{"id":1090,"date":"2015-02-23T00:27:22","date_gmt":"2015-02-22T21:27:22","guid":{"rendered":"http:\/\/e-endocrinology.gr\/?page_id=1090"},"modified":"2015-03-18T02:55:32","modified_gmt":"2015-03-17T23:55:32","slug":"18-11-o-%ce%ba%ce%b1%cf%86%ce%ad%cf%82-%ce%ba%ce%b1%ce%b9-%cf%84%ce%bf-%ce%b5%ce%bd%ce%b4%ce%bf%ce%ba%cf%81%ce%b9%ce%bd%ce%b9%ce%ba%cf%8c-%cf%83%cf%8d%cf%83%cf%84%ce%b7%ce%bc%ce%b1","status":"publish","type":"page","link":"https:\/\/e-endocrinology.gr\/?page_id=1090","title":{"rendered":"18.11 O \u03ba\u03b1\u03c6\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03bf \u03b5\u03bd\u03b4\u03bf\u03ba\u03c1\u03b9\u03bd\u03b9\u03ba\u03cc \u03c3\u03cd\u03c3\u03c4\u03b7\u03bc\u03b1"},"content":{"rendered":"

\n \n \"Print\n <\/a>\n <\/div><\/p>\n

 <\/p>\n

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\n\u0395\u03bd\u03b4\u03bf\u03ba\u03c1\u03b9\u03bd\u03bf\u03bb\u03cc\u03b3\u03bf\u03c2
\n\u03a4\u03bf\u03bc\u03ad\u03b1\u03c2 \u039c\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03c3\u03bc\u03bf\u03cd \u0399\u03b1\u03c4\u03c1\u03b9\u03ba\u03bf\u03cd \u039a\u03ad\u03bd\u03c4\u03c1\u03bf\u03c5 \u0391\u03b8\u03b7\u03bd\u03ce\u03bd<\/p>\n

1. \u0395\u03b9\u03c3\u03b1\u03b3\u03c9\u03b3\u03ae<\/b><\/h4>\n

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\u0397 \u03c0\u03b5\u03c1\u03b9\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c6\u03ad \u03c3\u03b5 \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7 \u03b5\u03be\u03b1\u03c1\u03c4\u03ac\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03c0\u03bf\u03b9\u03ba\u03b9\u03bb\u03af\u03b1 \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c1\u03c0\u03bf\u03cd, \u03b1\u03c0\u03cc \u03c4\u03bf \u03b2\u03b1\u03b8\u03bc\u03cc \u03ba\u03b1\u03b2\u03bf\u03c5\u03c1\u03b4\u03af\u03c3\u03bc\u03b1\u03c4\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf \u03b5\u03ba\u03c7\u03cd\u03bb\u03b9\u03c3\u03b7\u03c2. \u0393\u03b5\u03bd\u03b9\u03ba\u03ac, \u03cc\u03c3\u03bf \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf \u03c8\u03b7\u03bc\u03ad\u03bd\u03bf\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf \u03ba\u03cc\u03ba\u03ba\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c6\u03ad \u03c4\u03cc\u03c3\u03bf \u03bc\u03b9\u03ba\u03c1\u03cc\u03c4\u03b5\u03c1\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03c0\u03bf\u03c3\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03b5\u03bc\u03c0\u03b5\u03c1\u03b9\u03b5\u03c7\u03cc\u03bc\u03b5\u03bd\u03b7\u03c2 \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7\u03c2. \u0391\u03bd\u03b1\u03c6\u03bf\u03c1\u03b9\u03ba\u03ac \u03bc\u03b5 \u03c4\u03b7 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf \u03b5\u03ba\u03c7\u03cd\u03bb\u03b9\u03c3\u03b7\u03c2, 1 \u03c6\u03bb\u03b9\u03c4\u03b6\u03ac\u03bd\u03b9 220 ml \u03ba\u03b1\u03c6\u03ad \u0395\u03bb\u03bb\u03b7\u03bd\u03b9\u03ba\u03bf\u03cd \u03ad\u03c7\u03b5\u03b9 80-135 mg \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7\u03c2, 1 \u03c6\u03bb\u03b9\u03c4\u03b6\u03ac\u03bd\u03b9 220 ml \u03ba\u03b1\u03c6\u03ad \u03c6\u03af\u03bb\u03c4\u03c1\u03bf\u03c5 \u03ad\u03c7\u03b5\u03b9 115-175 mg \u03ba\u03b1\u03b9 1 \u03c6\u03bb\u03b9\u03c4\u03b6\u03ac\u03bd\u03b9 45-60 ml \u03b5\u03c3\u03c0\u03c1\u03ad\u03c3\u03bf 100 mg (1). \u039f \u03c3\u03c4\u03b9\u03b3\u03bc\u03b9\u03b1\u03af\u03bf\u03c2 \u03ba\u03b1\u03c6\u03ad\u03c2, \u03c0\u03b1\u03c1\u03ac \u03c4\u03b7 \u03b3\u03b5\u03bd\u03b9\u03ba\u03ac \u03b1\u03bd\u03c4\u03af\u03b8\u03b5\u03c4\u03b7 \u03b1\u03bd\u03c4\u03af\u03bb\u03b7\u03c8\u03b7, \u03c0\u03b5\u03c1\u03b9\u03ad\u03c7\u03b5\u03b9 \u03bc\u03b9\u03ba\u03c1\u03cc\u03c4\u03b5\u03c1\u03b7 \u03c0\u03bf\u03c3\u03cc\u03c4\u03b7\u03c4\u03b1 \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03ac\u03bb\u03bb\u03b1 \u03b5\u03af\u03b4\u03b7 \u03ba\u03b1\u03c6\u03ad (\u03bc\u03ad\u03c3\u03b7 \u03c0\u03b5\u03c1\u03b9\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b1\u03bd\u03ac \u03c6\u03bb\u03b9\u03c4\u03b6\u03ac\u03bd\u03b9 66\u00a0mg \u03ba\u03b1\u03b9 \u03bc\u03b5 \u03cc\u03c1\u03b9\u03b1 \u03c3\u03c4\u03b9\u03c2 \u03b4\u03b9\u03ac\u03c6\u03bf\u03c1\u03b5\u03c2 \u03b1\u03bd\u03b1\u03bb\u03cd\u03c3\u03b5\u03b9\u03c2 29\u2013117\u00a0mg).<\/p>\n

\u0397 \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c6\u03ad \u03c3\u03c4\u03b7\u03bd \u03c5\u03b3\u03b5\u03af\u03b1 \u03c4\u03bf\u03c5 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03bf\u03c5 \u03ad\u03c7\u03b5\u03b9 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03b5\u03b9 \u03b1\u03bd\u03c4\u03b9\u03ba\u03b5\u03af\u03bc\u03b5\u03bd\u03bf \u03c0\u03bf\u03bb\u03bb\u03ce\u03bd \u03bc\u03b5\u03bb\u03b5\u03c4\u03ce\u03bd. \u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03c4\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03c0\u03bf\u03b9\u03ba\u03af\u03bb\u03bf\u03c5\u03bd \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03ac\u03c0\u03bf\u03c8\u03b7 \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c4\u03ac \u03c0\u03cc\u03c3\u03bf\u03bd \u03b7 \u03ba\u03b1\u03c4\u03b1\u03bd\u03ac\u03bb\u03c9\u03c3\u03b7 \u03ba\u03b1\u03c6\u03ad \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03c0\u03b9\u03b2\u03b1\u03c1\u03c5\u03bd\u03c4\u03b9\u03ba\u03ae \u03ae \u03ae\u03c0\u03b9\u03b1 \u03b5\u03c5\u03b5\u03c1\u03b3\u03b5\u03c4\u03b9\u03ba\u03ae \u03c3\u03b5 \u03c5\u03b3\u03b9\u03b5\u03af\u03c2 \u03b5\u03bd\u03ae\u03bb\u03b9\u03ba\u03b5\u03c2. \u0394\u03b5\u03bd \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03be\u03b5\u03c7\u03bd\u03ac\u03bc\u03b5 \u03cc\u03c4\u03b9 \u03bf \u03ba\u03b1\u03c6\u03ad\u03c2, \u03b5<\/b>\u03ba\u03c4\u03cc\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7, \u03c0\u03b5\u03c1\u03b9\u03ad\u03c7\u03b5\u03b9 \u03ba\u03b1\u03b9 \u03ac\u03bb\u03bb\u03b1 \u03c3\u03c5\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03ac, \u03cc\u03c0\u03c9\u03c2 \u03c6\u03b1\u03b9\u03bd\u03cc\u03bb\u03b5\u03c2, \u03bd\u03b9\u03b1\u03c3\u03af\u03bd\u03b7, \u03bc\u03b1\u03b3\u03bd\u03ae\u03c3\u03b9\u03bf \u03ba\u03b1\u03b9 \u03ba\u03ac\u03bb\u03b9\u03bf, \u03c4\u03b1 \u03bf\u03c0\u03bf\u03af\u03b1 \u03b5\u03bd\u03b4\u03ad\u03c7\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd\u00a0 \u03b8\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03ae \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c3\u03c4\u03b7\u03bd \u03c5\u03b3\u03b5\u03af\u03b1. \u0388\u03c4\u03c3\u03b9, \u03bb\u03cc\u03b3\u03c9 \u03c4\u03b7\u03c2 \u03c0\u03b5\u03c1\u03b9\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03ac\u03c2 \u03c4\u03bf\u03c5 \u03c3\u03c4\u03b1 \u03b4\u03b9\u03c4\u03b5\u03c1\u03c0\u03ad\u03bd\u03b9\u03b1 \u03ba\u03b1\u03c6\u03b5\u03c3\u03c4\u03cc\u03bb\u03b7 \u03ba\u03b1\u03b9 \u03ba\u03b1\u03c7\u03b5\u03cc\u03bb\u03b7 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03b7\u03c2 \u03bf\u03bb\u03b9\u03ba\u03ae\u03c2 \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2 \u03c3\u03c4\u03bf \u03b1\u03af\u03bc\u03b1, \u03b5\u03bd\u03ce \u03bb\u03cc\u03b3\u03c9 \u03c4\u03bf\u03c5 \u03c7\u03bb\u03c9\u03c1\u03bf\u03b3\u03b5\u03bd\u03b9\u03ba\u03bf\u03cd \u03bf\u03be\u03ad\u03bf\u03c2, \u03c4\u03c9\u03bd \u03c6\u03bb\u03b1\u03b2\u03bf\u03bd\u03bf\u03b5\u03b9\u03b4\u03ce\u03bd, \u03c4\u03c9\u03bd \u03bc\u03b5\u03bb\u03b1\u03bd\u03bf\u03b5\u03b9\u03b4\u03b9\u03bd\u03ce\u03bd, \u03c4\u03c9\u03bd \u03c6\u03bf\u03c5\u03c1\u03b1\u03bd\u03af\u03c9\u03bd, \u03c4\u03c9\u03bd \u03c0\u03c5\u03c1\u03c1\u03bf\u03bb\u03ce\u03bd \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03bc\u03b1\u03bb\u03c4\u03cc\u03bb\u03b7\u03c2 \u03b1\u03c3\u03ba\u03b5\u03af \u03b1\u03bd\u03c4\u03b9\u03bf\u03be\u03b5\u03b9\u03b4\u03c9\u03c4\u03b9\u03ba\u03ae \u03b4\u03c1\u03ac\u03c3\u03b7 (2).<\/p>\n

\u0391\u03bd\u03b1\u03c6\u03bf\u03c1\u03b9\u03ba\u03ac \u03bc\u03b5 \u03c4\u03b7\u03bd \u03ba\u03b1\u03c4\u03b1\u03bd\u03ac\u03bb\u03c9\u03c3\u03b7 \u03ba\u03b1\u03c6\u03ad \u03c3\u03c4\u03bf\u03bd \u0395\u03bb\u03bb\u03b7\u03bd\u03b9\u03ba\u03cc \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03cc \u03ad\u03c7\u03bf\u03c5\u03bc\u03b5 \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03b4\u03b7\u03bc\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 ATTICA (3).H \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03ad\u03b4\u03b5\u03b9\u03be\u03b5 \u03cc\u03c4\u03b9 \u03c4\u03bf 9% \u03c4\u03c9\u03bd \u03b1\u03bd\u03b4\u03c1\u03ce\u03bd \u03b4\u03b5\u03bd \u03ba\u03b1\u03c4\u03b1\u03bd\u03ac\u03bb\u03c9\u03bd\u03b5 \u03ba\u03b1\u03c6\u03ad, \u03c4\u03bf 53% \u03ba\u03b1\u03c4\u03b1\u03bd\u03ac\u03bb\u03c9\u03bd\u03b5 <200 ml\/\u03b7\u03bc\u03ad\u03c1\u03b1, \u03c4\u03bf 36% 200-400 ml\/\u03b7\u03bc\u03ad\u03c1\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03bf 2% >400 ml\/\u03b7\u03bc\u03ad\u03c1\u03b1. \u0391\u03bd\u03b1\u03c6\u03bf\u03c1\u03b9\u03ba\u03ac \u03bc\u03b5 \u03c4\u03b9\u03c2 \u03b3\u03c5\u03bd\u03b1\u03af\u03ba\u03b5\u03c2, \u03c4\u03bf 24% \u03b4\u03b5\u03bd \u03ba\u03b1\u03c4\u03b1\u03bd\u03ac\u03bb\u03c9\u03bd\u03b5 \u03ba\u03b1\u03c6\u03ad, \u03c4\u03bf 61% \u03ba\u03b1\u03c4\u03b1\u03bd\u03ac\u03bb\u03c9\u03bd\u03b5 <200 ml\/\u03b7\u03bc\u03ad\u03c1\u03b1, \u03c4\u03bf 14% 200-400 ml\/\u03b7\u03bc\u03ad\u03c1\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03bf 1% >400 ml\/\u03b7\u03bc\u03ad\u03c1\u03b1. \u0395\u03c0\u03bf\u03bc\u03ad\u03bd\u03c9\u03c2, \u03c4\u03bf \u03c3\u03cd\u03bd\u03bf\u03bb\u03bf \u03c0\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03ac \u03c4\u03bf\u03c5 \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03bf\u03cd \u03ba\u03b1\u03c4\u03b1\u03bd\u03b1\u03bb\u03ce\u03bd\u03b5\u03b9 <300 mg \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7\u03c2 \u03c4\u03b7\u03bd \u03b7\u03bc\u03ad\u03c1\u03b1. \u0393\u03b9\u03b1 \u03bb\u03cc\u03b3\u03bf\u03c5\u03c2 \u03ba\u03b1\u03b8\u03b1\u03c1\u03ac \u03c0\u03bb\u03b7\u03c1\u03bf\u03c6\u03bf\u03c1\u03b9\u03b1\u03ba\u03bf\u03cd\u03c2 \u03bd\u03b1 \u03b1\u03bd\u03b1\u03c6\u03ad\u03c1\u03bf\u03c5\u03bc\u03b5 \u03b5\u03b4\u03ce \u03cc\u03c4\u03b9 \u03b7 \u03bc\u03ad\u03c3\u03b7 \u03b8\u03b1\u03bd\u03b1\u03c4\u03b7\u03c6\u03cc\u03c1\u03b1 \u03b4\u03cc\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7 (1750 mg\/\u03ba\u03bb. \u03a3\u0392) \u03b5\u03af\u03bd\u03b1\u03b9 \u03c7\u03b9\u03bb\u03b9\u03ac\u03b4\u03b5\u03c2 \u03c6\u03bf\u03c1\u03ad\u03c2 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7, \u03b1\u03ba\u03cc\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03c0\u03bf\u03bb\u03cd \u03bc\u03b5\u03b3\u03ac\u03bb\u03b7 \u03b7\u03bc\u03b5\u03c1\u03ae\u03c3\u03b9\u03b1 \u03ba\u03b1\u03c4\u03b1\u03bd\u03ac\u03bb\u03c9\u03c3\u03b7 \u03ba\u03b1\u03c6\u03ad.<\/p>\n

\u0391\u03bd \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1 \u03b1\u03c5\u03c4\u03ac \u03b4\u03b5\u03af\u03c7\u03bd\u03bf\u03c5\u03bd \u03cc\u03c4\u03b9 \u03b7 \u03ba\u03b1\u03c4\u03b1\u03bd\u03ac\u03bb\u03c9\u03c3\u03b7 \u03ba\u03b1\u03c6\u03ad \u03c3\u03c4\u03b7 \u03c7\u03ce\u03c1\u03b1 \u03bc\u03b1\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03c4\u03b7\u03c2 \u0395\u03c5\u03c1\u03ce\u03c0\u03b7\u03c2, \u03b5\u03bd \u03c4\u03bf\u03cd\u03c4\u03bf\u03b9\u03c2 \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03bc\u03b9\u03b1 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03b1\u03c5\u03be\u03b7\u03c4\u03b9\u03ba\u03ae \u03c4\u03ac\u03c3\u03b7, \u03b1\u03c6\u03bf\u03cd \u03c4\u03b1 \u03c4\u03b5\u03bb\u03b5\u03c5\u03c4\u03b1\u03af\u03b1 50 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 \u03c0\u03b5\u03bd\u03c4\u03b1\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03c4\u03b5\u03af (\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 1).<\/p>\n

\n

\"18-11-image1\"<\/p>\n

\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 1<\/em>. <\/b>\u0394\u03b9\u03b1\u03c7\u03c1\u03bf\u03bd\u03b9\u03ba\u03ae \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ae \u03c4\u03b7\u03c2 \u03c0\u03b1\u03c1\u03bf\u03c7\u03ae\u03c2 \u03ba\u03b1\u03c6\u03ad (\u03ba\u03b9\u03bb\u03ac\/\u03ac\u03c4\u03bf\u03bc\u03bf\/\u03ad\u03c4\u03bf\u03c2) \u03c3\u03c4\u03b7\u03bd \u0395\u03bb\u03bb\u03ac\u03b4\u03b1 \u03ba\u03b1\u03c4\u03ac \u03c4\u03bf \u03c7\u03c1\u03bf\u03bd\u03b9\u03ba\u03cc \u03b4\u03b9\u03ac\u03c3\u03c4\u03b7\u03bc\u03b1 1961 \u03ad\u03c9\u03c2 2009.<\/p>\n

