{"id":1115,"date":"2015-02-24T12:40:44","date_gmt":"2015-02-24T09:40:44","guid":{"rendered":"http:\/\/e-endocrinology.gr\/?page_id=1115"},"modified":"2015-03-19T14:40:40","modified_gmt":"2015-03-19T11:40:40","slug":"3-11-%ce%bc%ce%bf%cf%81%ce%b9%ce%b1%ce%ba%ce%ae-%ce%b2%ce%b9%ce%bf%ce%bb%ce%bf%ce%b3%ce%af%ce%b1-%cf%84%ce%bf%cf%85-%ce%bc%cf%85%ce%b5%ce%bb%ce%bf%ce%b5%ce%b9%ce%b4%ce%bf%cf%8d%cf%82-%ce%ba%ce%b1","status":"publish","type":"page","link":"https:\/\/e-endocrinology.gr\/?page_id=1115","title":{"rendered":"3.11 \u039c\u03bf\u03c1\u03b9\u03b1\u03ba\u03ae \u0392\u03b9\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03c4\u03bf\u03c5 \u03bc\u03c5\u03b5\u03bb\u03bf\u03b5\u03b9\u03b4\u03bf\u03cd\u03c2 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5 \u03c4\u03bf\u03c5 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03bf\u03cd\u03c2"},"content":{"rendered":"<p style=\"text-align: right;\"><div class=\"printfriendly pf-button  pf-alignright\">\n                    <a href=\"https:\/\/e-endocrinology.gr\/?page_id=1115&#038;pfstyle=wp\" rel=\"nofollow\" onclick=\"\" title=\"Printer Friendly, PDF & Email\">\n                    <img decoding=\"async\" class=\"pf-button-img\" src=\"https:\/\/cdn.printfriendly.com\/buttons\/printfriendly-pdf-button-nobg.png\" alt=\"Print Friendly, PDF & Email\" style=\"width: 112px;height: 24px;\"  \/>\n                    <\/a>\n                <\/div><\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: right;\"><em>\u039b\u03ae\u03b4\u03b1 \u03a3\u03b1\u03c1\u03af\u03ba\u03b1<\/em><br \/>\n\u0392\u03b9\u03bf\u03bb\u03cc\u03b3\u03bf\u03c2<br \/>\n\u0395\u03bd\u03b4\u03bf\u03ba\u03c1\u03b9\u03bd\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u039c\u03bf\u03bd\u03ac\u03b4\u03b1 \u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae\u03c2 \u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03a0\u03b1\u03bd\u03b5\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03af\u03bf\u03c5 \u0391\u03b8\u03b7\u03bd\u03ce\u03bd<\/p>\n<p style=\"text-align: right;\"><em>\u039c\u03b1\u03c1\u03af\u03b1 \u0391\u03bb\u03b5\u03b2\u03b9\u03b6\u03ac\u03ba\u03b7<\/em><br \/>\n\u0395\u03bd\u03b4\u03bf\u03ba\u03c1\u03b9\u03bd\u03bf\u03bb\u03cc\u03b3\u03bf\u03c2<br \/>\n\u0395\u03bd\u03b4\u03bf\u03ba\u03c1\u03b9\u03bd\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u039c\u03bf\u03bd\u03ac\u03b4\u03b1 \u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae\u03c2 \u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03a0\u03b1\u03bd\u03b5\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03af\u03bf\u03c5 \u0391\u03b8\u03b7\u03bd\u03ce\u03bd<\/p>\n<h4 style=\"text-align: justify;\"><b>1. \u0395\u03b9\u03c3\u03b1\u03b3\u03c9\u03b3\u03ae<\/b><\/h4>\n<p style=\"text-align: justify;\">\u03a4\u03bf \u03bc\u03c5\u03b5\u03bb\u03bf\u03b5\u03b9\u03b4\u03ad\u03c2 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03c9\u03bc\u03b1 \u03c4\u03bf\u03c5 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03bf\u03cd\u03c2 (\u039c\u039a\u0398) \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1\u03c2 \u03c3\u03c0\u03ac\u03bd\u03b9\u03bf\u03c2 \u03ba\u03b1\u03ba\u03bf\u03ae\u03b8\u03b7\u03c2 \u03cc\u03b3\u03ba\u03bf\u03c2 \u03bf \u03bf\u03c0\u03bf\u03af\u03bf\u03c2 \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03ac\u03c6\u03b7\u03ba\u03b5 \u03b3\u03b9\u03b1 \u03c0\u03c1\u03ce\u03c4\u03b7 \u03c6\u03bf\u03c1\u03ac \u03c4\u03bf 1959 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd Hazard (Hazard et al 1959). \u0391\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03c4\u03bf 4-10% \u03c4\u03c9\u03bd \u03bd\u03b5\u03bf\u03c0\u03bb\u03b1\u03c3\u03bc\u03ac\u03c4\u03c9\u03bd \u03c4\u03bf\u03c5 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03bf\u03cd\u03c2, \u03c0\u03c1\u03bf\u03ad\u03c1\u03c7\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b1\u00a0 \u03c0\u03b1\u03c1\u03b1\u03b8\u03c5\u03bb\u03b1\u03ba\u03b9\u03ce\u03b4\u03b7 C \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c4\u03bf\u03c5 \u03b1\u03b4\u03ad\u03bd\u03b1 \u03c4\u03c9\u03bd \u03bf\u03c0\u03bf\u03af\u03c9\u03bd \u03b7 \u03b5\u03bc\u03b2\u03c1\u03c5\u03ca\u03ba\u03ae \u03c0\u03c1\u03bf\u03ad\u03bb\u03b5\u03c5\u03c3\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u00a0\u03b1\u03c0\u03cc \u03c4\u03b7 \u03bd\u03b5\u03c5\u03c1\u03b9\u03ba\u03ae \u03b1\u03ba\u03c1\u03bf\u03bb\u03bf\u03c6\u03af\u03b1 (crest). \u03a4\u03bf \u039c\u039a\u0398 \u03c0\u03b1\u03c1\u03ac\u03b3\u03b5\u03b9 \u03ba\u03b1\u03bb\u03c3\u03b9\u03c4\u03bf\u03bd\u03af\u03bd\u03b7 \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03ba\u03b1\u03b9 \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03b9\u03ba\u03cc \u03b4\u03b5\u03af\u03ba\u03c4\u03b7.<\/p>\n<p style=\"text-align: justify;\">\u03a4\u03bf 25-30% \u03c4\u03c9\u03bd \u039c\u039a\u0398 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03b9\u03ac\u03b6\u03bf\u03c5\u03bd \u03bf\u03b9\u03ba\u03bf\u03b3\u03b5\u03bd\u03ae \u03b5\u03c0\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u00a0\u03ba\u03bb\u03b7\u03c1\u03bf\u03bd\u03bf\u03bc\u03bf\u03cd\u03bc\u03b5\u03bd\u03b7 \u03bc\u03bf\u03c1\u03c6\u03ae \u03b5\u03bd\u03ce \u03c4\u03bf \u03c5\u03c0\u03cc\u03bb\u03bf\u03b9\u03c0\u03bf 70-75% \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c0\u03bf\u03c1\u03b1\u03b4\u03b9\u03ba\u03ac.<\/p>\n<h4 style=\"text-align: justify;\"><b>2. \u03a3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03b1 \u03a0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03ae\u03c2 \u0395\u03bd\u03b4\u03bf\u03ba\u03c1\u03b9\u03bd\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae\u03c2 \u039d\u03b5\u03bf\u03c0\u03bb\u03b1\u03c3\u03af\u03b1\u03c2 \u039c\u0395\u039d2<\/b><\/h4>\n<p style=\"text-align: justify;\">\u0397 \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bf\u03b9\u03ba\u03bf\u03b3\u03b5\u03bd\u03bf\u03cd\u03c2 \u03bc\u03bf\u03c1\u03c6\u03ae\u03c2\u00a0 \u039c\u039a\u0398 \u03c3\u03c5\u03bd\u03bf\u03b4\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03ac \u03ba\u03b1\u03b9 \u03b1\u03c0\u03cc \u03ac\u03bb\u03bb\u03b5\u03c2 \u03c0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03b5\u03ba\u03b4\u03b7\u03bb\u03ce\u03c3\u03b5\u03b9\u03c2 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03b5\u03bd\u03b4\u03bf\u03ba\u03c1\u03b9\u03bd\u03ce\u03bd \u03b1\u03b4\u03ad\u03bd\u03c9\u03bd \u03c3\u03b1\u03bd \u03c3\u03c5\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03cc \u03c4\u03bf\u03c5 \u03a3\u03c5\u03bd\u03b4\u03c1\u03cc\u03bc\u03bf\u03c5 \u03a0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03ae\u03c2 \u0395\u03bd\u03b4\u03bf\u03ba\u03c1\u03b9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03bd\u03b5\u03bf\u03c0\u03bb\u03b1\u03c3\u03af\u03b1\u03c2 \u039c\u0395\u039d2. \u0391\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03b1 \u03c3\u03c5\u03bd\u03bf\u03b4\u03ac \u03bd\u03bf\u03c3\u03ae\u03bc\u03b1\u03c4\u03b1\u00a0 \u03ba\u03b1\u03c4\u03b1\u03c4\u03ac\u03c3\u03c3\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03c4\u03c1\u03b5\u03af\u03c2 \u03c4\u03cd\u03c0\u03bf\u03c5\u03c2:<\/p>\n<ul style=\"text-align: justify;\">\n<li><b>\u03a4\u03bf \u03c3. \u039c\u0395\u039d2\u0391<\/b> \u03cc\u03c0\u03bf\u03c5 \u03c4\u03bf \u039c\u039a\u0398 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b1\u03c1\u03cc\u03bd \u03c3\u03c4\u03bf &gt;90% \u03c4\u03c9\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bd\u03bf\u03b4\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c6\u03b1\u03b9\u03bf\u03c7\u03c1\u03c9\u03bc\u03bf\u03ba\u03cd\u03c4\u03c4\u03c9\u03bc\u03b1 \u03c3\u03c4\u03bf 40-50% \u03c4\u03c9\u03bd \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c5\u03c0\u03b5\u03c1\u03c0\u03b1\u03c1\u03b1\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03c3\u03bc\u03cc \u03c3\u03c4\u03bf 10-20% \u03c4\u03c9\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03c3\u03c0\u03b1\u03bd\u03b9\u03cc\u03c4\u03b5\u03c1\u03b1 \u03b4\u03b5 \u03b1\u03c0\u03cc \u03b4\u03b5\u03c1\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03bb\u03b5\u03b9\u03c7\u03b7\u03bd\u03bf\u03b5\u03b9\u03b4\u03ae \u03b1\u03bc\u03c5\u03bb\u03bf\u03b5\u03af\u03b4\u03c9\u03c3\u03b7.<br \/>\n<b><\/b><\/li>\n<li><b>\u03a4\u03bf \u03c3. \u039c\u0395\u039d2\u0392<\/b> \u03c3\u03c4\u03bf \u03bf\u03c0\u03bf\u03af\u03bf \u03c4\u03bf \u03c3\u03cd\u03bd\u03bf\u03bb\u03bf \u03c3\u03c7\u03b5\u03b4\u03cc\u03bd \u03c4\u03c9\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd (~100%) \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03b9\u03ac\u03b6\u03b5\u03b9 \u039c\u039a\u0398 \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bd\u03bf\u03b4\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c6\u03b1\u03b9\u03bf\u03c7\u03c1\u03c9\u03bc\u03bf\u03ba\u03cd\u03c4\u03c4\u03c9\u03bc\u03b1 \u03c3\u03c4\u03bf 25% \u03c4\u03c9\u03bd \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03c5\u03c0\u03bf\u03b2\u03bb\u03b5\u03bd\u03bd\u03bf\u03b3\u03cc\u03bd\u03b9\u03b1 \u03bd\u03b5\u03c5\u03c1\u03ce\u03bc\u03b1\u03c4\u03b1, \u03b5\u03bd\u03c4\u03b5\u03c1\u03b9\u03ba\u03ac \u03b3\u03b1\u03b3\u03b3\u03bb\u03b9\u03bf\u03bd\u03b5\u03c5\u03c1\u03ce\u03bc\u03b1\u03c4\u03b1, \u03c3\u03ba\u03b5\u03bb\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b4\u03c5\u03c3\u03c0\u03bb\u03b1\u03c3\u03af\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03bc\u03b1\u03c1\u03c6\u03b1\u03bd\u03bf\u03b5\u03b9\u03b4\u03ae \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7.