\n\u039c\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03c4\u03bf\u03c5 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03c4\u03b7\u03c2 TSH<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n3. \u0394\u03b9\u03b1\u03c6\u03bf\u03c1\u03b9\u03ba\u03ae \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7<\/b><\/h4>\n\u0395\u03af\u03bd\u03b1\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03bd\u03b1 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bc\u03b5 \u03c5\u03c0\u03cc\u03c8\u03b7 \u03bc\u03b1\u03c2 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03c4\u03c1\u03bf\u03c5\u03c2 \u03c0\u03bf\u03c5 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bf\u03b4\u03b7\u03b3\u03ae\u03c3\u03bf\u03c5\u03bd \u03c3\u03b5 \u03b5\u03bb\u03b1\u03c6\u03c1\u03ac \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c4\u03b9\u03bc\u03ce\u03bd \u03c4\u03b7\u03c2 TSH \u03c7\u03c9\u03c1\u03af\u03c2 \u03b1\u03c5\u03c4\u03cc \u03bd\u03b1 \u03c3\u03c5\u03bd\u03b5\u03c0\u03ac\u03b3\u03b5\u03c4\u03b1\u03b9 \u03b5\u03be\u03b5\u03bb\u03b9\u03c3\u03c3\u03cc\u03bc\u03b5\u03bd\u03b7 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03cc\u03c0\u03c9\u03c2:<\/p>\n 3.1. \u039a\u03b1\u03c4\u03b1\u03bd\u03bf\u03bc\u03ae \u03c4\u03b7\u03c2 <\/b>TSH<\/b> \u03c3\u03c4\u03bf \u03b3\u03b5\u03bd\u03b9\u03ba\u03cc \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03cc<\/b><\/h5>\n\u03a3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03b4\u03b7\u03bc\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 NHANES I I I (National Health and Nutrition Examination Survey) \u03c0\u03bf\u03c5 \u03b4\u03b9\u03b5\u03bd\u03b5\u03c1\u03b3\u03ae\u03b8\u03b7\u03ba\u03b5 \u03c3\u03c4\u03b9\u03c2 \u0397\u03a0\u0391 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd 1988-1994, \u03c3\u03b5 \u03b4\u03b5\u03af\u03b3\u03bc\u03b1 17335 \u03b1\u03c4\u03cc\u03bc\u03c9\u03bd (\u03c3\u03c4\u03b1\u03c4\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03b1\u03bd\u03c4\u03b9\u03c0\u03c1\u03bf\u03c3\u03ce\u03c0\u03b5\u03c5\u03b5 200×106<\/sup> \u03ac\u03c4\u03bf\u03bc\u03b1 \u03b7\u03bb\u03b9\u03ba\u03af\u03b1\u03c2 \u03ac\u03bd\u03c9 \u03c4\u03c9\u03bd 12 \u03b5\u03c4\u03ce\u03bd) \u03b7 \u03b4\u03b9\u03ac\u03bc\u03b5\u03c3\u03b7 \u03c4\u03b9\u03bc\u03ae \u03c4\u03b7\u03c2 TSH \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03b1\u03bd\u03ce\u03c4\u03b5\u03c1\u03b1 \u03cc\u03c1\u03b9\u03b1 \u03b1\u03bd\u03b1\u03c6\u03bf\u03c1\u03ac\u03c2 \u03c4\u03b7\u03c2, \u03c4\u03cc\u03c3\u03bf \u03c3\u03c4\u03bf\u03bd \u03b5\u03bb\u03b5\u03cd\u03b8\u03b5\u03c1\u03bf \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5 \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03cc \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03c3\u03c4\u03bf\u03bd \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03cc \u03b1\u03bd\u03b1\u03c6\u03bf\u03c1\u03ac\u03c2, \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03b9\u03ac\u03b6\u03bf\u03c5\u03bd \u03c3\u03c4\u03b1\u03b4\u03b9\u03b1\u03ba\u03ae \u03ac\u03bd\u03bf\u03b4\u03bf \u03bc\u03b5 \u03c4\u03b7\u03bd \u03c0\u03c1\u03cc\u03bf\u03b4\u03bf \u03c4\u03b7\u03c2 \u03b7\u03bb\u03b9\u03ba\u03af\u03b1\u03c2 (\u03a0\u03af\u03bd\u03b1\u03ba\u03b1\u03c2 2<\/b>).<\/p>\n\u03a0\u03af\u03bd\u03b1\u03ba\u03b1\u03c2 2. <\/b>\u0395\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 TSH \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03b9\u03c2 \u03c5\u03c0\u03bf\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03b7\u03bb\u03b9\u03ba\u03b9\u03ce\u03bd, \u03c3\u03cd\u03bc\u03c6\u03c9\u03bd\u03b1 \u03bc\u03b5 \u03c4\u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 NHANES III [\u03bc\u03b5\u03c4\u03b1\u03c6\u03c1\u03b1\u03c3\u03bc\u03ad\u03bd\u03bf \u03b1\u03c0\u03cc Hollowell JG et al (15)].<\/p>\n\n\n\n| \u00a0<\/span><\/td>\n | \n N<\/b><\/span><\/p>\n<\/td>\n | \n TSH<\/b> <\/b>(mU\/L)<\/b><\/span><\/p>\nmedian<\/b><\/span><\/p>\n<\/td>\n | \n P 2,5 \u2013 P 97,5<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n\n| 1. \u03a3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03cc\u03c2 \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03cc\u03c2 >12 \u03b5\u03c4\u03ce\u03bd<\/td>\n | \n 17353<\/p>\n<\/td>\n | \n 1,49<\/p>\n<\/td>\n | \n 0,33-5,80<\/p>\n<\/td>\n<\/tr>\n | \n| 2. \u0395\u03bb\u03b5\u03cd\u03b8\u03b5\u03c1\u03bf\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5 \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03cc\u03c2 (1)<\/td>\n | \n 16533<\/p>\n<\/td>\n | \n 1,49<\/p>\n<\/td>\n | \n 0,44-5,52<\/p>\n<\/td>\n<\/tr>\n | \n| 3. \u03a0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03cc\u03c2 \u03b1\u03bd\u03b1\u03c6\u03bf\u03c1\u03ac\u03c2 (2)<\/td>\n | \n 13344<\/p>\n<\/td>\n | \n 1,39<\/p>\n<\/td>\n | \n 0,45-4,12<\/p>\n<\/td>\n<\/tr>\n | \n| \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 12 – 19 \u03b5\u03c4\u03ce\u03bd<\/td>\n | <\/td>\n | \n 1,35<\/p>\n<\/td>\n | \n 0,46-4,07<\/p>\n<\/td>\n<\/tr>\n | \n| \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 20 – 29 \u03b5\u03c4\u03ce\u03bd<\/td>\n | <\/td>\n | \n 1,26<\/p>\n<\/td>\n | \n 0,40-3,56<\/p>\n<\/td>\n<\/tr>\n | \n| \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 30 – 39 \u03b5\u03c4\u03ce\u03bd<\/td>\n | <\/td>\n | \n 1,29<\/p>\n<\/td>\n | \n 0,42-3,69<\/p>\n<\/td>\n<\/tr>\n | \n| \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 40 – 49 \u03b5\u03c4\u03ce\u03bd<\/td>\n | <\/td>\n | \n 1,40<\/p>\n<\/td>\n | \n 0,50-3,82<\/p>\n<\/td>\n<\/tr>\n | \n| \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 50 – 59 \u03b5\u03c4\u03ce\u03bd<\/td>\n | <\/td>\n | \n 1,50<\/p>\n<\/td>\n | \n 0,52-4,03<\/p>\n<\/td>\n<\/tr>\n | \n| \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 60 – 69 \u03b5\u03c4\u03ce\u03bd<\/td>\n | <\/td>\n | \n 1,67<\/p>\n<\/td>\n | \n 0,49-4,33<\/p>\n<\/td>\n<\/tr>\n | \n| \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 70 – 79 \u03b5\u03c4\u03ce\u03bd<\/td>\n | <\/td>\n | \n 1,76<\/p>\n<\/td>\n | \n 0,45-5,90<\/p>\n<\/td>\n<\/tr>\n | \n| \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 > 80 \u03b5\u03c4\u03ce\u03bd<\/td>\n | <\/td>\n | \n 1,90<\/p>\n<\/td>\n | \n 0,33-7,50<\/p>\n<\/td>\n<\/tr>\n | \n| (1) \u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03b9\u03c3\u03bc\u03cc\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03c0\u03bf\u03c5 \u03b1\u03bd\u03ad\u03c6\u03b5\u03c1\u03b1\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae \u03bd\u03cc\u03c3\u03bf, \u03b2\u03c1\u03bf\u03b3\u03c7\u03bf\u03ba\u03ae\u03bb\u03b7 \u03ae \u03bb\u03ac\u03bc\u03b2\u03b1\u03bd\u03b1\u03bd \u03ae\u03b4\u03b7 \u03b1\u03b3\u03c9\u03b3\u03ae(2) \u03c0\u03b5\u03c1\u03b1\u03b9\u03c4\u03ad\u03c1\u03c9 \u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03b9\u03c3\u03bc\u03cc\u03c2 \u03bb\u03cc\u03b3\u03c9 \u03ba\u03cd\u03b7\u03c3\u03b7\u03c2, \u03bb\u03ae\u03c8\u03b7\u03c2 \u03bf\u03b9\u03c3\u03c4\u03c1\u03bf\u03b3\u03cc\u03bd\u03c9\u03bd, \u03b1\u03bd\u03b4\u03c1\u03bf\u03b3\u03cc\u03bd\u03c9\u03bd, \u03bb\u03b9\u03b8\u03af\u03bf\u03c5, \u03b8\u03b5\u03c4\u03b9\u03ba\u03ce\u03bd\u00a0 \u03b1\u03bd\u03c4\u03b9\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd, \u03c7\u03b7\u03bc\u03b9\u03ba\u03bf\u03cd \u03c5\u03c0\u03bf- \u03ba\u03b1\u03b9 \u03c5\u03c0\u03b5\u03c1\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03c3\u03bc\u03bf\u03cd<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n \u0395\u03c0\u03af\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03bf \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03c4\u03c9\u03bd \u03b1\u03c4\u03cc\u03bc\u03c9\u03bd \u03c3\u03b5 \u03cc\u03bb\u03b5\u03c2 \u03c4\u03b9\u03c2 \u03c5\u03c0\u03bf\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03b5\u03af\u03c7\u03b1\u03bd \u03c4\u03b9\u03bc\u03ae TSH \u03ac\u03bd\u03c9 \u03c4\u03c9\u03bd 4,5 mU\/L \u03c0\u03bf\u03c5 \u03b8\u03b5\u03c9\u03c1\u03bf\u03cd\u03bd\u03c4\u03b1\u03bd \u03b3\u03b5\u03bd\u03b9\u03ba\u03ac \u03c9\u03c2 \u03bf\u03b9 \u03b1\u03bd\u03ce\u03c4\u03b5\u03c1\u03b5\u03c2 \u03c4\u03b9\u03bc\u03ad\u03c2 \u03b1\u03bd\u03b1\u03c6\u03bf\u03c1\u03ac\u03c2 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1\u03b6\u03b5 \u03c0\u03c1\u03bf\u03ca\u03bf\u03cd\u03c3\u03b1 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 (\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 1<\/b>).<\/p>\n
\n ![\"10.17image1\"](\"https:\/\/e-endocrinology.gr\/wp-content\/uploads\/2015\/02\/10.17image1.jpg\") <\/p>\n
\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 1. <\/b>\u03a0\u03bf\u03c3\u03bf\u03c3\u03c4\u03ac \u03b1\u03c4\u03cc\u03bc\u03c9\u03bd \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b7\u03bb\u03b9\u03ba\u03af\u03b1, \u03c0\u03bf\u03c5 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c4\u03b9\u03bc\u03ae TSH > 4,5 mU\/L, \u03c3\u03cd\u03bc\u03c6\u03c9\u03bd\u03b1 \u03bc\u03b5 \u03c4\u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 NHANES III [Hollowell et al (15)].<\/p>\n
\n \u0395\u03af\u03bd\u03b1\u03b9 \u03b5\u03bd\u03b4\u03b9\u03b1\u03c6\u03ad\u03c1\u03bf\u03bd \u03cc\u03c4\u03b9 \u03bf\u03b9 \u03b3\u03c5\u03bd\u03b1\u03af\u03ba\u03b5\u03c2 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03c4\u03b9\u03bc\u03ad\u03c2 TSH \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5\u03c2 \u03ac\u03bd\u03b4\u03c1\u03b5\u03c2 \u03c3\u03b5 \u03cc\u03bb\u03b5\u03c2 \u03c3\u03c7\u03b5\u03b4\u03cc\u03bd \u03c4\u03b9\u03c2 \u03b7\u03bb\u03b9\u03ba\u03b9\u03b1\u03ba\u03ad\u03c2 \u03c5\u03c0\u03bf\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03ac\u03bd\u03c9 \u03c4\u03c9\u03bd 30 \u03b5\u03c4\u03ce\u03bd (\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 2<\/b>). \u0397 \u03ba\u03b1\u03c4\u03b1\u03bd\u03bf\u03bc\u03ae \u03c4\u03cc\u03c3\u03bf \u03c4\u03c9\u03bd \u03b1\u03c1\u03b9\u03b8\u03bc\u03b7\u03c4\u03b9\u03ba\u03ce\u03bd, \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03c4\u03c9\u03bd \u03bb\u03bf\u03b3\u03b1\u03c1\u03b9\u03b8\u03bc\u03b9\u03ba\u03ce\u03bd \u03c4\u03b9\u03bc\u03ce\u03bd \u03c4\u03b7\u03c2 TSH \u03c3\u03c4\u03bf\u03bd \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03cc \u03b1\u03bd\u03b1\u03c6\u03bf\u03c1\u03ac\u03c2 (\u03c0.\u03c7 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03c7\u03c9\u03c1\u03af\u03c2 \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03bf\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1\u03c2, \u03bb\u03ae\u03c8\u03b7\u03c2 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c7\u03c9\u03c1\u03af\u03c2 \u03b1\u03bd\u03c4\u03b9\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1) \u03c3\u03c4\u03b7 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03ae\u03c4\u03b1\u03bd \u03bc\u03b7 \u03ba\u03b1\u03bd\u03bf\u03bd\u03b9\u03ba\u03ae (\u03ba\u03c9\u03b4\u03c9\u03bd\u03bf\u03b5\u03b9\u03b4\u03ae\u03c2) \u03bc\u03b5 \u03b1\u03c0\u03cc\u03ba\u03bb\u03b9\u03c3\u03b7 \u03c3\u03c4\u03b1 \u03b1\u03bd\u03ce\u03c4\u03b5\u03c1\u03b1 \u03cc\u03c1\u03b9\u03b1 \u03c4\u03b9\u03bc\u03ce\u03bd \u03c4\u03b7\u03c2 TSH (\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 3<\/b>). \u03a0\u03b1\u03c1\u03cc\u03bc\u03bf\u03b9\u03b1 \u03b1\u03c0\u03cc\u03ba\u03bb\u03b9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03ba\u03b1\u03bc\u03c0\u03c5\u03bb\u03ce\u03bd \u03ba\u03b1\u03c4\u03b1\u03bd\u03bf\u03bc\u03ae\u03c2 \u03c4\u03b7\u03c2 TSH \u03cc\u03c3\u03bf \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03b7\u03bb\u03b9\u03ba\u03af\u03b1 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03bd\u03b5\u03cc\u03c4\u03b5\u03c1\u03b7 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03c9\u03bd \u03c4\u03b7\u03c2 \u03af\u03b4\u03b9\u03b1\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7\u03c2 (\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 4<\/b>).<\/p>\n
\n ![\"10.17image2\"](\"https:\/\/e-endocrinology.gr\/wp-content\/uploads\/2015\/02\/10.17image2.jpg\") <\/p>\n
\u00a0<\/b><\/p>\n \u0395\u03b9\u03ba\u03cc\u03bd\u03b1 2. <\/b>\u0395\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 TSH \u03c3\u03b5 \u03b5\u03bb\u03b5\u03cd\u03b8\u03b5\u03c1\u03bf \u03bd\u03cc\u03c3\u03bf\u03c5 \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03cc, \u03bc\u03b5 \u03ae \u03c7\u03c9\u03c1\u03af\u03c2 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03bf \u03c6\u03cd\u03bb\u03bf, \u03c3\u03cd\u03bc\u03c6\u03c9\u03bd\u03b1 \u03bc\u03b5 \u03c4\u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 NHANES \u0399\u0399\u0399 [Hollowell et al (15)].<\/p>\n
\n ![\"10.17image3\"](\"https:\/\/e-endocrinology.gr\/wp-content\/uploads\/2015\/02\/10.17image3.jpg\") <\/p>\n
\n \u0395\u03b9\u03ba\u03cc\u03bd\u03b1 3. <\/b>\u03a0\u03bf\u03c3\u03bf\u03c3\u03c4\u03b9\u03b1\u03af\u03b1 \u03ba\u03b1\u03c4\u03b1\u03bd\u03bf\u03bc\u03ae \u03c4\u03c9\u03bd \u03b1\u03c1\u03b9\u03b8\u03bc\u03b7\u03c4\u03b9\u03ba\u03ce\u03bd (\u03b1) \u03ba\u03b1\u03b9 \u03bb\u03bf\u03b3\u03b1\u03c1\u03b9\u03b8\u03bc\u03b9\u03ba\u03ce\u03bd (\u03b2)\u00a0 \u03c4\u03b9\u03bc\u03ce\u03bd \u03c4\u03b7\u03c2 TSH \u03c3\u03cd\u03c6\u03c9\u03bd\u03b1 \u03bc\u03b5 \u03c4\u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 NHANES III [Hollowell et al (15)].<\/p>\n
\n<\/div>\n![\"10.17image4\"](\"https:\/\/e-endocrinology.gr\/wp-content\/uploads\/2015\/02\/10.17image4.jpg\") <\/div>\n \u00a0<\/b><\/p>\n \u0395\u03b9\u03ba\u03cc\u03bd\u03b1 4.<\/b> \u03a0\u03bf\u03c3\u03bf\u03c3\u03c4\u03b9\u03b1\u03af\u03b1 \u03ba\u03b1\u03c4\u03b1\u03bd\u03bf\u03bc\u03ae \u03c4\u03c9\u03bd \u03c4\u03b9\u03bc\u03ce\u03bd \u03c4\u03b7\u03c2 TSH \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b7\u03bb\u03b9\u03ba\u03af\u03b1 \u03c3\u03c4\u03b7\u03bd \u03c0\u03b1\u03bb\u03b1\u03b9\u03cc\u03c4\u03b5\u03c1\u03b7 \u03b5\u03ba\u03b4\u03bf\u03c7\u03ae \u03c4\u03b7\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7\u03c2 NHANES III (15) \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03bd\u03b5\u03cc\u03c4\u03b5\u03c1\u03b7 (128). NHANES III vs NHANES 99-02\u00a0 (A) \u03b5\u03bb\u03b5\u03cd\u03b8\u03b5\u03c1\u03bf\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5 \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03cc\u03c2 (\u0392) \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03cc\u03c2 \u03b1\u03bd\u03b1\u03c6\u03bf\u03c1\u03ac \u039c\u03b5\u03c4\u03b1\u03c6\u03c1\u03b1\u03c3\u03bc\u03ad\u03bd\u03bf \u03b1\u03c0\u03cc Hollowell et al (15), Surks et al (128)<\/p>\n
\n \u03a4\u03b1 \u03b5\u03c5\u03c1\u03ae\u03bc\u03b1\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7\u03c2 NHANES III \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5 \u03c4\u03b7 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03bf\u03c5 \u03a5\u03a5\u0398 \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c0\u03c9\u03c2 \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03b9\u03ce\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03b1\u03c0\u03cc \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03bf\u03b9\u03c7\u03b1 \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1 \u03ac\u03bb\u03bb\u03c9\u03bd \u03bc\u03b5\u03bb\u03b5\u03c4\u03ce\u03bd \u03b1\u03c0\u03cc \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c7\u03ce\u03c1\u03b5\u03c2. \u03a3\u03b5 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c7\u03c1\u03bf\u03bd\u03b9\u03ba\u03ae\u03c2 \u03c3\u03c4\u03b9\u03b3\u03bc\u03ae\u03c2 \u03bc\u03b5 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ae \u03c0\u03c1\u03bf\u03ad\u03bb\u03b5\u03c5\u03c3\u03b7, \u03b1\u03c1\u03b9\u03b8\u03bc\u03cc \u03b5\u03be\u03b5\u03c4\u03b1\u03c3\u03b8\u03ad\u03bd\u03c4\u03c9\u03bd, \u03c6\u03cd\u03bb\u03bf, \u03b7\u03bb\u03b9\u03ba\u03af\u03b1, \u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03b9\u03c9\u03b4\u03af\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03ba\u03c1\u03b9\u03c4\u03ae\u03c1\u03b9\u03b1 \u03bf\u03c1\u03b9\u03c3\u03bc\u03bf\u03cd \u03a5\u03a5\u0398 \u03b4\u03b9\u03b1\u03c0\u03b9\u03c3\u03c4\u03ce\u03b8\u03b7\u03ba\u03b1\u03bd \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03ac \u03b1\u03bd\u03b5\u03cd\u03c1\u03b5\u03c3\u03b7\u03c2 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03c9\u03bd \u03c4\u03b9\u03bc\u03ce\u03bd TSH \u03c0\u03bf\u03c5 \u03ba\u03c5\u03bc\u03b1\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03bd \u03b1\u03c0\u03cc 1,4-7,8% \u03c3\u03b5 \u03bc\u03b9\u03ba\u03c4\u03cc \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03cc, \u03c4\u03b1 \u03bf\u03c0\u03bf\u03af\u03b1 \u03b1\u03c5\u03be\u03ac\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03ac\u03bd\u03c9 \u03c4\u03c9\u03bd 60 \u03b5\u03c4\u03ce\u03bd. \u03a3\u03c4\u03b9\u03c2 \u03b3\u03c5\u03bd\u03b1\u03af\u03ba\u03b5\u03c2 \u03ba\u03c5\u03bc\u03b1\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc 7,8-17,5% \u03ba\u03b1\u03b9 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03ac\u03bd\u03b4\u03c1\u03b5\u03c2 2,2-15,4% (\u03a0\u03af\u03bd\u03b1\u03ba\u03b1\u03c2 3<\/b>). \u03a3\u03c4\u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 Wichamm \u03c3\u03b5 \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03cc 2779 \u0392\u03c1\u03b5\u03c4\u03b1\u03bd\u03ce\u03bd \u03c4\u03b1 \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03ac \u03b1\u03bd\u03b5\u03cd\u03c1\u03b5\u03c3\u03b7\u03c2 \u03c4\u03b9\u03bc\u03ae\u03c2 TSH \u03ac\u03bd\u03c9 \u03c4\u03c9\u03bd 6,0 mU\/L \u03c3\u03c4\u03bf\u03c5\u03c2 \u03bc\u03b5\u03bd \u03ac\u03bd\u03b4\u03c1\u03b5\u03c2 \u03c0\u03b1\u03c1\u03ad\u03bc\u03b5\u03b9\u03bd\u03b1\u03bd \u03c3\u03c7\u03b5\u03b4\u03cc\u03bd \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03ac \u03bc\u03b5 \u03c4\u03b7\u03bd \u03c0\u03c1\u03cc\u03bf\u03b4\u03bf \u03c4\u03b7\u03c2 \u03b7\u03bb\u03b9\u03ba\u03af\u03b1\u03c2, \u03c3\u03c4\u03b9\u03c2 \u03b4\u03b5 \u03b3\u03c5\u03bd\u03b1\u03af\u03ba\u03b5\u03c2 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03ae\u03b8\u03b7\u03ba\u03b5 \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03ae \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03ce\u03bd \u03c0\u03bf\u03c5 \u03ad\u03c6\u03c4\u03b1\u03c3\u03b5 \u03c9\u03c2 \u03c4\u03bf 18% \u03c3\u03b5 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03b7\u03bb\u03b9\u03ba\u03af\u03b1\u03c2 \u03ac\u03bd\u03c9 \u03c4\u03c9\u03bd 74 \u03b5\u03c4\u03ce\u03bd (22) (\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 5<\/b>). \u03a0\u03b1\u03c1\u03cc\u03bc\u03bf\u03b9\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7\u03c2 \u03c7\u03c1\u03bf\u03bd\u03b9\u03ba\u03ae\u03c2 \u03c3\u03c4\u03b9\u03b3\u03bc\u03ae\u03c2 Colorado \u03cc\u03c0\u03bf\u03c5 \u03c4\u03bf \u03bc\u03ad\u03c3\u03bf \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03b1\u03bd\u03b5\u03cd\u03c1\u03b5\u03c3\u03b7\u03c2 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7\u03c2 TSH \u03ae\u03c4\u03b1\u03bd 9,5% \u03c3\u03c4\u03bf \u03c3\u03cd\u03bd\u03bf\u03bb\u03bf \u03c4\u03bf\u03c5 \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03bf\u03cd \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b1 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03ac\u03bd\u03c9 \u03c4\u03c9\u03bd 74 \u03b5\u03c4\u03ce\u03bd \u03ae\u03c4\u03b1\u03bd 16 \u03ba\u03b1\u03b9 21% \u03c3\u03b5 \u03ac\u03bd\u03b4\u03c1\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03b3\u03c5\u03bd\u03b1\u03af\u03ba\u03b5\u03c2 \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03bf\u03b9\u03c7\u03b1 (17).