\n

\u039f\u03b9 \u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c6\u03ad \u03ba\u03b1\u03b9 \u03c4\u03bf\u03c5 \u03ba\u03cd\u03c1\u03b9\u03bf\u03cd \u03c4\u03bf\u03c5 \u03c3\u03c5\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03bf\u03cd, \u03c4\u03b7\u03c2 \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7\u03c2, \u03b5\u03be\u03b1\u03c1\u03c4\u03ce\u03bd\u03c4\u03b1\u03b9 \u03ba\u03b1\u03c4\u03ac \u03c0\u03bf\u03bb\u03cd \u03ba\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf \u03c1\u03c5\u03b8\u03bc\u03cc \u03c4\u03bf\u03c5 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03c3\u03bc\u03bf\u03cd \u03c4\u03bf\u03c5. \u0393\u03b9\u03b1 \u03c0\u03b1\u03c1\u03ac\u03b4\u03b5\u03b9\u03b3\u03bc\u03b1, \u03bf \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03c3\u03bc\u03cc\u03c2 \u03c4\u03b7\u03c2 \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7\u03c2 \u03c3\u03c4\u03b9\u03c2 \u03b3\u03c5\u03bd\u03b1\u03af\u03ba\u03b5\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 20 \u03ad\u03c9\u03c2 30% \u03c4\u03b1\u03c7\u03cd\u03c4\u03b5\u03c1\u03bf\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5\u03c2 \u03ac\u03bd\u03b4\u03c1\u03b5\u03c2. \u03a4\u03b1 \u03b1\u03bd\u03c4\u03b9\u03c3\u03c5\u03bb\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03ac \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5 \u03c3\u03c4\u03cc\u03bc\u03b1\u03c4\u03bf\u03c2 \u03b4\u03b9\u03c0\u03bb\u03b1\u03c3\u03b9\u03ac\u03b6\u03bf\u03c5\u03bd \u03c4\u03bf \u03c7\u03c1\u03cc\u03bd\u03bf\u03c2 \u03b7\u03bc\u03b9\u03c3\u03b5\u03af\u03b1\u03c2 \u03b6\u03c9\u03ae\u03c2 \u03c4\u03b7\u03c2 \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7\u03c2. \u0397 \u03ba\u03cd\u03b7\u03c3\u03b7 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b7\u03bc\u03af\u03c3\u03b5\u03b9\u03b1 \u03b6\u03c9\u03ae \u03c4\u03b7\u03c2 \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7\u03c2 \u03b1\u03c0\u03cc 4 \u03ce\u03c1\u03b5\u03c2 \u03c3\u03c4\u03bf \u03c0\u03c1\u03ce\u03c4\u03bf \u03c4\u03c1\u03af\u03bc\u03b7\u03bd\u03bf \u03ad\u03c9\u03c2 \u03ba\u03b1\u03b9 15 \u03ce\u03c1\u03b5\u03c2 \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7 \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03c4\u03bf\u03c5 \u03c4\u03c1\u03af\u03c4\u03bf\u03c5 \u03c4\u03c1\u03b9\u03bc\u03ae\u03bd\u03bf\u03c5, \u03ba\u03ac\u03c4\u03b9 \u03c4\u03bf \u03bf\u03c0\u03bf\u03af\u03bf \u03ba\u03ac\u03bd\u03b5\u03b9 \u03b1\u03c0\u03b1\u03b3\u03bf\u03c1\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03c4\u03b7 \u03bb\u03ae\u03c8\u03b7 \u03ba\u03b1\u03c6\u03ad \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7 \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 \u03ba\u03cd\u03b7\u03c3\u03b7\u03c2. \u039f \u03c7\u03c1\u03cc\u03bd\u03bf\u03c2 \u03b7\u03bc\u03b9\u03b6\u03c9\u03ae\u03c2 \u03c4\u03b7\u03c2 \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7\u03c2 \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03ba\u03b1\u03c4\u03ac 30 \u03ad\u03c9\u03c2 50% \u03c3\u03c4\u03bf\u03c5\u03c2 \u03ba\u03b1\u03c0\u03bd\u03b9\u03c3\u03c4\u03ad\u03c2, \u03b5\u03bd\u03ce \u03b7 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b7 \u03ba\u03b1\u03c4\u03b1\u03bd\u03ac\u03bb\u03c9\u03c3\u03b7 \u03b1\u03bb\u03ba\u03bf\u03cc\u03bb \u03ba\u03b1\u03b9 \u03b7 \u03b7\u03c0\u03b1\u03c4\u03b9\u03ba\u03ae \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03c5\u03be\u03ac\u03bd\u03bf\u03c5\u03bd.<\/p>\n

\u00a0\u03a3\u03c4\u03bf \u03ba\u03b5\u03c6\u03ac\u03bb\u03b1\u03b9\u03bf \u03b1\u03c5\u03c4\u03cc \u03b4\u03b5 \u03b8\u03b1 \u03c5\u03c0\u03ac\u03c1\u03be\u03bf\u03c5\u03bd \u03b1\u03bd\u03b1\u03c6\u03bf\u03c1\u03ad\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c6\u03ad \u03c3\u03c4\u03bf\u03bd \u03bf\u03c3\u03c4\u03b9\u03ba\u03cc \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03c3\u03bc\u03cc \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b1\u03c1\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae \u03c0\u03af\u03b5\u03c3\u03b7 \u03b3\u03b9\u03b1\u03c4\u03af \u03c4\u03b1 \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1 \u03c0\u03b1\u03c1\u03b1\u03c4\u03af\u03b8\u03b5\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b1 \u03b5\u03b9\u03b4\u03b9\u03ba\u03cc\u03c4\u03b5\u03c1\u03b1 \u03ba\u03b5\u03c6\u03ac\u03bb\u03b1\u03b9\u03b1.<\/p>\n

2. \u0397 \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c6\u03ad \u03c3\u03c4\u03bf\u03bd \u03b5\u03bd\u03b5\u03c1\u03b3\u03b5\u03b9\u03b1\u03ba\u03cc \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03c3\u03bc\u03cc \u03ba\u03b1\u03b9 \u03c3\u03c4\u03bf \u03c3\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc \u03b2\u03ac\u03c1\u03bf\u03c2<\/b><\/h4>\n

\u0395\u03af\u03bd\u03b1\u03b9 \u03b3\u03bd\u03c9\u03c3\u03c4\u03cc \u03b1\u03c0\u03cc \u03c4\u03bf 1915 (4) \u03cc\u03c4\u03b9 \u03b7 \u03ba\u03b1\u03c4\u03b1\u03bd\u03ac\u03bb\u03c9\u03c3\u03b7 \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7\u03c2 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b5\u03bd\u03b5\u03c1\u03b3\u03b5\u03b9\u03b1\u03ba\u03ae \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03ba\u03ae \u03b4\u03c1\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03cc\u03bb\u03b5\u03c2 \u03bf\u03b9 \u03bc\u03b5\u03c4\u03ad\u03c0\u03b5\u03b9\u03c4\u03b1 \u03ad\u03c1\u03b5\u03c5\u03bd\u03b5\u03c2 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03b9\u03ce\u03c3\u03b5\u03b9 \u03b1\u03c5\u03c4\u03ae \u03c4\u03b7\u03bd \u03b1\u03c1\u03c7\u03b9\u03ba\u03ae \u03c0\u03b1\u03c1\u03b1\u03c4\u03ae\u03c1\u03b7\u03c3\u03b7 (5).<\/p>\n

\u039f \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc\u03c4\u03b5\u03c1\u03bf\u03c2 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2 \u03b4\u03c1\u03ac\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7\u03c2 \u03c3\u03b5 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03cc \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03bf \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf \u03bc\u03b7 \u03b5\u03ba\u03bb\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc\u03c2 \u03b1\u03bd\u03c4\u03b1\u03b3\u03c9\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2 \u03c4\u03c9\u03bd \u03911<\/sub> \u03ba\u03b1\u03b9 \u03912\u0391<\/sub> \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03c9\u03bd \u03c4\u03b7\u03c2 \u03b1\u03b4\u03b5\u03bd\u03bf\u03c3\u03af\u03bd\u03b7\u03c2.\u0391\u03c5\u03c4\u03bf\u03af \u03bf\u03b9 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03b5\u03af\u03c2 \u03b2\u03c1\u03af\u03c3\u03ba\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03cc\u03bb\u03bf \u03c4\u03bf \u03c3\u03ce\u03bc\u03b1, \u03cc\u03c0\u03c9\u03c2 \u03c3\u03c4\u03bf \u039a\u039d\u03a3, \u03c3\u03c4\u03bf \u03bb\u03b9\u03c0\u03ce\u03b4\u03b7 \u03b9\u03c3\u03c4\u03cc, \u03c3\u03c4\u03bf \u03b1\u03bd\u03b1\u03c0\u03bd\u03b5\u03c5\u03c3\u03c4\u03b9\u03ba\u03cc, \u03c3\u03c4\u03bf \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03cc, \u03c3\u03c4\u03bf \u03b3\u03b1\u03c3\u03c4\u03c1\u03b5\u03bd\u03c4\u03b5\u03c1\u03b9\u03ba\u03cc \u03c3\u03cd\u03c3\u03c4\u03b7\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03bd\u03b5\u03c6\u03c1\u03bf\u03cd\u03c2.\u0391\u03c5\u03c4\u03cc\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf \u03bc\u03cc\u03bd\u03bf\u03c2 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2 \u03b4\u03c1\u03ac\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c3\u03c5\u03bd\u03ae\u03b8\u03b7 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03b1\u03c5\u03c4\u03ae\u03c2 \u03c3\u03c4\u03bf \u03b1\u03af\u03bc\u03b1 \u03c0\u03bf\u03c5 \u03b5\u03c0\u03b9\u03c4\u03c5\u03b3\u03c7\u03ac\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03ad\u03c3\u03c9 \u03c4\u03b7\u03c2 \u03c0\u03c1\u03cc\u03c3\u03bb\u03b7\u03c8\u03ae\u03c2 \u03c4\u03b7\u03c2 \u03b1\u03c0\u03cc \u03b4\u03b9\u03b1\u03b9\u03c4\u03b7\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b7\u03b3\u03ad\u03c2 (6).<\/p>\n

\u0397 \u03b1\u03b4\u03b5\u03bd\u03bf\u03c3\u03af\u03bd\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1\u03c2 \u03b1\u03bd\u03b1\u03c3\u03c4\u03b1\u03bb\u03c4\u03b9\u03ba\u03cc\u03c2 \u03bd\u03b5\u03c5\u03c1\u03bf\u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03c4\u03b9\u03ba\u03cc\u03c2 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1\u03c2.\u039f\u03b9 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03b5\u03af\u03c2 \u03c4\u03b7\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 G-\u03c3\u03c5\u03bd\u03b5\u03b6\u03b5\u03c5\u03b3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd \u03c4\u03b7\u03bd \u03b1\u03b4\u03b5\u03bd\u03c5\u03bb\u03b9\u03ba\u03ae \u03ba\u03c5\u03ba\u03bb\u03ac\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae cAMP.<\/p>\n

\u0395\u03bd\u03ce \u03bf\u03b9 \u03911<\/sub> \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03b5\u03af\u03c2 \u03c4\u03b7\u03c2 \u03b1\u03b4\u03b5\u03bd\u03bf\u03c3\u03af\u03bd\u03b7\u03c2 \u03b2\u03c1\u03af\u03c3\u03ba\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03cc\u03bb\u03bf \u03c4\u03bf\u03bd \u03b5\u03b3\u03ba\u03ad\u03c6\u03b1\u03bb\u03bf, \u03bf\u03b9 \u03912\u0391<\/sub> \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03b5\u03af\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c5\u03b3\u03ba\u03b5\u03bd\u03c4\u03c1\u03c9\u03bc\u03ad\u03bd\u03bf\u03b9 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03bd\u03c4\u03bf\u03c0\u03b1\u03bc\u03b9\u03bd\u03b5\u03c1\u03b3\u03b9\u03ba\u03bf\u03cd\u03c2 \u03bd\u03b5\u03c5\u03c1\u03ce\u03bd\u03b5\u03c2 \u03c4\u03bf\u03c5 \u03c1\u03b1\u03b2\u03b4\u03c9\u03c4\u03bf\u03cd \u03c3\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c3\u03c4\u03b1 \u03b2\u03b1\u03c3\u03b9\u03ba\u03ac \u03b3\u03ac\u03b3\u03b3\u03bb\u03b9\u03b1 \u03c4\u03bf\u03c5 \u039a\u039d\u03a3.<\/p>\n

\u0397 \u03b1\u03b4\u03b5\u03bd\u03bf\u03c3\u03af\u03bd\u03b7, \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7 \u03c3\u03cd\u03bd\u03b4\u03b5\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03c4\u03b7\u03c2, \u03b4\u03c1\u03b1 \u03c0\u03c1\u03bf\u03c3\u03c5\u03bd\u03b1\u03c0\u03c4\u03b9\u03ba\u03ac \u03b1\u03bd\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7\u03bd \u03b1\u03c0\u03b5\u03bb\u03b5\u03c5\u03b8\u03ad\u03c1\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03bd\u03b5\u03c5\u03c1\u03bf\u03bc\u03b5\u03c4\u03b1\u03b2\u03b9\u03b2\u03b1\u03c3\u03c4\u03ce\u03bd \u03b1\u03ba\u03b5\u03c4\u03c5\u03bb\u03bf\u03c7\u03bf\u03bb\u03af\u03bd\u03b7\u03c2, \u03bd\u03bf\u03c1\u03b5\u03c0\u03b9\u03bd\u03b5\u03c6\u03c1\u03af\u03bd\u03b7\u03c2, \u03bd\u03c4\u03bf\u03c0\u03b1\u03bc\u03af\u03bd\u03b7\u03c2, \u03b3\u03ac\u03bc\u03b1 \u03b1\u03bc\u03b9\u03bd\u03bf-\u03b2\u03bf\u03c5\u03c4\u03c5\u03c1\u03b9\u03ba\u03bf\u03cd \u03bf\u03be\u03ad\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03b5\u03c1\u03bf\u03c4\u03bf\u03bd\u03af\u03bd\u03b7\u03c2.<\/p>\n

\u0397 \u03c3\u03cd\u03bd\u03b4\u03b5\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7\u03c2 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03912\u0391 <\/sub>\u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03b1\u03bd\u03b1\u03c4\u03c1\u03ad\u03c0\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b1\u03bd\u03b1\u03c3\u03c4\u03b1\u03bb\u03c4\u03b9\u03ba\u03ae \u03b4\u03c1\u03ac\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03b4\u03b5\u03bd\u03bf\u03c3\u03af\u03bd\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03ad\u03c4\u03c3\u03b9 \u03ad\u03c7\u03bf\u03c5\u03bc\u03b5 \u03b1\u03c0\u03b5\u03bb\u03b5\u03c5\u03b8\u03ad\u03c1\u03c9\u03c3\u03b7 \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03bd\u03b5\u03c5\u03c1\u03b9\u03ba\u03ad\u03c2 \u03b1\u03c0\u03bf\u03bb\u03ae\u03be\u03b5\u03b9\u03c2 \u03c3\u03b5\u03c1\u03bf\u03c4\u03bf\u03bd\u03af\u03bd\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03ba\u03b1\u03c4\u03b5\u03c7\u03bf\u03bb\u03b1\u03bc\u03b9\u03bd\u03ce\u03bd (\u03bd\u03bf\u03c1\u03b5\u03c0\u03b9\u03bd\u03b5\u03c6\u03c1\u03af\u03bd\u03b7, \u03b5\u03c0\u03b9\u03bd\u03b5\u03c6\u03c1\u03af\u03bd\u03b7 \u03ba\u03b1\u03b9 \u03bd\u03c4\u03bf\u03c0\u03b1\u03bc\u03af\u03bd\u03b7) \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03b7\u03bd \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03b1\u03c5\u03c4\u03ce\u03bd \u03c3\u03c4\u03bf \u039a\u039d\u03a3 \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03c3\u03c4\u03bf \u03c0\u03b5\u03c1\u03b9\u03c6\u03b5\u03c1\u03b9\u03ba\u03cc \u03b1\u03af\u03bc\u03b1 (7).<\/p>\n

\u0386\u03bb\u03bb\u03bf\u03b9 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03af \u03b4\u03c1\u03ac\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7\u03c2, \u03c0\u03bf\u03c5 \u03cc\u03bc\u03c9\u03c2 \u03b1\u03c0\u03b1\u03b9\u03c4\u03bf\u03cd\u03bd \u03c3\u03c5\u03b3\u03ba\u03b5\u03bd\u03c4\u03c1\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c0\u03bf\u03c5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03ac\u03bb\u03bb\u03bf\u03bd \u03c4\u03bf\u03be\u03b9\u03ba\u03ad\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03ac\u03bd\u03b8\u03c1\u03c9\u03c0\u03bf \u03b5\u03af\u03bd\u03b1\u03b9:<\/p>\n

    \n
  • H \u03b1\u03bd\u03c4\u03b1\u03b3\u03c9\u03bd\u03b9\u03c3\u03c4\u03b9\u03ba\u03ae \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03c9\u03bd \u03c6\u03c9\u03c3\u03c6\u03bf\u03b4\u03b9\u03b5\u03c3\u03c4\u03b5\u03c1\u03b1\u03c3\u03ce\u03bd \u03c4\u03c9\u03bd \u03ba\u03c5\u03ba\u03bb\u03b9\u03ba\u03ce\u03bd \u03bd\u03bf\u03c5\u03ba\u03bb\u03b5\u03bf\u03c4\u03b9\u03b4\u03af\u03c9\u03bd, \u03c4\u03b1 \u03bf\u03c0\u03bf\u03af\u03b1 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03af\u03b6\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd cAMP. \u0391\u03c5\u03c4\u03ae \u03b7 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c3\u03c5\u03bc\u03b2\u03b1\u03af\u03bd\u03b5\u03b9 \u03bb\u03cc\u03b3\u03c9 \u03c4\u03b7\u03c2 \u03bf\u03bc\u03bf\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c4\u03b7\u03c2 \u03b4\u03bf\u03bc\u03ae\u03c2 \u03c4\u03b7\u03c2 \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7\u03c2 \u03bc\u03b5 \u03c4\u03b7\u03bd cAMP.<\/li>\n
  • \u0397 \u03ac\u03bc\u03b5\u03c3\u03b7 \u03b1\u03c0\u03b5\u03bb\u03b5\u03c5\u03b8\u03ad\u03c1\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b5\u03bd\u03b4\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03b9\u03bf\u03c5 \u03b1\u03c3\u03b2\u03b5\u03c3\u03c4\u03af\u03bf\u03c5 \u03bc\u03ad\u03c3\u03c9 \u03c4\u03b7\u03c2 \u03b4\u03c1\u03ac\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7\u03c2 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03b5\u03af\u03c2 \u03c1\u03c5\u03b1\u03bd\u03bf\u03b4\u03af\u03bd\u03b7\u03c2.<\/li>\n<\/ul>\n

