03927.1 \u03ae \u03927.2 \u03bc\u03cc\u03c1\u03b9\u03b1 \u03bf\u03b9 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03bf\u03c5\u03bd \u03b1\u03bd\u03c4\u03b9\u03ba\u03c1\u03bf\u03c5\u03cc\u03bc\u03b5\u03bd\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1. \u03a0\u03ac\u03bd\u03c4\u03c9\u03c2 \u03bf\u03b9 Battifora \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bd. <\/i>(140) \u03b1\u03bd\u03b1\u03ba\u03ac\u03bb\u03c5\u03c8\u03b1\u03bd \u03b9\u03c3\u03c7\u03c5\u03c1\u03ae \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03927.1 \u03c3\u03c4\u03b1 \u03b8\u03c5\u03c1\u03b5\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03bc\u03b5 \u0397\u03a4. \u0391\u03bd \u03b1\u03c5\u03c4\u03cc \u03b9\u03c3\u03c7\u03cd\u03b5\u03b9, \u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c0\u03bf\u03c5 \u03c6\u03ad\u03c1\u03bf\u03c5\u03bd \u03927.1 \u03bc\u03b5 \u03a4 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c0\u03bf\u03c5 \u03c6\u03ad\u03c1\u03bf\u03c5\u03bd CD28, \u03b8\u03b1 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03c3\u03b5 \u03bd\u03b1 \u03bf\u03b4\u03b7\u03b3\u03ae\u03c3\u03b5\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b1\u03b3\u03c9\u03b3\u03ae \u03c4\u03b7\u03c2 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7\u03c2 \u03a4 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ce\u03bd \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd. \u039f \u03c1\u03cc\u03bb\u03bf\u03c2 \u03c4\u03bf\u03c5 sCTLA-4 \u03b4\u03b5\u03bd \u03ad\u03c7\u03b5\u03b9 \u03b1\u03ba\u03cc\u03bc\u03b1 \u03b4\u03b9\u03b5\u03c5\u03ba\u03c1\u03b9\u03bd\u03b9\u03c3\u03b8\u03b5\u03af \u03bc\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03b2\u03c1\u03af\u03c3\u03ba\u03bf\u03c5\u03bd \u03c4\u03bf \u03bc\u03cc\u03c1\u03b9\u03bf \u03b1\u03c5\u03c4\u03cc \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03b5\u03c2 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ad\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5\u03c2 (18), \u03b5\u03bd\u03ce \u03ac\u03bb\u03bb\u03b5\u03c2 \u03bc\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03bf (50).<\/p>\n

            \u03a3\u03c4\u03bf \u03c4\u03b5\u03bb\u03b5\u03c5\u03c4\u03b1\u03af\u03bf \u03c3\u03c4\u03ac\u03b4\u03b9\u03bf, \u03a4 \u03ba\u03b1\u03b9 \u0392 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b4\u03b9\u03b7\u03b8\u03bf\u03cd\u03bd \u03c4\u03bf \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03cc \u03c0\u03b1\u03c1\u03ad\u03b3\u03c7\u03c5\u03bc\u03b1 \u03c4\u03bf \u03bf\u03c0\u03bf\u03af\u03bf \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03c3\u03c3\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5\u00a0 \u201c\u03c0\u03b5\u03b4\u03af\u03bf \u03bc\u03ac\u03c7\u03b7\u03c2\u201d \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03c4\u03c9\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c4\u03c9\u03bd \u03b5\u03b9\u03c3\u03b2\u03b1\u03bb\u03bb\u03cc\u03bd\u03c4\u03c9\u03bd \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd. \u03a4\u03bf \u03b5\u03af\u03b4\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03bf\u03c5 \u03c0\u03bf\u03c5 \u03b8\u03b1 \u03c5\u03c0\u03b5\u03c1\u03b9\u03c3\u03c7\u03cd\u03c3\u03b5\u03b9 \u03b8\u03b1 \u03ba\u03b1\u03b8\u03bf\u03c1\u03af\u03c3\u03b5\u03b9 \u03c3\u03b5 \u03bc\u03b5\u03b3\u03ac\u03bb\u03bf \u03b2\u03b1\u03b8\u03bc\u03cc \u03c4\u03bf \u03c6\u03b1\u03b9\u03bd\u03cc\u03c4\u03c5\u03c0\u03bf \u03c4\u03b7\u03c2 \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03b7\u03c2 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5. \u039f\u03b9 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03af \u03c0\u03bf\u03c5 \u03b5\u03bc\u03c0\u03bb\u03ad\u03ba\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03c1\u03bf\u03c6\u03ae \u03c4\u03c9\u03bd \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd\/\u03b8\u03c5\u03c1\u03b5\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c3\u03c4\u03b7 \u0398\u0391 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd:<\/p>\n

            6.1. \u039a\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03b1\u03bd\u03bf\u03c3\u03af\u03b1<\/b><\/h5>\n
              \n
            1. \u039a\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b5\u03be\u03b1\u03c1\u03c4\u03ce\u03bc\u03b5\u03bd\u03b7 \u03b1\u03c0\u03cc \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 (antibody dependent cell-mediated cytotoxicity). \u03a4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c4\u03bf\u03c5 \u03b1\u03bd\u03bf\u03c3\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03bf\u03cd \u03c3\u03c5\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2 (\u03c0.\u03c7 \u039d\u039a, \u03bc\u03b1\u03ba\u03c1\u03bf\u03c6\u03ac\u03b3\u03b1, \u03bf\u03c5\u03b4\u03b5\u03c4\u03b5\u03c1\u03cc\u03c6\u03b9\u03bb\u03b1) \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03c1\u03ad\u03c6\u03bf\u03c5\u03bd \u03bc\u03ad\u03c3\u03c9 \u03bb\u03cd\u03c3\u03b7\u03c2 \u03c4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1-\u03c3\u03c4\u03cc\u03c7\u03bf\u03c5\u03c2 (\u03c0.\u03c7 \u03b8\u03c5\u03c1\u03b5\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1) \u03c4\u03b1 \u03bf\u03c0\u03bf\u03af\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b5\u03c0\u03b9\u03c3\u03b7\u03bc\u03b1\u03bd\u03b8\u03b5\u03af \u03bc\u03ad\u03c3\u03c9 \u03c0\u03c1\u03cc\u03c3\u03b4\u03b5\u03c3\u03b7\u03c2 \u03b5\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03c3\u03c4\u03b1 \u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03b1 \u03b5\u03c0\u03b9\u03c6\u03b1\u03bd\u03b5\u03af\u03b1\u03c2 \u03c4\u03bf\u03c5\u03c2.<\/li>\n
            2. \u0391\u03c0\u03cc\u03c0\u03c4\u03c9\u03c3\u03b7 \u03b8\u03c5\u03c1\u03b5\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03ae \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03bc\u03ad\u03c3\u03c9 \u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd Fas\/FasL (suicide\/fratricide) \u03ba\u03b1\u03b9 TRAIL\/TRAIL-R \u03c0\u03bf\u03c5 \u03c6\u03ad\u03c1\u03bf\u03c5\u03bd \u03c3\u03c4\u03b9\u03c2 \u03b5\u03c0\u03b9\u03c6\u03ac\u03bd\u03b5\u03b9\u03ad\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03c9\u03bd \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03bf\u03b9\u03c7\u03c9\u03bd \u03b4\u03b9\u03b1\u03bb\u03c5\u03c4\u03ce\u03bd \u03bc\u03bf\u03c1\u03af\u03c9\u03bd (sFas, sFasL, sTRAIL).<\/li>\n
            3. A\u03bc\u03b5\u03c3\u03b7 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03c4\u03bf\u03be\u03b9\u03ba\u03ae \u03b4\u03c1\u03ac\u03c3\u03b7 (homicide) \u03c4\u03c9\u03bd CD8 \u03ba\u03b1\u03b9 CD4 \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd (\u03bc\u03ad\u03c3\u03c9 MHC-I \u03ba\u03b1\u03b9 \u039c\u0397C-II \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03bf\u03b9\u03c7\u03b1).<\/li>\n
            4. \u039c\u03bf\u03bd\u03bf\u03c0\u03ac\u03c4\u03b9 \u03ba\u03bf\u03ba\u03ba\u03af\u03c9\u03bd perforins\/granzyme \u03c4\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03c4\u03bf\u03be\u03b9\u03ba\u03ce\u03bd \u03a4 \u03ba\u03b1\u03b9 \u039d\u039a \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd.<\/li>\n
            5. NK \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b1 \u03b1\u03c0\u03cc \u03ba\u03c5\u03c4\u03bf\u03ba\u03af\u03bd\u03b5\u03c2.<\/li>\n<\/ol>\n
              6.2. \u03a7\u03c5\u03bc\u03b9\u03ba\u03ae \u03b1\u03bd\u03bf\u03c3\u03af\u03b1<\/b><\/h5>\n
                \n
              1. \u0391\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03c4\u03bf\u03c5 TSH-R.<\/li>\n
              2. \u039a\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03c4\u03bf\u03be\u03b9\u03ba\u03ae \u03b4\u03c1\u03ac\u03c3\u03b7 \u03c4\u03c9\u03bd anti-TPO \u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03bc\u03ad\u03c3\u03c9 \u03c3\u03c5\u03bc\u03c0\u03bb\u03b7\u03c1\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2.<\/li>\n<\/ol>\n

                \u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03c4\u03c9\u03bd \u03c0\u03b1\u03c1\u03b1\u03c0\u03ac\u03bd\u03c9 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03ce\u03bd, \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c0\u03c9\u03c2 \u03b7 \u03b1\u03c0\u03cc\u03c0\u03c4\u03c9\u03c3\u03b7 \u03bc\u03ad\u03c3\u03c9 \u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7\u03c2 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bd\u03b4\u03b5\u03c4\u03ce\u03bd \u03b8\u03b1\u03bd\u03ac\u03c4\u03bf\u03c5 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03c6\u03ac\u03bd\u03b5\u03b9\u03b1 \u03c4\u03c9\u03bd \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c4\u03c9\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd, \u03ad\u03c7\u03b5\u03b9 \u03c4\u03bf\u03bd \u03ba\u03c5\u03c1\u03af\u03b1\u03c1\u03c7\u03bf \u03c1\u03cc\u03bb\u03bf.<\/p>\n

                7. \u039f \u03c1\u03cc\u03bb\u03bf\u03c2 \u03c4\u03b7\u03c2 \u03b1\u03c0\u03cc\u03c0\u03c4\u03c9\u03c3\u03b7\u03c2 \u03c3\u03c4\u03b7 \u0398\u0391<\/b><\/h4>\n
                \u00a07.1. \u0391\u03c0\u03bf\u03c0\u03c4\u03c9\u03c4\u03b9\u03ba\u03ac \u03bc\u03bf\u03bd\u03bf\u03c0\u03ac\u03c4\u03b9\u03b1<\/b><\/h5>\n