<\/p>\n \u03a0\u03af\u03bd\u03b1\u03ba\u03b1\u03c2 3. <\/b>\u03a0\u03bf\u03c3\u03bf\u03c3\u03c4\u03ac \u03b1\u03bd\u03af\u03c7\u03bd\u03b5\u03c5\u03c3\u03b7\u03c2 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7\u03c2 \u03c4\u03b9\u03bc\u03ae\u03c2 TSH \u03c3\u03b5 \u03ac\u03c4\u03bf\u03bc\u03b1 >60 \u03b5\u03c4\u03ce\u03bd (\u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c7\u03c1\u03bf\u03bd\u03b9\u03ba\u03ae\u03c2 \u03c3\u03c4\u03b9\u03b3\u03bc\u03ae\u03c2).<\/p>\n\n <\/p>\n \n\n\n| \u00a0<\/span><\/td>\n | \u0392\u03b9\u03b2\u03bb\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1<\/b><\/span><\/td>\n | \n \u0388\u03c4\u03bf\u03c2<\/b><\/span><\/p>\n<\/td>\n | \n \u03a0\u03c1\u03bf\u03ad\u03bb\u03b5\u03c5\u03c3\u03b7<\/b><\/span><\/p>\n<\/td>\n | \n \u039d \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd<\/b><\/span><\/p>\n<\/td>\n | \n \u0397\u03bb\u03b9\u03ba\u03af\u03b1<\/b><\/span><\/p>\n<\/td>\n | \n % \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 <\/b>TSH<\/b><\/span><\/p>\n<\/td>\n | \u00a0<\/span><\/td>\n<\/tr>\n\n| \n 1<\/b><\/p>\n<\/td>\n | Falkenberg M et al (111)<\/td>\n | \n 1983<\/p>\n<\/td>\n | \n Ryral Swedin<\/p>\n<\/td>\n | \n 1442<\/p>\n<\/td>\n | \n >60<\/p>\n<\/td>\n | \n 1,4<\/p>\n<\/td>\n | \u2642<\/b>+<\/b>\u2640<\/b>: <\/b>1,4-7,8 %<\/td>\n<\/tr>\n\n| \n 2<\/b><\/p>\n<\/td>\n | Sawin C et al (112)<\/td>\n | \n 1985<\/p>\n<\/td>\n | \n Framinghan<\/p>\n<\/td>\n | \n 2139<\/p>\n<\/td>\n | \n >60<\/p>\n<\/td>\n | \n 7,8<\/p>\n<\/td>\n<\/tr>\n | \n| \n 3<\/b><\/p>\n<\/td>\n | Bagchi N et al (113)<\/td>\n | \n 1990<\/p>\n<\/td>\n | \n Michigan<\/p>\n<\/td>\n | \n 968<\/p>\n<\/td>\n | \n \u226555<\/p>\n<\/td>\n | \n 6,7<\/p>\n<\/td>\n<\/tr>\n | \n| \n 4<\/b><\/p>\n<\/td>\n | Mariotti S et al (114)<\/td>\n | \n 1993<\/p>\n<\/td>\n | \n Italy<\/p>\n<\/td>\n | \n 41<\/p>\n<\/td>\n | \n >100<\/p>\n<\/td>\n | \n 7,1<\/p>\n<\/td>\n<\/tr>\n | \n| \n 5<\/b><\/p>\n<\/td>\n | Manciet G et al (115)<\/td>\n | \n 1995<\/p>\n<\/td>\n | \n France<\/p>\n<\/td>\n | \n 425<\/p>\n<\/td>\n | \n \u226565<\/p>\n<\/td>\n | \n 4,2<\/p>\n<\/td>\n<\/tr>\n | \n| \n 6<\/b><\/p>\n<\/td>\n | Luboshitzky R et al (116)<\/td>\n | \n 1996<\/p>\n<\/td>\n | \n Israel<\/p>\n<\/td>\n | \n 751<\/p>\n<\/td>\n | \n \u226565<\/p>\n<\/td>\n | \n 4,9<\/p>\n<\/td>\n<\/tr>\n | \n| <\/td>\n | <\/td>\n | <\/td>\n | <\/td>\n | <\/td>\n | <\/td>\n | \n \u2640<\/b><\/b><\/p>\n<\/td>\n | \n \u2642<\/b><\/p>\n<\/td>\n | <\/td>\n<\/tr>\n | \n| \n 7<\/b><\/p>\n<\/td>\n | Sawin C et al (117)<\/td>\n | \n 1979<\/p>\n<\/td>\n | \n Massachusetts<\/p>\n<\/td>\n | \n 344<\/p>\n<\/td>\n | \n \u226565<\/p>\n<\/td>\n | \n 16,9<\/p>\n<\/td>\n | \n 8,2<\/p>\n<\/td>\n | \u2640<\/b>: <\/b>7,8 \u2013 17,5 %\u2642: <\/b>2,2 \u2013 15,4 %<\/td>\n<\/tr>\n\n| \n 8<\/b><\/b><\/p>\n<\/td>\n | Livingston E et al (118)<\/td>\n | \u00a01987<\/td>\n | \u00a0California<\/td>\n | <\/td>\n | \u00a0>60<\/td>\n | <\/td>\n | \u00a05,1<\/td>\n<\/tr>\n | \n| \n 9<\/b><\/b><\/p>\n<\/td>\n | Rosenthal M et al (119)<\/td>\n | \u00a01987<\/td>\n | \u00a0New Mexico<\/td>\n | \u00a0258<\/td>\n | \u00a0>60<\/td>\n | \u00a016,2<\/td>\n | \u00a09,5<\/td>\n<\/tr>\n | \n| \n 10<\/b><\/b><\/p>\n<\/td>\n | Brochmann H et al (120)<\/td>\n | \u00a01988<\/td>\n | \u00a0Norway<\/td>\n | \u00a0194<\/td>\n | \u00a0>70<\/td>\n | \u00a07,0<\/td>\n | \u00a02,8<\/td>\n<\/tr>\n | \n| 11<\/b><\/td>\n | Drinka P et al (121)<\/td>\n | \u00a01990<\/td>\n | \u00a0Wisconsin<\/td>\n | \u00a0571<\/td>\n | \u00a0\u226560<\/td>\n | \u00a014,6<\/td>\n | \u00a09,7<\/td>\n<\/tr>\n | \n| 12<\/b><\/td>\n | Parke J et al<\/td>\n | \u00a01990<\/td>\n | Great Britain<\/td>\n | \u00a0194<\/td>\n | \u00a0>70<\/td>\n | \u00a09,5<\/td>\n | \u00a02,2<\/td>\n<\/tr>\n | \n| 13<\/b><\/td>\n | Bemben D et al (122)<\/td>\n | \u00a01994<\/td>\n | \u00a0Oklahoma<\/td>\n | \u00a0283<\/td>\n | \u226560<\/td>\n | \u00a014,6<\/td>\n | \u00a015,4<\/td>\n<\/tr>\n | \n| 14<\/b><\/td>\n | Jayme J et al (123)<\/td>\n | \u00a01994<\/td>\n | \u00a0Maryland<\/td>\n | \u00a03410<\/td>\n | \u00a0>60<\/td>\n | \u00a017,5<\/td>\n | \u00a013,7<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n \u00a0<\/b><\/p>\n
\n <\/p>\n ![\"10.17image5\"](\"https:\/\/e-endocrinology.gr\/wp-content\/uploads\/2015\/02\/10.17image5.jpg\") <\/p>\n
\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 5.<\/b> \u03a0\u03bf\u03c3\u03bf\u03c3\u03c4\u03ac \u03b1\u03bd\u03b5\u03cd\u03c1\u03b5\u03c3\u03b7\u03c2 \u03c4\u03b9\u03bc\u03ae\u03c2 TSH >6 mU\/L \u03c3\u03b5 \u03b3\u03c5\u03bd\u03b1\u03af\u03ba\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03ac\u03bd\u03c4\u03c1\u03b5\u03c2 \u03c3\u03cd\u03bc\u03c6\u03c9\u03bd\u03b1 \u03bc\u03b5 \u03c4\u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 Wickham Vanderpump MP et al (22).<\/p>\n
\n \u03a5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 4 \u03c0\u03c1\u03bf\u03bf\u03c0\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b5\u03c0\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03a5\u03a5\u0398 \u03c3\u03b5 \u03b7\u03bb\u03b9\u03ba\u03b9\u03c9\u03bc\u03ad\u03bd\u03b1 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03c4\u03b1 \u03bf\u03c0\u03bf\u03af\u03b1 \u03b5\u03af\u03c7\u03b1\u03bd \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03c4\u03b9\u03bc\u03ad\u03c2 TSH \u03c3\u03c4\u03b7\u03bd \u03ad\u03bd\u03b1\u03c1\u03be\u03b7 \u03c4\u03b7\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7\u03c2. \u03a4\u03bf \u03c7\u03c1\u03bf\u03bd\u03b9\u03ba\u03cc \u03b4\u03b9\u03ac\u03c3\u03c4\u03b7\u03bc\u03b1 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7\u03c2 \u03ba\u03c5\u03bc\u03b1\u03b9\u03bd\u03cc\u03c4\u03b1\u03bd \u03b1\u03c0\u03cc 4-20 \u03ad\u03c4\u03b7. \u0395\u03c5\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03ac\u03c4\u03bf\u03bc\u03b1 \u03bc\u03b5 \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc \u03c4\u03af\u03c4\u03bb\u03bf \u03b1\u03bd\u03c4\u03b9\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd (\u0391\u03a4\u0391) \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b1\u03bd \u03b5\u03c4\u03ae\u03c3\u03b9\u03bf \u03c1\u03c5\u03b8\u03bc\u03cc \u03bc\u03b5\u03c4\u03ac\u03c0\u03c4\u03c9\u03c3\u03b7\u03c2 \u03c3\u03b5 \u03c5\u03c0\u03bf\u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03ae \u03ad\u03ba\u03b4\u03b7\u03bb\u03bf \u03c5\u03c0\u03bf\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03c3\u03bc\u03cc \u03c4\u03bf\u03c5\u03bb\u03ac\u03c7\u03b9\u03c3\u03c4\u03bf\u03bd 20%, \u03b5\u03bd\u03ce \u03b5\u03ba\u03b5\u03af\u03bd\u03b1 \u03bc\u03b5 \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03ac \u0391\u03a4\u0391 \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b1\u03bd \u03bc\u03b9\u03ba\u03c1\u03cc\u03c4\u03b5\u03c1\u03bf \u03c1\u03c5\u03b8\u03bc\u03cc (\u03c0\u03af\u03bd\u03b1\u03ba\u03b1\u03c2 4<\/b>).<\/p>\n \u03a0\u03af\u03bd\u03b1\u03ba\u03b1\u03c2 4. <\/b>\u0395\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7 \u03c5\u03c0\u03bf\u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03bf\u03cd \u03c5\u03c0\u03bf\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03c3\u03bc\u03bf\u03cd \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b7\u03bb\u03b9\u03ba\u03b9\u03c9\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2 \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7 \u03ae \u03cc\u03c7\u03b9 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd (\u03c0\u03c1\u03bf\u03bf\u03c0\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2).<\/p>\n\n \n\n\n| \n \u00a0<\/b><\/span><\/p>\n<\/td>\n | \u0392\u03b9\u03b2\u03bb\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1<\/b><\/span><\/td>\n | \n \u0388\u03c4\u03bf\u03c2<\/b><\/b><\/span><\/p>\n<\/td>\n | \n \u039d\u03bf \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd<\/b><\/span><\/p>\n<\/td>\n | \n \u0394\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1<\/b><\/span><\/p>\n<\/td>\n | \n % \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 <\/b>TSH<\/b><\/b><\/span><\/p>\n<\/td>\n<\/tr>\n\n| \n +<\/b>Abs<\/b><\/b><\/span><\/p>\n<\/td>\n | \n -Abs<\/b><\/b><\/span><\/p>\n<\/td>\n<\/tr>\n\n| \n 1<\/p>\n<\/td>\n | Rosenthal M et al<\/td>\n | \n 1987<\/p>\n<\/td>\n | \n 1758<\/p>\n<\/td>\n | \n 6 \u03c7\u03c1.<\/p>\n<\/td>\n | \n 23<\/p>\n<\/td>\n | \n 1,7<\/p>\n<\/td>\n<\/tr>\n | \n| \n 2<\/p>\n<\/td>\n | Hawkins B et al (124)<\/td>\n | \n 1980<\/p>\n<\/td>\n | \n 24<\/p>\n<\/td>\n | \n 4 \u03c7\u03c1.<\/p>\n<\/td>\n | \n 8,3<\/p>\n<\/td>\n | \n 0<\/p>\n<\/td>\n<\/tr>\n | \n| \n 3<\/p>\n<\/td>\n | Geul K et al (125)<\/td>\n | \n 1993<\/p>\n<\/td>\n | \n 427 \u2640<\/p>\n<\/td>\n | \n 10 \u03c7\u03c1.<\/p>\n<\/td>\n | \n 24<\/p>\n<\/td>\n | \n 3<\/p>\n<\/td>\n<\/tr>\n | \n| \n 4<\/p>\n<\/td>\n | Vanderpump M et al (22)<\/td>\n | \n 1995<\/p>\n<\/td>\n | \n 942 \u2640<\/p>\n<\/td>\n | \n 20 \u03c7\u03c1.<\/p>\n<\/td>\n | \n 2,1<\/p>\n<\/td>\n | \n 0,3<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n \u039c\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c7\u03c1\u03bf\u03bd\u03b9\u03ba\u03ae\u03c2 \u03c3\u03c4\u03b9\u03b3\u03bc\u03ae\u03c2 \u03b4\u03b5\u03af\u03c7\u03bd\u03bf\u03c5\u03bd \u03cc\u03c4\u03b9 \u03c4\u03bf \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03b1\u03bd\u03af\u03c7\u03bd\u03b5\u03c5\u03c3\u03b7\u03c2 \u03b8\u03b5\u03c4\u03b9\u03ba\u03ce\u03bd \u0391\u03a4\u0391 \u03ba\u03c5\u03bc\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc 15-20% \u03c3\u03c4\u03b1 \u03b7\u03bb\u03b9\u03ba\u03b9\u03c9\u03bc\u03ad\u03bd\u03b1 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03ba\u03b1\u03b9 40-67% \u03c3\u03b5 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03bc\u03b5 \u03a5\u03a5\u0398 (22, 23). \u0395\u03bd\u03b4\u03b9\u03b1\u03c6\u03ad\u03c1\u03bf\u03bd \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03b9\u03ac\u03b6\u03b5\u03b9 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03b7 \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03b9\u03b1\u03af\u03b1 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u0391\u03a4\u0391 \u03c0\u03bf\u03c5 \u03b2\u03b1\u03af\u03bd\u03b5\u03b9 \u03b1\u03c5\u03be\u03b1\u03bd\u03cc\u03bc\u03b5\u03bd\u03b7 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b7\u03bb\u03b9\u03ba\u03af\u03b1, \u03bc\u03b5 \u03c4\u03b7\u03bd \u03ba\u03bb\u03b9\u03bc\u03b1\u03ba\u03c9\u03c4\u03ae \u03c9\u03c3\u03c4\u03cc\u03c3\u03bf \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 TSH \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03b5\u03b9 \u03b5\u03bd\u03c4\u03cc\u03c2 \u03c4\u03c9\u03bd \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ce\u03bd \u03bf\u03c1\u03af\u03c9\u03bd (\u03a0\u03af\u03bd\u03b1\u03ba\u03b1\u03c2 5<\/b>).<\/p>\n \u03a0\u03af\u03bd\u03b1\u03ba\u03b1\u03c2 5.<\/b> \u03a3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b1\u03bd\u03af\u03c7\u03bd\u03b5\u03c5\u03c3\u03b7\u03c2 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03ba\u03bb\u03b9\u03bc\u03ac\u03ba\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c4\u03b9\u03bc\u03ae\u03c2 \u03c4\u03b7\u03c2 TSH [Vanderpump MP et al, Samuels MH et al (22, 23)].<\/p>\n<\/div>\n \n \n\n\n| \n TSH<\/b> (<\/b>mIU<\/b>\/<\/b>L<\/b>)<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n\n| \n \u0397\u03bb\u03b9\u03ba\u03af\u03b1 (\u03ad\u03c4\u03b7)
\nAbs<\/b> <\/b>
\n<\/b><\/p>\n<\/td>\n | \n \u00a0 1
\n(-)\u00a0 (+) <\/b>
\n<\/b><\/p>\n<\/td>\n | \n 2
\n(-)\u00a0 (+) <\/b>
\n<\/b><\/p>\n<\/td>\n | \n 3
\n(-)\u00a0 (+) <\/b>
\n<\/b><\/p>\n<\/td>\n | \n 4
\n(-)\u00a0 (+) <\/b>
\n<\/b><\/p>\n<\/td>\n | \n 5
\n(-)\u00a0 (+) <\/b>
\n<\/b><\/p>\n<\/td>\n<\/tr>\n\n| \n 20<\/p>\n<\/td>\n | \n 1\u00a0\u00a0 6<\/p>\n<\/td>\n | \n 1\u00a0 6<\/p>\n<\/td>\n | \n 3\u00a0\u00a0 13<\/p>\n<\/td>\n | \n 4\u00a0\u00a0 21<\/p>\n<\/td>\n | \n 7\u00a0\u00a0 29<\/p>\n<\/td>\n<\/tr>\n | \n| \n 30<\/p>\n<\/td>\n | \n 1\u00a0\u00a0 8<\/p>\n<\/td>\n | \n 2\u00a0 8<\/p>\n<\/td>\n | \n 3\u00a0\u00a0 17<\/p>\n<\/td>\n | \n 6\u00a0\u00a0 26<\/p>\n<\/td>\n | \n 8\u00a0\u00a0 35<\/p>\n<\/td>\n<\/tr>\n | \n| \n 40<\/p>\n<\/td>\n | \n 2\u00a0\u00a0 10<\/p>\n<\/td>\n | \n 2\u00a0\u00a0 11<\/p>\n<\/td>\n | \n 4\u00a0\u00a0 21<\/p>\n<\/td>\n | \n 7\u00a0\u00a0 32<\/p>\n<\/td>\n | \n 11\u00a0\u00a0 42<\/p>\n<\/td>\n<\/tr>\n | \n| \n 50<\/p>\n<\/td>\n | \n 2\u00a0\u00a0 13<\/p>\n<\/td>\n | \n 3\u00a0\u00a0 13<\/p>\n<\/td>\n | \n 5\u00a0\u00a0 25<\/p>\n<\/td>\n | \n 9\u00a0\u00a0 38<\/p>\n<\/td>\n | \n 14\u00a0\u00a0 48<\/p>\n<\/td>\n<\/tr>\n | \n| \n 60<\/p>\n<\/td>\n | \n 3\u00a0\u00a0 17<\/p>\n<\/td>\n | \n 3\u00a0\u00a0 17<\/p>\n<\/td>\n | \n 7\u00a0\u00a0 31<\/p>\n<\/td>\n | \n 12\u00a0 44<\/p>\n<\/td>\n | \n 17\u00a0\u00a0 55<\/p>\n<\/td>\n<\/tr>\n | \n| \n 70<\/p>\n<\/td>\n | \n 4\u00a0\u00a0 21<\/p>\n<\/td>\n | \n 4\u00a0\u00a0 21<\/p>\n<\/td>\n | \n 9\u00a0\u00a0 37<\/p>\n<\/td>\n | \n 15\u00a0 51<\/p>\n<\/td>\n | \n 21\u00a0\u00a0 62<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n 3.2. \u0397 \u03b1\u03be\u03b9\u03bf\u03c0\u03b9\u03c3\u03c4\u03af\u03b1 \u03ba\u03b1\u03b9 \u03b7 \u03b4\u03b9\u03b1\u03ba\u03cd\u03bc\u03b1\u03bd\u03c3\u03b7 \u03c4\u03b7\u03c2 <\/b>TSH<\/b><\/h5>\n\u038c\u03c0\u03c9\u03c2 \u03c3\u03c5\u03bc\u03b2\u03b1\u03af\u03bd\u03b5\u03b9 \u03c3\u03b5 \u03ba\u03ac\u03b8\u03b5 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bb\u03b7\u03c4\u03ae, \u03ad\u03c4\u03c3\u03b9 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b9\u03c2 \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03c4\u03c1\u03bf\u03c5\u03c2 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2 \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03bc\u03b9\u03b1 \u03b4\u03b9\u03b1\u03ba\u03cd\u03bc\u03b1\u03bd\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c4\u03b9\u03bc\u03ce\u03bd \u03c0\u03bf\u03c5 \u03c0\u03bf\u03b9\u03ba\u03af\u03bb\u03bb\u03b5\u03b9 \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03b7 \u03bc\u03b5\u03b8\u03bf\u03b4\u03bf\u03bb\u03bf\u03b3\u03af\u03b1, \u03c4\u03bf \u03c0\u03c1\u03c9\u03c4\u03cc\u03ba\u03bf\u03bb\u03bb\u03bf, \u03c4\u03b9\u03c2 \u03c4\u03b5\u03c7\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b4\u03c5\u03bd\u03b1\u03c4\u03cc\u03c4\u03b7\u03c4\u03b5\u03c2 \u03ba\u03bb\u03c0. \u0388\u03c4\u03c3\u03b9 \u03b7 \u03bb\u03b5\u03b3\u03cc\u03bc\u03b5\u03bd\u03b7 \u03b4\u03b9\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae \u03b1\u03bd\u03b1\u03bb\u03c5\u03c4\u03b9\u03ba\u03ae \u03b4\u03b9\u03b1\u03ba\u03cd\u03bc\u03b1\u03bd\u03c3\u03b7 (interassay CV) \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd TSH \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b1 \u03b1\u03bd\u03ad\u03c1\u03c7\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf 10%, \u03b5\u03bd\u03ce \u03b7 \u03b5\u03bd\u03b4\u03bf-\u03b1\u03c4\u03bf\u03bc\u03b9\u03ba\u03ae \u03ba\u03b1\u03b9 \u03b4\u03b9\u03b1-\u03b1\u03c4\u03bf\u03bc\u03b9\u03ba\u03ae \u03b4\u03b9\u03b1\u03ba\u03cd\u03bc\u03b1\u03bd\u03c3\u03b7 \u03c3\u03c4\u03bf 30 \u03ba\u03b1\u03b970% \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03bf\u03b9\u03c7\u03b1 (\u03c3\u03cd\u03bc\u03c6\u03c9\u03bd\u03b1 \u03bc\u03b5 \u03c4\u03bf \u039dational \u0391cademy of \u00a0Clinical Biochemistry).<\/p>\n \u039f \u03bb\u03cc\u03b3\u03bf\u03c2 \u03b5\u03bd\u03b4\u03bf- \u03c0\u03c1\u03bf\u03c2 \u03b4\u03b9\u03b1-\u03b1\u03c4\u03bf\u03bc\u03b9\u03ba\u03ae \u03b4\u03b9\u03b1\u03ba\u03cd\u03bc\u03b1\u03bd\u03c3\u03b7 (\u03b8\u03b1 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03c3\u03b5 \u03bd\u03b1 \u03bf\u03bd\u03bf\u03bc\u03b1\u03c3\u03b8\u03b5\u03af \u03ba\u03b1\u03b9 \u03b4\u03b5\u03af\u03ba\u03c4\u03b7\u03c2 \u03b1\u03c4\u03bf\u03bc\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2) \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03b5\u03af \u03c0\u03c1\u03bf\u03ba\u03b5\u03b9\u03bc\u03ad\u03bd\u03bf\u03c5 \u03bd\u03b1 \u03ba\u03b1\u03b8\u03bf\u03c1\u03af\u03c3\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03b9\u03b1\u03ba\u03ce\u03bd \u03c4\u03b9\u03bc\u03ce\u03bd \u03b1\u03bd\u03b1\u03c6\u03bf\u03c1\u03ac\u03c2 \u03c3\u03c4\u03b7\u03bd \u03b1\u03bd\u03af\u03c7\u03bd\u03b5\u03c5\u03c3\u03b7 \u03bc\u03b9\u03b1\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5 \u03c3\u03b5 \u03ad\u03bd\u03b1 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03bf \u03ac\u03c4\u03bf\u03bc\u03bf. \u038c\u03c4\u03b1\u03bd \u03bf \u03bb\u03cc\u03b3\u03bf\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03ba\u03c1\u03cc\u03c4\u03b5\u03c1\u03bf\u03c2 \u03b1\u03c0\u03cc 0,6 \u03c4\u03b1 \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03b9\u03b1\u03ba\u03ac \u03cc\u03c1\u03b9\u03b1 \u03b1\u03bd\u03b1\u03c6\u03bf\u03c1\u03ac\u03c2 \u03b5\u03af\u03bc\u03b1\u03b9 \u03bc\u03b7 \u03b5\u03c5\u03b1\u03af\u03c3\u03b8\u03b7\u03c4\u03b7 \u03bc\u03ad\u03c4\u03c1\u03b7\u03c3\u03b7 \u03c3\u03c4\u03b7\u03bd \u03c0\u03bb\u03b5\u03b9\u03bf\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03c9\u03bd \u03b1\u03c4\u03cc\u03bc\u03c9\u03bd.