    \u0397 \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7 \u03c3\u03c4\u03b7 \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03c4\u03b7\u03c2 \u03bc\u03bf\u03c1\u03c6\u03ae \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b5\u03c2 \u03b4\u03cc\u03c3\u03b5\u03b9\u03c2 (8 mg\/\u03ba\u03bb. \u03c3\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03bf\u03cd \u03b2\u03ac\u03c1\u03bf\u03c5\u03c2, \u03b9\u03c3\u03bf\u03b4\u03cd\u03bd\u03b1\u03bc\u03bf \u03bc\u03b5 5-6 \u03c6\u03bb\u03b9\u03c4\u03b6\u03ac\u03bd\u03b9\u03b1 \u03ba\u03b1\u03c6\u03ad) \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03bf\u03be\u03ad\u03c9\u03c2 \u03c4\u03bf\u03bd \u03b5\u03bd\u03b5\u03c1\u03b3\u03b5\u03b9\u03b1\u03ba\u03cc \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03c3\u03bc\u03cc \u03ba\u03b1\u03c4\u03ac 16% \u03c3\u03b5 \u03bb\u03b5\u03c0\u03c4\u03cc\u03c3\u03c9\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03c0\u03b1\u03c7\u03cd\u03c3\u03b1\u03c1\u03ba\u03b1 \u03ac\u03c4\u03bf\u03bc\u03b1, \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03bf\u03be\u03b5\u03af\u03b4\u03c9\u03c3\u03b7 \u03bb\u03af\u03c0\u03bf\u03c5\u03c2 \u03c3\u03b5 \u03b2\u03ac\u03c1\u03bf\u03c2 \u03c4\u03c9\u03bd \u03c5\u03b4\u03b1\u03c4\u03b1\u03bd\u03b8\u03c1\u03ac\u03ba\u03c9\u03bd, \u03bc\u03cc\u03bd\u03bf \u03cc\u03bc\u03c9\u03c2 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03bd\u03bf\u03c1\u03bc\u03bf\u03b2\u03b1\u03c1\u03b5\u03af\u03c2 (5). \u0391\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03bc\u03b9\u03ba\u03c1\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03b4\u03cc\u03c3\u03b5\u03b9\u03c2 \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7\u03c2 (4 mg\/\u03ba\u03bb. \u03c3\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03bf\u03cd \u03b2\u03ac\u03c1\u03bf\u03c5\u03c2, \u03b9\u03c3\u03bf\u03b4\u03cd\u03bd\u03b1\u03bc\u03bf \u03bc\u03b5 2-3 \u03c6\u03bb\u03b9\u03c4\u03b6\u03ac\u03bd\u03b9\u03b1 \u03ba\u03b1\u03c6\u03ad) \u03c5\u03c0\u03cc \u03c4\u03b7\u03bd \u03bc\u03bf\u03c1\u03c6\u03ae \u03ba\u03b1\u03c6\u03ad \u03c6\u03af\u03bb\u03c4\u03c1\u03bf\u03c5, \u03bc\u03b5 \u03ae \u03ba\u03b1\u03b9 \u03c7\u03c9\u03c1\u03af\u03c2 \u03c0\u03c1\u03cc\u03b3\u03b5\u03c5\u03bc\u03b1, \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03b7 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03ba\u03ae \u03b4\u03c1\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u03ba\u03b1\u03c4\u03ac \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 12% \u03bc\u03ad\u03c7\u03c1\u03b9 \u03ba\u03b1\u03b9 3 \u03ce\u03c1\u03b5\u03c2 \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7\u03bd \u03ba\u03b1\u03c4\u03b1\u03bd\u03ac\u03bb\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b1\u03c6\u03b5\u03c8\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2 (5).<\/p>\n

    \u039c\u03b5\u03c4\u03b1-\u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7, \u03b1\u03bd\u03b1\u03c6\u03bf\u03c1\u03b9\u03ba\u03ac \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7\u03c2 \u03c3\u03c4\u03b7\u03bd 24\u03c9\u03c1\u03b7 \u03b8\u03b5\u03c1\u03bc\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7, \u03ad\u03b4\u03b5\u03b9\u03be\u03b5 \u03cc\u03c4\u03b9 \u03b7 \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03ae \u03c4\u03b7\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b4\u03bf\u03c3\u03bf\u03b5\u03be\u03b1\u03c1\u03c4\u03ce\u03bc\u03b5\u03bd\u03b7 \u03ba\u03b1\u03b9 \u03ba\u03c5\u03bc\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 \u03c3\u03c4\u03b9\u03c2 0.24 Kcal \u03b1\u03bd\u03ac 1 mg \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7\u03c2 (8), \u03b4\u03b7\u03bb\u03b1\u03b4\u03ae \u03b3\u03b9\u03b1 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 24\u03c9\u03c1\u03b7\u03c2 \u03b5\u03bd\u03b5\u03c1\u03b3\u03b5\u03b9\u03b1\u03ba\u03ae\u03c2 \u03ba\u03b1\u03c4\u03b1\u03bd\u03ac\u03bb\u03c9\u03c3\u03b7\u03c2 \u03ba\u03b1\u03c4\u03ac 150 Kcal \u03b8\u03b1 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03ba\u03b1\u03bd\u03b5\u03af\u03c2 \u03bd\u03b1 \u03c0\u03af\u03bd\u03b5\u03b9 6 \u03b4\u03c5\u03bd\u03b1\u03c4\u03bf\u03cd\u03c2 \u03ba\u03b1\u03c6\u03ad\u03b4\u03b5\u03c2 \u03ba\u03ac\u03b8\u03b5 \u03bc\u03ad\u03c1\u03b1.<\/p>\n

    \u0397 \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9, \u03b5\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd \u03ba\u03b1\u03b9 \u03ad\u03bd\u03b1 \u03b5\u03c1\u03b3\u03bf\u03b3\u03bf\u03bd\u03b9\u03ba\u03cc \u03b2\u03bf\u03ae\u03b8\u03b7\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03b7 \u03c3\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b4\u03c1\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c3\u03b5 \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03b1\u03b8\u03bb\u03bf\u03cd\u03bc\u03b5\u03bd\u03bf\u03c5\u03c2 \u03ba\u03b1\u03b9 \u03cc\u03c7\u03b9. \u039b\u03ae\u03c8\u03b7 \u03c0\u03c1\u03bf \u03c4\u03b7\u03c2 \u03ac\u03c3\u03ba\u03b7\u03c3\u03b7\u03c2 4.5 mg\/\u03ba\u03bb \u03a3\u0392 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03b7 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03ba\u03ae \u03b4\u03c1\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u03ba\u03b1\u03c4\u03ac \u03b1\u03bb\u03bb\u03ac \u03b1\u03ba\u03cc\u03bc\u03b1 \u03ba\u03b1\u03b9 3 \u03ce\u03c1\u03b5\u03c2 \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7\u03bd \u03ac\u03c3\u03ba\u03b7\u03c3\u03b7 (9).<\/p>\n

    \u0395\u03ba\u03c4\u03cc\u03c2 \u03cc\u03bc\u03c9\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b8\u03b5\u03c1\u03bc\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7\u03c2, \u03b7 \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03ba\u03b9\u03bd\u03b7\u03c4\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03bf\u03be\u03b5\u03af\u03b4\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03bb\u03af\u03c0\u03bf\u03c5\u03c2, \u03ba\u03ac\u03c4\u03b9 \u03c0\u03bf\u03bb\u03cd \u03b5\u03c0\u03b9\u03b8\u03c5\u03bc\u03b7\u03c4\u03cc, \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03cc\u03c4\u03b1\u03bd \u03b5\u03c0\u03b9\u03b4\u03b9\u03ce\u03ba\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1 \u03b2\u03ac\u03c1\u03bf\u03c5\u03c2.<\/p>\n

    \u03a0\u03bf\u03bb\u03bb\u03ad\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c3\u03c4\u03bf\u03bd \u03ac\u03bd\u03b8\u03c1\u03c9\u03c0\u03bf \u03ad\u03b4\u03b5\u03b9\u03be\u03b1\u03bd \u03cc\u03c4\u03b9 \u03b7 \u03bb\u03ae\u03c8\u03b7 \u03ba\u03b1\u03c6\u03ad \u03bc\u03b5 \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7 \u03c3\u03c4\u03b9\u03c2 \u03c3\u03c5\u03bd\u03ae\u03b8\u03b5\u03b9\u03c2 \u03c0\u03bf\u03c3\u03cc\u03c4\u03b7\u03c4\u03b5\u03c2 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03b7 \u03bb\u03b9\u03c0\u03cc\u03bb\u03c5\u03c3\u03b7.\u03a9\u03c2 \u03b4\u03b5\u03af\u03ba\u03c4\u03b7\u03c2 \u03bb\u03b9\u03c0\u03cc\u03bb\u03c5\u03c3\u03b7\u03c2 \u03b5\u03bb\u03ae\u03c6\u03b8\u03b7\u03c3\u03b1\u03bd \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03b3\u03bb\u03c5\u03ba\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2 \u03c3\u03c4\u03bf \u03c0\u03bb\u03ac\u03c3\u03bc\u03b1, \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03ac\u03bb\u03bb\u03c9\u03c3\u03c4\u03b5 \u03b8\u03b5\u03c9\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03bf \u03c0\u03bb\u03ad\u03bf\u03bd \u03b1\u03bd\u03c4\u03b9\u03ba\u03b5\u03b9\u03bc\u03b5\u03bd\u03b9\u03ba\u03cc\u03c2 \u03b4\u03b5\u03af\u03ba\u03c4\u03b7\u03c2 \u03bb\u03b9\u03c0\u03cc\u03bb\u03c5\u03c3\u03b7\u03c2 (10).\u0391\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03b4\u03b5\u03bd \u03c5\u03c0\u03ae\u03c1\u03be\u03b1\u03bd \u03cc\u03c4\u03b1\u03bd \u03c7\u03bf\u03c1\u03b7\u03b3\u03ae\u03b8\u03b7\u03ba\u03b5 \u03ba\u03b1\u03c6\u03ad\u03c2 \u03c7\u03c9\u03c1\u03af\u03c2 \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7, \u03ba\u03ac\u03c4\u03b9 \u03c4\u03bf \u03bf\u03c0\u03bf\u03af\u03bf \u03c5\u03c0\u03bf\u03b4\u03b7\u03bb\u03ce\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03b7 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bb\u03b9\u03c0\u03cc\u03bb\u03c5\u03c3\u03b7\u03c2 \u03bf\u03c6\u03b5\u03af\u03bb\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7 \u03ba\u03b1\u03b9 \u03cc\u03c7\u03b9 \u03c3\u03b5 \u03ac\u03bb\u03bb\u03b1 \u03c3\u03c5\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03ac \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c6\u03ad (11).<\/p>\n

    \u03a3\u03b5 \u03bc\u03b1\u03ba\u03c1\u03bf\u03c7\u03c1\u03cc\u03bd\u03b9\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c3\u03b5 \u03c4\u03c1\u03c9\u03ba\u03c4\u03b9\u03ba\u03ac \u03b4\u03b5\u03af\u03c7\u03c4\u03b7\u03ba\u03b5 \u03cc\u03c4\u03b9 \u03b7 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7\u03c2 \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03bf \u03bc\u03ad\u03b3\u03b5\u03b8\u03bf\u03c2 \u03c4\u03c9\u03bd \u03bb\u03b9\u03c0\u03bf\u03b1\u03c0\u03bf\u03b8\u03b7\u03ba\u03ce\u03bd \u03ba\u03b1\u03b9 \u03c4\u03bf\u03bd \u03b1\u03c1\u03b9\u03b8\u03bc\u03cc \u03c4\u03c9\u03bd \u03bb\u03b9\u03c0\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd (12).\u0391\u03c5\u03c4\u03cc \u03b5\u03c0\u03b9\u03c4\u03c5\u03b3\u03c7\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03ad\u03c3\u03c9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2 \u03c4\u03b7\u03c2 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd \u03b2\u03bb\u03b1\u03c3\u03c4\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c0\u03c1\u03bf\u03c2 \u03ce\u03c1\u03b9\u03bc\u03b1 \u03bb\u03b9\u03c0\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1, \u03cc\u03c0\u03c9\u03c2 \u03ad\u03b4\u03b5\u03b9\u03be\u03b5 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03c3\u03b5 \u03ba\u03b1\u03bb\u03bb\u03b9\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2 \u03b1\u03c1\u03c7\u03ad\u03b3\u03bf\u03bd\u03c9\u03bd \u03b2\u03bb\u03b1\u03c3\u03c4\u03b9\u03ba\u03ce\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c0\u03c1\u03bf\u03b5\u03c1\u03c7\u03cc\u03bc\u03b5\u03bd\u03c9\u03bd \u03b1\u03c0\u03cc \u03bb\u03b9\u03c0\u03ce\u03b4\u03b7 \u03b9\u03c3\u03c4\u03cc \u03b1\u03c1\u03bf\u03c5\u03c1\u03b1\u03af\u03bf\u03c5 (13).<\/p>\n

    \u039f \u03ba\u03b1\u03c6\u03ad\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b1\u03c5\u03be\u03ae\u03c3\u03b5\u03b9 \u03c4\u03b7 \u03b8\u03b5\u03c1\u03bc\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bf\u03be\u03b5\u03af\u03b4\u03c9\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03bb\u03af\u03c0\u03bf\u03c5\u03c2.<\/p>\n

    \u03a7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c9\u03c2 \u03b4\u03b5\u03af\u03ba\u03c4\u03b7 \u03c4\u03b7 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b1\u03bd\u03b1\u03c0\u03bd\u03b5\u03c5\u03c3\u03c4\u03b9\u03ba\u03cc \u03c0\u03b7\u03bb\u03af\u03ba\u03bf\u03c5, \u03c0\u03bf\u03bb\u03bb\u03bf\u03af \u03b1\u03bb\u03bb\u03ac \u03cc\u03c7\u03b9 \u03cc\u03bb\u03bf\u03b9 \u03bf\u03b9 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03ad\u03c2, \u03ba\u03b1\u03c4\u03ad\u03bb\u03b7\u03be\u03b1\u03bd \u03c3\u03c4\u03bf \u03c3\u03c5\u03bc\u03c0\u03ad\u03c1\u03b1\u03c3\u03bc\u03b1\u00a0 \u03cc\u03c4\u03b9 \u03b7 \u03ba\u03b1\u03c4\u03b1\u03bd\u03ac\u03bb\u03c9\u03c3\u03b7 \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7\u03c2 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b1\u03bd\u03b1\u03bb\u03bf\u03b3\u03af\u03b1 \u03bf\u03be\u03b5\u03af\u03b4\u03c9\u03c3\u03b7 \u03bb\u03af\u03c0\u03bf\u03c5\u03c2 (14, 15), \u03b1\u03bb\u03bb\u03ac \u03b4\u03c5\u03c3\u03c4\u03c5\u03c7\u03ce\u03c2 \u03c4\u03bf \u03c6\u03b1\u03b9\u03bd\u03cc\u03bc\u03b5\u03bd\u03bf \u03b1\u03c5\u03c4\u03cc \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c3\u03c4\u03b1 \u03bb\u03b5\u03c0\u03c4\u03cc\u03c3\u03c9\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03bc\u03ac\u03bb\u03bb\u03bf\u03bd \u03cc\u03c7\u03b9 \u03c3\u03c4\u03b1 \u03c0\u03b1\u03c7\u03cd\u03c3\u03b1\u03c1\u03ba\u03b1 \u03ac\u03c4\u03bf\u03bc\u03b1.<\/p>\n

    \u03a0\u03c1\u03cc\u03c3\u03c6\u03b1\u03c4\u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03bf\u03bc\u03ac\u03b4\u03b1 \u03c4\u03bf\u03c5 \u03a7. \u039c\u03b1\u03bd\u03c4\u03b6\u03ce\u03c1\u03bf\u03c5 (16), \u03ad\u03b4\u03b5\u03b9\u03be\u03b5 \u03cc\u03c4\u03b9 \u03c3\u03b5 \u03c0\u03b1\u03c7\u03cd\u03c3\u03b1\u03c1\u03ba\u03b1 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03bc\u03b9\u03b1 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5\u03b3\u03ac\u03bb\u03b7 \u03b5\u03c6\u03ac\u03c0\u03b1\u03be \u03c0\u03bf\u03c3\u03cc\u03c4\u03b7\u03c4\u03b1 \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7\u03c2 (\u03ba\u03b1\u03c6\u03ad\u03c2 \u03bc\u03b5 6 mg \u03ba\u03b1\u03c6\u03b5\u03af\u03bd\u03b7\u03c2\/\u03ba\u03bb \u03a3\u0392) \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03c4\u03b7\u03bd \u03c0\u03bf\u03c3\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03c1\u03bf\u03c6\u03ae\u03c2, \u03cc\u03c7\u03b9 \u03bc\u03cc\u03bd\u03bf \u03c4\u03bf\u03c5 \u03b5\u03c0\u03cc\u03bc\u03b5\u03bd\u03bf\u03c5 \u03b3\u03b5\u03cd\u03bc\u03b1\u03c4\u03bf\u03c2, \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03cc\u03bb\u03b7 \u03c4\u03b7\u03bd \u03b5\u03c0\u03cc\u03bc\u03b5\u03bd\u03b7 \u03bc\u03ad\u03c1\u03b1, \u03c7\u03c9\u03c1\u03af\u03c2 \u03bd\u03b1 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03cc\u03c1\u03b5\u03be\u03b7.\u0392\u03ad\u03b2\u03b1\u03b9\u03b1, \u03c3\u03b5 \u03ac\u03bb\u03bb\u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03b4\u03b5\u03af\u03c7\u03c4\u03b7\u03ba\u03b5 \u03cc\u03c4\u03b9 \u03bf \u03ba\u03b1\u03c6\u03ad\u03c2 \u03c7\u03c9\u03c1\u03af\u03c2 \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7 \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03cc\u03c1\u03b5\u03be\u03b7 \u03bc\u03ad\u03c3\u03c9 \u03c4\u03b7\u03c2 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03c0\u03b5\u03c0\u03c4\u03b9\u03b4\u03af\u03bf\u03c5 \u03a5\u03a5, \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae\u03c2 \u03bf\u03c1\u03bc\u03cc\u03bd\u03b7\u03c2 \u03ba\u03bf\u03c1\u03b5\u03c3\u03bc\u03bf\u03cd (17).<\/p>\n

    \u03a3\u03c5\u03bd\u03bf\u03c0\u03c4\u03b9\u03ba\u03ac, \u03c4\u03b1 \u03b5\u03c5\u03c1\u03ae\u03bc\u03b1\u03c4\u03b1 \u03b1\u03c5\u03c4\u03ac \u03c5\u03c0\u03bf\u03b4\u03b7\u03bb\u03ce\u03bd\u03bf\u03c5\u03bd \u03cc\u03c4\u03b9 \u03b7 \u03ba\u03b1\u03c4\u03b1\u03bd\u03ac\u03bb\u03c9\u03c3\u03b7 \u03ba\u03b1\u03c6\u03ad \u03b8\u03b1 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03c3\u03b5 \u03b8\u03b5\u03c9\u03c1\u03b7\u03c4\u03b9\u03ba\u03ac \u03bd\u03b1 \u03b2\u03bf\u03b7\u03b8\u03ae\u03c3\u03b5\u03b9 \u03c4\u03b1 \u03c0\u03b1\u03c7\u03cd\u03c3\u03b1\u03c1\u03ba\u03b1 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03bd\u03b1 \u03c7\u03ac\u03c3\u03bf\u03c5\u03bd \u03b2\u03ac\u03c1\u03bf\u03c2 \u03bc\u03ad\u03c3\u03c9 \u03c4\u03b7\u03c2 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03b8\u03b5\u03c1\u03bc\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7\u03c2, \u03c4\u03b7\u03c2 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd \u03bb\u03b9\u03c0\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd, \u03c4\u03b7\u03c2 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03bb\u03b9\u03c0\u03cc\u03bb\u03c5\u03c3\u03b7\u03c2, \u03c4\u03b7\u03c2 \u03b1\u03bd\u03b1\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae\u03c2 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03bf\u03be\u03b5\u03af\u03b4\u03c9\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03bb\u03af\u03c0\u03bf\u03c5\u03c2, \u03c4\u03b7\u03c2 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03c3\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03c0\u03bf\u03c3\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c4\u03b7\u03c2 \u03c0\u03c1\u03bf\u03c3\u03bb\u03b1\u03bc\u03b2\u03b1\u03bd\u03cc\u03bc\u03b5\u03bd\u03b7\u03c2 \u03c4\u03c1\u03bf\u03c6\u03ae\u03c2.<\/p>\n

