{"id":1108,"date":"2015-02-23T22:59:17","date_gmt":"2015-02-23T19:59:17","guid":{"rendered":"http:\/\/e-endocrinology.gr\/?page_id=1108"},"modified":"2015-03-19T13:59:29","modified_gmt":"2015-03-19T10:59:29","slug":"3-8-4-%ce%bf%ce%b9%ce%ba%ce%bf%ce%b3%ce%b5%ce%bd%ce%ae%cf%82-%cf%85%cf%80%ce%b5%cf%81%cf%87%ce%bf%ce%bb%ce%b7%cf%83%cf%84%ce%b5%cf%81%ce%bf%ce%bb%ce%b1%ce%b9%ce%bc%ce%af%ce%b1-%ce%ba%ce%b1%ce%b9","status":"publish","type":"page","link":"https:\/\/e-endocrinology.gr\/?page_id=1108","title":{"rendered":"3.8.4 \u039f\u03b9\u03ba\u03bf\u03b3\u03b5\u03bd\u03ae\u03c2 \u03c5\u03c0\u03b5\u03c1\u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03bf\u03bb\u03b1\u03b9\u03bc\u03af\u03b1 \u03ba\u03b1\u03b9 \u03ac\u03bb\u03bb\u03b5\u03c2 \u03b4\u03c5\u03c3\u03bb\u03b9\u03c0\u03b9\u03b4\u03b1\u03b9\u03bc\u03af\u03b5\u03c2"},"content":{"rendered":"<p style=\"text-align: right;\"><div class=\"printfriendly pf-button  pf-alignright\">\n                    <a href=\"https:\/\/e-endocrinology.gr\/?page_id=1108&#038;pfstyle=wp\" rel=\"nofollow\" onclick=\"\" title=\"Printer Friendly, PDF & Email\">\n                    <img decoding=\"async\" class=\"pf-button-img\" src=\"https:\/\/cdn.printfriendly.com\/buttons\/printfriendly-pdf-button-nobg.png\" alt=\"Print Friendly, PDF & Email\" style=\"width: 112px;height: 24px;\"  \/>\n                    <\/a>\n                <\/div><\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: right;\"><em>\u0391\u03bd\u03b1\u03c3\u03c4\u03b1\u03c3\u03af\u03b1 \u039a\u03b5\u03ae<\/em><br \/>\n\u0399\u03b1\u03c4\u03c1\u03cc\u03c2<br \/>\n\u0395\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03bf\u03bd\u03b9\u03ba\u03cc\u03c2 \u03a3\u03c5\u03bd\u03b5\u03c1\u03b3\u03ac\u03c4\u03b7\u03c2 \u03c4\u03bf\u03c5 \u0399\u03b1\u03c4\u03c1\u03b5\u03af\u03bf\u03c5 \u039c\u03b5\u03bb\u03ad\u03c4\u03b7\u03c2 \u03c4\u03c9\u03bd \u0394\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ce\u03bd<br \/>\n\u03c4\u03bf\u03c5 \u039c\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03c3\u03bc\u03bf\u03cd \u03c4\u03c9\u03bd \u039b\u03b9\u03c0\u03b9\u03b4\u03af\u03c9\u03bd \u03c4\u03bf\u03c5 \u03a0\u03b1\u03bd\u03b5\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03b9\u03b1\u03ba\u03bf\u03cd \u039d\u03bf\u03c3\u03bf\u03ba\u03bf\u03bc\u03b5\u03af\u03bf\u03c5 \u0399\u03c9\u03b1\u03bd\u03bd\u03af\u03bd\u03c9\u03bd<\/p>\n<p style=\"text-align: right;\"><em>\u03a7\u03b1\u03c1\u03ac\u03bb\u03b1\u03bc\u03c0\u03bf\u03c2 \u039c\u03b7\u03bb\u03b9\u03ce\u03bd\u03b7\u03c2<\/em><br \/>\n\u0391\u03bd\u03b1\u03c0\u03bb\u03b7\u03c1\u03c9\u03c4\u03ae\u03c2 \u039a\u03b1\u03b8\u03b7\u03b3\u03b7\u03c4\u03ae\u03c2 \u03a0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03af\u03b1\u03c2<br \/>\n\u0399\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03a3\u03c7\u03bf\u03bb\u03ae \u03a0\u03b1\u03bd\u03b5\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03af\u03bf\u03c5 \u0399\u03c9\u03b1\u03bd\u03bd\u03af\u03bd\u03c9\u03bd<\/p>\n<h4 style=\"text-align: justify;\"><b>1. \u0395\u03b9\u03c3\u03b1\u03b3\u03c9\u03b3\u03ae<\/b><\/h4>\n<p style=\"text-align: justify;\">\u0397 \u03bf\u03b9\u03ba\u03bf\u03b3\u03b5\u03bd\u03ae\u03c2 \u03c5\u03c0\u03b5\u03c1\u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03bf\u03bb\u03b1\u03b9\u03bc\u03af\u03b1 (Familial Hypercholesterolemia, FH) \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b5\u03c1\u03b7 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ae \u03c4\u03bf\u03c5 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03c3\u03bc\u03bf\u03cd. \u03a7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c5\u03c8\u03b7\u03bb\u03ac \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2 \u03c4\u03c9\u03bd \u03c7\u03b1\u03bc\u03b7\u03bb\u03ae\u03c2 \u03c0\u03c5\u03ba\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03bb\u03b9\u03c0\u03bf\u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03ce\u03bd (low density lipoprotein cholesterol, LDL-C) \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03b5\u03bd\u03b1\u03c0\u03bf\u03c4\u03af\u03b8\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b9\u03c3\u03c4\u03bf\u03cd\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7\u03bd \u00a0\u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7 \u03c4\u03b5\u03bd\u03cc\u03bd\u03c4\u03b9\u03c9\u03bd \u03be\u03b1\u03bd\u03b8\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03c3\u03c4\u03b9\u03c2 \u03b5\u03ba\u03c4\u03b1\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b5\u03c0\u03b9\u03c6\u03ac\u03bd\u03b5\u03b9\u03b5\u03c2 \u03c4\u03c9\u03bd \u03c4\u03b5\u03bd\u03cc\u03bd\u03c4\u03c9\u03bd, \u03be\u03b1\u03bd\u03b8\u03b5\u03bb\u03b1\u03c3\u03bc\u03ac\u03c4\u03c9\u03bd \u03c3\u03c4\u03b7\u03bd \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ae \u03c4\u03c9\u03bd \u03bf\u03c6\u03b8\u03b1\u03bb\u03bc\u03ce\u03bd \u03ba\u03b1\u03b9 \u03b3\u03b5\u03c1\u03bf\u03bd\u03c4\u03cc\u03c4\u03bf\u03be\u03bf\u03c5. \u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03c4\u03bf \u03ba\u03cd\u03c1\u03b9\u03bf \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03cc \u03c4\u03b7\u03c2 FH \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03b7 \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7 \u03c0\u03c1\u03ce\u03b9\u03bc\u03b7\u03c2 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ae\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5 (1). \u0397 \u03bd\u03cc\u03c3\u03bf\u03c2 \u03ba\u03bb\u03b7\u03c1\u03bf\u03bd\u03bf\u03bc\u03b5\u03af\u03c4\u03b1\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03b1\u03c5\u03c4o\u03c3\u03c9\u03bc\u03b9\u03ba\u03cc \u03b5\u03c0\u03b9\u03ba\u03c1\u03b1\u03c4\u03bf\u03cd\u03bd\u03c4\u03b1 \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03ae\u03c1\u03b1, \u03b5\u03bd\u03ce \u03ad\u03c7\u03bf\u03c5\u03bd \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03b1\u03c6\u03b5\u03af \u03ba\u03b1\u03b9 \u03c3\u03c0\u03ac\u03bd\u03b9\u03b5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03b1\u03c5\u03c4\u03bf\u03c3\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c5\u03c0\u03bf\u03bb\u03b5\u03b9\u03c0\u03cc\u03bc\u03b5\u03bd\u03b7\u03c2 \u03ba\u03bb\u03b7\u03c1\u03bf\u03bd\u03bf\u03bc\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2. \u039f \u03b5\u03c0\u03b9\u03c0\u03bf\u03bb\u03b1\u03c3\u03bc\u03cc\u03c2 \u03c4\u03c9\u03bd \u03b5\u03c4\u03b5\u03c1\u03bf\u03b6\u03c5\u03b3\u03c9\u03c4\u03ce\u03bd \u03bc\u03b5 FH \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c4\u03bf \u03b3\u03b5\u03bd\u03b9\u03ba\u03cc \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03cc 1:500 (\u03c3\u03b5 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2 \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03bf\u03cd\u03c2 \u03b1\u03bd\u03b1\u03c6\u03ad\u03c1\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b1\u03ba\u03cc\u03bc\u03b7 \u03ba\u03b1\u03b9 1:200), \u03b5\u03bd\u03ce \u03c4\u03c9\u03bd \u03bf\u03bc\u03bf\u03b6\u03c5\u03b3\u03c9\u03c4\u03ce\u03bd 1:1.000.000 \u03ac\u03c4\u03bf\u03bc\u03b1 (1)<b><br \/>\n<\/b><\/p>\n<h4 style=\"text-align: justify;\"><b>2. \u0393\u03bf\u03bd\u03b9\u03b4\u03b9\u03b1\u03ba\u03cc \u03c5\u03c0\u03cc\u03b2\u03b1\u03b8\u03c1\u03bf<\/b><\/h4>\n<p style=\"text-align: justify;\">H \u03b5\u03c4\u03b5\u03c1\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1 \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 FH \u03ad\u03c7\u03b5\u03b9 \u03c3\u03c5\u03c3\u03c7\u03b5\u03c4\u03b9\u03c3\u03b8\u03b5\u03af \u03c3\u03b5 \u03b4\u03b9\u03ac\u03c6\u03bf\u03c1\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03bc\u03b5 \u03c4\u03bf \u03b5\u03af\u03b4\u03bf\u03c2 \u03c4\u03b7\u03c2 \u03c5\u03c0\u03bf\u03ba\u03b5\u03af\u03bc\u03b5\u03bd\u03b7\u03c2 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b9\u03c2 \u03c5\u03b3\u03b9\u03b5\u03b9\u03bd\u03bf\u03b4\u03b9\u03b1\u03b9\u03c4\u03b7\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c3\u03c5\u03bd\u03ae\u03b8\u03b5\u03b9\u03b5\u03c2. \u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03b1\u03be\u03af\u03b6\u03b5\u03b9 \u03bd\u03b1 \u03c3\u03b7\u03bc\u03b5\u03b9\u03c9\u03b8\u03b5\u03af \u03cc\u03c4\u03b9 \u03c3\u03c4\u03bf 17-33% \u03c4\u03c9\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03bc\u03b5 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 FH \u03b4\u03b5\u03bd \u03b5\u03bd\u03c4\u03bf\u03c0\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03ba\u03b1\u03bc\u03af\u03b1 \u03b1\u03c0\u03bf\u03b4\u03b5\u03b4\u03b5\u03b9\u03b3\u03bc\u03ad\u03bd\u03b7 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 \u03c3\u03c4\u03b1 \u03b3\u03bd\u03c9\u03c3\u03c4\u03ac \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1.<\/p>\n<h5 style=\"text-align: justify;\"><b>2.1. \u039c\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03bf\u03c5 \u03c4\u03bf\u03c5 <\/b><b>LDL \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 <\/b><\/h5>\n<p style=\"text-align: justify;\">\u0397 \u03ba\u03cd\u03c1\u03b9\u03b1 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ae \u03b1\u03c6\u03bf\u03c1\u03ac \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03bf\u03c5 \u03c0\u03bf\u03c5 \u03ba\u03c9\u03b4\u03b9\u03ba\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03c4\u03bf\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03c4\u03b7\u03c2 LDL \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2 (LDL receptor, LDL-R) \u03ba\u03b1\u03b9 \u03b5\u03b4\u03c1\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf \u03c7\u03c1\u03c9\u03bc\u03cc\u03c3\u03c9\u03bc\u03b1 19 (19p13.1-13.3). \u039f LDL-R \u03b1\u03bc\u03ad\u03c3\u03c9\u03c2 \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7 \u03c3\u03cd\u03bd\u03b8\u03b5\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b3\u03bb\u03c5\u03ba\u03bf\u03b6\u03c5\u03bb\u03b9\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03bc\u03b5\u03c4\u03b1\u03c6\u03ad\u03c1\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03c6\u03ac\u03bd\u03b5\u03b9\u03b1 \u03c4\u03bf\u03c5 \u03b7\u03c0\u03b1\u03c4\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03bf\u03c5 \u03bc\u03ad\u03c3\u03b1 \u03c3\u03b5 \u03b2\u03bf\u03b8\u03c1\u03af\u03b1 \u03ba\u03bb\u03b1\u03b8\u03c1\u03af\u03bd\u03b7\u03c2, \u03cc\u03c0\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bd\u03b4\u03ad\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b1\u03c0\u03bf\u03bb\u03b9\u03c0\u03bf\u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 \u0392 (apolipoprotein B, apoB) \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03b2\u03c1\u03af\u03c3\u03ba\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03c6\u03ac\u03bd\u03b5\u03b9\u03b1 \u03c4\u03c9\u03bd LDL \u03c3\u03c9\u03bc\u03b1\u03c4\u03b9\u03b4\u03af\u03c9\u03bd. \u03a4\u03bf \u03c3\u03cd\u03bc\u03c0\u03bb\u03b5\u03b3\u03bc\u03b1 \u00ab\u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1\/LDL\u00bb \u03b5\u03bd\u03b4\u03bf\u03ba\u03c5\u03c4\u03c4\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03bc\u03b5\u03c4\u03b1\u03bd\u03b1\u03c3\u03c4\u03b5\u03cd\u03b5\u03b9 \u03c3\u03c4\u03b1 \u03b5\u03bd\u03b4\u03bf\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1, \u03cc\u03c0\u03bf\u03c5 \u03bb\u03cc\u03b3\u03c9 \u03c4\u03bf\u03c5 \u03cc\u03be\u03b9\u03bd\u03bf\u03c5 \u03c0\u03b5\u03c1\u03b9\u03b2\u03ac\u03bb\u03bb\u03bf\u03bd\u03c4\u03bf\u03c2 \u03c4\u03bf \u03c3\u03c9\u03bc\u03b1\u03c4\u03af\u03b4\u03b9\u03bf LDL \u03b1\u03c0\u03b5\u03bb\u03b5\u03c5\u03b8\u03b5\u03c1\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd LDL-R \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03c3\u03c5\u03bd\u03ad\u03c7\u03b5\u03b9\u03b1 \u03ba\u03b1\u03c4\u03b1\u03b2\u03bf\u03bb\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b1 \u03bb\u03c5\u03c3\u03bf\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1. \u039f LDL-R \u03b5\u03c0\u03b9\u03c3\u03c4\u03c1\u03ad\u03c6\u03b5\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03c6\u03ac\u03bd\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae\u03c2 \u03bc\u03b5\u03bc\u03b2\u03c1\u03ac\u03bd\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03be\u03b5\u03ba\u03b9\u03bd\u03ac \u03ad\u03bd\u03b1\u03c2 \u03bd\u03ad\u03bf\u03c2 \u03ba\u03cd\u03ba\u03bb\u03bf\u03c2. \u039c\u03ad\u03c7\u03c1\u03b9 \u03c3\u03ae\u03bc\u03b5\u03c1\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03b1\u03c6\u03b5\u03af \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03b1\u03c0\u03cc 1700 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03bf\u03b9 \u03bf\u03c0\u03bf\u03af\u03b5\u03c2 \u03b5\u03bd\u03c4\u03bf\u03c0\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03cc\u03bb\u03b5\u03c2 \u03c3\u03c7\u03b5\u03b4\u03cc\u03bd \u03c4\u03b9\u03c2 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ad\u03c2 \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03bf\u03c5 \u03c4\u03bf\u03c5 LDL-R (2). \u039f\u03b9 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03bf\u03c5 \u03c4\u03bf\u03c5 LDL-R \u03ad\u03c7\u03bf\u03c5\u03bd 100% \u03b4\u03b9\u03b5\u03b9\u03c3\u03b4\u03c5\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03bf\u03b9 \u03c6\u03bf\u03c1\u03b5\u03af\u03c2 \u03bd\u03b1 \u03ba\u03bb\u03b7\u03c1\u03bf\u03b4\u03bf\u03c4\u03bf\u03cd\u03bd \u03c4\u03b7 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 \u03c3\u03c4\u03bf 50% \u03c4\u03c9\u03bd \u03b1\u03c0\u03bf\u03b3\u03cc\u03bd\u03c9\u03bd \u03c4\u03bf\u03c5\u03c2. \u039c\u03b5 \u03b2\u03ac\u03c3\u03b7 \u03c4\u03b7 \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03c6\u03bf\u03c1\u03ac \u03c4\u03b7\u03c2 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03b1\u03b3\u03bc\u03ad\u03bd\u03b7\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2 \u03b4\u03b9\u03b1\u03ba\u03c1\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c0\u03ad\u03bd\u03c4\u03b5 \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b5\u03c2 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03c9\u03bd \u03c4\u03bf\u03c5 LDL-R (3):<\/p>\n<ol style=\"text-align: justify;\">\n<li>\u039c\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03c0\u03bf\u03c5 \u03b1\u03c6\u03bf\u03c1\u03bf\u03cd\u03bd \u03c4\u03b7 \u03c3\u03cd\u03bd\u03b8\u03b5\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 (\u201cnull alleles\u201d) \u03c3\u03c4\u03b9\u03c2 \u03bf\u03c0\u03bf\u03af\u03b5\u03c2 \u03c4\u03bf \u03b1\u03b3\u03b3\u03b5\u03bb\u03b9\u03b1\u03c6\u03cc\u03c1\u03bf RNA (messenger RNA, mRNA) \u03b5\u03af\u03c4\u03b5 \u03b4\u03b5\u03bd \u03c0\u03b1\u03c1\u03ac\u03b3\u03b5\u03c4\u03b1\u03b9, \u03b5\u03af\u03c4\u03b5 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03cc, \u03b5\u03af\u03c4\u03b5 \u03c0\u03b1\u03c1\u03ac\u03b3\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03bc\u03b9\u03ba\u03c1\u03ad\u03c2 \u03c3\u03c5\u03b3\u03ba\u03b5\u03bd\u03c4\u03c1\u03ce\u03c3\u03b5\u03b9\u03c2 (4). \u0391\u03c5\u03c4\u03ae \u03b7 \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b1 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03c9\u03bd \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03c3\u03c5\u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c3\u03bf\u03b2\u03b1\u03c1\u03ad\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b5\u03ba\u03b4\u03b7\u03bb\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5.<\/li>\n<li>\u039c\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03c0\u03bf\u03c5 \u03b1\u03c6\u03bf\u03c1\u03bf\u03cd\u03bd \u03c4\u03b7\u03bd \u03c4\u03c1\u03b9\u03c3\u03b4\u03b9\u03ac\u03c3\u03c4\u03b1\u03c4\u03b7 \u03b4\u03bf\u03bc\u03ae \u03c4\u03c9\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03c9\u03bd \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03bd\u03b1 \u03b1\u03bd\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03b5\u03c4\u03b1\u03b9 \u03c0\u03bb\u03ae\u03c1\u03c9\u03c2 \u03ae \u03b5\u03bd \u03bc\u03ad\u03c1\u03b5\u03b9 \u03b7 \u03bc\u03b5\u03c4\u03b1\u03c6\u03bf\u03c1\u03ac \u03c4\u03bf\u03c5\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf \u03b5\u03bd\u03b4\u03bf\u03c0\u03bb\u03b1\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc \u03b4\u03af\u03ba\u03c4\u03c5\u03bf \u03c3\u03c4\u03b7 \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03ae Golgi (5).<\/li>\n<li>\u039c\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03c0\u03bf\u03c5 \u03b5\u03c0\u03b7\u03c1\u03c1\u03b5\u03ac\u03b6\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03b9\u03ba\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c3\u03cd\u03bd\u03b4\u03b5\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03bc\u03b5 \u03c4\u03b1 LDL \u03c3\u03c9\u03bc\u03b1\u03c4\u03af\u03b4\u03b9\u03b1. \u03a6\u03b1\u03b9\u03bd\u03bf\u03c4\u03c5\u03c0\u03b9\u03ba\u03ac \u03bf\u03b9 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03b1\u03c5\u03c4\u03ae\u03c2 \u03c4\u03b7\u03c2 \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b1\u03c2 \u03b5\u03ba\u03b4\u03b7\u03bb\u03ce\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b7 \u03b5\u03c4\u03b5\u03c1\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1 \u03ba\u03b1\u03b8\u03ce\u03c2 \u03b7 \u03b9\u03ba\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c0\u03c1\u03cc\u03c3\u03b4\u03b5\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03b1\u03b3\u03bc\u03ad\u03bd\u03bf\u03c5 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03c0\u03bf\u03b9\u03ba\u03af\u03bb\u03b5\u03b9 \u03b1\u03c0\u03cc 2% \u03ad\u03c9\u03c2 30% \u03c4\u03b7\u03c2 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae\u03c2 (6).<\/li>\n<li>\u039c\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03b5\u03bc\u03c0\u03bf\u03b4\u03af\u03b6\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03b5\u03bd\u03b4\u03bf\u03ba\u03cd\u03c4\u03c4\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bc\u03c0\u03bb\u03ad\u03b3\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1- LDL, \u03b5\u03bd\u03ce \u03b7 \u03c3\u03cd\u03bd\u03b4\u03b5\u03c3\u03b7 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03c4\u03bf\u03c5\u03c2 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03ba\u03b1\u03bd\u03bf\u03bd\u03b9\u03ba\u03ac (7).<\/li>\n<li>\u039c\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03c0\u03bf\u03c5 \u03b1\u03bd\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03b1\u03bd\u03b1\u03ba\u03cd\u03ba\u03bb\u03b9\u03c3\u03b7 (\u03b5\u03c0\u03b1\u03bd\u03b1\u03c6\u03bf\u03c1\u03ac) \u03c4\u03bf\u03c5 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03c3\u03c4\u03b7\u03bd \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03bc\u03b5\u03bc\u03b2\u03c1\u03ac\u03bd\u03b7, \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7\u03bd \u03b1\u03c0\u03b5\u03bb\u03b5\u03c5\u03b8\u03ad\u03c1\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd LDL \u03c3\u03c4\u03bf \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03cc\u03c0\u03bb\u03b1\u03c3\u03bc\u03b1 \u03c4\u03c9\u03bd \u03b7\u03c0\u03b1\u03c4\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd (8).<\/li>\n<\/ol>\n<p style=\"text-align: justify;\">\u03a3\u03b7\u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03c3\u03c4\u03b7 \u03b2\u03b1\u03c1\u03cd\u03c4\u03b7\u03c4\u03b1 \u03c4\u03c9\u03bd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ce\u03bd \u03b5\u03ba\u03b4\u03b7\u03bb\u03ce\u03c3\u03b5\u03c9\u03bd \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5 \u03b5\u03ba\u03c4\u03cc\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b1 \u03c4\u03b7\u03c2 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7\u03c2 \u03c0\u03b1\u03af\u03b6\u03b5\u03b9 \u03c1\u03cc\u03bb\u03bf \u03ba\u03b1\u03b9 \u03bf \u03b1\u03c1\u03b9\u03b8\u03bc\u03cc\u03c2 \u03c4\u03c9\u03bd \u03b1\u03bd\u03c4\u03b9\u03b3\u03c1\u03ac\u03c6\u03c9\u03bd \u03c4\u03bf\u03c5 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03b1\u03b3\u03bc\u03ad\u03bd\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03bf\u03c5 \u03b1\u03bd\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03bf.<\/p>\n<h5 style=\"text-align: justify;\"><b>2.2. \u039c\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03bf\u03c5 \u03c4\u03b7\u03c2 <\/b><b>ApoB-100<\/b><\/h5>\n<p style=\"text-align: justify;\">\u03a5\u03c0\u03bf\u03bb\u03bf\u03b3\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03c4\u03bf\u03c5\u03bb\u03ac\u03c7\u03b9\u03c3\u03c4\u03bf\u03bd 2-5% \u03c4\u03c9\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03bc\u03b5 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03bc\u03ad\u03bd\u03b7 FH \u03b5\u03af\u03bd\u03b1\u03b9 \u03c6\u03bf\u03c1\u03b5\u03af\u03c2 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03c9\u03bd \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03bf\u03c5 \u03c4\u03b7\u03c2 apoB-100 (9). H apoB-100 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c5\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03cc \u03c4\u03c9\u03bd LDL \u03c3\u03c9\u03bc\u03b1\u03c4\u03b9\u03b4\u03af\u03c9\u03bd \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03c4\u03bf \u03c3\u03b7\u03bc\u03b5\u03af\u03bf \u03c0\u03c1\u03cc\u03c3\u03b4\u03b5\u03c3\u03b7\u03c2 \u03bc\u03b5 \u03c4\u03bf\u03bd LDL-R. \u039c\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03c0\u03bf\u03c5 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c9\u03c2 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03b7 \u03bc\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03b9\u03ba\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c0\u03c1\u03cc\u03c3\u03b4\u03b5\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 apoB-100 \u03c3\u03c4\u03bf\u03bd LDL-R \u03b5\u03ba\u03b4\u03b7\u03bb\u03ce\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03c9\u03c2 FH. \u0397 \u03bc\u03b5\u03c4\u03b1\u03b2\u03af\u03b2\u03b1\u03c3\u03b7 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03b1\u03c5\u03c4\u03bf\u03c3\u03c9\u03bc\u03b9\u03ba\u03cc \u03b5\u03c0\u03b9\u03ba\u03c1\u03b1\u03c4\u03bf\u03cd\u03bd\u03c4\u03b1 \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03ae\u03c1\u03b1, \u03bc\u03b5 \u03ba\u03cd\u03c1\u03b9\u03bf \u03b5\u03ba\u03c0\u03c1\u03cc\u03c3\u03c9\u03c0\u03bf \u03c4\u03b7\u03bd R3500Q, \u03b5\u03bd\u03ce \u03bb\u03b9\u03b3\u03cc\u03c4\u03b5\u03c1\u03bf \u03c3\u03c5\u03c7\u03bd\u03ad\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf\u03b9 R3500W, R3531C \u03ba\u03b1\u03b9 H3543Y (10). \u0391\u03be\u03af\u03b6\u03b5\u03b9 \u03bd\u03b1 \u03c3\u03b7\u03bc\u03b5\u03b9\u03c9\u03b8\u03b5\u03af \u03cc\u03c4\u03b9 \u03c3\u03b5 \u03b1\u03bd\u03c4\u03af\u03b8\u03b5\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b9\u03c2 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03bf\u03c5 \u03c4\u03bf\u03c5 LDL-R, \u03bf\u03b9 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03c0\u03bf\u03c5 \u03b1\u03c6\u03bf\u03c1\u03bf\u03cd\u03bd \u03c4\u03bf \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf \u03c4\u03b7\u03c2 apoB \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03b9\u03ac\u03b6\u03bf\u03c5\u03bd \u03b1\u03c4\u03b5\u03bb\u03ae \u03b4\u03b9\u03b5\u03b9\u03c3\u03b4\u03c5\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03bf\u03b9 \u03c6\u03bf\u03c1\u03b5\u03af\u03c2 \u03c4\u03c9\u03bd \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03c9\u03bd \u03b1\u03c5\u03c4\u03ce\u03bd \u03bd\u03b1 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03bf\u03c5\u03bd \u03ba\u03b1\u03c4\u03ac \u03ba\u03b1\u03bd\u03cc\u03bd\u03b1 \u03b7\u03c0\u03b9\u03cc\u03c4\u03b5\u03c1\u03b7 \u03b4\u03c5\u03c3\u03bb\u03b9\u03c0\u03b9\u03b4\u03b1\u03b9\u03bc\u03af\u03b1 (\u03c7\u03b1\u03bc\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 LDL \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2 \u03ba\u03b1\u03c4\u03ac 20-25%) \u03c3\u03b5 \u03c3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03bf\u03c5\u03c2 \u03c6\u03bf\u03c1\u03b5\u03af\u03c2 \u03c4\u03c9\u03bd \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03c9\u03bd \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03bf\u03c5 \u03c4\u03bf\u03c5 LDL-R \u00a0(11).<\/p>\n<h5 style=\"text-align: justify;\"><b>2.3. \u039c\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03bf\u03c5 \u03c4\u03b7\u03c2 <\/b><b>proprotein <\/b><b>convertase <\/b><b>subtilin\/<\/b><b>kexin <\/b><b>type 9<\/b> <b>PCSK9<\/b><\/h5>\n<p style=\"text-align: justify;\">H proprotein convertase subtilin\/kexin type 9 (PCSK9) \u03b5\u03ba\u03ba\u03c1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03b7\u03c0\u03b1\u03c4\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03c3\u03b4\u03ad\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf\u03bd LDL-R \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c4\u03bf\u03bd \u03ba\u03b1\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03c3\u03bc\u03cc \u03c4\u03bf\u03c5.(12) \u039c\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03c0\u03bf\u03c5 \u03bf\u03b4\u03b7\u03b3\u03bf\u03cd\u03bd \u03c3\u03c4\u03b7\u03bd \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03bf\u03c5 \u03c4\u03b7\u03c2 PCSK9 (\u03c7\u03c1\u03c9\u03bc\u03cc\u03c3\u03c9\u03bc\u03b1 1q34.1-p32) \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03bf\u03cd\u03bd \u03c4\u03b7\u03bd \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7 \u03b4\u03c5\u03c3\u03bb\u03b9\u03c0\u03b9\u03b4\u03b1\u03b9\u03bc\u03af\u03b1\u03c2 \u03b5\u03be\u03b1\u03b9\u03c4\u03af\u03b1\u03c2 \u03c4\u03bf\u03c5 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf\u03c5 \u03ba\u03b1\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03c3\u03bc\u03bf\u03cd \u03c4\u03c9\u03bd LDL-R. \u038c\u03c0\u03c9\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03bf\u03c5 \u03c4\u03bf\u03c5 LDL-R,\u00a0 \u03bf\u03b9 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03bf\u03c5 \u03c4\u03b7\u03c2 PCSK9 \u03c4\u03b1\u03be\u03b9\u03bd\u03bf\u03bc\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 5 \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03c0\u03bf\u03c5 \u03bf\u03b4\u03b7\u03b3\u03bf\u03cd\u03bd \u03c3\u03b5 \u201cnull alleles\u201d, \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03c0\u03bf\u03c5 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03bc\u03b5\u03c4\u03b1\u03c6\u03bf\u03c1\u03ac \u03ae \u03c4\u03b7 \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03ac\u03bb\u03bb\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03bf\u03cd\u03bd \u03c5\u03c0\u03b5\u03c1\u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03bf\u03c5 \u03c4\u03b7\u03c2 (13-15). \u0397 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 \u03c3\u03c4\u03bf \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf \u03c4\u03b7\u03c2 PCSK9 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c3\u03c5\u03bc\u03b2\u03b5\u03af \u03b1\u03b8\u03c1\u03bf\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03bf\u03c5 \u03c4\u03bf\u03c5 LDL-R \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03b7\u03bd \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7 \u03c3\u03bf\u03b2\u03b1\u03c1\u03bf\u03cd \u03b2\u03b1\u03b8\u03bc\u03bf\u03cd \u03b4\u03c5\u03c3\u03bb\u03b9\u03c0\u03b9\u03b4\u03b1\u03b9\u03bc\u03af\u03b1\u03c2 \u03bc\u03b5 \u03bc\u03b9\u03b1 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03c0\u03bf\u03c5 \u03b4\u03b5\u03bd \u03b4\u03b9\u03b1\u03c6\u03ad\u03c1\u03b5\u03b9 \u03b1\u03c0\u03cc \u03b5\u03ba\u03b5\u03af\u03bd\u03b7 \u03c4\u03c9\u03bd \u03c6\u03bf\u03c1\u03ad\u03c9\u03bd \u03c4\u03b7\u03c2 \u03bf\u03bc\u03cc\u03b6\u03c5\u03b3\u03b7\u03c2 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7\u03c2 \u03c4\u03bf\u03c5 LDL-R \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03bf\u03c5 (16).<\/p>\n<h5 style=\"text-align: justify;\"><b>2.4. \u039c\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03bf\u03c5 \u03c4\u03b7\u03c2 \u03c0\u03c1<\/b><b>o\u03c3\u03b1\u03c1\u03bc\u03bf\u03c3\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2 \u03c4\u03bf\u03c5 <\/b><b>LDL-<\/b><b>R 1 (<\/b><b>LDL-<\/b><b>R <\/b><b>Adaptor <\/b><b>Protein 1)<\/b><\/h5>\n<p style=\"text-align: justify;\">\u039c\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03bf\u03c5 \u03c4\u03b7\u03c2 LDL-R Adaptor Protein 1 \u03c0\u03bf\u03c5 \u03b5\u03b4\u03c1\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf \u03c7\u03c1\u03c9\u03bc\u03cc\u03c3\u03c9\u03bc\u03b1 1p36-35 \u03b1\u03bd\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03b5\u03bd\u03b4\u03bf\u03ba\u03cd\u03c4\u03c4\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bc\u03c0\u03bb\u03ad\u03b3\u03bc\u03b1\u03c4\u03bf\u03c2 \u00ab\u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1\/LDL\u00bb \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03cc\u03bb\u03bf\u03b9 \u03bf\u03b9 LDL-R \u03bd\u03b1 \u03c3\u03c5\u03c3\u03c3\u03c9\u03c1\u03b5\u03cd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03c6\u03ac\u03bd\u03b5\u03b9\u03b1 \u03c4\u03bf\u03c5 \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03bf\u03c5 (17). \u0397 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 \u03bc\u03b5\u03c4\u03b1\u03b2\u03b9\u03b2\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03b1\u03c5\u03c4\u03bf\u03c3\u03c9\u03bc\u03b9\u03ba\u03cc \u03c5\u03c0\u03bf\u03bb\u03b5\u03b9\u03c0\u03cc\u03bc\u03b5\u03bd\u03bf \u03c4\u03cd\u03c0\u03bf \u03ba\u03bb\u03b7\u03c1\u03bf\u03bd\u03bf\u03bc\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03b5\u03bd\u03ce \u03b5\u03af\u03bd\u03b1\u03b9 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c3\u03c0\u03ac\u03bd\u03b9\u03b1 (18). \u0397 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03b9\u03ac\u03b6\u03b5\u03b9 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b7 \u03c0\u03bf\u03b9\u03ba\u03b9\u03bb\u03af\u03b1 \u03b1\u03ba\u03cc\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03b1\u03bd\u03ac\u03bc\u03b5\u03c3\u03b1 \u03c3\u03b5 \u03bc\u03ad\u03bb\u03b7 \u03c4\u03b7\u03c2 \u03af\u03b4\u03b9\u03b1\u03c2 \u03bf\u03b9\u03ba\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1\u03c2 (19). \u0397 \u03b4\u03c5\u03c3\u03bb\u03b9\u03c0\u03b9\u03b4\u03b1\u03b9\u03bc\u03af\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03b7\u03c0\u03b9\u03cc\u03c4\u03b5\u03c1\u03b7 \u03ba\u03b1\u03b9 \u03ad\u03c7\u03b5\u03b9 \u03ba\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03b1\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7 \u03c3\u03c4\u03b9\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b1\u03c1\u03b5\u03bc\u03b2\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c3\u03b5 \u03c3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03ba\u03bb\u03b1\u03c3\u03b9\u03ba\u03ae \u03bc\u03bf\u03c1\u03c6\u03ae FH \u03c0\u03bf\u03c5 \u03bc\u03b5\u03c4\u03b1\u03b2\u03b9\u03b2\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03b1\u03c5\u03c4\u03bf\u03c3\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc \u03b5\u03c0\u03b9\u03ba\u03c1\u03b1\u03c4\u03bf\u03cd\u03bd\u03c4\u03b1 \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03ae\u03c1\u03b1 (20). \u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03ba\u03b1\u03b8\u03ce\u03c2 \u03bf \u03ba\u03b1\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03c3\u03bc\u03cc\u03c2 \u03c4\u03b7\u03c2 LDL \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bc\u03b5\u03b9\u03c9\u03b8\u03b5\u03af \u03ad\u03c9\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03bf \u03ad\u03bd\u03b1 \u03c4\u03c1\u03af\u03c4\u03bf \u03c4\u03bf\u03c5 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03bf\u03cd, \u03bf \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03b5\u03b9 \u03c4\u03bf\u03bd \u03af\u03b4\u03b9\u03bf \u03c6\u03b1\u03b9\u03bd\u03cc\u03c4\u03c5\u03c0\u03bf \u03bc\u03b5 \u03ad\u03bd\u03b1\u03bd \u03bf\u03bc\u03bf\u03b6\u03c5\u03b3\u03ce\u03c4\u03b7 \u03c4\u03b7\u03c2 LDL-R \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7\u03c2 (20, 21).