<br \/>\n<b><\/b><\/li>\n<li><b>\u03a4\u03b1 \u039f\u03b9\u03ba\u03bf\u03b3\u03b5\u03bd\u03ae \u039c\u039a\u0398<\/b> \u03c3\u03c4\u03b1 \u03bf\u03c0\u03bf\u03af\u03b1 \u03b7 \u03bc\u03cc\u03bd\u03b7 \u03b5\u03ba\u03b4\u03ae\u03bb\u03c9\u03c3\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf \u039c\u039a\u0398. \u03a4\u03b1 \u03bf\u03b9\u03ba\u03bf\u03b3\u03b5\u03bd\u03ae \u039c\u039a\u0398 \u03b8\u03b5\u03c9\u03c1\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c3\u03ae\u03bc\u03b5\u03c1\u03b1 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf \u03c6\u03b1\u03b9\u03bd\u03bf\u03c4\u03c5\u03c0\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b1\u03c1\u03b1\u03bb\u03bb\u03b1\u03b3\u03ad\u03c2 \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b4\u03c1\u03cc\u03bc\u03bf\u03c5 \u039c\u0395\u039d2\u0391 \u03bc\u03b5 \u03c7\u03b1\u03bc\u03b7\u03bb\u03ae \u03b4\u03b9\u03b5\u03b9\u03c3\u03b4\u03c5\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03bf\u03c5 \u03c6\u03b1\u03b9\u03bf\u03c7\u03c1\u03c9\u03bc\u03bf\u03ba\u03c5\u03c4\u03c4\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c0\u03b1\u03c1\u03ac \u03bc\u03b9\u03b1 \u03b4\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03ae \u03bf\u03bd\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1 (Kloos et al 2009).<\/li>\n<\/ul>\n<h4 style=\"text-align: justify;\"><b>3. \u039f\u03b3\u03ba\u03bf\u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf <\/b><b>RET<\/b><b><\/b><\/h4>\n<h5 style=\"text-align: justify;\"><b>3.1. \u0395\u03b9\u03c3\u03b1\u03b3\u03c9\u03b3\u03b9\u03ba\u03ac \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1<\/b><\/h5>\n<p style=\"text-align: justify;\">\u0397 \u03ba\u03bb\u03b7\u03c1\u03bf\u03bd\u03bf\u03bc\u03bf\u03cd\u03bc\u03b5\u03bd\u03b7 \u03bc\u03bf\u03c1\u03c6\u03ae \u03c4\u03bf\u03c5 \u039c\u039a\u0398 \u03c3\u03c5\u03bd\u03b4\u03ad\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03c3\u03c4\u03bf \u03c0\u03c1\u03c9\u03c4\u03bf-\u03bf\u03b3\u03ba\u03bf\u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf RET. \u03a4\u03bf RET \u03ba\u03c9\u03b4\u03b9\u03ba\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03bc\u03b9\u03b1 \u03b4\u03b9\u03b1\u03bc\u03b5\u03bc\u03b2\u03c1\u03b1\u03bd\u03b9\u03ba\u03ae \u03ba\u03b9\u03bd\u03ac\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c4\u03c5\u03c1\u03bf\u03c3\u03af\u03bd\u03b7\u03c2 (TK) \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03b5\u03bc\u03c0\u03bb\u03ad\u03ba\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 \u03ba\u03b1\u03b9 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b9\u03c3\u03c4\u03ce\u03bd \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ad\u03c1\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03bd\u03b5\u03c5\u03c1\u03b9\u03ba\u03ae \u03b1\u03ba\u03c1\u03bf\u03bb\u03bf\u03c6\u03af\u03b1 \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7\u03bd \u03b5\u03bc\u03b2\u03c1\u03c5\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7.<\/p>\n<p style=\"text-align: justify;\">\u03a4\u03bf \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf \u03b5\u03b4\u03c1\u03b5\u03cd\u03b5\u03b9 \u03c3\u03c4\u03bf \u03c7\u03c1\u03c9\u03bc\u03cc\u03c3\u03c9\u03bc\u03b1 10, \u03c0\u03b5\u03c1\u03b9\u03ad\u03c7\u03b5\u03b9 21 \u03b5\u03be\u03ce\u03bd\u03b9\u03b1 \u03c3\u03b5 \u03bc\u03b9\u03b1 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ae 60kb. \u0397 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 ret \u03ad\u03c7\u03b5\u03b9 \u03c4\u03c1\u03b5\u03af\u03c2 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ad\u03c2 \u03bc\u03af\u03b1 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b7 \u03b5\u03bd\u03b4\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03b9\u03bf \u03bc\u03b5 \u03b4\u03cd\u03bf \u03c5\u03c0\u03bf\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 TK \u03bc\u03af\u03b1 \u03b4\u03b9\u03b1\u03bc\u03b5\u03bc\u03b2\u03c1\u03b1\u03bd\u03b9\u03ba\u03ae \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ae \u03ba\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03b5\u03be\u03c9\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03b9\u03bf \u03bc\u03b5 \u03c4\u03ad\u03c3\u03c3\u03b5\u03c1\u03b5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ad\u03c2 \u03c4\u03cd\u03c0\u03bf\u03c5 \u03ba\u03b1\u03b4\u03b5\u03c1\u03af\u03bd\u03b7\u03c2\u00a0 (cadherin) \u03ba\u03b1\u03b9 \u03bc\u03af\u03b1 \u03c0\u03bb\u03bf\u03cd\u03c3\u03b9\u03b1 \u03c3\u03b5 \u03ba\u03c5\u03c3\u03c4\u03b5\u0390\u03bd\u03b5\u03c2 \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03b2\u03c1\u03af\u03c3\u03ba\u03b5\u03c4\u03b1\u03b9 \u03ba\u03bf\u03bd\u03c4\u03ac \u03c3\u03c4\u03b7 \u03bc\u03b5\u03bc\u03b2\u03c1\u03ac\u03bd\u03b7 (\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 1).<\/p>\n<p style=\"text-align: justify;\">\u03a4\u03bf \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf RET \u03c4\u03b1\u03c5\u03c4\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03c0\u03c1\u03ce\u03c4\u03b7 \u03c6\u03bf\u03c1\u03ac \u03c4\u03bf 1985. \u03a4\u03bf 1993 \u03c3\u03c5\u03bd\u03b4\u03ad\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03b9\u03c4\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03c4\u03bf\u03c5 \u03bc\u03b5 \u03c4\u03bf \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf \u039c\u0395\u039d 2\u0391 \u03b5\u03bd\u03ce \u03c4\u03bf 1994 \u03c3\u03c5\u03bd\u03b4\u03ad\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03bf \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf \u039c\u0395\u039d 2\u0392. \u03a4\u03bf \u03c0\u03c1\u03ce\u03c4\u03bf \u03b4\u03b9\u03b5\u03b8\u03bd\u03ad\u03c2 consortium \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 \u03c4\u03c9\u03bd \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03c9\u03bd \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03bf\u03c5 RET \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c4\u03bf 1996 \u03c3\u03c4\u03bf Gubbio \u0399\u03c4\u03b1\u03bb\u03af\u03b1\u03c2 (Eng et al 1996).<\/p>\n<hr style=\"width: 100%; border-width: 1px; border-style: solid; border-color: #CCCCCC; color: #ffffff;\" noshade=\"noshade\" width=\"100%\" \/>\n<p style=\"text-align: justify;\">\u00a0\u00a0\u00a0\u00a0 <img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-1203\" alt=\"3.11image1\" src=\"https:\/\/e-endocrinology.gr\/wp-content\/uploads\/2015\/02\/3.11image1.jpg\" width=\"500\" height=\"545\" srcset=\"https:\/\/e-endocrinology.gr\/wp-content\/uploads\/2015\/02\/3.11image1.jpg 500w, https:\/\/e-endocrinology.gr\/wp-content\/uploads\/2015\/02\/3.11image1-275x300.jpg 275w\" sizes=\"(max-width: 500px) 100vw, 500px\" \/><\/p>\n<p style=\"text-align: justify;\"><b>\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 1.\u00a0 <\/b>\u03a3\u03c7\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c0\u03b1\u03c1\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2 <i>RET<\/i> (De Groot <i>et<\/i><i> <\/i><i>al<\/i><i> <\/i>2006).<\/p>\n<hr style=\"width: 100%; border-width: 1px; border-style: solid; border-color: #CCCCCC; color: #ffffff;\" noshade=\"noshade\" width=\"100%\" \/>\n<h5 style=\"text-align: justify;\"><b>\u00a03.2. \u03a1\u03cc\u03bb\u03bf\u03c2 \u039f\u03b3\u03ba\u03bf\u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03bf\u03c5 <\/b><b>RET<\/b><b> <\/b><\/h5>\n<p style=\"text-align: justify;\">\u03a0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c2 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc\u03c2 \u03c4\u03bf\u03c5 \u03c1\u03cc\u03bb\u03bf\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03b4\u03b9\u03b1\u03b2\u03af\u03b2\u03b1\u03c3\u03b7 \u03bc\u03b7\u03bd\u03c5\u03bc\u03ac\u03c4\u03c9\u03bd \u03c3\u03b5 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03bd\u03b5\u03c5\u03c1\u03b9\u03ba\u03ae\u03c2 \u03c0\u03c1\u03bf\u03ad\u03bb\u03b5\u03c5\u03c3\u03b7\u03c2 \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7\u03bd \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7, \u03c1\u03c5\u03b8\u03bc\u03af\u03b6\u03b5\u03b9 \u03c4\u03bf\u03bd \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03cc, \u03c4\u03b7\u03bd \u03bc\u03b5\u03c4\u03b1\u03bd\u03ac\u03c3\u03c4\u03b5\u03c5\u03c3\u03b7, \u03c4\u03b7\u03bd \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7 \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2\u00a0 \u03b5\u03bc\u03b2\u03c1\u03c5\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7\u03c2.