    3. \u0397 \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c6\u03ad \u03c3\u03c4\u03bf \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03c3\u03bc\u03cc \u03c4\u03c9\u03bd \u03c5\u03b4\u03b1\u03c4\u03b1\u03bd\u03b8\u03c1\u03ac\u03ba\u03c9\u03bd <\/b><\/h4>\n

    \u03a3\u03b5 \u03bc\u03b5\u03b3\u03ac\u03bb\u03bf \u03b1\u03c1\u03b9\u03b8\u03bc\u03cc \u03b5\u03c0\u03b9\u03b4\u03b7\u03bc\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ce\u03bd \u03bc\u03b5\u03bb\u03b5\u03c4\u03ce\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2 \u03cc\u03c4\u03b9 \u03b7 \u03ba\u03b1\u03c4\u03b1\u03bd\u03ac\u03bb\u03c9\u03c3\u03b7 \u03ba\u03b1\u03c6\u03ad \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bc\u03b5\u03b9\u03ce\u03c3\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7\u03c2 \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7 2, \u03ae \u03bd\u03b1 \u03b2\u03b5\u03bb\u03c4\u03b9\u03ce\u03c3\u03b5\u03b9 \u03c4\u03bf\u03c5\u03c2 \u03b4\u03b5\u03af\u03ba\u03c4\u03b5\u03c2 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03c3\u03bc\u03bf\u03cd \u03c4\u03c9\u03bd \u03c5\u03b4\u03b1\u03c4\u03b1\u03bd\u03b8\u03c1\u03ac\u03ba\u03c9\u03bd \u03ae \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03b4\u03cd\u03bf.\u03a0\u03ac\u03bd\u03c4\u03c9\u03c2, \u03b1\u03bd \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03bc\u03b5\u03c1\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03b4\u03b5\u03bd \u03c6\u03ac\u03bd\u03b7\u03ba\u03b1\u03bd \u03b5\u03c5\u03bd\u03bf\u03ca\u03ba\u03ad\u03c2 \u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2, \u03c3\u03b5 \u03ba\u03b1\u03bc\u03b9\u03ac \u03b4\u03b5\u03bd \u03c5\u03c0\u03ae\u03c1\u03be\u03b1\u03bd \u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2 \u03cc\u03c4\u03b9 \u03b7 \u03c3\u03c5\u03bd\u03ae\u03b8\u03b7\u03c2 \u03ba\u03b1\u03c4\u03b1\u03bd\u03ac\u03bb\u03c9\u03c3\u03b7 \u03ba\u03b1\u03c6\u03ad \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03c0\u03b9\u03b2\u03b1\u03c1\u03c5\u03bd\u03c4\u03b9\u03ba\u03cc\u03c2 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1\u03c2.<\/p>\n

    \u039c\u03b5\u03c4\u03b1-\u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 18 \u03c0\u03c1\u03bf\u03bf\u03c0\u03c4\u03b9\u03ba\u03ce\u03bd \u03bc\u03b5\u03bb\u03b5\u03c4\u03ce\u03bd \u03ad\u03b4\u03b5\u03b9\u03be\u03b5 \u03cc\u03c4\u03b9 \u03b7 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b7 \u03ba\u03b1\u03c4\u03b1\u03bd\u03ac\u03bb\u03c9\u03c3\u03b7 \u03ba\u03b1\u03c6\u03ad (>4 \u03c6\u03bb\u03b9\u03c4\u03b6\/\u03b7\u03bc), \u03c3\u03b5 \u03c3\u03c7\u03ad\u03c3\u03b7 \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c5\u03c3\u03af\u03b1 \u03ae \u03bc\u03b9\u03ba\u03c1\u03ae \u03ba\u03b1\u03c4\u03b1\u03bd\u03ac\u03bb\u03c9\u03c3\u03b7 (<2 \u03c6\u03bb\u03b9\u03c4\u03b6\u03b1\u03bd\u03b9\u03ce\u03bd \u03c4\u03b7\u03bd \u03b7\u03bc\u03ad\u03c1\u03b1), \u03c3\u03c5\u03c3\u03c7\u03b5\u03c4\u03af\u03c3\u03b8\u03b7\u03ba\u03b5 \u03bc\u03b5 25% \u03bc\u03b9\u03ba\u03c1\u03cc\u03c4\u03b5\u03c1\u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7\u03c2 \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7 2 (18) \u03ba\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03c3\u03c4\u03bf\u03bd \u0395\u03bb\u03bb\u03b7\u03bd\u03b9\u03ba\u03cc \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03cc \u03ad\u03b4\u03b5\u03b9\u03be\u03b5 \u03cc\u03c4\u03b9 \u03b7 \u03bc\u03ad\u03c4\u03c1\u03b9\u03b1 \u03ba\u03b1\u03c4\u03b1\u03bd\u03ac\u03bb\u03c9\u03c3\u03b7 \u03ba\u03b1\u03c6\u03ad (1-2 \u03c6\u03bb\u03b9\u03c4\u03b6\/\u03b7\u03bc.), \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03bc\u03b9\u03ba\u03c1\u03cc\u03c4\u03b5\u03c1\u03b7 \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7\u03c2 \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7 2 \u03c3\u03b5 \u03b7\u03bb\u03b9\u03ba\u03b9\u03c9\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2 \u03c0\u03bf\u03c5 \u03b6\u03bf\u03c5\u03bd \u03c3\u03b5 \u03bd\u03b7\u03c3\u03b9\u03ac \u03c4\u03b7\u03c2 \u039c\u03b5\u03c3\u03bf\u03b3\u03b5\u03af\u03bf\u03c5 (19).<\/p>\n

    \u03a4\u03bf \u03b5\u03bd\u03b4\u03b9\u03b1\u03c6\u03ad\u03c1\u03bf\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03cc\u03c4\u03b9 4 \u03c0\u03c1\u03bf\u03bf\u03c0\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03ad\u03b4\u03b5\u03b9\u03be\u03b1\u03bd \u03cc\u03c4\u03b9 \u03b1\u03ba\u03cc\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03bf \u03ba\u03b1\u03c6\u03ad\u03c2 \u03c7\u03c9\u03c1\u03af\u03c2 \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7 \u03b1\u03c3\u03ba\u03b5\u03af \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b7 \u03c0\u03c1\u03bf\u03c3\u03c4\u03b1\u03c4\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03b4\u03c1\u03ac\u03c3\u03b7, \u03ba\u03ac\u03c4\u03b9 \u03c4\u03bf \u03bf\u03c0\u03bf\u03af\u03bf \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03c4\u03bf \u03c3\u03c5\u03bc\u03c0\u03ad\u03c1\u03b1\u03c3\u03bc\u03b1 \u03cc\u03c4\u03b9 \u03c3\u03b5 \u03ac\u03bb\u03bb\u03b1 \u03c3\u03c5\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03ac \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c6\u03ad \u03ba\u03b1\u03b9 \u03cc\u03c7\u03b9 \u03c3\u03c4\u03b7\u03bd \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7 \u03bf\u03c6\u03b5\u03af\u03bb\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bf\u03b9 \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b5\u03c2 \u03c0\u03c1\u03bf\u03c3\u03c4\u03b1\u03c4\u03b5\u03c5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 (20). \u0391\u03bd \u03b2\u03ad\u03b2\u03b1\u03b9\u03b1 \u03b7 \u03ba\u03b1\u03c4\u03b1\u03bd\u03ac\u03bb\u03c9\u03c3\u03b7 \u03ba\u03b1\u03c6\u03ad \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03ad\u03c3\u03b5\u03b9 \u03ba\u03b1\u03b9 \u03b1\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1 \u03b2\u03ac\u03c1\u03bf\u03c5\u03c2, \u03b8\u03b1 \u03c5\u03c0\u03ac\u03c1\u03be\u03b5\u03b9 \u03b1\u03b8\u03c1\u03bf\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03bf \u03b5\u03c5\u03bd\u03bf\u03ca\u03ba\u03cc\u00a0 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1.<\/p>\n

    \u038c\u03bc\u03c9\u03c2, \u03c0\u03b1\u03c1\u03ac \u03c4\u03bf \u03cc\u03c4\u03b9 \u03c3\u03b5 \u03bc\u03b1\u03ba\u03c1\u03bf\u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03b2\u03ac\u03c3\u03b7 \u03bf \u03ba\u03b1\u03c6\u03ad\u03c2 \u03ad\u03c7\u03b5\u03b9 \u03c0\u03c1\u03bf\u03c3\u03c4\u03b1\u03c4\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03b4\u03c1\u03ac\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7 \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7 2, \u03b7 \u03bf\u03be\u03b5\u03af\u03b1 \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03bf\u03c0\u03bf\u03b9\u03bf\u03c5\u03b4\u03ae\u03c0\u03bf\u03c4\u03b5 \u03b5\u03af\u03b4\u03bf\u03c5\u03c2 \u03ba\u03b1\u03c6\u03ad \u03c3\u03b5 \u03ae\u03b4\u03b7 \u03b4\u03b9\u03b1\u03b2\u03b7\u03c4\u03b9\u03ba\u03ac \u03ac\u03c4\u03bf\u03bc\u03b1 \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03b3\u03bb\u03c5\u03ba\u03cc\u03b6\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03b5\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd \u03c3\u03b5 \u03bc\u03b1\u03ba\u03c1\u03bf\u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03b2\u03ac\u03c3\u03b7 \u03ba\u03ac\u03bd\u03b5\u03b9 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03c4\u03b7\u03bd \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7\u03c2 \u03b4\u03b9\u03b1\u03b2\u03b7\u03c4\u03b9\u03ba\u03ce\u03bd \u03b5\u03c0\u03b9\u03c0\u03bb\u03bf\u03ba\u03ce\u03bd. \u0395\u03bd\u03b4\u03b9\u03b1\u03c6\u03ad\u03c1\u03bf\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf \u03cc\u03c4\u03b9, \u03b1\u03bd \u03bf \u03b4\u03b9\u03b1\u03b2\u03b7\u03c4\u03b9\u03ba\u03cc\u03c2 \u03c0\u03b9\u03b5\u03b9 \u03ba\u03b1\u03c6\u03ad \u03c7\u03c9\u03c1\u03af\u03c2 \u03c4\u03b7\u03bd \u03c4\u03b1\u03c5\u03c4\u03cc\u03c7\u03c1\u03bf\u03bd\u03b7 \u03bb\u03ae\u03c8\u03b7 \u03c5\u03b4\u03b1\u03c4\u03b1\u03bd\u03b8\u03c1\u03b1\u03ba\u03bf\u03cd\u03c7\u03bf\u03c5 \u03b3\u03b5\u03cd\u03bc\u03b1\u03c4\u03bf\u03c2, \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03b3\u03bb\u03c5\u03ba\u03cc\u03b6\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03b9\u03bd\u03c3\u03bf\u03c5\u03bb\u03af\u03bd\u03b7\u03c2 \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03bf\u03c5\u03bd \u03b1\u03bc\u03b5\u03c4\u03ac\u03b2\u03bb\u03b7\u03c4\u03b1 (21).<\/p>\n

    \u0397 \u03b4\u03c5\u03c3\u03bc\u03b5\u03bd\u03ae\u03c2 \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c6\u03ad \u03c3\u03c4\u03bf \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03c3\u03bc\u03cc \u03c4\u03c9\u03bd \u03c5\u03b4\u03b1\u03c4\u03b1\u03bd\u03b8\u03c1\u03ac\u03ba\u03c9\u03bd \u03c3\u03b5 \u03b4\u03b9\u03b1\u03b2\u03b7\u03c4\u03b9\u03ba\u03ac \u03ac\u03c4\u03bf\u03bc\u03b1 \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03b1\u03bc\u03b2\u03bb\u03cd\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03b1\u03bd \u03ba\u03b1\u03c4\u03b1\u03bd\u03b1\u03bb\u03c9\u03b8\u03b5\u03af \u03ba\u03b1\u03c6\u03ad\u03c2 \u03c7\u03c9\u03c1\u03af\u03c2 \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7.\u039c\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03ad\u03b4\u03b5\u03b9\u03be\u03b1\u03bd \u03cc\u03c4\u03b9 \u03b7 \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7 \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03af\u03b1 \u03c3\u03c4\u03b7\u03bd \u03b9\u03bd\u03c3\u03bf\u03c5\u03bb\u03af\u03bd\u03b7 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03c3\u03ba\u03b5\u03bb\u03b5\u03c4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03bc\u03c5\u03c2 \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03b7 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c0\u03c1\u03cc\u03c3\u03bb\u03b7\u03c8\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03b3\u03bb\u03c5\u03ba\u03cc\u03b6\u03b7\u03c2 \u03b1\u03c0\u03cc \u03b1\u03c5\u03c4\u03bf\u03cd\u03c2 \u03bc\u03ad\u03c7\u03c1\u03b9 \u03ba\u03b1\u03b9 50% \u03bc\u03ad\u03c3\u03c9 \u03c4\u03b7\u03c2 \u03b1\u03bd\u03c4\u03b1\u03b3\u03c9\u03bd\u03b9\u03c3\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c4\u03b7\u03c2 \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7\u03c2 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03b5\u03af\u03c2 \u03b1\u03b4\u03b5\u03bd\u03bf\u03c3\u03af\u03bd\u03b7\u03c2 (22).\u039c\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c3\u03b5 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03bf\u03c5\u03c2 \u03b4\u03b5\u03af\u03c7\u03bd\u03bf\u03c5\u03bd \u03cc\u03c4\u03b9 \u03b7 \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7 \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03af\u03b1 \u03c3\u03c4\u03b7\u03bd \u03b9\u03bd\u03c3\u03bf\u03c5\u03bb\u03af\u03bd\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b1\u03bd\u03bf\u03c7\u03ae \u03c3\u03c4\u03b7 \u03b3\u03bb\u03c5\u03ba\u03cc\u03b6\u03b7\u03c2 \u03ba\u03b1\u03c4\u03ac \u03ba\u03cd\u03c1\u03b9\u03bf \u03bb\u03cc\u03b3\u03bf \u03bc\u03ad\u03c3\u03c9 \u03c4\u03b7\u03c2 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd \u03b5\u03c0\u03b9\u03c0\u03ad\u03b4\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03b4\u03c1\u03ac\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03b5\u03c0\u03b9\u03bd\u03b5\u03c6\u03c1\u03af\u03bd\u03b7\u03c2.<\/p>\n

    \u0386\u03bb\u03bb\u03b1 \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1 \u03c0\u03bf\u03c5 \u03b1\u03c0\u03bf\u03b4\u03b5\u03b9\u03ba\u03bd\u03cd\u03bf\u03c5\u03bd \u03ad\u03bc\u03bc\u03b5\u03c3\u03b1 \u03cc\u03c4\u03b9 \u03bf \u03c0\u03b1\u03c1\u03b1\u03c0\u03ac\u03bd\u03c9 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c5\u03c0\u03b5\u03cd\u03b8\u03c5\u03bd\u03bf\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03c0\u03c1\u03cc\u03ba\u03bb\u03b7\u03c3\u03b7 \u03b9\u03bd\u03c3\u03bf\u03c5\u03bb\u03b9\u03bd\u03bf\u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03b1\u03c3\u03b7\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9:<\/p>\n

      \n
    • \u0397 \u03c0\u03c1\u03cc\u03c3\u03bb\u03b7\u03c8\u03b7 \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7\u03c2 \u03b1\u03c0\u03cc \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03bf\u03c5\u03c2 \u03bc\u03b5 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03b3\u03bc\u03ad\u03bd\u03b7 \u03ad\u03ba\u03ba\u03c1\u03b9\u03c3\u03b7 \u03b5\u03c0\u03b9\u03bd\u03b5\u03c6\u03c1\u03af\u03bd\u03b7\u03c2 \u03b4\u03b5\u03bd \u03ad\u03c7\u03b5\u03b9 \u03ba\u03b1\u03bc\u03af\u03b1 \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c3\u03c4\u03b9\u03c2 \u03c3\u03c5\u03b3\u03ba\u03b5\u03bd\u03c4\u03c1\u03ce\u03c3\u03b5\u03b9\u03c2 \u03b3\u03bb\u03c5\u03ba\u03cc\u03b6\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03b9\u03bd\u03c3\u03bf\u03c5\u03bb\u03af\u03bd\u03b7\u03c2 (22).<\/li>\n
    • \u0397 \u03c4\u03b1\u03c5\u03c4\u03cc\u03c7\u03c1\u03bf\u03bd\u03b7 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03c0\u03c1\u03b1\u03bd\u03bf\u03bb\u03cc\u03bb\u03b7\u03c2, \u03b5\u03bd\u03cc\u03c2 \u03bc\u03b7 \u03b5\u03b9\u03b4\u03b9\u03ba\u03bf\u03cd \u03b2-\u03b1\u03b4\u03c1\u03b5\u03bd\u03b5\u03c1\u03b3\u03b9\u03ba\u03bf\u03cd \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03b1, \u03b1\u03c0\u03ad\u03c4\u03c1\u03b5\u03c8\u03b5 \u03c4\u03b7\u03bd \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7 \u03c5\u03c0\u03b5\u03c1\u03b9\u03bd\u03c3\u03bf\u03c5\u03bb\u03b9\u03bd\u03b1\u03b9\u03bc\u03af\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03b9\u03bd\u03c3\u03bf\u03c5\u03bb\u03b9\u03bd\u03bf\u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03b1\u03c3\u03b7\u03c2 (23).<\/li>\n<\/ul>\n

      \u039c\u03b5\u03bb\u03ad\u03c4\u03b7 \u03c3\u03b5 \u03c5\u03b3\u03b9\u03b5\u03af\u03c2 \u03b5\u03b8\u03b5\u03bb\u03bf\u03bd\u03c4\u03ad\u03c2 \u03ad\u03b4\u03b5\u03b9\u03be\u03b5 \u03cc\u03c4\u03b9 \u03b7 \u03b4\u03c5\u03c3\u03bc\u03b5\u03bd\u03ae\u03c2 \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7\u03c2 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03af\u03b1 \u03c3\u03c4\u03b7\u03bd \u03b9\u03bd\u03c3\u03bf\u03c5\u03bb\u03af\u03bd\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b1\u03c1\u03cc\u03bc\u03bf\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b1 \u03b4\u03cd\u03bf \u03c6\u03cd\u03bb\u03b1, \u03b5\u03af\u03bd\u03b1\u03b9 \u03b4\u03bf\u03c3\u03bf\u03b5\u03be\u03b1\u03c1\u03c4\u03ce\u03bc\u03b5\u03bd\u03b7 \u03ba\u03b1\u03b9 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b1\u03ba\u03cc\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u03bb\u03ae\u03c8\u03b7 \u03c0\u03bf\u03bb\u03cd \u03bc\u03b9\u03ba\u03c1\u03ce\u03bd \u03b4\u03cc\u03c3\u03b5\u03c9\u03bd (1 mg\/\u03ba\u03bb \u03a3\u0392) (24).<\/p>\n

