\u03a3\u03c4\u03b1 \u03b5\u03c0\u03b9\u03bd\u03b5\u03c6\u03c1\u03af\u03b4\u03b9\u03b1, \u03cc\u03c0\u03bf\u03c5 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03bf\u03c5\u03bd \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03cd\u03c2 \u03c0\u03b1\u03bb\u03af\u03bd\u03b4\u03c1\u03bf\u03bc\u03b7\u03c2 \u03b1\u03bb\u03bb\u03b7\u03bb\u03bf\u03c1\u03cd\u03b8\u03bc\u03b9\u03c3\u03b7\u03c2.<\/li>\n<\/ul>\n\u039a\u03b1\u03b9 \u03b1\u03bd\u03b1\u03bb\u03c5\u03c4\u03b9\u03ba\u03cc\u03c4\u03b5\u03c1\u03b1: \u03a3\u03c4\u03b1 \u03c4\u03c1\u03c9\u03ba\u03c4\u03b9\u03ba\u03ac \u03b7 \u03bf\u03be\u03b5\u03af\u03b1 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u0391\u0391\u00a0 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03b7\u03c2 ACTH \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03ba\u03bf\u03c1\u03c4\u03b9\u03ba\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7\u03c2 \u03bc\u03b5 \u03bc\u03af\u03b1 \u03b4\u03bf\u03c3\u03bf-\u03b5\u03be\u03b1\u03c1\u03c4\u03ce\u03bc\u03b5\u03bd\u03b7 \u03b1\u03c0\u03ac\u03bd\u03c4\u03b7\u03c3\u03b7, \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b9\u03bf \u03bc\u03b5\u03b3\u03ac\u03bb\u03b7 \u03c3\u03c4\u03b1 \u03b8\u03ae\u03bb\u03b5\u03b1 \u03c0\u03b5\u03b9\u03c1\u03b1\u03bc\u03b1\u03c4\u03cc\u03b6\u03c9\u03b1 (3). \u0397 \u03b4\u03c1\u03ac\u03c3\u03b7 \u03b1\u03c5\u03c4\u03ae \u03c4\u03b7\u03c2 \u0391\u0391 \u03bf\u03c6\u03b5\u03af\u03bb\u03b5\u03c4\u03bf \u03c3\u03c4\u03b7\u03bd \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03ad\u03ba\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2 CRH \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd \u03c5\u03c0\u03bf\u03b8\u03ac\u03bb\u03b1\u03bc\u03bf, \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03b2\u03b1\u03b6\u03bf\u03c0\u03c1\u03b5\u03c3\u03af\u03bd\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03b9\u03bb\u03b9\u03b1\u03ba\u03bf\u03cd \u03c0\u03c5\u03c1\u03ae\u03bd\u03b1 \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03b1\u03c5\u03c4\u03ae\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03ac\u03b3\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03ac\u03bb\u03bb\u03bf\u03c5\u03c2 \u03c3\u03c7\u03b7\u03bc\u03b1\u03c4\u03b9\u03c3\u03bc\u03bf\u03cd\u03c2 \u03c4\u03bf\u03c5 \u039a\u039d\u03a3 (4). \u03a3\u03c4\u03b1 \u03c0\u03b5\u03b9\u03c1\u03b1\u03bc\u03b1\u03c4\u03cc\u03b6\u03c9\u03b1 \u03c0\u03bf\u03c5 \u03ae\u03c4\u03b1\u03bd knockout\u00a0 \u03c3\u03c4\u03b7\u03bd CRH\u00a0 \u03ba\u03b1\u03b9 \u03b5\u03be\u03b1\u03c1\u03c4\u03b7\u03bc\u03ad\u03bd\u03b1 \u03c3\u03c4\u03b7\u03bd \u0391\u0391, \u03b7 \u03c0\u03c1\u03cc\u03c3\u03bb\u03b7\u03c8\u03b7 \u03b4\u03b9\u03c0\u03bb\u03ac\u03c3\u03b9\u03b1\u03c2 \u03c0\u03bf\u03c3\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u0391\u0391 \u03b5\u03af\u03c7\u03b5 \u03b5\u03bb\u03ac\u03c7\u03b9\u03c3\u03c4\u03b5\u03c2 \u03b5\u03c0\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c3\u03c4\u03b7 \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03c6\u03bf\u03c1\u03ac \u03c4\u03bf\u03c5 \u03c4\u03c1\u03c9\u03ba\u03c4\u03b9\u03ba\u03bf\u03cd (5). \u03a4\u03bf \u03b5\u03bd\u03b4\u03b9\u03b1\u03c6\u03ad\u03c1\u03bf\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03c3\u03b5 \u03b5\u03be\u03b1\u03c1\u03c4\u03b7\u03bc\u03ad\u03bd\u03b1 \u03c0\u03b5\u03b9\u03c1\u03b1\u03bc\u03b1\u03c4\u03cc\u03b6\u03c9\u03b1, \u03b7 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03bb\u03ae\u03c8\u03b7 \u0391\u0391 \u03b5\u03af\u03c7\u03b5 \u03c9\u03c2 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03b7 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c5\u03c0\u03bf\u03b8\u03b1\u03bb\u03b1\u03bc\u03b9\u03ba\u03bf\u03cd mRNA \u03c4\u03b7\u03c2 CRH \u03ba\u03b1\u03b8\u03ce\u03c2 \u03ba\u03b1\u03b9 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03c0\u03ac\u03bd\u03c4\u03b7\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03c5\u03c0\u03bf\u03c6\u03c5\u03c3\u03b9\u03b1\u03ba\u03ae\u03c2 ACTH \u03c3\u03c4\u03b7\u03bd CRH (6, 7).\u03a4\u03b1 \u03c7\u03b1\u03bc\u03b7\u03bb\u03ac \u03b1\u03c5\u03c4\u03ac \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 CRH \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03bf\u03c7\u03ae \u03c3\u03c4\u03b7\u03bd \u03b5\u03be\u03ac\u03c1\u03c4\u03b7\u03c3\u03b7 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u0391\u0391.<\/p>\n
\u03a0\u03bf\u03bb\u03bb\u03ad\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c3\u03b5 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03bf\u03c5\u03c2 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b4\u03b5\u03af\u03be\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03b7 \u0391\u0391 \u03ad\u03c7\u03b5\u03b9 \u03c0\u03b1\u03c1\u03cc\u03bc\u03bf\u03b9\u03b1 \u03b4\u03b9\u03b5\u03b3\u03b5\u03c1\u03c4\u03b9\u03ba\u03ac \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03c3\u03c4\u03bf\u03bd \u03a5\u03a5\u0395 \u03ac\u03be\u03bf\u03bd\u03b1. \u0389\u03b4\u03b7, \u03b1\u03c0\u03cc \u03c4\u03bf 1968 \u03b4\u03b5\u03af\u03c7\u03c4\u03b7\u03ba\u03b5 \u03cc\u03c4\u03b9, \u03c3\u03b5 \u03c5\u03b3\u03b9\u03ae \u03ac\u03c4\u03bf\u03bc\u03b1 \u03b4\u03cc\u03c3\u03b7 \u0391\u0391 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03b1\u03c0\u03cc 100 mg\/ml \u03b5\u03af\u03c7\u03b5 \u03c9\u03c2 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03b7 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b7 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03ba\u03bf\u03c1\u03c4\u03b9\u03b6\u03cc\u03bb\u03b7\u03c2 \u03c3\u03c4\u03bf \u03b1\u03af\u03bc\u03b1. \u03a3\u03b5 \u03ac\u03bb\u03bb\u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7, \u03b4\u03b5\u03af\u03c7\u03c4\u03b7\u03ba\u03b5 \u03cc\u03c4\u03b9 \u03cc\u03c3\u03bf \u03b1\u03c5\u03be\u03b1\u03bd\u03cc\u03c4\u03b1\u03bd \u03b7 \u03ba\u03b1\u03c4\u03b1\u03bd\u03ac\u03bb\u03c9\u03c3\u03b7 \u0391\u0391, \u03c4\u03cc\u03c3\u03bf \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b1 \u03ae\u03c4\u03b1\u03bd \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03ba\u03bf\u03c1\u03c4\u03b9\u03b6\u03cc\u03bb\u03b7\u03c2 \u03c3\u03c4\u03b1 \u03bf\u03cd\u03c1\u03b1, \u03b5\u03bd\u03ce \u03c0\u03b1\u03c1\u03ac\u03bb\u03bb\u03b7\u03bb\u03b1 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b2\u03b1\u03c1\u03b5\u03af\u03c2 \u03c0\u03cc\u03c4\u03b5\u03c2 \u03ae\u03c4\u03b1\u03bd \u03bc\u03b5\u03b9\u03bf\u03bd\u03b5\u03ba\u03c4\u03b9\u03ba\u03ae \u03ba\u03b1\u03b9 \u03b7 \u03ba\u03b5\u03bd\u03c4\u03c1\u03b9\u03ba\u03ae \u03b1\u03bd\u03b1\u03c3\u03c4\u03b1\u03bb\u03c4\u03b9\u03ba\u03ae \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03ba\u03bf\u03c1\u03c4\u03b9\u03b6\u03cc\u03bb\u03b7\u03c2 \u03c3\u03c4\u03bf\u03bd \u03a5\u03a5\u0395 \u03ac\u03be\u03bf\u03bd\u03b1 (8).