                \u0397 \u03b1\u03c0\u03cc\u03c0\u03c4\u03c9\u03c3\u03b7 \u03ae \u03c0\u03c1\u03bf\u03b3\u03c1\u03b1\u03bc\u03bc\u03b1\u03c4\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03c2 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03cc\u03c2 \u03b8\u03ac\u03bd\u03b1\u03c4\u03bf\u03c2 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03b5\u03bd\u03cc\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c1\u03c1\u03ac\u03ba\u03c4\u03b7 \u03c0\u03c1\u03c9\u03c4\u03b5\u03bf\u03bb\u03c5\u03c4\u03b9\u03ba\u03ce\u03bd \u03b5\u03bd\u03b6\u03cd\u03bc\u03c9\u03bd (\u03ba\u03b1\u03c3\u03c0\u03ac\u03c3\u03b5\u03c2) \u03bc\u03b5 \u03c4\u03b5\u03bb\u03b9\u03ba\u03cc \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03b7\u03bd \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03c1\u03bf\u03c6\u03ae \u03c4\u03bf\u03c5 \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03bf\u03c5. \u0397 \u03c3\u03cd\u03bd\u03b4\u03b5\u03c3\u03b7 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ce\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03c9\u03bd \u03b8\u03b1\u03bd\u03ac\u03c4\u03bf\u03c5 \u03bc\u03b5 \u03c4\u03bf\u03c5\u03c2 \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03bf\u03b9\u03c7\u03bf\u03c5\u03c2 \u03b4\u03b9\u03b1\u03bc\u03b5\u03bc\u03b2\u03c1\u03b1\u03bd\u03b9\u03ba\u03bf\u03cd\u03c2 \u03c3\u03c5\u03bd\u03b4\u03ad\u03c4\u03b5\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03ad\u03bd\u03b1 \u03b2\u03b1\u03c3\u03b9\u03ba\u03cc \u03c4\u03c1\u03cc\u03c0\u03bf \u03ad\u03bd\u03b1\u03c1\u03be\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03bc\u03b5\u03c4\u03ac\u03b4\u03bf\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03b1\u03c0\u03bf\u03c0\u03c4\u03c9\u03c4\u03b9\u03ba\u03bf\u03cd \u03c3\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c3\u03c4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c0\u03bf\u03c5 \u03c6\u03ad\u03c1\u03bf\u03c5\u03bd \u03c4\u03bf\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1. \u03a4\u03b1 \u03b4\u03cd\u03bf \u03c0\u03b9\u03bf \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03b6\u03b5\u03cd\u03b3\u03b7 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03c9\u03bd-\u03c3\u03c5\u03bd\u03b4\u03b5\u03c4\u03ce\u03bd \u03c0\u03bf\u03c5 \u03ad\u03c7\u03bf\u03c5\u03bd \u03bc\u03b5\u03bb\u03b5\u03c4\u03b7\u03b8\u03b5\u03af \u03c3\u03b5 \u03c3\u03c7\u03ad\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b7 \u0398\u0391 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf Fas\/Fas ligand (FasL) \u03ba\u03b1\u03b9 \u03c4\u03bf DR4-DR5 (TRAILR-1, TRAILR-2) \/TRAIL (TNF-related apoptosis inducing ligand) (2,97,169-171) (\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 2<\/b>). \u039f \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1\u03c2 Fas \u03b1\u03bd\u03ae\u03ba\u03b5\u03b9 \u03c3\u03c4\u03b7\u03bd \u03bf\u03b9\u03ba\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1 \u03c4\u03c9\u03bd TNF \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c3\u03cd\u03bd\u03b4\u03b5\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03bc\u03b5 \u03c4\u03bf\u03bd FasL \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03b5 \u03b1\u03c0\u03cc\u03c0\u03c4\u03c9\u03c3\u03b7 \u03c4\u03bf \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03bf \u03c0\u03bf\u03c5 \u03c4\u03bf\u03bd \u03c6\u03ad\u03c1\u03b5\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03c6\u03ac\u03bd\u03b5\u03b9\u03b1 \u03c4\u03bf\u03c5. \u0394\u03b9\u03b1\u03bb\u03c5\u03c4\u03ad\u03c2 \u03bc\u03bf\u03c1\u03c6\u03ad\u03c2 \u03c4\u03c9\u03bd Fas (sFas) \u03ba\u03b1\u03b9 FasL (sFaL) \u03ad\u03c7\u03bf\u03c5\u03bd \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03b1\u03bd\u03b1\u03b3\u03bd\u03c9\u03c1\u03b9\u03c3\u03c4\u03b5\u03af. To sFas \u03c3\u03c5\u03bd\u03b4\u03b5\u03cc\u03bc\u03b5\u03bd\u03bf \u03bc\u03b5 \u03c4\u03bf\u03bd FasL, \u03b1\u03bd\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b1\u03c0\u03cc\u03c0\u03c4\u03c9\u03c3\u03b7 (172), \u03b5\u03bd\u03ce \u03c4\u03bf sFasL \u03b8\u03b5\u03c9\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03c0\u03c9\u03c2 \u03ad\u03c0\u03b5\u03b9\u03c4\u03b1 \u03b1\u03c0\u03cc \u03c3\u03cd\u03bd\u03b4\u03b5\u03c3\u03ae \u03c4\u03bf\u03c5 \u03bc\u03b5 \u03c4\u03bf\u03bd Fas \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03c0\u03ac\u03b3\u03b5\u03b9 \u03c4\u03bf\u03c5\u03c2 \u03b1\u03c0\u03bf\u03c0\u03c4\u03c9\u03c4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03cd\u03c2 (173) \u03b1\u03bd \u03ba\u03b1\u03b9 \u03bf\u03b9 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b1\u03bd\u03c4\u03b9\u03ba\u03c1\u03bf\u03c5\u03cc\u03bc\u03b5\u03bd\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1. O \u03c3\u03c5\u03bd\u03b4\u03ad\u03c4\u03b7\u03c2 TRAIL \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03c3\u03b5 \u03b4\u03b9\u03b1\u03bc\u03b5\u03bc\u03b2\u03c1\u03b1\u03bd\u03b9\u03ba\u03ae \u03ba\u03b1\u03b9 \u03b4\u03b9\u03b1\u03bb\u03c5\u03c4\u03ae \u03bc\u03bf\u03c1\u03c6\u03ae.<\/p>\n

                \n

                \"10.10-figure2\"<\/p>\n

                \u00a0<\/b><\/p>\n

                \u0395\u03b9\u03ba\u03cc\u03bd\u03b1 2.<\/b><\/em> \u03a0\u03b9\u03b8\u03b1\u03bd\u03ac \u03bc\u03bf\u03bd\u03c4\u03ad\u03bb\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03bf \u03c1\u03cc\u03bb\u03bf \u03c4\u03b7\u03c2 Fas-\u03b5\u03c0\u03b1\u03b3\u03cc\u03bc\u03b5\u03bd\u03b7\u03c2 \u03b1\u03c0\u03cc\u03c0\u03c4\u03c9\u03c3\u03b7\u03c2 \u03c3\u03c4\u03b7 \u0398\u0391. (a) \u0395\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b1 \u03b5\u03bd\u03b4\u03bf\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03a4 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03c5\u03bd \u03ba\u03c5\u03c4\u03bf\u03ba\u03af\u03bd\u03b5\u03c2, \u03bf\u03b9 \u03bf\u03c0\u03bf\u03af\u03b5\u03c2 \u03b5\u03c0\u03ac\u03b3\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b1\u03c0\u03bf\u03c0\u03c4\u03c9\u03c4\u03b9\u03ba\u03bf\u03cd \u03bc\u03bf\u03bd\u03bf\u03c0\u03b1\u03c4\u03b9\u03bf\u03cd Fas \u03c3\u03c4\u03b1 \u03b8\u03c5\u03c1\u03b5\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1, \u03bf\u03b4\u03b7\u03b3\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b1 \u03c3\u03b5 \u03b1\u03c0\u03cc\u03c0\u03c4\u03c9\u03c3\u03b7 \u03bb\u03cc\u03b3\u03c9 \u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7\u03c2 \u03bc\u03b5 \u03c4\u03bf FasL \u03c0\u03bf\u03c5 \u03b5\u03ba\u03c6\u03c1\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03c6\u03ac\u03bd\u03b5\u03b9\u03b1 \u03c4\u03c9\u03bd \u03a4 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03ae \u03bc\u03b5 \u03c4\u03bf sFasL \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ad\u03c1\u03c7\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b1 \u03a4 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1. (b) \u03a4\u03b1\u03c5\u03c4\u03cc\u03c7\u03c1\u03bf\u03bd\u03b7 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 Fas \u03ba\u03b1\u03b9 FasL \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03c6\u03ac\u03bd\u03b5\u03b9\u03b1 \u03c4\u03c9\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bf\u03b4\u03b7\u03b3\u03ae\u03c3\u03b5\u03b9 \u03c3\u03c4\u03b7\u03bd \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03c1\u03bf\u03c6\u03ae \u03c4\u03bf\u03c5\u03c2 \u03bc\u03ad\u03c3\u03c9 \u201c\u03b1\u03b4\u03b5\u03bb\u03c6\u03bf\u03ba\u03c4\u03bf\u03bd\u03af\u03b1\u03c2\u201d. (c) \u03a3\u03cd\u03bd\u03b4\u03b5\u03c3\u03b7 \u03c4\u03bf\u03c5 FasL, \u03c0\u03bf\u03c5 \u03b5\u03ba\u03c6\u03c1\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03c6\u03ac\u03bd\u03b5\u03b9\u03b1 \u03c4\u03c9\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd, \u03bc\u03b5 \u03c4\u03bf\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 Fas \u03c0\u03bf\u03c5 \u03b5\u03ba\u03c6\u03c1\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b5\u03bd\u03b4\u03bf\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bf\u03b4\u03b7\u03b3\u03ae\u03c3\u03b5\u03b9 \u03c3\u03c4\u03bf\u03bd \u03b1\u03c0\u03bf\u03c0\u03c4\u03c9\u03c4\u03b9\u03ba\u03cc \u03b8\u03ac\u03bd\u03b1\u03c4\u03bf \u03c4\u03c9\u03bd \u03c4\u03b5\u03bb\u03b5\u03c5\u03c4\u03b1\u03af\u03c9\u03bd. <\/i>Fountoulakis S & Tsatsoulis A, Clin Endocrinol (Oxf) 2004, with permission.<\/p>\n

                \n

                \u0397 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c0\u03c1\u03bf\u03b1\u03bd\u03b1\u03c6\u03b5\u03c1\u03b8\u03ad\u03bd\u03c4\u03c9\u03bd \u03b4\u03b9\u03b1\u03bc\u03b5\u03bc\u03b2\u03c1\u03b1\u03bd\u03b9\u03ba\u03ce\u03bd \u03bc\u03bf\u03c1\u03af\u03c9\u03bd \u03b1\u03c0\u03cc \u03c4\u03b1 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b5\u03be\u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03b5\u03af \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b5\u03b4\u03af\u03bf \u03b1\u03bd\u03c4\u03b9\u03c0\u03b1\u03c1\u03b1\u03b8\u03ad\u03c3\u03b5\u03c9\u03bd. \u03a3\u03ae\u03bc\u03b5\u03c1\u03b1 \u03b8\u03b5\u03c9\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03c0\u03c9\u03c2 \u03c4\u03b1 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b5\u03ba\u03c6\u03c1\u03ac\u03b6\u03bf\u03c5\u03bd \u03ba\u03b1\u03b8\u03bf\u03bb\u03b9\u03ba\u03ac \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bd\u03b5\u03c7\u03ce\u03c2 Fas \u03ba\u03b1\u03b9 DR4, DR5, \u03b1\u03bb\u03bb\u03ac \u03c4\u03b1 \u03b1\u03c0\u03bf\u03c0\u03c4\u03c9\u03c4\u03b9\u03ba\u03ac \u03bc\u03bf\u03bd\u03bf\u03c0\u03ac\u03c4\u03b9\u03b1 \u03c0\u03bf\u03c5 \u03be\u03b5\u03ba\u03b9\u03bd\u03bf\u03cd\u03bd \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5\u03c2 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03b5\u03af\u03c2 \u03b1\u03c5\u03c4\u03bf\u03cd\u03c2 \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03bf\u03c5\u03bd \u03c5\u03c0\u03cc \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03c3\u03c5\u03bd\u03b8\u03ae\u03ba\u03b5\u03c2 \u03b1\u03bd\u03b5\u03bd\u03b5\u03c1\u03b3\u03ac (97, 174). \u0397 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03b1\u03c5\u03c4\u03ae \u03b1\u03af\u03c1\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03c9\u03bd \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03ce\u03bd \u03c0\u03c1\u03bf-\u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03c9\u03b4\u03ce\u03bd \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03ba\u03b9\u03bd\u03ce\u03bd (IFN-\u03b3 + IL-1\u03b2 \u03ba\u03b1\u03b9 IFN-\u03b3 + TNF-\u03b1) (139).<\/p>\n

                \u03a4\u03b1 \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 FasL \u03b1\u03c0\u03cc \u03c4\u03b1 \u03b8\u03c5\u03c1\u03b5\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bb\u03b9\u03b3\u03cc\u03c4\u03b5\u03c1\u03bf \u03c3\u03b1\u03c6\u03ae, \u03b1\u03bb\u03bb\u03ac \u03bf\u03b9 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c3\u03c5\u03bc\u03c6\u03c9\u03bd\u03bf\u03cd\u03bd \u03cc\u03c4\u03b9 \u03c4\u03b1 \u03b8\u03c5\u03c1\u03b5\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b4\u03b5\u03bd \u03b5\u03ba\u03c6\u03c1\u03ac\u03b6\u03bf\u03c5\u03bd FasL, \u03af\u03c3\u03c9\u03c2 \u03c0\u03b1\u03c1\u03ac \u03bc\u03cc\u03bd\u03bf \u03c3\u03b5 \u03c0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2, \u201c\u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03ce\u03bd\u03c4\u03b1\u03c2\u201d \u03c4\u03bf \u03b3\u03b9\u03b1 \u03b5\u03be\u03bf\u03c5\u03b4\u03b5\u03c4\u03b5\u03c1\u03ce\u03c3\u03bf\u03c5\u03bd \u03b1\u03c0\u03b5\u03b9\u03bb\u03b7\u03c4\u03b9\u03ba\u03ac \u03b3\u03b9\u03b1 \u03b1\u03c5\u03c4\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1. \u03a5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03c4\u03ad\u03bb\u03bf\u03c2 \u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2 \u03c0\u03c9\u03c2 \u03b7 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03b1\u03bd\u03c4\u03b9\u03b1\u03c0\u03bf\u03c0\u03c4\u03c9\u03c4\u03b9\u03ba\u03ce\u03bd \u03bc\u03bf\u03c1\u03af\u03c9\u03bd \u03cc\u03c0\u03c9\u03c2 \u03c4\u03bf Bcl-2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03b5\u03af \u03b5\u03af\u03c4\u03b5 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b5\u03af\u03c4\u03b5 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c9\u03c2 \u03bc\u03ad\u03c3\u03bf \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7\u03c2 (174,175).<\/p>\n