      \u038c\u03c3\u03bf\u03bd \u03b1\u03c6\u03bf\u03c1\u03ac \u03c4\u03b7\u03bd \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c6\u03ad \u03c3\u03c4\u03b7\u03bd \u03ad\u03ba\u03ba\u03c1\u03b9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b9\u03bd\u03c3\u03bf\u03c5\u03bb\u03af\u03bd\u03b7\u03c2, \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03c3\u03b5 \u03bb\u03b5\u03c0\u03c4\u03cc\u03c3\u03c9\u03bc\u03b1 \u03b1\u03bb\u03bb\u03ac \u03cc\u03c7\u03b9 \u03c3\u03b5 \u03c0\u03b1\u03c7\u03cd\u03c3\u03b1\u03c1\u03ba\u03b1 \u03ac\u03c4\u03bf\u03bc\u03b1.\u0397 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03ad\u03ba\u03ba\u03c1\u03b9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b9\u03bd\u03c3\u03bf\u03c5\u03bb\u03af\u03bd\u03b7\u03c2 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03bc\u03cc\u03bd\u03bf \u03bc\u03b5\u03c4\u03ac \u03c6\u03cc\u03c1\u03c4\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03b3\u03bb\u03c5\u03ba\u03cc\u03b6\u03b7 \u03ba\u03b1\u03b9 \u03cc\u03c7\u03b9 \u03c3\u03b5 \u03c6\u03ac\u03c3\u03b7 \u03bd\u03b7\u03c3\u03c4\u03b5\u03af\u03b1\u03c2 (25).<\/p>\n

      \u03a3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b1\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac, \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bc\u03b5 \u03bd\u03b1 \u03c0\u03bf\u03cd\u03bc\u03b5 \u03cc\u03c4\u03b9 \u03b7 \u03c3\u03c5\u03bd\u03ae\u03b8\u03b7\u03c2 \u03ba\u03b1\u03c4\u03b1\u03bd\u03ac\u03bb\u03c9\u03c3\u03b7 \u03ba\u03b1\u03c6\u03ad \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03c4\u03b7\u03bd \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7\u03c2 \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7.\u03a3\u03c4\u03bf\u03c5\u03c2 \u03ae\u03b4\u03b7 \u03b4\u03b9\u03b1\u03b2\u03b7\u03c4\u03b9\u03ba\u03bf\u03cd\u03c2, \u03b7 \u03ba\u03b1\u03c4\u03b1\u03bd\u03ac\u03bb\u03c9\u03c3\u03b7 \u03ba\u03b1\u03c6\u03ad \u03c7\u03c9\u03c1\u03af\u03c2 \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7 \u03b4\u03b5\u03bd \u03ad\u03c7\u03b5\u03b9 \u03b5\u03c0\u03b9\u03b2\u03bb\u03b1\u03b2\u03b5\u03af\u03c2 \u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2.\u0391\u03bd \u03cc\u03bc\u03c9\u03c2 \u03c0\u03c1\u03bf\u03c4\u03b9\u03bc\u03bf\u03cd\u03bd \u03ba\u03b1\u03c6\u03ad \u03bc\u03b5 \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7, \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03b1\u03bb\u03cc \u03bd\u03b1 \u03c4\u03bf\u03bd \u03ba\u03b1\u03c4\u03b1\u03bd\u03b1\u03bb\u03ce\u03bd\u03bf\u03c5\u03bd \u03bc\u03b1\u03ba\u03c1\u03b9\u03ac \u03b1\u03c0\u03cc \u03c5\u03b4\u03b1\u03c4\u03b1\u03bd\u03b8\u03c1\u03b1\u03ba\u03bf\u03cd\u03c7\u03bf \u03b3\u03b5\u03cd\u03bc\u03b1.<\/p>\n

      4. \u0397 \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c6\u03ad \u03c3\u03c4\u03b1 \u03bb\u03b9\u03c0\u03af\u03b4\u03b9\u03b1 \u03c4\u03bf\u03c5 \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2<\/b><\/h4>\n

      \u039f \u03ba\u03b1\u03c6\u03ad\u03c2 \u03c0\u03b5\u03c1\u03b9\u03ad\u03c7\u03b5\u03b9 \u03c7\u03b7\u03bc\u03b9\u03ba\u03ad\u03c2 \u03b5\u03bd\u03ce\u03c3\u03b5\u03b9\u03c2 \u03bc\u03b5 \u03b1\u03c5\u03be\u03b7\u03c4\u03b9\u03ba\u03ae \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c3\u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2.\u03a4\u03b1 \u03c7\u03b7\u03bc\u03b9\u03ba\u03ac \u03b1\u03c5\u03c4\u03ac \u03bc\u03cc\u03c1\u03b9\u03b1 \u03b1\u03bd\u03ae\u03ba\u03bf\u03c5\u03bd \u03c3\u03c4\u03b1 \u03b4\u03b9\u03c4\u03b5\u03c1\u03c0\u03ad\u03bd\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03ba\u03b1\u03c6\u03b5\u03c3\u03c4\u03cc\u03bb\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03ba\u03b1\u03c7\u03b5\u03cc\u03bb\u03b7 (26).<\/p>\n

      \u0395\u03af\u03bd\u03b1\u03b9 \u03b5\u03bd\u03b4\u03b9\u03b1\u03c6\u03ad\u03c1\u03bf\u03bd \u03c4\u03bf \u03cc\u03c4\u03b9 \u03b7 \u03c0\u03c5\u03ba\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03c9\u03bd \u03b5\u03bd\u03ce\u03c3\u03b5\u03c9\u03bd \u03b1\u03c5\u03c4\u03ce\u03bd \u03b5\u03be\u03b1\u03c1\u03c4\u03ac\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf \u03c0\u03c9\u03c2 \u03c0\u03b1\u03c1\u03b1\u03c3\u03ba\u03b5\u03c5\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bf \u03ba\u03b1\u03c6\u03ad\u03c2.\u039f \u03b2\u03c1\u03b1\u03c3\u03c4\u03cc\u03c2 \u03ba\u03b1\u03c6\u03ad\u03c2, \u03c0\u03bf\u03c5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03bf \u0395\u03bb\u03bb\u03b7\u03bd\u03b9\u03ba\u03cc\u03c2, \u03ad\u03c7\u03b5\u03b9 \u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03c3\u03c5\u03b3\u03ba\u03b5\u03bd\u03c4\u03c1\u03ce\u03c3\u03b5\u03b9\u03c2, \u03b4\u03b9\u03cc\u03c4\u03b9 \u03c4\u03b1 \u03b4\u03b9\u03c4\u03b5\u03c1\u03c0\u03ad\u03bd\u03b9\u03b1 \u03c0\u03bf\u03c5 \u03b2\u03c1\u03af\u03c3\u03ba\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03ba\u03cc\u03ba\u03ba\u03bf\u03c5\u03c2 \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c6\u03ad \u03b5\u03ba\u03c7\u03c5\u03bb\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf \u03b1\u03c6\u03ad\u03c8\u03b7\u03bc\u03b1 \u03bb\u03cc\u03b3\u03c9 \u03c4\u03b7\u03c2 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b5\u03c4\u03b1\u03bc\u03ad\u03bd\u03b7\u03c2 \u03b5\u03c0\u03b1\u03c6\u03ae\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03bc\u03b5 \u03c4\u03bf \u03b6\u03b5\u03c3\u03c4\u03cc \u03bd\u03b5\u03c1\u03cc.\u0391\u03bd\u03c4\u03af\u03b8\u03b5\u03c4\u03b1, \u03bf \u03ba\u03b1\u03c6\u03ad\u03c2 \u03c6\u03af\u03bb\u03c4\u03c1\u03bf\u03c5 \u03c0\u03b5\u03c1\u03b9\u03ad\u03c7\u03b5\u03b9 \u03c0\u03bf\u03bb\u03cd \u03bc\u03b9\u03ba\u03c1\u03cc\u03c4\u03b5\u03c1\u03b1 \u03c0\u03bf\u03c3\u03ac \u03ba\u03b1\u03c6\u03b5\u03c3\u03c4\u03cc\u03bb\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03ba\u03b1\u03c7\u03b5\u03cc\u03bb\u03b7\u03c2 \u03bb\u03cc\u03b3\u03c9 \u03c4\u03b7\u03c2 \u03bc\u03b9\u03ba\u03c1\u03cc\u03c4\u03b5\u03c1\u03b7\u03c2 \u03b5\u03c0\u03b1\u03c6\u03ae\u03c2 \u03bc\u03b5 \u03c4\u03bf \u03b6\u03b5\u03c3\u03c4\u03cc \u03bd\u03b5\u03c1\u03cc \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03ba\u03b1\u03c4\u03b1\u03ba\u03c1\u03ac\u03c4\u03b7\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd \u03b4\u03b9\u03c4\u03b5\u03c1\u03c0\u03b5\u03bd\u03af\u03c9\u03bd \u03b1\u03c0\u03cc \u03c4\u03bf \u03b4\u03b9\u03b7\u03b8\u03b7\u03c4\u03b9\u03ba\u03cc \u03c7\u03b1\u03c1\u03c4\u03af.<\/p>\n

      \u0397 \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c6\u03ad \u03c3\u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03c9\u03bd \u03bb\u03b9\u03c0\u03b9\u03b4\u03af\u03c9\u03bd \u03c4\u03bf\u03c5 \u03bf\u03c1\u03bf\u03cd \u03bc\u03b5\u03bb\u03b5\u03c4\u03ae\u03b8\u03b7\u03ba\u03b5 \u03c3\u03b5 107 \u03b5\u03bd\u03ae\u03bb\u03b9\u03ba\u03b5\u03c2 \u03bc\u03b5 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03ae\u03b8\u03b7\u03ba\u03b1\u03bd \u03b5\u03c0\u03af 12 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2. \u039f \u03ba\u03b1\u03c6\u03ad\u03c2 \u03c0\u03b1\u03c1\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03b6\u03cc\u03c4\u03b1\u03bd \u03bc\u03b5 2 \u03c3\u03c5\u03bd\u03ae\u03b8\u03b5\u03b9\u03c2 \u03bc\u03b5\u03b8\u03cc\u03b4\u03bf\u03c5\u03c2, \u03b4\u03b9\u03ae\u03b8\u03b7\u03c3\u03b7 \u03b1\u03c0\u03cc \u03c6\u03af\u03bb\u03c4\u03c1\u03bf \u03ba\u03b1\u03b9 \u03b2\u03c1\u03ac\u03c3\u03b9\u03bc\u03bf. \u039f\u03b9 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03ad\u03c7\u03bf\u03bd\u03c4\u03b5\u03c2 \u03c7\u03c9\u03c1\u03af\u03c3\u03c4\u03b7\u03ba\u03b1\u03bd \u03c3\u03b5 3 \u03bf\u03bc\u03ac\u03b4\u03b5\u03c2: \u0397 \u03c0\u03c1\u03ce\u03c4\u03b7\u00a0 \u03bf\u03bc\u03ac\u03b4\u03b1 \u03ba\u03b1\u03c4\u03b1\u03bd\u03ac\u03bb\u03c9\u03bd\u03b5 4-6 \u03c6\u03bb\u03b9\u03c4\u03b6\u03ac\u03bd\u03b9\u03b1\/\u03b7\u03bc. \u03b2\u03c1\u03b1\u03c3\u03bc\u03ad\u03bd\u03bf \u03ba\u03b1\u03c6\u03ad, \u03b7 \u03b4\u03b5\u03cd\u03c4\u03b5\u03c1\u03b7 4-6 \u03c6\u03bb\u03b9\u03c4\u03b6\u03ac\u03bd\u03b9\u03b1\/\u03b7\u03bc.\u03ba\u03b1\u03c6\u03ad \u03c6\u03af\u03bb\u03c4\u03c1\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03b7 \u03c4\u03c1\u03af\u03c4\u03b7 \u03bf\u03bc\u03ac\u03b4\u03b1 \u03b4\u03b5\u03bd \u03ad\u03c0\u03b9\u03bd\u03b5 \u03ba\u03b1\u03b8\u03cc\u03bb\u03bf\u03c5 \u03ba\u03b1\u03c6\u03ad.<\/p>\n

      \u03a3\u03c4\u03b1 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03c0\u03bf\u03c5 \u03ba\u03b1\u03c4\u03b1\u03bd\u03ac\u03bb\u03c9\u03bd\u03b1\u03bd \u03b2\u03c1\u03b1\u03c3\u03c4\u03cc \u03ba\u03b1\u03c6\u03ad \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03ae\u03b8\u03b7\u03ba\u03b5 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c3\u03c4\u03b7\u03bd \u03bf\u03bb\u03b9\u03ba\u03ae \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7 \u03ba\u03b1\u03b9 \u03bc\u03b9\u03ba\u03c1\u03ae \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 LDL. \u0391\u03bd\u03c4\u03af\u03b8\u03b5\u03c4\u03b1, \u03b4\u03b5\u03bd \u03c5\u03c0\u03ae\u03c1\u03be\u03b5 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03ac \u03c3\u03c4\u03b1\u00a0 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03b7\u03c2 \u03bf\u03bb\u03b9\u03ba\u03ae\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 LDL \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03c4\u03b7\u03c2 \u03bf\u03bc\u03ac\u03b4\u03b1\u03c2 \u03c0\u03bf\u03c5 \u03ad\u03c0\u03b9\u03bd\u03b5 \u03ba\u03b1\u03c6\u03ad \u03c6\u03af\u03bb\u03c4\u03c1\u03bf\u03c5\u00a0 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03bf\u03bc\u03ac\u03b4\u03b1 \u03c0\u03bf\u03c5 \u03b4\u03b5\u03bd \u03ad\u03c0\u03b9\u03bd\u03b5 \u03ba\u03b1\u03b8\u03cc\u03bb\u03bf\u03c5 \u03ba\u03b1\u03c6\u03ad (27).<\/p>\n

      \u03a4\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03b1\u03c5\u03c4\u03ac \u03c3\u03c5\u03bc\u03c6\u03c9\u03bd\u03bf\u03cd\u03bd \u03bc\u03b5 \u03bc\u03b9\u03b1 \u03bc\u03b5\u03c4\u03b1-\u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 14 RCTs \u03c3\u03c4\u03b9\u03c2 \u03bf\u03c0\u03bf\u03af\u03b5\u03c2 \u03b4\u03b5\u03af\u03c7\u03c4\u03b7\u03ba\u03b5 \u03cc\u03c4\u03b9 \u03b7 \u03ba\u03b1\u03c4\u03b1\u03bd\u03ac\u03bb\u03c9\u03c3\u03b7 \u03b2\u03c1\u03b1\u03c3\u03c4\u03bf\u03cd \u03ba\u03b1\u03c6\u03ad \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af \u03b4\u03bf\u03c3\u03bf\u03b5\u03be\u03b1\u03c1\u03c4\u03ce\u03bc\u03b5\u03bd\u03b7 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b5\u03c0\u03b9\u03c0\u03ad\u03b4\u03c9\u03bd \u03c4\u03b7\u03c2 LDL, \u03b5\u03bd\u03ce \u03b7 \u03ba\u03b1\u03c4\u03b1\u03bd\u03ac\u03bb\u03c9\u03c3\u03b7 \u03ba\u03b1\u03c6\u03ad \u03c6\u03af\u03bb\u03c4\u03c1\u03bf\u03c5 \u03b5\u03c0\u03b9\u03c6\u03ad\u03c1\u03b5\u03b9 \u03c0\u03bf\u03bb\u03cd \u03bc\u03b9\u03ba\u03c1\u03ae \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ae \u03c3\u03c4\u03b7 \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7 \u03c4\u03bf\u03c5 \u03bf\u03c1\u03bf\u03cd (28). \u039c\u03af\u03b1 \u03b1\u03ba\u03cc\u03bc\u03b1 \u03c0\u03c1\u03cc\u03c3\u03c6\u03b1\u03c4\u03b7 \u03bc\u03b5\u03c4\u03b1-\u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 (29) \u03c0\u03bf\u03c5 \u03ad\u03b3\u03b9\u03bd\u03b5 \u03c3\u03b5 12 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03b1\u03c0\u03cc \u03b4\u03c5\u03c4\u03b9\u03ba\u03bf\u03cd \u03c4\u03cd\u03c0\u03bf\u03c5 \u03ba\u03bf\u03b9\u03bd\u03c9\u03bd\u03af\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03ad\u03bb\u03b1\u03b2\u03b5 1017 \u03ac\u03c4\u03bf\u03bc\u03b1, \u03ad\u03b4\u03b5\u03b9\u03be\u03b5 \u03cc\u03c4\u03b9 \u03b7 \u03ba\u03b1\u03c4\u03b1\u03bd\u03ac\u03bb\u03c9\u03c3\u03b7 \u03ac\u03c6\u03b9\u03bb\u03c4\u03c1\u03bf\u03c5 \u03ba\u03b1\u03c6\u03ad \u03b5\u03af\u03c7\u03b5 \u03c4\u03b1 \u03b5\u03be\u03ae\u03c2 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1: \u03bc\u03ad\u03c3\u03b7 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bf\u03bb\u03b9\u03ba\u03ae\u03c2 \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2 \u03ba\u03b1\u03c4\u03ac 8.1 mg\/dl, \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 LDL \u03ba\u03b1\u03c4\u03ac 5.4 mg\/dl \u03ba\u03b1\u03b9 \u03c4\u03c9\u03bd \u03c4\u03c1\u03b9\u03b3\u03bb\u03c5\u03ba\u03b5\u03c1\u03b9\u03b4\u03af\u03c9\u03bd \u03ba\u03b1\u03c4\u03ac 12.6 mg\/dl \u03ba\u03b1\u03b9 \u03bc\u03ac\u03bb\u03b9\u03c3\u03c4\u03b1, \u03bf\u03b9 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b5\u03c2 \u03b1\u03c5\u03be\u03ae\u03c3\u03b5\u03b9\u03c2 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03ae\u03b8\u03b7\u03ba\u03b1\u03bd \u03c3\u03b5 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03bc\u03b5 \u03b4\u03c5\u03c3\u03bb\u03b9\u03c0\u03b9\u03b4\u03b1\u03b9\u03bc\u03af\u03b1.<\/p>\n