<\/p>\n
\u03a3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03cc\u03bc\u03c9\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03b7 \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b5\u03bd\u03b4\u03bf\u03b3\u03b5\u03bd\u03ce\u03bd \u03bf\u03c0\u03b9\u03bf\u03b5\u03b9\u03b4\u03ce\u03bd \u03ba\u03b1\u03b9 \u03c4\u03bf\u03c5 \u03c3\u03c5\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2 \u03b1\u03bd\u03c4\u03b1\u03bc\u03bf\u03b9\u03b2\u03ae\u03c2 \u03c3\u03c4\u03b7 \u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03c4\u03bf\u03c5 \u03a5\u03a5\u0395 \u03ac\u03be\u03bf\u03bd\u03b1.\u03a0\u03b9\u03c3\u03c4\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03b7 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b5\u03bd\u03b4\u03bf\u03b3\u03b5\u03bd\u03ce\u03bd \u03bf\u03c0\u03b9\u03bf\u03b5\u03b9\u03b4\u03ce\u03bd, \u03ac\u03c3\u03c7\u03b5\u03c4\u03b1 \u03b1\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c5\u03b3\u03b3\u03b5\u03bd\u03ae\u03c2 \u03ae \u03b5\u03c0\u03af\u03ba\u03c4\u03b7\u03c4\u03b7 \u03bb\u03cc\u03b3\u03c9 \u03c4\u03bf\u03c5 \u03b1\u03bb\u03ba\u03bf\u03bf\u03bb\u03b9\u03c3\u03bc\u03bf\u03cd, \u03b5\u03c5\u03bd\u03bf\u03b5\u03af \u03c4\u03b7\u03bd \u03c5\u03c0\u03b5\u03c1\u03ba\u03bf\u03c1\u03c4\u03b9\u03b6\u03bf\u03bb\u03b1\u03b9\u03bc\u03af\u03b1, \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03ad\u03ba\u03ba\u03c1\u03b9\u03c3\u03b7 \u03bd\u03c4\u03bf\u03c0\u03b1\u03bc\u03af\u03bd\u03b7\u03c2 \u03c3\u03c4\u03bf \u03bc\u03b5\u03c3\u03bf\u03c6\u03bb\u03bf\u03b9\u03ca\u03ba\u03cc \u03c3\u03cd\u03c3\u03c4\u03b7\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03b5 \u03b1\u03bd\u03ce\u03bc\u03b1\u03bb\u03b7 \u03b5\u03bd\u03af\u03c3\u03c7\u03c5\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b4\u03c1\u03ac\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u0391\u0391 (9, 10).<\/p>\n
\u0395\u03c5\u03c4\u03c5\u03c7\u03ce\u03c2, \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03b7 \u03b4\u03b9\u03b1\u03ba\u03bf\u03c0\u03ae \u03c4\u03b7\u03c2 \u0391\u0391 \u03b1\u03c0\u03bf\u03ba\u03b1\u03b8\u03b9\u03c3\u03c4\u03ac \u03c3\u03b5 \u03bc\u03b5\u03b3\u03ac\u03bb\u03bf \u03b2\u03b1\u03b8\u03bc\u03cc \u03c4\u03bf\u03bd \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03b3\u03bc\u03ad\u03bd\u03bf \u03a5\u03a5\u0395 \u03ac\u03be\u03bf\u03bd\u03b1.\u03a3\u03b5 \u03c0\u03c1\u03cc\u03c3\u03c6\u03b1\u03c4\u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03b4\u03b5\u03af\u03c7\u03c4\u03b7\u03ba\u03b5 \u03cc\u03c4\u03b9 \u03b7 \u03b1\u03bd\u03c4\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b1\u03bb\u03ba\u03bf\u03bf\u03bb\u03b9\u03ba\u03ce\u03bd \u03c3\u03c4\u03bf \u03c8\u03c5\u03c7\u03bf\u03ba\u03bf\u03b9\u03bd\u03c9\u03bd\u03b9\u03ba\u03cc \u03c3\u03c4\u03c1\u03b5\u03c2 (Trier Social Stress Test), \u03bc\u03b5\u03c4\u03ac \u03bc\u03b1\u03ba\u03c1\u03bf\u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03b1\u03c0\u03bf\u03c7\u03ae \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u0391\u0391, \u03ae\u03c4\u03b1\u03bd \u03c0\u03b1\u03c1\u03cc\u03bc\u03bf\u03b9\u03b1 \u03bc\u03b5 \u03b1\u03c5\u03c4\u03ae \u03c4\u03c9\u03bd \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ce\u03bd \u03b1\u03c4\u03cc\u03bc\u03c9\u03bd, \u03c3\u03b5 \u03b1\u03bd\u03c4\u03af\u03b8\u03b5\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03bf\u03c5\u03c2 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03cd\u03c2 \u03c0\u03cc\u03c4\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03b7 \u03b1\u03bd\u03c4\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c3\u03c4\u03bf \u03c4\u03b5\u03c3\u03c4 \u03ae\u03c4\u03b1\u03bd \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03c0\u03b9\u03bf \u03ad\u03bd\u03c4\u03bf\u03bd\u03b7 (11).<\/p>\n
\u038c\u03bb\u03b1 \u03c4\u03b1 \u03c0\u03b1\u03c1\u03b1\u03c0\u03ac\u03bd\u03c9 \u03bf\u03b4\u03ae\u03b3\u03b7\u03c3\u03b1\u03bd \u03c3\u03c4\u03b7\u03bd \u03ba\u03b1\u03b8\u03b9\u03ad\u03c1\u03c9\u03c3\u03b7 \u03c3\u03c4\u03b7 \u03b2\u03b9\u03b2\u03bb\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1 \u03c4\u03bf\u03c5 \u03cc\u03c1\u03bf\u03c5: \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf \u03c8\u03b5\u03cd\u03b4\u03bf-Cushing\u2019s. \u03a4\u03bf \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03cc \u03ba\u03c1\u03b9\u03c4\u03ae\u03c1\u03b9\u03bf \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03c4\u03b5\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b4\u03b9\u03ac\u03ba\u03c1\u03b9\u03c3\u03b7 \u03b1\u03c0\u03cc \u03c4\u03bf \u03b1\u03bb\u03b7\u03b8\u03ad\u03c2 Cushing\u2019s \u03b5\u03af\u03bd\u03b1\u03b9: CRH-test \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u03bc\u03b9\u03ba\u03c1\u03ae \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03bc\u03b5 \u03b4\u03b5\u03be\u03b1\u03bc\u03b5\u03b8\u03b1\u03b6\u03cc\u03bd\u03b7 (2 mg\/\u03b7\u03bc. \u03a7 2 \u03b7\u03bc.). \u0395\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03ba\u03bf\u03c1\u03c4\u03b9\u03b6\u03cc\u03bb\u03b7\u03c2 \u03c3\u03c4\u03bf \u03b1\u03af\u03bc\u03b1 15\u2019 \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 CRH \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b1 \u03b1\u03c0\u03cc 1.4 mg\/dl \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03af\u03b6\u03bf\u03c5\u03bd \u03c0\u03ac\u03bd\u03c4\u03b1 \u03c4\u03bf \u03b1\u03bb\u03b7\u03b8\u03ad\u03c2 \u03c3. Cushing\u2019s (12).