<\/p>\n<p style=\"text-align: justify;\">\u0388\u03c7\u03bf\u03c5\u03bd \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03b1\u03c6\u03b5\u03af \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03bf\u03c5 \u03b1\u03c5\u03c4\u03bf\u03cd \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c4\u03bf\u03c5 \u03cc\u03b3\u03ba\u03bf\u03c5 (\u03c3\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2) \u03c3\u03b5 \u03c3\u03c0\u03bf\u03c1\u03b1\u03b4\u03b9\u03ba\u03ac \u03bc\u03c5\u03b5\u03bb\u03bf\u03b5\u03b9\u03b4\u03ae \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03ce\u03bc\u03b1\u03c4\u03b1 \u03b5\u03bd\u03ce \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03bc\u03b5\u03c4\u03ad\u03c7\u03b5\u03b9 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03c0\u03b1\u03b8\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1 \u03c4\u03bf\u03c5 \u03b8\u03b7\u03bb\u03ce\u03b4\u03bf\u03c5\u03c2 \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03bf\u03cd\u03c2 \u03c3\u03c4\u03bf \u03bf\u03c0\u03bf\u03af\u03bf \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03c3\u03c5\u03c7\u03bd\u03ac \u03c7\u03c1\u03c9\u03bc\u03bf\u03c3\u03c9\u03bc\u03b9\u03ba\u03ad\u03c2 \u03b1\u03bd\u03b1\u03b4\u03b9\u03b1\u03c4\u03ac\u03be\u03b5\u03b9\u03c2 \u03c3\u03c4\u03b9\u03c2 \u03bf\u03c0\u03bf\u03af\u03b5\u03c2 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03ad\u03c7\u03b5\u03b9\u00a0 \u03c4\u03bf \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf RET (RET\/PTC).<\/p>\n<h5 style=\"text-align: justify;\"><b>3.3. \u0397 \u03bc\u03b5\u03c4\u03b1\u03b2\u03af\u03b2\u03b1\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5 \u03c3\u03c4\u03b1 \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03b1 \u039c\u0395\u039d2<\/b><\/h5>\n<p style=\"text-align: justify;\">\u03a3\u03c4\u03b9\u03c2 \u03bf\u03b9\u03ba\u03bf\u03b3\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c4\u03bf\u03c5 \u039c\u039a\u0398 \u03b7 \u03bc\u03b5\u03c4\u03b1\u03b2\u03af\u03b2\u03b1\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03b5\u03c0\u03b9\u03ba\u03c1\u03b1\u03c4\u03bf\u03cd\u03bd\u03c4\u03b1 \u03b1\u03c5\u03c4\u03bf\u03c3\u03c9\u03bc\u03b9\u03ba\u03cc \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03ae\u03c1\u03b1 (\u03ba\u03ac\u03b8\u03b5 \u03b1\u03c0\u03cc\u03b3\u03bf\u03bd\u03bf\u03c2 \u03ad\u03c7\u03b5\u03b9 50% \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03bd\u03b1 \u03bd\u03bf\u03c3\u03ae\u03c3\u03b5\u03b9) \u03ba\u03b1\u03b9 \u03b7 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b1\u03c1\u03bf\u03cd\u03c3\u03b1 \u03c3\u03b5 \u03cc\u03bb\u03b1 \u03c4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c4\u03bf\u03c5 \u03bf\u03c1\u03b3\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03cd \u03c3\u03b5 \u03b5\u03c4\u03b5\u03c1\u03cc\u03b6\u03c5\u03b3\u03b7 \u03bc\u03bf\u03c1\u03c6\u03ae \u03c3\u03c4\u03bf \u03c3\u03cd\u03bd\u03bf\u03bb\u03bf \u03c3\u03c7\u03b5\u03b4\u03cc\u03bd \u03c4\u03c9\u03bd \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03c9\u03bd. \u0397 \u03ba\u03ac\u03b8\u03b5 \u03bf\u03b9\u03ba\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1 \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03bc\u03b9\u03b1 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b7 \u03b3\u03b9 \u03b1\u03c5\u03c4\u03ae\u03bd \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7. \u0388\u03c7\u03bf\u03c5\u03bd \u03b5\u03bd\u03c4\u03bf\u03c0\u03b9\u03c3\u03c4\u03b5\u03af \u03ba\u03b1\u03b9 \u03b1\u03c1\u03ba\u03b5\u03c4\u03bf\u03af \u03c0\u03bf\u03bb\u03c5\u03bc\u03bf\u03c1\u03c6\u03b9\u03c3\u03bc\u03bf\u03af \u03c4\u03bf\u03c5 RET \u03c0\u03bf\u03c5 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c3\u03c5\u03bd\u03b4\u03b5\u03b8\u03b5\u03af \u03bc\u03b5 \u03c4\u03b7\u03bd \u03c0\u03bf\u03c1\u03b5\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03b8\u03b5\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5.<\/p>\n<h5 style=\"text-align: justify;\"><b>3.4. \u039c\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03bf\u03c5 <\/b><b>RET<\/b><b><\/b><\/h5>\n<p style=\"text-align: justify;\">\u03a4\u03bf 1993 \u03b3\u03b9\u03b1 \u03c0\u03c1\u03ce\u03c4\u03b7 \u03c6\u03bf\u03c1\u03ac \u03b4\u03cd\u03bf \u03b1\u03bd\u03b5\u03be\u03ac\u03c1\u03c4\u03b7\u03c4\u03b5\u03c2 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03b1\u03bd\u03b1\u03ba\u03ac\u03bb\u03c5\u03c8\u03b1\u03bd \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03bf\u03c5 RET \u03c3\u03c4\u03b7 \u03b3\u03b1\u03bc\u03b5\u03c4\u03b9\u03ba\u03ae \u03c3\u03b5\u03b9\u03c1\u03ac \u03bf\u03b9 \u03bf\u03c0\u03bf\u03af\u03b5\u03c2 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b1\u03b9\u03c4\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03c3\u03c7\u03ad\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03bf \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf \u039c\u0395\u039d2\u0391 (Mulligan et al 1993) \u03ba\u03b1\u03b9 \u03c4\u03bf \u03bf\u03b9\u03ba\u03bf\u03b3\u03b5\u03bd\u03ad\u03c2 \u039c\u039a\u0398 (Donis-Keller et al 1993). \u0388\u03bd\u03b1 \u03c7\u03c1\u03cc\u03bd\u03bf \u03b1\u03c1\u03b3\u03cc\u03c4\u03b5\u03c1\u03b1 \u03c4\u03bf\u00a0 \u039c\u0395\u039d2\u0392 \u03c3\u03c5\u03bd\u03b4\u03ad\u03b8\u03b7\u03ba\u03b5 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03bc\u03b5 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03bf\u03c5 RET (Eng et al 1994, Carlson et al 1994, Hofstra et al 1994).<\/p>\n<p style=\"text-align: justify;\">\u03a3\u03c4\u03bf \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf <b>\u039c\u0395\u039d 2\u0391<\/b> \u03b7 \u03c0\u03bb\u03b5\u03b9\u03bf\u03c8\u03b7\u03c6\u03af\u03b1 \u03c4\u03c9\u03bd \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03c9\u03bd \u03b5\u03bd\u03c4\u03bf\u03c0\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03c0\u03bb\u03bf\u03cd\u03c3\u03b9\u03b1 \u03c3\u03b5 \u03ba\u03c5\u03c3\u03c4\u03b5\u0390\u03bd\u03b5\u03c2 \u03b5\u03be\u03c9\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03b9\u03b1 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ae (\u03c3\u03c4\u03b1 \u03ba\u03c9\u03b4\u03b9\u03ba\u03cc\u03bd\u03b9\u03b1 609, 611, 618, 620 \u03c4\u03bf\u03c5 \u03b5\u03be\u03c9\u03bd\u03af\u03bf\u03c5 10 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03bf \u03ba\u03c9\u03b4\u03b9\u03ba\u03cc\u03bd\u03b9\u03bf 634 \u03c4\u03bf\u03c5 \u03b5\u03be\u03c9\u03bd\u03af\u03bf\u03c5 11). \u0395\u03af\u03bd\u03b1\u03b9 \u03b5\u03bd\u03b4\u03b9\u03b1\u03c6\u03ad\u03c1\u03bf\u03bd \u03cc\u03c4\u03b9\u00a0 \u03c4\u03bf <b>85% <\/b>\u03c4\u03c9\u03bd \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03c9\u03bd \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf \u03b5\u03be\u03ce\u03bd\u03b9\u03bf 11 \u03c3\u03c4\u03bf \u03ba\u03c9\u03b4\u03b9\u03ba\u03cc\u03bd\u03b9\u03bf <b>634 <\/b>\u03c0\u03bf\u03c5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03b7 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b5\u03c1\u03b7 \u03b8\u03ad\u03c3\u03b7 (Elisei 2008).<\/p>\n<p style=\"text-align: justify;\">\u03a3\u03c4\u03bf \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf <b>\u039c\u0395\u039d 2\u0392<\/b> \u03c4\u03bf 95% \u03c4\u03c9\u03bd \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03c9\u03bd \u03c3\u03c5\u03bd\u03b4\u03ad\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03bc\u03af\u03b1 \u03c3\u03b7\u03bc\u03b5\u03b9\u03b1\u03ba\u03ae \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 \u03c3\u03c4\u03bf \u03ba\u03c9\u03b4\u03b9\u03ba\u03cc\u03bd\u03b9\u03bf\u00a0 918 \u03c4\u03bf\u03c5 \u03b5\u03be\u03c9\u03bd\u03af\u03bf\u03c5 16.<\/p>\n<p style=\"text-align: justify;\">\u039c\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b5\u03c5\u03c1\u03b5\u03af\u03b1 \u03b5\u03c6\u03b1\u03c1\u03bc\u03bf\u03b3\u03ae \u03c4\u03b7\u03c2 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03bf\u03c5 RET \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u039c\u0395\u039d2 \u03ba\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03ac\u03bb\u03bb\u03b7\u03bb\u03b7 \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 \u03c4\u03b7\u03c2 \u03c4\u03b5\u03c7\u03bd\u03bf\u03bb\u03bf\u03b3\u03af\u03b1\u03c2 \u03ad\u03c7\u03b5\u03b9 \u03b3\u03af\u03bd\u03b5\u03b9 \u03b4\u03c5\u03bd\u03b1\u03c4\u03ae \u03b7 \u03b5\u03c5\u03c1\u03b5\u03af\u03b1 \u03ba\u03b1\u03b9 \u03b3\u03c1\u03ae\u03b3\u03bf\u03c1\u03b7 \u03b1\u03bd\u03af\u03c7\u03bd\u03b5\u03c5\u03c3\u03b7 \u03c4\u03c9\u03bd \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03c9\u03bd RET (\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 2). \u03a0\u03c1\u03cc\u03c3\u03c6\u03b1\u03c4\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b2\u03c1\u03b5\u03b8\u03b5\u03af \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b1 \u03b5\u03be\u03ce\u03bd\u03b9\u03b1 5, 8, 13, 14 \u03ba\u03b1\u03b9 15. \u0388\u03c4\u03c3\u03b9 \u03b1\u03c5\u03be\u03ae\u03b8\u03b7\u03ba\u03b1\u03bd \u03ba\u03b1\u03b9 \u03b1\u03c5\u03be\u03ac\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c5\u03bd\u03b5\u03c7\u03ce\u03c2 \u03c4\u03cc\u03c3\u03bf \u03bf \u03b1\u03c1\u03b9\u03b8\u03bc\u03cc\u03c2 \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03bf\u03b9 \u03c4\u03cd\u03c0\u03bf\u03b9 \u03bd\u03ad\u03c9\u03bd \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03c9\u03bd \u03c0\u03bf\u03c5 \u03b5\u03c5\u03b8\u03cd\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03cc\u03b3\u03ba\u03bf\u03c5\u03c2 \u039c\u039a\u0398.