                7.2. \u0391\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ce\u03bd \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd-\u03b8\u03c5\u03c1\u03b5\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c3\u03c4\u03b7 \u0398\u0391- \u0391\u03c0\u03cc\u03c0\u03c4\u03c9\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u0398\u0391<\/b><\/h5>\n
                7.2.1. \u0398\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03af\u03c4\u03b9\u03b4\u03b1 <\/b>Hashimoto<\/b><\/i><\/b><\/h6>\n

                \u0397 \u03b1\u03c0\u03cc\u03c0\u03c4\u03c9\u03c3\u03b7 \u03b8\u03b5\u03c9\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03c9\u03c2 \u03bf \u03b2\u03b1\u03c3\u03b9\u03ba\u03cc\u03c2 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03c1\u03bf\u03c6\u03ae\u03c2 \u03c4\u03c9\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u0397\u03a4 (2). \u0394\u03cd\u03bf \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf\u03b9 \u03ba\u03cd\u03c1\u03b9\u03b5\u03c2 \u03b8\u03b5\u03c9\u03c1\u03af\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b4\u03b9\u03b1\u03c4\u03c5\u03c0\u03c9\u03b8\u03b5\u03af. \u0397 \u03c0\u03c1\u03ce\u03c4\u03b7, \u03c0\u03bf\u03c5 \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03ba\u03b5\u03c1\u03b4\u03af\u03b6\u03b5\u03b9 \u03ad\u03b4\u03b1\u03c6\u03bf\u03c2 \u03c3\u03cd\u03bc\u03c6\u03c9\u03bd\u03b1 \u03bc\u03b5 \u03c4\u03b1 \u03c4\u03b5\u03bb\u03b5\u03c5\u03c4\u03b1\u03af\u03b1 \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1, \u03c5\u03c0\u03bf\u03c3\u03c4\u03b7\u03c1\u03af\u03b6\u03b5\u03b9 \u03c0\u03c9\u03c2 \u03bf \u03b1\u03c0\u03bf\u03c0\u03c4\u03c9\u03c4\u03b9\u03ba\u03cc\u03c2 \u03b8\u03ac\u03bd\u03b1\u03c4\u03bf\u03c2 \u03c4\u03c9\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03b5\u03c0\u03ac\u03b3\u03b5\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b1\u03bd \u03b5\u03bd\u03b4\u03bf\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c0\u03bf\u03c5 \u03b5\u03ba\u03c6\u03c1\u03ac\u03b6\u03bf\u03c5\u03bd FasL \u03ba\u03b1\u03b9 \u03c4\u03b1\u03c5\u03c4\u03cc\u03c7\u03c1\u03bf\u03bd\u03b1 Bcl-2 \u03ad\u03c1\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b5\u03c0\u03b1\u03c6\u03ae \u03bc\u03b5 \u03c4\u03bf\u03bd Fas \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03c4\u03c9\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd (2). \u03a4\u03b1 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7\u03bd \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03ae \u03c4\u03bf\u03c5\u03c2 \u03b1\u03c0\u03cc APC \u03c0\u03bf\u03c5 \u03c6\u03ad\u03c1\u03bf\u03c5\u03bd \u03927.1 \u03c3\u03c5\u03bd\u03b4\u03b9\u03b5\u03b3\u03b5\u03c1\u03c4\u03b9\u03ba\u03ac \u03bc\u03cc\u03c1\u03b9\u03b1 \u03ae \u03ba\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03af\u03b4\u03b9\u03b1 \u03c4\u03b1 \u03b8\u03c5\u03c1\u03b5\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c0\u03bf\u03c5 \u03c6\u03ad\u03c1\u03bf\u03c5\u03bd \u03927.1 (11), \u03b5\u03ba\u03ba\u03c1\u03af\u03bd\u03bf\u03c5\u03bd \u03c4\u03bf\u03c0\u03b9\u03ba\u03ac \u03a4h1 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03ba\u03af\u03bd\u03b5\u03c2. \u039f\u03b9 \u03c4\u03b5\u03bb\u03b5\u03c5\u03c4\u03b1\u03af\u03b5\u03c2 \u03ac\u03c1\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03bf\u03c5 Fas\/FasL \u03bc\u03bf\u03bd\u03bf\u03c0\u03b1\u03c4\u03b9\u03bf\u03cd, \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03c3\u03c4\u03b1 \u03b8\u03c5\u03c1\u03b5\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1, \u03ba\u03b1\u03b8\u03b9\u03c3\u03c4\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b1 \u03b5\u03c5\u03ac\u03bb\u03c9\u03c4\u03b1 \u03c3\u03b5 \u03b1\u03c0\u03cc\u03c0\u03c4\u03c9\u03c3\u03b7.<\/p>\n

                \u0391\u03c0\u03cc \u03c4\u03b7\u03bd \u03ac\u03bb\u03bb\u03b7 \u03c0\u03bb\u03b5\u03c5\u03c1\u03ac \u03bf\u03b9 Giordano et<\/i> <\/i>al<\/i>.<\/i>, (175) \u03c5\u03c0\u03bf\u03c3\u03c4\u03b7\u03c1\u03af\u03b6\u03bf\u03c5\u03bd \u03ad\u03bd\u03b1\u03bd \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc \u201c\u03b1\u03b4\u03b5\u03bb\u03c6\u03bf\u03ba\u03c4\u03bf\u03bd\u03af\u03b1\u03c2\u201d (fratricide) \u03c4\u03c9\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03bb\u03cc\u03b3\u03c9 \u03c4\u03b1\u03c5\u03c4\u03cc\u03c7\u03c1\u03bf\u03bd\u03b7\u03c2 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7\u03c2 Fas \u03ba\u03b1\u03b9 FasL \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03c6\u03ac\u03bd\u03b5\u03b9\u03b1 \u03c4\u03bf\u03c5\u03c2. \u0397 \u03b8\u03b5\u03c9\u03c1\u03af\u03b1 \u03b1\u03c5\u03c4\u03ae \u03b4\u03ad\u03c7\u03b5\u03c4\u03b1\u03b9 \u03c0\u03c9\u03c2 \u03c4\u03b1 \u03b8\u03c5\u03c1\u03b5\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03b5\u03ba\u03c6\u03c1\u03ac\u03b6\u03bf\u03c5\u03bd FasL \u03c4\u03bf \u03bf\u03c0\u03bf\u03af\u03bf \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03bd\u03b5\u03c1\u03b3\u03cc \u03ba\u03b1\u03b9 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03cc, \u03ba\u03ac\u03c4\u03b9 \u03bc\u03b5 \u03c4\u03bf \u03bf\u03c0\u03bf\u03af\u03bf \u03c0\u03ac\u03bd\u03c4\u03c9\u03c2 \u03b4\u03b5 \u03c3\u03c5\u03bc\u03c6\u03c9\u03bd\u03bf\u03cd\u03bd \u03bf\u03b9 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2.<\/p>\n

                \u0386\u03bb\u03bb\u03b1 \u03bc\u03cc\u03c1\u03b9\u03b1 \u03c0\u03bf\u03c5 \u03b5\u03bc\u03c0\u03bb\u03ad\u03ba\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03c0\u03b1\u03b8\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 \u0397\u03a4 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03b1 \u03b4\u03b9\u03b1\u03bb\u03c5\u03c4\u03ac sFas \u03ba\u03b1\u03b9 sFasL. \u03a4\u03bf \u03c0\u03c1\u03bf\u03b5\u03c1\u03c7\u03cc\u03bc\u03b5\u03bd\u03bf \u03b1\u03c0\u03cc \u03c4\u03b1 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 sFasL \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03c0\u03ac\u03b3\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b1\u03c0\u03cc\u03c0\u03c4\u03c9\u03c3\u03b7 \u03c3\u03b5 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c0\u03bf\u03c5 \u03c6\u03ad\u03c1\u03bf\u03c5\u03bd Fas (175). \u0395\u03c0\u03af\u03c3\u03b7\u03c2 \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03bf\u03c5 sFas \u03ad\u03c7\u03bf\u03c5\u03bd \u03b2\u03c1\u03b5\u03b8\u03b5\u03af \u03bc\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03b1 \u03c3\u03c4\u03b7 \u0397\u03a4, \u03bf\u03b4\u03b7\u03b3\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c3\u03c4\u03b7\u03bd \u03c5\u03c0\u03cc\u03b8\u03b5\u03c3\u03b7 \u03c0\u03c9\u03c2 \u03c4\u03bf \u03b1\u03ba\u03ad\u03c1\u03b1\u03b9\u03bf \u03b4\u03b9\u03b1\u03bc\u03b5\u03bc\u03b2\u03c1\u03b1\u03bd\u03b9\u03ba\u03cc Fas, \u03b1\u03c0\u03cc \u03c4\u03bf \u03bf\u03c0\u03bf\u03af\u03bf \u03c0\u03c1\u03bf\u03ad\u03c1\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9, \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf \u03ba\u03b1\u03b9 \u03b5\u03c0\u03ac\u03b3\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b1\u03c0\u03cc\u03c0\u03c4\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c0\u03bf\u03c5 \u03c4\u03bf \u03c6\u03ad\u03c1\u03bf\u03c5\u03bd. \u0391\u03ba\u03cc\u03bc\u03b1 \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2 \u03c0\u03c9\u03c2 \u03b7 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c0\u03c1\u03bf\u03c3\u03c4\u03b1\u03c4\u03b5\u03c5\u03c4\u03b9\u03ba\u03bf\u03cd \u03bc\u03bf\u03c1\u03af\u03bf\u03c5 Bcl-2, \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03bf \u03c3\u03c4\u03b1 \u03b8\u03c5\u03c1\u03b5\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03bc\u03b5 \u0397\u03a4 (175,176) (\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 3<\/b>).<\/p>\n