<\/p>\n \u039f \u03b4\u03b5\u03af\u03ba\u03c4\u03b7\u03c2 \u03b1\u03c5\u03c4\u03cc\u03c2 \u03c3\u03b5 3 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03ba\u03c5\u03bc\u03b1\u03b9\u03bd\u03cc\u03c4\u03b1\u03bd \u03b1\u03c0\u03cc 0,36-0,5 (12,24,25). \u03a3\u03b5 \u03b5\u03bd\u03b4\u03b9\u03b1\u03c6\u03ad\u03c1\u03bf\u03c5\u03c3\u03b1 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03c4\u03c9\u03bd Andersen \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bd \u03bf\u03b9 \u03bf\u03c0\u03bf\u03af\u03bf\u03b9 \u03bc\u03ad\u03c4\u03c1\u03b7\u03c3\u03b1\u03bd \u03c4\u03b9\u03c2 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ad\u03c2 \u03c4\u03c9\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03bf\u03c1\u03bc\u03bf\u03bd\u03ce\u03bd \u03c3\u03b5 16 \u03c5\u03b3\u03b9\u03b5\u03af\u03c2 \u03ac\u03bd\u03b4\u03c1\u03b5\u03c2 \u03ba\u03ac\u03b8\u03b5 \u03bc\u03ae\u03bd\u03b1 \u03bc\u03b5\u03c4\u03c1\u03ae\u03c3\u03b5\u03b9\u03c2, \u03b3\u03b9\u03b1 12 \u03bc\u03ae\u03bd\u03b5\u03c2, \u03b2\u03c1\u03ae\u03ba\u03b1\u03bd \u03cc\u03c4\u03b9 \u03b7 \u03c4\u03b9\u03bc\u03ae \u03c4\u03b7\u03c2 TSH \u03ba\u03ac\u03b8\u03b5 \u03b1\u03c4\u03cc\u03bc\u03bf\u03c5 \u03ba\u03c5\u03bc\u03b1\u03b9\u03bd\u03cc\u03c4\u03b1\u03bd \u03c3\u03c4\u03bf 50% \u03c4\u03b7\u03c2 \u03b4\u03b9\u03b1\u03ba\u03cd\u03bc\u03b1\u03bd\u03c3\u03b7\u03c2 \u03c3\u03c4\u03bf \u03c3\u03cd\u03bd\u03bf\u03bb\u03bf \u03c4\u03c9\u03bd \u03b1\u03c4\u03cc\u03bc\u03c9\u03bd (24). \u0388\u03c4\u03c3\u03b9 \u03bc\u03b5 \u03bc\u03ad\u03c3\u03b7 \u03c4\u03b9\u03bc\u03ae TSH \u03c0.\u03c7 1,4 mU\/L \u03bf\u03b9 \u03b5\u03c0\u03b1\u03bd\u03b1\u03bb\u03b1\u03bc\u03b2\u03b1\u03bd\u03cc\u03bc\u03b5\u03bd\u03b5\u03c2 \u03c3\u03c4\u03bf \u03af\u03b4\u03b9\u03bf \u03ac\u03c4\u03bf\u03bc\u03bf \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c0\u03bf\u03b9\u03ba\u03af\u03bb\u03bb\u03bf\u03c5\u03bd \u03b1\u03c0\u03cc 0,7-2,1 mU\/L, \u03b5\u03bd\u03ce \u03b1\u03bd \u03ae\u03c4\u03b1\u03bd 3,6 mU\/L \u03c4\u03b1 \u03cc\u03c1\u03b9\u03b1 \u03b4\u03b9\u03b1\u03ba\u03cd\u03bc\u03b1\u03bd\u03c3\u03b7\u03c2 \u03b8\u03b1 \u03ae\u03c4\u03b1\u03bd 1,8-5,4 mU\/L. \u0393\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b5\u03bc\u03c6\u03b1\u03bd\u03ad\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf \u03b4\u03b5\u03cd\u03c4\u03b5\u03c1\u03bf \u03c0\u03b1\u03c1\u03ac\u03b4\u03b5\u03b9\u03b3\u03bc\u03b1 \u03cc\u03c4\u03b9 \u03bf\u03b9 \u03c4\u03b9\u03bc\u03ad\u03c2 \u03b1\u03c5\u03c4\u03ad\u03c2 \u03b8\u03b1 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03c3\u03b1\u03bd \u03bd\u03b1 \u03c4\u03b1\u03be\u03b9\u03bd\u03bf\u03bc\u03ae\u03c3\u03bf\u03c5\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bb\u03b1\u03bd\u03b8\u03b1\u03c3\u03bc\u03ad\u03bd\u03b1 \u03c9\u03c2 \u03c0\u03ac\u03c3\u03c7\u03bf\u03bd\u03c4\u03b5\u03c2 \u03c0\u03b1\u03c1\u03cc\u03c4\u03b9 \u03bf\u03b9 \u03bc\u03ad\u03c3\u03b5\u03c2 \u03b4\u03b9\u03b1\u03c7\u03c1\u03bf\u03bd\u03b9\u03ba\u03ad\u03c2 \u03c3\u03c5\u03b3\u03ba\u03b5\u03bd\u03c4\u03c1\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c3\u03c4\u03bf \u03af\u03b4\u03b9\u03bf \u03ac\u03c4\u03bf\u03bc\u03bf \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03bd\u03c4\u03b5\u03bb\u03ce\u03c2 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2. \u0388\u03bd\u03b1\u03c2 \u03b5\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c0\u03bf\u03c5 \u03c3\u03c5\u03bc\u03b2\u03ac\u03bb\u03bb\u03b5\u03b9 \u03c3\u03b5 \u03b5\u03bd\u03b4\u03b5\u03c7\u03cc\u03bc\u03b5\u03bd\u03b7 \u03bb\u03b1\u03bd\u03b8\u03b1\u03c3\u03bc\u03ad\u03bd\u03b7 \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03b7 \u03b7\u03bc\u03b5\u03c1\u03ae\u03c3\u03b9\u03b1 \u03b4\u03b9\u03b1\u03ba\u03cd\u03bc\u03b1\u03bd\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c4\u03b9\u03bc\u03ce\u03bd \u03c4\u03b7\u03c2 TSH \u03c0\u03bf\u03c5 \u03b1\u03bd\u03ad\u03c1\u03c7\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf 26,5% \u03bc\u03b5 \u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b1 \u03c4\u03b1 \u03c0\u03c1\u03c9\u03b9\u03bd\u03ac \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1, \u03ba\u03b1\u03b8\u03ce\u03c2 \u03ba\u03b1\u03b9 \u03b7 \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bb\u03ae\u03c8\u03b7\u03c2 \u03c6\u03b1\u03b3\u03b7\u03c4\u03bf\u03cd \u03c0\u03bf\u03c5 \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03ac \u03c4\u03b7\u03c2 (24). \u03a3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b1\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03cc\u03c3\u03bf \u03c0\u03b9\u03bf \u03c3\u03c4\u03b5\u03bd\u03cc \u03c4\u03bf \u03c0\u03b1\u03c1\u03ac\u03b8\u03c5\u03c1\u03bf \u03c4\u03c9\u03bd \u03bf\u03c1\u03af\u03c9\u03bd \u03b1\u03bd\u03b1\u03c6\u03bf\u03c1\u03ac\u03c2 \u03c4\u03cc\u03c3\u03bf \u03c0\u03b9\u03bf \u03bc\u03b5\u03b3\u03ac\u03bb\u03b7 \u03b7 \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c0\u03b1\u03c1\u03b1\u03c0\u03bb\u03b1\u03bd\u03b7\u03c4\u03b9\u03ba\u03bf\u03cd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03bf\u03c2.<\/p>\n 3.3. \u0397 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03c4\u03b7\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2 \u03c4\u03bf\u03c5 \u03c5\u03c0\u03bf\u03b8\u03b1\u03bb\u03b1\u03bc\u03bf-\u03c5\u03c0\u03bf\u03c6\u03c5\u03c3\u03b9\u03b1\u03ba\u03bf\u03cd- \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03bf\u03cd \u03ac\u03be\u03bf\u03bd\u03b1-\u03c0\u03b5\u03c1\u03b9\u03c6\u03b5\u03c1\u03b9\u03ba\u03ce\u03bd \u03b9\u03c3\u03c4\u03ce\u03bd \u03c3\u03c4\u03cc\u03c7\u03c9\u03bd \u03ba\u03b1\u03b9 \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b7\u03bb\u03b9\u03ba\u03af\u03b1\u03c2 \u03c3\u03b5 \u03b1\u03c5\u03c4\u03cc\u03bd<\/b><\/h5>\n\u0388\u03c7\u03b5\u03b9 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b7\u03b8\u03b5\u03af \u03cc\u03c4\u03b9 \u03b4\u03b9\u03ac\u03c6\u03bf\u03c1\u03bf\u03b9 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2 \u03ba\u03b1\u03b8\u03ce\u03c2 \u03ba\u03b1\u03b9 \u03b7 \u03c0\u03c1\u03cc\u03bf\u03b4\u03bf\u03c2 \u03b7\u03bb\u03b9\u03ba\u03af\u03b1\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b1\u03c3\u03ba\u03ae\u03c3\u03bf\u03c5\u03bd \u03b4\u03c1\u03ac\u03c3\u03b7 \u03c3\u03c4\u03b1 \u03b5\u03c0\u03b9\u03bc\u03ad\u03c1\u03bf\u03c5\u03c2 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03bf\u03c5 \u03ac\u03be\u03bf\u03bd\u03b1, \u03cc\u03c0\u03c9\u03c2 \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b9\u03c2 \u03b5\u03b9\u03ba\u03cc\u03bd\u03b5\u03c2 6<\/b> \u03ba\u03b1\u03b9 7<\/b> \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03bf\u03b9\u03c7\u03b1, \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03b5\u03ba\u03b4\u03b7\u03bb\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c9\u03c2 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ae \u03ae \u03c9\u03c2 \u03b9\u03c3\u03c4\u03b9\u03ba\u03cc\u03c2 \u03c5\u03c0\u03bf\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03c3\u03bc\u03cc\u03c2 (26-29).<\/p>\n
\n ![\"10.17image6\"](\"https:\/\/e-endocrinology.gr\/wp-content\/uploads\/2015\/02\/10.17image6.jpg\") <\/p>\n
\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 6.<\/strong> \u039c\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ad\u03c2 \u03c4\u03bf\u03c5 \u03a5-\u03a5-\u0398 \u03ac\u03be\u03bf\u03bd\u03b1 \u03ba\u03b1\u03c4\u03ac \u03c4\u03bf \u03b3\u03ae\u03c1\u03b1\u03c2.<\/p>\n
\n![\"10.17image7\"](\"https:\/\/e-endocrinology.gr\/wp-content\/uploads\/2015\/02\/10.17image7.jpg\") <\/p>\n
\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 7<\/strong>. \u039c\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ad\u03c2 \u03c4\u03c9\u03bd \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03c4\u03c1\u03c9\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae\u03c2 \u03bf\u03b9\u03ba\u03bf\u03bd\u03bf\u03bc\u03af\u03b1\u03c2 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b7\u03bb\u03b9\u03ba\u03af\u03b1.<\/p>\n
\n\u00a0<\/b>3.4. \u0395\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bc\u03b7 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae\u03c2 \u03bd\u03cc\u03c3\u03b7\u03c3\u03b7\u03c2 \u03c3\u03c4\u03b7\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae \u03bf\u03b9\u03ba\u03bf\u03bd\u03bf\u03bc\u03af\u03b1<\/b><\/h5>\n\u03a3\u03b5 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c3\u03bf\u03b2\u03b1\u03c1\u03ae\u03c2 \u03bc\u03b7 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae\u03c2 \u03bd\u03cc\u03c3\u03b7\u03c3\u03b7\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b4\u03c5\u03bd\u03b1\u03c4\u03cc\u03bd \u03bd\u03b1 \u03b5\u03bc\u03c6\u03b1\u03bd\u03b9\u03c3\u03b8\u03bf\u03cd\u03bd \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c3\u03c5\u03bd\u03ad\u03c0\u03b5\u03b9\u03b5\u03c2 \u03c3\u03c4\u03b9\u03c2 \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03c4\u03c1\u03bf\u03c5\u03c2 \u03c4\u03b7\u03c2 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03bc\u03ac\u03bb\u03b9\u03c3\u03c4\u03b1 \u03b1\u03c5\u03c4\u03ad\u03c2 \u03b2\u03b1\u03af\u03bd\u03bf\u03c5\u03bd \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03b7 \u03b2\u03b1\u03c1\u03cd\u03c4\u03b7\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03b7\u03c3\u03b7\u03c2. \u038c\u03c3\u03bf \u03b2\u03b1\u03c1\u03cd\u03c4\u03b5\u03c1\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c5\u03c4\u03ae \u03c4\u03cc\u03c3\u03bf \u03c0\u03b9\u03bf \u03c7\u03b1\u03bc\u03b7\u03bb\u03ac \u03b1\u03bd\u03b5\u03c5\u03c1\u03af\u03c3\u03ba\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03c9\u03bd \u0398\u039f \u03ba\u03b1\u03b9 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c4\u03b7\u03c2 \u03a43 (low T3 syndrome) \u03b5\u03bd\u03ce \u03c0\u03b1\u03c1\u03ac\u03bb\u03bb\u03b7\u03bb\u03b1 \u03b1\u03c5\u03be\u03ac\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03b7\u03c2 \u03b1\u03bd\u03ac\u03c3\u03c4\u03c1\u03bf\u03c6\u03b7\u03c2 \u03a43 (30) (\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 8<\/b>). \u0397 \u03c0\u03b1\u03c1\u03ac\u03bb\u03bb\u03b7\u03bb\u03b7 \u03c0\u03c4\u03ce\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03a44 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03b1\u03ba\u03cc\u03c2 \u03c0\u03c1\u03bf\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03cc\u03c2 \u03b4\u03b5\u03af\u03ba\u03c4\u03b7\u03c2 \u03ad\u03ba\u03b2\u03b1\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5 (31, 32).<\/p>\n
\n ![\"10.17image8\"](\"https:\/\/e-endocrinology.gr\/wp-content\/uploads\/2015\/02\/10.17image8.jpg\") <\/p>\n
\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 8<\/strong>. \u039c\u03b7 \u2013 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae \u03bd\u03cc\u03c3\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae \u03bf\u03b9\u03ba\u03bf\u03bd\u03bf\u03bc\u03af\u03b1.<\/p>\n
\n\u00a0<\/b>3.5. \u0395\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd \u03c3\u03c4\u03bf\u03bd \u03ac\u03be\u03bf\u03bd\u03b1<\/b><\/h5>\n\u0394\u03b9\u03ac\u03c6\u03bf\u03c1\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 \u03ae \u03bf\u03c5\u03c3\u03af\u03b5\u03c2 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03c3\u03bf\u03c5\u03bd \u03c4\u03b7 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03bf\u03c5 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03bf\u03cd \u03ac\u03be\u03bf\u03bd\u03b1 \u03c3\u03b5 \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03ac \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03bf\u03b4\u03b7\u03b3\u03ae\u03c3\u03bf\u03c5\u03bd \u03c3\u03b5 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ae \u03c4\u03c9\u03bd \u03b5\u03c0\u03b9\u03c0\u03ad\u03b4\u03c9\u03bd \u03c4\u03c9\u03bd \u0398\u039f \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 TSH \u03cc\u03c0\u03c9\u03c2 \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf\u03bd \u03c0\u03af\u03bd\u03b1\u03ba\u03b1 6<\/b> (29).<\/p>\n \u03a0\u03af\u03bd\u03b1\u03ba\u03b1\u03c2 6<\/b>.<\/b> \u0395\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd \u03c3\u03c4\u03bf\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03cc \u03ac\u03be\u03bf\u03bd\u03b1 (\u03bc\u03b5\u03c4\u03b1\u03c6\u03c1\u03b1\u03c3\u03bc\u03ad\u03bd\u03bf \u03b1\u03c0\u03cc Mooradian et al (29)].<\/p>\n\n \n\n\n| \u03a6\u03b1\u03c1\u03bc\u03b1\u03ba\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03bf\u03c5\u03c3\u03af\u03b1\u00a0 <\/b><\/span><\/td>\n | \n \u0395\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c3\u03c4\u03bf\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03cc \u03ac\u03be\u03bf\u03bd\u03b1<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n\n| \u039a\u03bf\u03c1\u03c4\u03b9\u03ba\u03bf\u03c3\u03c4\u03b5\u03c1\u03bf\u03b5\u03b9\u03b4\u03ae, \u03bd\u03c4\u03bf\u03c0\u03b1\u03bc\u03af\u03bd\u03b7, \u03bf\u03ba\u03c4\u03c1\u03b5\u03bf\u03c4\u03af\u03b4\u03b7<\/td>\n | \n \u00ad TSH<\/p>\n<\/td>\n<\/tr>\n | \n| \u0391\u03bc\u03b9\u03c9\u03b4\u03b1\u03c1\u03cc\u03bd\u03b7, \u03b9\u03c9\u03b4\u03b9\u03bf\u03cd\u03c7\u03b1<\/td>\n | \n \u00ad T4<\/p>\n<\/td>\n<\/tr>\n | \n| \u039b\u03af\u03b8\u03b9\u03bf, \u03b1\u03bc\u03b9\u03c9\u03b4\u03b1\u03c1\u03cc\u03bd\u03b7, \u03b9\u03c9\u03b4\u03b9\u03bf\u03cd\u03c7\u03b1<\/td>\n | \n \u00af T4<\/p>\n<\/td>\n<\/tr>\n | \n| \u039f\u03b9\u03c3\u03c4\u03c1\u03bf\u03b3\u03cc\u03bd\u03b1, \u03c4\u03b1\u03bc\u03bf\u03be\u03b9\u03c6\u03b1\u03af\u03bd\u03b7, \u03bc\u03b5\u03b8\u03b1\u03b4\u03cc\u03bd\u03b7, \u03b7\u03c1\u03c9\u03af\u03bd\u03b7, \u03c6\u03bb\u03bf\u03c5\u03bf\u03c1\u03bf\u03bf\u03c5\u03c1\u03b1\u03ba\u03ae\u03bb\u03b7<\/td>\n | \n \u00ad TBG<\/p>\n<\/td>\n<\/tr>\n | \n| \u0391\u03bd\u03b4\u03c1\u03bf\u03b3\u03cc\u03bd\u03b1, \u03b1\u03bd\u03b1\u03b2\u03bf\u03bb\u03b9\u03ba\u03ac, \u03ba\u03bf\u03c1\u03c4\u03b9\u03ba\u03bf\u03c3\u03c4\u03b5\u03c1\u03bf\u03b5\u03b9\u03b4\u03ae, \u03bd\u03b9\u03b1\u03c3\u03af\u03bd\u03b7<\/td>\n | \n \u00af TBG<\/p>\n<\/td>\n<\/tr>\n | \n| \u0397\u03c0\u03b1\u03c1\u03af\u03bd\u03b7, \u03c6\u03bf\u03c5\u03c1\u03bf\u03c3\u03b5\u03bc\u03af\u03b4\u03b7, \u03c3\u03b1\u03bb\u03b9\u03ba\u03c5\u03bb\u03b9\u03ba\u03ac, \u03ba.\u03b1.<\/td>\n | \n \u00af \u03b4\u03ad\u03c3\u03bc\u03b5\u03c5\u03c3\u03b7\u03c2 TBG<\/p>\n<\/td>\n<\/tr>\n | \n| \u03a6\u03b1\u03b9\u03bd\u03c5\u03bd\u03c4\u03bf\u03ca\u03bd\u03b7, \u03b2\u03b1\u03c1\u03b2\u03c5\u03c4\u03bf\u03c5\u03c1\u03b9\u03ba\u03ac, \u03c1\u03b9\u03c6\u03b1\u03bc\u03c0\u03b9\u03ba\u03af\u03bd\u03b7, \u03ba\u03b1\u03c1\u03b2\u03b1\u03bc\u03b1\u03b6\u03b5\u03c0\u03af\u03bd\u03b7<\/td>\n | \n \u00ad \u0397\u03c0\u03b1\u03c4\u03b9\u03ba\u03cc\u03c2 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03c3\u03bc\u03cc\u03c2<\/p>\n<\/td>\n<\/tr>\n | \n| \u03a0\u03c1\u03bf\u03c0\u03c5\u03b8\u03b5\u03b9\u03bf\u03c5\u03c1\u03b1\u03ba\u03ae\u03bb\u03b7, \u03b1\u03bc\u03b9\u03bf\u03b4\u03b1\u03c1\u03cc\u03bd\u03b7, \u03b2\u2019-\u03b1\u03bd\u03c4\u03b1\u03b3\u03c9\u03bd\u03b9\u03c3\u03c4\u03ad\u03c2, \u03ba\u03bf\u03c1\u03c4\u03b9\u03ba\u03bf\u03c3\u03c4\u03b5\u03c1\u03bf\u03b5\u03b9\u03b4\u03ae<\/td>\n | \n \u00af 5\u2019 \u2013TDI<\/p>\n<\/td>\n<\/tr>\n | \n| \u03a7\u03bf\u03bb\u03c5\u03c3\u03c4\u03b5\u03c1\u03b1\u03bc\u03af\u03bd\u03b7, \u03c7\u03bf\u03bb\u03b5\u03c3\u03c4\u03c5\u03c0\u03cc\u03bb\u03b7, Al, Fe<\/td>\n | \n \u00af \u0391\u03c0\u03bf\u03c1\u03c1\u03cc\u03c6\u03b7\u03c3\u03b7 \u03a44<\/p>\n<\/td>\n<\/tr>\n | \n| \u0399\u03bd\u03c4\u03b5\u03c1\u03c6\u03b5\u03c1\u03cc\u03bd\u03b7-\u03b1, \u03b9\u03bd\u03c4\u03b5\u03c1\u03bb\u03b5\u03c5\u03ba\u03af\u03bd\u03b7-2<\/td>\n | \n \u00ad \u03a44 \u03ae \u00af \u03a43,\u03a44<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n 3.6. \u0386\u03bb\u03bb\u03b1 \u03b1\u03af\u03c4\u03b9\u03b1<\/b><\/h5>\n\u03a3\u03c4\u03bf\u03bd \u03c0\u03af\u03bd\u03b1\u03ba\u03b1 7<\/b> \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03b9\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b4\u03b9\u03ac\u03c6\u03bf\u03c1\u03b1 \u03b1\u03af\u03c4\u03b9\u03b1 \u03c0\u03bf\u03c5 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03bf\u03b4\u03b7\u03b3\u03ae\u03c3\u03bf\u03c5\u03bd \u03c3\u03c4\u03b7\u03bd \u03b1\u03bd\u03b5\u03cd\u03c1\u03b5\u03c3\u03b7 \u03c4\u03b9\u03bc\u03ce\u03bd TSH \u03c3\u03c4\u03b1 \u03cc\u03c1\u03b9\u03b1 \u03c4\u03bf\u03c5 \u03a5\u03a5\u0398 (11).<\/p>\n \u0395\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c5\u03c0\u2019 \u03cc\u03c8\u03b9\u03bd \u03cc\u03c4\u03b9 \u03b7 \u03a4SH \u03b5\u03af\u03bd\u03b1\u03b9 \u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b7 \u03c3\u03c4\u03b1 \u03c5\u03c0\u03ad\u03c1\u03b2\u03b1\u03c1\u03b1-\u03c0\u03b1\u03c7\u03cd\u03c3\u03b1\u03c1\u03ba\u03b1 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03c3\u03b5 \u03c3\u03c7\u03ad\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b1 \u03bd\u03bf\u03c1\u03bc\u03bf\u03b2\u03b1\u03c1\u03ae \u03ae \u03b1\u03b4\u03cd\u03bd\u03b1\u03c4\u03b1 \u03ac\u03c4\u03bf\u03bc\u03b1, \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c3\u03b5 \u03b1\u03c5\u03c4\u03ac \u03bc\u03b5 \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03ac \u0391\u03a4\u0391. \u0397 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ae \u03b1\u03c5\u03c4\u03ae \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03c1\u03ad\u03c8\u03b9\u03bc\u03b7 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b1\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1 \u03b2\u03ac\u03c1\u03bf\u03c5\u03c2 (33).<\/p>\n \u03a0\u03af\u03bd\u03b1\u03ba\u03b1\u03c2 7.<\/b> A\u03af\u03c4\u03b9\u03b1 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03c9\u03bd \u03c4\u03b9\u03bc\u03ce\u03bd TSH [\u03bc\u03b5\u03c4\u03b1\u03c6\u03c1\u03b1\u03c3\u03bc\u03ad\u03bd\u03bf \u03b1\u03c0\u03cc <\/b>Wartofsky et al <\/b>(11)].<\/p>\n\n \n\n\n\u0391\u03af\u03c4\u03b9\u03b1 <\/b><\/span><\/td>\n<\/tr>\n\n\u0398\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03af\u03c4\u03b9\u03b4\u03b1 Hashimoto
\n\u03a6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 (\u03c3\u03c4\u03b5\u03c1\u03bf\u03b5\u03b9\u03b4\u03ae, \u03bd\u03c4\u03bf\u03c0\u03b1\u03bc\u03af\u03bd\u03b7, \u03b9\u03c9\u03b4\u03b9\u03bf\u03cd\u03c7\u03b1, \u03b1\u03bc\u03b9\u03c9\u03b4\u03b1\u03c1\u03cc\u03bd\u03b7 \u03ba.\u03b1.)