<\/p>\n<p style=\"text-align: justify;\">\u03a5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b7 \u03c0\u03bf\u03b9\u03ba\u03b9\u03bb\u03af\u03b1 \u03b4\u03b9\u03b5\u03b8\u03bd\u03ce\u03c2 \u03c4\u03cc\u03c3\u03bf \u03c3\u03c4\u03bf \u03c0\u03c1\u03bf\u03c6\u03af\u03bb \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03ba\u03b1\u03c4\u03b1\u03bd\u03bf\u03bc\u03ae \u03c4\u03c9\u03bd \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03c9\u03bd \u03b1\u03c0\u03cc \u03c7\u03ce\u03c1\u03b1 \u03c3\u03b5 \u03c7\u03ce\u03c1\u03b1.<\/p>\n<hr style=\"width: 100%; border-width: 1px; border-style: solid; border-color: #CCCCCC; color: #ffffff;\" noshade=\"noshade\" width=\"100\" \/>\n<p style=\"text-align: justify;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-1204\" alt=\"3.11image2\" src=\"https:\/\/e-endocrinology.gr\/wp-content\/uploads\/2015\/02\/3.11image2.jpg\" width=\"550\" height=\"419\" srcset=\"https:\/\/e-endocrinology.gr\/wp-content\/uploads\/2015\/02\/3.11image2.jpg 550w, https:\/\/e-endocrinology.gr\/wp-content\/uploads\/2015\/02\/3.11image2-300x228.jpg 300w\" sizes=\"(max-width: 550px) 100vw, 550px\" \/><\/p>\n<p style=\"text-align: justify;\"><b>\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 2. <\/b>\u03a3\u03c7\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c0\u03b1\u03c1\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03bf\u03c5 ret (21 \u03b5\u03be\u03ce\u03bd\u03b9\u03b1) \u03ba\u03b1\u03b9 \u03c4\u03c9\u03bd \u03b8\u03ad\u03c3\u03b5\u03c9\u03bd \u03c3\u03c4\u03b9\u03c2 \u03bf\u03c0\u03bf\u03af\u03b5\u03c2 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03b1\u03c6\u03b5\u03af \u03bf\u03b9 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03c3\u03c4\u03b1 \u03bf\u03b9\u03ba\u03bf\u03b3\u03b5\u03bd\u03ae \u039c\u039a\u0398 (FMTC, MEN2A, MEN2B) \u03ba\u03b1\u03b9 \u03c3\u03c4\u03bf \u03c3\u03c5\u03b3\u03b3\u03b5\u03bd\u03ad\u03c2 \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf\u00a0 Hirschprung (HSCR).\u00a0 CL\u0391: Cutaneous Lichen Amyloidosis (De Groot <i>et<\/i><i> <\/i><i>al<\/i><i>. <\/i>2006<i>)<\/i>.<\/p>\n<hr style=\"width: 100%; border-width: 1px; border-style: solid; border-color: #CCCCCC; color: #ffffff;\" noshade=\"noshade\" width=\"100%\" \/>\n<p style=\"text-align: justify;\">\u03a3\u03c4\u03b7 \u03c7\u03ce\u03c1\u03b1 \u03bc\u03b1\u03c2 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03ad\u03c7\u03c1\u03b9 \u03c3\u03ae\u03bc\u03b5\u03c1\u03b1 \u03bf\u03b9 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03c0\u03bf\u03c5 \u03b1\u03c0\u03b5\u03b9\u03ba\u03bf\u03bd\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf\u03bd \u03a0\u03af\u03bd\u03b1\u03ba\u03b1 1. \u03a4\u03b1 \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1 \u03b1\u03c5\u03c4\u03ac \u03b5\u03af\u03bd\u03b1\u03b9 \u03c5\u03c0\u03cc \u03b4\u03b7\u03bc\u03bf\u03c3\u03af\u03b5\u03c5\u03c3\u03b7 \u03b1\u03c0\u03cc \u03c4\u03bf \u03ba\u03ad\u03bd\u03c4\u03c1\u03bf \u03b1\u03bd\u03b1\u03c6\u03bf\u03c1\u03ac\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b1 \u039c\u0395\u039d2 \u03c4\u03b7\u03c2 \u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae\u03c2 \u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03c4\u03bf\u03c5 \u03a0\u03b1\u03bd. \u0391\u03b8\u03b7\u03bd\u03ce\u03bd \u03ba\u03b1\u03b9 \u03c4\u03bf\u03c5 1<sup>\u03bf\u03c5<\/sup> \u0395\u03bd\u03b4\u03bf\u03ba\u03c1\u03b9\u03bd\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03bf\u03cd \u03a4\u03bc. \u03c4\u03bf\u03c5 \u039d\u03bf\u03c3. \u00ab\u0391\u039b\u0395\u039e\u0391\u039d\u0394\u03a1\u0391\u00bb.<\/p>\n<p style=\"text-align: justify;\">\u0395\u03af\u03bd\u03b1\u03b9 \u03b5\u03bd\u03b4\u03b9\u03b1\u03c6\u03ad\u03c1\u03bf\u03bd \u03cc\u03c4\u03b9 \u03c4\u03bf \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03bf \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03c4\u03c9\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03b4\u03b7\u03bb\u03b1\u03b4\u03ae \u03ad\u03bd\u03b1 36,21% \u03c6\u03ad\u03c1\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 TGG\/TGC \u03c3\u03c4\u03bf \u03ba\u03c9\u03b4\u03b9\u03ba\u03cc\u03bd\u03b9\u03bf 533 \u03c4\u03bf\u03c5 \u03b5\u03be\u03c9\u03bd\u03af\u03bf\u03c5 8 \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03bf\u03bb\u03cd \u03c3\u03c0\u03ac\u03bd\u03b9\u03b1 \u03c3\u03b5 \u03ac\u03bb\u03bb\u03b5\u03c2 \u03c7\u03ce\u03c1\u03b5\u03c2 \u03cc\u03c0\u03c9\u03c2 \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b4\u03b9\u03b5\u03b8\u03bd\u03ae \u03b2\u03b9\u03b2\u03bb\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1 (Sarika et al 2012).<\/p>\n<p style=\"text-align: justify;\"><b>\u00a0\u00a0 \u0395\u039e\u03a9\u039d\u0399\u039f \u00a0\u039a\u03a9\u0394\u0399\u039a\u039f\u039d\u0399\u039f\u00a0\u00a0 \u039c\u0395\u03a4\u0391\u039b\u039b\u0391\u039e\u0397\u00a0 \u00a0\u00a0\u03a0\u039f\u03a3\u039f\u03a3\u03a4\u039f\u00a0 <\/b><\/p>\n<p style=\"text-align: justify;\"><b>\u00a0\u00a0\u00a0 8\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<\/b>533\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0TGG\/TGC\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0\u00a0\u00a0\u00a036, 21 %<\/p>\n<p style=\"text-align: justify;\"><b>\u00a0\u00a0 <\/b><b>10<\/b>\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0\u00a0\u00a0618\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0TGC\/CGC\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a03, 45 %<b>\u00a0 <\/b><\/p>\n<p style=\"text-align: justify;\"><b>\u00a0\u00a0 10\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0\u00a0\u00a0\u00a0<\/b>618\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0TGC\/TAC\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 1, 72 %<\/p>\n<p style=\"text-align: justify;\">\u00a0 <b>\u00a010<\/b>\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0\u00a0\u00a0\u00a0618\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0TGC\/TCC\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a01, 72 %<\/p>\n<p style=\"text-align: justify;\"><b>\u00a0\u00a0 10\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<\/b>620\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0TGC\/TAC\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a01, 72 %<\/p>\n<p style=\"text-align: justify;\"><b>\u00a0\u00a0 10<\/b>\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0620\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0TGC\/CGC\u00a0\u00a0\u00a0\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a05, 18 %<\/p>\n<p style=\"text-align: justify;\"><b>\u00a0\u00a0 10\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<\/b>620\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0TGC\/TTC\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 1, 72 %<\/p>\n<p style=\"text-align: justify;\">\u00a0\u00a0 <b>11<\/b>\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0634\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0TGC\/CGC\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0\u00a018, 97 %<\/p>\n<p style=\"text-align: justify;\"><b>\u00a0\u00a0 11\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<\/b>634\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0TGC\/TAC\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a012, 07 %<\/p>\n<p style=\"text-align: justify;\"><b>\u00a0\u00a0 11\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<\/b>634\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0TGC\/TTC\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a01, 72 %<\/p>\n<p style=\"text-align: justify;\"><b>\u00a0\u00a0 13\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<\/b>768\u00a0\u00a0\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0GAG\/GAC\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a01, 72 %<\/p>\n<p style=\"text-align: justify;\">\u00a0\u00a0 <b>14<\/b>\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0804\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0GTG\/ATG\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0\u00a05, 18 %<\/p>\n<p style=\"text-align: justify;\"><b>\u00a0\u00a0 16<\/b>\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0\u00a0\u00a0\u00a0918\u00a0\u00a0\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0AGC\/ATG\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a08, 62 %<\/p>\n<p style=\"text-align: justify;\"><b>\u03a0\u03af\u03bd\u03b1\u03ba\u03b1\u03c2 1. <\/b>\u039a\u03b1\u03c4\u03b1\u03bd\u03bf\u03bc\u03ae \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03c9\u03bd RET \u03c3\u03c4\u03b1 \u03bf\u03b9\u03ba\u03bf\u03b3\u03b5\u03bd\u03ae \u039c\u039a\u0398 \u03c3\u03b5 \u03ad\u03bd\u03b1 \u03ba\u03ad\u03bd\u03c4\u03c1\u03bf \u03b1\u03bd\u03b1\u03c6\u03bf\u03c1\u03ac\u03c2 \u03c3\u03c4\u03b7\u03bd \u0395\u03bb\u03bb\u03ac\u03b4\u03b1.