      \u039c\u03b5\u03bb\u03ad\u03c4\u03b7 \u03c3\u03b5 \u03bc\u03b9\u03b1 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b7 \u03bf\u03bc\u03ac\u03b4\u03b1 \u03b1\u03c0\u03cc 132.000 \u03ac\u03bd\u03b4\u03c1\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03b3\u03c5\u03bd\u03b1\u03af\u03ba\u03b5\u03c2 (\u2018Health Professionals Follow-up Study\u2019 \u03ba\u03b1\u03b9 \u2018Nurses\u2019 Health Study\u2019), \u03c7\u03c9\u03c1\u03af\u03c2 \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc \u03c3\u03c4\u03b5\u03c6\u03b1\u03bd\u03b9\u03b1\u03af\u03b1\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5 \u03ae \u03ba\u03b1\u03ba\u03bf\u03ae\u03b8\u03b5\u03b9\u03b1\u03c2, \u03b4\u03b5\u00a0 \u03b2\u03c1\u03ad\u03b8\u03b7\u03ba\u03b5 \u03ba\u03b1\u03bc\u03af\u03b1 \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c6\u03b9\u03bb\u03c4\u03c1\u03b1\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03c5 \u03ba\u03b1\u03c6\u03ad \u03c3\u03c4\u03b7\u03bd \u03bf\u03bb\u03b9\u03ba\u03ae, \u03c3\u03c4\u03b7\u03bd LDL \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd HDL \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7 (30).<\/p>\n

      \u039f \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc\u03c4\u03b5\u03c1\u03bf\u03c2 \u03c5\u03c0\u03b5\u03c1\u03bb\u03b9\u03c0\u03b9\u03b4\u03b1\u03b9\u03bc\u03b9\u03ba\u03cc\u03c2 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c6\u03ad \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03ba\u03b1\u03c6\u03b5\u03c3\u03c4\u03cc\u03bb\u03b7. \u0397 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03c4\u03b5\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c9\u03c2 \u03c5\u03c0\u03b5\u03cd\u03b8\u03c5\u03bd\u03bf\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b4\u03c1\u03ac\u03c3\u03b7 \u03b1\u03c5\u03c4\u03ae \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf \u03b5\u03be\u03ae\u03c2 (31):<\/p>\n

      \u0397 \u03ba\u03b1\u03c6\u03b5\u03c3\u03c4\u03cc\u03bb\u03b7 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03c4\u03bf\u03c5\u03c2 \u03bf\u03c1\u03bc\u03bf\u03bd\u03b9\u03ba\u03bf\u03cd\u03c2 \u03c0\u03c5\u03c1\u03b7\u03bd\u03b9\u03ba\u03bf\u03cd\u03c2 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03b5\u03af\u03c2 PXR (pregnane X receptor) \u03ba\u03b1\u03b9 \u03c4\u03bf\u03c5\u03c2 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03b5\u03af\u03c2 FXR (farnesoid X receptor) \u03c4\u03bf\u03c5 \u03bb\u03b5\u03c0\u03c4\u03bf\u03cd \u03b5\u03bd\u03c4\u03ad\u03c1\u03bf\u03c5.\u03a3\u03c4\u03b7 \u03c3\u03c5\u03bd\u03ad\u03c7\u03b5\u03b9\u03b1, \u03bf\u03b9 PXR \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd \u03c4\u03b7\u03bd \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03c9\u03bd Cyp27A1 \u03ba\u03b1\u03b9 ABCA1, \u03b1\u03c5\u03be\u03ac\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7\u03bd \u03b5\u03ba\u03c1\u03bf\u03ae \u03c4\u03b7\u03c2 \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2 \u03c0\u03c1\u03bf\u03c2 \u03c4\u03bf \u03ae\u03c0\u03b1\u03c1.\u039f\u03b9 FXR \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd \u03ad\u03bd\u03b1\u03bd \u03b5\u03bd\u03c4\u03b5\u03c1\u03b9\u03ba\u03cc \u03bc\u03b5\u03c4\u03b1\u03c6\u03bf\u03c1\u03ad\u03b1 \u03c4\u03c9\u03bd \u03c7\u03bf\u03bb\u03b9\u03ba\u03ce\u03bd \u03bf\u03be\u03ad\u03c9\u03bd, \u03c4\u03b7\u03bd \u0399\u0392\u0391\u0392\u03a1 (intestinal bile acid binding protein), \u03b1\u03c5\u03be\u03ac\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7 \u03bc\u03b5\u03c4\u03b1\u03c6\u03bf\u03c1\u03ac \u03c4\u03c9\u03bd \u03c7\u03bf\u03bb\u03b9\u03ba\u03ce\u03bd \u03bf\u03be\u03ad\u03c9\u03bd \u03c3\u03c4\u03b7\u03bd \u03c0\u03c5\u03bb\u03b1\u03af\u03b1 \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03af\u03b1.\u03a4\u03cc\u03c3\u03bf \u03bf\u03b9 PXR \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03bf\u03b9 FXR \u03b5\u03c0\u03ac\u03b3\u03bf\u03c5\u03bd \u03c4\u03bf\u03bd \u03b1\u03c5\u03be\u03b7\u03c4\u03b9\u03ba\u03cc \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1 \u03c4\u03c9\u03bd \u03b9\u03bd\u03bf\u03b2\u03bb\u03b1\u03c3\u03c4\u03ce\u03bd 15 (FGF15), \u03b7 \u03b4\u03c1\u03ac\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03bf\u03c0\u03bf\u03af\u03bf\u03c5 \u03b1\u03bd\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03b5\u03b9 \u03c4\u03b7 \u03c3\u03cd\u03bd\u03b8\u03b5\u03c3\u03b7 \u03c7\u03bf\u03bb\u03b9\u03ba\u03ce\u03bd \u03bf\u03be\u03ad\u03c9\u03bd \u03c3\u03c4\u03bf \u03ae\u03c0\u03b1\u03c1. \u039f\u03b9 FXR \u03c3\u03c4\u03bf \u03ae\u03c0\u03b1\u03c1 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03c9\u03bd\u00a0 Cyp7A1, Cyp8B1 \u03ba\u03b1\u03b9 NTCP (Na+<\/sup>-taurocholatecotransportingpolypeptide), \u03bc\u03b5\u03b9\u03ce\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7 \u03c3\u03cd\u03bd\u03b8\u03b5\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c7\u03bf\u03bb\u03b9\u03ba\u03ce\u03bd \u03bf\u03be\u03ad\u03c9\u03bd \u03ba\u03b1\u03b9 \u03b5\u03c0\u03bf\u03bc\u03ad\u03bd\u03c9\u03c2 \u03b5\u03c0\u03ad\u03c1\u03c7\u03b5\u03c4\u03b1\u03b9 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c3\u03c4\u03b9\u03c2 \u03c3\u03c5\u03b3\u03ba\u03b5\u03bd\u03c4\u03c1\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2.<\/p>\n

      \u0395\u03bd \u03ba\u03b1\u03c4\u03b1\u03ba\u03bb\u03b5\u03af\u03b4\u03b9, \u03b7 \u03ba\u03b1\u03c6\u03b5\u03c3\u03c4\u03cc\u03bb\u03b7 \u03b4\u03c1\u03b1 \u03c9\u03c2 \u03b1\u03b3\u03c9\u03bd\u03b9\u03c3\u03c4\u03b9\u03ba\u03cc \u03bc\u03cc\u03c1\u03b9\u03bf \u03c3\u03cd\u03bd\u03b4\u03b5\u03c3\u03b7\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03c5\u03c2 FXR \u03ba\u03b1\u03b9 PXR \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03b1\u03c5\u03c4\u03cc \u03bf\u03c6\u03b5\u03af\u03bb\u03b5\u03c4\u03b1\u03b9 \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b7 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b5\u03c0\u03b9\u03c0\u03ad\u03b4\u03c9\u03bd \u03c4\u03b7\u03c2 \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2.<\/p>\n

      5.1. \u0397 \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c6\u03ad \u03c3\u03b5 \u03b3\u03c5\u03bd\u03b1\u03af\u03ba\u03b5\u03c2 \u03b1\u03bd\u03b1\u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03b9\u03ba\u03ae\u03c2 \u03b7\u03bb\u03b9\u03ba\u03af\u03b1\u03c2<\/b><\/h5>\n

      \u03a5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03c0\u03bf\u03bb\u03bb\u03ad\u03c2 \u03b2\u03b9\u03b2\u03bb\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03b9\u03ba\u03ad\u03c2 \u03b1\u03bd\u03b1\u03c6\u03bf\u03c1\u03ad\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b9\u03c2 \u03c0\u03b1\u03b8\u03bf\u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c4\u03b7\u03c2 \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03c9\u03bd \u03ac\u03bb\u03bb\u03c9\u03bd \u03c3\u03c5\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03ce\u03bd \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c6\u03ad\u00a0 \u03c3\u03c4\u03b9\u03c2 \u03b3\u03b5\u03bd\u03bd\u03b7\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bf\u03c1\u03bc\u03cc\u03bd\u03b5\u03c2, \u03c3\u03c4\u03b7\u03bd \u03ad\u03bc\u03bc\u03b7\u03bd\u03bf \u03c1\u03cd\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03c9\u03bf\u03c1\u03c1\u03b7\u03ba\u03c4\u03b9\u03ba\u03ae \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03bd\u03b5\u03b1\u03c1\u03ce\u03bd \u03b3\u03c5\u03bd\u03b1\u03b9\u03ba\u03ce\u03bd.<\/p>\n

      \u0388\u03c7\u03b5\u03b9 \u03b2\u03c1\u03b5\u03b8\u03b5\u03af \u03c3\u03b5 \u03c0\u03b5\u03b9\u03c1\u03b1\u03bc\u03b1\u03c4\u03cc\u03b6\u03c9\u03b1 \u03cc\u03c4\u03b9 \u03b7 \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b1\u03bd\u03b1\u03c3\u03c4\u03b5\u03af\u03bb\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c9\u03c1\u03af\u03bc\u03b1\u03bd\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c9\u03b1\u03c1\u03af\u03c9\u03bd \u03ae \u03bd\u03b1 \u03b5\u03bd\u03b9\u03c3\u03c7\u03cd\u03c3\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03c3\u03c4\u03b5\u03c1\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03bf\u03c1\u03bc\u03bf\u03bd\u03ce\u03bd \u03bc\u03ad\u03c3\u03c9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2 \u03c4\u03b7\u03c2 \u03c6\u03c9\u03c3\u03c6\u03bf\u03b4\u03b9\u03b5\u03c3\u03c4\u03b5\u03c1\u03ac\u03c3\u03b7\u03c2 \u03ae \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9 \u03c3\u03c4\u03bf \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03c3\u03bc\u03cc \u03c4\u03c9\u03bd \u03bf\u03b9\u03c3\u03c4\u03c1\u03bf\u03b3\u03cc\u03bd\u03c9\u03bd \u03bc\u03ad\u03c3\u03c9 \u03c4\u03b7\u03c2 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2 \u03c4\u03b7\u03c2 \u03b1\u03c1\u03c9\u03bc\u03b1\u03c4\u03ac\u03c3\u03b7\u03c2, \u03c4\u03bf \u03ad\u03bd\u03b6\u03c5\u03bc\u03bf \u03ba\u03bb\u03b5\u03b9\u03b4\u03af \u03c5\u03c0\u03b5\u03cd\u03b8\u03c5\u03bd\u03bf \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03bc\u03b5\u03c4\u03b1\u03c4\u03c1\u03bf\u03c0\u03ae \u03c4\u03c9\u03bd \u03b1\u03bd\u03b4\u03c1\u03bf\u03b3\u03cc\u03bd\u03c9\u03bd \u03c3\u03b5 \u03bf\u03b9\u03c3\u03c4\u03c1\u03bf\u03b3\u03cc\u03bd\u03b1 (32, 33).<\/p>\n

      \u039f\u03b9 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03cc\u03bc\u03c9\u03c2 \u03c3\u03b5 \u03b3\u03c5\u03bd\u03b1\u03af\u03ba\u03b5\u03c2 \u03b4\u03b5 \u03c3\u03c5\u03bc\u03c6\u03c9\u03bd\u03bf\u03cd\u03bd \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03c4\u03bf\u03c5\u03c2.\u0388\u03c7\u03bf\u03c5\u03bd \u03b4\u03b5\u03af\u03be\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03b7 \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03b8\u03b5\u03c4\u03b9\u03ba\u03ae, \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae \u03ae \u03ba\u03b1\u03bc\u03b9\u03ac \u03c3\u03c5\u03c3\u03c7\u03ad\u03c4\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03bf\u03b9\u03c3\u03c4\u03c1\u03b1\u03b4\u03b9\u03cc\u03bb\u03b7 (34, 35, 36).\u03a4\u03bf \u03c6\u03b1\u03b9\u03bd\u03cc\u03bc\u03b5\u03bd\u03bf \u03b1\u03c5\u03c4\u03cc \u03bf\u03c6\u03b5\u03af\u03bb\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf \u03cc\u03c4\u03b9 \u03c4\u03cc\u03c3\u03bf \u03b7 \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7 \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03b7 \u03952 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf \u03b7\u03c0\u03b1\u03c4\u03b9\u03ba\u03cc \u03ad\u03bd\u03b6\u03c5\u03bc\u03bf CYP1A2 (Cytochrome P450 1A2). \u039f\u03b9 \u03c0\u03bf\u03bb\u03c5\u03bc\u03bf\u03c1\u03c6\u03b9\u03c3\u03bc\u03bf\u03af \u03c4\u03bf\u03c5 \u03b5\u03bd\u03b6\u03cd\u03bc\u03bf\u03c5 \u03b1\u03c5\u03c4\u03bf\u03cd \u03ad\u03c7\u03bf\u03c5\u03bd \u03c3\u03c5\u03bd\u03b4\u03b5\u03b8\u03b5\u03af \u03bc\u03b5 \u03c4\u03b7 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bb\u03b7\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03ba\u03ac\u03b8\u03b1\u03c1\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b9\u03c2 \u03c3\u03c5\u03b3\u03ba\u03b5\u03bd\u03c4\u03c1\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c4\u03b7\u03c2 \u03952 \u03c3\u03c4\u03bf\u03bd \u03bf\u03c1\u03cc \u03ba\u03b1\u03b9 \u03b1\u03c5\u03c4\u03cc \u03b1\u03ba\u03c1\u03b9\u03b2\u03ce\u03c2 \u03c4\u03c1\u03bf\u03c0\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03c4\u03b7 \u03c3\u03c7\u03ad\u03c3\u03b7 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03c4\u03b7\u03c2 \u03c0\u03c1\u03cc\u03c3\u03bb\u03b7\u03c8\u03b7\u03c2 \u03ba\u03b1\u03c6\u03ad \u03ba\u03b1\u03b9 \u03c4\u03c9\u03bd \u03b5\u03c0\u03b9\u03b2\u03bb\u03b1\u03b2\u03ce\u03bd \u03c4\u03bf\u03c5 \u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03c9\u03bd\u00a0 \u03c3\u03c4\u03b7\u03bd \u03c5\u03b3\u03b5\u03af\u03b1 (37).<\/p>\n

      \u039f \u03c1\u03c5\u03b8\u03bc\u03cc\u03c2 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03c3\u03bc\u03bf\u03cd \u03c4\u03c9\u03bd \u03bf\u03b9\u03c3\u03c4\u03c1\u03bf\u03b3\u03cc\u03bd\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7\u03c2 \u03ad\u03c7\u03b5\u03b9 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b7 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1, \u03c0\u03bb\u03ad\u03bf\u03bd \u03c4\u03c9\u03bd \u03ac\u03bb\u03bb\u03c9\u03bd \u03ba\u03b1\u03b9 \u03bb\u03cc\u03b3\u03c9 \u03c4\u03b7\u03c2 \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7\u03c2 \u03c3\u03c4\u03bf \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03cc \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7\u03c2 \u03bf\u03c1\u03bc\u03bf\u03bd\u03bf-\u03b5\u03be\u03b1\u03c1\u03c4\u03ce\u03bc\u03b5\u03bd\u03c9\u03bd \u03bd\u03b5\u03bf\u03c0\u03bb\u03b1\u03c3\u03bc\u03ac\u03c4\u03c9\u03bd.<\/p>\n

      \u0395\u03ba\u03c4\u03cc\u03c2 \u03cc\u03bc\u03c9\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5\u03c2 \u03b3\u03bf\u03bd\u03b9\u03b4\u03b9\u03b1\u03ba\u03bf\u03cd\u03c2 \u03c0\u03bf\u03bb\u03c5\u03bc\u03bf\u03c1\u03c6\u03b9\u03c3\u03bc\u03bf\u03cd\u03c2, \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03ac \u03c3\u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03bf\u03b9\u03c3\u03c4\u03c1\u03bf\u03b3\u03cc\u03bd\u03c9\u03bd \u03ba\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd \u03b1\u03bd \u03b7 \u03c0\u03c1\u03cc\u03c3\u03bb\u03b7\u03c8\u03b7 \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7\u03c2 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03ad\u03c3\u03c9 \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c6\u03ad \u03ae \u03bc\u03ad\u03c3\u03c9 \u03c4\u03c3\u03b1\u03b3\u03b9\u03bf\u03cd \u03ae \u03ac\u03bb\u03bb\u03c9\u03bd \u03b5\u03bd\u03b5\u03c1\u03b3\u03b5\u03b9\u03b1\u03ba\u03ce\u03bd \u03c0\u03bf\u03c4\u03ce\u03bd. \u03a0\u03c1\u03cc\u03c3\u03c6\u03b1\u03c4\u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03ad\u03b4\u03b5\u03b9\u03be\u03b5 \u03cc\u03c4\u03b9 \u03c3\u03b5 \u03b3\u03c5\u03bd\u03b1\u03af\u03ba\u03b5\u03c2 \u03c4\u03b7\u03c2 \u039a\u03b1\u03c5\u03ba\u03ac\u03c3\u03b9\u03b1\u03c2 \u03c6\u03c5\u03bb\u03ae\u03c2 \u03b7 \u03bc\u03ad\u03c4\u03c1\u03b9\u03b1 \u03ba\u03b1\u03c4\u03b1\u03bd\u03ac\u03bb\u03c9\u03c3\u03b7 \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7\u03c2 \u03bc\u03ad\u03c3\u03c9 \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c6\u03ad \u03b5\u03af\u03c7\u03b5 \u03c3\u03c4\u03b1\u03c4\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03c3\u03c7\u03ad\u03c4\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03bc\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03952 \u03c3\u03c4\u03bf\u03bd \u03bf\u03c1\u03cc, \u03b5\u03bd\u03ce \u03b7 \u03ba\u03b1\u03c4\u03b1\u03bd\u03ac\u03bb\u03c9\u03c3\u03b7 \u03ba\u03b1\u03c6\u03b5\u03ca\u03bd\u03bf\u03cd\u03c7\u03c9\u03bd \u03b1\u03bd\u03b1\u03c8\u03c5\u03ba\u03c4\u03b9\u03ba\u03ce\u03bd\u00a0 \u03ae\/\u03ba\u03b1\u03b9 \u03c0\u03c1\u03ac\u03c3\u03b9\u03bd\u03bf\u03c5 \u03c4\u03c3\u03b1\u03b3\u03b9\u03bf\u03cd \u03c3\u03c5\u03c3\u03c7\u03b5\u03c4\u03af\u03c3\u03c4\u03b7\u03ba\u03b5 \u03bc\u03b5 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b5\u03c2 \u03c3\u03c5\u03b3\u03ba\u03b5\u03bd\u03c4\u03c1\u03ce\u03c3\u03b5\u03b9\u03c2 \u03952 \u03c3\u03b5 \u03b3\u03c5\u03bd\u03b1\u03af\u03ba\u03b5\u03c2 \u03cc\u03bb\u03c9\u03bd \u03c4\u03c9\u03bd \u03c6\u03c5\u03bb\u03ce\u03bd (38).<\/p>\n