                \n

                \"10.10-figure3\"<\/p>\n

                \u00a0<\/b><\/p>\n

                \u0395\u03b9\u03ba\u03cc\u03bd\u03b1 3.<\/b><\/em> \u03a3\u03c5\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03ac \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1 \u03c4\u03c9\u03bd Fas \u03ba\u03b1\u03b9 DR4\/DR5 \u03b1\u03c0\u03bf\u03c0\u03c4\u03c9\u03c4\u03b9\u03ba\u03ce\u03bd \u03bc\u03bf\u03bd\u03bf\u03c0\u03b1\u03c4\u03b9\u03ce\u03bd. \u039c\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u03c4\u03b7 \u03c3\u03cd\u03bd\u03b4\u03b5\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03bf FasL, \u03bf \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1\u03c2 Fas \u03c4\u03c1\u03b9\u03bc\u03b5\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03b5\u03c0\u03b9\u03c3\u03c4\u03c1\u03b1\u03c4\u03b5\u03cd\u03b5\u03b9, \u03bc\u03ad\u03c3\u03c9 \u03c4\u03bf\u03c5 \u03c0\u03b5\u03b4\u03af\u03bf\u03c5 (domain) \u03b8\u03b1\u03bd\u03ac\u03c4\u03bf\u03c5, \u03c4\u03b7\u03bd \u03c0\u03c1\u03c9\u03c4\u03b5\u03b9\u03bd\u03b7 FADD (Fas-associated protein with death domain). \u0391\u03c5\u03c4\u03ae \u03bc\u03b5 \u03c4\u03b7 \u03c3\u03b5\u03b9\u03c1\u03ac \u03c4\u03b7\u03c2 \u03b5\u03c0\u03b9\u03c3\u03c4\u03c1\u03b1\u03c4\u03b5\u03cd\u03b5\u03b9 \u03ba\u03b1\u03b9 \u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03b9\u03b4\u03c1\u03ac \u03bc\u03b5 \u03c4\u03b7\u03bd \u03c0\u03c1\u03bf\u03ba\u03b1\u03c3\u03c0\u03ac\u03c3\u03b7 8. \u039f \u03c3\u03c7\u03b7\u03bc\u03b1\u03c4\u03b9\u03c3\u03bc\u03cc\u03c2 \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bc\u03c0\u03bb\u03ad\u03b3\u03bc\u03b1\u03c4\u03bf\u03c2 Fas-FADD-\u03c0\u03c1\u03bf\u03ba\u03b1\u03c3\u03c0\u03ac\u03c3\u03b7\u03c2 8 \u03b5\u03c5\u03bf\u03b4\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c0\u03c1\u03bf\u03ba\u03b1\u03c3\u03c0\u03ac\u03c3\u03b7\u03c2 8. \u0397 \u03ba\u03b1\u03c3\u03c0\u03ac\u03c3\u03b7 8 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03c4\u03b7\u03bd \u03ba\u03b1\u03c3\u03c0\u03ac\u03c3\u03b7 3 \u03ba\u03b1\u03b8\u03ce\u03c2 \u03ba\u03b1\u03b9 \u03ac\u03bb\u03bb\u03b5\u03c2 \u03ba\u03b1\u03c3\u03c0\u03ac\u03c3\u03b5\u03c2. \u039f \u03ba\u03b1\u03c4\u03b1\u03c1\u03c1\u03ac\u03ba\u03c4\u03b7\u03c2 \u03b4\u03b9\u03b1\u03b4\u03bf\u03c7\u03b9\u03ba\u03ae\u03c2 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd \u03ba\u03b1\u03c3\u03c0\u03b1\u03c3\u03ce\u03bd \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c4\u03b5\u03bb\u03b9\u03ba\u03ac \u03c3\u03c4\u03b7\u03bd \u03b1\u03c0\u03cc\u03c0\u03c4\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03bf\u03c5. \u03a4\u03bf TRAIL \u03bc\u03b5 \u03c4\u03b7 \u03c3\u03b5\u03b9\u03c1\u03ac \u03c4\u03bf\u03c5, \u03c0\u03c1\u03bf\u03c3\u03b4\u03ad\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b5\u03c0\u03b9\u03c6\u03b1\u03bd\u03b5\u03b9\u03b1\u03ba\u03bf\u03cd\u03c2 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03b5\u03af\u03c2 DR4 \u03ba\u03b1\u03b9 DR5, \u03bf\u03b9 \u03bf\u03c0\u03bf\u03af\u03bf\u03b9 \u03b5\u03c0\u03b9\u03c3\u03c4\u03c1\u03b1\u03c4\u03b5\u03cd\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03c0\u03c1\u03bf\u03ba\u03b1\u03c3\u03c0\u03ac\u03c3\u03b7 10 \u03bc\u03b5 \u03b5\u03c0\u03b1\u03ba\u03cc\u03bb\u03bf\u03c5\u03b8\u03bf \u03c4\u03b7\u03bd \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03ae \u03c4\u03b7\u03c2. \u03a3\u03c4\u03b7 \u03c3\u03c5\u03bd\u03ad\u03c7\u03b5\u03b9\u03b1 \u03b7 \u03ba\u03b1\u03c3\u03c0\u03ac\u03c3\u03b7 10 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03c4\u03b7\u03bd \u03ba\u03b1\u03c3\u03c0\u03ac\u03c3\u03b7 8, \u03b4\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03ad\u03bd\u03b1\u03c5\u03c3\u03bc\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03b1\u03c0\u03bf\u03c0\u03c4\u03c9\u03c4\u03b9\u03ba\u03cc \u03ba\u03b1\u03c4\u03b1\u03c1\u03c1\u03ac\u03ba\u03c4\u03b7 \u03c4\u03c9\u03bd \u03ba\u03b1\u03c3\u03c0\u03b1\u03c3\u03ce\u03bd. \u039c\u03ad\u03bb\u03b7 \u03c4\u03b7\u03c2 \u03c5\u03c0\u03b5\u03c1\u03bf\u03b9\u03ba\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1\u03c2 \u03c4\u03bf\u03c5 Bcl-2 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03b4\u03c1\u03ac\u03c3\u03bf\u03c5\u03bd \u03c9\u03c2 \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03c4\u03ad\u03c2 \u03c4\u03b7\u03c2 \u03b1\u03c0\u03cc\u03c0\u03c4\u03c9\u03c3\u03b7\u03c2. Fountoulakis S & Tsatsoulis A, Clin Endocrinol (Oxf) 2004, with permission.<\/p>\n

                \n

                \u03a3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03c1\u03cc\u03bb\u03bf \u03b1\u03ba\u03cc\u03bc\u03b1 \u03b4\u03b9\u03b5\u03ba\u03b4\u03b9\u03ba\u03b5\u03af \u03b7 \u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c4\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c3\u03b5 TRAIL\/DR4-DR5 \u03b1\u03c0\u03cc\u03c0\u03c4\u03c9\u03c3\u03b7 \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03ba\u03af\u03bd\u03b5\u03c2 \u03c4\u03c9\u03bd \u03a4 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd (2). \u03a4\u03ad\u03bb\u03bf\u03c2 \u03b7 \u03b1\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1 \u03ae \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b5\u03c0\u03b9\u03ba\u03bf\u03b9\u03bd\u03c9\u03bd\u03af\u03b1\u03c2 \u03c4\u03c9\u03bd \u03b3\u03b5\u03b9\u03c4\u03bf\u03bd\u03b9\u03ba\u03ce\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03bc\u03ad\u03c3\u03c9 \u03c4\u03c9\u03bd \u03c7\u03b1\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ce\u03bd \u03b5\u03bd\u03ce\u03c3\u03b5\u03c9\u03bd (gap junctions), \u03c0\u03bf\u03c5 \u03ad\u03c7\u03b5\u03b9 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b7\u03b8\u03b5\u03af \u03c3\u03b5 \u03c0\u03b5\u03b9\u03c1\u03b1\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03bc\u03bf\u03bd\u03c4\u03ad\u03bb\u03b1 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae\u03c2 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03bf\u03c3\u03af\u03b1\u03c2 \u03af\u03c3\u03c9\u03c2 \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03b5 \u03ad\u03bd\u03b1\u03bd \u03c4\u03cd\u03c0\u03bf \u03b1\u03c0\u03bf\u03c0\u03c4\u03c9\u03c4\u03b9\u03ba\u03bf\u03cd \u03b8\u03b1\u03bd\u03ac\u03c4\u03bf\u03c5 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b5\u03bb\u03bb\u03b7\u03bd\u03b9\u03ba\u03ae \u03bf\u03bd\u03bf\u03bc\u03b1\u03c3\u03af\u03b1 anoikis (\u03ac\u03bd\u03b5\u03c5 \u03bf\u03af\u03ba\u03bf\u03c5) (177).<\/p>\n

                7.2.2. <\/b>N<\/b>\u03cc\u03c3\u03bf\u03c2 \u03c4\u03bf\u03c5 <\/b>Graves<\/b><\/b><\/h6>\n

                \u03a3\u03c4\u03b7 GD \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c0\u03c9\u03c2 \u03b5\u03c0\u03b9\u03ba\u03c1\u03b1\u03c4\u03bf\u03cd\u03bd \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03af \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd, \u03af\u03c3\u03c9\u03c2 \u03bb\u03cc\u03b3\u03c9 \u03c4\u03b7\u03c2 \u03b5\u03c0\u03b9\u03ba\u03c1\u03ac\u03c4\u03b7\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd Th2 \u03ba\u03c5\u03c4\u03c4\u03bf\u03ba\u03b9\u03bd\u03ce\u03bd, \u03c0\u03c1\u03bf\u03b5\u03c1\u03c7\u03cc\u03bc\u03b5\u03bd\u03c9\u03bd \u03b1\u03c0\u03cc \u03927.2 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd (2,178). \u0388\u03c4\u03c3\u03b9 \u03c5\u03c0\u03b5\u03c1\u03b9\u03c3\u03c7\u03cd\u03b5\u03b9 \u03b7 \u03c7\u03c5\u03bc\u03b9\u03ba\u03ae \u03b1\u03bd\u03bf\u03c3\u03af\u03b1 \u03ba\u03b1\u03b9 \u03b7 \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03c0\u03bf\u03c5 \u03b4\u03b9\u03b5\u03b3\u03b5\u03af\u03c1\u03bf\u03c5\u03bd \u03c4\u03bf\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03c4\u03b7\u03c2 TSH, \u03bf\u03b4\u03b7\u03b3\u03bf\u03cd\u03bd \u03c3\u03b5 \u03c5\u03c0\u03b5\u03c1\u03c0\u03bb\u03b1\u03c3\u03af\u03b1 \u03c4\u03c9\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03ba\u03b1\u03b9 \u03af\u03c3\u03c9\u03c2 \u03ad\u03c7\u03bf\u03c5\u03bd \u03ba\u03b1\u03b9 \u03b1\u03bd\u03c4\u03b9\u03b1\u03c0\u03bf\u03c0\u03c4\u03c9\u03c4\u03b9\u03ba\u03cc \u03c1\u03cc\u03bb\u03bf. \u0395\u03c0\u03af\u03c3\u03b7\u03c2 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 Bcl-2 \u03c3\u03c4\u03b1 \u03b8\u03c5\u03c1\u03b5\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1, \u03b5\u03bd\u03ce \u03b7 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03bc\u03bf\u03c1\u03af\u03c9\u03bd \u03cc\u03c0\u03c9\u03c2 \u03c4\u03bf FasL \u03ba\u03b1\u03b9 \u03c4\u03bf TRAIL \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03c0\u03ac\u03b3\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03c6\u03ac\u03bd\u03b5\u03b9\u03b1 \u03c4\u03bf\u03c5\u03c2 (2,170,178), \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ce\u03bd\u03c4\u03b1\u03c2 \u03ad\u03bd\u03b1 \u03b9\u03c3\u03c7\u03c5\u03c1\u03cc \u03cc\u03c0\u03bb\u03bf \u03c3\u03c4\u03b7 \u03bc\u03ac\u03c7\u03b7 \u03b5\u03bd\u03ac\u03bd\u03c4\u03b9\u03b1 \u03c4\u03c9\u03bd \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd, \u03c4\u03b1 \u03bf\u03c0\u03bf\u03af\u03b1 \u03b5\u03ba\u03c6\u03c1\u03ac\u03b6\u03bf\u03c5\u03bd Fas \u03ba\u03b1\u03b9 \u03bc\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 FasL \u03ba\u03b1\u03b9 Bcl-2.<\/p>\n

                \u03a0\u03b5\u03c1\u03bd\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c3\u03c4\u03b7\u03bd \u03b1\u03c4\u03c1\u03bf\u03c6\u03b9\u03ba\u03ae \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03af\u03c4\u03b9\u03b4\u03b1 \u03b1\u03be\u03af\u03b6\u03b5\u03b9 \u03bd\u03b1 \u03c4\u03bf\u03bd\u03b9\u03c3\u03c4\u03b5\u03af \u03c0\u03c9\u03c2 \u03b7 \u03c5\u03c0\u03bf\u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b1 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03c0\u03bf\u03c5 \u03c6\u03ad\u03c1\u03bf\u03c5\u03bd \u03b1\u03bd\u03c4\u03b1\u03b3\u03c9\u03bd\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03c0\u03c1\u03bf\u03c2 \u03c4\u03bf\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03c4\u03b7\u03c2 TSH \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b8\u03b5\u03c9\u03c1\u03b7\u03b8\u03b5\u03af \u03c9\u03c2 \u03c4\u03bf \u03b1\u03bd\u03c4\u03af\u03b8\u03b5\u03c4\u03bf \u03ac\u03ba\u03c1\u03bf \u03c4\u03b7\u03c2 GD. K\u03b1\u03b9 \u03b5\u03b4\u03ce \u03ad\u03c7\u03bf\u03c5\u03bc\u03b5 \u03b5\u03c0\u03b9\u03ba\u03c1\u03ac\u03c4\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c7\u03c5\u03bc\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03bf\u03c3\u03af\u03b1\u03c2, \u03b5\u03bd\u03ce \u03bf \u03c0\u03b1\u03b8\u03bf\u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03cc\u03c2 \u03c1\u03cc\u03bb\u03bf\u03c2 \u03c4\u03c9\u03bd \u03b1\u03bd\u03c4\u03b1\u03b3\u03c9\u03bd\u03b9\u03c3\u03c4\u03b9\u03ba\u03ce\u03bd anti-TSH \u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03b5\u03bd\u03b9\u03c3\u03c7\u03cd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b9\u03ba\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03ac \u03c4\u03bf\u03c5\u03c2 \u03bd\u03b1 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03bf\u03cd\u03bd \u03c0\u03b1\u03c1\u03bf\u03b4\u03b9\u03ba\u03cc \u03bd\u03b5\u03bf\u03b3\u03bd\u03b9\u03ba\u03cc \u03c5\u03c0\u03bf\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03c3\u03bc\u03cc (179).<\/p>\n