<\/p>\n<h4 style=\"text-align: justify;\"><b>4. \u03a3\u03c7\u03ad\u03c3\u03b7\u00a0 \u0393\u03bf\u03bd\u03bf\u03c4\u03cd\u03c0\u03bf\u03c5\u00a0 \u03a6\u03b1\u03b9\u03bd\u03cc\u03c4\u03c5\u03c0\u03bf\u03c5<\/b><\/h4>\n<p style=\"text-align: justify;\">\u039c\u03b5\u03bb\u03ad\u03c4\u03b7 \u03bc\u03b5\u03b3\u03ac\u03bb\u03c9\u03bd \u03c3\u03b5\u03b9\u03c1\u03ce\u03bd \u03ba\u03bb\u03b7\u03c1\u03bf\u03bd\u03bf\u03bc\u03bf\u03cd\u03bc\u03b5\u03bd\u03c9\u03bd \u039c\u039a\u0398 \u03ad\u03b4\u03b5\u03b9\u03be\u03b5 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03c3\u03c7\u03ad\u03c4\u03b9\u03c3\u03b7 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03c9\u03bd \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03c9\u03bd\u00a0 RET \u03c4\u03cc\u03c3\u03bf \u03bc\u03b5 \u03c4\u03bf \u03c6\u03b1\u03b9\u03bd\u03cc\u03c4\u03c5\u03c0\u03bf \u03b4\u03b7\u03bb\u03b1\u03b4\u03ae \u03c4\u03b1 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5 (MEN2A, MEN2B,FMTC) \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03b8\u03b5\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03bf\u03c5 \u039c\u039a\u0398. \u03a3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b1 \u03b7 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 \u039c918\u03a4 \u03c0\u03bf\u03c5 \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03af\u03b6\u03b5\u03b9 \u03c4\u03bf \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf \u039c\u0395\u039d2\u0392 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03c0\u03b9\u03bf \u03b5\u03c0\u03b9\u03b8\u03b5\u03c4\u03b9\u03ba\u03ae \u03ba\u03b1\u03b9 \u03b7 \u03c0\u03bb\u03b5\u03b9\u03bf\u03c8\u03b7\u03c6\u03af\u03b1 \u03c4\u03c9\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03bc\u03b5 \u03b1\u03c5\u03c4\u03ae\u03bd \u03c4\u03b7\u03bd \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03b9\u03ac\u03b6\u03bf\u03c5\u03bd \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03b8\u03bd\u03b7\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c3\u03b5 \u03bd\u03ad\u03b1 \u03b7\u03bb\u03b9\u03ba\u03af\u03b1. \u0391\u03bd\u03c4\u03af\u03b8\u03b5\u03c4\u03b1 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03bf\u03c5 \u03c6\u03ad\u03c1\u03bf\u03c5\u03bd \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03cc\u03c0\u03c9\u03c2 Y791F \u03ba\u03b1\u03b9 A883T \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03bd \u03bd\u03b1 \u03bc\u03b7\u03bd \u03b1\u03bd\u03b1\u03c0\u03c4\u03cd\u03be\u03bf\u03c5\u03bd \u03c0\u03bf\u03c4\u03ad \u039c\u039a\u0398 \u03c3\u03c4\u03b7\u03bd \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 \u03b6\u03c9\u03ae\u03c2 \u03c4\u03bf\u03c5\u03c2 (Elisei et al 2008).<\/p>\n<p style=\"text-align: justify;\">\u03a4\u03bf \u03b5\u03af\u03b4\u03bf\u03c2 \u03c4\u03b7\u03c2 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7\u03c2 \u03c3\u03c5\u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c4\u03cc\u03c3\u03bf \u03bc\u03b5 \u03c4\u03b7 \u03b7\u03bb\u03b9\u03ba\u03af\u03b1 \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7\u03c2 \u03c4\u03bf\u03c5 \u039c\u039a\u0398 \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b4\u03b9\u03b1\u03b2\u03ac\u03b8\u03bc\u03b9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b5\u03c0\u03b9\u03ba\u03b9\u03bd\u03b4\u03c5\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5 (risk levels) \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03ba\u03b1\u03c4\u03b5\u03c5\u03b8\u03cd\u03bd\u03b5\u03b9 \u03ba\u03b1\u03b9 \u03c4\u03bf\u03bd \u03c7\u03b5\u03b9\u03c1\u03b9\u03c3\u03bc\u03cc \u03c4\u03b7\u03c2 (Kouvaraki et al 2005) (\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 3).<\/p>\n<hr style=\"width: 100%; border-width: 1px; border-style: solid; border-color: #CCCCCC; color: #ffffff;\" noshade=\"noshade\" width=\"100%\" \/>\n<p style=\"text-align: justify;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-1205\" alt=\"3.11image3\" src=\"https:\/\/e-endocrinology.gr\/wp-content\/uploads\/2015\/02\/3.11image3.jpg\" width=\"600\" height=\"810\" srcset=\"https:\/\/e-endocrinology.gr\/wp-content\/uploads\/2015\/02\/3.11image3.jpg 600w, https:\/\/e-endocrinology.gr\/wp-content\/uploads\/2015\/02\/3.11image3-222x300.jpg 222w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p style=\"text-align: justify;\"><b>\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 3.<\/b> \u039f\u03bc\u03ac\u03b4\u03b5\u03c2 \u03b5\u03c0\u03b9\u03ba\u03b9\u03bd\u03b4\u03c5\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03bf\u03c5 RET \u03c3\u03b5 \u03bf\u03b9\u03ba\u03bf\u03b3\u03b5\u03bd\u03ae \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03b1\u00a0 \u039c\u039a\u0398 (Kouvaraki <i>et<\/i><i> <\/i><i>al<\/i> 2005)<\/p>\n<hr style=\"width: 100%; border-width: 1px; border-style: solid; border-color: #CCCCCC; color: #ffffff;\" noshade=\"noshade\" width=\"100%\" \/>\n<p style=\"text-align: justify;\">\u0397 \u0391\u03bc\u03b5\u03c1\u03b9\u03ba\u03b1\u03bd\u03b9\u03ba\u03ae \u0398\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae \u0395\u03c4\u03b1\u03b9\u03c1\u03b5\u03af\u03b1 (\u0391\u03a4\u0391) \u03ad\u03c7\u03b5\u03b9 \u03ba\u03b1\u03c4\u03b1\u03c4\u03ac\u03be\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b2\u03b1\u03c1\u03cd\u03c4\u03b7\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5 \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03b5\u03c0\u03b9\u03ba\u03b9\u03bd\u03b4\u03c5\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03c4\u03b5\u03af\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03ba\u03b1\u03c4\u03ac\u03bb\u03bb\u03b7\u03bb\u03b7 \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03ce\u03c0\u03b9\u03c3\u03b7 \u03a0\u03af\u03bd\u03b1\u03ba\u03b1\u03c2 2.<\/p>\n<p style=\"text-align: justify;\"><b>\u03a0\u03af\u03bd\u03b1\u03ba\u03b1\u03c2 2.\u00a0 <\/b>\u0395\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03b5\u03c0\u03b9\u03ba\u03b9\u03bd\u03b4\u03c5\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bd\u03b9\u03c3\u03c4\u03ce\u03bc\u03b5\u03bd\u03b7 \u03b7\u03bb\u03b9\u03ba\u03af\u03b1 \u03b3\u03b9\u03b1 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03c6\u03c5\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ae \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b5\u03ba\u03c4\u03bf\u03bc\u03ae \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u0391\u03bc\u03b5\u03c1\u03b9\u03ba\u03b1\u03bd\u03b9\u03ba\u03ae \u0398\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae \u0395\u03c4\u03b1\u03b9\u03c1\u03b5\u03af\u03b1 (\u0391\u03a4\u0391).<\/p>\n<table style=\"width: 100%;\" border=\"0\" cellspacing=\"3\" cellpadding=\"3\">\n<tbody>\n<tr style=\"background-color: #385a72;\">\n<td valign=\"top\" width=\"73\">\n<p align=\"center\"><span style=\"color: #ffffff;\"><strong>\u0395\u03c0\u03af\u03c0\u03b5\u03b4\u03bf \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5<\/strong><\/span><\/p>\n<\/td>\n<td valign=\"top\" width=\"132\">\n<p align=\"center\"><span style=\"color: #ffffff;\"><strong>\u0397\u03bb\u03b9\u03ba\u03af\u03b1 \u03b3\u03b9\u03b1 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf RET<\/strong><\/span><\/p>\n<\/td>\n<td valign=\"top\" width=\"123\">\n<p align=\"center\"><span style=\"color: #ffffff;\"><strong>\u0397\u03bb\u03b9\u03ba\u03af\u03b1 \u03c0\u03c1\u03ce\u03c4\u03bf\u03c5 \u03c5\u03c0\u03ad\u03c1\u03b7\u03c7\u03bf\u03c5<\/strong><\/span><\/p>\n<\/td>\n<td valign=\"top\" width=\"132\">\n<p align=\"center\"><span style=\"color: #ffffff;\"><strong>\u0397\u03bb\u03b9\u03ba\u03af\u03b1 \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5 \u03c0\u03c1\u03ce\u03c4\u03b7\u03c2 \u03ba\u03b1\u03bb\u03c3\u03b9\u03c4\u03bf\u03bd\u03af\u03bd\u03b7\u03c2<\/strong><\/span><\/p>\n<\/td>\n<td valign=\"top\" width=\"132\">\n<p align=\"center\"><span style=\"color: #ffffff;\"><strong>\u0397\u03bb\u03b9\u03ba\u03af\u03b1 \u03c0\u03c1\u03bf\u03c6\u03c5\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b5\u03ba\u03c4\u03bf\u03bc\u03ae\u03c2<\/strong><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td valign=\"top\" width=\"73\">\n<p align=\"center\">\u0394<\/p>\n<\/td>\n<td