      \u0397 \u03bf\u03b9\u03c3\u03c4\u03c1\u03bf\u03b3\u03bf\u03bd\u03b9\u03ba\u03ae \u03b4\u03c1\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03cc\u03bc\u03c9\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03b7\u03c2 SHBG (Sex hormone binding globulin) \u03c4\u03b1 \u03bf\u03c0\u03bf\u03af\u03b1 \u03cc\u03c0\u03c9\u03c2 \u03b4\u03b5\u03af\u03c7\u03b8\u03b7\u03ba\u03b5 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03c0\u03bf\u03c3\u03bf\u03c4\u03b9\u03ba\u03ae \u03c0\u03c1\u03cc\u03c3\u03bb\u03b7\u03c8\u03b7 \u03ba\u03b1\u03c6\u03ad.\u03a3\u03b5 \u03bc\u03af\u03b1 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 (39) \u03b4\u03b5\u03af\u03c7\u03b8\u03b7\u03ba\u03b5 \u03cc\u03c4\u03b9 \u03c4\u03b1 \u03bc\u03ad\u03c3\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 SHBG \u03ae\u03c4\u03b1\u03bd 26,6 nmol \/ l \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03c4\u03c9\u03bd \u03b3\u03c5\u03bd\u03b1\u03b9\u03ba\u03ce\u03bd \u03c0\u03bf\u03c5 \u03ba\u03b1\u03c4\u03b1\u03bd\u03ac\u03bb\u03c9\u03bd\u03b1\u03bd 4 \u03c6\u03bb\u03b9\u03c4\u03b6\u03ac\u03bd\u03b9\u03b1 \/ \u03b7\u03bc\u03ad\u03c1\u03b1 \u03ba\u03b1\u03c6\u03ad \u03bc\u03b5 \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7 \u03ba\u03b1\u03b9 23,0 nmol \/ l \u03c3\u03b5 \u03b1\u03c5\u03c4\u03ad\u03c2 \u03c0\u03bf\u03c5 \u03b4\u03b5\u03bd \u03ad\u03c0\u03b9\u03bd\u03b1\u03bd \u03ba\u03b1\u03b8\u03cc\u03bb\u03bf\u03c5 \u03ba\u03b1\u03c6\u03ad (P \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03c4\u03ac\u03c3\u03b7= 0,01).\u0391\u03be\u03af\u03b6\u03b5\u03b9 \u03bd\u03b1 \u03c3\u03b7\u03bc\u03b5\u03b9\u03c9\u03b8\u03b5\u03af \u03cc\u03c4\u03b9, \u03c0\u03c1\u03cc\u03c3\u03c6\u03b1\u03c4\u03b1 \u03c0\u03b5\u03b9\u03c1\u03ac\u03bc\u03b1\u03c4\u03b1 \u03b4\u03b5\u03af\u03c7\u03bd\u03bf\u03c5\u03bd \u03cc\u03c4\u03b9 \u03b7 SHBG \u03c1\u03c5\u03b8\u03bc\u03af\u03b6\u03b5\u03b9 \u03cc\u03c7\u03b9 \u03bc\u03cc\u03bd\u03bf \u03c4\u03bf \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ce\u03c2 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03cc \u03ba\u03bb\u03ac\u03c3\u03bc\u03b1 \u03c4\u03c9\u03bd \u03bf\u03c1\u03bc\u03bf\u03bd\u03ce\u03bd \u03c4\u03bf\u03c5 \u03c6\u03cd\u03bb\u03bf\u03c5, \u03b1\u03bb\u03bb\u03ac \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b4\u03b5\u03c3\u03bc\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03bf\u03c5\u03c2 \u03b4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03bc\u03b5\u03bc\u03b2\u03c1\u03b1\u03bd\u03b9\u03ba\u03bf\u03cd\u03c2 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03b5\u03af\u03c2 \u03bc\u03b9\u03b1\u03c2 \u03c0\u03bf\u03b9\u03ba\u03b9\u03bb\u03af\u03b1\u03c2 \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd, \u03bc\u03b5\u03c3\u03bf\u03bb\u03b1\u03b2\u03ce\u03bd\u03c4\u03b1\u03c2 \u03ac\u03bc\u03b5\u03c3\u03b1 \u03c3\u03c4\u03b7\u03bd \u03b5\u03bd\u03b4\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03b9\u03b1 \u03c3\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03cc\u03c4\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03bf\u03c1\u03bc\u03bf\u03bd\u03ce\u03bd \u03c4\u03bf\u03c5 \u03c6\u03cd\u03bb\u03bf\u03c5.<\/p>\n

      \u039f \u03ba\u03b1\u03c6\u03ad\u03c2 \u03cc\u03bc\u03c9\u03c2 \u03ad\u03c7\u03b5\u03b9 \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03ba\u03c5\u03ba\u03bb\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03c0\u03b5\u03c1\u03b9\u03cc\u03b4\u03bf\u03c5. \u038c\u03c0\u03c9\u03c2 \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf\u03bd \u03c0\u03b1\u03c1\u03b1\u03ba\u03ac\u03c4\u03c9 \u03c0\u03af\u03bd\u03b1\u03ba\u03b1, \u03ba\u03b1\u03c4\u03b1\u03bd\u03ac\u03bb\u03c9\u03c3\u03b7 >200 mg \u03ba\u03b1\u03c6\u03b5\u03af\u03bd\u03b7\u03c2\/\u03b7\u03bc., \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03bf\u03bd \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03c3\u03c5\u03c7\u03bd\u03bf\u03bc\u03b7\u03bd\u03cc\u03c1\u03c1\u03bf\u03b9\u03b1\u03c2 \u03ba\u03b1\u03c4\u03ac 50% \u03ba\u03b1\u03b9 \u03b1\u03c1\u03b1\u03b9\u03bf\u03bc\u03b7\u03bd\u03cc\u03c1\u03c1\u03bf\u03b9\u03b1\u03c2 \u03ba\u03b1\u03c4\u03ac 38% (40).<\/p>\n

      \u03a0\u03af\u03bd\u03b1\u03ba\u03b1\u03c2 1. <\/b>\u039a\u03b1\u03c4\u03b1\u03bd\u03ac\u03bb\u03c9\u03c3\u03b7 \u03ba\u03b1\u03c6\u03ad \u03ba\u03b1\u03b9 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ad\u03c2 \u03ad\u03bc\u03bc\u03b7\u03bd\u03b7\u03c2 \u03c1\u03cd\u03c3\u03b7\u03c2.<\/p>\n\n\n\n\n\n\n\n
      Caffeine (mg\/\u03b7\u03bc)<\/b><\/span><\/td>\n\n

      \u0392\u03c1\u03b1\u03c7\u03cd\u03c2 \u03ba\u03cd\u03ba\u03bb\u03bf\u03c2
      \n\u226425 \u03b7\u03bc \u039d \u03ba\u03b1\u03b9 %<\/b><\/span><\/p>\n<\/td>\n

      		\n

      RR<\/b><\/span><\/p>\n<\/td>\n

      		\n

      \u039c\u03b5\u03b3\u03ac\u03bb\u03bf\u03c2 \u03ba\u03cd\u03ba\u03bb\u03bf\u03c2
      \n\u2265 33 \u03b7\u03bc \u039d \u03ba\u03b1\u03b9 %<\/b><\/span><\/p>\n<\/td>\n

      		\n

      RR<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n

      <100<\/b><\/td>\n\n

      71 (6,9)<\/p>\n<\/td>\n

      		\n

      1,00<\/p>\n<\/td>\n

      		\n

      76 (7,4)<\/p>\n<\/td>\n

      		\n

      1,00<\/p>\n<\/td>\n<\/tr>\n

      100\u2013199<\/b><\/td>\n\n

      30 (7,8)<\/p>\n<\/td>\n

      		\n

      1,10<\/p>\n<\/td>\n

      		\n

      21 (5,4)<\/p>\n<\/td>\n

      		\n

      0,78<\/p>\n<\/td>\n<\/tr>\n

      200\u2013299<\/b><\/td>\n\n

      21 (10,3)<\/p>\n<\/td>\n

      		\n

      1,50<\/p>\n<\/td>\n

      		\n

      16 (7,9)<\/p>\n<\/td>\n

      		\n

      1,38<\/p>\n<\/td>\n<\/tr>\n

      >300<\/b><\/td>\n\n

      17 (9,9)<\/p>\n<\/td>\n

      		\n

      1,36<\/p>\n<\/td>\n

      		\n

      11 (6,4)<\/p>\n<\/td>\n

      		\n

      1,16<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

      5.2. \u0397 \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c6\u03ad \u03c3\u03c4\u03bf \u03c3\u03c4\u03c1\u03b5\u03c2<\/b><\/h5>\n

      \u0397 \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03c4\u03bf\u03bd \u03ac\u03be\u03bf\u03bd\u03b1 \u03c4\u03bf\u03c5 \u03c3\u03c4\u03c1\u03b5\u03c2, \u03b1\u03c5\u03be\u03ac\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03b3\u03bb\u03c5\u03ba\u03bf\u03ba\u03bf\u03c1\u03c4\u03b9\u03ba\u03bf\u03b5\u03b9\u03b4\u03ce\u03bd \u03ba\u03b1\u03b9 \u03ba\u03b1\u03c4\u03b5\u03c7\u03bf\u03bb\u03b1\u03bc\u03b9\u03bd\u03ce\u03bd, \u03bc\u03b5 \u03b1\u03c0\u03cc\u03c4\u03bf\u03ba\u03bf \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03c1\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae\u03c2 \u03c0\u03af\u03b5\u03c3\u03b7\u03c2.<\/p>\n

      \u039c\u03b5\u03bb\u03ad\u03c4\u03b7 \u03c3\u03b5 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03c0\u03bf\u03c5 \u03ad\u03c0\u03b9\u03bd\u03b1\u03bd \u03c4\u03b9\u03c2 \u03c3\u03c5\u03bd\u03ae\u03b8\u03b5\u03b9\u03c2 \u03c0\u03bf\u03c3\u03cc\u03c4\u03b7\u03c4\u03b5\u03c2 \u03ba\u03b1\u03c6\u03ad \u03ba\u03b1\u03b9 \u03b4\u03b5\u03bd \u03ba\u03ac\u03c0\u03bd\u03b9\u03b6\u03b1\u03bd \u03ad\u03b4\u03b5\u03b9\u03be\u03b5 \u03cc\u03c4\u03b9 (41):<\/p>\n

      \u0397 \u03c0\u03c1\u03cc\u03c3\u03bb\u03b7\u03c8\u03b7 \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7\u03c2 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03c4\u03b7 \u03bc\u03ad\u03c3\u03b7 \u03b1\u03c1\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae \u03c0\u03af\u03b5\u03c3\u03b7 \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7 \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03c4\u03c9\u03bd \u03b5\u03c1\u03b3\u03ac\u03c3\u03b9\u03bc\u03c9\u03bd \u03c9\u03c1\u03ce\u03bd, \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7\u03bd \u03b5\u03c1\u03b3\u03b1\u03c3\u03af\u03b1, \u03bc\u03b5 \u03c0\u03b1\u03c1\u03ac\u03bb\u03bb\u03b7\u03bb\u03b7 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03ba\u03b1\u03c4\u03ac 32% \u03c4\u03c9\u03bd \u03b5\u03c0\u03b9\u03c0\u03ad\u03b4\u03c9\u03bd \u03c4\u03b7\u03c2 \u03b5\u03bb\u03b5\u03cd\u03b8\u03b5\u03c1\u03b7\u03c2 \u03b5\u03c0\u03b9\u03bd\u03b5\u03c6\u03c1\u03af\u03bd\u03b7\u03c2.\u0395\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd, \u03b7 \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7 \u03b5\u03c0\u03b9\u03b2\u03b1\u03c1\u03cd\u03bd\u03b5\u03b9 \u03c4\u03b9\u03c2 \u03c0\u03c1\u03bf\u03c3\u03b1\u03c1\u03bc\u03bf\u03c3\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b1\u03c5\u03be\u03ae\u03c3\u03b5\u03b9\u03c2 \u03c4\u03b7\u03c2 \u03b1\u03c1\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae \u03c0\u03af\u03b5\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03ba\u03bf\u03cd \u03c1\u03c5\u03b8\u03bc\u03bf\u03cd \u03c0\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b4\u03ad\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03bf \u03b5\u03c0\u03b1\u03b3\u03b3\u03b5\u03bb\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc \u03c3\u03c4\u03c1\u03b5\u03c2.<\/p>\n

      \u03a3\u03b5 47 \u03c5\u03b3\u03b9\u03b5\u03af\u03c2 \u03bd\u03b5\u03b1\u03c1\u03bf\u03cd\u03c2 \u03b5\u03bd\u03ae\u03bb\u03b9\u03ba\u03b5\u03c2 \u03ac\u03bd\u03b4\u03c1\u03b5\u03c2 \u03bc\u03b5\u03bb\u03b5\u03c4\u03ae\u03b8\u03b7\u03ba\u03b1\u03bd \u03bf\u03b9 \u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c4\u03b7\u03c2 \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf \u03c3\u03c4\u03cc\u03bc\u03b1 \u03c3\u03b5 \u03b4\u03cc\u03c3\u03b7 3,3 mg\/\u03ba\u03bb, \u03c0\u03bf\u03c5 \u03b1\u03bd\u03c4\u03b9\u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af \u03c3\u03b5 2-3 \u03c6\u03bb\u03b9\u03c4\u03b6\u03ac\u03bd\u03b9\u03b1 \u03ba\u03b1\u03c6\u03ad, \u03c3\u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03b7\u03c2 ACTH \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03ba\u03bf\u03c1\u03c4\u03b9\u03b6\u03cc\u03bb\u03b7\u03c2. \u039c\u03b5\u03c4\u03ac \u03c4\u03b7\u03bd \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7, \u03b7 ACTH \u03ae\u03c4\u03b1\u03bd \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b1 \u03c3\u03b5 \u03cc\u03bb\u03b5\u03c2 \u03c4\u03b9\u03c2 \u03bb\u03ae\u03c8\u03b5\u03b9\u03c2, \u03b1\u03c0\u03cc \u03c4\u03b1 30 \u03bb\u03b5\u03c0\u03c4\u03ac \u03ad\u03c9\u03c2 \u03c4\u03b1 180 \u03bb\u03b5\u03c0\u03c4\u03ac \u03ba\u03b1\u03b9 \u03b7 \u03ba\u03bf\u03c1\u03c4\u03b9\u03b6\u03cc\u03bb\u03b7 \u03b1\u03c5\u03be\u03ae\u03b8\u03b7\u03ba\u03b5 \u03b1\u03c0\u03cc \u03c4\u03b1 60 \u03bb\u03b5\u03c0\u03c4\u03ac \u03ad\u03c9\u03c2 \u03c4\u03b1 120 \u03bb\u03b5\u03c0\u03c4\u03ac. \u0397 \u03bc\u03ad\u03b3\u03b9\u03c3\u03c4\u03b7 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c3\u03b5 \u03c3\u03c7\u03ad\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03bf \u03b5\u03b9\u03ba\u03bf\u03bd\u03b9\u03ba\u03cc \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf \u03ae\u03c4\u03b1\u03bd \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd ACTH, 33% (5,2 pg \/ ml) \u03ba\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03ba\u03bf\u03c1\u03c4\u03b9\u03b6\u03cc\u03bb\u03b7 30% (2,7 \u03bc\u03b9\u03ba\u03c1\u03bf\u03b3\u03c1\u03b1\u03bc\u03bc\u03ac\u03c1\u03b9\u03b1 \/ dl) 60\u2019 \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7 \u03bb\u03ae\u03c8\u03b7 \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7\u03c2.<\/p>\n

      \u03a4\u03b1 \u03b5\u03c5\u03c1\u03ae\u03bc\u03b1\u03c4\u03b1 \u03b1\u03c5\u03c4\u03ac \u03b4\u03b5\u03af\u03c7\u03bd\u03bf\u03c5\u03bd \u03cc\u03c4\u03b9 \u03b7 \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03ae\u03c3\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2 \u03c4\u03bf\u03c5 \u03c3\u03c4\u03c1\u03b5\u03c2 \u03cc\u03c0\u03c9\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf \u03c6\u03bb\u03bf\u03b9\u03bf-\u03b5\u03c0\u03b9\u03bd\u03b5\u03c6\u03c1\u03b9\u03b4\u03b9\u03ba\u03cc\u03c2 \u03ac\u03be\u03bf\u03bd\u03b1\u03c2. \u0397 \u03b4\u03c1\u03ac\u03c3\u03b7 \u03b1\u03c5\u03c4\u03ae \u03c4\u03b7\u03c2 \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7\u03c2 \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03bf\u03c6\u03b5\u03af\u03bb\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03ad\u03ba\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2 ACTH \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03c5\u03c0\u03cc\u03c6\u03c5\u03c3\u03b7 (42).
      \n<\/b><\/p>\n

      6. \u03a3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf \u03c3\u03c4\u03ad\u03c1\u03b7\u03c3\u03b7\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7<\/b><\/h4>\n

      \u038c\u03c0\u03c9\u03c2 \u03cc\u03bb\u03b5\u03c2 \u03bf\u03b9 \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bf\u03c5\u03c3\u03af\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03b4\u03c1\u03bf\u03c5\u03bd \u03c3\u03c4\u03bf \u039a\u039d\u03a3 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7\u03c2 \u03b5\u03be\u03ac\u03c1\u03c4\u03b7\u03c3\u03b7\u03c2, \u03ad\u03c4\u03c3\u03b9 \u03ba\u03b1\u03b9 \u03b7 \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03b5\u03b9 \u03c6\u03b1\u03b9\u03bd\u03cc\u03bc\u03b5\u03bd\u03b1 \u03b5\u03be\u03ac\u03c1\u03c4\u03b7\u03c3\u03b7\u03c2 \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03b7\u03bd \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7 \u03c3\u03c5\u03bc\u03c0\u03c4\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7 \u03b4\u03b9\u03b1\u03ba\u03bf\u03c0\u03ae \u03c4\u03b7\u03c2.<\/p>\n