                \u03a4\u03ad\u03bb\u03bf\u03c2 \u03bf\u03b9 \u03c5\u03c0\u03cc\u03bb\u03bf\u03b9\u03c0\u03b5\u03c2 \u03bc\u03bf\u03c1\u03c6\u03ad\u03c2 \u03c4\u03b7\u03c2 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1\u03c2 \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03b7\u03c2 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03af\u03c4\u03b9\u03b4\u03b1\u03c2 (\u03c3\u03c0\u03bf\u03c1\u03b1\u03b4\u03b9\u03ba\u03ae \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03af\u03c4\u03b9\u03b4\u03b1 \u03ba\u03b1\u03b9 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03af\u03c4\u03b9\u03b4\u03b1 \u03c4\u03b7\u03c2 \u03bb\u03bf\u03c7\u03b5\u03af\u03b1\u03c2) \u03bf\u03bc\u03bf\u03b9\u03ac\u03b6\u03bf\u03c5\u03bd \u03bc\u03b5 \u03c4\u03b7 \u0397\u03a4, \u03bc\u03cc\u03bd\u03bf \u03c0\u03bf\u03c5 \u03b7 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03b4\u03b9\u03ae\u03b8\u03b7\u03c3\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7\u03c0\u03b9\u03cc\u03c4\u03b5\u03c1\u03b7. \u0397 \u03b1\u03c1\u03c7\u03b9\u03ba\u03ae \u03c6\u03ac\u03c3\u03b7 \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03c1\u03bf\u03c6\u03ae \u03c4\u03c9\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03ba\u03b1\u03b9 \u03ae\u03c0\u03b9\u03b1 \u03b8\u03c5\u03c1\u03b5\u03bf\u03c4\u03bf\u03be\u03af\u03ba\u03c9\u03c3\u03b7 \u03b1\u03bb\u03bb\u03ac \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b1\u03c1\u03bf\u03b4\u03b9\u03ba\u03ae \u03ba\u03b1\u03b9 \u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03b5\u03af\u03c4\u03b1\u03b9 \u03ba\u03ac\u03c0\u03bf\u03b9\u03b5\u03c2 \u03c6\u03bf\u03c1\u03ad\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03c5\u03c0\u03bf\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae \u03c6\u03ac\u03c3\u03b7 \u03b1\u03bd\u03ac\u03c1\u03c1\u03c9\u03c3\u03b7\u03c2 \u03c0\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03b1\u03c5\u03c4\u03ae \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b1\u03c1\u03bf\u03b4\u03b9\u03ba\u03ae \u03bc\u03b5 \u03c4\u03bf\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae \u03bd\u03b1 \u03b5\u03c0\u03b9\u03c3\u03c4\u03c1\u03ad\u03c6\u03b5\u03b9 \u03c3\u03c4\u03b1\u03b4\u03b9\u03b1\u03ba\u03ac \u03c3\u03b5 \u03b5\u03c5\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae \u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7.<\/p>\n

                8. \u0395\u03c0\u03b9\u03b3\u03c1\u03b1\u03bc\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac<\/b><\/h4>\n

                \u0397 \u03ad\u03bd\u03b1\u03c1\u03be\u03b7 \u03ba\u03b1\u03b9 \u03b7 \u03b5\u03be\u03ad\u03bb\u03b9\u03be\u03b7 \u03c4\u03b7\u03c2 \u0398\u0391 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7\u03c2 \u03c0\u03b5\u03c1\u03b9\u03b2\u03b1\u03bb\u03bb\u03bf\u03bd\u03c4\u03b9\u03ba\u03ce\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03cc\u03bd\u03c4\u03c9\u03bd \u03c3\u03b5 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ac \u03c0\u03c1\u03bf\u03b4\u03b9\u03b1\u03c4\u03b5\u03b8\u03b5\u03b9\u03bc\u03ad\u03bd\u03b1 \u03ac\u03c4\u03bf\u03bc\u03b1.<\/p>\n