valign=\"top\" width=\"132\">\n<p align=\"center\">\u03a4\u03bf \u03c3\u03c5\u03bd\u03c4\u03bf\u03bc\u03cc\u03c4\u03b5\u03c1\u03bf \u03c3\u03c4\u03bf 1<sup>\u03bf<\/sup> \u03ad\u03c4\u03bf\u03c2 \u03b6\u03c9\u03ae\u03c2<\/p>\n<\/td>\n<td valign=\"top\" width=\"123\">\n<p align=\"center\">\u03a4\u03bf \u03c3\u03c5\u03bd\u03c4\u03bf\u03bc\u03cc\u03c4\u03b5\u03c1\u03bf \u03c3\u03c4\u03bf 1<sup>\u03bf<\/sup> \u03ad\u03c4\u03bf\u03c2 \u03b6\u03c9\u03ae\u03c2<\/p>\n<\/td>\n<td valign=\"top\" width=\"132\">\n<p align=\"center\">\u03a3\u03c4\u03bf\u03bd 6<sup>\u03bf<\/sup> \u03bc\u03ae\u03bd\u03b1 \u03b5\u03ac\u03bd \u03b4\u03b5\u03bd \u03ad\u03c7\u03b5\u03b9 \u03c0\u03c1\u03bf\u03b7\u03b3\u03b7\u03b8\u03b5\u03af \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b5\u03ba\u03c4\u03bf\u03bc\u03ae<\/p>\n<\/td>\n<td valign=\"top\" width=\"132\">\n<p align=\"center\">\u03a4\u03bf \u03c3\u03c5\u03bd\u03c4\u03bf\u03bc\u03cc\u03c4\u03b5\u03c1\u03bf \u03c3\u03c4\u03bf 1<sup>\u03bf<\/sup> \u03ad\u03c4\u03bf\u03c2 \u03b6\u03c9\u03ae\u03c2<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td valign=\"top\" width=\"73\">\n<p align=\"center\">\u0393<\/p>\n<\/td>\n<td valign=\"top\" width=\"132\">\n<p align=\"center\">&lt;3-5 \u03ad\u03c4\u03b7<\/p>\n<\/td>\n<td valign=\"top\" width=\"123\">\n<p align=\"center\">&lt;3-5 \u03ad\u03c4\u03b7<\/p>\n<\/td>\n<td valign=\"top\" width=\"132\">\n<p align=\"center\">&lt;3-5 \u03ad\u03c4\u03b7<\/p>\n<\/td>\n<td valign=\"top\" width=\"132\">\n<p align=\"center\">\u03a0\u03c1\u03b9\u03bd \u03c4\u03bf 5<sup>\u03bf<\/sup> \u03ad\u03c4\u03bf\u03c2<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td valign=\"top\" width=\"73\">\n<p align=\"center\">\u0392<\/p>\n<\/td>\n<td valign=\"top\" width=\"132\">\n<p align=\"center\">&lt;3-5 \u03ad\u03c4\u03b7<\/p>\n<\/td>\n<td valign=\"top\" width=\"123\">\n<p align=\"center\">&lt;3-5 \u03ad\u03c4\u03b7<\/p>\n<\/td>\n<td valign=\"top\" width=\"132\">\n<p align=\"center\">&lt;3-5 \u03ad\u03c4\u03b7<\/p>\n<\/td>\n<td valign=\"top\" width=\"132\">\n<p align=\"center\">\u039c\u03c0\u03bf\u03c1\u03b5\u03af \u03ba\u03b1\u03b9 \u03bc\u03b5\u03c4\u03ac \u03c4\u03bf 5<sup>\u03bf<\/sup> \u03ad\u03c4\u03bf\u03c2 \u03bc\u03b5 \u03b1\u03c5\u03c3\u03c4\u03b7\u03c1\u03ac \u03ba\u03c1\u03b9\u03c4\u03ae\u03c1\u03b9\u03b1<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td valign=\"top\" width=\"73\">\n<p align=\"center\">\u0391<\/p>\n<\/td>\n<td valign=\"top\" width=\"132\">\n<p align=\"center\">&lt;3-5 \u03ad\u03c4\u03b7<\/p>\n<\/td>\n<td valign=\"top\" width=\"123\">\n<p align=\"center\">&lt;3-5 \u03ad\u03c4\u03b7<\/p>\n<\/td>\n<td valign=\"top\" width=\"132\">\n<p align=\"center\">&lt;3-5 \u03ad\u03c4\u03b7<\/p>\n<\/td>\n<td valign=\"top\" width=\"132\">\n<p align=\"center\">\u039c\u03c0\u03bf\u03c1\u03b5\u03af \u03ba\u03b1\u03b9 \u03bc\u03b5\u03c4\u03ac \u03c4\u03bf 5<sup>\u03bf<\/sup> \u03ad\u03c4\u03bf\u03c2 \u03bc\u03b5 \u03b1\u03c5\u03c3\u03c4\u03b7\u03c1\u03ac \u03ba\u03c1\u03b9\u03c4\u03ae\u03c1\u03b9\u03b1<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h4 style=\"text-align: justify;\"><b>5. \u039c\u03bf\u03c1\u03b9\u03b1\u03ba\u03ad\u03c2 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf\u03b9 \u03b3\u03b9\u03b1 \u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 \u039c\u039a\u0398<\/b><\/h4>\n<p style=\"text-align: justify;\">\u0388\u03c7\u03bf\u03c5\u03bd \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03b5\u03af \u03c0\u03bf\u03bb\u03bb\u03ad\u03c2 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf\u03b9 \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03ae\u03c2 \u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf 1993 \u03c0\u03bf\u03c5 \u03be\u03b5\u03ba\u03af\u03bd\u03b7\u03c3\u03b5 \u03bf \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u039c\u039a\u0398.<\/p>\n<p style=\"text-align: justify;\">\u03a3\u03ae\u03bc\u03b5\u03c1\u03b1 \u03c4\u03b1 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b1 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae\u03c1\u03b9\u03b1 \u03b5\u03c6\u03b1\u03c1\u03bc\u03cc\u03b6\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03ac\u03bc\u03b5\u03c3\u03b7 \u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 \u03b1\u03bb\u03bb\u03b7\u03bb\u03bf\u03c5\u03c7\u03af\u03b1\u03c2 \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03bf\u03c5 (direct sequencing) \u03be\u03b5\u03ba\u03b9\u03bd\u03ce\u03bd\u03c4\u03b1\u03c2\u00a0 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03c0\u03b9\u03bf \u03c3\u03c5\u03bd\u03ae\u03b8\u03b7 \u03b5\u03be\u03ce\u03bd\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03b5\u03c0\u03af \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03ce\u03bd \u03b5\u03c0\u03b5\u03ba\u03c4\u03b5\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bf \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03c3\u03c4\u03b1 \u03c3\u03c0\u03b1\u03bd\u03b9\u03cc\u03c4\u03b5\u03c1\u03b1 \u03b5\u03be\u03ce\u03bd\u03b9\u03b1 (\u0395\u03b9\u03ba\u03cc\u03bd\u03b5\u03c2 4,5,6).<\/p>\n<p style=\"text-align: justify;\">\u0393\u03b9\u03b1 \u03c4\u03bf\u03bd \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03c4\u03bf\u03c5 \u03ba\u03c9\u03b4\u03b9\u03ba\u03cc\u03bd\u03b9\u03bf\u03c5 918 \u03c3\u03c4\u03bf \u03b5\u03be\u03ce\u03bd\u03b9\u03bf 16, \u03b5\u03c6\u03cc\u03c3\u03bf\u03bd \u03bf \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03ad\u03c7\u03b5\u03b9 \u03c4\u03bf\u03bd \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03cc \u03c6\u03b1\u03b9\u03bd\u03cc\u03c4\u03c5\u03c0\u03bf \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b4\u03c1\u03cc\u03bc\u03bf\u03c5 \u039c\u0395\u039d2\u0392 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03ba\u03cc\u03bc\u03b7 \u03ba\u03b1\u03b9 \u03b7 \u03ba\u03b1\u03c4\u03ac\u03c4\u03bc\u03b7\u03c3\u03b7 \u03bc\u03b5 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03cc \u03ad\u03bd\u03b6\u03c5\u03bc\u03bf \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03bf\u03bb\u03cd\u03c4\u03c9\u03c2 \u03b5\u03b9\u03b4\u03b9\u03ba\u03ae, \u03c0\u03bf\u03bb\u03cd \u03c3\u03c5\u03bd\u03c4\u03bf\u03bc\u03cc\u03c4\u03b5\u03c1\u03b7 \u03ba\u03b1\u03b9 \u03bf\u03b9\u03ba\u03bf\u03bd\u03bf\u03bc\u03b9\u03ba\u03cc\u03c4\u03b5\u03c1\u03b7 (\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 7). \u03a3\u03c4\u03b7\u03bd \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 1 \u03b1\u03c0\u03bf\u03c4\u03c5\u03c0\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 \u03b1\u03bb\u03bb\u03b7\u03bb\u03bf\u03c5\u03c7\u03af\u03b1\u03c2 DNA \u03c3\u03b5 \u03b3\u03ad\u03bb\u03b7 \u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03c6\u03cc\u03c1\u03b7\u03c3\u03b7\u03c2 \u03c3\u03b5 \u03b1\u03ba\u03c1\u03c5\u03bb\u03b1\u03bc\u03af\u03b4\u03b7 \u03b5\u03bd\u03cc\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae \u03bc\u03b5 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 \u03c3\u03c4\u03bf \u03b5\u03be\u03ce\u03bd\u03b9\u03bf 11 \u03ba\u03b1\u03b9 \u03b5\u03bd\u03cc\u03c2 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03bf\u03cd \u03bc\u03ac\u03c1\u03c4\u03c5\u03c1\u03b1. \u03a3\u03c4\u03b7\u03bd \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 2 \u03b1\u03c0\u03bf\u03c4\u03c5\u03c0\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c4\u03bf \u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03b3\u03c1\u03ac\u03c6\u03b7\u03bc\u03b1 \u03bc\u03b9\u03b1 \u03b1\u03bb\u03bb\u03b7\u03bb\u03bf\u03c5\u03c7\u03af\u03b1\u03c2 DNA \u03b1\u03c0\u03cc \u03b1\u03c5\u03c4\u03cc\u03bc\u03b1\u03c4\u03bf \u03b1\u03bd\u03b1\u03bb\u03c5\u03c4\u03ae \u03b1\u03bb\u03bb\u03b7\u03bb\u03bf\u03cd\u03c7\u03b7\u03c3\u03b7\u03c2\u00a0 DNA \u03b5\u03bd\u03cc\u03c2 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03bf\u03cd \u03b4\u03b5\u03af\u03b3\u03bc\u03b1\u03c4\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 3 \u03c4\u03bf \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03bf\u03b9\u03c7\u03bf\u00a0 \u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03b3\u03c1\u03ac\u03c6\u03b7\u03bc\u03b1 \u03b5\u03bd\u03cc\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03bf\u03cd\u03c2 \u03bf \u03bf\u03c0\u03bf\u03af\u03bf\u03c2 \u03c6\u03ad\u03c1\u03b5\u03b9 \u03c4\u03b7\u03bd \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 \u03c3\u03c4\u03bf \u03b5\u03be\u03ce\u03bd\u03b9\u03bf 8 \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03bf\u03c5 RET.<\/p>\n<hr style=\"width: 100%; border-width: 1px; border-style: solid; border-color: #CCCCCC; color: #ffffff;\" noshade=\"noshade\" width=\"100%\" \/>\n<p style=\"text-align: justify;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-1206\" alt=\"3.11image4\" src=\"https:\/\/e-endocrinology.gr\/wp-content\/uploads\/2015\/02\/3.11image4.jpg\" width=\"415\" height=\"234\" srcset=\"https:\/\/e-endocrinology.gr\/wp-content\/uploads\/2015\/02\/3.11image4.jpg 415w, https:\/\/e-endocrinology.gr\/wp-content\/uploads\/2015\/02\/3.11image4-300x169.jpg 300w\" sizes=\"(max-width: 415px) 100vw, 415px\" \/><\/p>\n<p style=\"text-align: justify;\"><b>\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 4.