\n\u039f\u03b9\u03ba. \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc \u03c5\u03c0\u03bf\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03c3\u03bc\u03bf\u03cd \u03c3\u03b5 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b7 \u03b7\u03bb\u03b9\u03ba\u03af\u03b1
\n\u039c\u03b7-\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae \u03bd\u03cc\u03c3\u03b7\u03c3\u03b7
\n\u039a\u03cd\u03b7\u03c3\u03b7
\n\u03a6\u03ac\u03c3\u03b7 \u03b1\u03bd\u03ac\u03bd\u03b7\u03c8\u03b7\u03c2 \u03b1\u03c0\u03cc \u03c5\u03c0\u03bf\u03be\u03b5\u03af\u03b1 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03af\u03c4\u03b9\u03b4\u03b1
\n\u0386\u03bb\u03bb\u03b1 \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03b1 \u03bd\u03bf\u03c3\u03ae\u03bc\u03b1\u03c4\u03b1
\n\u0395\u03c4\u03b5\u03c1\u03cc\u03c6\u03c5\u03bb\u03b1 \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1
\n\u0392\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03bc\u03b7-\u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ae TSH, \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03b1\u03c3\u03b7 \u03c3\u03c4\u03b7\u03bd TSH
\n\u039c\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 TSH
\n\u0391\u03bd\u03c4\u03af\u03c3\u03c4\u03b1\u03c3\u03b7 \u03c3\u03c4\u03b9\u03c2 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ad\u03c2 \u03bf\u03c1\u03bc\u03cc\u03bd\u03b5\u03c2
\n\u038c\u03b3\u03ba\u03bf\u03b9 \u03c5\u03c0\u03cc\u03c6\u03c5\u03c3\u03b7\u03c2 \u03b5\u03ba\u03ba\u03c1\u03af\u03bd\u03bf\u03bd\u03c4\u03b5\u03c2 TSH<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n4. \u0395\u03be\u03ad\u03bb\u03b9\u03be\u03b7 \u2013 \u03c6\u03c5\u03c3\u03b9\u03ba\u03ae \u03c0\u03bf\u03c1\u03b5\u03af\u03b1 \u03bd\u03cc\u03c3\u03bf\u03c5<\/b><\/h4>\n\u039f \u03a5\u03a5\u0398 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03b1\u03bd\u03b1\u03c3\u03c4\u03c1\u03ad\u03c8\u03b9\u03bc\u03b7 \u03ae \u03bc\u03b9\u03b1 \u03c0\u03c1\u03bf\u03bf\u03b4\u03b5\u03c5\u03c4\u03b9\u03ba\u03ac \u03b5\u03be\u03b5\u03bb\u03b9\u03c3\u03c3\u03cc\u03bc\u03b5\u03bd\u03b7 \u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7 \u03c0\u03c1\u03bf\u03c2 \u03c4\u03bf\u03bd \u03ad\u03ba\u03b4\u03b7\u03bb\u03bf \u03c5\u03c0\u03bf\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03c3\u03bc\u03cc. \u0397 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03c0\u03c1\u03cc\u03c3\u03bb\u03b7\u03c8\u03b7 \u03b9\u03c9\u03b4\u03af\u03bf\u03c5 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03b5\u03be\u03ad\u03bb\u03b9\u03be\u03b7\u03c2 \u03c3\u03b5 \u03ad\u03ba\u03b4\u03b7\u03bb\u03bf \u03c5\u03c0\u03bf\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03c3\u03bc\u03cc (14). \u0386\u03c4\u03bf\u03bc\u03b1 \u03c7\u03c9\u03c1\u03af\u03c2 \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03b7 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03af\u03c4\u03b9\u03b4\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b4\u03c5\u03bd\u03b1\u03c4\u03cc\u03bd \u03bd\u03b1 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03bf\u03c5\u03bd \u03b4\u03b9\u03b1\u03bb\u03b5\u03af\u03c0\u03bf\u03c5\u03c3\u03b1 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b5\u03c0\u03b9\u03c0\u03ad\u03b4\u03c9\u03bd \u03c4\u03b7\u03c2 TSH. \u03a4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03b5\u03c0\u03b1\u03bd\u03ad\u03c1\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b1 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03cc\u03c1\u03b9\u03b1 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03cc\u03c4\u03b1\u03bd \u03bf\u03b9 \u03c4\u03b9\u03bc\u03ad\u03c2 \u03c4\u03b7\u03c2 TSH \u03b2\u03c1\u03af\u03c3\u03ba\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf \u03c6\u03ac\u03c3\u03bc\u03b1 \u03c4\u03b9\u03bc\u03ce\u03bd 4,0-8,0 mU\/L, \u03b5\u03bd\u03ce \u03b7 \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b1\u03c5\u03c4\u03ae \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b1\u03bd \u03bf\u03b9 \u03c4\u03b9\u03bc\u03ad\u03c2 \u03b2\u03c1\u03af\u03c3\u03ba\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd 8,0-15,0 mU\/L.<\/p>\n \u0395\u03bd\u03b4\u03b9\u03b1\u03c6\u03ad\u03c1\u03bf\u03bd \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03b9\u03ac\u03b6\u03bf\u03c5\u03bd 4 \u03c0\u03c1\u03bf\u03bf\u03c0\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c3\u03c4\u03b9\u03c2 \u03bf\u03c0\u03bf\u03af\u03b5\u03c2 \u03b5\u03bb\u03ad\u03b3\u03c7\u03b8\u03b7\u03ba\u03b5 \u03bf \u03c1\u03c5\u03b8\u03bc\u03cc\u03c2 \u03bc\u03b5\u03c4\u03ac\u03c0\u03c4\u03c9\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03a5\u03a5\u0398 \u03c3\u03b5 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03c5\u03c0\u03bf\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03c3\u03bc\u03cc \u03c3\u03b5 \u03b7\u03bb\u03b9\u03ba\u03b9\u03c9\u03bc\u03ad\u03bd\u03b1. \u039f \u03c7\u03c1\u03cc\u03bd\u03bf\u03c2 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7\u03c2 \u03ba\u03c5\u03bc\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc 1-20 \u03ad\u03c4\u03b7, \u03bc\u03b5 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03bf \u03b1\u03c5\u03c4\u03cc\u03bd \u03c4\u03b7\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7\u03c2 Whickham. \u039f\u03b9 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03ae\u03c3\u03b5\u03b9\u03c2 \u03b1\u03c5\u03c4\u03ce\u03bd \u03c4\u03c9\u03bd \u03bc\u03b5\u03bb\u03b5\u03c4\u03ce\u03bd \u03c5\u03c0\u03bf\u03b4\u03b5\u03b9\u03ba\u03bd\u03cd\u03bf\u03c5\u03bd \u03cc\u03c4\u03b9 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03bc\u03b5 \u03a5\u03a5\u0398 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03bf\u03c5\u03bd \u03b5\u03c4\u03ae\u03c3\u03b9\u03bf \u03c1\u03c5\u03b8\u03bc\u03cc \u03c0\u03c1\u03bf\u03cc\u03b4\u03bf\u03c5 \u03c3\u03b5 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03c5\u03c0\u03bf\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03c3\u03bc\u03cc 2-3% (\u03a0\u03af\u03bd\u03b1\u03ba\u03b1\u03c2 8<\/b>). \u039f \u03c1\u03c5\u03b8\u03bc\u03cc\u03c2 \u03b1\u03c5\u03c4\u03cc\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf\u03c2 (4,3%) \u03c3\u03c4\u03b9\u03c2 \u03b3\u03c5\u03bd\u03b1\u03af\u03ba\u03b5\u03c2 \u03bc\u03b5 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03c4\u03b9\u03bc\u03ae TSH \u03ba\u03b1\u03b9 \u03b8\u03b5\u03c4\u03b9\u03ba\u03ac \u0391\u03a4\u0391 (14,34-36). \u0397 \u03b1\u03c1\u03c7\u03b9\u03ba\u03ae \u03c4\u03b9\u03bc\u03ae \u03c4\u03b7\u03c2 TSH \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03c4\u03bf\u03bd \u03c0\u03b9\u03bf \u03b9\u03c3\u03c7\u03c5\u03c1\u03cc \u03c0\u03c1\u03bf\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03cc \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1 \u03b5\u03be\u03ad\u03bb\u03b9\u03be\u03b7\u03c2 \u03c3\u03b5 \u03ad\u03ba\u03b4\u03b7\u03bb\u03bf \u03c5\u03c0\u03bf\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03c3\u03bc\u03cc. \u0386\u03bb\u03bb\u03bf\u03b9 \u03c0\u03c1\u03bf\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03bf\u03af \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 \u03c3\u03c5\u03bc\u03c0\u03c4\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03c5\u03c0\u03bf\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03c3\u03bc\u03bf\u03cd, \u03b7 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 \u03b2\u03c1\u03bf\u03b3\u03c7\u03bf\u03ba\u03ae\u03bb\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03b8\u03b5\u03c4\u03b9\u03ba\u03ce\u03bd \u0391\u03a4\u0391 \u03ba\u03b1\u03b8\u03ce\u03c2 \u03ba\u03b1\u03b9 \u03b7 \u03c7\u03b1\u03bc\u03b7\u03bb\u03ae (\u03ba\u03b1\u03c4\u03ce\u03c4\u03b5\u03c1\u03b1 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03cc\u03c1\u03b9\u03b1) \u03c4\u03b9\u03bc\u03ae \u03c4\u03b7\u03c2 FT4 (37). \u0395\u03bd\u03b4\u03b9\u03b1\u03c6\u03ad\u03c1\u03bf\u03bd \u03b5\u03cd\u03c1\u03b7\u03bc\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03b1\u03c0\u03bf\u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b5\u03c0\u03b9\u03c0\u03ad\u03b4\u03c9\u03bd \u03c4\u03b7\u03c2 TSH \u03c3\u03c4\u03b1 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03cc\u03c1\u03b9\u03b1 \u03c3\u03b5 \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc 37% \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u03ad\u03bd\u03b1 \u03bc\u03ad\u03c3\u03bf \u03c7\u03c1\u03bf\u03bd\u03b9\u03ba\u03cc \u03b4\u03b9\u03ac\u03c3\u03c4\u03b7\u03bc\u03b1 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7\u03c2 31,7 \u03bc\u03b7\u03bd\u03ce\u03bd. \u038c\u03c0\u03c9\u03c2 \u03ad\u03b4\u03b5\u03b9\u03be\u03b1\u03bd \u03b5\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd \u03c4\u03b1 \u03b5\u03c5\u03c1\u03ae\u03bc\u03b1\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03af\u03b4\u03b9\u03b1\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 7 \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03c4\u03c1\u03bf\u03c5\u03c2 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u03c0\u03bf\u03c5 \u03b5\u03bb\u03ad\u03b3\u03c7\u03b8\u03b7\u03ba\u03b1\u03bd \u03bc\u03b5 \u03b2\u03b1\u03b8\u03bc\u03b9\u03b4\u03c9\u03c4\u03ae \u03bc\u03bf\u03bd\u03bf- \u03ba\u03b1\u03b9 \u03c0\u03bf\u03bb\u03c5\u03c0\u03b1\u03c1\u03b1\u03b3\u03bf\u03bd\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03c3\u03c7\u03ad\u03c4\u03b9\u03c3\u03b7 \u03b7 \u03bc\u03cc\u03bd\u03b7 \u03c0\u03b1\u03c1\u03ac\u03bc\u03b5\u03c4\u03c1\u03bf\u03c2 \u03c0\u03bf\u03c5 \u03ad\u03c7\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03b5\u03c0\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03c3\u03c4\u03b7\u03bd \u03b5\u03be\u03ad\u03bb\u03b9\u03be\u03b7 \u03c4\u03bf\u03c5 \u03a5\u03a5\u0398 \u03c3\u03b5 \u03ad\u03ba\u03b4\u03b7\u03bb\u03bf \u03c5\u03c0\u03bf\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03c3\u03bc\u03cc, \u03ae\u03c4\u03b1\u03bd \u03b7 \u03b1\u03c1\u03c7\u03b9\u03ba\u03ae \u03c4\u03b9\u03bc\u03ae \u03c4\u03b7\u03c2 TSH. \u0391\u03bd\u03c4\u03af\u03b8\u03b5\u03c4\u03b1, \u03c0\u03bf\u03bb\u03cd \u03bc\u03b9\u03ba\u03c1\u03cc\u03c4\u03b5\u03c1\u03b7 \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03b5\u03af\u03c7\u03b1\u03bd \u03b7 \u03c4\u03b9\u03bc\u03ae \u03c4\u03b7\u03c2 FT4, \u03c4\u03c9\u03bd \u03b1\u03bd\u03c4\u03b9-TPO abs \u03ba\u03b1\u03b9 \u03b7 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 \u03b2\u03c1\u03bf\u03b3\u03c7\u03bf\u03ba\u03ae\u03bb\u03b7\u03c2 \u03ae \u03c3\u03c5\u03bc\u03c0\u03c4\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd (\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 9<\/b>) (37).<\/p>\n \u03a0\u03af\u03bd\u03b1\u03ba\u03b1\u03c2 8<\/b>.<\/b> \u039c\u03b5\u03c4\u03ac\u03c0\u03c4\u03c9\u03c3\u03b7 \u03c5\u03c0\u03bf\u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03bf\u03cd \u03c5\u03c0\u03bf\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03c3\u03bc\u03bf\u03cd \u03c3\u03b5 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b7\u03bb\u03b9\u03ba\u03b9\u03c9\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2 (\u03c0\u03c1\u03bf\u03bf\u03c0\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2).<\/p>\n\n\n\n| \u00a0<\/span><\/td>\n | \u0392\u03b9\u03b2\u03bb\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1<\/b><\/span><\/td>\n | \n \u0388\u03c4\u03bf\u03c2<\/b><\/span><\/p>\n<\/td>\n | \n \u03a0\u03c1\u03bf\u03ad\u03bb\u03b5\u03c5\u03c3\u03b7<\/b><\/span><\/p>\n<\/td>\n | \n \u039d\u03bf \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd<\/b><\/span><\/p>\n<\/td>\n | \n \u0394\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1<\/b><\/span><\/p>\n<\/td>\n | \n \u0388\u03ba\u03b2\u03b1\u03c3\u03b7 \u03a5\u03a0\u039f –<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n\n| \n 1<\/p>\n<\/td>\n | Gordin A et al (126)<\/td>\n | \n 1981<\/p>\n<\/td>\n | \n \u03a6\u03b9\u03bd\u03bb\u03b1\u03bd\u03b4\u03af\u03b1<\/p>\n<\/td>\n | \n 8<\/p>\n<\/td>\n | \n 3 – 9 \u03c7\u03c1.<\/p>\n<\/td>\n | \n 88%<\/p>\n<\/td>\n<\/tr>\n | \n| \n 2<\/p>\n<\/td>\n | Parle J et al<\/td>\n | \n 1991<\/p>\n<\/td>\n | \n \u0392\u03c1\u03b5\u03c4\u03b1\u03bd\u03af\u03b1<\/p>\n<\/td>\n | \n 73<\/p>\n<\/td>\n | \n \u2265 1 \u03c7\u03c1.<\/p>\n<\/td>\n | \n 18%<\/p>\n<\/td>\n<\/tr>\n | \n| \n 3<\/p>\n<\/td>\n | Vanderpump M et al (22)<\/td>\n | \n 1995<\/p>\n<\/td>\n | \n \u0392\u03c1\u03b5\u03c4\u03b1\u03bd\u03af\u03b1<\/p>\n<\/td>\n | \n 942 \u2640<\/p>\n<\/td>\n | \n 20 \u03c7\u03c1.<\/p>\n<\/td>\n | \n 2,6% (- Abs), 4,3 (+ Abs)<\/p>\n<\/td>\n<\/tr>\n | \n| \n 4<\/p>\n<\/td>\n | Huber G et al<\/td>\n | \n 1997<\/p>\n<\/td>\n | \n \u0395\u03bb\u03b2\u03b5\u03c4\u03af\u03b1<\/p>\n<\/td>\n | \n 154 \u2640<\/p>\n<\/td>\n | \n 10 \u03c7\u03c1.<\/p>\n<\/td>\n | \n 4,3%<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
\n![\"10.17image9\"](\"https:\/\/e-endocrinology.gr\/wp-content\/uploads\/2015\/02\/10.17image9.jpg\") <\/p>\n
<\/p>\n \u0395\u03b9\u03ba\u03cc\u03bd\u03b1 9. <\/b>\u0395\u03be\u03ad\u03bb\u03b9\u03be\u03b7 \u03c5\u03c0\u03bf\u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03bf\u03cd \u03c5\u03c0\u03bf\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03c3\u03bc\u03bf\u03cd \u03c3\u03b5 \u03ad\u03ba\u03b4\u03b7\u03bb\u03bf \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03b4\u03b9\u03ac\u03c6\u03bf\u03c1\u03bf\u03c5\u03c2 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2 Diez JJ et al (37).<\/p>\n
\n5. \u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae – \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1 \u03a5\u03a5\u0398<\/b><\/h4>\n5.1. \u0395\u03be\u03ad\u03bb\u03b9\u03be\u03b7 \u03c3\u03b5 \u03ad\u03ba\u03b4\u03b7\u03bb\u03bf-\u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03c5\u03c0\u03bf\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03c3\u03bc\u03cc<\/b><\/h5>\n \u038c\u03c0\u03c9\u03c2 \u03ae\u03b4\u03b7 \u03b1\u03bd\u03b1\u03c6\u03ad\u03c1\u03b8\u03b7\u03ba\u03b5 \u03c3\u03b5 \u03ad\u03bd\u03b1 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03bf \u03a5\u03a5\u0398 \u03b5\u03be\u03b5\u03bb\u03af\u03c3\u03c3\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03ad\u03ba\u03b4\u03b7\u03bb\u03bf \u03c5\u03c0\u03bf\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03c3\u03bc\u03cc. \u0399\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03ac\u03bd\u03c9 \u03c4\u03c9\u03bd 55 \u03b5\u03c4\u03ce\u03bd \u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2 \u03c5\u03c0\u03bf\u03bb\u03bf\u03b3\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c9\u03c2 \u03ba\u03b1\u03b9 8% \u03b1\u03bd\u03ac \u03ad\u03c4\u03bf\u03c2 (28).<\/p>\n 5.2. \u03a3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1 \u03a5\u03a5\u0398<\/b><\/h5>\nH \u03b1\u03c0\u03cc\u03c6\u03b1\u03c3\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03ce\u03c0\u03b9\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03a5\u03a5\u0398 \u03b2\u03b1\u03c3\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03ac \u03c3\u03c4\u03b7\u03bd \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03c3\u03c5\u03bc\u03c0\u03c4\u03c9\u03bc\u03b1\u03c4\u03bf\u03bb\u03bf\u03b3\u03af\u03b1\u03c2 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5. \u039a\u03b1\u03c4\u03ac \u03ba\u03b1\u03b9\u03c1\u03bf\u03cd\u03c2 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b1\u03bd\u03b1\u03c0\u03c4\u03c5\u03c7\u03b8\u03b5\u03af \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03c4\u03b1\u03b8\u03b5\u03af \u03b4\u03b9\u03ac\u03c6\u03bf\u03c1\u03b5\u03c2 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf\u03b9 \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd \u03c3\u03b7\u03bc\u03b5\u03af\u03c9\u03bd-\u03c3\u03c5\u03bc\u03c0\u03c4\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03c4\u03bf\u03c5 \u03a5\u03a5\u0398 \u03ae \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03bd\u03bf\u03b7\u03c4\u03b9\u03ba\u03ae\u03c2 \u03ba\u03b1\u03b9 \u03c8\u03c5\u03c7\u03b9\u03ba\u03ae\u03c2 \u03c5\u03b3\u03b5\u03af\u03b1\u03c2 \u03ae \u03c4\u03b7\u03c2 \u03c0\u03bf\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03b6\u03c9\u03ae\u03c2 \u03b1\u03c5\u03c4\u03ce\u03bd \u03c4\u03c9\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd. \u0388\u03bd\u03b1 \u03b5\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03bf \u03c0\u03bf\u03c5 \u03ad\u03c7\u03b5\u03b9 \u03bc\u03b5\u03c4\u03b1\u03b2\u03ac\u03bb\u03bb\u03b5\u03b9 \u03c4\u03b7\u03bd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03c4\u03bf\u03c5 \u03c5\u03c0\u03bf\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03c3\u03bc\u03bf\u03cd \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf \u03b3\u03b5\u03b3\u03bf\u03bd\u03cc\u03c2 \u03cc\u03c4\u03b9 \u03c4\u03b1 \u03c4\u03b5\u03bb\u03b5\u03c5\u03c4\u03b1\u03af\u03b1 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03b4\u03b9\u03b1\u03b3\u03b9\u03b3\u03bd\u03ce\u03c3\u03ba\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03c0\u03bf\u03bb\u03cd \u03c0\u03c1\u03ce\u03b9\u03bc\u03bf \u03c3\u03c4\u03ac\u03b4\u03b9\u03bf, \u03b5\u03bd\u03ce \u03c0\u03b1\u03bb\u03b1\u03b9\u03cc\u03c4\u03b5\u03c1\u03b1 \u03b7 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03b2\u03b1\u03c3\u03b9\u03b6\u03cc\u03c4\u03b1\u03bd \u03c3\u03c4\u03b9\u03c2 \u03b5\u03ba\u03b4\u03b7\u03bb\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c4\u03b7\u03c2 \u03c3\u03bf\u03b2\u03b1\u03c1\u03ae\u03c2 \u03ba\u03b1\u03b9 \u03bc\u03b1\u03ba\u03c1\u03bf\u03c7\u03c1\u03cc\u03bd\u03b9\u03b1\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5. \u0391\u03c5\u03c4\u03cc \u03c3\u03c4\u03b7\u03bd \u03c0\u03c1\u03ac\u03be\u03b7 \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03bf\u03b9 \u03c0\u03b1\u03bb\u03b9\u03ad\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf\u03b9 \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c4\u03b5\u03bb\u03ad\u03c3\u03c6\u03bf\u03c1\u03b5\u03c2. \u0394\u03cd\u03bf \u03b5\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1 \u03c0\u03bf\u03c5 \u03ba\u03b1\u03b8\u03b9\u03c3\u03c4\u03bf\u03cd\u03bd \u03b4\u03c5\u03c3\u03c7\u03b5\u03c1\u03ae \u03c4\u03b7\u03bd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03c1\u03ce\u03c4\u03bf\u03bd \u03cc\u03c4\u03b9 \u03c3\u03b7\u03bc\u03b5\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1 \u03c5\u03c0\u03bf\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03c3\u03bc\u03bf\u03cd \u03b1\u03bd\u03b5\u03c5\u03c1\u03af\u03c3\u03ba\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03ac \u03c3\u03b5 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03bc\u03b5 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03ae \u03c4\u03bf\u03be\u03b9\u03ba\u03cc \u03b1\u03b4\u03ad\u03bd\u03c9\u03bc\u03b1 (38-40) \u03ba\u03b1\u03b9 \u03b4\u03b5\u03cd\u03c4\u03b5\u03c1\u03bf\u03bd \u03b7 \u03b1\u03bb\u03bb\u03b7\u03bb\u03bf\u03b5\u03c0\u03b9\u03ba\u03ac\u03bb\u03c5\u03c8\u03b7 \u03c3\u03c5\u03bc\u03c0\u03c4\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03c8\u03c5\u03c7\u03b9\u03ba\u03ae \u03c3\u03c6\u03b1\u03af\u03c1\u03b1 (\u03c0.\u03c7 \u03ba\u03b1\u03c4\u03ac\u03b8\u03bb\u03b9\u03c8\u03b7) \u03bc\u03b5 \u03b5\u03ba\u03b5\u03af\u03bd\u03b1 \u03c4\u03bf\u03c5 \u03c5\u03c0\u03bf\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03c3\u03bc\u03bf\u03cd (41,42). \u03a3\u03c4\u03b7\u03bd \u03c4\u03b5\u03bb\u03b5\u03c5\u03c4\u03b1\u03af\u03b1 \u03b4\u03b5 \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03b7 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b5\u03c1\u03b7 \u03b1\u03bd\u03b5\u03cd\u03c1\u03b5\u03c3\u03b7 \u03b1\u03bd\u03c4\u03b9\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd (20 vs 5%) \u03b4\u03c5\u03c3\u03c7\u03b5\u03c1\u03b1\u03af\u03bd\u03b5\u03b9 \u03b5\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd \u03c4\u03b7 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b9\u03ba\u03ae \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 (43).<\/p>\n \u03a7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03ce\u03bd\u03c4\u03b1\u03c2 \u03ad\u03bd\u03b1 \u03ac\u03b8\u03c1\u03bf\u03b9\u03c3\u03bc\u03b1 14 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ce\u03bd \u03c3\u03c5\u03bc\u03c0\u03c4\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd-\u03c3\u03b7\u03bc\u03b5\u03af\u03c9\u03bd \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae\u03c2 \u03c5\u03c0\u03bf\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2 \u03bf\u03b9 Zulewski \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bd. \u03b2\u03c1\u03ae\u03ba\u03b1\u03bd \u03bc\u03b9\u03b1 \u03ba\u03b1\u03bb\u03ae \u03c3\u03c5\u03c3\u03c7\u03ad\u03c4\u03b9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u2018score\u2019 \u03bc\u03b5 \u03c4\u03b7\u03bd FT4 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd TSH \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03a5\u03a5\u0398 (44). \u03a3\u03b5 \u03bd\u03b5\u03cc\u03c4\u03b5\u03c1\u03b7 \u03c9\u03c3\u03c4\u03cc\u03c3\u03bf \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd 1423 \u03b3\u03c5\u03bd\u03b1\u03b9\u03ba\u03ce\u03bd \u03b7\u03bb\u03b9\u03ba\u03af\u03b1\u03c2 16-75 \u03b5\u03c4\u03ce\u03bd \u03c4\u03cc\u03c3\u03bf \u03bf \u03b4\u03b5\u03af\u03ba\u03c4\u03b7\u03c2 \u2018short form 36\u2019 (SF-36) \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03bf \u03b4\u03b5\u03af\u03ba\u03c4\u03b7\u03c2 \u03ba\u03b1\u03bb\u03ae\u03c2 \u03c8\u03c5\u03c7\u03b9\u03ba\u03ae\u03c2 \u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7\u03c2 (psychological general well being index-PGWI) \u03c0\u03bf\u03c5 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03ae\u03b8\u03b7\u03ba\u03b1\u03bd \u03c9\u03c2 \u03b4\u03b5\u03af\u03ba\u03c4\u03b5\u03c2 \u03c0\u03bf\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03b6\u03c9\u03ae\u03c2 \u03c3\u03c7\u03b5\u03c4\u03b9\u03b6\u03cc\u03bc\u03b5\u03bd\u03b7\u03c2 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03ba\u03b1\u03bb\u03ae \u03c5\u03b3\u03b5\u03af\u03b1 \u03b4\u03b5 \u03b4\u03b9\u03b1\u03c0\u03af\u03c3\u03c4\u03c9\u03c3\u03b1\u03bd \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03ad\u03c2 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03b1\u03c4\u03cc\u03bc\u03c9\u03bd \u03bc\u03b5 \u03ae \u03c7\u03c9\u03c1\u03af\u03c2 \u03a5\u03a5\u0398 (\u03c4\u03b9\u03bc\u03ae TSH>4,0 mU\/L) (45).<\/p>\n \u0397 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 \u03ae \u03bc\u03b7 \u03c3\u03c5\u03bc\u03c0\u03c4\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03a5\u03a5\u0398 \u03b5\u03ba\u03c4\u03b9\u03bc\u03ae\u03b8\u03b7\u03ba\u03b5 \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03b4\u03cd\u03bf \u03ac\u03bb\u03bb\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03bc\u03b5 \u03c7\u03c1\u03bf\u03bd\u03b9\u03ba\u03ae \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03ac 18 \u03b5\u03c4\u03ce\u03bd. \u03a3\u03c4\u03b7\u03bd \u03c0\u03c1\u03ce\u03c4\u03b7 \u03bf\u03b9 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03a5\u03a5\u0398 \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03b6\u03b1\u03bd \u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b7 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c5\u03c0\u03bf\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03c3\u03c5\u03bc\u03c0\u03c4\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03c3\u03c5\u03b3\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5 \u03c4\u03bf\u03c5\u03c2 \u03b9\u03b4\u03af\u03bf\u03c5 \u03c6\u03cd\u03bb\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03b7\u03bb\u03b9\u03ba\u03af\u03b1\u03c2 \u03b5\u03c5\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03bc\u03ac\u03c1\u03c4\u03c5\u03c1\u03b5\u03c2 (46). \u03a3\u03c4\u03b7 \u03b4\u03b5\u03cd\u03c4\u03b5\u03c1\u03b7 \u03b2\u03c1\u03ad\u03b8\u03b7\u03ba\u03b5 \u03cc\u03c4\u03b9 \u03c4\u03b1 \u03c0\u03b9\u03bf \u03c3\u03c5\u03c7\u03bd\u03ac \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1 \u03c0\u03bf\u03c5 \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03b6\u03b1\u03bd \u03bf\u03b9 \u03b3\u03c5\u03bd\u03b1\u03af\u03ba\u03b5\u03c2 \u03bc\u03b5 \u03a5\u03a5\u0398 \u03ae\u03c4\u03b1\u03bd \u03c4\u03bf \u03b1\u03af\u03c3\u03b8\u03b7\u03bc\u03b1 \u03ba\u03cc\u03c0\u03c9\u03c3\u03b7\u03c2 (83%) \u03ba\u03b1\u03b9 \u03b7 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b2\u03ac\u03c1\u03bf\u03c5\u03c2 \u03c3\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 (80%) (47).