                  \n
                1. \u0397 \u03cd\u03c0\u03b1\u03c1\u03be\u03b7 \u03ba\u03b1\u03b9 \u03b7 \u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c0\u03bf\u03bb\u03c5\u03bc\u03bf\u03c1\u03c6\u03b9\u03c3\u03bc\u03ce\u03bd \u03c0\u03c1\u03bf\u03b4\u03b9\u03b1\u03b8\u03b5\u03c3\u03b9\u03ba\u03ce\u03bd \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03c9\u03bd (\u03cc\u03c0\u03c9\u03c2 \u03c4\u03b1 HLA-DR3, CTLA-4, FCRL3, CD40, PTPN22, \u0399L2Ra\/ CD25, TSHR, Tg, SCGB3A2 \u03ba.\u03b1) \u03b8\u03ad\u03c4\u03bf\u03c5\u03bd \u03c4\u03b7 \u03b2\u03ac\u03c3\u03b7 \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7\u03c2 \u03c4\u03b7\u03c2 \u0398\u0391. \u03a3\u03c4\u03bf \u03b1\u03c1\u03c7\u03b9\u03ba\u03cc \u03b1\u03c5\u03c4\u03cc \u03c5\u03c0\u03cc\u03b2\u03b1\u03b8\u03c1\u03bf \u03af\u03c3\u03c9\u03c2 \u03b5\u03c0\u03b9\u03b4\u03c1\u03bf\u03cd\u03bd \u03ba\u03b1\u03b9 \u03ac\u03bb\u03bb\u03bf\u03b9 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2 \u03cc\u03c0\u03c9\u03c2 \u03c4\u03b1 \u03bc\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 miRNA, \u03c4\u03b1 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b1 DAMPs \u03ba\u03b1\u03b9 \u03bf \u03bc\u03b9\u03ba\u03c1\u03bf\u03c7\u03b9\u03bc\u03b1\u03b9\u03c1\u03b9\u03c3\u03bc\u03cc\u03c2. O \u03c1\u03cc\u03bb\u03bf\u03c2 \u03c4\u03c9\u03bd miRNA \u03ad\u03c7\u03b5\u03b9 \u03bd\u03b1 \u03ba\u03ac\u03bd\u03b5\u03b9 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03ae \u03c4\u03bf\u03c5\u03c2 \u03c3\u03b5 \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1-\u03c3\u03c4\u03cc\u03c7\u03bf\u03c5\u03c2 (target genes) \u03cc\u03c0\u03c9\u03c2 \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 \u03c7\u03c5\u03bc\u03bf\u03ba\u03b9\u03bd\u03ce\u03bd \u03ba\u03b1\u03b9 \u03ac\u03bb\u03bb\u03b1 \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 \u03c3\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03bf\u03c4\u03b9\u03ba\u03ce\u03bd \u03bc\u03bf\u03bd\u03bf\u03c0\u03b1\u03c4\u03b9\u03ce\u03bd \u03ba\u03c5\u03c4\u03bf\u03ba\u03b9\u03bd\u03ce\u03bd. \u0391\u03c0\u03cc \u03c4\u03b7\u03bd \u03ac\u03bb\u03bb\u03b7 \u03c0\u03bb\u03b5\u03c5\u03c1\u03ac \u03c4\u03b1 \u03b5\u03bc\u03b2\u03c1\u03c5\u03b9\u03ba\u03ac \u03bc\u03b9\u03ba\u03c1\u03bf\u03c7\u03b9\u03bc\u03b1\u03b9\u03c1\u03b9\u03ba\u03ac \u03a4, \u039d\u039a, \u03ba\u03b1\u03b9 \u03bc\u03bf\u03bd\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1\/\u03bc\u03b1\u03ba\u03c1\u03bf\u03c6\u03ac\u03b3\u03b1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03bc\u03c0\u03bb\u03ad\u03ba\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03ad\u03bd\u03b1\u03c1\u03be\u03b7 \u0398\u0391 \u03bc\u03ad\u03c3\u03c9 \u03c4\u03c9\u03bd \u03ba\u03c5\u03c4\u03bf\u03ba\u03b9\u03bd\u03ce\u03bd \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03c5\u03bd \u03ae \u03bd\u03b1 \u03b1\u03bd\u03b1\u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c4\u03b1 \u03af\u03b4\u03b9\u03b1 \u03c9\u03c2 \u2018\u03bc\u03b5\u03c1\u03b9\u03ba\u03ce\u03c2\u2019\u03b5\u03be\u03c9\u03b3\u03b5\u03bd\u03ae. \u0395\u03c0\u03b9\u03c0\u03c1\u03cc\u03c3\u03b8\u03b5\u03c4\u03b1, \u03c5\u03c0\u03cc \u03b4\u03b9\u03b5\u03c1\u03b5\u03cd\u03bd\u03b7\u03c3\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf \u03c1\u03cc\u03bb\u03bf\u03c2 \u03c4\u03c9\u03bd DAMPs \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03b8\u03bd\u03ae\u03c3\u03ba\u03c9\u03bd\u03c4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1, \u03b5\u03b9\u03c3\u03ad\u03c1\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b1 \u03b8\u03c5\u03c1\u03b5\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03ba\u03b1\u03b9 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03b9\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc MHC-II \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03c6\u03ac\u03bd\u03b5\u03b9\u03b1 \u03c4\u03c9\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c3\u03b5 CD4 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c0\u03c5\u03c1\u03bf\u03b4\u03bf\u03c4\u03ce\u03bd\u03c4\u03b1\u03c2 \u03ad\u03c4\u03c3\u03b9 \u03c4\u03b7\u03bd \u03ad\u03bd\u03b1\u03c1\u03be\u03b7 \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae\u03c2 \u03b1\u03c0\u03ac\u03bd\u03c4\u03b7\u03c3\u03b7\u03c2.<\/li>\n
                2. \u03a3\u03c4\u03bf \u03c5\u03c0\u03cc\u03b2\u03b1\u03b8\u03c1\u03bf \u03b1\u03c5\u03c4\u03cc \u03b5\u03c0\u03b9\u03b4\u03c1\u03bf\u03cd\u03bd \u03c0\u03b5\u03c1\u03b9\u03b2\u03b1\u03bb\u03bb\u03bf\u03bd\u03c4\u03b9\u03ba\u03bf\u03af \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2 \u03cc\u03c0\u03c9\u03c2 \u03c4\u03bf \u03ba\u03ac\u03c0\u03bd\u03b9\u03c3\u03bc\u03b1 \u03ae \u03c4\u03bf \u03b9\u03ce\u03b4\u03b9\u03bf \u03c0\u03bf\u03c5 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b1\u03bd\u03c4\u03b9\u03b3\u03bf\u03bd\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03b7\u03c2 Tg \u03ba\u03b1\u03b9 \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03bd \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af \u03c4\u03b7\u03bd \u03b1\u03c0\u03b5\u03bb\u03b5\u03c5\u03b8\u03ad\u03c1\u03c9\u03c3\u03b7 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03c9\u03bd. \u0395\u03c0\u03af\u03c3\u03b7\u03c2 \u03c1\u03cc\u03bb\u03bf \u03af\u03c3\u03c9\u03c2 \u03ad\u03c7\u03bf\u03c5\u03bd \u03ba\u03b1\u03b9 \u03bc\u03b9\u03ba\u03c1\u03bf\u03b2\u03b9\u03b1\u03ba\u03bf\u03af \u03bf\u03c1\u03b3\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03af, \u03c0\u03bf\u03c5 \u03bc\u03ad\u03c3\u03c9 \u03c4\u03bf\u03c5 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03cd \u03c4\u03b7\u03c2 \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03ae\u03c2 \u03bc\u03af\u03bc\u03b7\u03c3\u03b7\u03c2 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd \u03c4\u03bf \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03bf\u03c0\u03bb\u03bf\u03c3\u03c4\u03ac\u03c3\u03b9\u03bf. \u0391\u03ba\u03cc\u03bc\u03b1 \u03c4\u03bf stress \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bc\u03ad\u03c3\u03c9 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ce\u03bd \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03ce\u03bd (\u03ba\u03c5\u03c4\u03bf\u03ba\u03af\u03bd\u03b5\u03c2, \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 DHEAS) \u03bd\u03b1 \u03b5\u03c5\u03bf\u03b4\u03ce\u03c3\u03b5\u03b9 \u03c4\u03b7\u03bd Th2\/Th17 \u03b1\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03c9\u03c2 \u03c4\u03b7 \u03c7\u03c5\u03bc\u03b9\u03ba\u03ae \u03b1\u03bd\u03bf\u03c3\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ce\u03bd \u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03b5\u03c5\u03bd\u03bf\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7\u03bd \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7 GD. \u0395\u03c0\u03af\u03c3\u03b7\u03c2 \u03c4\u03b1 \u03bc\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c3\u03b5\u03bb\u03b7\u03bd\u03af\u03bf\u03c5 \u03af\u03c3\u03c9\u03c2 \u03c3\u03c5\u03bd\u03b5\u03b9\u03c3\u03c6\u03ad\u03c1\u03bf\u03c5\u03bd \u03c3\u03c4\u03b7\u03bd \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 \u0398\u0391, \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7\u03bd \u03b1\u03bd\u03b1\u03ba\u03ac\u03bb\u03c5\u03c8\u03b7 \u03c0\u03c9\u03c2 \u03b7 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03c3\u03b5\u03bb\u03b7\u03bd\u03af\u03bf\u03c5 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03bf\u03bd \u03b1\u03c1\u03b9\u03b8\u03bc\u03cc Tregs \u03c3\u03b5 \u03bc\u03bf\u03bd\u03c4\u03ad\u03bb\u03b1 \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03b7\u03c2 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03af\u03c4\u03b9\u03b4\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b1\u03c0\u03b5\u03bb\u03b5\u03c5\u03b8\u03ad\u03c1\u03c9\u03c3\u03b7 Th1 \u03ba\u03c5\u03c4\u03bf\u03ba\u03b9\u03bd\u03ce\u03bd \u03b1\u03c0\u03cc \u03c4\u03b1 \u03c0\u03b5\u03c1\u03b9\u03c6\u03b5\u03c1\u03b9\u03ba\u03ac \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b5\u03c5\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03bc\u03b5 \u0397\u03a4.<\/li>\n
                3. \u03a4\u03cc\u03c3\u03bf \u03c3\u03c4\u03b7 GD \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd HT \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03b5\u03af\u03c3\u03bf\u03b4\u03bf\u03c2 CD4, CD8 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03ba\u03b1\u03b9 APC \u03c3\u03c4\u03bf \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03cc \u03c0\u03b1\u03c1\u03ad\u03b3\u03c7\u03c5\u03bc\u03b1 \u03bc\u03b5 \u03c0\u03c1\u03bf\u03b5\u03be\u03ac\u03c1\u03c7\u03bf\u03bd\u03c4\u03b1 \u03c4\u03b1 \u03c0\u03c1\u03ce\u03c4\u03b1. \u0397 \u03bc\u03b5\u03c4\u03b1\u03bd\u03ac\u03c3\u03c4\u03b5\u03c5\u03c3\u03b7 \u03c4\u03c9\u03bd \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c3\u03c4\u03bf \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03ae \u03b1\u03b4\u03ad\u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03ce\u03bd \u03bc\u03b7\u03bd\u03c5\u03bc\u03ac\u03c4\u03c9\u03bd \u03c0\u03c1\u03bf\u03c3\u03ad\u03bb\u03ba\u03c5\u03c3\u03b7\u03c2. \u03a4\u03b1 \u03a4 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b1 APC \u03b5\u03b9\u03c3\u03ad\u03c1\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03ae \u03c9\u03c2 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03ad\u03ba\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2 \u03ba\u03c5\u03c4\u03bf\u03ba\u03b9\u03bd\u03ce\u03bd \u03ba\u03b1\u03b9 \u03ac\u03bb\u03bb\u03c9\u03bd \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03c4\u03b1\u03ba\u03c4\u03b9\u03ba\u03ce\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03cc\u03bd\u03c4\u03c9\u03bd \u03c4\u03bf\u03c5 \u03b5\u03bd\u03b4\u03bf\u03b8\u03b7\u03bb\u03af\u03bf\u03c5. \u03a9\u03c2 \u03b5\u03c0\u03b1\u03ba\u03cc\u03bb\u03bf\u03c5\u03b8\u03bf, \u03c4\u03b1 \u03b5\u03b9\u03c3\u03b2\u03ac\u03bb\u03bb\u03bf\u03bd\u03c4\u03b1 \u03c3\u03c4\u03bf \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03ae APC \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03b9\u03ac\u03b6\u03bf\u03c5\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03b1 \u03c3\u03c4\u03b1 \u03a4 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1.<\/li>\n
                4. Tregs \u03ba\u03b1\u03b9 Bregs
                  \n– \u0395\u03be\u03b1\u03b9\u03c1\u03b5\u03c4\u03b9\u03ba\u03ac \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03c1\u03cc\u03bb\u03bf \u03c3\u03c4\u03b7 \u03b4\u03b9\u03b1\u03c6\u03c5\u03b3\u03ae \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03c0\u03b5\u03c1\u03b9\u03c6\u03b5\u03c1\u03b9\u03ba\u03ae \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b1\u03bd\u03bf\u03c7\u03ae \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03c0\u03c1\u03bf\u03b1\u03b3\u03c9\u03b3\u03ae \u03ae \u03b1\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03ae \u03c4\u03c9\u03bd \u03b4\u03cd\u03bf \u03b5\u03c0\u03cc\u03bc\u03b5\u03bd\u03c9\u03bd \u03c3\u03c4\u03b1\u03b4\u03af\u03c9\u03bd \u03ad\u03c7\u03b5\u03b9 \u03b7 \u03b4\u03c1\u03ac\u03c3\u03b7 \u03c4\u03c9\u03bd Tregs \u03c0\u03bf\u03c5 \u03b4\u03b9\u03b7\u03b8\u03bf\u03cd\u03bd \u03c4\u03bf \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03ae \u03ba\u03b1\u03b9 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03c5\u03bd \u0399L-10 \u03ba\u03b1\u03b9 TGF-b. \u03a1\u03cc\u03bb\u03bf\u03c2 \u03c4\u03c9\u03bd Tregs \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03b7 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03c9\u03bd \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ce\u03bd \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd (\u03a4 effectors) \u03c0\u03bf\u03c5 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03bc\u03c6\u03b1\u03bd\u03b9\u03c3\u03c4\u03bf\u03cd\u03bd. \u03a9\u03c3\u03c4\u03cc\u03c3\u03bf \u03c3\u03c4\u03b7 \u0398\u0391 \u03c4\u03b1 \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03bf\u03cd\u03bd\u03c4\u03b1 \u03a4regs \u03b5\u03af\u03bd\u03b1\u03b9 \u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03ac \u03ba\u03b1\u03b9 \u03bb\u03b9\u03b3\u03cc\u03c4\u03b5\u03c1\u03bf \u03b9\u03ba\u03b1\u03bd\u03ac \u03bd\u03b1 \u03b1\u03bd\u03b1\u03c3\u03c4\u03b5\u03af\u03bb\u03bf\u03c5\u03bd \u03c4\u03bf\u03bd \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03cc \u03c4\u03c9\u03bd T \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ce\u03bd \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd (\u03a4 effectors) \u03bc\u03b5 \u03c4\u03b5\u03bb\u03b9\u03ba\u03cc \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03b7\u03bd \u03b1\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1 \u03b1\u03bd\u03bf\u03c7\u03ae\u03c2 \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03c4\u03c9\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03c9\u03bd \u03ba\u03b1\u03b9 \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7 \u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd (\u03c0.\u03c7 anti-TSHR). \u0397 \u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03ae \u03b7 \u03c0\u03b9\u03b8\u03b1\u03bd\u03ae \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b1\u03c1\u03b9\u03b8\u03bc\u03bf\u03cd \u03c4\u03c9\u03bd Tregs \u03c3\u03c4\u03b7 \u0398\u0391 \u03af\u03c3\u03c9\u03c2 \u03bf\u03c6\u03b5\u03af\u03bb\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae IFN-a \u03b1\u03c0\u03cc \u03c4\u03b1 APC (\u03b4\u03b5\u03bd\u03b4\u03c1\u03b9\u03c4\u03b9\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1) \u03c3\u03c4\u03b7 GD. \u03a3\u03c4\u03bf \u03c3\u03c4\u03ac\u03b4\u03b9\u03bf \u03b1\u03c5\u03c4\u03cc, \u03c4\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03b7\u03c2 \u201c\u03bc\u03ac\u03c7\u03b7\u03c2\u201d \u03c4\u03c9\u03bd Tregs \u03bc\u03b5 \u03c4\u03b1 T effectors (\u03a4h1, Th2 \u03ae Th17) \u03b8\u03b1 \u03ba\u03b1\u03b8\u03bf\u03c1\u03af\u03c3\u03b5\u03b9 \u03c4\u03b7 \u03b4\u03b9\u03ae\u03b8\u03b7\u03c3\u03b7 \u03ae \u03cc\u03c7\u03b9 \u03c4\u03bf\u03c5 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03bf\u03cd\u03c2 \u03b1\u03c0\u03cc \u03ac\u03bb\u03bb\u03bf\u03c4\u03b5 \u03bc\u03b5\u03b3\u03ac\u03bb\u03bf \u03ba\u03b1\u03b9 \u03ac\u03bb\u03bb\u03bf\u03c4\u03b5 \u03bc\u03b9\u03ba\u03c1\u03cc\u03c4\u03b5\u03c1\u03bf \u03b1\u03c1\u03b9\u03b8\u03bc\u03cc \u0392 \u03ba\u03b1\u03b9 \u03a4 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd.
                  \n– \u03a4\u03b5\u03bb\u03b5\u03c5\u03c4\u03b1\u03af\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03b1\u03bd\u03b1\u03b4\u03b5\u03b9\u03c7\u03b8\u03b5\u03af \u03ba\u03b1\u03b9 \u03bf \u03c1\u03cc\u03bb\u03bf\u03c2 \u03c4\u03c9\u03bd Bregs \u03c3\u03c4\u03b7 \u0398\u0391 \u03bb\u03cc\u03b3\u03c9 \u03c4\u03b7\u03c2 \u03b1\u03bd\u03bf\u03c3\u03bf\u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03b1\u03bb\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03b4\u03c1\u03ac\u03c3\u03b7\u03c2 \u03c3\u03c4\u03bf\u03bd \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03cc \u03c4\u03c9\u03bd CD4 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03a4\u039dF-a, \u0399FN-\u03b3 \u03b1\u03c0\u03cc \u03b1\u03c5\u03c4\u03ac. \u03a3\u03c4\u03b7 GD, \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03ac \u03c4\u03bf\u03c5\u03c2 \u03ba\u03b1\u03b9 \u03b7 \u03b9\u03ba\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03ac \u03c4\u03bf\u03c5\u03c2 \u03bd\u03b1 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03c5\u03bd \u03c4\u03bf\u03bd \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03cc \u03c4\u03c9\u03bd CD4 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03b1.<\/li>\n
                5. \u03a4\u03bf \u03b5\u03c0\u03cc\u03bc\u03b5\u03bd\u03bf \u03c3\u03c4\u03ac\u03b4\u03b9\u03bf \u03c3\u03c4\u03b7\u03bd \u03b1\u03b9\u03c4\u03b9\u03bf\u03c0\u03b1\u03b8\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 \u0398\u0391 \u03ad\u03c7\u03b5\u03b9 \u03bd\u03b1 \u03ba\u03ac\u03bd\u03b5\u03b9 \u03bc\u03b5 \u03c4\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03b7\u03c2 \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ce\u03bd \u03ba\u03b1\u03b9 \u03c0\u03b5\u03c1\u03b9\u03b2\u03b1\u03bb\u03bb\u03bf\u03bd\u03c4\u03b9\u03ba\u03ce\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03cc\u03bd\u03c4\u03c9\u03bd \u03c3\u03c4\u03b7\u03bd \u03b1\u03bd\u03c4\u03b9\u03b3\u03bf\u03bd\u03bf\u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1\u03c3\u03b7 \u03b1\u03bd\u03bf\u03c3\u03bf\u03b3\u03bf\u03bd\u03b9\u03ba\u03ce\u03bd \u03b5\u03c0\u03b9\u03c4\u03cc\u03c0\u03c9\u03bd \u03c4\u03c9\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03c9\u03bd (\u03c0.\u03c7 Tg) \u03b1\u03c0\u03cc \u03c4\u03b1 APC \u03c3\u03c4\u03b1 \u03b5\u03bd\u03b4\u03bf\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ac CD4 \u03b2\u03bf\u03b7\u03b8\u03b7\u03c4\u03b9\u03ba\u03ac \u03a4 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1. \u039c\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c3\u03b5 \u03bc\u03bf\u03bd\u03c4\u03ad\u03bb\u03b1 \u03c0\u03bf\u03bd\u03c4\u03b9\u03ba\u03ce\u03bd \u03ba\u03b1\u03b9 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u0398\u0391 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b4\u03b5\u03af\u03be\u03b5\u03b9 \u03c0\u03c9\u03c2 \u03c4\u03b1 CD4 \u03a4 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1, \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03bf \u03b5\u03af\u03b4\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b4\u03b9\u03b5\u03b3\u03b5\u03c1\u03c4\u03b9\u03ba\u03bf\u03cd \u03bc\u03bf\u03c1\u03af\u03bf\u03c5 (\u03927.1, \u03927.2, CTLA-4) \u03ba\u03b1\u03b9 \u03c4\u03b9\u03c2 \u03ba\u03c5\u03c4\u03bf\u03ba\u03af\u03bd\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03b4\u03ad\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b1 APC (\u03ae \u03c4\u03b1 \u03b8\u03c5\u03c1\u03b5\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c0\u03bf\u03c5 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03b4\u03c1\u03bf\u03c5\u03bd \u03c9\u03c2 APC), \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03bf\u03cd\u03bd \u03c3\u03b5 Th1, \u03a4h2 \u03ae Th17. \u03a3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03b7 \u03b1\u03bd\u03b5\u03cd\u03c1\u03b5\u03c3\u03b7 CD8 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03c4\u03bf\u03be\u03b9\u03ba\u03ce\u03bd \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03b1\u03bd\u03c4\u03b9\u03b3\u03bf\u03bd\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03b3\u03b9\u03b1 Tg\/TPO \u03c3\u03c4\u03bf \u03c0\u03b5\u03c1\u03b9\u03c6\u03b5\u03c1\u03b9\u03ba\u03cc \u03b1\u03af\u03bc\u03b1 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03c3\u03b5 \u03b1\u03c1\u03c7\u03b9\u03ba\u03cc \u03c3\u03c4\u03ac\u03b4\u03b9\u03bf \u0397\u03a4.<\/li>\n
                6. \u03a3\u03c4\u03b7 \u03c3\u03c5\u03bd\u03ad\u03c7\u03b5\u03b9\u03b1 \u03c4\u03b1 CD4 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 (\u03a4h1 \u03ae Th2 \u03ae Th17) \u03c0\u03bf\u03c5 \u03b4\u03b9\u03ad\u03c6\u03c5\u03b3\u03b1\u03bd \u03c4\u03b7\u03c2 \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03bf\u03c7\u03ae\u03c2 (\u03a4 effectors) \u03b4\u03b9\u03b7\u03b8\u03bf\u03cd\u03bd \u03c4\u03bf \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03ae \u03b1\u03b4\u03ad\u03bd\u03b1 \u03bc\u03b5 \u03c0\u03c1\u03bf\u03b5\u03be\u03ac\u03c1\u03c7\u03bf\u03bd\u03c4\u03b1 \u03c4\u03b1 \u03a4h1\/Th17 \u03c3\u03c4\u03b7\u03bd \u0397\u03a4 \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03a4h2 \u03c3\u03c4\u03b7\u03bd GD. N\u03b5\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03b1\u03bd\u03b1\u03b4\u03b5\u03b9\u03ba\u03bd\u03cd\u03bf\u03c5\u03bd \u03c4\u03bf\u03bd \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc \u03c1\u03cc\u03bb\u03bf \u03ba\u03b1\u03b9 \u03c4\u03c9\u03bd Th1 \u03c3\u03c4\u03b7 GD.
                  \n– \u03a3\u03c4\u03b7\u03bd \u0397\u03a4, \u03c4\u03b1 APC \u03b5\u03ba\u03c6\u03c1\u03ac\u03b6\u03bf\u03c5\u03bd \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 B7.1 \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03bd\u03b1 \u03c0\u03c1\u03bf\u03c3\u03c6\u03ad\u03c1\u03bf\u03c5\u03bd \u03c3\u03c4\u03b1- \u03b4\u03b9\u03b7\u03b8\u03bf\u03cd\u03bd\u03c4\u03b1 \u03c4\u03bf \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03ae- \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c3\u03c5\u03bd\u03b4\u03b9\u03b5\u03b3\u03b5\u03c1\u03c4\u03b9\u03ba\u03cc \u03c3\u03ae\u03bc\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 Th1 \u03ba\u03c5\u03c4\u03bf\u03ba\u03b9\u03bd\u03ce\u03bd. \u0391\u03bd\u03c4\u03af\u03b8\u03b5\u03c4\u03b1 \u03c3\u03c4\u03b7 GD \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 Th2 \u03b1\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7 \u03c9\u03c2 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03b7\u03c2 B7.2 \u03c3\u03c5\u03bd\u03b4\u03b9\u03ad\u03b3\u03b5\u03c1\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 Th2 \u03ba\u03c5\u03c4\u03bf\u03ba\u03b9\u03bd\u03ce\u03bd. \u03a6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c0\u03c9\u03c2 \u03c3\u03c4\u03b7 GD, \u03bf\u03b9 Th2 \u03ba\u03c5\u03c4\u03bf\u03ba\u03af\u03bd\u03b5\u03c2 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03bc\u03b5\u03c4\u03b1\u03b2\u03ac\u03bb\u03bb\u03bf\u03c5\u03bd \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 MHC-II \u03c3\u03c4\u03b1 \u03b8\u03c5\u03c1\u03b5\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b5\u03bd\u03b9\u03c3\u03c7\u03cd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1\u03c3\u03b7 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03c9\u03bd (TSH-R) \u03b1\u03c0\u03cc \u03c4\u03b1 \u03b8\u03c5\u03c1\u03b5\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c3\u03c4\u03b1 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1. \u0391\u03be\u03af\u03b6\u03b5\u03b9 \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b7\u03b8\u03b5\u03af \u03c0\u03c9\u03c2 \u03cc\u03c4\u03b1\u03bd \u03c4\u03b1 \u03b8\u03c5\u03c1\u03b5\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b4\u03b9\u03b5\u03b3\u03b5\u03c1\u03b8\u03bf\u03cd\u03bd \u03b1\u03c0\u03cc IFN-\u03b3 (Th1) \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03ba\u03c5\u03c4\u03bf\u03ba\u03af\u03bd\u03b7 CXCL10 (Interferon gamma-induced protein 10 \u03ae \u0399P10) \u03c0\u03bf\u03c5 \u03c3\u03c4\u03c1\u03b1\u03c4\u03bf\u03bb\u03bf\u03b3\u03b5\u03af Th1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c4\u03b1 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03c5\u03bd CXCR3 (\u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03c4\u03b7\u03c2 CXCL10) \u03ba\u03b1\u03b9 IFN-\u03b3 \u03bf\u03b4\u03b7\u03b3\u03ce\u03bd\u03c4\u03b1\u03c2 \u03ad\u03c4\u03c3\u03b9 \u03c3\u03b5 \u03c6\u03b1\u03cd\u03bb\u03bf \u03ba\u03cd\u03ba\u03bb\u03bf.
                  \n– T\u03b1 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03c9\u03bd Th22 \u03ba\u03b1\u03b9 \u03a4h17 \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03ad\u03c7\u03bf\u03c5\u03bd \u03b5\u03bc\u03c0\u03bb\u03b1\u03ba\u03b5\u03af \u03c3\u03c4\u03b7\u03bd \u03b1\u03b9\u03c4\u03b9\u03bf\u03c0\u03b1\u03b8\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 HT. \u0397 \u03a4SLP \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03ac\u03b3\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u0391PC \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03ae\u03c3\u03b5\u03b9 \u03c4\u03b1 CD4 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c0\u03c1\u03bf\u03c2 \u03c4\u03b7\u03bd Th2 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03a4h17 \u03ba\u03b1\u03c4\u03b5\u03cd\u03b8\u03c5\u03bd\u03c3\u03b7. \u03a3\u03c4\u03b7\u03bd GD \u03c4\u03b1 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 CCL20 \u03ba\u03b1\u03b9 OPN, \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03ac\u03b3\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b1 APC, \u03b5\u03c5\u03bf\u03b4\u03ce\u03bd\u03bf\u03c5\u03bd \u03c4\u03b7 \u03bc\u03b5\u03c4\u03ac\u03b4\u03bf\u03c3\u03b7 \u03c3\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c4\u03b7\u03c2 IL-17 \u03ba\u03b1\u03b9 \u03b5\u03c0\u03ac\u03b3\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd Th2 \u03b1\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7.
                  \n– \u0397 \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03b1\u03c0\u03cc \u03c4\u03b1 \u0392 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03ad\u03bd\u03b1 \u03b1\u03ba\u03cc\u03bc\u03b7 \u03b2\u03b1\u03c3\u03b9\u03ba\u03cc \u03c3\u03c4\u03ac\u03b4\u03b9\u03bf \u03c4\u03b7\u03c2 \u03b1\u03b9\u03c4\u03b9\u03bf\u03c0\u03b1\u03b8\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1\u03c2 \u03c4\u03b7\u03c2 \u0398\u0391, \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03cc\u03c3\u03bf\u03bd \u03b1\u03c6\u03bf\u03c1\u03ac \u03c3\u03c4\u03b7 GD. H \u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 CD40L \u03c0\u03bf\u03c5 \u03b5\u03ba\u03c6\u03c1\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b1 \u03a4h2 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1, \u03bb\u03cc\u03b3\u03c9 \u03c4\u03b7\u03c2 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7\u03c2 \u039fPN \u03bc\u03b5 \u03c4\u03bf\u03bd CD40 \u03c4\u03c9\u03bd \u0392 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd, \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03b5 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c4\u03b5\u03bb\u03b5\u03c5\u03c4\u03b1\u03af\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd. \u0395\u03c0\u03af\u03c3\u03b7\u03c2 \u03c4\u03b1 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03ac \u03c4\u03bf\u03c5 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1 \u0392\u0391FF, \u03c0\u03bf\u03c5 \u03b5\u03ba\u03c6\u03c1\u03ac\u03b6\u03bf\u03c5\u03bd \u03c4\u03b1 \u0392 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1, \u03c0\u03c1\u03bf\u03ac\u03b3\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03bc\u03ad\u03c3\u03c9 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03b1\u03c1\u03b9\u03b8\u03bc\u03bf\u03cd \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03c9\u03c1\u03af\u03bc\u03b1\u03bd\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd \u0392 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03c9\u03bd. \u0395\u03c0\u03b9\u03c0\u03c1\u03cc\u03c3\u03b8\u03b5\u03c4\u03b1, \u03c4\u03b1 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03c9\u03bd <\/i>Tfh \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03ad\u03c7\u03bf\u03c5\u03bd \u03c3\u03c4\u03b7 \u03c1\u03cd\u03b8\u03bc\u03b9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03bd\u03c4\u03b9\u03b3\u03bf\u03bd\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03bf\u03c3\u03af\u03b1\u03c2 \u03c4\u03c9\u03bd \u0392 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd.<\/li>\n
                7. T\u03b1 \u03a4 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac (\u03a4 effector) \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 (\u03a4h1, Th2 \u03ae Th17) \u03c0\u03bf\u03c5 \u03b8\u03b1 \u03b4\u03b9\u03b1\u03c6\u03cd\u03b3\u03bf\u03c5\u03bd \u03c4\u03b5\u03bb\u03b9\u03ba\u03ac \u03b1\u03c0\u03cc \u03c4\u03b7 \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03c4\u03b9\u03ba\u03ae \u03b4\u03c1\u03ac\u03c3\u03b7 \u03c4\u03c9\u03bd \u03a4regs \u03ba\u03b1\u03b9 \u0392regs \u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03b9\u03b4\u03c1\u03bf\u03cd\u03bd \u03bc\u03b5 \u03c4\u03b1 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c3\u03b5 \u03bc\u03b9\u03b1 \u03b4\u03b5\u03cd\u03c4\u03b5\u03c1\u03b7 \u201c\u03bc\u03ac\u03c7\u03b7 \u03b3\u03b9\u03b1 \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7\u201d. H \u03ad\u03ba\u03b2\u03b1\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bc\u03ac\u03c7\u03b7\u03c2 \u03b1\u03c5\u03c4\u03ae\u03c2 \u03b8\u03b1 \u03ba\u03b1\u03b8\u03bf\u03c1\u03af\u03c3\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c6\u03b1\u03b9\u03bd\u03bf\u03c4\u03c5\u03c0\u03b9\u03ba\u03ae \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03b7\u03c2 \u0398\u0391. \u03a3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf \u03c1\u03cc\u03bb\u03bf\u03c2 \u03c4\u03c9\u03bd \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03ce\u03bd \u03c3\u03c4\u03bf \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03cc \u03bc\u03b9\u03ba\u03c1\u03bf\u03c0\u03b5\u03c1\u03b9\u03b2\u03ac\u03bb\u03bb\u03bf\u03bd, \u03c0\u03bf\u03c5 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03b9 \u03c3\u03c5\u03bd-\u03b4\u03b9\u03b5\u03b3\u03b5\u03c1\u03c4\u03b9\u03ba\u03ac \u03bc\u03cc\u03c1\u03b9\u03b1 (\u03927.1 \u03ae \u03927.2), \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03ba\u03af\u03bd\u03b5\u03c2 (Th1, Th2 \u03ae \u03a4h17), \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03b5\u03af\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bd\u03b4\u03ad\u03c4\u03b5\u03c2 \u03b8\u03b1\u03bd\u03ac\u03c4\u03bf\u03c5 (Fas, FasL, DR-4\/DR-5, TRAIL), \u03b1\u03bd\u03c4\u03b9\u03b1\u03c0\u03bf\u03c0\u03c4\u03c9\u03c4\u03b9\u03ba\u03ac \u03bc\u03cc\u03c1\u03b9\u03b1 (Bcl-2) \u03ba\u03b1\u03b9 \u03b4\u03b9\u03b1\u03bb\u03c5\u03c4\u03ac \u03bc\u03cc\u03c1\u03b9\u03b1 (sFas, sFasL). \u03a3\u03c4\u03b7 GD \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c0\u03c9\u03c2 \u03b5\u03c0\u03b9\u03ba\u03c1\u03b1\u03c4\u03bf\u03cd\u03bd \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03af \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd, \u03af\u03c3\u03c9\u03c2 \u03bb\u03cc\u03b3\u03c9 \u03c4\u03b7\u03c2 \u03b5\u03c0\u03b9\u03ba\u03c1\u03ac\u03c4\u03b7\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd Th2 \u03ba\u03c5\u03c4\u03bf\u03ba\u03b9\u03bd\u03ce\u03bd. \u0388\u03c4\u03c3\u03b9 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 Bcl-2, \u03b5\u03bd\u03ce \u03b7 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03bc\u03bf\u03c1\u03af\u03c9\u03bd \u03cc\u03c0\u03c9\u03c2 \u03c4\u03bf FasL \u03ba\u03b1\u03b9 \u03c4\u03bf TRAIL \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03c0\u03ac\u03b3\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03c6\u03ac\u03bd\u03b5\u03b9\u03ac \u03c4\u03bf\u03c5\u03c2 \u03bc\u03b5 \u03c4\u03b5\u03bb\u03b9\u03ba\u03cc \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03ae \u03c4\u03bf\u03c5\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03c5\u03c0\u03b5\u03c1\u03af\u03c3\u03c7\u03c5\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c7\u03c5\u03bc\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03bf\u03c3\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae\u03c2 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03c0\u03bf\u03c5 \u03b4\u03b9\u03b5\u03b3\u03b5\u03af\u03c1\u03bf\u03c5\u03bd \u03c4\u03bf\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03c4\u03b7\u03c2 TSH \u03ba\u03b1\u03b9 \u03bf\u03b4\u03b7\u03b3\u03bf\u03cd\u03bd \u03c3\u03b5 \u03c5\u03c0\u03b5\u03c1\u03c0\u03bb\u03b1\u03c3\u03af\u03b1 \u03c4\u03c9\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd.<\/li>\n<\/ol>\n