\u03a0\u03ac\u03bd\u03c4\u03c9\u03c2, \u03b7 \u03ba\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03b1\u03c0\u03cc\u03b4\u03b5\u03b9\u03be\u03b7 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03b9\u03c4\u03b9\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03c4\u03c9\u03bd \u03c6\u03b1\u03b9\u03bd\u03bf\u03bc\u03ad\u03bd\u03c9\u03bd \u03c4\u03b7\u03c2 \u03c5\u03c0\u03b5\u03c1\u03ba\u03bf\u03c1\u03c4\u03b9\u03b6\u03bf\u03bb\u03b1\u03b9\u03bc\u03af\u03b1\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03c0\u03bb\u03ae\u03c1\u03b7\u03c2 \u03b4\u03b9\u03b1\u03ba\u03bf\u03c0\u03ae \u03c4\u03b7\u03c2 \u0391\u0391 \u03ba\u03b1\u03b9 \u03b7 \u03c3\u03b5 \u03ac\u03bb\u03bb\u03bf\u03c4\u03b5 \u03ac\u03bb\u03bb\u03bf \u03c7\u03c1\u03cc\u03bd\u03bf \u03c5\u03c0\u03bf\u03c7\u03ce\u03c1\u03b7\u03c3\u03b7 \u03cc\u03bb\u03c9\u03bd \u03c4\u03c9\u03bd \u03b5\u03c5\u03c1\u03b7\u03bc\u03ac\u03c4\u03c9\u03bd \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b4\u03c1\u03cc\u03bc\u03bf\u03c5.<\/p>\n
3. \u0391\u03b9\u03b8\u03c5\u03bb\u03b9\u03ba\u03ae \u03b1\u03bb\u03ba\u03bf\u03cc\u03bb\u03b7 \u03ba\u03b1\u03b9 \u03c5\u03c0\u03bf\u03b8\u03b1\u03bb\u03b1\u03bc\u03bf-\u03c5\u03c0\u03bf\u03c6\u03c5\u03c3\u03b9\u03bf-\u03b3\u03bf\u03bd\u03b1\u03b4\u03b9\u03ba\u03cc\u03c2 \u03ac\u03be\u03bf\u03bd\u03b1\u03c2 (\u03a5\u03a5\u0393)<\/b><\/h4>\n
\u0397 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b7 \u03ba\u03b1\u03c4\u03b1\u03bd\u03ac\u03bb\u03c9\u03c3\u03b7 \u0391\u0391 \u03ba\u03b1\u03b9 \u03bf \u03b1\u03bb\u03ba\u03bf\u03bf\u03bb\u03b9\u03c3\u03bc\u03cc\u03c2 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03bf\u03cd\u03bd \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ad\u03c2 \u03c4\u03b7\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2 \u03c4\u03bf\u03c5 \u03b1\u03bd\u03b1\u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03b9\u03ba\u03bf\u03cd \u03c3\u03c5\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b1 \u03b4\u03cd\u03bf \u03c6\u03cd\u03bb\u03b1.\u0395\u03c7\u03b5\u03b9 \u03b4\u03b5\u03b9\u03c7\u03b8\u03b5\u03af \u03cc\u03c4\u03b9 \u03b1\u03c5\u03c4\u03ae \u03b7 \u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03c0\u03c1\u03bf\u03c3\u03b2\u03ac\u03bb\u03bb\u03b5\u03b9 \u03ba\u03b1\u03b9 \u03c4\u03bf\u03c5\u03c2 3 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2 \u03c4\u03bf\u03c5 \u03ac\u03be\u03bf\u03bd\u03b1 \u03a5\u03a5\u0393 \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03b7\u03bd \u03c0\u03c1\u03cc\u03ba\u03bb\u03b7\u03c3\u03b7 \u03c5\u03c0\u03bf\u03b3\u03bf\u03bd\u03b9\u03bc\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2, \u03b1\u03c4\u03c1\u03bf\u03c6\u03af\u03b1\u03c2 \u03c4\u03c9\u03bd \u03b3\u03bf\u03bd\u03ac\u03b4\u03c9\u03bd \u03ba\u03b1\u03b9 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 libido. \u03a3\u03b5 \u03b1\u03c5\u03c4\u03ad\u03c2 \u03c4\u03b9\u03c2 \u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c4\u03c9\u03bd \u03c3\u03c4\u03b5\u03c1\u03bf\u03b5\u03b9\u03b4\u03ce\u03bd \u03c4\u03bf\u03c5 \u03c6\u03cd\u03bb\u03bf\u03c5 \u03b8\u03b1 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03c0\u03c1\u03bf\u03c3\u03b8\u03ad\u03c3\u03bf\u03c5\u03bc\u03b5 \u03ba\u03b1\u03b9 \u03c4\u03b9\u03c2 \u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c0\u03bf\u03c5 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c3\u03c4\u03bf \u03ba\u03b1\u03c1\u03b4\u03b9\u03bf-\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03cc \u03c3\u03cd\u03c3\u03c4\u03b7\u03bc\u03b1, \u03c3\u03c4\u03b7\u03bd \u03c5\u03b3\u03b5\u03af\u03b1 \u03c4\u03c9\u03bd \u03bf\u03c3\u03c4\u03ce\u03bd, \u03c3\u03c4\u03b7 \u03c3\u03cd\u03c3\u03c4\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c3\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03c0\u03bf\u03bb\u03bb\u03ad\u03c2 \u03b3\u03bd\u03c9\u03c3\u03b9\u03b1\u03ba\u03ad\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b5\u03c2.<\/p>\n
\u0397 \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c4\u03b7\u03c2 \u0391\u0391 \u03c3\u03c4\u03bf \u03ac\u03c1\u03c1\u03b5\u03bd \u03b1\u03bd\u03b1\u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03b9\u03ba\u03cc \u03c3\u03cd\u03c3\u03c4\u03b7\u03bc\u03b1.<\/i>\u0395\u03ba\u03c4\u03b5\u03c4\u03b1\u03bc\u03ad\u03bd\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c3\u03b5 \u03c0\u03b5\u03b9\u03c1\u03b1\u03bc\u03b1\u03c4\u03cc\u03b6\u03c9\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b4\u03b5\u03af\u03be\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03b7 \u0391\u0391 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03ac\u03c3\u03b5\u03b9 \u03c4\u03b7 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03c4\u03bf\u03c5 \u03ac\u03be\u03bf\u03bd\u03b1 \u03a5\u03a5\u0393 \u03ac\u03bc\u03b5\u03c3\u03b1 \u03ba\u03b1\u03b9 \u03ad\u03bc\u03bc\u03b5\u03c3\u03b1 \u03bc\u03ad\u03c3\u03c9 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03ac\u03be\u03bf\u03bd\u03b1 \u03a5\u03a5\u0395 (13,14, \u0395\u03b9\u03ba\u03cc\u03bd\u03b1 1).<\/p>\n
\n
![\"18-10-image1\"](\"https:\/\/e-endocrinology.gr\/wp-content\/uploads\/2015\/02\/18-10-image1.jpg\")
<\/p>\n
\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 1<\/strong><\/em>. \u0395\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03b9\u03b8\u03c5\u03bb\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bb\u03ba\u03bf\u03cc\u03bb\u03b7\u03c2 \u03c3\u03c4\u03bf\u03bd \u03ac\u03be\u03bf\u03bd\u03b1 \u03c5\u03c0\u03bf\u03b8\u03ac\u03bb\u03b1\u03bc\u03bf\u03c2-\u03c5\u03c0\u03cc\u03c6\u03c5\u03c3\u03b7-\u03b3\u03bf\u03bd\u03ac\u03b4\u03b5\u03c2<\/p>\n