<\/p>\n<h4 style=\"text-align: justify;\"><b>3. \u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1<\/b><\/h4>\n<p style=\"text-align: justify;\">\u03a7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03cc \u03b3\u03bd\u03ce\u03c1\u03b9\u03c3\u03bc\u03b1 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 \u03c4\u03c9\u03bd \u03c4\u03b5\u03bd\u03cc\u03bd\u03c4\u03b9\u03c9\u03bd \u03be\u03b1\u03bd\u03b8\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd. \u03a0\u03c1\u03cc\u03ba\u03b5\u03b9\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03bb\u03b5\u03c5\u03ba\u03c9\u03c0\u03ad\u03c2 \u03bf\u03b6\u03ce\u03b4\u03b5\u03b9\u03c2 \u03b4\u03b9\u03bf\u03b3\u03ba\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c0\u03bf\u03c5 \u03b5\u03bd\u03c4\u03bf\u03c0\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c4\u03c5\u03c0\u03b9\u03ba\u03ac \u03c3\u03c4\u03bf\u03bd \u03b1\u03c7\u03af\u03bb\u03bb\u03b5\u03b9\u03bf \u03c4\u03ad\u03bd\u03bf\u03bd\u03c4\u03b1 \u03ae \u03c3\u03c4\u03b9\u03c2 \u03b5\u03ba\u03c4\u03b1\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b5\u03c0\u03b9\u03c6\u03ac\u03bd\u03b5\u03b9\u03b5\u03c2 \u03c4\u03bf\u03c5 \u03b1\u03b3\u03ba\u03ce\u03bd\u03b1 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03c1\u03b1\u03c7\u03b9\u03b1\u03af\u03b1 \u03b5\u03c0\u03b9\u03c6\u03ac\u03bd\u03b5\u03b9\u03b1 \u03c4\u03c9\u03bd \u03ac\u03ba\u03c1\u03c9\u03bd \u03c7\u03b5\u03b9\u03c1\u03ce\u03bd. \u039f\u03c6\u03b5\u03af\u03bb\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03c3\u03c5\u03c3\u03c3\u03ce\u03c1\u03b5\u03c5\u03c3\u03b7 \u03b9\u03bd\u03ce\u03bd \u03ba\u03bf\u03bb\u03bb\u03b1\u03b3\u03cc\u03bd\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03b1\u03c6\u03c1\u03c9\u03b4\u03ce\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c0\u03bf\u03c5 \u03c0\u03b5\u03c1\u03b9\u03ad\u03c7\u03bf\u03c5\u03bd \u03ac\u03c6\u03b8\u03bf\u03bd\u03b1 \u03c3\u03c4\u03b1\u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 \u03bb\u03af\u03c0\u03bf\u03c5\u03c2 \u03c3\u03c4\u03bf \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03cc\u03c0\u03bb\u03b1\u03c3\u03bc\u03ac \u03c4\u03bf\u03c5\u03c2<i>. <\/i>\u03a3\u03c4\u03bf\u03c5\u03c2 \u03bf\u03bc\u03bf\u03b6\u03c5\u03b3\u03ce\u03c4\u03b5\u03c2 \u03c4\u03b1 \u03c4\u03b5\u03bd\u03cc\u03bd\u03c4\u03b9\u03b1 \u03be\u03b1\u03bd\u03b8\u03ce\u03bc\u03b1\u03c4\u03b1 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03ae\u03b4\u03b7 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03c0\u03b1\u03b9\u03b4\u03b9\u03ba\u03ae \u03b7\u03bb\u03b9\u03ba\u03af\u03b1, \u03b5\u03bd\u03ce \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b5\u03c4\u03b5\u03c1\u03bf\u03b6\u03c5\u03b3\u03ce\u03c4\u03b5\u03c2 \u03c3\u03c4\u03b7\u03bd \u03b7\u03bb\u03b9\u03ba\u03af\u03b1 \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 \u03c4\u03c9\u03bd 20 \u03b5\u03c4\u03ce\u03bd. \u0397 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03ac \u03c4\u03bf\u03c5\u03c2 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03c0\u03ac\u03c1\u03bf\u03b4\u03bf \u03c4\u03bf\u03c5 \u03c7\u03c1\u03cc\u03bd\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b7\u03b8\u03bf\u03cd\u03bd \u03ad\u03c9\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03bf 75-86% \u03c4\u03c9\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd. \u03a4\u03b1 \u03c4\u03b5\u03bd\u03cc\u03bd\u03c4\u03b9\u03b1 \u03be\u03b1\u03bd\u03b8\u03ce\u03bc\u03b1\u03c4\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5 \u03b1\u03bb\u03bb\u03ac \u03cc\u03c7\u03b9 \u03c0\u03b1\u03b8\u03bf\u03b3\u03bd\u03c9\u03bc\u03bf\u03bd\u03b9\u03ba\u03ac. \u0386\u03bb\u03bb\u03b1 \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03b3\u03bd\u03c9\u03c1\u03af\u03c3\u03bc\u03b1\u03c4\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03bf\u03cd\u03bd \u03c4\u03b1 \u03be\u03b1\u03bd\u03b8\u03b5\u03bb\u03ac\u03c3\u03bc\u03b1\u03c4\u03b1 (\u03b5\u03bd\u03b1\u03c0\u03cc\u03b8\u03b5\u03c3\u03b7 \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2 \u03c3\u03c4\u03b1 \u03b2\u03bb\u03ad\u03c6\u03b1\u03c1\u03b1) \u03ba\u03b1\u03b9 \u03c4\u03bf \u03b3\u03b5\u03c1\u03bf\u03bd\u03c4\u03cc\u03c4\u03bf\u03be\u03bf (\u03b5\u03bd\u03b1\u03c0\u03cc\u03b8\u03b5\u03c3\u03b7 \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2 \u03c3\u03c4\u03bf\u03bd \u03ba\u03b5\u03c1\u03b1\u03c4\u03bf\u03b5\u03b9\u03b4\u03ae). \u03a4\u03b1 \u03be\u03b1\u03bd\u03b8\u03b5\u03bb\u03ac\u03c3\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03bf \u03b3\u03b5\u03c1\u03bf\u03bd\u03c4\u03cc\u03c4\u03bf\u03be\u03bf \u03b4\u03b5\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03bf\u03cd\u03bd \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03b3\u03bd\u03c9\u03c1\u03af\u03c3\u03bc\u03b1\u03c4\u03b1 \u03c4\u03b7\u03c2 FH, \u03b1\u03bb\u03bb\u03ac \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03b1\u03bd\u03b5\u03c5\u03c1\u03b5\u03b8\u03bf\u03cd\u03bd \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03ac\u03bb\u03bb\u03b5\u03c2 \u03b4\u03c5\u03c3\u03bb\u03b9\u03c0\u03b9\u03b4\u03b1\u03b9\u03bc\u03af\u03b5\u03c2 \u03ae \u03b1\u03ba\u03cc\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03bd\u03bf\u03c1\u03bc\u03bf\u03bb\u03b9\u03c0\u03b9\u03b4\u03b1\u03b9\u03bc\u03b9\u03ba\u03ac \u03ac\u03c4\u03bf\u03bc\u03b1 (22).<\/p>\n<p style=\"text-align: justify;\">\u0397 \u03ad\u03b3\u03ba\u03b1\u03b9\u03c1\u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03c9\u03c2 \u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03ce\u03c0\u03b9\u03c3\u03b7 \u03c4\u03b7\u03c2 FH \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf\u03c5\u03c3\u03b9\u03ce\u03b4\u03b5\u03b9\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ce\u03bd \u03b5\u03c0\u03b9\u03c0\u03bb\u03bf\u03ba\u03ce\u03bd \u03c0\u03bf\u03c5 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7 \u03bd\u03cc\u03c3\u03bf. \u0391\u03bd\u03b1\u03bc\u03c6\u03b9\u03c3\u03b2\u03ae\u03c4\u03b7\u03c4\u03b1 \u03bf \u03b3\u03bf\u03bd\u03b9\u03b4\u03b9\u03b1\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf \u03c7\u03c1\u03c5\u03c3\u03cc\u03c2 \u03ba\u03b1\u03bd\u03cc\u03bd\u03b1\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 FH. \u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03c3\u03c4\u03b9\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c0\u03bf\u03c5 \u03b1\u03c5\u03c4\u03cc \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03c6\u03b9\u03ba\u03c4\u03cc, \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b5\u03c5\u03c1\u03ad\u03c9\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03ba\u03c1\u03b9\u03c4\u03ae\u03c1\u03b9\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5, \u03cc\u03c0\u03c9\u03c2 \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03ac\u03c6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03c3\u03c5\u03bd\u03ad\u03c7\u03b5\u03b9\u03b1.<\/p>\n<h5 style=\"text-align: justify;\"><b>3.1. \u039a\u03c1\u03b9\u03c4\u03ae\u03c1\u03b9\u03b1 \u03ba\u03b1\u03c4\u03ac Simon Broome<\/b><\/h5>\n<table style=\"width: 100%;\" border=\"0\" cellspacing=\"3\" cellpadding=\"3\" align=\"center\">\n<tbody>\n<tr style=\"background-color: #385a72;\">\n<td colspan=\"4\"><\/td>\n<\/tr>\n<tr>\n<td rowspan=\"3\">\u039f\u03bb\u03b9\u03ba\u03ae \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7 &gt;290mg\/dL \u03c3\u03b5 \u03b5\u03bd\u03ae\u03bb\u03b9\u03ba\u03b5\u03c2 \u03ae\u00a0 &gt;260 mg\/dL \u03c3\u03b5 \u03c0\u03b1\u03b9\u03b4\u03b9\u03ac LDL \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7 &gt;190 \u03c3\u03b5 \u03b5\u03bd\u03ae\u03bb\u03b9\u03ba\u03b5\u03c2 \u03ae\u00a0 &gt;155 mg\/dL \u03c3\u03b5 \u03c0\u03b1\u03b9\u03b4\u03b9\u03ac<\/td>\n<td rowspan=\"3\">KAI<\/td>\n<td>\u0393\u03bf\u03bd\u03b9\u03b4\u03b9\u03b1\u03ba\u03ae \u039c\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7<\/td>\n<td>\u0392\u03ad\u03b2\u03b1\u03b9\u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7<\/td>\n<\/tr>\n<tr>\n<td>\u03a4\u03b5\u03bd\u03cc\u03bd\u03c4\u03b9\u03b1 \u03be\u03b1\u03bd\u03b8\u03ce\u03bc\u03b1\u03c4\u03b1 \u03c3\u03c4\u03bf\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae \u03ae \u03c3\u03b5 \u03c3\u03c5\u03b3\u03b3\u03b5\u03bd\u03ae \u03b1\u0384\u03ae \u03b2\u0384\u03b2\u03b1\u03b8\u03bc\u03bf\u03cd<\/td>\n<td>\u03a0\u03b9\u03b8\u03b1\u03bd\u03ae \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7<\/td>\n<\/tr>\n<tr>\n<td>\u0399\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc \u03b5\u03bc\u03c6\u03c1\u03ac\u03b3\u03bc\u03b1\u03c4\u03bf\u03c2 \u03bc\u03c5\u03bf\u03ba\u03b1\u03c1\u03b4\u03af\u03bf\u03c5 \u03c3\u03b5 \u03c3\u03c5\u03b3\u03b3\u03b5\u03bd\u03ae \u03b2\u0384 \u03b2\u03b1\u03b8\u03bc\u03bf\u03cd \u03ba\u03ac\u03c4\u03c9 \u03c4\u03c9\u03bd 50 \u03b5\u03c4\u03ce\u03bd \u03ae \u03c3\u03b5 \u03c3\u03c5\u03b3\u03b3\u03b5\u03bd\u03ae \u03b1\u0384 \u03b2\u03b1\u03b8\u03bc\u03bf\u03cd \u03ba\u03ac\u03c4\u03c9 \u03c4\u03c9\u03bd 60 \u03b5\u03c4\u03ce\u03bd \u03ae \u03bf\u03bb\u03b9\u03ba\u03ae \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7 &gt;290 mg\/dL \u03c3\u03b5 \u03c3\u03c5\u03b3\u03b3\u03b5\u03bd\u03ae \u03b1\u0384\u03ae \u03b2\u0384 \u03b2\u03b1\u03b8\u03bc\u03bf\u03cd<\/td>\n<td>\u0395\u03bd\u03b4\u03b5\u03c7\u03cc\u03bc\u03b5\u03bd\u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p style=\"text-align: justify;\">\u0391\u03be\u03af\u03b6\u03b5\u03b9 \u03bd\u03b1 \u03c3\u03b7\u03bc\u03b5\u03b9\u03c9\u03b8\u03b5\u03af \u03cc\u03c4\u03b9 17-33% \u03c4\u03c9\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03bc\u03b5 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 FH \u03c3\u03cd\u03bc\u03c6\u03c9\u03bd\u03b1 \u03bc\u03b5 \u03c4\u03b1 \u03ba\u03c1\u03b9\u03c4\u03ae\u03c1\u03b9\u03b1 Simon Broome \u03b4\u03b5 \u03c6\u03ad\u03c1\u03bf\u03c5\u03bd \u03ba\u03b1\u03bc\u03af\u03b1 \u03b3\u03bd\u03c9\u03c3\u03c4\u03ae \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7.<\/p>\n<h5 style=\"text-align: justify;\"><b>3.2. \u039a\u03c1\u03b9\u03c4\u03ae\u03c1\u03b9\u03b1 \u03ba\u03b1\u03c4\u03ac \u00a0Dutch<\/b><\/h5>\n<p style=\"text-align: justify;\">\u03a3\u03c4\u03b1 \u03ba\u03c1\u03b9\u03c4\u03ae\u03c1\u03b9\u03b1 \u03c4\u03bf\u03c5 Dutch \u03b2\u03b1\u03b8\u03bc\u03bf\u03bb\u03bf\u03b3\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c4\u03b1 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03ba\u03b1\u03b9 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ac \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03c4\u03bf\u03c5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03c3\u03c5\u03bd\u03ad\u03c7\u03b5\u03b9\u03b1 \u03c0\u03c1\u03bf\u03c3\u03c4\u03af\u03b8\u03b5\u03bd\u03c4\u03b1\u03b9. \u0391\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03bf \u03cd\u03c8\u03bf\u03c2 \u03c4\u03b7\u03c2 \u03b2\u03b1\u03b8\u03bc\u03bf\u03bb\u03bf\u03b3\u03af\u03b1\u03c2 \u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b1\u03c6\u03ae\u03c2 (\u22658 \u03b2\u03b1\u03b8\u03bc\u03bf\u03af), \u03c0\u03b9\u03b8\u03b1\u03bd\u03ae (6-7 \u03b2\u03b1\u03b8\u03bc\u03bf\u03af) \u03ae \u03b5\u03bd\u03b4\u03b5\u03c7\u03cc\u03bc\u03b5\u03bd\u03b7 (3-5 \u03b2\u03b1\u03b8\u03bc\u03bf\u03af), \u03cc\u03c0\u03c9\u03c2 \u03b4\u03b9\u03b1\u03ba\u03c1\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c0\u03b1\u03c1\u03b1\u03ba\u03ac\u03c4\u03c9:<\/p>\n<table style=\"width: 100%;\" border=\"0\" cellspacing=\"3\" cellpadding=\"3\" align=\"center\">\n<tbody>\n<tr style=\"background-color: #385a72;\">\n<td valign=\"top\">\n<p align=\"center\"><span style=\"color: #ffffff;\"><b>\u0392\u03b1\u03b8\u03bc\u03bf\u03af<\/b><\/span><\/p>\n<\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: left;\">\n<p align=\"center\">1<\/p>\n<\/td>\n<td>1<sup>\u03bf\u03c5<\/sup> \u03b2\u03b1\u03b8\u03bc\u03bf\u03cd \u03c3\u03c5\u03b3\u03b3\u03b5\u03bd\u03ae\u03c2 \u03bc\u03b5 \u03c0\u03c1\u03ce\u03b9\u03bc\u03b7 \u03c3\u03c4\u03b5\u03c6\u03b1\u03bd\u03b9\u03b1\u03af\u03b1 \u03bd\u03cc\u03c3\u03bf LDL \u03ae \u03bc\u03b5 LDL \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7 &gt;95\u03b7 \u03b5\u03ba\u03b1\u03c4\u03bf\u03c3\u03c4\u03b9\u03b1\u03af\u03b1 \u03b8\u03ad\u03c3\u03b7 \u03c3\u03c4\u03b7\u03bd \u03c0\u03b1\u03b9\u03b4\u03b9\u03ba\u03ae \u03b7\u03bb\u03b9\u03ba\u03af\u03b1\u03ae\u0384\u0391\u03c4\u03bf\u03bc\u03b9\u03ba\u03cc \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc\u00a0 \u03c0\u03c1\u03ce\u03b9\u03bc\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5 \u03c4\u03c9\u03bd \u03c0\u03b5\u03c1\u03b9\u03c6\u03b5\u03c1\u03b9\u03ba\u03ce\u03bd \u03ae \u03b5\u03b3\u03ba\u03b5\u03c6\u03b1\u03bb\u03b9\u03ba\u03ce\u03bd \u03b1\u03b3\u03b3\u03b5\u03af\u03c9\u03bd<br \/>\n\u03ae<br \/>\n\u03a3\u03c5\u03b3\u03ba\u03ad\u03bd\u03c4\u03c1\u03c9\u03c3\u03b7 LDL \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2 155-190mg\/dl<\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: left;\">\n<p align=\"center\">2<\/p>\n<\/td>\n<td>\u039e\u03b1\u03bd\u03b8\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ae \u03c0\u03c1\u03ce\u03b9\u03bc\u03bf \u03b3\u03b5\u03c1\u03bf\u03bd\u03c4\u03cc\u03c4\u03bf\u03be\u03bf \u03c3\u03b5 \u03c3\u03c5\u03b3\u03b3\u03b5\u03bd\u03ae \u03b1\u0384 \u03b2\u03b1\u03b8\u03bc\u03bf\u03cd\u03ae\u03841<sup>\u03bf\u03c5<\/sup> \u03b2\u03b1\u03b8\u03bc\u03bf\u03cd\u00a0 \u03c3\u03c5\u03b3\u03b3\u03b5\u03bd\u03ae\u03c2 \u03bc\u03b5 \u03c3\u03c5\u03b3\u03ba\u03ad\u03bd\u03c4\u03c1\u03c9\u03c3\u03b7 LDL \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2 &gt;95\u03b7 \u03b5\u03ba\u03b1\u03c4\u03bf\u03c3\u03c4\u03b9\u03b1\u03af\u03b1 \u03b8\u03ad\u03c3\u03b7 \u03c3\u03c4\u03b7\u03bd \u03c0\u03b1\u03b9\u03b4\u03b9\u03ba\u03ae \u03b7\u03bb\u03b9\u03ba\u03af\u03b1 \u03ae \u03bc\u03b5 \u03c0\u03c1\u03ce\u03b9\u03bc\u03b7 \u03c3\u03c4\u03b5\u03c6\u03b1\u03bd\u03b9\u03b1\u03af\u03b1 \u03bd\u03cc\u03c3\u03bf<\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: left;\" valign=\"top\">\n<p align=\"center\">3<\/p>\n<\/td>\n<td>\u03a3\u03c5\u03b3\u03ba\u03ad\u03bd\u03c4\u03c1\u03c9\u03c3\u03b7 LDL \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2 190-249 mg\/dL<\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: left;\">\n<p align=\"center\">4<\/p>\n<\/td>\n<td>\u0393\u03b5\u03c1\u03bf\u03bd\u03c4\u03cc\u03c4\u03bf\u03be\u03bf \u00a0\u03c3\u03b5 \u03b7\u03bb\u03b9\u03ba\u03af\u03b1 &lt; 45 \u03ad\u03c4\u03b7<\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: left;\">\n<p align=\"center\">5<\/p>\n<\/td>\n<td>\u03a3\u03c5\u03b3\u03ba\u03ad\u03bd\u03c4\u03c1\u03c9\u03c3\u03b7 LDL \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2 250-329 mg\/dL<\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: left;\">\n<p align=\"center\">6<\/p>\n<\/td>\n<td>\u03a0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 \u03c4\u03b5\u03bd\u03cc\u03bd\u03c4\u03b9\u03bf\u03c5 \u03be\u03b1\u03bd\u03b8\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2<\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: left;\">\n<p align=\"center\">8<\/p>\n<\/td>\n<td>\u03a3\u03c5\u03b3\u03ba\u03ad\u03bd\u03c4\u03c1\u03c9\u03c3\u03b7 LDL \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2 &gt;330 mg\/dL\u03ae\u039c\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03bf\u03c5 \u03c4\u03bf\u03c5 LDL-R<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p style=\"text-align: justify;\">\u03a4\u03b1 \u03c0\u03b1\u03c1\u03b1\u03c0\u03ac\u03bd\u03c9 \u03ba\u03c1\u03b9\u03c4\u03ae\u03c1\u03b9\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03bf\u03cd\u03bd \u03c7\u03c1\u03ae\u03c3\u03b9\u03bc\u03bf \u03b5\u03c1\u03b3\u03b1\u03bb\u03b5\u03af\u03bf \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u03c0\u03c1\u03bf\u03c3\u03ad\u03b3\u03b3\u03b9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c3\u03c5\u03b3\u03b3\u03b5\u03bd\u03ce\u03bd \u03b1\u03c4\u03cc\u03bc\u03c9\u03bd \u03bc\u03b5 FH. \u03a0\u03b1\u03c1\u03ac \u03c4\u03bf \u03b3\u03b5\u03b3\u03bf\u03bd\u03cc\u03c2 \u03cc\u03c4\u03b9 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03bf\u03bb\u03cd \u03b1\u03ba\u03c1\u03b9\u03b2\u03ae \u03cc\u03c3\u03bf\u03bd \u03b1\u03c6\u03bf\u03c1\u03ac \u03c4\u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5 \u03c3\u03c4\u03bf \u03b3\u03b5\u03bd\u03b9\u03ba\u03cc \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03cc, \u03c4\u03bf \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc \u03ba\u03cc\u03c3\u03c4\u03bf\u03c2 \u03c4\u03b7\u03c2 \u03b5\u03c6\u03b1\u03c1\u03bc\u03bf\u03b3\u03ae\u03c2 \u03c4\u03c9\u03bd \u03ba\u03c1\u03b9\u03c4\u03b7\u03c1\u03af\u03c9\u03bd \u03b1\u03c5\u03c4\u03ce\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03c0\u03bb\u03b5\u03bf\u03bd\u03ad\u03ba\u03c4\u03b7\u03bc\u03b1 \u03c3\u03b5 \u03c3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03b3\u03bf\u03bd\u03b9\u03b4\u03b9\u03b1\u03ba\u03cc \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf.<\/p>\n<h4 style=\"text-align: justify;\"><b>4. \u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1<\/b><\/h4>\n<h5 style=\"text-align: justify;\"><b>4.1. \u03a3\u03c4\u03cc\u03c7\u03bf\u03b9 \u03c4\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2<\/b><\/h5>\n<p style=\"text-align: justify;\">\u039f\u03b9 \u03b1\u03bc\u03b5\u03c1\u03b9\u03ba\u03b1\u03bd\u03b9\u03ba\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03bf\u03b9 \u03b2\u03c1\u03b5\u03c4\u03b1\u03bd\u03b9\u03ba\u03ad\u03c2 \u03ba\u03b1\u03c4\u03b5\u03c5\u03b8\u03c5\u03bd\u03c4\u03ae\u03c1\u03b9\u03b5\u03c2 \u03bf\u03b4\u03b7\u03b3\u03af\u03b5\u03c2 (US National Lipid Association \u03ba\u03b1\u03b9 NICE, \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03bf\u03b9\u03c7\u03b1) \u03c3\u03c5\u03c3\u03c4\u03ae\u03bd\u03bf\u03c5\u03bd \u03c4\u03b7 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b5\u03c0\u03b9\u03c0\u03ad\u03b4\u03c9\u03bd \u03c4\u03b7\u03c2 LDL \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2 &gt;50% \u03c3\u03b5 \u03c3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c0\u03c1\u03b9\u03bd \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03ad\u03bd\u03b1\u03c1\u03be\u03b7 \u03c4\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 (23, 24). \u039f\u03b9 \u03ba\u03b1\u03bd\u03b1\u03b4\u03b9\u03ba\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03bf\u03b9 \u03b5\u03c5\u03c1\u03c9\u03c0\u03b1\u03ca\u03ba\u03ad\u03c2 \u03bf\u03b4\u03b7\u03b3\u03af\u03b5\u03c2 \u03c3\u03c5\u03bd\u03b9\u03c3\u03c4\u03bf\u03cd\u03bd \u03c4\u03b7 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b5\u03c0\u03b9\u03c0\u03ad\u03b4\u03c9\u03bd \u03c4\u03b7\u03c2 LDL \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2 \u03bc\u03b5 \u03b2\u03ac\u03c3\u03b7 \u03c4\u03bf \u03c3\u03cd\u03c3\u03c4\u03b7\u03bc\u03b1 SCORE \u03c4\u03bf\u03c5 \u03c5\u03c0\u03bf\u03bb\u03bf\u03b3\u03b9\u03c3\u03bc\u03bf\u03cd \u03c4\u03bf\u03c5 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7\u03c2 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ae\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5 (25-27):<\/p>\n<ul style=\"text-align: justify;\">\n<li>&lt;115 mg\/dL (3,0 mmol\/L) \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03bc\u03ad\u03c4\u03c1\u03b9\u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7\u03c2 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ae\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5,<\/li>\n<li>&lt;100 mg\/dL (2,5 mmol\/L) \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03c5\u03c8\u03b7\u03bb\u03cc \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7\u03c2 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ae\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5,<\/li>\n<li>&lt;70 mg\/dL (1,8 mmol\/L) \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03c0\u03bf\u03bb\u03cd \u03c5\u03c8\u03b7\u03bb\u03cc \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7\u03c2 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ae\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5.<\/li>\n<\/ul>\n<p style=\"text-align: justify;\">\u03a3\u03c4\u03b9\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c0\u03bf\u03c5 \u03bf\u03b9 \u03c0\u03c1\u03bf\u03c4\u03b5\u03b9\u03bd\u03cc\u03bc\u03b5\u03bd\u03bf\u03b9 \u03c3\u03c4\u03cc\u03c7\u03bf\u03b9 \u03b4\u03b5\u03bd \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03b5\u03c0\u03b9\u03c4\u03b5\u03c5\u03c7\u03b8\u03bf\u03cd\u03bd \u03bb\u03cc\u03b3\u03c9 \u03c4\u03c9\u03bd \u03c0\u03bf\u03bb\u03cd \u03c5\u03c8\u03b7\u03bb\u03ce\u03bd \u03b1\u03c1\u03c7\u03b9\u03ba\u03ce\u03bd \u03b5\u03c0\u03b9\u03c0\u03ad\u03b4\u03c9\u03bd \u03c4\u03b7\u03c2 \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2, \u03c3\u03c5\u03bd\u03b9\u03c3\u03c4\u03ac\u03c4\u03b1\u03b9 \u03b7 \u03bc\u03ad\u03b3\u03b9\u03c3\u03c4\u03b7 \u03b4\u03c5\u03bd\u03b1\u03c4\u03ae \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b5\u03c0\u03b9\u03c0\u03ad\u03b4\u03c9\u03bd \u03c4\u03b7\u03c2 LDL \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2 \u03c0\u03bf\u03c5 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03c0\u03b9\u03c4\u03b5\u03c5\u03c7\u03b8\u03b5\u03af \u03c7\u03c9\u03c1\u03af\u03c2 \u03c4\u03b7\u03bd \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7 \u03b1\u03bd\u03b5\u03c0\u03b9\u03b8\u03cd\u03bc\u03b7\u03c4\u03c9\u03bd \u03b5\u03bd\u03b5\u03c1\u03b3\u03b5\u03b9\u03ce\u03bd (25).<\/p>\n<h5 style=\"text-align: justify;\"><b>4.2. \u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03b1\u03b3\u03c9\u03b3\u03ae<\/b><\/h5>\n<p style=\"text-align: justify;\">\u0397 \u03c5\u03b9\u03bf\u03b8\u03ad\u03c4\u03b7\u03c3\u03b7 \u03c5\u03b3\u03b9\u03b5\u03b9\u03bd\u03bf\u03b4\u03b9\u03b1\u03b9\u03c4\u03b7\u03c4\u03b9\u03ba\u03ce\u03bd \u03bc\u03ad\u03c4\u03c1\u03c9\u03bd \u03c3\u03c5\u03bd\u03b9\u03c3\u03c4\u03ac\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03cc\u03bb\u03b5\u03c2 \u03c4\u03b9\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2. \u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03c4\u03bf \u03cc\u03c6\u03b5\u03bb\u03bf\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03bc\u03ad\u03c4\u03c1\u03b1 \u03c4\u03b7\u03c2 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ae\u03c2 \u03c4\u03bf\u03c5 \u03c4\u03c1\u03cc\u03c0\u03bf\u03c5 \u03b6\u03c9\u03ae\u03c2 \u03ba\u03b1\u03b9 \u03b4\u03b9\u03b1\u03c4\u03c1\u03b1\u03c6\u03ae\u03c2 \u03b4\u03b5\u03bd \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03b7\u03c2 \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 FH. \u0397 \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03c0\u03c1\u03bf\u03c3\u03ad\u03b3\u03b3\u03b9\u03c3\u03b7 \u03c4\u03b7\u03c2 FH \u03ba\u03b1\u03c4\u03ac \u03ba\u03cd\u03c1\u03b9\u03bf \u03bb\u03cc\u03b3\u03bf \u03c3\u03c4\u03bf\u03c7\u03b5\u03cd\u03b5\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03b7\u03c2 \u03b5\u03bd\u03b4\u03bf\u03b3\u03b5\u03bd\u03bf\u03cd\u03c2 \u03b7\u03c0\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c3\u03cd\u03bd\u03b8\u03b5\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2 \u03ba\u03b1\u03b8\u03ce\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03b7\u03c2 \u03b5\u03bd\u03c4\u03b5\u03c1\u03b9\u03ba\u03ae\u03c2 \u03c4\u03b7\u03c2 \u03b1\u03c0\u03bf\u03c1\u03c1\u03cc\u03c6\u03b7\u03c3\u03ae\u03c2 (28).