<\/b><\/p>\n<hr style=\"width: 100%; border-width: 1px; border-style: solid; border-color: #CCCCCC; color: #ffffff;\" noshade=\"noshade\" width=\"100%\" \/>\n<p style=\"text-align: justify;\"><a href=\"https:\/\/e-endocrinology.gr\/wp-content\/uploads\/2015\/02\/3.11image5.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-1207\" alt=\"3.11image5\" src=\"https:\/\/e-endocrinology.gr\/wp-content\/uploads\/2015\/02\/3.11image5.jpg\" width=\"415\" height=\"160\" srcset=\"https:\/\/e-endocrinology.gr\/wp-content\/uploads\/2015\/02\/3.11image5.jpg 415w, https:\/\/e-endocrinology.gr\/wp-content\/uploads\/2015\/02\/3.11image5-300x115.jpg 300w\" sizes=\"(max-width: 415px) 100vw, 415px\" \/><br \/>\n<\/a><b>\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 5.<\/b><a href=\"https:\/\/e-endocrinology.gr\/wp-content\/uploads\/2015\/02\/3.11image5.jpg\"><br \/>\n<\/a><\/p>\n<hr style=\"width: 100%; border-width: 1px; border-style: solid; border-color: #CCCCCC; color: #ffffff;\" noshade=\"noshade\" width=\"100%\" \/>\n<p style=\"text-align: justify;\"><a href=\"https:\/\/e-endocrinology.gr\/wp-content\/uploads\/2015\/02\/3.11image6.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-1208\" alt=\"3.11image6\" src=\"https:\/\/e-endocrinology.gr\/wp-content\/uploads\/2015\/02\/3.11image6.jpg\" width=\"415\" height=\"167\" srcset=\"https:\/\/e-endocrinology.gr\/wp-content\/uploads\/2015\/02\/3.11image6.jpg 415w, https:\/\/e-endocrinology.gr\/wp-content\/uploads\/2015\/02\/3.11image6-300x120.jpg 300w\" sizes=\"(max-width: 415px) 100vw, 415px\" \/><br \/>\n<\/a><b>\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 6.<\/b><a href=\"https:\/\/e-endocrinology.gr\/wp-content\/uploads\/2015\/02\/3.11image6.jpg\"><br \/>\n<\/a><\/p>\n<hr style=\"width: 100%; border-width: 1px; border-style: solid; border-color: #CCCCCC; color: #ffffff;\" noshade=\"noshade\" width=\"100%\" \/>\n<p style=\"text-align: justify;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-1209\" alt=\"3.11image7\" src=\"https:\/\/e-endocrinology.gr\/wp-content\/uploads\/2015\/02\/3.11image7.jpg\" width=\"409\" height=\"287\" srcset=\"https:\/\/e-endocrinology.gr\/wp-content\/uploads\/2015\/02\/3.11image7.jpg 409w, https:\/\/e-endocrinology.gr\/wp-content\/uploads\/2015\/02\/3.11image7-300x210.jpg 300w\" sizes=\"(max-width: 409px) 100vw, 409px\" \/><\/p>\n<p style=\"text-align: justify;\"><b>\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 7.<\/b><\/p>\n<hr style=\"width: 100%; border-width: 1px; border-style: solid; border-color: #CCCCCC; color: #ffffff;\" noshade=\"noshade\" width=\"100%\" \/>\n<h4 style=\"text-align: justify;\"><b>6. \u0391\u03bd\u03b1\u03b3\u03ba\u03b1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7\u03c2<\/b><\/h4>\n<p style=\"text-align: justify;\">\u03a4\u03bf \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf \u039c\u0395\u039d2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf \u03ba\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03bf \u03c0\u03b1\u03c1\u03ac\u03b4\u03b5\u03b9\u03b3\u03bc\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03ae\u03c2 \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae\u03c2\u00a0 \u03c3\u03c4\u03b7\u03bd \u03bf\u03b3\u03ba\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03bf\u03c5 \u03cc\u03c4\u03b9 \u03c0\u03c1\u03bf\u03c3\u03c6\u03ad\u03c1\u03b5\u03c4\u03b1\u03b9 \u03b4\u03c5\u03bd\u03b1\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1 \u03af\u03b1\u03c3\u03b7\u03c2 \u03c3\u03b5 \u03c0\u03c1\u03bf\u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03c3\u03c4\u03ac\u03b4\u03b9\u03bf (Cerrato et al Review 2009).<\/p>\n<p style=\"text-align: justify;\">\u039f \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u039c\u039a\u0398 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03bd\u03b1\u03b3\u03ba\u03b1\u03af\u03bf\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03bc\u03cc \u03c4\u03c9\u03bd \u03ba\u03bb\u03b7\u03c1\u03bf\u03bd\u03bf\u03bc\u03bf\u03cd\u03bc\u03b5\u03bd\u03c9\u03bd\u00a0 \u03bc\u03bf\u03c1\u03c6\u03ce\u03bd \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5. \u03a0\u03c1\u03cc\u03c3\u03c6\u03b1\u03c4\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b4\u03b7\u03bc\u03bf\u03c3\u03b9\u03b5\u03c5\u03c4\u03b5\u03af \u03ba\u03b1\u03c4\u03b5\u03c5\u03b8\u03c5\u03bd\u03c4\u03ae\u03c1\u03b9\u03b5\u03c2 \u03bf\u03b4\u03b7\u03b3\u03af\u03b5\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03cc \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03b1\u03c4\u03cc\u03bc\u03c9\u03bd \u03bc\u03b5 \u039c\u039a\u0398 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u0395\u03c5\u03c1\u03c9\u03c0\u03b1\u03ca\u03ba\u03ae \u0398\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae \u0395\u03c4\u03b1\u03b9\u03c1\u03b5\u03af\u03b1 (European Thyroid Journal 2012 Elisei et al).<\/p>\n<p style=\"text-align: justify;\">\u0395\u03c6\u03cc\u03c3\u03bf\u03bd \u03b5\u03bd\u03c4\u03bf\u03c0\u03b9\u03c3\u03c4\u03b5\u03af \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 \u03c3\u03c4\u03b7\u03bd \u03bf\u03b9\u03ba\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1 \u03c3\u03c4\u03b7\u03bd \u03c3\u03c5\u03bd\u03ad\u03c7\u03b5\u03b9\u03b1 \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c4\u03b1 \u03ba\u03bb\u03b7\u03c1\u03bf\u03bd\u03bf\u03bc\u03b9\u03ba\u03ce\u03c2 \u03c3\u03c5\u03bd\u03b4\u03b5\u03cc\u03bc\u03b5\u03bd\u03b1 \u03bc\u03ad\u03bb\u03b7 \u03c4\u03b7\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03b5\u03bd\u03c4\u03bf\u03c0\u03b9\u03c3\u03bc\u03cc \u00a0\u03c0\u03b9\u03b8\u03b1\u03bd\u03ce\u03bd \u03c6\u03bf\u03c1\u03ad\u03c9\u03bd \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03ad\u03b3\u03ba\u03b1\u03b9\u03c1\u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03ae \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03ce\u03c0\u03b9\u03c3\u03b7 \u03c4\u03bf\u03c5\u03c2. \u03a4\u03b1 \u03bc\u03ad\u03bb\u03b7 \u03c4\u03b7\u03c2 \u03bf\u03b9\u03ba\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1\u03c2 \u03c4\u03b1 \u03bf\u03c0\u03bf\u03af\u03b1 \u03b2\u03c1\u03af\u03c3\u03ba\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03ac \u03c9\u03c2 \u03c0\u03c1\u03bf\u03c2 \u03c4\u03b7\u03bd \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 \u03b1\u03c0\u03b1\u03bb\u03bb\u03ac\u03c3\u03c3\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c0\u03b5\u03c1\u03b1\u03b9\u03c4\u03ad\u03c1\u03c9 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf.<\/p>\n<p style=\"text-align: justify;\">\u0395\u03ac\u03bd \u03b4\u03b5\u03bd \u03b2\u03c1\u03b5\u03b8\u03b5\u03af \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 \u03c3\u03c4\u03bf\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae \u03c0\u03bf\u03c5 \u03c0\u03ac\u03c3\u03c7\u03b5\u03b9 \u03b1\u03c0\u03cc \u039c\u039a\u0398 \u03ba\u03b1\u03b9 \u03b4\u03b5\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03b3\u03bd\u03c9\u03c3\u03c4\u03cc \u03bf\u03b9\u03ba\u03bf\u03b3\u03b5\u03bd\u03b5\u03b9\u03b1\u03ba\u03cc \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc, \u03bf\u03b9 \u03c3\u03c5\u03b3\u03b3\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c0\u03c1\u03bf\u03c3\u03b4\u03b9\u03bf\u03c1\u03b9\u03c3\u03bc\u03cc \u03c4\u03c9\u03bd \u03b5\u03c0\u03b9\u03c0\u03ad\u03b4\u03c9\u03bd \u03ba\u03b1\u03bb\u03c3\u03b9\u03c4\u03bf\u03bd\u03af\u03bd\u03b7\u03c2. \u0397 \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03cc\u03bc\u03c9\u03c2 \u03bd\u03b1 \u03c0\u03c1\u03cc\u03ba\u03b5\u03b9\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03ba\u03bb\u03b7\u03c1\u03bf\u03bd\u03bf\u03bc\u03bf\u03cd\u03bc\u03b5\u03bd\u03b7 \u03bc\u03bf\u03c1\u03c6\u03ae \u03bc\u03b5 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf ret \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03bf\u03bb\u03cd \u03bc\u03b9\u03ba\u03c1\u03ae.<\/p>\n<p style=\"text-align: justify;\">\u0397 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03bd\u03b1\u03b3\u03ba\u03b1\u03af\u03b1 \u03c3\u03b5 \u03cc\u03bb\u03bf\u03c5\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u039c\u039a\u0398 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03b5\u03bd\u03c4\u03bf\u03c0\u03b9\u03c3\u03bc\u03cc \u03c0\u03b9\u03b8\u03b1\u03bd\u03ce\u03bd \u03bf\u03b9\u03ba\u03bf\u03b3\u03b5\u03bd\u03ce\u03bd \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03c9\u03bd \u03b1\u03ba\u03cc\u03bc\u03b7 \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03c6\u03b1\u03b9\u03bd\u03bf\u03bc\u03b5\u03bd\u03b9\u03ba\u03ac \u03c3\u03c0\u03bf\u03c1\u03b1\u03b4\u03b9\u03ba\u03cc \u039c\u039a\u0398.