\n\u039f\u03b9 \u03ac\u03bc\u03b5\u03c3\u03b5\u03c2 \u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9:<\/p>\n
\n- \u03a3\u03c4\u03bf\u03c5\u03c2 \u03c5\u03c0\u03bf\u03b8\u03b1\u03bb\u03b1\u03bc\u03b9\u03ba\u03bf\u03cd\u03c2 \u03bd\u03b5\u03c5\u03c1\u03ce\u03bd\u03b5\u03c2 \u03c4\u03b7\u03c2 LHRH<\/li>\n
- \u0391\u03bc\u03b5\u03c3\u03b7 \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c3\u03c4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 Leydig \u03cc\u03c4\u03b1\u03bd \u03b7 \u0391\u0391 \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03b5\u03af \u03c3\u03c4\u03bf \u03b1\u03af\u03bc\u03b1.<\/li>\n
- \u03a3\u03b5 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ad\u03c2 \u03c4\u03bf\u03c5 \u039a\u039d\u03a3 \u03c0\u03bf\u03c5 \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5\u03bd \u03c4\u03bf \u03c3\u03c4\u03c1\u03b5\u03c2 \u03cc\u03c0\u03c9\u03c2 \u03b7 CRH \u03ba\u03b1\u03b9 \u03bf\u03b9 \u03ba\u03b1\u03c4\u03b5\u03c7\u03bf\u03bb\u03b1\u03bc\u03af\u03bd\u03b5\u03c2.<\/li>\n<\/ul>\n
\u039f \u03b2\u03b1\u03b8\u03bc\u03cc\u03c2 \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03ba\u03b1\u03b8\u03b5\u03bd\u03cc\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5\u03c2 \u03c0\u03b1\u03c1\u03b1\u03c0\u03ac\u03bd\u03c9 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03cd\u03c2 \u03b5\u03be\u03b1\u03c1\u03c4\u03ac\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03b7\u03c2 \u0391\u0391 \u03ba\u03b1\u03b9 \u03c4\u03b7 \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03c4\u03c9\u03bd \u03b5\u03c0\u03b9\u03c0\u03ad\u03b4\u03c9\u03bd \u03b1\u03c5\u03c4\u03ce\u03bd \u03c3\u03c4\u03b7\u03bd \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03af\u03b1. \u0391\u03b4\u03c1\u03ac, \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bc\u03b5 \u03bd\u03b1 \u03c0\u03bf\u03cd\u03bc\u03b5 \u03cc\u03c4\u03b9 \u03bf\u03be\u03b5\u03af\u03b1 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u0391\u0391 \u03c3\u03b5 \u03b4\u03cc\u03c3\u03b7 \u03ad\u03c9\u03c2 1,5 \u03b3\u03c1.\/\u03ba\u03bb \u03a3\u0392 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03b7\u03c2 \u03c4\u03b5\u03c3\u03c4\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7\u03c2, \u03b5\u03bd\u03ce \u03bf\u03b9 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b5\u03c2 \u03b4\u03cc\u03c3\u03b5\u03b9\u03c2 \u03c4\u03b7 \u03bc\u03b5\u03b9\u03ce\u03bd\u03bf\u03c5\u03bd.<\/p>\n
\u03a3\u03c4\u03bf\u03bd \u03ad\u03c6\u03b7\u03b2\u03bf, \u03b1\u03bd \u03ba\u03b1\u03b9 \u03bf\u03b9 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c3\u03c4\u03b7\u03bd \u03b7\u03bb\u03b9\u03ba\u03af\u03b1 \u03b1\u03c5\u03c4\u03ae \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03bf\u03bb\u03cd \u03c0\u03b5\u03c1\u03b9\u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03c1\u03ba\u03b5\u03c4\u03ac \u03c0\u03b1\u03bb\u03b9\u03ad\u03c2, \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03b7 \u0391\u0391 \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03c9\u03bd FSH, LH \u03ba\u03b1\u03b9 \u03c4\u03b5\u03c3\u03c4\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7\u03c2 (15).<\/p>\n
\u03a3\u03c4\u03bf\u03c5\u03c2 \u03b1\u03bb\u03ba\u03bf\u03bf\u03bb\u03b9\u03ba\u03bf\u03cd\u03c2 \u03ac\u03bd\u03b4\u03c1\u03b5\u03c2 \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03b5\u03c5\u03c1\u03ae\u03bc\u03b1\u03c4\u03b1 \u03c0\u03c1\u03c9\u03c4\u03bf\u03c0\u03b1\u03b8\u03bf\u03cd\u03c2 \u03c5\u03c0\u03bf\u03b3\u03bf\u03bd\u03b1\u03b4\u03b9\u03c3\u03bc\u03bf\u03cd (\u03b1\u03cd\u03be\u03b7\u03c3\u03b7 FSH, LH, \u03bf\u03b9\u03c3\u03c4\u03c1\u03bf\u03b3\u03cc\u03bd\u03c9\u03bd, \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b5\u03c3\u03c4\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7\u03c2) \u03ba\u03b1\u03b9 \u03c5\u03c0\u03bf\u03b3\u03bf\u03bd\u03b9\u03bc\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2, \u03b1\u03ba\u03cc\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03b1\u03bd \u03b1\u03ba\u03cc\u03bc\u03b1 \u03b4\u03b5\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03b7\u03c0\u03b1\u03c4\u03b9\u03ba\u03ae \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 (16).<\/p>\n
\u0391\u03bb\u03ba\u03bf\u03bf\u03bb\u03b9\u03ba\u03bf\u03af \u03ac\u03bd\u03b4\u03c1\u03b5\u03c2 \u03bc\u03b5 \u03ba\u03af\u03c1\u03c1\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03ae\u03c0\u03b1\u03c4\u03bf\u03c2 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03bf\u03b9\u03c3\u03c4\u03c1\u03b1\u03b4\u03b9\u03cc\u03bb\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03bf\u03b9\u03c3\u03c4\u03c1\u03cc\u03bd\u03b7\u03c2 \u03bb\u03cc\u03b3\u03c9 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03cc\u03c4\u03b7\u03c4\u03bf\u03c2 \u03c4\u03b7\u03c2 \u03b1\u03c1\u03c9\u03bc\u03b1\u03c4\u03ac\u03c3\u03b7\u03c2 (17). \u03a3\u03c4\u03b7\u03bd \u03c0\u03c1\u03cc\u03ba\u03bb\u03b7\u03c3\u03b7 \u03c5\u03c0\u03bf\u03b3\u03bf\u03bd\u03b1\u03b4\u03b9\u03c3\u03bc\u03bf\u03cd \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03ad\u03c7\u03b5\u03b9 \u03ba\u03b1\u03b9 \u03b7 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b2\u03b9\u03bf\u03b4\u03b9\u03b1\u03b8\u03b5\u03c3\u03b9\u03bc\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c4\u03bf\u03c5 IGF-1 \u03c0\u03bf\u03cd \u03cc\u03c0\u03c9\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b3\u03bd\u03c9\u03c3\u03c4\u03cc \u03b4\u03b9\u03b5\u03b3\u03b5\u03af\u03c1\u03b5\u03b9 \u03c4\u03b7 \u03c3\u03cd\u03bd\u03b8\u03b5\u03c3\u03b7 \u03c4\u03b5\u03c3\u03c4\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7\u03c2 \u03ba\u03b1\u03b8\u03ce\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b7 \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7 (18, 19).<\/p>\n