<\/p>\n<h6 style=\"text-align: justify;\"><b>4.2.1. \u03a3\u03c4\u03b1\u03c4\u03af\u03bd\u03b5\u03c2<\/b><\/h6>\n<p style=\"text-align: justify;\">\u039f\u03b9 \u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b5\u03c2 a\u03c0\u03bf\u03c4\u03b5\u03bb\u03bf\u03cd\u03bd \u03c4\u03bf\u03bd \u03b1\u03ba\u03c1\u03bf\u03b3\u03c9\u03bd\u03b9\u03b1\u03af\u03bf \u03bb\u03af\u03b8\u03bf \u03c3\u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c4\u03b7\u03c2 FH. \u03a4\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 \u03b1\u03c5\u03c4\u03ac \u03b1\u03bd\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03c5\u03bd \u03c4\u03bf \u03ad\u03bd\u03b6\u03c5\u03bc\u03bf \u03b1\u03bd\u03b1\u03b3\u03c9\u03b3\u03ac\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c5\u03b4\u03c1\u03bf\u03be\u03c5-\u03bc\u03ad\u03b8\u03c5\u03bb\u03bf-\u03b3\u03bb\u03bf\u03c5\u03c4\u03ac\u03c1\u03c5\u03bb\u03bf-\u03c3\u03c5\u03bd\u03ad\u03bd\u03b6\u03c5\u03bc\u03bf\u03c5 A (HMG-CoA) \u03c0\u03bf\u03c5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03b1\u03c1\u03b1\u03af\u03c4\u03b7\u03c4\u03bf \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03c3\u03cd\u03bd\u03b8\u03b5\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2 \u03c3\u03c4\u03b1 \u03b7\u03c0\u03b1\u03c4\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1. \u0397 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03bf\u03cd\u03bc\u03b5\u03bd\u03b7 \u03ad\u03bd\u03b4\u03b5\u03b9\u03b1 \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2 \u03c3\u03c4\u03bf \u03b5\u03c3\u03c9\u03c4\u03b5\u03c1\u03b9\u03ba\u03cc \u03c4\u03c9\u03bd \u03b7\u03c0\u03b1\u03c4\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af \u03b1\u03bd\u03c4\u03b9\u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ae \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd LDL-R \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03c6\u03ac\u03bd\u03b5\u03b9\u03b1 \u03c4\u03bf\u03c5 \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03bf\u03c5 \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03b7\u03bd \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03c0\u03bf\u03bc\u03ac\u03ba\u03c1\u03c5\u03bd\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 LDL \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf \u03c0\u03bb\u03ac\u03c3\u03bc\u03b1 \u03ba\u03b1\u03c4\u03ac \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 30-60% (28).<\/p>\n<h6 style=\"text-align: justify;\"><b>4.2.2. \u03a1\u03b7\u03c4\u03af\u03bd\u03b5\u03c2 \u03b4\u03ad\u03c3\u03bc\u03b5\u03c5\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd \u03c7\u03bf\u03bb\u03b9\u03ba\u03ce\u03bd \u03b1\u03bb\u03ac\u03c4\u03c9\u03bd<\/b><\/h6>\n<p style=\"text-align: justify;\">\u039f\u03b9 \u03c1\u03b7\u03c4\u03af\u03bd\u03b5\u03c2 \u03b4\u03c1\u03bf\u03c5\u03bd \u03c3\u03c4\u03bf \u03ad\u03bd\u03c4\u03b5\u03c1\u03bf, \u03cc\u03c0\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03b4\u03b7\u03bc\u03b9\u03bf\u03c5\u03c1\u03b3\u03bf\u03cd\u03bd \u03c3\u03cd\u03bc\u03c0\u03bb\u03bf\u03ba\u03b1 \u03bc\u03b5 \u03c4\u03b1 \u03c7\u03bf\u03bb\u03b9\u03ba\u03ac \u03ac\u03bb\u03b1\u03c4\u03b1, \u03b1\u03bd\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7\u03bd \u03b5\u03c0\u03b1\u03bd\u03b1\u03c1\u03c1\u03cc\u03c6\u03b7\u03c3\u03ae \u03c4\u03bf\u03c5\u03c2. \u0397 \u03b4\u03b9\u03b1\u03ba\u03bf\u03c0\u03ae \u03c4\u03bf\u03c5 \u03b5\u03bd\u03c4\u03b5\u03c1\u03bf\u03b7\u03c0\u03b1\u03c4\u03b9\u03ba\u03bf\u03cd \u03ba\u03cd\u03ba\u03bb\u03bf\u03c5 \u03c4\u03c9\u03bd \u03c7\u03bf\u03bb\u03b9\u03ba\u03ce\u03bd \u03b1\u03bb\u03ac\u03c4\u03c9\u03bd \u03ad\u03c7\u03b5\u03b9 \u03c9\u03c2 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03b7\u03bd \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03bc\u03b5\u03c4\u03b1\u03c4\u03c1\u03bf\u03c0\u03ae \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2 \u03c3\u03b5 \u03c7\u03bf\u03bb\u03b9\u03ba\u03ac \u03ac\u03bb\u03b1\u03c4\u03b1 \u03c3\u03c4\u03bf \u03ae\u03c0\u03b1\u03c1, \u03ce\u03c3\u03c4\u03b5 \u03bd\u03b1 \u03b1\u03bd\u03b1\u03c0\u03bb\u03b7\u03c1\u03c9\u03b8\u03b5\u03af \u03b7 \u03b1\u03c0\u03ce\u03bb\u03b5\u03b9\u03ac \u03c4\u03bf\u03c5\u03c2. \u039c\u03b5 \u03b1\u03c5\u03c4\u03cc \u03c4\u03bf \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc \u03bc\u03b5\u03b9\u03ce\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03b7\u03c2 \u03b5\u03bd\u03b4\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03b9\u03b1\u03c2 \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2 \u03c3\u03c4\u03bf \u03ae\u03c0\u03b1\u03c1 \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bd\u03b5\u03c0\u03b1\u03ba\u03cc\u03bb\u03bf\u03c5\u03b8\u03b1 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03bd\u03c4\u03b9\u03c1\u03c1\u03bf\u03c0\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03bf \u03b1\u03c1\u03b9\u03b8\u03bc\u03cc\u03c2 \u03ba\u03b1\u03b9 \u03b7 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03c9\u03bd LDL \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03c9\u03bd \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03c6\u03ac\u03bd\u03b5\u03b9\u03b1 \u03c4\u03c9\u03bd \u03b7\u03c0\u03b1\u03c4\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c0\u03bf\u03c5 \u03b1\u03c5\u03be\u03ac\u03bd\u03bf\u03c5\u03bd \u03c0\u03b5\u03c1\u03b1\u03b9\u03c4\u03ad\u03c1\u03c9 \u03c4\u03bf \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03c3\u03bc\u03cc \u03c4\u03b7\u03c2 \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03c0\u03bb\u03ac\u03c3\u03bc\u03b1\u03c4\u03bf\u03c2 (28).<\/p>\n<h6 style=\"text-align: justify;\"><b>4.2.3. \u0395\u03b6\u03b5\u03c4\u03b9\u03bc\u03af\u03bc\u03c0\u03b7<\/b><\/h6>\n<p style=\"text-align: justify;\">\u0397 \u03b5\u03b6\u03b5\u03c4\u03b9\u03bc\u03af\u03bc\u03c0\u03b7 \u03b4\u03c1\u03b1 \u03bc\u03b5\u03b9\u03ce\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7\u03bd \u03b1\u03c0\u03bf\u03c1\u03c1\u03cc\u03c6\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03b5\u03bd\u03c4\u03b5\u03c1\u03b9\u03ba\u03ad\u03c2 \u03bb\u03ac\u03c7\u03bd\u03b5\u03c2 \u03b4\u03b9\u03b1\u03bc\u03ad\u03c3\u03bf\u03c5 \u03c4\u03b7\u03c2 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2 \u03c4\u03b7\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2 Niemann-Pick C1-like \u03c0\u03bf\u03c5 \u03b5\u03b4\u03c1\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03c8\u03b7\u03ba\u03c4\u03c1\u03bf\u03b5\u03b9\u03b4\u03ae \u03c0\u03b1\u03c1\u03c5\u03c6\u03ae \u03c4\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c4\u03bf\u03c5 \u03b5\u03bd\u03c4\u03ad\u03c1\u03bf\u03c5 \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03b7 \u03bc\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03bc\u03b5\u03c4\u03b1\u03c6\u03bf\u03c1\u03ac \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2 \u03c3\u03c4\u03bf \u03ae\u03c0\u03b1\u03c1. \u03a4\u03bf \u03c4\u03b5\u03bb\u03b9\u03ba\u03cc \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd LDL-R \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03c6\u03ac\u03bd\u03b5\u03b9\u03b1 \u03c4\u03c9\u03bd \u03b7\u03c0\u03b1\u03c4\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03ba\u03b1\u03b9 \u03b7 \u03c3\u03c5\u03bd\u03b1\u03ba\u03cc\u03bb\u03bf\u03c5\u03b8\u03b7 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03ba\u03ac\u03b8\u03b1\u03c1\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 LDL \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2. \u0397 \u03b5\u03b6\u03b5\u03c4\u03b9\u03bc\u03af\u03bc\u03c0\u03b7 \u03c3\u03c0\u03ac\u03bd\u03b9\u03b1 \u03c7\u03bf\u03c1\u03b7\u03b3\u03b5\u03af\u03c4\u03b1\u03b9 \u03c9\u03c2 \u03bc\u03bf\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1, \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7\u03bd \u03bf\u03c0\u03bf\u03af\u03b1 \u03b1\u03bd\u03b1\u03bc\u03ad\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 LDL \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2 \u03c0\u03bf\u03c5 \u03c6\u03c4\u03ac\u03bd\u03b5\u03b9 \u03c4\u03bf 18% \u03c4\u03c9\u03bd \u03b1\u03c1\u03c7\u03b9\u03ba\u03ce\u03bd \u03c4\u03b9\u03bc\u03ce\u03bd. \u039f \u03c3\u03c5\u03bd\u03ae\u03b8\u03b7\u03c2 \u03c4\u03c1\u03cc\u03c0\u03bf\u03c2 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03ae\u03c2 \u03c4\u03b7\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03b5 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc \u03bc\u03b5 \u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b5\u03c2, \u03bf\u03c0\u03cc\u03c4\u03b5 \u03ba\u03b1\u03b9 \u03b5\u03c0\u03b9\u03c4\u03c5\u03b3\u03c7\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c0\u03b5\u03c1\u03b1\u03b9\u03c4\u03ad\u03c1\u03c9 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b5\u03c0\u03b9\u03c0\u03ad\u03b4\u03c9\u03bd \u03c4\u03b7\u03c2 LDL \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2 \u03c0\u03bf\u03c5 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c6\u03c4\u03ac\u03c3\u03b5\u03b9 \u03ad\u03c9\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03bf 60% \u03b5\u03be\u03b1\u03b9\u03c4\u03af\u03b1\u03c2 \u03c4\u03bf\u03c5 \u03b4\u03b9\u03c0\u03bb\u03bf\u03cd \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03cd \u03b4\u03c1\u03ac\u03c3\u03b7\u03c2 (\u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b5\u03bd\u03c4\u03b5\u03c1\u03b9\u03ba\u03ae\u03c2 \u03b1\u03c0\u03bf\u03c1\u03c1\u03cc\u03c6\u03b7\u03c3\u03b7\u03c2 \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03b5\u03bd\u03b4\u03bf\u03b7\u03c0\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c3\u03cd\u03bd\u03b8\u03b5\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2 ) (28).