<\/p>\n \u03a3\u03b5 \u03bc\u03b9\u03b1 \u03c0\u03c1\u03cc\u03c3\u03c6\u03b1\u03c4\u03b7 \u03c4\u03ad\u03bb\u03bf\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7, \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03ad\u03c7\u03c1\u03b9 \u03c3\u03c4\u03b9\u03b3\u03bc\u03ae\u03c2 \u03b7 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03c0\u03c1\u03bf\u03bf\u03c0\u03c4\u03b9\u03ba\u03ae \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03b9\u03b1\u03ba\u03ae \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03b5\u03be\u03ad\u03bb\u03b9\u03be\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03a5\u03a5\u0398, \u03bc\u03b5\u03c4\u03b1\u03be\u03cd 3996 \u03b1\u03c4\u03cc\u03bc\u03c9\u03bd \u03ac\u03bd\u03c9 \u03c4\u03c9\u03bd 65 \u03b5\u03c4\u03ce\u03bd \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03ae\u03b8\u03b7\u03ba\u03b1\u03bd \u03b3\u03b9\u03b1 4 \u03ad\u03c4\u03b7 \u03b4\u03b9\u03b1\u03c0\u03b9\u03c3\u03c4\u03ce\u03b8\u03b7\u03ba\u03b1\u03bd \u03c4\u03b1 \u03b1\u03ba\u03cc\u03bb\u03bf\u03c5\u03b8\u03b1: \u03b5\u03c0\u03b9\u03bc\u03bf\u03bd\u03ae \u03c4\u03bf\u03c5 \u03a5\u03a5\u0398 \u03c3\u03b5 \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc 56% \u03c3\u03c4\u03b1 2 \u03ba\u03b1\u03b9 4 \u03ad\u03c4\u03b7, \u03b7 \u03cd\u03c6\u03b5\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03a5\u03a5\u0398 \u03c3\u03c4\u03b1 2 \u03ad\u03c4\u03b7 \u03ae\u03c4\u03b1\u03bd \u03c0\u03b9\u03bf \u03c3\u03c5\u03c7\u03bd\u03ae \u03c3\u03c4\u03b1 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03bc\u03b5 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 TSH \u03bc\u03b5\u03c4\u03b1\u03be\u03cd 4,5-6,9 mU\/L (46% vs 10% \u03b5\u03ba\u03b5\u03af\u03bd\u03c9\u03bd \u03bc\u03b5 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 TSH 7,0-8,9 mU\/L \u03ba\u03b1\u03b9 7% \u03b5\u03ba\u03b5\u03af\u03bd\u03c9\u03bd \u03c0\u03bf\u03c5 \u03b5\u03af\u03c7\u03b1\u03bd \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 > 10,0 mU\/L, p<0,001). \u0395\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd \u03b7 \u03b1\u03c0\u03bf\u03c5\u03c3\u03af\u03b1 TPOAbs \u03c3\u03c5\u03bd\u03bf\u03b4\u03b5\u03cd\u03bf\u03bd\u03c4\u03b1\u03bd \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b5\u03c1\u03b1 \u03bc\u03b5 \u03c5\u03c6\u03ad\u03c3\u03b5\u03b9\u03c2 \u03c4\u03bf\u03c5 \u03a5\u03a5\u0398 (48 vs 15% \u03b5\u03ba\u03b5\u03af\u03bd\u03c9\u03bd \u03bc\u03b5 \u03b8\u03b5\u03c4\u03b9\u03ba\u03ac TPOAbs, p<0,001). \u03a5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03b7\u03c2 TSH \u03ba\u03b1\u03b9 \u03b8\u03b5\u03c4\u03b9\u03ba\u03ac TPOAbs \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03bf\u03cd\u03bd \u03b1\u03bd\u03b5\u03be\u03ac\u03c1\u03c4\u03b7\u03c4\u03bf\u03c5\u03c2 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2 \u03bc\u03b7 \u03cd\u03c6\u03b5\u03c3\u03b7\u03c2 (p<0,05) (17). \u03a4\u03b9\u03bc\u03ad\u03c2 TSH=10,0 mU\/L \u03ae \u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03ae\u03c4\u03b1\u03bd \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03b1\u03bd\u03b5\u03be\u03ac\u03c1\u03c4\u03b7\u03c4\u03bf\u03c2 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c0\u03c1\u03bf\u03cc\u03b4\u03bf\u03c5 \u03c3\u03b5 \u03ad\u03ba\u03b4\u03b7\u03bb\u03bf \u03c5\u03c0\u03bf\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03c3\u03bc\u03cc (p<0,05) (17). \u0397 \u03bc\u03b5\u03c4\u03ac\u03c0\u03c4\u03c9\u03c3\u03b7 \u03c3\u03b5 \u03b5\u03c5\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03c3\u03bc\u03cc \u03ae \u03c5\u03c0\u03bf\u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03c5\u03c0\u03bf\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b4\u03b9\u03c3\u03bc\u03cc \u03ae\u03c4\u03b1\u03bd \u03c3\u03c5\u03c7\u03bd\u03ae \u03c3\u03c4\u03b1 2 \u03ba\u03b1\u03b9 4 \u03ad\u03c4\u03b7, \u03b5\u03bd\u03ce \u03c4\u03ad\u03bb\u03bf\u03c2 \u03b7 \u03b7\u03bb\u03b9\u03ba\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03bf \u03c6\u03cd\u03bb\u03bf \u03b4\u03b5\u03bd \u03b5\u03c0\u03b7\u03c1\u03ad\u03b1\u03b6\u03b1\u03bd \u03b1\u03c5\u03c4\u03ae \u03c4\u03b7 \u03bc\u03b5\u03c4\u03ac\u03c0\u03c4\u03c9\u03c3\u03b7 (48).<\/p>\n \u03a3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b1\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03b7 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 \u03c3\u03b7\u03bc\u03b5\u03af\u03c9\u03bd\u2013\u03c3\u03c5\u03bc\u03c0\u03c4\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03c3\u03b5 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2 \u03a5\u03a5\u0398 \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03b5\u03b9 \u03b1\u03bc\u03c6\u03b9\u03bb\u03b5\u03b3\u03cc\u03bc\u03b5\u03bd\u03b7. \u0395\u03af\u03bd\u03b1\u03b9 \u03b4\u03cd\u03c3\u03ba\u03bf\u03bb\u03b7 \u03b7 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b4\u03b9\u03ac\u03ba\u03c1\u03b9\u03c3\u03b7 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03b5\u03c5\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03ba\u03b1\u03b9 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03bc\u03b5 \u03a5\u03a5\u0398. \u0395\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd \u03c0\u03bf\u03bb\u03bb\u03ac \u03b1\u03c0\u03cc \u03c4\u03b1 \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1-\u03c3\u03b7\u03bc\u03b5\u03af\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b7 \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03ba\u03b1\u03b9 \u03b1\u03bd\u03b5\u03c5\u03c1\u03af\u03c3\u03ba\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03ac \u03c3\u03b5 \u03ac\u03bb\u03bb\u03b5\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c3\u03b5 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7\u03c2 \u03b7\u03bb\u03b9\u03ba\u03af\u03b1\u03c2, \u03c3\u03c4\u03b1 \u03bf\u03c0\u03bf\u03af\u03b1 \u03b5\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd \u03bf\u03b9 \u03c4\u03c5\u03c0\u03b9\u03ba\u03ad\u03c2 \u03b5\u03ba\u03b4\u03b7\u03bb\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c4\u03bf\u03c5 \u03c5\u03c0\u03bf\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03c3\u03bc\u03bf\u03cd \u03b1\u03bd\u03b5\u03c5\u03c1\u03af\u03c3\u03ba\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bb\u03b9\u03b3\u03cc\u03c4\u03b5\u03c1\u03bf \u03c3\u03c5\u03c7\u03bd\u03ac \u03ba\u03b1\u03b9 \u03cc\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03b1\u03c0\u03bf\u03b4\u03af\u03b4\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03c3\u03b5 \u03c3\u03c5\u03bd\u03bf\u03c3\u03b7\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1, \u03ba\u03b1\u03c4\u03ac\u03b8\u03bb\u03b9\u03c8\u03b7, \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03bd\u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03ae \u03c3\u03c4\u03b7 \u03af\u03b4\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b7\u03bb\u03b9\u03ba\u03af\u03b1 (49,50). \u03a4\u03ad\u03bb\u03bf\u03c2 \u03ad\u03bd\u03b1 \u03c3\u03b7\u03bc\u03b5\u03af\u03bf \u03c0\u03bf\u03c5 \u03c7\u03c1\u03ae\u03b6\u03b5\u03b9 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b7\u03c2 \u03c0\u03c1\u03bf\u03c3\u03bf\u03c7\u03ae\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03bf\u03b9 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03bf\u03c5 \u03b1\u03bd\u03b1\u03c6\u03ad\u03c1\u03bf\u03c5\u03bd \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b1 \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03b9\u03b4\u03af\u03c9\u03c2 \u03cc\u03c4\u03b1\u03bd \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b2\u03c1\u03b1\u03c7\u03cd \u03c7\u03c1\u03bf\u03bd\u03b9\u03ba\u03cc \u03b4\u03b9\u03ac\u03c3\u03c4\u03b7\u03bc\u03b1, \u03ad\u03c7\u03bf\u03c5\u03bd \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03bd\u03b1 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03c3\u03bf\u03c5\u03bd \u03ad\u03ba\u03b4\u03b7\u03bb\u03b7 \u03bd\u03cc\u03c3\u03bf (17).<\/p>\n 5.3. \u039c\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03ba\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ad\u03c2 \u03b5\u03c0\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03a5\u03a5\u0398<\/b><\/h5>\n\u038c\u03c0\u03c9\u03c2 \u03ad\u03c7\u03b5\u03b9 \u03c6\u03b1\u03bd\u03b5\u03af \u03b1\u03c0\u03cc \u03c0\u03bf\u03bb\u03bb\u03ad\u03c2 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03bf \u03bc\u03b1\u03ba\u03c1\u03bf\u03c7\u03c1\u03cc\u03bd\u03b9\u03bf\u03c2 \u03bc\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03cc\u03bc\u03b5\u03bd\u03bf\u03c2 \u03a5\u03a5\u0398 \u03b4\u03c5\u03bd\u03b1\u03c4\u03cc\u03bd \u03bd\u03b1 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03ba\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ad\u03c2 \u03b5\u03c0\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 (51-53) \u03cc\u03c0\u03c9\u03c2 \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c0\u03b1\u03c1\u03b1\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03ac \u03c3\u03c4\u03b7\u03bd \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 10<\/b>. \u039f\u03b9 \u03b5\u03c0\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03b1\u03c5\u03c4\u03ad\u03c2 \u03b4\u03c5\u03bd\u03b1\u03c4\u03cc\u03bd \u03bd\u03b1 \u03b1\u03c5\u03be\u03ac\u03bd\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ae \u03bd\u03bf\u03c3\u03b7\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03b8\u03bd\u03b7\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1.<\/p>\n \u03a3\u03c4\u03b7 \u03b3\u03bd\u03c9\u03c3\u03c4\u03ae \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 Colorado \u03bf\u03b9 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03a5\u03a5\u0398 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03bf\u03c5\u03bd \u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03bf\u03bb\u03b9\u03ba\u03ae\u03c2 \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2 \u03c3\u03b5 \u03c3\u03c7\u03ad\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03bf\u03c5\u03c2 \u03b5\u03c5\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03bf\u03cd\u03c2 (224 \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 216 mg\/dl) (17). \u0395\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd \u03b1\u03c1\u03ba\u03b5\u03c4\u03ad\u03c2 \u03c4\u03c5\u03c7\u03b1\u03b9\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b4\u03b5\u03af\u03be\u03b5\u03b9 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b5\u03c0\u03b9\u03c0\u03ad\u03b4\u03c9\u03bd \u03c4\u03b7\u03c2 LDL-\u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2 \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7\u03bd \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 LT4. \u03a9\u03c3\u03c4\u03cc\u03c3\u03bf \u03c3\u03c4\u03b9\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03b4\u03b5\u03bd \u03ad\u03b3\u03b9\u03bd\u03b5 \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03b9\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03ac\u03c4\u03c9\u03bd \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03c4\u03b9\u03bc\u03ae \u03c4\u03b7\u03c2 TSH \u03c3\u03c4\u03bf \u03c6\u03ac\u03c3\u03bc\u03b1 \u03c4\u03c9\u03bd \u03c4\u03b9\u03bc\u03ce\u03bd \u03c4\u03bf\u03c5\u03a5\u03a5\u0398 (5 – 10 mU\/L). \u03a3\u03b5 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ae \u03bc\u03b5\u03c4\u03b1-\u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 \u03c0\u03bf\u03c5 \u03c0\u03b5\u03c1\u03b9\u03b5\u03bb\u03ac\u03bc\u03b2\u03b1\u03bd\u03b5 13 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03b4\u03b9\u03b1\u03c0\u03b9\u03c3\u03c4\u03ce\u03b8\u03b7\u03ba\u03b5 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03cc \u03cc\u03c6\u03b5\u03bb\u03bf\u03c2 \u03c3\u03c4\u03b7 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b7 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 LT4 (54). \u03a3\u03b5 \u03b3\u03b5\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b3\u03c1\u03b1\u03bc\u03bc\u03ad\u03c2 \u03b1\u03c5\u03c4\u03cc \u03c0\u03bf\u03c5 \u03b5\u03be\u03ac\u03b3\u03b5\u03c4\u03b1\u03b9 \u03c9\u03c2 \u03bc\u03ae\u03bd\u03c5\u03bc\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03b4\u03b9\u03ac\u03c6\u03bf\u03c1\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03bf \u03a5\u03a5\u0398 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03b4\u03c5\u03c3\u03bb\u03b9\u03c0\u03b9\u03b4\u03b1\u03b9\u03bc\u03af\u03b1, \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03bc\u03b5 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bf\u03bb\u03b9\u03ba\u03ae\u03c2 \u03ba\u03b1\u03b9 LDL-\u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2, \u03b5\u03bd\u03ce \u03c4\u03b1 \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1 \u03b1\u03bd\u03b1\u03c6\u03bf\u03c1\u03b9\u03ba\u03ac \u03bc\u03b5 \u03c4\u03b7\u03bd HDL-\u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7, \u03c4\u03b1 \u03c4\u03c1\u03b9\u03b3\u03bb\u03c5\u03ba\u03b5\u03c1\u03af\u03b4\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd Lp(a) \u03b4\u03b5 \u03b4\u03b5\u03af\u03c7\u03bd\u03bf\u03c5\u03bd \u03c3\u03b1\u03c6\u03ae \u03c3\u03c5\u03c3\u03c7\u03ad\u03c4\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03a5\u03a5\u0398 (53, 55, 56). \u0395\u03bd\u03ce \u03b5\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd, \u03c3\u03b5 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ae \u03b1\u03bd\u03b1\u03c3\u03ba\u03cc\u03c0\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 2004 \u03b4\u03b5 \u03b2\u03c1\u03ad\u03b8\u03b7\u03ba\u03b5 \u03cc\u03c6\u03b5\u03bb\u03bf\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 LT4 (3). \u0391\u03c5\u03c4\u03cc \u03c9\u03c3\u03c4\u03cc\u03c3\u03bf \u03c0\u03bf\u03c5 \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c0\u03b9\u03bf \u03c3\u03b1\u03c6\u03ad\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03b7 \u03bb\u03b9\u03c0\u03b9\u03b4\u03b1\u03b9\u03bc\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b9\u03bf \u03b5\u03c0\u03b7\u03c1\u03b5\u03b1\u03c3\u03bc\u03ad\u03bd\u03b7 \u03c3\u03b5 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03bc\u03b5 \u03c3\u03bf\u03b2\u03b1\u03c1\u03cc\u03c4\u03b5\u03c1\u03bf \u03a5\u03a5\u0398 (TSH > 10 mU\/L), \u03c3\u03c4\u03bf\u03c5\u03c2 \u03ba\u03b1\u03c0\u03bd\u03b9\u03c3\u03c4\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03bf\u03c5 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03bf\u03c5\u03bd \u03c3\u03c5\u03b3\u03c7\u03c1\u03cc\u03bd\u03c9\u03c2 \u03b9\u03bd\u03c3\u03bf\u03c5\u03bb\u03b9\u03bd\u03bf\u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03b1\u03c3\u03b7 (53, 55, 56).<\/p>\n
\n![\"10.17image10\"](\"https:\/\/e-endocrinology.gr\/wp-content\/uploads\/2015\/02\/10.17image10.jpg\") <\/p>\n
\u00a0<\/b><\/p>\n \u0395\u03b9\u03ba\u03cc\u03bd\u03b1<\/b> <\/b>10<\/b>. <\/b>\u03a3\u03c7\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b1\u03c0\u03b5\u03b9\u03ba\u03cc\u03bd\u03b9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03cc\u03bd\u03c4\u03c9\u03bd \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03bc\u03b1\u03ba\u03c1\u03bf\u03c7\u03c1\u03cc\u03bd\u03b9\u03bf \u03bc\u03b7-\u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03c9\u03c0\u03b9\u03b6\u03cc\u03bc\u03b5\u03bd\u03bf \u03a5\u03a5\u0398.<\/p>\n
\n \u038c\u03c3\u03bf\u03bd \u03b1\u03c6\u03bf\u03c1\u03ac \u03c3\u03b5 \u03ac\u03bb\u03bb\u03bf\u03c5\u03c2 \u2018\u03bc\u03b7 \u03c0\u03b1\u03c1\u03b1\u03b4\u03bf\u03c3\u03b9\u03b1\u03ba\u03bf\u03cd\u03c2\u2019 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u03b3\u03b9\u03b1 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ae \u03bd\u03cc\u03c3\u03bf, \u03cc\u03c0\u03c9\u03c2 \u03c4\u03b1 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 C-\u03b1\u03bd\u03c4\u03b9\u03b4\u03c1\u03ce\u03c3\u03b1\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03b7\u03c2 (CRP), \u03c4\u03b7\u03c2 \u03bf\u03bc\u03bf\u03ba\u03c5\u03c3\u03c4\u03b5\u03ca\u03bd\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 Lp(a) \u03b4\u03b5 \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c3\u03c5\u03c3\u03c7\u03ad\u03c4\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03a5\u03a5\u0398 (56,57). \u038c\u03c3\u03bf\u03bd \u03b1\u03c6\u03bf\u03c1\u03ac \u03c3\u03c4\u03b7 \u03c3\u03c5\u03c3\u03c7\u03ad\u03c4\u03b9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03a5\u03a5\u0398 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ae \u03bd\u03cc\u03c3\u03bf (\u039a\u0391\u039d) \u03ad\u03c7\u03b5\u03b9 \u03b5\u03ba\u03c4\u03b9\u03bc\u03b7\u03b8\u03b5\u03af \u03c3\u03b5 \u03b1\u03c1\u03ba\u03b5\u03c4\u03ad\u03c2 \u03b5\u03c0\u03b9\u03b4\u03b7\u03bc\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2. \u03a3\u03c4\u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 Rotterdam \u03bc\u03b5\u03c4\u03b1\u03be\u03cd 1149 \u03b3\u03c5\u03bd\u03b1\u03b9\u03ba\u03ce\u03bd \u03ac\u03bd\u03c9 \u03c4\u03c9\u03bd 55 \u03b5\u03c4\u03ce\u03bd \u03b4\u03b9\u03b1\u03c0\u03b9\u03c3\u03c4\u03ce\u03b8\u03b7\u03ba\u03b5 \u03c3\u03c5\u03c3\u03c7\u03ad\u03c4\u03b9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03a5\u03a5\u0398 \u03ba\u03b1\u03b9 \u03c4\u03bf\u03c5 \u03b5\u03bc\u03c6\u03c1\u03ac\u03b3\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03bc\u03c5\u03bf\u03ba\u03b1\u03c1\u03b4\u03af\u03bf\u03c5 (\u03b4\u03b9\u03c0\u03bb\u03ac\u03c3\u03b9\u03bf\u03c2 \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2) \u03ba\u03b1\u03b8\u03ce\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03b1\u03c0\u03bf\u03c4\u03b9\u03c4\u03ac\u03bd\u03c9\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03b1\u03bf\u03c1\u03c4\u03ae\u03c2 (58). \u03a3\u03b5 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b7 \u03bd\u03bf\u03c1\u03b2\u03b7\u03b3\u03b9\u03ba\u03ae \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 (25000 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03b7\u03bb\u03b9\u03ba\u03af\u03b1\u03c2 60 \u03b5\u03c4\u03ce\u03bd, \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7\u03c2 8,3 \u03ad\u03c4\u03b7), \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03b7\u03c2 TSH \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03bd \u03b8\u03b5\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5 \u03c4\u03b7\u03bd \u03bf\u03bb\u03b9\u03ba\u03ae \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ae \u03b8\u03bd\u03b7\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c3\u03c4\u03b9\u03c2 \u03b3\u03c5\u03bd\u03b1\u03af\u03ba\u03b5\u03c2 \u03b1\u03bb\u03bb\u03ac \u03cc\u03c7\u03b9 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03ac\u03bd\u03b4\u03c1\u03b5\u03c2 (59). \u0397 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 NAHS (Nagasaki Adult Health Study -2856 \u03bc\u03b5\u03c3\u03ae\u03bb\u03b9\u03ba\u03b5\u03c2 \u03ac\u03bd\u03b4\u03c1\u03b5\u03c2 \u03b5\u03c0\u03b9\u03b2\u03b9\u03ce\u03c3\u03b1\u03bd\u03c4\u03b5\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b1\u03c4\u03bf\u03bc\u03b9\u03ba\u03ae \u03b2\u03cc\u03bc\u03b2\u03b1) \u03c9\u03c3\u03c4\u03cc\u03c3\u03bf \u03ad\u03b4\u03b5\u03b9\u03be\u03b5 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u039a\u0391\u039d (60). \u03a3\u03c4\u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 Wickham \u03b4\u03b5 \u03b4\u03b9\u03b1\u03c0\u03b9\u03c3\u03c4\u03ce\u03b8\u03b7\u03ba\u03b5 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03b8\u03bd\u03b7\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b1\u03c0\u03cc \u039a\u0391\u039d \u03ba\u03b1\u03c4\u03ac \u03c4\u03b1 20 \u03ad\u03c4\u03b7 \u03c0\u03b1\u03c1\u03b1\u03c4\u03ae\u03c1\u03b7\u03c3\u03b7\u03c2 (61). \u03a3\u03b5 \u03bc\u03b9\u03b1 \u03c0\u03c1\u03cc\u03c3\u03c6\u03b1\u03c4\u03b7 \u03b5\u03c0\u03b1\u03bd\u03b5\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03af\u03b1 \u03c4\u03c9\u03bd \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03c9\u03bd \u03c4\u03b7\u03c2 \u03af\u03b4\u03b9\u03b1\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7\u03c2 (97 \u03ac\u03c4\u03bf\u03bc\u03b1, \u03bc\u03ad\u03c3\u03b7\u03c2 \u03b7\u03bb\u03b9\u03ba\u03af\u03b1\u03c2 49 \u03ad\u03c4\u03b7) \u03b2\u03c1\u03ad\u03b8\u03b7\u03ba\u03b5 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b7 \u03b1\u03c1\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae \u03c0\u03af\u03b5\u03c3\u03b7 \u03c3\u03c4\u03b9\u03c2 \u03b3\u03c5\u03bd\u03b1\u03af\u03ba\u03b5\u03c2 \u03bc\u03b5 \u03a5\u03a5\u0398 \u03ba\u03b1\u03b8\u03ce\u03c2 \u03ba\u03b1\u03b9 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03bf\u03bb\u03b9\u03ba\u03ae\u03c2, LDL-\u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03bf\u03bc\u03bf\u03ba\u03c5\u03c3\u03c4\u03b5\u03ca\u03bd\u03b7\u03c2 \u03c3\u03b5 \u03c3\u03c7\u03ad\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b9\u03c2 \u03b3\u03c5\u03bd\u03b1\u03af\u03ba\u03b5\u03c2 \u03bc\u03b5 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03c4\u03b9\u03bc\u03ad\u03c2 TSH. \u0394\u03b9\u03b1\u03c0\u03b9\u03c3\u03c4\u03ce\u03b8\u03b7\u03ba\u03b5 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03b8\u03b5\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03c3\u03c7\u03ad\u03c4\u03b9\u03c3\u03b7 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03a5\u03a5\u0398 \u03ba\u03b1\u03b9 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u03b9\u03c3\u03c7\u03b1\u03b9\u03bc\u03b9\u03ba\u03ae\u03c2 \u039a\u0391\u039d (62). \u03a3\u03c4\u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 Busseltron \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u0391\u03c5\u03c3\u03c4\u03c1\u03b1\u03bb\u03af\u03b1 (3447 \u03ac\u03c4\u03bf\u03bc\u03b1, \u03bc\u03ad\u03c3\u03b7\u03c2 \u03b7\u03bb\u03b9\u03ba\u03af\u03b1\u03c2 49,8 \u03ad\u03c4\u03b7) \u03b2\u03c1\u03ad\u03b8\u03b7\u03ba\u03b5 \u03c3\u03c5\u03c3\u03c7\u03ad\u03c4\u03b9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b5\u03c0\u03b9\u03c0\u03ad\u03b4\u03c9\u03bd \u03c4\u03b7\u03c2 TSH \u03bc\u03b5 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u039a\u0391\u039d \u03c4\u03cc\u03c3\u03bf \u03c3\u03c4\u03b7\u03bd \u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 \u03c7\u03c1\u03bf\u03bd\u03b9\u03ba\u03ae\u03c2 \u03c3\u03c4\u03b9\u03b3\u03bc\u03ae\u03c2 \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03c0\u03c1\u03bf\u03bf\u03c0\u03c4\u03b9\u03ba\u03ae \u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 (20 \u03ad\u03c4\u03b7) \u03c4\u03c9\u03bd \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03c9\u03bd (63). \u0386\u03bb\u03bb\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c9\u03c3\u03c4\u03cc\u03c3\u03bf \u03b4\u03b5\u03bd \u03ad\u03b4\u03b5\u03b9\u03be\u03b1\u03bd \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03cc \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u039a\u0391\u039d (61,64-66). \u0397 \u03b4\u03b9\u03b1\u03ba\u03cd\u03bc\u03b1\u03bd\u03c3\u03b7 \u03b1\u03c5\u03c4\u03ae \u03c4\u03c9\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03ac\u03c4\u03c9\u03bd \u03c4\u03c9\u03bd \u03c0\u03c1\u03bf\u03b1\u03bd\u03b1\u03c6\u03b5\u03c1\u03b8\u03b5\u03b9\u03c3\u03ce\u03bd \u03bc\u03b5\u03bb\u03b5\u03c4\u03ce\u03bd \u03b1\u03bd\u03b1\u03c6\u03bf\u03c1\u03b9\u03ba\u03ac \u03bc\u03b5 \u03c4\u03bf\u03bd \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u039a\u0391\u039d \u03c0\u03c1\u03bf\u03c6\u03b1\u03bd\u03ce\u03c2 \u03ad\u03b3\u03ba\u03b5\u03b9\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03c0\u03c1\u03bf\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03bf\u03cd\u03c2 (\u03b1\u03c1\u03b9\u03b8\u03bc\u03cc\u03c2, \u03b7\u03bb\u03b9\u03ba\u03af\u03b1, \u03c6\u03cd\u03bb\u03bf, \u03c6\u03c5\u03bb\u03ae\/\u03b5\u03b8\u03bd\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1, \u03c4\u03c1\u03cc\u03c0\u03bf\u03c2 \u03b6\u03c9\u03ae\u03c2) \u03ba\u03b1\u03b8\u03ce\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b1 \u03cc\u03c1\u03b9\u03b1 \u03bf\u03c1\u03b9\u03c3\u03bc\u03bf\u03cd \u03c4\u03bf\u03c5 \u03a5\u03a5\u0398, \u03c3\u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03b7\u03c2 TSH, \u03c3\u03c4\u03b7 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u039a\u0391\u039d, \u03c3\u03c4\u03b7 \u03bc\u03b7 \u03bf\u03bc\u03bf\u03b9\u03bf\u03b3\u03b5\u03bd\u03ae \u03c3\u03c5\u03bd\u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03b3\u03bd\u03c9\u03c3\u03c4\u03ce\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03cc\u03bd\u03c4\u03c9\u03bd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03c0\u03b1\u03c1\u03b1\u03c4\u03ae\u03c1\u03b7\u03c3\u03b7\u03c2. \u0395\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd \u03b1\u03c1\u03ba\u03b5\u03c4\u03ad\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03b4\u03b5 \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03b5\u03bb\u03ac\u03bc\u03b2\u03b1\u03bd\u03b1\u03bd \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03c4\u03c1\u03bf\u03c5\u03c2 \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7\u03c2 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2 \u03ba\u03b1\u03c4\u03ac \u03c4\u03bf\u03bd \u03b5\u03c0\u03b1\u03bd\u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03ae \u03c4\u03b7 \u03bb\u03ae\u03c8\u03b7 LT4. \u0394\u03cd\u03bf \u03bc\u03b5\u03c4\u03b1-\u03b1\u03bd\u03b1\u03bb\u03cd\u03c3\u03b5\u03b9\u03c2 \u03b5\u03c0\u03b9\u03c7\u03b5\u03af\u03c1\u03b7\u03c3\u03b1\u03bd \u03bd\u03b1 \u03b5\u03c0\u03b1\u03bd\u03b1\u03be\u03b9\u03bf\u03bb\u03bf\u03b3\u03ae\u03c3\u03bf\u03c5\u03bd \u03c4\u03b1 \u03b1\u03bd\u03c9\u03c4\u03ad\u03c1\u03c9 \u03bc\u03b5\u03b8\u03bf\u03b4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03c0\u03c1\u03bf\u03b2\u03bb\u03ae\u03bc\u03b1\u03c4\u03b1. \u03a4\u03bf \u03ba\u03cd\u03c1\u03b9\u03bf \u03b5\u03cd\u03c1\u03b7\u03bc\u03b1 \u03c4\u03b7\u03c2 \u03c0\u03c1\u03ce\u03c4\u03b7\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2 \u039a\u0391\u039d \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf\u03c2 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03a5\u03a5\u0398 \u03ba\u03ac\u03c4\u03c9 \u03c4\u03c9\u03bd 65 \u03b5\u03c4\u03ce\u03bd \u03b1\u03bb\u03bb\u03ac \u03cc\u03c7\u03b9 \u03c3\u03b5 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7\u03c2 \u03b7\u03bb\u03b9\u03ba\u03af\u03b1\u03c2 \u03ac\u03c4\u03bf\u03bc\u03b1 (67). \u0397 \u03b4\u03b5\u03cd\u03c4\u03b5\u03c1\u03b7 \u03ad\u03b4\u03b5\u03b9\u03be\u03b5 \u03cc\u03c4\u03b9 \u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2 \u039a\u0391\u039d \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03b7 \u03b2\u03b1\u03c1\u03cd\u03c4\u03b7\u03c4\u03b1 \u03c4\u03bf\u03c5 \u03a5\u03a5\u0398 \u03ba\u03b1\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c5\u03c8\u03b7\u03bb\u03cc\u03c2 \u03c3\u03b5 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03bc\u03b5 TSH>10,0 mU\/L (68). \u03a4\u03b1 \u03b5\u03c5\u03c1\u03ae\u03bc\u03b1\u03c4\u03b1 \u03b1\u03c5\u03c4\u03ac \u03b4\u03b5\u03bd \u03b9\u03c3\u03c7\u03cd\u03bf\u03c5\u03bd \u03ba\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03b1 \u03b4\u03cd\u03bf \u03c6\u03cd\u03bb\u03b1 \u03b1\u03bb\u03bb\u03ac \u03ad\u03c7\u03bf\u03c5\u03bd \u03c3\u03c4\u03b1\u03c4\u03b9\u03c3\u03c4\u03b9\u03ba\u03ae \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03bc\u03cc\u03bd\u03bf \u03c3\u03c4\u03b9\u03c2 \u03b3\u03c5\u03bd\u03b1\u03af\u03ba\u03b5\u03c2 (67). \u0386\u03bb\u03bb\u03b7 \u03bc\u03b5\u03c4\u03b1-\u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 11 \u03c0\u03c1\u03bf\u03bf\u03c0\u03c4\u03b9\u03ba\u03ce\u03bd \u03bc\u03b5\u03bb\u03b5\u03c4\u03ce\u03bd \u03bc\u03b5 55287 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ac \u03ac\u03c4\u03bf\u03bc\u03b1 \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03cc\u03c3\u03bf \u03c4\u03bf\u03bd \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u039a\u0391\u039d \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b8\u03bd\u03b7\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b1\u03c0\u03cc \u039a\u0391\u039d \u03b1\u03bb\u03bb\u03ac \u03bc\u03cc\u03bd\u03bf \u03c3\u03c4\u03b1 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03bc\u03b5 TSH>10,0 mU\/L, \u03c7\u03c9\u03c1\u03af\u03c2 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03ac \u03b1\u03bd\u03ac\u03bc\u03b5\u03c3\u03b1 \u03c3\u03c4\u03b1 \u03b4\u03cd\u03bf \u03c6\u03cd\u03bb\u03b1 (69). \u03a4\u03ad\u03bb\u03bf\u03c2, \u03c3\u03c4\u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 PROSPER (Prospective Study of Pravastatin in the Elderly at Risk- \u03b7\u03bb\u03b9\u03ba\u03af\u03b1 70-82 \u03ad\u03c4\u03b7, \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc \u039a\u0391\u039d) \u03b4\u03b9\u03b1\u03c0\u03b9\u03c3\u03c4\u03ce\u03b8\u03b7\u03ba\u03b5 \u03cc\u03c4\u03b9 \u03bf \u03a5\u03a5\u0398 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03ba\u03ae\u03c2 \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1\u03c2 \u03bc\u03cc\u03bd\u03bf \u03cc\u03bc\u03c9\u03c2 \u03c3\u03c4\u03b1 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03bc\u03b5 TSH > 10 mU\/L (HR 3,01, 95% CI 1,12 – 8,11, p=0,029) (70).<\/p>\n \u03a3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b1\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03cc\u03c0\u03c9\u03c2 \u03ba\u03b1\u03c4\u03b1\u03b4\u03b5\u03b9\u03ba\u03bd\u03cd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1 \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03b1\u03bd\u03b1\u03c6\u03ad\u03c1\u03b8\u03b7\u03ba\u03b1\u03bd, \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03c4\u03b1 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03bc\u03b5 \u03a5\u03a5\u0398 \u03ba\u03b1\u03b9 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03b1\u03c5\u03c4\u03ac \u03bc\u03b5 \u03c4\u03b9\u03bc\u03ad\u03c2 TSH>10,0 mU\/L \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03bf\u03c5\u03bd \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u039a\u0391\u039d. \u039f \u03c1\u03cc\u03bb\u03bf\u03c2 \u03c4\u03b7\u03c2 \u03b7\u03bb\u03b9\u03ba\u03af\u03b1\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03bc\u03c6\u03b9\u03bb\u03b5\u03b3\u03cc\u03bc\u03b5\u03bd\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03bc\u03ac\u03bb\u03bb\u03bf\u03bd \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b5\u03af \u03b5\u03c5\u03bd\u03bf\u03ca\u03ba\u03ac \u03c3\u03c4\u03b1 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b7\u03c2 \u03b7\u03bb\u03b9\u03ba\u03af\u03b1\u03c2 \u03ac\u03c4\u03bf\u03bc\u03b1. \u0391\u03bc\u03c6\u03b9\u03bb\u03b5\u03b3\u03cc\u03bc\u03b5\u03bd\u03bf\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03bf \u03c1\u03cc\u03bb\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03c6\u03cd\u03bb\u03bf\u03c5.<\/p>\n 5.4. \u0395\u03c0\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03a5\u03a5\u0398 \u03c3\u03b5 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ae \u03ba\u03b1\u03b9 \u03bf\u03bb\u03b9\u03ba\u03ae \u03b8\u03bd\u03b7\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1<\/b><\/h5>\n\u03a4\u03b1 \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1 \u03b1\u03bd\u03b1\u03c6\u03bf\u03c1\u03b9\u03ba\u03ac \u03bc\u03b5 \u03c4\u03bf\u03bd \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ae\u03c2 \u03ba\u03b1\u03b9 \u03bf\u03bb\u03b9\u03ba\u03ae\u03c2 \u03b8\u03bd\u03b7\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c3\u03b5 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03bc\u03b5 \u03a5\u03a5\u0398 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03bf\u03b9\u03ba\u03af\u03bb\u03b1 \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03bc\u03b5\u03b3\u03ac\u03bb\u03bf \u03b2\u03b1\u03b8\u03bc\u03cc \u03b1\u03bd\u03c4\u03b9\u03ba\u03c1\u03bf\u03c5\u03cc\u03bc\u03b5\u03bd\u03b1 (59-61, 63-66, 71-74). \u03a5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd 3 \u03bc\u03b5\u03c4\u03b1-\u03b1\u03bd\u03b1\u03bb\u03cd\u03c3\u03b5\u03b9\u03c2 \u03c3\u03c4\u03b9\u03c2 \u03bf\u03c0\u03bf\u03af\u03b5\u03c2 \u03b5\u03ba\u03c4\u03b9\u03bc\u03ae\u03b8\u03b7\u03ba\u03b5 \u03c4\u03cc\u03c3\u03bf \u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2 \u03c4\u03b7\u03c2 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ae\u03c2 \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03bf\u03bb\u03b9\u03ba\u03ae\u03c2 \u03b8\u03bd\u03b7\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c3\u03b5 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03bc\u03b5 \u03a5\u03a5\u0398, \u03c0\u03bf\u03c5 \u03b4\u03b7\u03bc\u03bf\u03c3\u03b9\u03b5\u03cd\u03b8\u03b7\u03ba\u03b1\u03bd \u03bc\u03b5\u03c4\u03b1\u03be\u03cd 2008 – 2010 (67-69).<\/p>\n \u03a3\u03c4\u03b7\u03bd \u03c0\u03c1\u03ce\u03c4\u03b7 \u03bc\u03b5\u03c4\u03b1-\u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 \u03b4\u03b9\u03b1\u03c0\u03b9\u03c3\u03c4\u03ce\u03b8\u03b7\u03ba\u03b5 \u03cc\u03c4\u03b9 \u03b7 \u03b8\u03bd\u03b7\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b1\u03c0\u03cc \u039a\u0391\u039d \u03ae\u03c4\u03b1\u03bd \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03c3\u03b5 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03bc\u03b5 \u03a5\u03a5\u0398 \u03bd\u03b5\u03cc\u03c4\u03b5\u03c1\u03b1 \u03c4\u03c9\u03bd 65 \u03b5\u03c4\u03ce\u03bd, \u03cc\u03c7\u03b9 \u03cc\u03bc\u03c9\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7\u03c2 \u03b7\u03bb\u03b9\u03ba\u03af\u03b1\u03c2 (67). \u03a3\u03c4\u03b7 \u03bc\u03b5\u03c4\u03b1-\u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 \u03c4\u03c9\u03bd Ochs \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bd. \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03b9\u03ce\u03b8\u03b7\u03ba\u03b1\u03bd \u03bf \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf\u03c2 \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2 \u03c4\u03cc\u03c3\u03bf \u03b1\u03c0\u03cc \u039a\u0391\u039d \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03bf\u03bb\u03b9\u03ba\u03ae\u03c2 \u03b8\u03bd\u03b7\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2, \u03c3\u03c4\u03b1 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03bc\u03b5 \u03a5\u03a5\u0398 \u03b7\u03bb\u03b9\u03ba\u03af\u03b1\u03c2 \u03ba\u03ac\u03c4\u03c9 \u03c4\u03c9\u03bd 65 \u03b5\u03c4\u03ce\u03bd (68). \u03a3\u03c4\u03b7\u03bd \u03c4\u03b5\u03bb\u03b5\u03c5\u03c4\u03b1\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c0\u03b9\u03bf \u03c0\u03c1\u03cc\u03c3\u03c6\u03b1\u03c4\u03b7 \u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 \u03bf \u03a5\u03a5\u0398 \u03b2\u03c1\u03ad\u03b8\u03b7\u03ba\u03b5 \u03bd\u03b1 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u039a\u0391\u039d \u03ba\u03b1\u03b9 \u03b8\u03bd\u03b7\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b1\u03c0\u03cc \u039a\u0391\u039d \u03c3\u03c4\u03b1 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03bc\u03b5 \u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03c4\u03b9\u03bc\u03ad\u03c2 TSH \u03ba\u03b1\u03b9 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03bc\u03b5 \u03c4\u03b9\u03bc\u03ad\u03c2 TSH > 10 mU\/L. \u03a3\u03c4\u03b7\u03bd \u03af\u03b4\u03b9\u03b1 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03b4\u03b5 \u03b4\u03b9\u03b1\u03c0\u03b9\u03c3\u03c4\u03ce\u03b8\u03b7\u03ba\u03b5 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf\u03c2 \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2 \u039a\u0391\u039d \u03ba\u03b1\u03b9 \u03bf\u03bb\u03b9\u03ba\u03ae\u03c2 \u03b8\u03bd\u03b7\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c3\u03c4\u03b7\u03bd \u03c5\u03c0\u03bf-\u03bf\u03bc\u03ac\u03b4\u03b1 \u03c4\u03c9\u03bd \u03b1\u03c4\u03cc\u03bc\u03c9\u03bd > 80 \u03b5\u03c4\u03ce\u03bd (69). \u03a0\u03b1\u03c1\u03cc\u03bc\u03bf\u03b9\u03b1 \u03b5\u03c5\u03c1\u03ae\u03bc\u03b1\u03c4\u03b1 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5 \u03c4\u03b7\u03bd \u03bf\u03bb\u03b9\u03ba\u03ae \u03b8\u03bd\u03b7\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c3\u03b5 \u03b7\u03bb\u03b9\u03ba\u03b9\u03c9\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2 \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03bf\u03cd\u03c2 \u03ad\u03b4\u03b5\u03b9\u03be\u03b5 \u03ba\u03b1\u03b9 \u03bd\u03b5\u03cc\u03c4\u03b5\u03c1\u03b7 \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03b9\u03b1\u03ba\u03ae \u03c0\u03c1\u03bf\u03bf\u03c0\u03c4\u03b9\u03ba\u03ae \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 (74). \u03a4\u03b1 \u03c9\u03c2 \u03ac\u03bd\u03c9 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03bd\u03b4\u03b5\u03b9\u03ba\u03c4\u03b9\u03ba\u03ac \u03c4\u03bf\u03c5 \u03cc\u03c4\u03b9 \u03bf\u03b9 \u2018\u03c0\u03b1\u03c1\u03b1\u03b4\u03bf\u03c3\u03b9\u03b1\u03ba\u03bf\u03af\u2019 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03bf\u03af \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u03c3\u03b5 \u03bd\u03b5\u03cc\u03c4\u03b5\u03c1\u03b7\u03c2 \u03b7\u03bb\u03b9\u03ba\u03af\u03b1\u03c2 \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03bf\u03cd\u03c2 \u03cc\u03c0\u03c9\u03c2 \u03c0.\u03c7 \u03b7 \u03c5\u03c0\u03b5\u03c1\u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03bf\u03bb\u03b1\u03b9\u03bc\u03af\u03b1, \u03b7 \u03b4\u03b9\u03b1\u03c3\u03c4\u03bf\u03bb\u03b9\u03ba\u03ae \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7, \u03b7 \u03b5\u03bd\u03b4\u03bf\u03b8\u03b7\u03bb\u03b9\u03b1\u03ba\u03ae \u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1, \u03b7 \u03c0\u03b1\u03c7\u03c5\u03c3\u03b1\u03c1\u03ba\u03af\u03b1 \u03ba\u03b1\u03b9 \u03b7 \u03b9\u03bd\u03c3\u03bf\u03c5\u03bb\u03b9\u03bd\u03bf\u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03b1\u03c3\u03b7 \u03af\u03c3\u03c9\u03c2 \u03bd\u03b1 \u03b5\u03bd\u03ad\u03c7\u03bf\u03c5\u03bd \u03bc\u03b9\u03ba\u03c1\u03cc\u03c4\u03b5\u03c1\u03bf \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03cc \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03c3\u03c4\u03b1 \u03b7\u03bb\u03b9\u03ba\u03b9\u03c9\u03bc\u03ad\u03bd\u03b1 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03ae \u03b5\u03bd\u03b4\u03b5\u03c7\u03bf\u03bc\u03ad\u03bd\u03c9\u03c2 \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03b7\u03c2 TSH \u03c3\u03c4\u03b1 \u03cc\u03c1\u03b9\u03b1 \u03c4\u03bf\u03c5 \u03a5\u03a5\u0398 \u03bd\u03b1 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03bf\u03cd\u03bd \u03c0\u03c1\u03bf\u03c3\u03c4\u03b1\u03c4\u03b5\u03c5\u03c4\u03b9\u03ba\u03ac \u03c3\u03b5 \u03b1\u03c5\u03c4\u03ac \u03c4\u03b1 \u03ac\u03c4\u03bf\u03bc\u03b1 (2). \u03a3\u03b5 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ae \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03c3\u03b5 \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03cc \u03b7\u03bb\u03b9\u03ba\u03b9\u03c9\u03bc\u03ad\u03bd\u03c9\u03bd \u03b1\u03bd\u03b4\u03c1\u03ce\u03bd \u03c0\u03bf\u03c5 \u03b6\u03bf\u03cd\u03c3\u03b1\u03bd \u03bc\u03cc\u03bd\u03bf\u03b9 \u03c4\u03bf\u03c5\u03c2, \u03c4\u03b1 \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 FT4 \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b1 \u03c4\u03b7\u03c2 TSH, \u03c3\u03c4\u03b1 \u03cc\u03c1\u03b9\u03b1 \u03c4\u03bf\u03c5 \u03a5\u03a5\u0398, \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03bd \u03bc\u03b5 \u03ba\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03c4\u03b5\u03c4\u03c1\u03b1\u03b5\u03c4\u03ae \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 (75). \u03a0\u03c1\u03bf\u03c2 \u03c4\u03b7\u03bd \u03ba\u03b1\u03c4\u03b5\u03cd\u03b8\u03c5\u03bd\u03c3\u03b7 \u03b1\u03c5\u03c4\u03ae \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03bf\u03cd\u03bd \u03c5\u03c0\u03bf\u03c3\u03c4\u03b7\u03c1\u03b9\u03ba\u03c4\u03b9\u03ba\u03ac \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03ac\u03bb\u03bb\u03b7\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7\u03c2 \u03c3\u03c4\u03b7\u03bd \u03bf\u03c0\u03bf\u03af\u03b1 \u03b4\u03b9\u03b1\u03c0\u03b9\u03c3\u03c4\u03ce\u03b8\u03b7\u03ba\u03b5 \u03cc\u03c4\u03b9 \u03b7 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03c0\u03c1\u03bf\u03b4\u03b9\u03ac\u03b8\u03b5\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 TSH (\u03c6\u03bf\u03c1\u03b5\u03af\u03c2 \u03c4\u03c9\u03bd SNPs rs12050077 \u03ba\u03b1\u03b9 rs10149689 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03c4\u03b7\u03c2 TSH) \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03b1\u03c3\u03c5\u03bd\u03ae\u03b8\u03b9\u03c3\u03c4\u03b7 \u03bc\u03b1\u03ba\u03c1\u03bf\u03b6\u03c9\u03af\u03b1 \u03b5\u03bd\u03b4\u03b5\u03c7\u03bf\u03bc\u03ad\u03bd\u03c9\u03c2 \u03bb\u03cc\u03b3\u03c9 \u03bc\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7\u03c2 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2 (76).<\/p>\n \u03a3\u03c4\u03b1 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03bc\u03b5 \u03b3\u03bd\u03c9\u03c3\u03c4\u03ae \u039a\u0391\u039d, \u03bf \u03a5\u03a5\u0398 \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ae \u03b8\u03bd\u03b7\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1 (73). \u03a3\u03b5 \u03bc\u03b5\u03c4\u03b1-\u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 \u03b2\u03c1\u03ad\u03b8\u03b7\u03ba\u03b5 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf\u03c2 \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2 \u03bf\u03bb\u03b9\u03ba\u03ae\u03c2 \u03b8\u03bd\u03b7\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c3\u03b5 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03bc\u03b5 \u03a5\u03a5\u0398 \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bd\u03bf\u03c3\u03b7\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c3\u03c5\u03b3\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5 \u03b5\u03c5\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03bc\u03ac\u03c1\u03c4\u03c5\u03c1\u03b5\u03c2 (77).<\/p>\n \u03a9\u03c2 \u03c3\u03c5\u03bc\u03c0\u03ad\u03c1\u03b1\u03c3\u03bc\u03b1 \u03b8\u03b1 \u03bb\u03ad\u03b3\u03b1\u03bc\u03b5 \u03cc\u03c4\u03b9 \u03bf \u03a5\u03a5\u0398 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ae \u03bd\u03bf\u03c3\u03b7\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03b8\u03bd\u03b7\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b1\u03c0\u03cc \u039a\u0391\u039d \u03c3\u03b5 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03b7\u03bb\u03b9\u03ba\u03af\u03b1\u03c2 \u03ba\u03ac\u03c4\u03c9 \u03c4\u03c9\u03bd 65 \u03b5\u03c4\u03ce\u03bd \u03bc\u03b5 \u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 TSH, \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03cc\u03c4\u03b1\u03bd \u03b1\u03c5\u03c4\u03ac \u03c5\u03c0\u03b5\u03c1\u03b2\u03b1\u03af\u03bd\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03c4\u03b9\u03bc\u03ae \u03c4\u03c9\u03bd 10,0 mU\/L.<\/p>\n 5.5. \u0395\u03c0\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03a5\u03a5\u0398 \u03c3\u03b5 \u03bd\u03b5\u03c5\u03c1\u03bf\u03bc\u03c5\u03b9\u03ba\u03ae, \u03c8\u03c5\u03c7\u03b9\u03ba\u03ae \u03ba\u03b1\u03b9 \u03bd\u03bf\u03b7\u03c4\u03b9\u03ba\u03ae \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1<\/b><\/h5>\n\u039f \u03a5\u03a5\u0398 \u03ad\u03c7\u03b5\u03b9 \u03c3\u03c5\u03c3\u03c7\u03b5\u03c4\u03b9\u03c3\u03b8\u03b5\u03af \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03b4\u03b5\u03af\u03bd\u03c9\u03c3\u03b7 \u03b5\u03bd\u03cc\u03c2 \u03bc\u03b5\u03b3\u03ac\u03bb\u03bf\u03c5 \u03c6\u03ac\u03c3\u03bc\u03b1\u03c4\u03bf\u03c2 \u03bd\u03b5\u03c5\u03c1\u03bf\u03bc\u03c5\u03b9\u03ba\u03ae\u03c2 \u03ba\u03b1\u03b9 \u03bc\u03c5\u03b9\u03ba\u03ae\u03c2 \u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2 \u03b7 \u03c0\u03b1\u03b8\u03bf\u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03b2\u03ac\u03c3\u03b7 \u03c4\u03c9\u03bd \u03bf\u03c0\u03bf\u03af\u03c9\u03bd \u03b4\u03b5\u03bd \u03ad\u03c7\u03b5\u03b9 \u03ba\u03b1\u03c4\u03b1\u03bd\u03bf\u03b7\u03b8\u03b5\u03af \u03c0\u03bb\u03ae\u03c1\u03c9\u03c2 (1). \u039c\u03b5\u03c4\u03b1\u03be\u03cd \u03c4\u03c9\u03bd \u03c0\u03b1\u03b8\u03bf\u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ce\u03bd \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03ce\u03bd \u03c0\u03bf\u03c5 \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03bd \u03b5\u03bc\u03c0\u03bb\u03ad\u03ba\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b7 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ae \u03c4\u03b7\u03c2 \u03b3\u03bb\u03c5\u03ba\u03bf\u03b3\u03bf\u03bd\u03cc\u03bb\u03c5\u03c3\u03b7\u03c2 (78,79), \u03c4\u03b7\u03c2 \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae\u03c2 \u03bc\u03c5\u03bf\u03c3\u03af\u03bd\u03b7\u03c2 (80), \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2 \u03c4\u03c9\u03bd \u03bc\u03b9\u03c4\u03bf\u03c7\u03bf\u03bd\u03b4\u03c1\u03af\u03c9\u03bd (81,82). \u03a4\u03bf \u03b5\u03cd\u03c1\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03b1\u03c7\u03af\u03bb\u03bb\u03b5\u03b9\u03bf\u03c5 \u03b1\u03bd\u03c4\u03b1\u03bd\u03b1\u03ba\u03bb\u03b1\u03c3\u03c4\u03b9\u03ba\u03bf\u03cd, \u03c4\u03bf \u03bf\u03c0\u03bf\u03af\u03bf \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03bc\u03b9\u03b1 \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03c0\u03b1\u03c1\u03ac\u03bc\u03b5\u03c4\u03c1\u03bf \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03bd\u03b5\u03c5\u03c1\u03bf\u03bc\u03c5\u03b9\u03ba\u03ae\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2, \u03ad\u03c7\u03b5\u03b9 \u03b2\u03c1\u03b5\u03b8\u03b5\u03af \u03c0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c4\u03cc\u03c3\u03bf \u03bc\u03b5 \u03ad\u03ba\u03b4\u03b7\u03bb\u03bf \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03bc\u03b5 \u03a5\u03a5\u0398 (83). \u0391\u03bd\u03c4\u03af\u03b8\u03b5\u03c4\u03b1, \u03b4\u03b5\u03bd \u03ad\u03c7\u03bf\u03c5\u03bd \u03b4\u03b9\u03b1\u03c0\u03b9\u03c3\u03c4\u03c9\u03b8\u03b5\u03af \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ad\u03c2 \u03c4\u03b7\u03c2 \u03b1\u03b3\u03c9\u03b3\u03b9\u03bc\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c3\u03c4\u03bf \u03b5\u03cd\u03c1\u03bf\u03c2 \u03c4\u03b7\u03c2 \u03ba\u03b9\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae\u03c2- \u03b1\u03b9\u03c3\u03b8\u03b7\u03c4\u03b9\u03ba\u03ae\u03c2 \u03bd\u03b5\u03c5\u03c1\u03b9\u03ba\u03ae\u03c2 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2, \u03ba\u03b1\u03b8\u03ce\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03c4\u03b1\u03c7\u03cd\u03c4\u03b7\u03c4\u03b1 \u03b1\u03b3\u03c9\u03b3\u03ae\u03c2 \u03c4\u03bf\u03c5 \u03b5\u03c1\u03b5\u03b8\u03af\u03c3\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c4\u03c9\u03bd \u03c0\u03b5\u03c1\u03b9\u03c6\u03b5\u03c1\u03b9\u03ba\u03ce\u03bd \u03bd\u03b5\u03cd\u03c1\u03c9\u03bd \u03c4\u03c9\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03bc\u03b5 \u03a5\u03a5\u0398 (84). \u0391\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03b5\u03c5\u03c1\u03ae\u03bc\u03b1\u03c4\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03c0\u03b5\u03c1\u03b9\u03c6\u03b5\u03c1\u03b9\u03ba\u03ac \u03bd\u03b5\u03cd\u03c1\u03b1 \u03ba\u03b1\u03b8\u03ce\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c5\u03c3\u03af\u03b1 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ce\u03bd \u03c3\u03c4\u03b1 \u03c0\u03c1\u03bf\u03ba\u03bb\u03b7\u03c4\u03ac \u03b4\u03c5\u03bd\u03b1\u03bc\u03b9\u03ba\u03ac \u03c4\u03bf\u03c5 \u03b1\u03ba\u03bf\u03c5\u03c3\u03c4\u03b9\u03ba\u03bf\u03cd \u03bd\u03b5\u03cd\u03c1\u03bf\u03c5 \u03b4\u03b9\u03b1\u03c0\u03b9\u03c3\u03c4\u03ce\u03b8\u03b7\u03ba\u03b1\u03bd \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03a5\u03a5\u0398 \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03ac\u03bb\u03bb\u03b7 \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 (85).