\u03a0\u03ac\u03bd\u03c4\u03c9\u03c2, \u03c3\u03b5 \u03c0\u03bf\u03bb\u03cd \u03c0\u03c1\u03cc\u03c3\u03c6\u03b1\u03c4\u03b7 \u03c0\u03bf\u03bb\u03c5\u03ba\u03b5\u03bd\u03c4\u03c1\u03b9\u03ba\u03ae \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03c3\u03c4\u03b9\u03c2 \u0397\u03a0\u0391 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u0395\u03c5\u03c1\u03ce\u03c0\u03b7 \u03c3\u03b5 8344 \u03c5\u03b3\u03b9\u03b5\u03af\u03c2 \u03ba\u03b1\u03b9 \u03b3\u03cc\u03bd\u03b9\u03bc\u03bf\u03c5\u03c2 \u03ac\u03bd\u03b4\u03c1\u03b5\u03c2, \u03b2\u03c1\u03ad\u03b8\u03b7\u03ba\u03b5 \u03cc\u03c4\u03b9 \u03b7 \u03ba\u03b1\u03c4\u03b1\u03bd\u03ac\u03bb\u03c9\u03c3\u03b7 \u03b1\u03ba\u03cc\u03bc\u03b1 \u03ba\u03b1\u03b9 >20 \u03bc\u03bf\u03bd\u03ac\u03b4\u03c9\u03bd \u0391\u0391\/\u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b1, \u03cc\u03c7\u03b9 \u03bc\u03cc\u03bd\u03bf \u03b4\u03b5\u03bd \u03b5\u03c0\u03b7\u03c1\u03ad\u03b1\u03b6\u03b5 \u03c4\u03b7\u03bd \u03c0\u03bf\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03bf\u03c5 \u03c3\u03c0\u03ad\u03c1\u03bc\u03b1\u03c4\u03bf\u03c2, \u03b1\u03bb\u03bb\u03ac \u03bf\u03b9 \u03b2\u03b1\u03c1\u03b5\u03af\u03c2 \u03c0\u03cc\u03c4\u03b5\u03c2 \u03b5\u03af\u03c7\u03b1\u03bd \u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03b5\u03bb\u03b5\u03cd\u03b8\u03b5\u03c1\u03b7\u03c2 \u03c4\u03b5\u03c3\u03c4\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5\u03c2 \u03bc\u03ad\u03c4\u03c1\u03b9\u03bf\u03c5\u03c2 \u03c0\u03cc\u03c4\u03b5\u03c2 (1-10 \u03bc\u03bf\u03bd\u03ac\u03b4\u03b5\u03c2\/\u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b1) (20). \u039d\u03b1 \u03c3\u03b7\u03bc\u03b5\u03b9\u03c9\u03b8\u03b5\u03af \u03b2\u03ad\u03b2\u03b1\u03b9\u03b1 \u03cc\u03c4\u03b9 \u03b7 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03bf\u03c7\u03ae \u03ae\u03c4\u03b1\u03bd \u03bc\u03cc\u03bb\u03b9\u03c2 20-30% \u03c3\u03c4\u03b1 \u03b4\u03b9\u03ac\u03c6\u03bf\u03c1\u03b1 \u03ba\u03ad\u03bd\u03c4\u03c1\u03b1 \u03ba\u03b1\u03b9 \u03b7 \u03ba\u03b1\u03c4\u03b1\u03bd\u03ac\u03bb\u03c9\u03c3\u03b7 \u03b1\u03bb\u03ba\u03bf\u03cc\u03bb \u03bc\u03ad\u03c3\u03c9 \u03b5\u03c1\u03c9\u03c4\u03b7\u03bc\u03b1\u03c4\u03bf\u03bb\u03bf\u03b3\u03af\u03bf\u03c5 \u03b1\u03c6\u03bf\u03c1\u03bf\u03cd\u03c3\u03b5 \u03bc\u03cc\u03bd\u03bf \u03c4\u03b7\u03bd \u03c4\u03b5\u03bb\u03b5\u03c5\u03c4\u03b1\u03af\u03b1 \u03c0\u03c1\u03cc \u03c4\u03bf\u03c5 \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b1.<\/p>\n
\u0397 \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c4\u03b7\u03c2 \u0391\u0391 \u03c3\u03c4\u03bf \u03b8\u03ae\u03bb\u03c5 \u03b1\u03bd\u03b1\u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03b9\u03ba\u03cc \u03c3\u03cd\u03c3\u03c4\u03b7\u03bc\u03b1.<\/i>\u03a3\u03c4\u03b9\u03c2 \u03c0\u03c1\u03bf\u03b5\u03bc\u03bc\u03b7\u03bd\u03bf\u03c0\u03b1\u03c5\u03c3\u03b9\u03b1\u03ba\u03ad\u03c2 \u03b3\u03c5\u03bd\u03b1\u03af\u03ba\u03b5\u03c2, \u03b1\u03ba\u03cc\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03b7 \u03bc\u03ad\u03c4\u03c1\u03b9\u03b1 \u03ba\u03b1\u03c4\u03b1\u03bd\u03ac\u03bb\u03c9\u03c3\u03b7 \u0391\u0391 \u03ad\u03c7\u03b5\u03b9 \u03b5\u03bd\u03bf\u03c7\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03b5\u03af \u03b3\u03b9\u03b1 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ad\u03c2 \u03c4\u03b7\u03c2 \u03c0\u03b5\u03c1\u03b9\u03cc\u03b4\u03bf\u03c5, \u03b1\u03bd\u03c9\u03bf\u03c1\u03c1\u03b7\u03be\u03af\u03b1, \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03b1\u03c0\u03bf\u03b2\u03bf\u03bb\u03ce\u03bd \u03ba\u03b1\u03b9 \u03c0\u03c1\u03ce\u03b9\u03bc\u03bc\u03b7 \u03b5\u03bc\u03bc\u03b7\u03bd\u03cc\u03c0\u03b1\u03c5\u03c3\u03b7 (21).<\/p>\n
\u03a3\u03c4\u03b9\u03c2 \u03bc\u03b5\u03c4\u03b5\u03bc\u03bc\u03b7\u03bd\u03bf\u03c0\u03b1\u03c5\u03c3\u03b9\u03b1\u03ba\u03ad\u03c2 \u03b3\u03c5\u03bd\u03b1\u03af\u03ba\u03b5\u03c2 \u03c3\u03b5 \u03bf\u03c1\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03c5\u03c0\u03bf\u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7, \u03b7 \u0391\u0391 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03b7\u03c2 \u03bf\u03b9\u03c3\u03c4\u03c1\u03b1\u03b4\u03b9\u03cc\u03bb\u03b7\u03c2 \u03bb\u03cc\u03b3\u03c9 \u03bc\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7\u03c2 \u03bc\u03b5\u03c4\u03b1\u03c4\u03c1\u03bf\u03c0\u03ae\u03c2 \u03b1\u03c5\u03c4\u03ae\u03c2 \u03c3\u03b5 \u03bf\u03b9\u03c3\u03c4\u03c1\u03cc\u03bd\u03b7. \u0391\u03bd\u03ac\u03bb\u03bf\u03b3\u03bf \u03b5\u03cd\u03c1\u03b7\u03bc\u03b1 \u03b4\u03b5\u03bd \u03c5\u03c0\u03ae\u03c1\u03be\u03b5 \u03c3\u03b5 \u03b3\u03c5\u03bd\u03b1\u03af\u03ba\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03b4\u03b5\u03bd \u03b5\u03bb\u03ac\u03bc\u03b2\u03b1\u03bd\u03b1\u03bd \u03bf\u03b9\u03c3\u03c4\u03c1\u03bf\u03b3\u03cc\u03bd\u03b1 (22), \u03b1\u03bd \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03ac\u03bb\u03bb\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03ba\u03b1\u03c4\u03b1\u03b4\u03b5\u03b9\u03ba\u03bd\u03cd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03b1\u03c5\u03c4\u03ae\u03c2.<\/p>\n
4. \u0391\u03b9\u03b8\u03c5\u03bb\u03b9\u03ba\u03ae \u03b1\u03bb\u03ba\u03bf\u03cc\u03bb\u03b7, \u03c0\u03b1\u03b3\u03ba\u03c1\u03b5\u03b1\u03c4\u03b9\u03ba\u03ae \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03ba\u03b1\u03b9 \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7\u03c2<\/b><\/h4>\n