<br \/>\n<b> 4.2.4. <\/b><b>LDL-\u03b1\u03c6\u03b1\u03af\u03c1\u03b5\u03c3\u03b7<\/b><\/p>\n<p style=\"text-align: justify;\">\u039c\u03b5 \u03c4\u03b7 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf \u03b1\u03c5\u03c4\u03ae \u03b1\u03c0\u03bf\u03bc\u03b1\u03ba\u03c1\u03cd\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c4\u03b1 \u03c3\u03c9\u03bc\u03b1\u03c4\u03af\u03b4\u03b9\u03b1 \u03c4\u03b7\u03c2 LDL \u03b1\u03c0\u03cc \u03c4\u03bf \u03c0\u03bb\u03ac\u03c3\u03bc\u03b1 \u03b4\u03b9\u03ac \u03bc\u03ad\u03c3\u03bf\u03c5 \u03c4\u03b7\u03c2 \u03c0\u03c1\u03cc\u03c3\u03b4\u03b5\u03c3\u03ae\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03bc\u03b5 \u03b7\u03c0\u03b1\u03c1\u03af\u03bd\u03b7 \u03ae \u03b8\u03b5\u03b9\u03ca\u03ba\u03ae \u03b4\u03b5\u03be\u03c4\u03c1\u03ac\u03bd\u03b7. \u0395\u03c6\u03b1\u03c1\u03bc\u03cc\u03b6\u03b5\u03c4\u03b1\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c3\u03b5 \u03bf\u03bc\u03cc\u03b6\u03c5\u03b3\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2, \u03c6\u03bf\u03c1\u03b5\u03af\u03c2 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03c9\u03bd \u03c4\u03bf\u03c5 LDL-R, \u03bc\u03b5 \u03c0\u03bf\u03bb\u03cd \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 LDL \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2 \u03bf\u03b9 \u03bf\u03c0\u03bf\u03af\u03bf\u03b9 \u03b4\u03b5\u03bd \u03ba\u03b1\u03b8\u03af\u03c3\u03c4\u03b1\u03c4\u03b1\u03b9 \u03b4\u03c5\u03bd\u03b1\u03c4\u03cc \u03bd\u03b1 \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03c4\u03bf\u03cd\u03bd \u03b5\u03c0\u03b1\u03c1\u03ba\u03ce\u03c2 \u03bc\u03b5 \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03b1\u03b3\u03c9\u03b3\u03ae \u03ae \u03b4\u03b5\u03bd \u03b1\u03bd\u03c4\u03b1\u03c0\u03bf\u03ba\u03c1\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b5\u03be\u03b1\u03b9\u03c4\u03af\u03b1\u03c2 \u03c4\u03bf\u03c5 \u03b5\u03af\u03b4\u03bf\u03c5\u03c2 \u03c4\u03b7\u03c2 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7\u03c2 (28).<\/p>\n<h6 style=\"text-align: justify;\"><b>4.2.5. \u039d\u03b5\u03cc\u03c4\u03b5\u03c1\u03bf\u03b9 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2 <\/b><\/h6>\n<p style=\"text-align: justify;\">\u03a3\u03c4\u03bf \u03b5\u03b3\u03b3\u03cd\u03c2 \u03bc\u03ad\u03bb\u03bb\u03bf\u03bd, \u03b1\u03bd\u03b1\u03bc\u03ad\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03b5\u03ba\u03c4\u03b9\u03bc\u03b7\u03b8\u03b5\u03af \u03b7 \u03b8\u03ad\u03c3\u03b7 \u03bd\u03b5\u03cc\u03c4\u03b5\u03c1\u03c9\u03bd \u03c5\u03c0\u03bf\u03bb\u03b9\u03c0\u03b9\u03b4\u03b1\u03b9\u03bc\u03b9\u03ba\u03ce\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03cc\u03bd\u03c4\u03c9\u03bd, \u03cc\u03c0\u03c9\u03c2 \u03bf\u03b9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03c4\u03b7\u03c2 \u03bc\u03b9\u03ba\u03c1\u03bf\u03c3\u03c9\u03bc\u03b9\u03b1\u03ba\u03ae\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2 \u03bc\u03b5\u03c4\u03b1\u03c6\u03bf\u03c1\u03ac\u03c2 \u03c4\u03c9\u03bd \u03c4\u03c1\u03b9\u03b3\u03bb\u03c5\u03ba\u03b5\u03c1\u03b9\u03b4\u03af\u03c9\u03bd (microsomal triglyceride transfer protein, MTP inhibitors), \u03bf\u03b9 \u03b5\u03ba\u03bb\u03b5\u03ba\u03c4\u03b9\u03ba\u03bf\u03af \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03c4\u03b7\u03c2 \u03c3\u03cd\u03bd\u03b8\u03b5\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 apoB100 (apo B100 antisense) \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ac \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03c3\u03b1\u03c4\u03b1 \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03b3\u03b9\u03b1 \u03c4\u03b7 PCSK9.\u00a0 \u039f\u03b9 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2 \u03b1\u03c5\u03c4\u03bf\u03af \u03c7\u03bf\u03c1\u03b7\u03b3\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b5\u03c0\u03b9\u03c0\u03c1\u03cc\u03c3\u03b8\u03b5\u03c4\u03b1 \u03c3\u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 \u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b7 (\u03c3\u03c4\u03b7 \u03bc\u03ad\u03b3\u03b9\u03c3\u03c4\u03b7 \u03b1\u03bd\u03b5\u03ba\u03c4\u03ae \u03b4\u03cc\u03c3\u03b7) \u03ba\u03b1\u03b9 \u03b5\u03b6\u03b5\u03c4\u03b9\u03bc\u03af\u03bc\u03c0\u03b7 \u03ba\u03b1\u03b9 \u03bf\u03b4\u03b7\u03b3\u03bf\u03cd\u03bd \u03c3\u03b5 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03b9\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c4\u03c9\u03bd \u03b5\u03c0\u03b9\u03c0\u03ad\u03b4\u03c9\u03bd \u03c4\u03b7\u03c2 LDL \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2 (29). O\u03b9 \u03bd\u03b5\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b4\u03c5\u03bd\u03b1\u03c4\u03cc\u03c4\u03b7\u03c4\u03b5\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03ce\u03c0\u03b9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c5\u03c0\u03b5\u03c1\u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03bf\u03bb\u03b1\u03b9\u03bc\u03af\u03b1\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ce\u03bd \u03b5\u03ba\u03b2\u03ac\u03c3\u03b5\u03c9\u03bd \u03ba\u03b1\u03b9 \u03b7 \u03c0\u03b9\u03b8\u03b1\u03bd\u03ae \u03b1\u03b4\u03b5\u03b9\u03bf\u03b4\u03cc\u03c4\u03b7\u03c3\u03ae \u03c4\u03bf\u03c5\u03c2 \u03c9\u03c2 \u03b5\u03bd\u03b4\u03b5\u03b9\u03ba\u03bd\u03c5\u03cc\u03bc\u03b5\u03bd\u03b5\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b1\u03c1\u03b5\u03bc\u03b2\u03ac\u03c3\u03b5\u03b9\u03c2 \u03b1\u03bd\u03b1\u03bc\u03ad\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03c3\u03c5\u03bc\u03b2\u03ac\u03bb\u03b5\u03b9 \u03c3\u03c4\u03b7 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03bc\u03b5 \u03b5\u03c4\u03b5\u03c1\u03cc\u03b6\u03c5\u03b3\u03b7 \u03ae \u03bf\u03bc\u03cc\u03b6\u03c5\u03b3\u03b7 FH.<\/p>\n<h4 style=\"text-align: justify;\"><b>5. \u03a3\u03cd\u03bd\u03bf\u03c8\u03b7<\/b><\/h4>\n<ul style=\"text-align: justify;\">\n<li>\u0397 FH \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03c3\u03c4\u03b1 \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 \u03c4\u03bf\u03c5 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03c4\u03b7\u03c2 LDL\u00a0 (LDL-R0, \u03c4\u03b7\u03c2 \u03b1\u03c0\u03bf\u03bb\u03b9\u03c0\u03bf\u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2 B-100, \u03c4\u03b7\u03c2 PCSK9 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2 LDL-R adaptor protein 1.<\/li>\n<li>\u0392\u03b1\u03c1\u03cd\u03c4\u03b5\u03c1\u03b7 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03bf\u03c5 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03bf\u03c5\u03bd \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03c4\u03bf\u03c5 LDL-R \u03ba\u03b1\u03b9 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b1 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03c0\u03bf\u03c5 \u03b1\u03c6\u03bf\u03c1\u03bf\u03cd\u03bd \u03c4\u03b7 \u03c3\u03cd\u03bd\u03b8\u03b5\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2.<\/li>\n<li>\u039f \u03b3\u03bf\u03bd\u03b9\u03b4\u03b9\u03b1\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03c4\u03bf \u03c7\u03c1\u03c5\u03c3\u03cc \u03ba\u03b1\u03bd\u03cc\u03bd\u03b1 (gold standard) \u03c4\u03b7\u03c2 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7\u03c2. \u039f\u03b9 1<sup>\u03bf\u03c5<\/sup> \u03b2\u03b1\u03b8\u03bc\u03bf\u03cd \u03c3\u03c5\u03b3\u03b3\u03b5\u03bd\u03b5\u03af\u03c2 \u03b1\u03c4\u03cc\u03bc\u03c9\u03bd \u03bc\u03b5 \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03bc\u03ad\u03bd\u03b7 FH \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b3\u03bf\u03bd\u03b9\u03b4\u03b9\u03b1\u03ba\u03ac.<\/li>\n<li>\u0397 \u03ad\u03b3\u03ba\u03b1\u03b9\u03c1\u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5 \u03c3\u03c5\u03bc\u03b2\u03ac\u03bb\u03bb\u03b5\u03b9 \u03c3\u03c4\u03b7 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7\u03c2 \u03c0\u03c1\u03ce\u03b9\u03bc\u03b7\u03c2 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ae\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5.<\/li>\n<li>\u0399\u03b4\u03b1\u03bd\u03b9\u03ba\u03ac, \u03bf\u03b9 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 FH \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b5\u03c0\u03b9\u03c4\u03c5\u03b3\u03c7\u03ac\u03bd\u03bf\u03c5\u03bd \u03bd\u03b1 \u03bc\u03b5\u03b9\u03ce\u03c3\u03bf\u03c5\u03bd \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03b7\u03c2 LDL \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf \u03b1\u03c0\u03cc 50% \u03c3\u03b5 \u03c3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c0\u03c1\u03b9\u03bd \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03ad\u03bd\u03b1\u03c1\u03be\u03b7 \u03c4\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2.<\/li>\n<li>\u039f\u03b9 \u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b5\u03c2 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03bf\u03cd\u03bd \u03c4\u03bf\u03bd \u03b1\u03ba\u03c1\u03bf\u03b3\u03c9\u03bd\u03b9\u03b1\u03af\u03bf \u03bb\u03af\u03b8\u03bf \u03c4\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03c4\u03b7\u03c2 FH. \u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03b5\u03be\u03b1\u03b9\u03c4\u03af\u03b1\u03c2 \u03c4\u03c9\u03bd \u03c0\u03bf\u03bb\u03cd \u03c5\u03c8\u03b7\u03bb\u03ce\u03bd \u03b5\u03c0\u03b9\u03c0\u03ad\u03b4\u03c9\u03bd \u03c4\u03b7\u03c2 LDL \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2, \u03c3\u03c5\u03c7\u03bd\u03ac \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03bf \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc\u03c2 \u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b7\u03c2 \u03bc\u03b5 \u03ac\u03bb\u03bb\u03bf\u03c5\u03c2 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2 \u03cc\u03c0\u03c9\u03c2 \u03b7 \u03b5\u03b6\u03b5\u03c4\u03b9\u03bc\u03af\u03bc\u03c0\u03b7 \u03ba\u03b1\u03b9 \u03bf\u03b9 \u03c1\u03b7\u03c4\u03af\u03bd\u03b5\u03c2 \u03b4\u03ad\u03c3\u03bc\u03b5\u03c5\u03c3\u03b7\u03c2 \u03c7\u03bf\u03bb\u03b9\u03ba\u03ce\u03bd \u03bf\u03be\u03ad\u03c9\u03bd.<\/li>\n<li>\u0397 \u03c4\u03b5\u03c7\u03bd\u03b9\u03ba\u03ae \u03c4\u03b7\u03c2 LDL-\u03b1\u03c6\u03b1\u03af\u03c1\u03b5\u03c3\u03b7\u03c2 \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03b5\u03b9 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03b4\u03b5\u03cd\u03c4\u03b5\u03c1\u03b7\u03c2 \u03b3\u03c1\u03b1\u03bc\u03bc\u03ae\u03c2 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03c0\u03bf\u03bb\u03cd \u03c5\u03c8\u03b7\u03bb\u03ac \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2 (\u03c3\u03c5\u03bd\u03b7\u03b8\u03ad\u03c3\u03c4\u03b5\u03c1\u03b1 \u03bf\u03bc\u03bf\u03b6\u03c5\u03b3\u03ce\u03c4\u03b5\u03c2) \u03bf\u03b9 \u03bf\u03c0\u03bf\u03af\u03bf\u03b9 \u03b4\u03b5\u03bd \u03b1\u03bd\u03c4\u03b1\u03c0\u03bf\u03ba\u03c1\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b5\u03c0\u03b1\u03c1\u03ba\u03ce\u03c2 \u03c3\u03c4\u03b7 \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03b1\u03b3\u03c9\u03b3\u03ae.<\/li>\n<li>\u0397 \u03b5\u03b9\u03c3\u03b1\u03b3\u03c9\u03b3\u03ae \u03bd\u03b5\u03cc\u03c4\u03b5\u03c1\u03c9\u03bd \u03c5\u03c0\u03bf\u03bb\u03b9\u03c0\u03b9\u03b4\u03b1\u03b9\u03bc\u03b9\u03ba\u03ce\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03cc\u03bd\u03c4\u03c9\u03bd \u03b1\u03bd\u03b1\u03bc\u03ad\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03c3\u03c5\u03bc\u03b2\u03ac\u03bb\u03b5\u03b9 \u03c3\u03c4\u03b7 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 FH.