<\/p>\n \u0391\u03bd\u03c4\u03af\u03b8\u03b5\u03c4\u03b1, \u03cc\u03c3\u03bf\u03bd \u03b1\u03c6\u03bf\u03c1\u03ac \u03c3\u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03b7\u03c2 \u03ba\u03c1\u03b5\u03b1\u03c4\u03b9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03c6\u03c9\u03c3\u03c6\u03bf\u03ba\u03b9\u03bd\u03ac\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03bc\u03c5\u03bf\u03c3\u03c6\u03b1\u03b9\u03c1\u03af\u03bd\u03b7\u03c2, \u03c4\u03b1 \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03bb\u03bb\u03b7\u03bb\u03bf\u03b1\u03bd\u03b1\u03b9\u03c1\u03bf\u03cd\u03bc\u03b5\u03bd\u03b1 (84, 86-88) , \u03c0\u03b1\u03c1\u03cc\u03c4\u03b9 \u03ad\u03c7\u03b5\u03b9 \u03b4\u03b9\u03b1\u03c0\u03b9\u03c3\u03c4\u03c9\u03b8\u03b5\u03af \u03b8\u03b5\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03c3\u03c7\u03ad\u03c4\u03b9\u03c3\u03b7 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03c4\u03c9\u03bd \u03b5\u03c0\u03b9\u03c0\u03ad\u03b4\u03c9\u03bd \u03c4\u03b7\u03c2 \u03c0\u03c1\u03ce\u03c4\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03b5\u03ba\u03b5\u03af\u03bd\u03c9\u03bd \u03c4\u03b7\u03c2 TSH \u03c4\u03cc\u03c3\u03bf \u03c3\u03c4\u03bf\u03bd \u03ad\u03ba\u03b4\u03b7\u03bb\u03bf \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03c3\u03c4\u03bf\u03bd \u03a5\u03a5\u0398 (84).<\/p>\n \u03a3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03a5\u03a5\u0398 \u03ba\u03b1\u03b9 \u03bd\u03b5\u03c5\u03c1\u03bf\u03bc\u03c5\u03b9\u03ba\u03ac \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1 \u03c0\u03c1\u03bf\u03c3\u03b4\u03b9\u03bf\u03c1\u03af\u03c3\u03c4\u03b7\u03ba\u03b1\u03bd \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03b7 \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03b3\u03b1\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03bf\u03cd \u03ba\u03b1\u03b9 \u03c0\u03c5\u03c1\u03bf\u03c5\u03b2\u03b9\u03ba\u03bf\u03cd \u03bf\u03be\u03ad\u03bf\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5\u03c2 \u03bc\u03cd\u03b5\u03c2 \u03c4\u03cc\u03c3\u03bf \u03c3\u03b5 \u03b7\u03c1\u03b5\u03bc\u03af\u03b1 \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u03ac\u03c3\u03ba\u03b7\u03c3\u03b7, \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03b4\u03b5 \u03b4\u03b9\u03ad\u03c6\u03b5\u03c1\u03b5 \u03b1\u03c0\u03cc \u03b1\u03c5\u03c4\u03ae \u03c4\u03c9\u03bd \u03bc\u03b1\u03c1\u03c4\u03cd\u03c1\u03c9\u03bd. \u03a9\u03c3\u03c4\u03cc\u03c3\u03bf \u03c4\u03b1 \u03bc\u03ad\u03c3\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03b3\u03b1\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03bf\u03cd \u03ba\u03b1\u03b8\u03ce\u03c2 \u03ba\u03b1\u03b9 \u03b7 \u03bc\u03ad\u03c3\u03b7 \u03b1\u03cd\u03be\u03b7\u03c3\u03ae \u03c4\u03bf\u03c5\u03c2 \u03ae\u03c4\u03b1\u03bd \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03a5\u03a5\u0398 \u03c3\u03c4\u03b7 \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 \u03ac\u03c3\u03ba\u03b7\u03c3\u03b7\u03c2 \u03ba\u03ac\u03c4\u03b9 \u03c0\u03bf\u03c5 \u03c5\u03c0\u03bf\u03b4\u03b7\u03bb\u03ce\u03bd\u03b5\u03b9 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ad\u03c2 \u03c3\u03c4\u03b7\u03bd \u03bf\u03be\u03b5\u03b9\u03b4\u03c9\u03c4\u03b9\u03ba\u03ae \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03c4\u03c9\u03bd \u03bc\u03b9\u03c4\u03bf\u03c7\u03bf\u03bd\u03b4\u03c1\u03af\u03c9\u03bd (89). \u03a3\u03b5 \u03ac\u03bb\u03bb\u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03c4\u03b7\u03c2 \u03af\u03b4\u03b9\u03b1\u03c2 \u03bf\u03bc\u03ac\u03b4\u03b1\u03c2 \u03b4\u03b9\u03b1\u03c0\u03b9\u03c3\u03c4\u03ce\u03b8\u03b7\u03ba\u03b5 \u03b5\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03b3\u03bc\u03ad\u03bd\u03bf\u03c2 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03c3\u03bc\u03cc\u03c2 \u03c4\u03c9\u03bd \u03bc\u03c5\u03ce\u03bd \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03b1\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03ae\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03c3\u03b5 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03bf \u03c6\u03bf\u03c1\u03c4\u03af\u03bf \u03ac\u03c3\u03ba\u03b7\u03c3\u03b7\u03c2 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03a5\u03a5\u0398 (90).<\/p>\n \u03a3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b1\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03c4\u03b1 \u03c9\u03c2 \u03ac\u03bd\u03c9 \u03b5\u03c5\u03c1\u03ae\u03bc\u03b1\u03c4\u03b1 \u03c5\u03c0\u03bf\u03c3\u03c4\u03b7\u03c1\u03af\u03b6\u03bf\u03c5\u03bd \u03cc\u03c4\u03b9 \u03b7 \u03bd\u03b5\u03c5\u03c1\u03bf\u03bc\u03c5\u03b9\u03ba\u03ae \u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03ae \u03c3\u03c4\u03bf\u03bd \u03a5\u03a5\u0398 \u03ba\u03b1\u03b9 \u03b5\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd \u03c4\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03c4\u03c9\u03bd \u03bc\u03b5\u03bb\u03b5\u03c4\u03ce\u03bd \u03c0\u03b1\u03c1\u03ad\u03bc\u03b2\u03b1\u03c3\u03b7\u03c2 \u03c5\u03c0\u03bf\u03b4\u03b5\u03b9\u03ba\u03bd\u03cd\u03bf\u03c5\u03bd \u03cc\u03c4\u03b9 \u03bf\u03b9 \u03b5\u03ba\u03b4\u03b7\u03bb\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c4\u03b7\u03c2 \u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2 \u03b1\u03c5\u03c4\u03ae\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03c1\u03ad\u03c8\u03b9\u03bc\u03b5\u03c2 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 LT4 (91). \u0391\u03c5\u03c4\u03cc \u03c0\u03bf\u03c5 \u03b4\u03b5\u03bd \u03c0\u03c1\u03bf\u03ba\u03cd\u03c0\u03c4\u03b5\u03b9 \u03bc\u03b5 \u03c3\u03b1\u03c6\u03ae\u03bd\u03b5\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03bf \u03bb\u03cc\u03b3\u03bf \u03b1\u03c5\u03c4\u03cc\u03bd \u03b1\u03c0\u03b1\u03b9\u03c4\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c0\u03b5\u03c1\u03b1\u03b9\u03c4\u03ad\u03c1\u03c9 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2, \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03ac\u03bd \u03bf\u03b9 \u03cc\u03c0\u03bf\u03b9\u03b5\u03c2 \u03b5\u03ba\u03b4\u03b7\u03bb\u03ce\u03c3\u03b5\u03b9\u03c2 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03b7\u03c2 TSH.<\/p>\n \u0391\u03bd\u03b1\u03c6\u03bf\u03c1\u03b9\u03ba\u03ac \u03c4\u03ad\u03bb\u03bf\u03c2 \u03bc\u03b5 \u03c4\u03b9\u03c2 \u03c0\u03b9\u03b8\u03b1\u03bd\u03ad\u03c2 \u03c8\u03c5\u03c7\u03b9\u03ba\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03bd\u03bf\u03b7\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b5\u03c0\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c4\u03bf\u03c5 \u03a5\u03a5\u0398 \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1 \u03c0\u03bf\u03c5 \u03c5\u03c0\u03bf\u03c3\u03c4\u03b7\u03c1\u03af\u03b6\u03bf\u03c5\u03bd \u03b5\u03c0\u03b9\u03b4\u03b5\u03af\u03bd\u03c9\u03c3\u03b7 \u03c0\u03c1\u03bf\u03cb\u03c0\u03b1\u03c1\u03c7\u03bf\u03c5\u03c3\u03ce\u03bd \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ce\u03bd \u03cc\u03c0\u03c9\u03c2 \u03b7 \u03ba\u03b1\u03c4\u03ac\u03b8\u03bb\u03b9\u03c8\u03b7, \u03bf\u03b9 \u03b4\u03b9\u03c0\u03bf\u03bb\u03b9\u03ba\u03ad\u03c2 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ad\u03c2 \u03ba\u03b1\u03b8\u03ce\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03c5\u03c4\u03ae\u03c2 \u03ba\u03b1\u03b8\u03b5\u03b1\u03c5\u03c4\u03ae\u03c2 \u03c4\u03b7\u03c2 \u03bd\u03bf\u03b7\u03c4\u03b9\u03ba\u03ae\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 \u03c4\u03bf\u03c5 (92). \u03a3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ae \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03ad\u03b4\u03b5\u03b9\u03be\u03b5 \u03c3\u03c5\u03c3\u03c7\u03ad\u03c4\u03b9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03a5\u03a5\u0398 \u03bc\u03b5 \u03b1\u03b3\u03c7\u03ce\u03b4\u03b5\u03b9\u03c2 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ad\u03c2, \u03ba\u03b1\u03c4\u03ac\u03b8\u03bb\u03b9\u03c8\u03b7 \u03ba\u03b1\u03b9 \u03b5\u03ba\u03b4\u03b7\u03bb\u03ce\u03c3\u03b5\u03b9\u03c2 \u03bd\u03bf\u03b7\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2 \u03c3\u03b5 \u03b7\u03bb\u03b9\u03ba\u03b9\u03c9\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 (93).<\/p>\n 5.6. \u0395\u03c0\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03a5\u03a5\u0398 \u03c3\u03b5 \u03b3\u03bf\u03bd\u03b9\u03bc\u03cc\u03c4\u03b7\u03c4\u03b1, \u03ba\u03cd\u03b7\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03b5\u03be\u03ad\u03bb\u03b9\u03be\u03b7 \u03c4\u03b7\u03c2 \u03ba\u03cd\u03b7\u03c3\u03b7\u03c2 <\/b><\/h5>\n\u03a4\u03cc\u03c3\u03bf \u03bf\u03b9 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ad\u03c2 \u03c4\u03b7\u03c2 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2 (\u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03c5\u03c0\u03bf\u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2), \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03b1 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03bd\u03bf\u03c3\u03ae\u03bc\u03b1\u03c4\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c3\u03c5\u03c7\u03bd\u03ac \u03c3\u03c4\u03b9\u03c2 \u03b3\u03c5\u03bd\u03b1\u03af\u03ba\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03bc\u03ac\u03bb\u03b9\u03c3\u03c4\u03b1 \u03c3\u03c4\u03b7\u03bd \u03b1\u03bd\u03b1\u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03b9\u03ba\u03ae \u03b7\u03bb\u03b9\u03ba\u03af\u03b1 \u03c4\u03bf\u03c5\u03c2 (0,5 – 5,0%), \u03b7 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 \u03c4\u03bf\u03c5\u03c2 \u03b4\u03b5 \u03ad\u03c7\u03b5\u03b9 \u03c3\u03c5\u03c3\u03c7\u03b5\u03c4\u03b9\u03c3\u03b8\u03b5\u03af \u03bc\u03b5 \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c3\u03c4\u03b7\u03bd \u03ba\u03cd\u03b7\u03c3\u03b7 (1,8,94,95). \u0395\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd, \u03b7 \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03b7 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03af\u03c4\u03b9\u03b4\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03c4\u03b7 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b5\u03c1\u03b7 \u03b1\u03b9\u03c4\u03af\u03b1 \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1\u03c2 \u03ae \u03c0\u03bb\u03b7\u03bc\u03bc\u03b5\u03bb\u03ce\u03c2 \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03c9\u03c0\u03b9\u03b6\u03cc\u03bc\u03b5\u03bd\u03bf\u03c5 \u03c5\u03c0\u03bf\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03c3\u03bc\u03bf\u03cd \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7 \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 \u03ba\u03cd\u03b7\u03c3\u03b7\u03c2 (1,94,96). \u038c\u03c0\u03c9\u03c2 \u03c0\u03c1\u03bf\u03ba\u03cd\u03c0\u03c4\u03b5\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1 \u03b4\u03cd\u03bf \u03b1\u03bd\u03b1\u03c3\u03ba\u03bf\u03c0\u03ae\u03c3\u03b5\u03c9\u03bd \/ \u03bc\u03b5\u03c4\u03b1-\u03b1\u03bd\u03b1\u03bb\u03cd\u03c3\u03b5\u03c9\u03bd \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ce\u03bd \u03bc\u03b5\u03bb\u03b5\u03c4\u03ce\u03bd \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1 \u03c4\u03b7\u03c2 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae\u03c2 \u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03bf\u03c3\u03af\u03b1\u03c2 \u03c3\u03c4\u03b7\u03bd \u03b5\u03be\u03ad\u03bb\u03b9\u03be\u03b7 \u03c4\u03b7\u03c2 \u03ba\u03cd\u03b7\u03c3\u03b7\u03c2, \u03b4\u03b9\u03b1\u03c0\u03b9\u03c3\u03c4\u03ce\u03b8\u03b7\u03ba\u03b5 \u03cc\u03c4\u03b9 \u03bf \u03a5\u03a5\u0398 \u03c3\u03c4\u03b7\u03bd \u03c0\u03c1\u03ce\u03b9\u03bc\u03b7 \u03c6\u03ac\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03ba\u03cd\u03b7\u03c3\u03b7\u03c2 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c0\u03c1\u03bf\u03b5\u03ba\u03bb\u03b1\u03bc\u03c8\u03af\u03b1 \u03ba\u03b1\u03b9 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03c0\u03b5\u03c1\u03b9\u03b3\u03b5\u03bd\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae \u03b8\u03bd\u03b7\u03c3\u03b9\u03bc\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c3\u03b5 \u03c3\u03c7\u03ad\u03c3\u03b7 \u03bc\u03b5 \u03b5\u03c5\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ad\u03c2 \u03b3\u03c5\u03bd\u03b1\u03af\u03ba\u03b5\u03c2. \u0395\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd, \u03b7 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae\u03c2 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03bf\u03c3\u03af\u03b1\u03c2 \u03c3\u03c5\u03c3\u03c7\u03b5\u03c4\u03af\u03c3\u03b8\u03b7\u03ba\u03b5 \u03bc\u03b5 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03c5\u03c0\u03bf\u03b3\u03bf\u03bd\u03b9\u03bc\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2, \u03ba\u03b1\u03b8\u2019 \u03ad\u03be\u03b9\u03bd \u03b1\u03c0\u03bf\u03b2\u03bf\u03bb\u03ce\u03bd, \u03c0\u03c1\u03cc\u03c9\u03c1\u03c9\u03bd \u03c4\u03bf\u03ba\u03b5\u03c4\u03ce\u03bd \u03ba\u03b1\u03b9 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03af\u03c4\u03b9\u03b4\u03b1\u03c2 \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7 \u03bb\u03bf\u03c7\u03b5\u03af\u03b1 \u03c3\u03b5 \u03c3\u03c7\u03ad\u03c3\u03b7 \u03bc\u03b5 \u03bc\u03ac\u03c1\u03c4\u03c5\u03c1\u03b5\u03c2 \u03c7\u03c9\u03c1\u03af\u03c2 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03bf\u03c3\u03af\u03b1 (97). \u0395\u03c0\u03af\u03c3\u03b7\u03c2 \u03ba\u03b1\u03c4\u03b1\u03b4\u03b5\u03af\u03c7\u03b8\u03b7\u03ba\u03b5 \u03cc\u03c4\u03b9 \u03bf\u03b9 \u03ad\u03b3\u03ba\u03c5\u03b5\u03c2 \u03bc\u03b5 \u03a5\u03a5\u0398 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c4\u03c1\u03b9\u03c0\u03bb\u03ac\u03c3\u03b9\u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03b1\u03c0\u03bf\u03b2\u03bf\u03bb\u03ae\u03c2 \u03ba\u03b1\u03b9 \u03b4\u03b9\u03c0\u03bb\u03ac\u03c3\u03b9\u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03c0\u03c1\u03cc\u03c9\u03c1\u03bf\u03c5 \u03c4\u03bf\u03ba\u03b5\u03c4\u03bf\u03cd \u03cc\u03c4\u03b1\u03bd \u03c3\u03c5\u03bd\u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03bf\u03c3\u03af\u03b1 (98).<\/p>\n \u03a4\u03ad\u03bb\u03bf\u03c2 \u03c5\u03c0\u03bf\u03c3\u03c4\u03b7\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03b7 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 \u03b1\u03b8\u03b5\u03c1\u03ac\u03c0\u03b5\u03c5\u03c4\u03bf\u03c5 \u03a5\u03a5\u0398 \u03c3\u03c4\u03b7 \u03bc\u03b7\u03c4\u03ad\u03c1\u03b1 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03bf \u03b4\u03b5\u03af\u03ba\u03c4\u03b7 \u03b5\u03c5\u03c6\u03c5\u0390\u03b1\u03c2 \u03c4\u03bf\u03c5 \u03c0\u03b1\u03b9\u03b4\u03b9\u03bf\u03cd (1,8,96). \u03a0\u03b1\u03b9\u03b4\u03b9\u03ac \u03c0\u03bf\u03c5 \u03b3\u03b5\u03bd\u03bd\u03ae\u03b8\u03b7\u03ba\u03b1\u03bd \u03b1\u03c0\u03cc \u03bc\u03b7\u03c4\u03ad\u03c1\u03b5\u03c2 \u03bc\u03b5 \u03a5\u03a5\u0398, \u03c5\u03c0\u03bf\u03b8\u03c5\u03c1\u03bf\u03be\u03b9\u03bd\u03b1\u03b9\u03bc\u03af\u03b1 \u03ba\u03b1\u03b9 \u03b8\u03b5\u03c4\u03b9\u03ba\u03ac \u03b1\u03bd\u03c4\u03b9\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03b6\u03b1\u03bd \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03bf \u03b4\u03b5\u03af\u03ba\u03c4\u03b7 \u03b5\u03c5\u03c6\u03c5\u0390\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03ba\u03b9\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2 \u03c3\u03b5 \u03c3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03b1\u03c5\u03c4\u03ac \u03c0\u03bf\u03c5 \u03b3\u03b5\u03bd\u03bd\u03ae\u03b8\u03b7\u03ba\u03b1\u03bd \u03b1\u03c0\u03cc \u03bc\u03b7\u03c4\u03ad\u03c1\u03b5\u03c2 \u03c7\u03c9\u03c1\u03af\u03c2 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03bf\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1 \u03ae \u03b5\u03c0\u03b1\u03c1\u03ba\u03ce\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03cc\u03bc\u03b5\u03bd\u03b5\u03c2 (96,99).<\/p>\n \u0391\u03bd\u03b1\u03c6\u03bf\u03c1\u03b9\u03ba\u03ac \u03c4\u03ad\u03bb\u03bf\u03c2 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b8\u03ad\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03c5\u03c0\u03bf\u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7\u03c2 \u03bc\u03b5 LT4 \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b5\u03af \u03c0\u03c1\u03bf\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03ac \u03ba\u03b1\u03b9 \u03b5\u03c5\u03bd\u03bf\u03ca\u03ba\u03ac (1,8,94,96).<\/p>\n 6. \u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03ce\u03c0\u03b9\u03c3\u03b7 \u03a5\u03a5\u0398<\/b><\/h4>\n\u03a5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03b1\u03ba\u03cc\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03c3\u03ae\u03bc\u03b5\u03c1\u03b1 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03b4\u03b9\u03c7\u03bf\u03b3\u03bd\u03c9\u03bc\u03af\u03b1 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5 \u03c4\u03bf \u03c0\u03bf\u03b9\u03bf\u03b9 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03a5\u03a5\u0398 \u03b8\u03b1 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03c9\u03c0\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ac (3,4). \u039f\u03b9 \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03c3\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c0\u03b1\u03c1\u03b1\u03c4\u03ae\u03c1\u03b7\u03c3\u03b7\u03c2 \u03b4\u03b5 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03b4\u03ce\u03c3\u03bf\u03c5\u03bd \u03c3\u03b1\u03c6\u03b5\u03af\u03c2 \u03ba\u03b1\u03c4\u03b5\u03c5\u03b8\u03cd\u03bd\u03c3\u03b5\u03b9\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03bf \u03b8\u03ad\u03bc\u03b1 \u03c4\u03b7\u03c2 \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03ce\u03c0\u03b9\u03c3\u03b7\u03c2, \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c3\u03c4\u03b1 \u03b7\u03bb\u03b9\u03ba\u03b9\u03c9\u03bc\u03ad\u03bd\u03b1 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03cc\u03c0\u03bf\u03c5 \u03bf \u03a5\u03a5\u0398 \u03c3\u03c5\u03bd\u03b1\u03bd\u03c4\u03ac\u03c4\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b5\u03c1\u03b1.<\/p>\n \u039f\u03c0\u03c9\u03c3\u03b4\u03ae\u03c0\u03bf\u03c4\u03b5 \u03b1\u03c0\u03b1\u03b9\u03c4\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c4\u03c5\u03c7\u03b1\u03b9\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03b5\u03bb\u03b5\u03b3\u03c7\u03cc\u03bc\u03b5\u03bd\u03b5\u03c2 \u03bc\u03b5 \u03bc\u03ac\u03c1\u03c4\u03c5\u03c1\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2, \u03b3\u03b9\u03b1 \u03c0\u03b1\u03c1\u03ac\u03b4\u03b5\u03b9\u03b3\u03bc\u03b1 \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03b4\u03b5\u03b9\u03c7\u03b8\u03bf\u03cd\u03bd \u03c4\u03b1 \u03bf\u03c6\u03ad\u03bb\u03b7 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7\u03c2 LT4 \u03c3\u03b5 \u03c3\u03c7\u03ad\u03c3\u03b7 \u03bc\u03b5 \u03b5\u03b9\u03ba\u03bf\u03bd\u03b9\u03ba\u03cc \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03a5\u03a5\u0398 \u03ba\u03b1\u03b9 \u039a\u0391\u039d \u03bc\u03b5 \u03c4\u03b5\u03bb\u03b9\u03ba\u03cc \u03c3\u03c4\u03cc\u03c7\u03bf \u03c4\u03b7 \u03bd\u03bf\u03c3\u03b7\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03b8\u03bd\u03b7\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b1\u03c0\u03cc \u039a\u0391\u039d \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c3\u03b5 \u03b7\u03bb\u03b9\u03ba\u03b9\u03c9\u03bc\u03ad\u03bd\u03b1 \u03ac\u03c4\u03bf\u03bc\u03b1, \u03c0\u03c1\u03bf\u03ba\u03b5\u03b9\u03bc\u03ad\u03bd\u03bf\u03c5 \u03bd\u03b1 \u03b5\u03be\u03b1\u03c7\u03b8\u03bf\u03cd\u03bd \u03b1\u03c3\u03c6\u03b1\u03bb\u03ae \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03ac\u03c3\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03c4\u03b5\u03b8\u03bf\u03cd\u03bd \u03c3\u03b1\u03c6\u03b5\u03af\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2. \u03a0\u03c1\u03bf\u03c2 \u03c4\u03bf \u03c0\u03b1\u03c1\u03cc\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03bc\u03cc\u03bd\u03bf \u03bc\u03b9\u03b1 \u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 \u03c0\u03bf\u03c5 \u03b4\u03b5\u03af\u03c7\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03b7 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 LT4 \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03bf \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ae\u03c2 \u03b8\u03bd\u03b7\u03c3\u03b9\u03bc\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c3\u03b5 10% \u03b1\u03c0\u03cc 31% \u03c3\u03c4\u03b7\u03bd \u03bf\u03bc\u03ac\u03b4\u03b1 \u03c0\u03bf\u03c5 \u03b4\u03b5\u03bd \u03c7\u03bf\u03c1\u03b7\u03b3\u03ae\u03b8\u03b7\u03ba\u03b5 (62). \u03a9\u03c3\u03c4\u03cc\u03c3\u03bf \u03b7 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03b5\u03c0\u03b9\u03b4\u03ad\u03c7\u03b5\u03c4\u03b1\u03b9 \u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae\u03c2 \u03bb\u03cc\u03b3\u03c9 \u03c4\u03bf\u03c5 \u03bc\u03b9\u03ba\u03c1\u03bf\u03cd \u03b1\u03c1\u03b9\u03b8\u03bc\u03bf\u03cd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03c0\u03bf\u03c5 \u03ad\u03bb\u03b1\u03b2\u03b1\u03bd LT4.<\/p>\n \u0395\u03c0\u03b5\u03b9\u03b4\u03ae \u03cc\u03c0\u03c9\u03c2 \u03b1\u03bd\u03b1\u03c6\u03ad\u03c1\u03b8\u03b7\u03ba\u03b5, \u03c0\u03b1\u03c1\u03b5\u03bc\u03b2\u03b1\u03af\u03bd\u03bf\u03c5\u03bd \u03b4\u03b9\u03ac\u03c6\u03bf\u03c1\u03bf\u03b9 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2 \u03c3\u03c4\u03b7\u03bd \u03c4\u03b9\u03bc\u03ae \u03c4\u03b7\u03c2 TSH \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03c4\u03c9\u03bd \u03bf\u03c0\u03bf\u03af\u03c9\u03bd \u03ba\u03b1\u03b9 \u03b7 \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03c4\u03b7\u03c2 \u03b4\u03b9\u03b1\u03ba\u03cd\u03bc\u03b1\u03bd\u03c3\u03b7, \u03c0\u03c1\u03b9\u03bd \u03b1\u03c0\u03bf\u03c6\u03b1\u03c3\u03b9\u03c3\u03b8\u03b5\u03af \u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03ae \u03bc\u03b7 \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03ce\u03c0\u03b9\u03c3\u03b7 \u03b8\u03b1 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03b9\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b5\u03c0\u03b9\u03bc\u03ad\u03bd\u03bf\u03bd\u03c4\u03bf\u03c2 \u03a5\u03a5\u0398 (100). \u0397 \u03b1\u03c0\u03cc\u03c6\u03b1\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03ce\u03c0\u03b9\u03c3\u03b7 \u03b5\u03be\u03b1\u03c1\u03c4\u03ac\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03bc\u03b5\u03b3\u03ac\u03bb\u03bf \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03c4\u03b9\u03bc\u03ae \u03c4\u03b7\u03c2 TSH, \u03b5\u03ac\u03bd \u03b2\u03c1\u03af\u03c3\u03ba\u03b5\u03c4\u03b1\u03b9 \u03b4\u03b7\u03bb\u03b1\u03b4\u03ae \u03bc\u03b5\u03c4\u03b1\u03be\u03cd 3 – 5 mU\/L, 5,1 – 10 mU\/L \u03ae >10 mU\/L.