\u0397 \u03c3\u03c7\u03ad\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c0\u03bf\u03c3\u03bf\u03c4\u03b9\u03ba\u03ae\u03c2 \u03ba\u03b1\u03c4\u03b1\u03bd\u03ac\u03bb\u03c9\u03c3\u03b7\u03c2 \u0391\u0391 \u03bc\u03b5 \u03c4\u03bf \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7 \u03ad\u03c7\u03b5\u03b9 \u03c3\u03c7\u03ae\u03bc\u03b1 U. \u0394\u03b7\u03bb\u03b1\u03b4\u03ae \u03ae \u03bc\u03b9\u03ba\u03c1\u03ae \u03ae \u03bc\u03ad\u03c4\u03c1\u03b9\u03b1 \u03ba\u03b1\u03c4\u03b1\u03bd\u03ac\u03bb\u03c9\u03c3\u03b7 \u0391\u0391 \u03c3\u03c5\u03bd\u03bf\u03b4\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03ba\u03b1\u03c4\u03ac 30% \u03c4\u03bf\u03c5 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7\u03c2 \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7, \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03bb\u03cc\u03b3\u03c9 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03af\u03b1\u03c2 \u03c4\u03c9\u03bd \u03c0\u03b5\u03c1\u03b9\u03c6\u03b5\u03c1\u03b9\u03ba\u03ce\u03bd \u03b9\u03c3\u03c4\u03ce\u03bd \u03c3\u03c4\u03b7 \u03b4\u03c1\u03ac\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b9\u03bd\u03c3\u03bf\u03c5\u03bb\u03af\u03bd\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03b1\u03bd\u03b1\u03c3\u03c4\u03b1\u03bb\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b4\u03c1\u03ac\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u0391\u0391 \u03c3\u03c4\u03b7 \u03bb\u03b9\u03c0\u03cc\u03bb\u03c5\u03c3\u03b7, \u03c7\u03c9\u03c1\u03af\u03c2 \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b2\u03ad\u03b2\u03b1\u03b9\u03bf \u03b1\u03bd \u03b7 \u0391\u0391 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b5\u03ba\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae \u03b4\u03c1\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03bf\u03c5 \u03c0\u03b1\u03b3\u03ba\u03c1\u03ad\u03b1\u03c4\u03bf\u03c2 (23). \u0395\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd, \u03b1\u03c5\u03c4\u03ad\u03c2 \u03bf\u03b9 \u03c0\u03bf\u03c3\u03cc\u03c4\u03b7\u03c4\u03b5\u03c2 \u0391\u0391 \u03bc\u03b5\u03b9\u03ce\u03bd\u03bf\u03c5\u03bd \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03c4\u03b7 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03ba\u03bf\u03cd \u03c3\u03c5\u03bd\u03b4\u03c1\u03cc\u03bc\u03bf\u03c5, \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c3\u03b5 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03c4\u03b7\u03c2 \u03bb\u03b5\u03c5\u03ba\u03ae\u03c2 \u03c6\u03c5\u03bb\u03ae\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03b1\u03c5\u03c4\u03bf\u03cd\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03af\u03bd\u03bf\u03c5\u03bd \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b5\u03c1\u03b1 \u03ba\u03c1\u03b1\u03c3\u03af \u03ae \u03bc\u03c0\u03af\u03c1\u03b1 (24).<\/p>\n
\u0391\u03bd\u03c4\u03af\u03b8\u03b5\u03c4\u03b1, \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7\u03c22 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b1\u03bb\u03ba\u03bf\u03bf\u03bb\u03b9\u03ba\u03bf\u03cd\u03c2 (25). \u0391\u03c5\u03c4\u03cc \u03bf\u03c6\u03b5\u03af\u03bb\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03c0\u03c1\u03cc\u03ba\u03bb\u03b7\u03c3\u03b7 \u03b9\u03bd\u03c3\u03bf\u03c5\u03bb\u03b9\u03bd\u03bf\u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03b1\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2 \u03c3\u03c4\u03b1 \u03b2-\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c4\u03bf\u03c5 \u03c0\u03b1\u03b3\u03ba\u03c1\u03ad\u03b1\u03c4\u03bf\u03c2.<\/p>\n
\u0391\u03bd\u03b1\u03bb\u03c5\u03c4\u03b9\u03ba\u03cc\u03c4\u03b5\u03c1\u03b1, \u03bf\u03b9 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03af \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u0391\u0391 \u03c6\u03b1\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 2.<\/p>\n
\n
\n<\/b><\/p>\n
![\"18-10-image2\"](\"https:\/\/e-endocrinology.gr\/wp-content\/uploads\/2015\/02\/18-10-image2.jpg\")
<\/p>\n
\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 2<\/strong><\/em>. \u039c\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03af \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03b1\u03b9\u03b8\u03c5\u03bb\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bb\u03ba\u03bf\u03cc\u03bb\u03b7\u03c2<\/p>\n
\n5. \u0391\u03b9\u03b8\u03c5\u03bb\u03b9\u03ba\u03ae \u03b1\u03bb\u03ba\u03bf\u03cc\u03bb\u03b7 \u03ba\u03b1\u03b9 \u03ba\u03b9\u03c1\u03ba\u03b1\u03b4\u03b9\u03ba\u03bf\u03af \u03c1\u03c5\u03b8\u03bc\u03bf\u03af<\/b><\/h4>\n
\u039f \u03ba\u03b5\u03bd\u03c4\u03c1\u03b9\u03ba\u03cc\u03c2 \u03b2\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03cc\u03c4\u03b7\u03c2 \u03c4\u03c9\u03bd \u03ba\u03b9\u03c1\u03ba\u03b1\u03b4\u03b9\u03ba\u03ce\u03bd \u03c1\u03c5\u03b8\u03bc\u03ce\u03bd \u03b2\u03c1\u03af\u03c3\u03ba\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf\u03bd \u03c5\u03c0\u03b5\u03c1\u03c7\u03b9\u03b1\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc \u03c0\u03c5\u03c1\u03ae\u03bd\u03b1 \u03c4\u03bf\u03c5 \u03c0\u03c1\u03cc\u03c3\u03b8\u03b9\u03bf\u03c5 \u03c5\u03c0\u03bf\u03b8\u03ac\u03bb\u03b1\u03bc\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03c3\u03c5\u03b3\u03c7\u03c1\u03bf\u03bd\u03af\u03b6\u03b5\u03b9 \u03cc\u03bb\u03bf\u03c5\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03bf\u03cd\u03c2 \u03c1\u03c5\u03b8\u03bc\u03bf\u03cd\u03c2 \u03c3\u03b5 \u03b1\u03c0\u03ac\u03bd\u03c4\u03b7\u03c3\u03b7 \u03c3\u03c4\u03b9\u03c2 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ad\u03c2 \u03c4\u03bf\u03c5 \u03b5\u03be\u03c9\u03c4\u03b5\u03c1\u03b9\u03ba\u03bf\u03cd \u03c0\u03b5\u03c1\u03b9\u03b2\u03ac\u03bb\u03bb\u03bf\u03bd\u03c4\u03bf\u03c2 \u03b2\u03b5\u03bb\u03c4\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7\u03bd \u03c0\u03c1\u03bf\u03c3\u03b1\u03c1\u03bc\u03bf\u03b3\u03ae \u03c4\u03bf\u03c5 \u03bf\u03c1\u03b3\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03cd.<\/p>\n