      \u03a4\u03bf \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf \u03c3\u03c4\u03ad\u03c1\u03b7\u03c3\u03b7\u03c2 \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7\u03c2 \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1 \u03c0\u03bf\u03c5 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03ad\u03c9\u03c2 \u03ba\u03b1\u03b9 48 \u03ce\u03c1\u03b5\u03c2 \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7 \u03b4\u03b9\u03b1\u03ba\u03bf\u03c0\u03ae \u03ae \u03b1\u03ba\u03cc\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b7 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c0\u03c1\u03cc\u03c3\u03bb\u03b7\u03c8\u03b7\u03c2, \u03ad\u03c3\u03c4\u03c9 \u03ba\u03b1\u03b9 \u03c4\u03c9\u03bd \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03bd \u03c0\u03bf\u03c3\u03bf\u03c4\u03ae\u03c4\u03c9\u03bd \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7\u03c2.\u00a0 \u03a4\u03b1 \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1 \u03b1\u03c5\u03c4\u03ac \u03ba\u03bf\u03c1\u03c5\u03c6\u03ce\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5\u03c4\u03ac 20 \u03ad\u03c9\u03c2 48 \u03ce\u03c1\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b4\u03b9\u03b1\u03c1\u03ba\u03ad\u03c3\u03bf\u03c5\u03bd \u03b1\u03c0\u03cc \u03bc\u03af\u03b1 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b1 \u03ad\u03c9\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03c1\u03ba\u03b5\u03c4\u03bf\u03cd\u03c2 \u03bc\u03ae\u03bd\u03b5\u03c2 \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u03c4\u03b7 \u03b4\u03b9\u03b1\u03ba\u03bf\u03c0\u03ae \u03c4\u03b7\u03c2. \u03a4\u03b1 \u03c6\u03b1\u03b9\u03bd\u03cc\u03bc\u03b5\u03bd\u03b1 \u03c3\u03c4\u03ad\u03c1\u03b7\u03c3\u03b7\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c0\u03c1\u03bf\u03bb\u03b7\u03c6\u03b8\u03bf\u03cd\u03bd \u03ae \u03bd\u03b1 \u03b1\u03c0\u03bf\u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03b1\u03b8\u03bf\u03cd\u03bd \u03ac\u03bc\u03b5\u03c3\u03b1 \u03bc\u03b5\u03c4\u03ac \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03ad\u03c3\u03c4\u03c9 \u03ba\u03b1\u03b9 25 mg \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7\u03c2.<\/p>\n

      \u03a3\u03b5 \u03bc\u03b9\u03b1 \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b1\u03bd\u03b1\u03c3\u03ba\u03cc\u03c0\u03b7\u03c3\u03b7 66 \u03c0\u03b5\u03b9\u03c1\u03b1\u03bc\u03b1\u03c4\u03b9\u03ba\u03ce\u03bd \u03bc\u03b5\u03bb\u03b5\u03c4\u03ce\u03bd \u03c0\u03bf\u03c5 \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03bf\u03c0\u03bf\u03b9\u03ae\u03b8\u03b7\u03ba\u03b1\u03bd \u03bc\u03b5\u03c4\u03b1\u03be\u03cd 1872 \u03ba\u03b1\u03b9 2004, \u03bf\u03b9 Juliano \u03ba\u03b1\u03b9 Griffiths \u03ba\u03b1\u03c4\u03ad\u03bb\u03b7\u03be\u03b1\u03bd \u03c3\u03c4\u03b1 \u03b5\u03be\u03ae\u03c2 \u03c3\u03c4\u03b5\u03c1\u03b7\u03c4\u03b9\u03ba\u03ac \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7 \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1: \u03c0\u03bf\u03bd\u03bf\u03ba\u03ad\u03c6\u03b1\u03bb\u03bf\u03c2, \u03ba\u03cc\u03c0\u03c9\u03c3\u03b7, \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03b5\u03bd\u03b5\u03c1\u03b3\u03b7\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2, \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03b5\u03b3\u03c1\u03ae\u03b3\u03bf\u03c1\u03c3\u03b7\u03c2, \u03c5\u03c0\u03bd\u03b7\u03bb\u03af\u03b1, \u03bc\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03b5\u03c5\u03c7\u03b1\u03c1\u03af\u03c3\u03c4\u03b7\u03c3\u03b7, \u03ba\u03b1\u03c4\u03b1\u03b8\u03bb\u03b9\u03c0\u03c4\u03b9\u03ba\u03ae \u03b4\u03b9\u03ac\u03b8\u03b5\u03c3\u03b7, \u03b4\u03c5\u03c3\u03ba\u03bf\u03bb\u03af\u03b1 \u03c3\u03c4\u03b7 \u03c3\u03c5\u03b3\u03ba\u03ad\u03bd\u03c4\u03c1\u03c9\u03c3\u03b7, \u03b5\u03c5\u03b5\u03c1\u03b5\u03b8\u03b9\u03c3\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1, \u03b8\u03bf\u03bb\u03ae \u03b1\u03bd\u03c4\u03af\u03bb\u03b7\u03c8\u03b7, \u03b3\u03c1\u03b9\u03c0\u03ce\u03b4\u03b7 \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1, \u03bd\u03b1\u03c5\u03c4\u03af\u03b1\u00a0 \u03ba\u03b1\u03b9 \u03ad\u03bc\u03b5\u03c4\u03bf\u03c2, \u03bc\u03c5\u03b1\u03bb\u03b3\u03af\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03b4\u03c5\u03c3\u03ba\u03b1\u03bc\u03c8\u03af\u03b1 (43).<\/p>\n

      \u0391\u03bd \u03ba\u03b1\u03b9 \u03c4\u03bf \u03c3\u03cd\u03bc\u03c0\u03c4\u03c9\u03bc\u03b1 \u03c4\u03bf\u03c5 \u03ac\u03b3\u03c7\u03bf\u03c5\u03c2 \u03b4\u03b5\u03bd \u03ad\u03c7\u03b5\u03b9 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b7\u03c6\u03b8\u03b5\u03af \u03c3\u03b5 \u03b1\u03c5\u03c4\u03ae \u03c4\u03b7\u03bd \u03b1\u03bd\u03b1\u03c3\u03ba\u03cc\u03c0\u03b7\u03c3\u03b7, \u03b7 \u0391\u03bc\u03b5\u03c1\u03b9\u03ba\u03b1\u03bd\u03b9\u03ba\u03ae \u03a8\u03c5\u03c7\u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u0388\u03bd\u03c9\u03c3\u03b7 \u03c3\u03c4\u03b1 \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ac \u03ba\u03c1\u03b9\u03c4\u03ae\u03c1\u03b9\u03b1 DSM-IV-TR \u03c0\u03c1\u03bf\u03c4\u03b5\u03af\u03bd\u03b5\u03b9 \u03ba\u03b1\u03b9 \u03b1\u03c5\u03c4\u03cc \u03c9\u03c2 \u03c3\u03cd\u03bc\u03c0\u03c4\u03c9\u03bc\u03b1 \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b4\u03c1\u03cc\u03bc\u03bf\u03c5 \u03c3\u03c4\u03ad\u03c1\u03b7\u03c3\u03b7\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7.<\/p>\n

      \u0391\u03b9\u03c4\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac, \u03b7 \u03ba\u03c5\u03c1\u03af\u03b1\u03c1\u03c7\u03b7 \u03c5\u03c0\u03cc\u03b8\u03b5\u03c3\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03c0\u03af\u03c3\u03c9 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03c6\u03b1\u03b9\u03bd\u03cc\u03bc\u03b5\u03bd\u03b1 \u03b1\u03c0\u03cc\u03c3\u03c5\u03c1\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7\u03c2 \u03ba\u03c1\u03cd\u03b2\u03b5\u03c4\u03b1\u03b9 \u03c4\u03bf \u03b1\u03b4\u03c1\u03b5\u03bd\u03b5\u03c1\u03b3\u03b9\u03ba\u03cc \u03c3\u03cd\u03c3\u03c4\u03b7\u03bc\u03b1.\u03a0\u03b9\u03c3\u03c4\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03b7 \u03c3\u03c5\u03bd\u03ae\u03b8\u03b7\u03c2 \u03ba\u03b1\u03c4\u03b1\u03bd\u03ac\u03bb\u03c9\u03c3\u03b7 \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7\u03c2, \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03b1\u03bd\u03c4\u03b1\u03b3\u03c9\u03bd\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c4\u03bf\u03c5\u03c2 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03b5\u03af\u03c2 \u03b1\u03b4\u03b5\u03bd\u03bf\u03c3\u03af\u03bd\u03b7\u03c2, \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03b5 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03ae\u03c2 \u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03af\u03b1\u03c2 \u03b1\u03c5\u03c4\u03ce\u03bd \u03c0\u03c1\u03bf\u03c2 \u03c4\u03b7\u03bd \u03b1\u03b4\u03b5\u03bd\u03bf\u03c3\u03af\u03bd\u03b7 \u03ba\u03b1\u03b9 \u03b5\u03c0\u03bf\u03bc\u03ad\u03bd\u03c9\u03c2 \u03b7 \u03c5\u03c0\u03b5\u03c1\u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03af\u03b1 \u03c3\u03c4\u03b7\u03bd \u03b1\u03b4\u03b5\u03bd\u03bf\u03c3\u03af\u03bd\u03b7\u03c2 \u03c3\u03c4\u03b7 \u03c6\u03ac\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03c0\u03bf\u03c7\u03ae\u03c2 \u03b8\u03b1 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03c3\u03b5 \u03bd\u03b1 \u03b4\u03b9\u03ba\u03b1\u03b9\u03bf\u03bb\u03bf\u03b3\u03ae\u03c3\u03b5\u03b9 \u03c4\u03b1 \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1 \u03c3\u03c4\u03ad\u03c1\u03b7\u03c3\u03b7\u03c2 (44).<\/p>\n

      \u03a4\u03bf \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf \u03c3\u03c4\u03ad\u03c1\u03b7\u03c3\u03b7\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03ba\u03b1\u03c6\u03b5\u0390\u03bd\u03b7 \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd \u03a0\u039f\u03a5 \u03c3\u03c4\u03bf ICD-10 \u03c9\u03c2 \u03b5\u03c0\u03af\u03c3\u03b7\u03bc\u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7.<\/p>\n

      \u0392\u03b9\u03b2\u03bb\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1
      \n<\/b><\/h4>\n
        \n
      1. Verlengia F, Rigitano A, et al. Variations of the caffeine content in coffee beverages. ASIC, 2nd Int Sci Colloq Green and Roasted Coffee Chem. 1965, 106\u2013114.<\/li>\n
      2. Di Castelnuovo A, di Giuseppe R et al. Consumption of cocoa, tea and coffee and risk of cardiovascular disease. Eur J Intern Med. 2012, 23(1):15-25.<\/li>\n
      3. Zampelas A, Panagiotakos DB, et al. Associations between coffee consumption and inflammatory markers in healthy persons: the ATTICA study. Am J Clin Nutr. 2004, 80(4):862-7.<\/li>\n
      4. Higgins, H. L., and J. H. Means. The effect ofcertain drugs on the respiration and gaseous metabolism in normal human subjects. J. Pharmacol.Exptl. Therap. 1915, 7: 1<\/li>\n
      5. Acheson K.J, Zahorska-Markiewicz B., et al. Caffeine and coffee: their influence on metabolicrate and substrate utilization in normal weightand obese individuals1. Am. I Clin. Nuir.1980, 33: 989-997<\/li>\n
      6. Fredholm, B.B., On the Mechanism of Action of Theophylline and Caffeine. Acta Medica Scandinavica, 1985, 217(2):149-153.<\/li>\n
      7. Benowitz, N.L., Clinical pharmacology of caffeine. Annual Review of Medicine, 1990. 41:277-288.<\/li>\n
      8. Hursel R, Viechtbauer W, Dulloo AG et al. The effects of catechin rich teas and caffeine on energy expenditure and fat oxidation: a meta-analysis. Obes Rev. 2011;12 (7):573-81<\/li>\n
      9. Fern\u00e1ndez-El\u00edas VE, Del Coso J, Hamouti N. et al. Ingestion of a Moderately-High Caffeine Dose Before Exercise Increases Post-Exercise Energy Expenditure. Int J Sport Nutr Exerc Metab. 2014 Jun 5.<\/li>\n
      10. Jungas RL, Ball EG. Studies on the metabolism of adipose tissue. XII. The effects of insulin and epinephrine on free fatty acid and glycerol production in the presence and absence of glucose. Biochemistry 1963;2:383\u2013 8.<\/li>\n
      11. Bracco D, Ferrarra JM, et al. Effects of caffeine on energy metabolism, heart rate, and methylxanthine metabolism in lean and obese women. Am J Physiol 1995;269:E671\u2013 8.<\/li>\n
      12. Cheung WT, Lee CM, Ng TB. Potentiation of the antioipolytic effect of2-chloroadenosine after chronic caffeine treatment. Pharmacology1988;36:331\u20139.<\/li>\n
      13. Su SH, Shyu HW et al. Caffeine inhibits adipogenic differentiation of primary adipose-derived stem cells and bone marrow stromal cells. Toxicol In Vitro. 2013;27(6):1830-7<\/li>\n
      14. Acheson KJ, Zahorska-Markiewicz B, et al. Caffeine and coffee: their influence on metabolic rate and substrate utilization in normal weight and obese individuals. Am J Clin Nutr 1980;33:989 \u201397.<\/li>\n
      15. Arciero PJ, Gardner AW, et al. Effects of caffeine ingestion on NE kinetics, fat oxidation, and energy expenditure in younger and older men. Am J Physiol 1995;268(6 Pt 1):E1192\u2013 8.<\/li>\n
      16. Gavrieli A, Karfopoulou E, Kardatou E et al. Effect of different amounts of coffee on dietary intake and appetite of normal-weight and overweight\/obese individuals. Obesity (Silver Spring). 2013;21(6):1127-32.<\/li>\n
      17. Greenberg JA, Geliebter A. Coffee, hunger, and peptide YY. J Am Coll Nutr. 2012 Jun;31(3):160-6<\/li>\n
      18. Huxley R, Lee CM, et al Coffee, decaffeinated coffee, and tea consumption in relation to incident type 2 diabetes mellitus: a systematic review with meta-analysis. Arch Intern Med. 2009, 14;169(22):2053-63.<\/li>\n
      19. Panagiotakos DB, Lionis C, et al. Long-term, moderate coffee consumption is associated with lower prevalence of diabetes mellitus among elderly non-tea drinkers from the Mediterranean Islands (MEDIS Study). Rev Diabet Stud. 2007 Summer;4(2):105-11.<\/li>\n
      20. Greenberg J, Boozer C, Geliebte A. Coffee, diabetes, and weight control. Am J Clin Nutr 2006;84:682\u201393.<\/li>\n
      21. Battram DS, Arthur R, Weekes A, Graham T. The glucose intolerance induced by caffeinated coffee ingestion is less pronounced than that due to alkaloid caffeine in men. J Nutr 2006;136:1276\u201380.<\/li>\n
      22. Thong FS, Derave W, Kiens B, et al. Caffeine-induced impairment ofinsulin action but not insulin signaling in human skeletal muscle isreduced by exercise. Diabetes 2002;51:583\u201390.<\/li>\n
      23. Thong FS, Graham TE. Caffeine-induced impairment of glucose tolerance is abolished by beta-adrenergic receptor blockade in humans, J Appl Physiol 2002;92:2347\u201352.<\/li>\n
      24. Beaudoin MS, Allen B, Mazzetti G, et al. Caffeine ingestion impairs insulin sensitivity in a dose-dependent manner in both men and women. Appl Physiol Nutr Metab. 2013;38(2):140-7<\/li>\n
      25. Van Dam RM, Hu FB. Coffee Consumption and risk of type 2 diabetes: a systematic review. JAMA 2005;294:97\u2013104.<\/li>\n
      26. Urgert R, Katan MB. The cholesterol-raising factor from coffee beans. Annu Rev Nutr 1997;17:305\u201324.<\/li>\n
      27. Bak AA, Grobbee DE. The effect on serum cholesterol levels of coffee brewed by filtering or boiling. N Engl J Med 1989;321:1432\u20137.<\/li>\n
      28. Jee SH, He J, Appel LJ, et al. Coffee consumption and serum lipids: a meta-analysis of randomized controlled clinical trials. Am J Epidemiol 2001;153:353\u201362.<\/li>\n
      29. Cai L, Ma D, Zhang Y, et al. The effect of coffee consumption on serum lipids: a meta-analysis of randomized controlled trials. Eur J Clin Nutr. 2012, 66(8):872-7<\/li>\n
      30. Lopez-Garcia E, van Dam RM, et al. Coffee consumption and coronary heart disease in men and women: a prospective cohort study. Circulation 2006;113:2045\u201353.<\/li>\n
      31. Ricketts ML, Boekschoten MV, Kreeft AJ, et al. The cholesterol-raising factor from coffee beans, cafestol, as an agonist ligand for the farnesoid and pregnane X receptors. Mol Endocrinol 2007;21:1603\u201316.<\/li>\n
      32. Miao YL, Shi LH, Lei ZL, et al. Effects of caffeine on in vivo and in vitro oocyte maturation in mice. Theriogenology 2007;68:640\u20135.<\/li>\n
      33. Yen SSC, Strauss JF, Barbieri RL. Yen and Jaffe\u2019s reproductive endocrinology: physiology, pathophysiology, and clinical management. 5th ed. Philadelphia, PA: Elsevier\/Saunders, 2004.<\/li>\n
      34. Lucero J, Harlow BL, et al. Early follicularphase hormone levels in relation to patterns of alcohol, tobacco,and coffee use. Fertil Steril 2001;76:723\u20139.<\/li>\n
      35. Kinney A, Kline J, et al. Smoking, alcohol andcaffeine in relation to ovarian age during the reproductive years. HumReprod 2007;22:1175\u201385.<\/li>\n
      36. Kotsopoulos J, Eliassen AH, et al. Relationship between caffeine intake and plasma sex hormone concentrations in premenopausal and postmenopausal women. Cancer2009;115:2765\u201374.<\/li>\n
      37. Palacios N, Weisskopf M, et al. Polymorphisms of caffeine metabolism and estrogen receptor genes and risk of Parkinson\u2019s disease in men and women. Parkinsonism Relat Disord 2010;16:370\u20135.<\/li>\n
      38. Schliep K, Schisterman E, Mumford S. et al. Caffeinated beverage intake and reproductive hormones among premenopausal women in the BioCycle Study. Am J Clin Nutr 2012;95:488\u201397.<\/li>\n
      39. Goto \u0391, Song \u03a5, Chen \u0392 et al. Coffee and Caffeine Consumption in Relation to Sex Hormone\u2013Binding Globulin and Risk of Type 2 Diabetes in Postmenopausal Women. Diabetes 2011, 60:269\u2013275<\/li>\n
      40. Hahn \u039a, Wise L, et al. Correlates of menstrual cycle characteristics among nulliparous Danish women. Clinical Epidemiology 2013, 5:311-319<\/li>\n
      41. Lane JD1, Pieper CF, et al. Caffeine affects cardiovascular and neuroendocrine activation at work and home. Psychosom Med. 2002, 64(4):595-603.<\/li>\n
      42. Lovallo WR, Al’Absi M, Blick K, et al. Stress-like adrenocorticotropin responses to caffeine in young healthy men. Pharmacol Biochem Behav. 1996; 55(3):365-9.<\/li>\n
      43. Juliano, L.M. and R.R. Griffiths. A critical review of caffeine withdrawal: Empirical validation of symptoms and signs, incidence, severity, and associated features. Psychopharmacology, 2004. 176(1):1-29.<\/li>\n
      44. Hirsh, K. Central nervous system pharmacology of the dietary methylxanthines. Prog Clin Biol Res, 1984. 158:235-301.<\/li>\n<\/ol>\n
        \n

        Created: February 25, 2015
        \nLast update: February 25, 2015<\/p>\n","protected":false},"excerpt":{"rendered":"

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