<\/p>\n<p style=\"text-align: justify;\">\u039f \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03bc\u03cc\u03c2 \u03c4\u03b7\u03c2 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7\u03c2 \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03c4\u03b7\u03bd \u03ba\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03c0\u03c1\u03cc\u03b3\u03bd\u03c9\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ae \u03ba\u03b1\u03c4\u03ac\u03bb\u03bb\u03b7\u03bb\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b1\u03b3\u03c9\u03b3\u03ae\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03c0\u03ac\u03c3\u03c7\u03bf\u03bd\u03c4\u03b1. \u0397 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03b1\u03be\u03af\u03b1 \u03cc\u03bc\u03c9\u03c2 \u03b1\u03c6\u03bf\u03c1\u03ac \u03c4\u03bf\u03c5\u03c2 \u03c0\u03c1\u03bf\u03b3\u03cc\u03bd\u03bf\u03c5\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03bf\u03c5\u03c2 \u03c3\u03c5\u03b3\u03b3\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03c1\u03ce\u03c4\u03bf\u03c5 \u03b2\u03b1\u03b8\u03bc\u03bf\u03cd \u03c3\u03c4\u03bf\u03c5\u03c2 \u03bf\u03c0\u03bf\u03af\u03bf\u03c5\u03c2 \u03c0\u03c1\u03bf\u03c3\u03c6\u03ad\u03c1\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03b4\u03c5\u03bd\u03b1\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c0\u03c1\u03bf\u03c6\u03c5\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b5\u03ba\u03c4\u03bf\u03bc\u03ae\u03c2 \u03b1\u03c6\u2019\u03cc\u03c3\u03bf\u03bd \u03b2\u03c1\u03b5\u03b8\u03bf\u03cd\u03bd \u03c6\u03bf\u03c1\u03b5\u03af\u03c2 \u03c4\u03b7\u03c2 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7\u03c2.<\/p>\n<h4 style=\"text-align: justify;\"><b>\u0392\u03b9\u03b2\u03bb\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1<\/b><b><\/b><\/h4>\n<ol style=\"text-align: justify;\">\n<li>Carlson KM, Dou S, Chi D, Scavarda N, Toshima K, Jackson CE, Wells SA, Godfellow PJ, Donis-Keller H 1994 Single missence mutation in the tyrosine kinase catalytic domain of the RET protooncogene is associated with multiple endocrine neoplasia type 2B. <i>Proc Natl Acad Sci USA<\/i> 91(4):1579-1583.<\/li>\n<li>Cerrato A, De Falco, Santro M. 2009 Molecular genetics of medullary thyroid carcinoma: the quest for novel therapeutic targets. <i>J of Mol Endocrinol<\/i> 43:143-15.<\/li>\n<li>Donis-Keller H, Dou S, Chi D, Carlson KN, Toshima K, Lairmore TC, Howe JR, Moey JF, Goodfellow P, Wells SA 1993 Mutations in the RET proto-oncogene are associated with MEN2A and FMTC. <i>Hum Mol Genet <\/i>2(7):851-856.<\/li>\n<li>Elisei R, Romei C, Cosci B, Molinaro E, Agate L, Bottici V, Pinchera A. 2008 RET point mutations in Thyroid Carcinoma. <i>Atlas of Genetics and Cytogenetics in Oncology and Haematology <\/i>April 2008<i>.<\/i><\/li>\n<li>Elisei R, Alevizaki M, Conte-Devolx B, Frank-Raue K, Leite V, Williams GR 2012. 2012 European Thyroid Association Guidelines for Genetic Testing and Its Clinical Consequences in Medullary Thyroid Cancer <i>Eur Thyroid J<\/i> 1:216\u2013231.<\/li>\n<li>Eng C, Smith DP, Mulligan LM, Nagai MA, Healey CS, Ponder MA, Gardner E, Scheumann GF, Jackson CE, Tunnacliffe A et al 1994 Point mutation within the tyrosine kinase domain of the RET proto-oncogene in multiple endocrine neoplasia type 2B and related sporadic tumours.<i> Hum Mol Genet<\/i> 3(2):237-241.<\/li>\n<li>Eng C, Clayton D, Schuffenecker I, Lenoir G, Cote G, Gagel R et al 1996 The Relationship Between Specific <i>RET<\/i> Proto-oncogene Mutations and Disease Phenotype in Multiple Endocrine Neoplasia Type 2. <i>JAMA <\/i>19:1575-1579.<\/li>\n<li>De Groot JW, Links T, Plukker JT, Lips C, Hofstra RM. 2006 RET as a Diagnostic and Therapeutic Target in Sporadic and Hereditary Endocrine Tumors.<i>Endocrine Reviews <\/i>27(5):535-560.<\/li>\n<li>Hazard JB, Hawk WA, Grile G, Jr 1959 Medullary (solid) carcinoma oh the thyroid; a clinicopathologic entity. <i>J Clin Endocrinol Matab <\/i>19:152-161.<\/li>\n<li>Hofstra RM, Landsvater RM, Ceccherini I, Stulp RP, Stelwagen T, Luo Y, Pasini B, Hoppener JW, van Amstel HK, Romeo G, et al 1994 A mutation in the RET proto-oncogene associated with multiple endocrine neoplasia type 2B and sporadic medullary thyroid carcinoma. <i>Nature <\/i>27; 367(6461):375-376.<\/li>\n<li>Kloos R, Eng C, Evans D, Francis G, Gagel R,\u00a0 Gharib H, Moley J, Pacini F, Ringel M, Schlumberger M and Wells S 2009 Medullary Thyroid Cancer:<\/li>\n<li>Management Guidelines of the American Thyroid Association. <i>Thyroid<\/i>19:565-612.<\/li>\n<li>Kouvaraki MA, Shapiro SE, Perrier ND, Cote GJ, Gagel RF, Sherman SI, Lee JE,\u00a0 Evans DB 2005 RET proto-oncogene: a review and update of genotype-phenotype correlations in hereditary medullary thyroid cancer and associated endocrine tumors. <i>Thyroid<\/i> 15(6):531-544.<\/li>\n<li>Mulligan \u00a0LM, Kwok JB, Healey CS, Elsdon MJ, Eng C, Gardner E, Love DR, Mole SE, Moore JK, Papi L, et al 1993 Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A. <i>Nature<\/i> 363(6428):458-460<\/li>\n<li>Sarika HL, Papathoma A, Garofalaki M, Vasileiou V, Vlassopoulou B, Anastasiou E, Alevizaki M. 2012 High prevalence of exon 8 g533c mutation in apparently sporadic medullary thyroid carcinoma (mtc) in Greece). <i>Clin Endocrinol <\/i>77(6):857-62.<\/li>\n<\/ol>\n<hr style=\"width: 100%; border-width: 1px; border-style: solid; border-color: #CCCCCC; color: #ffffff;\" noshade=\"noshade\" width=\"100%\" \/>\n<p>Created: October 25, 2014<br \/>\nLast update: October 25, 2014<\/p>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; \u039b\u03ae\u03b4\u03b1 \u03a3\u03b1\u03c1\u03af\u03ba\u03b1 \u0392\u03b9\u03bf\u03bb\u03cc\u03b3\u03bf\u03c2 \u0395\u03bd\u03b4\u03bf\u03ba\u03c1\u03b9\u03bd\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u039c\u03bf\u03bd\u03ac\u03b4\u03b1 \u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae\u03c2 \u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03a0\u03b1\u03bd\u03b5\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03af\u03bf\u03c5 \u0391\u03b8\u03b7\u03bd\u03ce\u03bd \u039c\u03b1\u03c1\u03af\u03b1 \u0391\u03bb\u03b5\u03b2\u03b9\u03b6\u03ac\u03ba\u03b7 \u0395\u03bd\u03b4\u03bf\u03ba\u03c1\u03b9\u03bd\u03bf\u03bb\u03cc\u03b3\u03bf\u03c2 \u0395\u03bd\u03b4\u03bf\u03ba\u03c1\u03b9\u03bd\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u039c\u03bf\u03bd\u03ac\u03b4\u03b1 \u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae\u03c2 \u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03a0\u03b1\u03bd\u03b5\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03af\u03bf\u03c5 \u0391\u03b8\u03b7\u03bd\u03ce\u03bd 1. \u0395\u03b9\u03c3\u03b1\u03b3\u03c9\u03b3\u03ae \u03a4\u03bf \u03bc\u03c5\u03b5\u03bb\u03bf\u03b5\u03b9\u03b4\u03ad\u03c2 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03c9\u03bc\u03b1 \u03c4\u03bf\u03c5 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03bf\u03cd\u03c2 (\u039c\u039a\u0398) \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1\u03c2 \u03c3\u03c0\u03ac\u03bd\u03b9\u03bf\u03c2 \u03ba\u03b1\u03ba\u03bf\u03ae\u03b8\u03b7\u03c2 \u03cc\u03b3\u03ba\u03bf\u03c2 \u03bf \u03bf\u03c0\u03bf\u03af\u03bf\u03c2 \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03ac\u03c6\u03b7\u03ba\u03b5 \u03b3\u03b9\u03b1 \u03c0\u03c1\u03ce\u03c4\u03b7 \u03c6\u03bf\u03c1\u03ac \u03c4\u03bf 1959 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd Hazard (Hazard et al 1959). \u0391\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03c4\u03bf 4-10% \u03c4\u03c9\u03bd \u03bd\u03b5\u03bf\u03c0\u03bb\u03b1\u03c3\u03bc\u03ac\u03c4\u03c9\u03bd \u03c4\u03bf\u03c5 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03bf\u03cd\u03c2, \u03c0\u03c1\u03bf\u03ad\u03c1\u03c7\u03b5\u03c4\u03b1\u03b9 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"pageCustom.php","meta":{"footnotes":""},"tags":[],"_links":{"self":[{"href":"https:\/\/e-endocrinology.gr\/index.php?rest_route=\/wp\/v2\/pages\/1115"}],"collection":[{"href":"https:\/\/e-endocrinology.gr\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/e-endocrinology.gr\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/e-endocrinology.gr\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/e-endocrinology.gr\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1115"}],"version-history":[{"count":8,"href":"https:\/\/e-endocrinology.gr\/index.php?rest_route=\/wp\/v2\/pages\/1115\/revisions"}],"predecessor-version":[{"id":1117,"href":"https:\/\/e-endocrinology.gr\/index.php?rest_route=\/wp\/v2\/pages\/1115\/revisions\/1117"}],"wp:attachment":[{"href":"https:\/\/e-endocrinology.gr\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1115"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/e-endocrinology.gr\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1115"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}