<\/li>\n<\/ul>\n<h4 style=\"text-align: justify;\"><b>\u0392\u03b9\u03b2\u03bb\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1<\/b><\/h4>\n<ol>\n<li style=\"text-align: justify;\">Khachadurian AK. Clinical features, diagnosis and frequency of familial hypercholesterolemia. Beitr Infusionsther. 1988;23:26-32.<\/li>\n<li style=\"text-align: justify;\">Leigh SE, Foster AH, Whittall RA, Hubbart CS, Humphries SE. Update and analysis of the University College London low density lipoprotein receptor familial hypercholesterolemia database. Ann Hum Genet. 2008;72(Pt 4):485-98.<\/li>\n<li style=\"text-align: justify;\">Tolleshaug H, Goldstein JL, Schneider WJ, Brown MS. Posttranslational processing of the LDL receptor and its genetic disruption in familial hypercholesterolemia. Cell. 1982;30(3):715-24.<\/li>\n<li style=\"text-align: justify;\">Hobbs HH, Leitersdorf E, Goldstein JL, Brown MS, Russell DW. Multiple crm- mutations in familial hypercholesterolemia. Evidence for 13 alleles, including four deletions. J Clin Invest. 1988;81(3):909-17.<\/li>\n<li style=\"text-align: justify;\">Yamamoto T, Davis CG, Brown MS, Schneider WJ, Casey ML, Goldstein JL, et al. The human LDL receptor: a cysteine-rich protein with multiple Alu sequences in its mRNA. Cell. 1984;39(1):27-38.<\/li>\n<li style=\"text-align: justify;\">Lehrman MA, Schneider WJ, Sudhof TC, Brown MS, Goldstein JL, Russell DW. Mutation in LDL receptor: Alu-Alu recombination deletes exons encoding transmembrane and cytoplasmic domains. Science. 1985;227(4683):140-6.<\/li>\n<li style=\"text-align: justify;\">Davis CG, Elhammer A, Russell DW, Schneider WJ, Kornfeld S, Brown MS, et al. Deletion of clustered O-linked carbohydrates does not impair function of low density lipoprotein receptor in transfected fibroblasts. J Biol Chem. 1986;261(6):2828-38.<\/li>\n<li style=\"text-align: justify;\">Hobbs HH, Brown MS, Goldstein JL. Molecular genetics of the LDL receptor gene in familial hypercholesterolemia. Hum Mutat. 1992;1(6):445-66.<\/li>\n<li style=\"text-align: justify;\">Myant NB. Familial defective apolipoprotein B-100: a review, including some comparisons with familial hypercholesterolaemia. Atherosclerosis. 1993;104(1-2):1-18.<\/li>\n<li style=\"text-align: justify;\">Innerarity TL, Weisgraber KH, Arnold KS, Mahley RW, Krauss RM, Vega GL, et al. Familial defective apolipoprotein B-100: low density lipoproteins with abnormal receptor binding. Proc Natl Acad Sci U S A. 1987;84(19):6919-23.<\/li>\n<li style=\"text-align: justify;\">Fouchier SW, Kastelein JJ, Defesche JC. Update of the molecular basis of familial hypercholesterolemia in The Netherlands. Hum Mutat. 2005;26(6):550-6.<\/li>\n<li style=\"text-align: justify;\">Qian YW, Schmidt RJ, Zhang Y, Chu S, Lin A, Wang H, et al. Secreted PCSK9 downregulates low density lipoprotein receptor through receptor-mediated endocytosis. J Lipid Res. 2007;48(7):1488-98.<\/li>\n<li style=\"text-align: justify;\">Cameron J, Holla OL, Ranheim T, Kulseth MA, Berge KE, Leren TP. Effect of mutations in the PCSK9 gene on the cell surface LDL receptors. Hum Mol Genet. 2006;15(9):1551-8.<\/li>\n<li style=\"text-align: justify;\">Cunningham D, Danley DE, Geoghegan KF, Griffor MC, Hawkins JL, Subashi TA, et al. Structural and biophysical studies of PCSK9 and its mutants linked to familial hypercholesterolemia. Nat Struct Mol Biol. 2007;14(5):413-9.<\/li>\n<li style=\"text-align: justify;\">Pandit S, Wisniewski D, Santoro JC, Ha S, Ramakrishnan V, Cubbon RM, et al. Functional analysis of sites within PCSK9 responsible for hypercholesterolemia. J Lipid Res. 2008;49(6):1333-43.<\/li>\n<li style=\"text-align: justify;\">Abifadel M, Rabes JP, Jambart S, Halaby G, Gannage-Yared MH, Sarkis A, et al. The molecular basis of familial hypercholesterolemia in Lebanon: spectrum of LDLR mutations and role of PCSK9 as a modifier gene. Hum Mutat. 2009;30(7):E682-91.<\/li>\n<li style=\"text-align: justify;\">Soutar AK, Naoumova RP, Traub LM. Genetics, clinical phenotype, and molecular cell biology of autosomal recessive hypercholesterolemia. Arterioscler Thromb Vasc Biol. 2003;23(11):1963-70.<\/li>\n<li style=\"text-align: justify;\">Garcia CK, Wilund K, Arca M, Zuliani G, Fellin R, Maioli M, et al. Autosomal recessive hypercholesterolemia caused by mutations in a putative LDL receptor adaptor protein. Science. 2001;292(5520):1394-8.<\/li>\n<li style=\"text-align: justify;\">Pisciotta L, Priore Oliva C, Pes GM, Di Scala L, Bellocchio A, Fresa R, et al. Autosomal recessive hypercholesterolemia (ARH) and homozygous familial hypercholesterolemia (FH): a phenotypic comparison. Atherosclerosis. 2006;188(2):398-405.<\/li>\n<li style=\"text-align: justify;\">Naoumova RP, Neuwirth C, Lee P, Miller JP, Taylor KG, Soutar AK. Autosomal recessive hypercholesterolaemia: long-term follow up and response to treatment. Atherosclerosis. 2004;174(1):165-72.<\/li>\n<li style=\"text-align: justify;\">Tietge UJ, Genschel J, Schmidt HH. A Q136Stop mutation in the ARH gene causing autosomal recessive hypercholesterolaemia with severely delayed LDL catabolism. J Intern Med. 2003;253(5):582-3.<\/li>\n<li style=\"text-align: justify;\">Hovingh GK, Davidson MH, Kastelein JJ, O&#8217;Connor AM. Diagnosis and treatment of familial hypercholesterolaemia. Eur Heart J.<\/li>\n<li style=\"text-align: justify;\">Goldberg AC, Hopkins PN, Toth PP, Ballantyne CM, Rader DJ, Robinson JG, et al. Familial hypercholesterolemia: screening, diagnosis and management of pediatric and adult patients: clinical guidance from the National Lipid Association Expert Panel on Familial Hypercholesterolemia. Journal of clinical lipidology. 2011;5(3):133-40.<\/li>\n<li style=\"text-align: justify;\">Last IamofhNcgCNIfHaCEAahwnouc.<\/li>\n<li style=\"text-align: justify;\">Reiner Z, Catapano AL, De Backer G, Graham I, Taskinen MR, Wiklund O, et al. ESC\/EAS Guidelines for the management of dyslipidaemias: the Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS). European heart journal. 2011;32(14):1769-818.<\/li>\n<li style=\"text-align: justify;\">Grundy SM, Cleeman JI, Merz CN, Brewer HB, Jr., Clark LT, Hunninghake DB, et al. Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines. Journal of the American College of Cardiology. 2004;44(3):720-32.<\/li>\n<li style=\"text-align: justify;\">Genest J, McPherson R, Frohlich J, Anderson T, Campbell N, Carpentier A, et al. 2009 Canadian Cardiovascular Society\/Canadian guidelines for the diagnosis and treatment of dyslipidemia and prevention of cardiovascular disease in the adult &#8211; 2009 recommendations. The Canadian journal of cardiology. 2009;25(10):567-79.<\/li>\n<li style=\"text-align: justify;\">Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection E, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation 2002;106:3143-3421.<\/li>\n<li style=\"text-align: justify;\">Alonso R, Mata P, Zambon D, Mata N, Fuentes-Jimenez F. Early diagnosis and treatment of familial hypercholesterolemia: improving patient outcomes. Expert review of cardiovascular therapy. 2013;11(3):327-42. Epub 2013\/03\/09.<\/li>\n<\/ol>\n<hr style=\"width: 100%; border-width: 1px; border-style: solid; border-color: #CCCCCC; color: #ffffff;\" noshade=\"noshade\" width=\"100%\" \/>\n<p>Created: February 25, 2015<br \/>\nLast update: February 25, 2015<\/p>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; \u0391\u03bd\u03b1\u03c3\u03c4\u03b1\u03c3\u03af\u03b1 \u039a\u03b5\u03ae \u0399\u03b1\u03c4\u03c1\u03cc\u03c2 \u0395\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03bf\u03bd\u03b9\u03ba\u03cc\u03c2 \u03a3\u03c5\u03bd\u03b5\u03c1\u03b3\u03ac\u03c4\u03b7\u03c2 \u03c4\u03bf\u03c5 \u0399\u03b1\u03c4\u03c1\u03b5\u03af\u03bf\u03c5 \u039c\u03b5\u03bb\u03ad\u03c4\u03b7\u03c2 \u03c4\u03c9\u03bd \u0394\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ce\u03bd \u03c4\u03bf\u03c5 \u039c\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03c3\u03bc\u03bf\u03cd \u03c4\u03c9\u03bd \u039b\u03b9\u03c0\u03b9\u03b4\u03af\u03c9\u03bd \u03c4\u03bf\u03c5 \u03a0\u03b1\u03bd\u03b5\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03b9\u03b1\u03ba\u03bf\u03cd \u039d\u03bf\u03c3\u03bf\u03ba\u03bf\u03bc\u03b5\u03af\u03bf\u03c5 \u0399\u03c9\u03b1\u03bd\u03bd\u03af\u03bd\u03c9\u03bd \u03a7\u03b1\u03c1\u03ac\u03bb\u03b1\u03bc\u03c0\u03bf\u03c2 \u039c\u03b7\u03bb\u03b9\u03ce\u03bd\u03b7\u03c2 \u0391\u03bd\u03b1\u03c0\u03bb\u03b7\u03c1\u03c9\u03c4\u03ae\u03c2 \u039a\u03b1\u03b8\u03b7\u03b3\u03b7\u03c4\u03ae\u03c2 \u03a0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03af\u03b1\u03c2 \u0399\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03a3\u03c7\u03bf\u03bb\u03ae \u03a0\u03b1\u03bd\u03b5\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03af\u03bf\u03c5 \u0399\u03c9\u03b1\u03bd\u03bd\u03af\u03bd\u03c9\u03bd 1. \u0395\u03b9\u03c3\u03b1\u03b3\u03c9\u03b3\u03ae \u0397 \u03bf\u03b9\u03ba\u03bf\u03b3\u03b5\u03bd\u03ae\u03c2 \u03c5\u03c0\u03b5\u03c1\u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03bf\u03bb\u03b1\u03b9\u03bc\u03af\u03b1 (Familial Hypercholesterolemia, FH) \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b5\u03c1\u03b7 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ae \u03c4\u03bf\u03c5 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03c3\u03bc\u03bf\u03cd. \u03a7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c5\u03c8\u03b7\u03bb\u03ac \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2 \u03c4\u03c9\u03bd \u03c7\u03b1\u03bc\u03b7\u03bb\u03ae\u03c2 \u03c0\u03c5\u03ba\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03bb\u03b9\u03c0\u03bf\u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03ce\u03bd (low density lipoprotein [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"pageCustom.php","meta":{"footnotes":""},"tags":[],"_links":{"self":[{"href":"https:\/\/e-endocrinology.gr\/index.php?rest_route=\/wp\/v2\/pages\/1108"}],"collection":[{"href":"https:\/\/e-endocrinology.gr\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/e-endocrinology.gr\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/e-endocrinology.gr\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/e-endocrinology.gr\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1108"}],"version-history":[{"count":13,"href":"https:\/\/e-endocrinology.gr\/index.php?rest_route=\/wp\/v2\/pages\/1108\/revisions"}],"predecessor-version":[{"id":1199,"href":"https:\/\/e-endocrinology.gr\/index.php?rest_route=\/wp\/v2\/pages\/1108\/revisions\/1199"}],"wp:attachment":[{"href":"https:\/\/e-endocrinology.gr\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1108"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/e-endocrinology.gr\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1108"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}