\u039f\u03b9 \u03ba\u03b9\u03c1\u03ba\u03b1\u03b4\u03b9\u03ba\u03ad\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b5\u03c2 \u03c4\u03bf\u03c5 \u03ba\u03b5\u03bd\u03c4\u03c1\u03b9\u03ba\u03bf\u03cd \u03b2\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03cc\u03c4\u03b7, \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03ac\u03bb\u03bb\u03c9\u03bd \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ce\u03bd \u03c4\u03bf\u03c5 \u039a\u039d\u03a3 \u03ba\u03b1\u03b9 \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c4\u03b7\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c6\u03ad\u03c1\u03b5\u03b9\u03b1\u03c2, \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c0\u03bb\u03b7\u03b8\u03ce\u03c1\u03b1 \u03b5\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03c9\u03bd (Per1, Per2, Per3, Clock, Bmal1, Cry1, Cry2) (26, 27).<\/p>\n
\u03a0\u03bf\u03bb\u03c5\u03ac\u03c1\u03b9\u03b8\u03bc\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c3\u03b5 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03bf\u03c5\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03b5\u03b9\u03c1\u03b1\u03bc\u03b1\u03c4\u03cc\u03b6\u03c9\u03b1 \u03ad\u03b4\u03b5\u03b9\u03be\u03b1\u03bd \u03cc\u03c4\u03b9 \u03b7 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03ad\u03ba\u03b8\u03b5\u03c3\u03b7 \u03c3\u03c4\u03bf \u03b1\u03bb\u03ba\u03bf\u03cc\u03bb \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ad\u03c2 \u03c3\u03c4\u03b7 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03c9\u03bd \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03c9\u03bd \u03c4\u03bf\u03c5 \u03c1\u03bf\u03bb\u03bf\u03b3\u03b9\u03bf\u03cd, \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03bf\u03bd \u03b1\u03c0\u03bf\u03c3\u03c5\u03bd\u03c4\u03bf\u03bd\u03b9\u03c3\u03bc\u03cc \u03c4\u03c9\u03bd \u03ba\u03b9\u03c1\u03ba\u03b1\u03b4\u03b9\u03ba\u03ce\u03bd \u03c1\u03c5\u03b8\u03bc\u03ce\u03bd \u03cc\u03c0\u03c9\u03c2 \u03c4\u03bf\u03bd \u03cd\u03c0\u03bd\u03bf, \u03c4\u03b7 \u03b8\u03b5\u03c1\u03bc\u03bf\u03ba\u03c1\u03b1\u03c3\u03af\u03b1 \u03c4\u03bf\u03c5 \u03c3\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2, \u03c4\u03b7\u03bd \u03b1\u03c1\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae \u03c0\u03af\u03b5\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c0\u03bf\u03b9\u03ba\u03af\u03bb\u03b5\u03c2 \u03bf\u03c1\u03bc\u03bf\u03bd\u03b9\u03ba\u03ad\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b5\u03c2, \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03cc\u03c3\u03bf\u03bd \u03b1\u03c6\u03bf\u03c1\u03ac \u03c4\u03b7\u03bd \u03b5\u03c0\u03b5\u03b9\u03c3\u03bf\u03b4\u03b9\u03b1\u03ba\u03ae \u03c4\u03bf\u03c5\u03c2 \u03ad\u03ba\u03ba\u03c1\u03b9\u03c3\u03b7. \u0391\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03b1\u03bd\u03c4\u03b9\u03c3\u03c4\u03c1\u03cc\u03c6\u03c9\u03c2, \u03c4\u03b1 \u03af\u03b4\u03b9\u03b1 \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 \u03b5\u03c5\u03bd\u03bf\u03bf\u03cd\u03bd \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03ba\u03b1\u03c4\u03ac\u03c7\u03c1\u03b7\u03c3\u03b7 \u0391\u0391 \u03ba\u03b1\u03b9 \u03b3\u03b5\u03bd\u03b9\u03ba\u03ce\u03c2 \u03c4\u03b9\u03c2 \u03b5\u03be\u03b1\u03c1\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2 \u03c3\u03b5 \u03b4\u03b9\u03ac\u03c6\u03bf\u03c1\u03b5\u03c2 \u03bf\u03c5\u03c3\u03af\u03b5\u03c2 (28).<\/p>\n
\u03a3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c4\u03c9\u03bd \u03ba\u03b9\u03c1\u03ba\u03b1\u03b4\u03b9\u03ba\u03ce\u03bd \u03c1\u03c5\u03b8\u03bc\u03ce\u03bd \u03c3\u03c4\u03bf \u03c3\u03c4\u03c1\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03bf \u03b1\u03bd\u03bf\u03c3\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03cc \u03c3\u03cd\u03c3\u03c4\u03b7\u03bc\u03b1 \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03b7\u03bd \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7\u03c2 \u03ba\u03b1\u03ba\u03bf\u03ae\u03b8\u03c9\u03bd \u03bd\u03cc\u03c3\u03c9\u03bd.<\/p>\n
6. \u039f\u03b9 \u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c4\u03b7\u03c2 \u03b1\u03b9\u03b8\u03c5\u03bb\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bb\u03ba\u03bf\u03cc\u03bb\u03b7\u03c2 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03bb\u03bf\u03b9\u03c0\u03bf\u03cd\u03c2 \u03b5\u03bd\u03b4\u03bf\u03ba\u03c1\u03b9\u03bd\u03b5\u03af\u03c2 \u03b1\u03b4\u03ad\u03bd\u03b5\u03c2 <\/b><\/h4>\n
\u0398\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1.<\/i>\u03a3\u03b5 \u03b1\u03bb\u03ba\u03bf\u03bf\u03bb\u03b9\u03ba\u03bf\u03cd\u03c2, \u03b1\u03bc\u03ad\u03c3\u03c9\u03c2 \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7 \u03b4\u03b9\u03b1\u03ba\u03bf\u03c0\u03ae \u03c4\u03b7\u03c2 \u0391\u0391, \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b5\u03c0\u03b9\u03c0\u03ad\u03b4\u03c9\u03bd \u03a44 \u03ba\u03b1\u03b9 \u03a43 \u03c3\u03c4\u03bf \u03b1\u03af\u03bc\u03b1, \u03c4\u03b1\u03c5\u03c4\u03cc\u03c7\u03c1\u03bf\u03bd\u03b1 \u03bc\u03b5 \u03c4\u03c5\u03c6\u03bb\u03ae \u03b1\u03c0\u03ac\u03bd\u03c4\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 TSH \u03c3\u03c4\u03bf TRH (29, 30).\u038c\u03bb\u03b1 \u03c4\u03b1 \u03c0\u03c1\u03bf\u03b7\u03b3\u03bf\u03cd\u03bc\u03b5\u03bd\u03b1 \u03b5\u03c5\u03c1\u03ae\u03bc\u03b1\u03c4\u03b1 \u03c5\u03c0\u03bf\u03c7\u03c9\u03c1\u03bf\u03cd\u03bd \u03c0\u03bb\u03ae\u03c1\u03c9\u03c2 \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u03bc\u03b1\u03ba\u03c1\u03bf\u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03b1\u03c0\u03bf\u03c7\u03ae \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u0391\u0391, \u03b1\u03bb\u03bb\u03ac \u03b5\u03c0\u03b1\u03bd\u03ad\u03c1\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b5\u03c0\u03af \u03c5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03ae\u03c2 \u03c4\u03bf\u03c5 \u03b1\u03bb\u03ba\u03bf\u03bf\u03bb\u03b9\u03c3\u03bc\u03bf\u03cd.<\/p>\n
\u03a0\u03c1\u03bf\u03c4\u03b5\u03b9\u03bd\u03cc\u03bc\u03b5\u03bd\u03bf\u03b9 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03af \u03b3\u03b9\u03b1 \u03c4\u03b9\u03c2 \u03c0\u03b1\u03c1\u03b1\u03c0\u03ac\u03bd\u03c9 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ad\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9:<\/p>\n