                  \u03a3\u03c4\u03b7\u03bd \u0397\u03a4 \u03bf \u03b1\u03c0\u03bf\u03c0\u03c4\u03c9\u03c4\u03b9\u03ba\u03cc\u03c2 \u03b8\u03ac\u03bd\u03b1\u03c4\u03bf\u03c2 \u03c4\u03c9\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03b5\u03c0\u03ac\u03b3\u03b5\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b1\u03bd \u03b5\u03bd\u03b4\u03bf\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c0\u03bf\u03c5 \u03b5\u03ba\u03ba\u03c1\u03af\u03bd\u03bf\u03c5\u03bd \u03c4\u03bf\u03c0\u03b9\u03ba\u03ac \u03a4h1 \u03ba\u03c5\u03c4\u03bf\u03ba\u03af\u03bd\u03b5\u03c2, \u03b5\u03ba\u03c6\u03c1\u03ac\u03b6\u03bf\u03c5\u03bd FasL \u03ba\u03b1\u03b9 Bcl-2 \u03ba\u03b1\u03b9 \u03af\u03c3\u03c9\u03c2 \u03b5\u03ba\u03ba\u03c1\u03af\u03bd\u03bf\u03c5\u03bd sFasL, \u03ad\u03c1\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b5\u03c0\u03b1\u03c6\u03ae \u03bc\u03b5 \u03c4\u03bf\u03bd Fas \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03c4\u03c9\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd. \u03a4\u03b1 \u03c4\u03b5\u03bb\u03b5\u03c5\u03c4\u03b1\u03af\u03b1 \u03b5\u03ba\u03c6\u03c1\u03ac\u03b6\u03bf\u03c5\u03bd \u03bc\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03bf Bcl-2 \u03ba\u03b1\u03b9 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf Fas. \u039f\u03b9 \u03a4h1 \u03ba\u03c5\u03c4\u03bf\u03ba\u03af\u03bd\u03b5\u03c2 \u03af\u03c3\u03c9\u03c2 \u03ac\u03c1\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03bf\u03c5 Fas\/FasL \u03bc\u03bf\u03bd\u03bf\u03c0\u03b1\u03c4\u03b9\u03bf\u03cd, \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03c3\u03c4\u03b1 \u03b8\u03c5\u03c1\u03b5\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1, \u03ba\u03b1\u03b8\u03b9\u03c3\u03c4\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b1 \u03ad\u03c4\u03c3\u03b9 \u03b5\u03c5\u03ac\u03bb\u03c9\u03c4\u03b1 \u03c3\u03b5 \u03b1\u03c0\u03cc\u03c0\u03c4\u03c9\u03c3\u03b7. \u0391\u03be\u03af\u03b6\u03b5\u03b9 \u03c4\u03ad\u03bb\u03bf\u03c2 \u03bd\u03b1 \u03c3\u03b7\u03bc\u03b5\u03b9\u03c9\u03b8\u03b5\u03af \u03ba\u03b1\u03b9 \u03b7 \u03c5\u03c0\u03cc\u03b8\u03b5\u03c3\u03b7 \u03c4\u03c9\u03bd Giordano et<\/i> <\/i>al<\/i>, (175) \u03c0\u03b5\u03c1\u03af \u03c5\u03c0\u03ac\u03c1\u03be\u03b5\u03c9\u03c2 \u03b5\u03bd\u03cc\u03c2 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc \u201c\u03b1\u03b4\u03b5\u03bb\u03c6\u03bf\u03ba\u03c4\u03bf\u03bd\u03af\u03b1\u03c2\u201d \u03c4\u03c9\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c3\u03c4\u03b7\u03bd \u0397\u03a4 \u03bb\u03cc\u03b3\u03c9 \u03c4\u03b1\u03c5\u03c4\u03cc\u03c7\u03c1\u03bf\u03bd\u03b7\u03c2 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7\u03c2 Fas \u03ba\u03b1\u03b9 FasL \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03c6\u03ac\u03bd\u03b5\u03b9\u03b1 \u03c4\u03bf\u03c5\u03c2.<\/p>\n