<\/p>\n 6.1. \u03a5\u03c0\u03bf\u03bf\u03bc\u03ac\u03b4\u03b1 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03bc\u03b5 \u03c4\u03b9\u03bc\u03ae <\/b>TSH<\/b>>10,0 <\/b>mU<\/b>\/<\/b>L<\/b><\/h5>\nH \u03c0\u03bb\u03b5\u03b9\u03bf\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03c9\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03bf\u03bb\u03cc\u03b3\u03c9\u03bd-\u03b5\u03bd\u03b4\u03bf\u03ba\u03c1\u03b9\u03bd\u03bf\u03bb\u03cc\u03b3\u03c9\u03bd \u03c3\u03c5\u03c3\u03c4\u03ae\u03bd\u03b5\u03b9 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03ce\u03c0\u03b9\u03c3\u03b7 \u03cc\u03bb\u03c9\u03bd \u03c4\u03c9\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03b1\u03c5\u03c4\u03ae\u03c2 \u03c4\u03b7\u03c2 \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b1\u03c2 (1,4,6-8). \u038c\u03c0\u03c9\u03c2 \u03ae\u03b4\u03b7 \u03b1\u03bd\u03b1\u03c6\u03ad\u03c1\u03b8\u03b7\u03ba\u03b5 \u03bf\u03b9 \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c4\u03bf\u03c5 \u03a5\u03a5\u0398 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b9\u03bf \u03c3\u03bf\u03b2\u03b1\u03c1\u03ad\u03c2 \u03c3\u03b5 \u03b1\u03c5\u03c4\u03ae\u03bd \u03c4\u03b7\u03bd \u03c5\u03c0\u03bf-\u03bf\u03bc\u03ac\u03b4\u03b1 \u03ba\u03b1\u03b9 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b1 \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03bf\u03c2 \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2 \u03b5\u03be\u03ad\u03bb\u03b9\u03be\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03a5\u03a5\u0398 \u03c3\u03b5 \u03ad\u03ba\u03b4\u03b7\u03bb\u03bf \u03c5\u03c0\u03bf\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03c3\u03bc\u03cc (14,34-36), \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf\u03b9 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03b9\u03bf \u03c3\u03c5\u03c7\u03bd\u03ac \u03c3\u03c5\u03bc\u03c0\u03c4\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03bf\u03af (101), \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03bf\u03c5\u03bd \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b5\u03c1\u03b1 \u03b4\u03c5\u03c3\u03bb\u03b9\u03c0\u03b9\u03b4\u03b1\u03b9\u03bc\u03af\u03b1 (54), \u03cc\u03c0\u03c9\u03c2 \u03ba\u03b1\u03b9 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ae \u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03bc\u03b5 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u039a\u0391\u039d (67-69) \u03ba\u03b1\u03b9 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03ba\u03ae\u03c2 \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1\u03c2 (64, 102). \u03a4\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ce\u03bd \u03bc\u03b5\u03bb\u03b5\u03c4\u03ce\u03bd \u03b4\u03b5\u03af\u03c7\u03bd\u03bf\u03c5\u03bd \u03cc\u03c4\u03b9 \u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 LT4 \u03ad\u03c7\u03b5\u03b9 \u03c9\u03c2 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c9\u03c2 8 mg \u03c4\u03b7\u03c2 LDL-\u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2 (54, 101). \u039c\u03b5\u03c4\u03b1\u03be\u03cd \u03c4\u03c9\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03cc\u03bd\u03c4\u03c9\u03bd \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03b4\u03b9\u03b1\u03b3\u03c1\u03ac\u03c6\u03bf\u03c5\u03bd \u03cc\u03c6\u03b5\u03bb\u03bf\u03c2 \u03c3\u03c4\u03bf \u03bb\u03b9\u03c0\u03b9\u03b4\u03b1\u03b9\u03bc\u03b9\u03ba\u03cc \u2018\u03c0\u03c1\u03bf\u03c6\u03af\u03bb\u2019 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 LT4 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c4\u03b1 \u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 TSH, \u03b7 \u03b9\u03bd\u03c3\u03bf\u03c5\u03bb\u03b9\u03bd\u03bf\u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03b1\u03c3\u03b7, \u03c4\u03b1 \u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b1 \u03b1\u03c1\u03c7\u03b9\u03ba\u03ac \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03bf\u03bb\u03b9\u03ba\u03ae\u03c2 \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2 \u03ba\u03b1\u03b8\u03ce\u03c2 \u03ba\u03b1\u03b9 \u03b7 \u03c5\u03c0\u03b5\u03c1\u03c4\u03c1\u03b9\u03b3\u03bb\u03c5\u03ba\u03b5\u03c1\u03b9\u03b4\u03b1\u03b9\u03bc\u03af\u03b1 \u03c4\u03cd\u03c0\u03bf\u03c5 I I I.<\/p>\n \u0397 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 LT4 \u03ba\u03c1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03ac\u03bb\u03bb\u03bf\u03bd \u03b1\u03bd\u03b1\u03b3\u03ba\u03b1\u03af\u03b1 \u03c3\u03b5 \u03bd\u03b5\u03b1\u03c1\u03cc\u03c4\u03b5\u03c1\u03b7\u03c2 \u03b7\u03bb\u03b9\u03ba\u03af\u03b1\u03c2 \u03ac\u03c4\u03bf\u03bc\u03b1 (<65 \u03ad\u03c4\u03b7) \u03bc\u03b5 \u03c3\u03ba\u03bf\u03c0\u03cc \u03c4\u03b7\u03bd \u03c0\u03c1\u03cc\u03bb\u03b7\u03c8\u03b7 \u03ad\u03ba\u03b4\u03b7\u03bb\u03bf\u03c5 \u03c5\u03c0\u03bf\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b4\u03b9\u03c3\u03bc\u03bf\u03cd, \u03c4\u03b7\u03bd \u03b5\u03be\u03ac\u03bb\u03b5\u03b9\u03c8\u03b7 \u03c4\u03c9\u03bd \u03c3\u03c5\u03bc\u03c0\u03c4\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd, \u03c4\u03b7 \u03b2\u03b5\u03bb\u03c4\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c0\u03bf\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03b6\u03c9\u03ae\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03c0\u03c1\u03cc\u03bb\u03b7\u03c8\u03b7 \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7\u03c2 \u039a\u0391\u039d \u03ba\u03b1\u03b9 \u03b8\u03bd\u03b7\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 (62, 102). \u038c\u03c0\u03c9\u03c2 \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b5\u03c0\u03b1\u03bd\u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03c9\u03bd \u03c4\u03b7\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7\u03c2 Wickham \u03b7 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 LT4 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03a5\u03a5\u0398 \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03c4\u03b7\u03bd \u03bf\u03bb\u03b9\u03ba\u03ae \u03b8\u03bd\u03b7\u03c3\u03b9\u03bc\u03cc\u03c4\u03b7\u03c4\u03b1 (62).<\/p>\n \u03a4\u03ad\u03bb\u03bf\u03c2 \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1 \u03c0\u03bf\u03c5 \u03b4\u03b5\u03af\u03c7\u03bd\u03bf\u03c5\u03bd \u03cc\u03c4\u03b9 \u03b7 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 LT4 \u03c3\u03c5\u03bd\u03bf\u03b4\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03b2\u03b5\u03bb\u03c4\u03af\u03c9\u03c3\u03b7 \u03bd\u03b5\u03c5\u03c1\u03bf\u03bc\u03c5\u03b9\u03ba\u03ce\u03bd, \u03c8\u03c5\u03c7\u03b9\u03ba\u03ce\u03bd \u03ba\u03b1\u03b9 \u03bd\u03bf\u03b7\u03c4\u03b9\u03ba\u03ce\u03bd \u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ce\u03bd \u03c0\u03bf\u03c5 \u03b5\u03c0\u03b9\u03b4\u03b5\u03b9\u03bd\u03ce\u03bd\u03bf\u03c5\u03bd \u03c4\u03bf\u03bd \u03a5\u03a5\u0398 (46,51,87,101,103).<\/p>\n 6.2. \u03a5\u03c0\u03bf-\u03bf\u03bc\u03ac\u03b4\u03b1 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03bc\u03b5 \u03c4\u03b9\u03bc\u03ae <\/b>TSH<\/b> \u03bc\u03b5\u03c4\u03b1\u03be\u03cd 5,1-10 <\/b>mU<\/b>\/<\/b>L<\/b><\/h5>\n\u03a3\u03b5 \u03b1\u03bd\u03c4\u03af\u03b8\u03b5\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03c0\u03c1\u03bf\u03b7\u03b3\u03bf\u03cd\u03bc\u03b5\u03bd\u03b7 \u03c0\u03b9\u03bf \u2018\u03c3\u03bf\u03b2\u03b1\u03c1\u03ae\u2019 \u03c5\u03c0\u03bf\u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b1 \u03a5\u03a5\u0398, \u03b4\u03b5\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03bf\u03bc\u03bf\u03c6\u03c9\u03bd\u03af\u03b1 \u03c4\u03cc\u03c3\u03bf \u03c3\u03c4\u03b9\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b5\u03c0\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03c3\u03c4\u03bf \u03b5\u03bd\u03b4\u03b5\u03c7\u03cc\u03bc\u03b5\u03bd\u03bf \u03cc\u03c6\u03b5\u03bb\u03bf\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 LT4 \u03c3\u03b5 \u03b1\u03c5\u03c4\u03ae \u03c4\u03b7\u03bd \u03bf\u03bc\u03ac\u03b4\u03b1 \u2018\u03ae\u03c0\u03b9\u03bf\u03c5\u2019 \u03a5\u03a5\u0398 (1,3,4,8). \u0397 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03ae \u03bc\u03b7 \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03ce\u03c0\u03b9\u03c3\u03b7 \u03b5\u03be\u03b1\u03c4\u03bf\u03bc\u03b9\u03ba\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03b4\u03b9\u03ac\u03c6\u03bf\u03c1\u03bf\u03c5\u03c2 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2 \u2018\u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5\u2019 \u03cc\u03c0\u03c9\u03c2 \u03b7 \u03b7\u03bb\u03b9\u03ba\u03af\u03b1, \u03b7 \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b5\u03be\u03ad\u03bb\u03b9\u03be\u03b7\u03c2 \u03c3\u03b5 \u03ad\u03ba\u03b4\u03b7\u03bb\u03b7 \u03bd\u03cc\u03c3\u03bf, \u03b7 \u03c0\u03bf\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b6\u03c9\u03ae\u03c2 \u03b7 \u03c3\u03c5\u03bd\u03bf\u03c3\u03b7\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03ac\u03bb\u03bb\u03bf\u03b9 \u03bd\u03bf\u03b7\u03c4\u03b9\u03ba\u03bf\u03af, \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03bf\u03af \u03ba\u03b1\u03b9 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03ba\u03bf\u03af \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2 (1,8). \u039d\u03b5\u03b1\u03c1\u03ad\u03c2 \u03b3\u03c5\u03bd\u03b1\u03af\u03ba\u03b5\u03c2 \u03b1\u03bd\u03b1\u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03b9\u03ba\u03ae\u03c2 \u03b7\u03bb\u03b9\u03ba\u03af\u03b1\u03c2 \u03bc\u03b5 \u03c3\u03c5\u03bd\u03cd\u03c0\u03b1\u03c1\u03be\u03b7 \u03b2\u03c1\u03bf\u03b3\u03c7\u03bf\u03ba\u03ae\u03bb\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 \u03b1\u03bd\u03c4\u03b9-TPO \u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03c9\u03c0\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b5\u03c1\u03b1 \u03b1\u03c0\u03cc \u03cc\u03c4\u03b9 \u03b7\u03bb\u03b9\u03ba\u03b9\u03c9\u03bc\u03ad\u03bd\u03bf\u03b9 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 (1,8,104). \u03a4\u03b1 \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03bd\u03c4\u03b1 \u03b2\u03b9\u03b2\u03bb\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03b9\u03ba\u03ac \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1, \u03c0\u03b1\u03c1\u03ac \u03c4\u03b1 \u03b1\u03bd\u03c4\u03b9\u03ba\u03c1\u03bf\u03c5\u03cc\u03bc\u03b5\u03bd\u03b1 \u03ba\u03b1\u03b9 \u03b5\u03c0\u03b1\u03bc\u03c6\u03bf\u03c4\u03b5\u03c1\u03af\u03b6\u03bf\u03bd\u03c4\u03b1 \u03b5\u03c5\u03c1\u03ae\u03bc\u03b1\u03c4\u03ac \u03c4\u03bf\u03c5\u03c2, \u03b4\u03b5\u03af\u03c7\u03bd\u03bf\u03c5\u03bd \u03b5\u03bd\u03b4\u03b5\u03c7\u03cc\u03bc\u03b5\u03bd\u03bf \u03cc\u03c6\u03b5\u03bb\u03bf\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 LT4 \u03c3\u03b5 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b5\u03c2 \u03c3\u03c5\u03bc\u03c0\u03c4\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03c0\u03bf\u03c5 \u03c3\u03c5\u03bd\u03bf\u03c8\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf\u03bd \u03c0\u03af\u03bd\u03b1\u03ba\u03b1 9<\/b> (1,8,19,46,47,87,101,103-110). \u039c\u03b5 \u03c4\u03bf \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03bf \u03cc\u03c4\u03b9 \u03c0\u03b1\u03b9\u03b4\u03b9\u03ac \u03c0\u03bf\u03c5 \u03b3\u03b5\u03bd\u03bd\u03ae\u03b8\u03b7\u03ba\u03b1\u03bd \u03b1\u03c0\u03cc \u03bc\u03b7\u03c4\u03ad\u03c1\u03b5\u03c2 \u03bc\u03b5 \u03a5\u03a5\u0398 \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7 \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 \u03ba\u03cd\u03b7\u03c3\u03b7\u03c2 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03bf\u03c5\u03bd \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03bf \u03b4\u03b5\u03af\u03ba\u03c4\u03b7 \u03b5\u03c5\u03c6\u03c5\u0390\u03b1\u03c2 (99) \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03ae\u03c0\u03b9\u03bf\u03c5 \u03a5\u03a5\u0398 \u03c3\u03c4\u03b7\u03bd \u03ad\u03ba\u03b2\u03b1\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03ba\u03cd\u03b7\u03c3\u03b7\u03c2 \u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 LT4 \u03ba\u03c1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03bd\u03b1\u03b3\u03ba\u03b1\u03af\u03b1 \u03c3\u03b5 \u03ad\u03b3\u03ba\u03c5\u03b5\u03c2 \u03ae \u03b3\u03c5\u03bd\u03b1\u03af\u03ba\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03b5\u03c0\u03b9\u03b8\u03c5\u03bc\u03bf\u03cd\u03bd \u03bd\u03b1 \u03c4\u03b5\u03ba\u03bd\u03bf\u03c0\u03bf\u03b9\u03ae\u03c3\u03bf\u03c5\u03bd \u03ac\u03bc\u03b5\u03c3\u03b1. \u0391\u03bd\u03ac\u03bb\u03bf\u03b3\u03b7 \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03ce\u03c0\u03b9\u03c3\u03b7 \u03b8\u03b1 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03c0\u03b1\u03b9\u03b4\u03b9\u03ac \u03ae \u03bf\u03b9 \u03ad\u03c6\u03b7\u03b2\u03bf\u03b9 \u03bc\u03b5 \u03a5\u03a5\u0398 \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03bf\u03c1\u03bc\u03bf\u03bc\u03ce\u03bd \u03c3\u03c4\u03b7\u03bd \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7. \u03a4\u03ad\u03bb\u03bf\u03c2, \u03c3\u03c4\u03b7\u03bd \u03c5\u03c0\u03bf\u03bf\u03bc\u03ac\u03b4\u03b1 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03bc\u03b5 TSH > 8 mU\/L \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b7 \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b5\u03be\u03ad\u03bb\u03b9\u03be\u03b7\u03c2 \u03c3\u03b5 \u03c0\u03b9\u03bf \u03c3\u03bf\u03b2\u03b1\u03c1\u03cc \u03a5\u03a5\u0398 \u03c4\u03b1 \u03b5\u03c0\u03cc\u03bc\u03b5\u03bd\u03b1 4 \u03ad\u03c4\u03b7 \u03ba\u03b1\u03b9 \u03c9\u03c2 \u03b5\u03ba \u03c4\u03bf\u03cd\u03c4\u03bf\u03c5 \u03b8\u03b1 \u03b5\u03af\u03c7\u03b5 \u03b5\u03bd\u03b4\u03b5\u03c7\u03bf\u03bc\u03ad\u03bd\u03c9\u03c2 \u03ba\u03b1\u03b9 \u03b5\u03b4\u03ce \u03ad\u03bd\u03b4\u03b5\u03b9\u03be\u03b7 \u03b7 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 LT4 (19).<\/p>\n \u03a0\u03af\u03bd\u03b1\u03ba\u03b1\u03c2 9.<\/b> \u039a\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03c3\u03c4\u03b9\u03c2 \u03bf\u03c0\u03bf\u03af\u03b5\u03c2 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03ae\u03b8\u03b7\u03ba\u03b5 \u03cc\u03c6\u03b5\u03bb\u03bf\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 LT4.<\/p>\n\n\n\n| <\/td>\n<\/tr>\n | \n| \u0395\u03b3\u03ba\u03c5\u03bc\u03bf\u03c3\u03cd\u03bd\u03b7 \u03ae \u03b1\u03bd\u03b1\u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03b9\u03ba\u03ae \u03b7\u03bb\u03b9\u03ba\u03af\u03b1<\/td>\n<\/tr>\n | \n| \u0392\u03c1\u03bf\u03b3\u03c7\u03bf\u03ba\u03ae\u03bb\u03b7<\/td>\n<\/tr>\n | \n| Trial \u03b3\u03b9\u03b1 \u03c0\u03b9\u03b8\u03b1\u03bd\u03ac \u03c5\u03c0\u03bf\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1<\/td>\n<\/tr>\n | \n| \u03a0\u03c1\u03bf\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03b1\u03c3\u03b8\u03b5\u03bd\u03bf\u03cd\u03c2<\/td>\n<\/tr>\n | \n| \u03a0\u03b1\u03b9\u03b4\u03b9\u03ba\u03ae \u03b7\u03bb\u03b9\u03ba\u03af\u03b1 \u03ae \u03b5\u03c6\u03b7\u03b2\u03b5\u03af\u03b1<\/td>\n<\/tr>\n | \n| TSH > 8 mIU\/L<\/td>\n<\/tr>\n | \n| \u0394\u03b9\u03c0\u03bf\u03bb\u03b9\u03ba\u03ad\u03c2 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ad\u03c2\/ \u03ba\u03b1\u03c4\u03ac\u03b8\u03bb\u03b9\u03c8\u03b7<\/td>\n<\/tr>\n | \n| \u03a5\u03c0\u03bf\u03b3\u03bf\u03bd\u03b9\u03bc\u03cc\u03c4\u03b7\u03c4\u03b1<\/td>\n<\/tr>\n | \n| \u03a0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 \u03b1\u03bd\u03c4\u03b9\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd<\/td>\n<\/tr>\n | \n| \u03a0\u03c1\u03bf\u03bf\u03b4\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 TSH<\/td>\n<\/tr>\n | \n| \u0394\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ad\u03c2 \u03c9\u03bf\u03b8\u03c5\u03bb\u03b1\u03ba\u03b9\u03bf\u03c1\u03b7\u03be\u03af\u03b1\u03c2<\/td>\n<\/tr>\n | \n\u03a5\u03c0\u03b5\u03c1\u03bb\u03b9\u03c0\u03b9\u03b4\u03b1\u03b9\u03bc\u03af\u03b1<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n6.3. \u03a5\u03c0\u03bf-\u03bf\u03bc\u03ac\u03b4\u03b1 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03bc\u03b5 \u03c4\u03b9\u03bc\u03ae <\/b>TSH<\/b> \u03bc\u03b5\u03c4\u03b1\u03be\u03cd 3 – 5 <\/b>mU<\/b>\/<\/b>L<\/b><\/h5>\n\u0395\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 TSH \u03c3\u03b5 \u03b1\u03c5\u03c4\u03ac \u03c4\u03b1 \u03cc\u03c1\u03b9\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03ac\u03bb\u03bb\u03bf\u03bd \u03b1\u03c0\u03af\u03b8\u03b1\u03bd\u03bf \u03bd\u03b1 \u03c5\u03c0\u03bf\u03b4\u03b7\u03bb\u03ce\u03bd\u03bf\u03c5\u03bd \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae \u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03ba\u03b1\u03b9 \u03b5\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd, \u03c4\u03bf \u03cc\u03c6\u03b5\u03bb\u03bf\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 LT4 \u03c0\u03c1\u03bf\u03ba\u03b5\u03b9\u03bc\u03ad\u03bd\u03bf\u03c5 \u03bd\u03b1 \u03bc\u03b5\u03b9\u03c9\u03b8\u03bf\u03cd\u03bd \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03ac \u03c4\u03b7\u03c2 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03b5\u03ba\u03bc\u03b7\u03c1\u03b9\u03c9\u03bc\u03ad\u03bd\u03bf. \u0397 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b1\u03bd\u03c9\u03c4\u03ad\u03c1\u03c9 \u03b5\u03c0\u03b9\u03c0\u03ad\u03b4\u03c9\u03bd \u03c3\u03c4\u03b1 \u03cc\u03c1\u03b9\u03b1 \u03c4\u03c9\u03bd 3 mU\/L \u03b8\u03b1 \u03b5\u03af\u03c7\u03b5 \u03c4\u03b5\u03c1\u03ac\u03c3\u03c4\u03b9\u03bf \u03ba\u03cc\u03c3\u03c4\u03bf\u03c2 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ce\u03bd \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03c9\u03bd \u03ba\u03b1\u03b9 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03bf\u03cd \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5 \u03bc\u03b5 \u03b1\u03bc\u03c6\u03af\u03b2\u03bf\u03bb\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 (12) .<\/p>\n \u03a3\u03c4\u03b7\u03bd \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 11<\/b> \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03b9\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c7\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03c4\u03b1 \u03c0\u03c1\u03bf\u03c4\u03b5\u03b9\u03bd\u03cc\u03bc\u03b5\u03bd\u03b1 \u03b2\u03ae\u03bc\u03b1\u03c4\u03b1 \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae\u03c2 \u03ba\u03b1\u03b9 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03ce\u03c0\u03b9\u03c3\u03b7\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03bc\u03b5 \u03a5\u03a5\u0398 \u03ba\u03b1\u03b9 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c4\u03b7\u03c2 \u03c5\u03c0\u03bf-\u03bf\u03bc\u03ac\u03b4\u03b1\u03c2 \u2018\u03c0\u03bf\u03bb\u03cd \u03ae\u03c0\u03b9\u03bf\u03c5\u2019 \u03a5\u03a5\u0398. \u03a9\u03c2 \u03ba\u03cd\u03c1\u03b9\u03bf \u03ba\u03c1\u03b9\u03c4\u03ae\u03c1\u03b9\u03bf \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03b7 \u03cd\u03c0\u03b1\u03c1\u03be\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03bf\u03cd \u03bf\u03c6\u03ad\u03bb\u03bf\u03c5\u03c2 \u03ba\u03b1\u03b9 \u03b7 \u03b1\u03c0\u03bf\u03c6\u03c5\u03b3\u03ae \u03c0\u03b1\u03c1\u03b5\u03bd\u03b5\u03c1\u03b3\u03b5\u03b9\u03ce\u03bd \u03ae \u03b1\u03bd\u03b5\u03c0\u03b9\u03b8\u03cd\u03bc\u03b7\u03c4\u03c9\u03bd \u03b5\u03bd\u03b5\u03c1\u03b3\u03b5\u03b9\u03ce\u03bd. \u03a3\u03c5\u03bd\u03bf\u03c8\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03c2 \u03b8\u03b1 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03c3\u03b5 \u03bd\u03b1 \u03bb\u03b5\u03c7\u03b8\u03b5\u03af \u03cc\u03c4\u03b9 \u03b7 \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03ce\u03c0\u03b9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03a5\u03a5\u0398 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 LT4 \u03ba\u03b1\u03b9 \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03bf\u03bc\u03bf\u03c6\u03c9\u03bd\u03af\u03b1 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5 \u03c4\u03b7\u03bd \u03c5\u03c0\u03bf\u03bf\u03bc\u03ac\u03b4\u03b1 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03bc\u03b5 \u03c4\u03b9\u03bc\u03ae TSH > 10 mU\/L. \u03a3\u03c4\u03b7\u03bd \u03c5\u03c0\u03bf-\u03bf\u03bc\u03ac\u03b4\u03b1 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03bc\u03b5 \u03c4\u03b9\u03bc\u03ae TSH \u03bc\u03b5\u03c4\u03b1\u03be\u03cd 3 – 5 mU\/L \u03c0\u03c1\u03bf\u03c4\u03b5\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b5\u03be\u03b1\u03c4\u03bf\u03bc\u03af\u03ba\u03b5\u03c5\u03c3\u03b7. \u0397 \u03c3\u03c5\u03bd\u03ae\u03b8\u03b7\u03c2 \u03c3\u03c5\u03bd\u03b9\u03c3\u03c4\u03ce\u03bc\u03b5\u03bd\u03b7 \u03b4\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03ba\u03c5\u03bc\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc 25 – 75 \u03bcg \u03b7\u03bc\u03b5\u03c1\u03b7\u03c3\u03af\u03c9\u03c2 \u03bc\u03b5 \u03c4\u03b9\u03c2 \u03bc\u03b9\u03ba\u03c1\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03b4\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03af\u03b5\u03c2 \u03bd\u03b1 \u03c0\u03c1\u03bf\u03c4\u03b5\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c3\u03b5 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7\u03c2 \u03b7\u03bb\u03b9\u03ba\u03af\u03b1\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03c3\u03c5\u03bd\u03bf\u03c3\u03b7\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1. \u039f \u03b5\u03c0\u03b1\u03bd\u03b1\u03ba\u03b1\u03b8\u03bf\u03c1\u03b9\u03c3\u03bc\u03cc\u03c2 \u03c4\u03b7\u03c2 \u03c0\u03c1\u03bf\u03c4\u03b5\u03b9\u03bd\u03cc\u03bc\u03b5\u03bd\u03b7\u03c2 \u03b4\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03af\u03b1\u03c2 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03bc\u03b5\u03c3\u03bf\u03b4\u03b9\u03b1\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03b1 \u03b5\u03c0\u03b1\u03bd\u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5 \u03b4\u03cd\u03bf \u03bc\u03b7\u03bd\u03ce\u03bd \u03ba\u03b1\u03b9 \u03b5\u03c6\u03cc\u03c3\u03bf\u03bd \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03b7\u03c2 TSH \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03bf\u03cd\u03bd \u03bf \u03b5\u03c0\u03b1\u03bd\u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 6\u03bc\u03b7\u03bd\u03b9\u03b1\u03af\u03b1 \u03b2\u03ac\u03c3\u03b7. \u03a3\u03b5 \u03bd\u03b5\u03b1\u03c1\u03cc\u03c4\u03b5\u03c1\u03b7\u03c2 \u03b7\u03bb\u03b9\u03ba\u03af\u03b1\u03c2 \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03b7\u03c2 TSH \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03ba\u03c5\u03bc\u03b1\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc 0,3 \u03c9\u03c2 3 mU\/L, \u03b5\u03bd\u03ce \u03c3\u03c4\u03b1 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7\u03c2 \u03b7\u03bb\u03b9\u03ba\u03af\u03b1\u03c2 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03c3\u03b5 \u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1. \u0397 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03c3\u03c4\u03cc\u03c7\u03b5\u03c5\u03c3\u03b7 \u03bf\u03c6\u03b5\u03af\u03bb\u03b5\u03b9 \u03bd\u03b1 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03b9 \u03c5\u03c0\u03cc\u03c8\u03b7 \u03c0\u03b9\u03b8\u03b1\u03bd\u03ad\u03c2 \u03b5\u03ba\u03b4\u03b7\u03bb\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b8\u03c5\u03c1\u03b5\u03bf\u03c4\u03bf\u03be\u03af\u03ba\u03c9\u03c3\u03b7\u03c2. \u0397 \u03c3\u03c4\u03ac\u03b8\u03bc\u03b9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b5\u03c0\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03c9\u03bd \u03c4\u03bf\u03c5 \u03b1\u03b8\u03b5\u03c1\u03ac\u03c0\u03b5\u03c5\u03c4\u03bf\u03c5 \u03ae\u03c0\u03b9\u03bf\u03c5 \u03a5\u03a5\u0398 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b8\u03c5\u03c1\u03b5\u03bf\u03c4\u03bf\u03be\u03af\u03ba\u03c9\u03c3\u03b7\u03c2 \u03b5\u03c0\u03b1\u03c6\u03af\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03ba\u03c1\u03af\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b8\u03b5\u03c1\u03ac\u03c0\u03bf\u03bd\u03c4\u03bf\u03c2 \u03b9\u03b1\u03c4\u03c1\u03bf\u03cd.<\/p>\n
\n ![\"10.17image11\"](\"https:\/\/e-endocrinology.gr\/wp-content\/uploads\/2015\/02\/10.17image11.jpg\") <\/p>\n
\u00a0<\/b><\/p>\n \u0395\u03b9\u03ba\u03cc\u03bd\u03b1 11<\/b>.<\/b> \u0394\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03cc\u03c2 \u03ba\u03b1\u03b9 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03cc\u03c2 \u03b1\u03bb\u03b3\u03cc\u03c1\u03b9\u03b8\u03bc\u03bf\u03c2 \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03ce\u03c0\u03b9\u03c3\u03b7\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03bc\u03b5 \u03a5\u03a5\u0398 \u03ba\u03b1\u03b9 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c4\u03b7\u03c2 \u03c5\u03c0\u03bf-\u03bf\u03bc\u03ac\u03b4\u03b1\u03c2 \u2018\u03c0\u03bf\u03bb\u03cd \u03ae\u03c0\u03b9\u03bf\u03c5\u2019 \u03a5\u03a5\u0398.<\/p>\n
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\nCreated: February 25, 2015
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