                  \u039f\u03bb\u03bf\u03ba\u03bb\u03b7\u03c1\u03ce\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2, \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b5\u03bc\u03c6\u03b1\u03bd\u03ad\u03c2 \u03c0\u03c9\u03c2 \u03b7 \u03b1\u03b9\u03c4\u03b9\u03bf\u03c0\u03b1\u03b8\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 \u0398\u0391 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03bf\u03bb\u03c5\u03c0\u03b1\u03c1\u03b1\u03b3\u03bf\u03bd\u03c4\u03b9\u03ba\u03ae \u03bc\u03b5 \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03bf\u03cd\u03c2 \u03c3\u03c5\u03bd\u03c4\u03b5\u03bb\u03b5\u03c3\u03c4\u03ad\u03c2 \u03bd\u03b1 \u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03b9\u03b4\u03c1\u03bf\u03cd\u03bd \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03c3\u03c5\u03bd\u03b5\u03b9\u03c3\u03c6\u03ad\u03c1\u03bf\u03c5\u03bd \u03c3\u03b5 \u03c0\u03bf\u03b9\u03ba\u03af\u03bb\u03bf \u03b2\u03b1\u03b8\u03bc\u03cc \u03c3\u03c4\u03b1 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ac \u03c3\u03c4\u03ac\u03b4\u03b9\u03b1 \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5. \u0397 \u03b1\u03bd\u03ac\u03b3\u03ba\u03b7 \u03c0\u03bf\u03c3\u03bf\u03c4\u03b9\u03ba\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03c3\u03c5\u03bd\u03b5\u03b9\u03c3\u03c6\u03bf\u03c1\u03ac\u03c2 \u03c4\u03c9\u03bd \u03c0\u03c1\u03bf\u03b1\u03bd\u03b1\u03c6\u03b5\u03c1\u03b8\u03ad\u03bd\u03c4\u03c9\u03bd \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03ce\u03bd \u03c3\u03c4\u03b7\u03bd \u03ad\u03bd\u03b1\u03c1\u03be\u03b7 \u03ba\u03b1\u03b9 \u03b5\u03be\u03ad\u03bb\u03b9\u03be\u03b7 \u03c4\u03c9\u03bd \u03c3\u03c4\u03b1\u03b4\u03af\u03c9\u03bd \u03c4\u03b7\u03c2 \u0398\u0391 \u03b1\u03bd\u03b1\u03ba\u03cd\u03c0\u03c4\u03b5\u03b9 \u03c9\u03c2 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae. \u0391\u03ba\u03cc\u03bc\u03b1 \u03bf \u03b1\u03ba\u03c1\u03b9\u03b2\u03ae\u03c2 \u03c1\u03cc\u03bb\u03bf\u03c2 \u03c4\u03c9\u03bd \u03bd\u03ad\u03c9\u03bd \u03bc\u03bf\u03c1\u03af\u03c9\u03bd \u03c0\u03bf\u03c5 \u03c6\u03b1\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03b5\u03bc\u03c0\u03bb\u03ad\u03ba\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03c0\u03b1\u03b8\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 \u0398\u0391 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c3\u03b1\u03c6\u03ae\u03bd\u03b9\u03c3\u03b7. \u03a4\u03ad\u03bb\u03bf\u03c2 \u03c4\u03bf \u03bc\u03b5\u03b3\u03ac\u03bb\u03bf \u03b5\u03c1\u03ce\u03c4\u03b7\u03bc\u03b1 \u03b3\u03b9\u03b1\u03c4\u03af \u03ba\u03b1\u03b9 \u03c0\u03cc\u03c4\u03b5 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03b5\u03b9 \u03b1\u03ba\u03cc\u03bc\u03b1 \u03b1\u03bd\u03b1\u03c0\u03ac\u03bd\u03c4\u03b7\u03c4\u03bf.<\/p>\n

                  \n

                  \"10.10-figure4\"<\/p>\n

                  \u0395\u03b9\u03ba\u03cc\u03bd\u03b1 4.<\/strong><\/em> \u03a3\u03cd\u03bd\u03bf\u03c8\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03b9\u03c4\u03b9\u03bf\u03c0\u03b1\u03b8\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03c2\u03b1 \u03c4\u03b7\u03c2 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae\u03c2 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03bf\u03c3\u03af\u03b1\u03c2.<\/p>\n

                  \n

                  \u0392\u03b9\u03b2\u03bb\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1<\/h4>\n

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                  \n

                  Created: October 25, 2014
                  \nLast update: October 25, 2014<\/p>\n","protected":false},"excerpt":{"rendered":"

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