\n- \u0394\u03c5\u03c3\u03bc\u03b5\u03bd\u03ae\u03c2 \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c4\u03b7\u03c2 \u0391\u0391 \u03b5\u03c0\u03af \u03c4\u03bf\u03c5 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03bf\u03cd\u03c2 \u03ba\u03b1\u03b9 \u03b5\u03bb\u03bb\u03b9\u03c0\u03ae\u03c2 \u03b1\u03c0\u03ac\u03bd\u03c4\u03b7\u03c3\u03b7 \u03c3\u03c4\u03b7 \u03b4\u03b9\u03b5\u03b3\u03b5\u03c1\u03c4\u03b9\u03ba\u03ae \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c4\u03b7\u03c2 TSH.<\/li>\n
- \u039c\u03b5\u03b9\u03bf\u03bd\u03b5\u03ba\u03c4\u03b9\u03ba\u03ae \u03b1\u03c0\u03ac\u03bd\u03c4\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 TSH \u03c3\u03c4\u03b7 \u03b4\u03b9\u03b5\u03b3\u03b5\u03c1\u03c4\u03b9\u03ba\u03ae \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c4\u03b7\u03c2 TRH, \u03bb\u03cc\u03b3\u03c9 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03af\u03b1\u03c2 \u03c4\u03c9\u03bd \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03c9\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03c9\u03bd \u03c4\u03b7\u03c2 \u03c5\u03c0\u03cc\u03c6\u03c5\u03c3\u03b7\u03c2.<\/li>\n
- \u0395\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c3\u03c4\u03b7 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03c9\u03bd \u03c4\u03cd\u03c0\u03bf\u03c5 1 \u03ba\u03b1\u03b9 2 \u03b4\u03b5\u03ca\u03c9\u03b4\u03b9\u03bd\u03b1\u03c3\u03ce\u03bd<\/li>\n<\/ul>\n
\u0395\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c0\u03c1\u03bf\u03bb\u03b1\u03ba\u03c4\u03af\u03bd\u03b7\u03c2 (PRL).<\/i>\u03a0\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03ac, \u03c4\u03bf \u03c3\u03cd\u03bd\u03bf\u03bb\u03bf \u03c4\u03c9\u03bd \u03bc\u03b5\u03bb\u03b5\u03c4\u03ce\u03bd \u03ba\u03b1\u03c4\u03b1\u03bb\u03ae\u03b3\u03b5\u03b9 \u03c3\u03c4\u03bf \u03c3\u03c5\u03bc\u03c0\u03ad\u03c1\u03b1\u03c3\u03bc\u03b1 \u03cc\u03c4\u03b9 \u03b7 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03ba\u03b1\u03c4\u03b1\u03bd\u03ac\u03bb\u03c9\u03c3\u03b7 \u03bc\u03b5\u03b3\u03ac\u03bb\u03c9\u03bd \u03c0\u03bf\u03c3\u03bf\u03c4\u03ae\u03c4\u03c9\u03bd \u0391\u0391 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af \u03c5\u03c0\u03b5\u03c1\u03c0\u03c1\u03bf\u03bb\u03b1\u03ba\u03c4\u03b9\u03bd\u03b1\u03b9\u03bc\u03af\u03b1 \u03c3\u03c4\u03b9\u03c2 \u03b3\u03c5\u03bd\u03b1\u03af\u03ba\u03b5\u03c2 \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03ac\u03bd\u03b4\u03c1\u03b5\u03c2, \u03b1\u03ba\u03cc\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03c7\u03c9\u03c1\u03af\u03c2 \u03c3\u03c5\u03bd\u03cd\u03c0\u03b1\u03c1\u03be\u03b7 \u03b7\u03c0\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1\u03c2 (31). \u0397 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7\u03c2 PRL \u03c3\u03b5 \u03b5\u03be\u03b1\u03c1\u03c4\u03b7\u03bc\u03ad\u03bd\u03b1 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 60% \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03ac \u03c4\u03b7\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c6\u03c4\u03ac\u03c3\u03bf\u03c5\u03bd \u03b1\u03ba\u03cc\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b1 180 ng\/dl, \u03b1\u03bd \u03ba\u03b1\u03b9 \u03b7 \u03c3\u03c5\u03bd\u03ae\u03b8\u03b7\u03c2 \u03b4\u03b9\u03b1\u03ba\u03cd\u03bc\u03b1\u03bd\u03c3\u03b7 \u03c3\u03c4\u03b9\u03c2 \u03b4\u03b9\u03ac\u03c6\u03bf\u03c1\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03ae\u03c4\u03b1\u03bd 28-84 ng\/dl.\u0391\u03b9\u03c4\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac, \u03b5\u03c5\u03c1\u03ae\u03bc\u03b1\u03c4\u03b1 \u03c3\u03b5 \u03c0\u03b5\u03b9\u03c1\u03b1\u03bc\u03b1\u03c4\u03cc\u03b6\u03c9\u03b1 \u03ad\u03b4\u03b5\u03b9\u03be\u03b1\u03bd \u03cc\u03c4\u03b9 \u03b7 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03ba\u03b1\u03c4\u03b1\u03bd\u03ac\u03bb\u03c9\u03c3\u03b7 \u03bc\u03b5\u03b3\u03ac\u03bb\u03c9\u03bd \u03c0\u03bf\u03c3\u03bf\u03c4\u03ae\u03c4\u03c9\u03bd \u0391\u0391 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af \u03c5\u03c0\u03b5\u03c1\u03c0\u03bb\u03b1\u03c3\u03af\u03b1 \u03c4\u03c9\u03bd \u03bb\u03b1\u03ba\u03c4\u03bf\u03c4\u03c1\u03cc\u03c6\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd, \u03b1\u03ba\u03cc\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03b1\u03b4\u03ad\u03bd\u03c9\u03bc\u03b1 (32).<\/p>\n
\u0395\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03b1\u03c5\u03be\u03b7\u03c4\u03b9\u03ba\u03ae\u03c2 \u03bf\u03c1\u03bc\u03cc\u03bd\u03b7\u03c2 (GH) \u03ba\u03b1\u03b9 IGF-1.<\/i>\u03a0\u03bf\u03bb\u03bb\u03ad\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c3\u03b5 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03bf\u03c5\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03c0\u03b5\u03b9\u03c1\u03b1\u03bc\u03b1\u03c4\u03cc\u03b6\u03c9\u03b1 \u03ad\u03b4\u03b5\u03b9\u03be\u03b1\u03bd \u03cc\u03c4\u03b9 \u03b7 \u03bf\u03be\u03b5\u03af\u03b1 \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03b7 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03ba\u03b1\u03c4\u03b1\u03bd\u03ac\u03bb\u03c9\u03c3\u03b7 \u0391\u0391 \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03b7\u03c2 GH \u03ba\u03b1\u03b9 \u03c4\u03bf\u03c5 IGF-1.\u03a3\u03b5 \u03bc\u03af\u03b1 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03b4\u03b5\u03af\u03c7\u03b8\u03b7\u03ba\u03b5 \u03cc\u03c4\u03b9 \u03bf\u03be\u03b5\u03af\u03b1 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 1,5 \u03b3\u03c1\/\u03ba\u03bb \u03a3\u03a3 \u0391\u0391 \u03bc\u03b5\u03af\u03c9\u03c3\u03b5 \u03c4\u03b9\u03c2 \u03bd\u03c5\u03c7\u03c4\u03b5\u03c1\u03b9\u03bd\u03ad\u03c2 \u03b5\u03ba\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b1\u03b9\u03c7\u03bc\u03ad\u03c2 \u03c4\u03b7\u03c2 GH\u00a0 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03ac\u03bd\u03b4\u03c1\u03b5\u03c2 \u03b1\u03bb\u03bb\u03ac \u03cc\u03c7\u03b9 \u03c3\u03c4\u03b9\u03c2 \u03b3\u03c5\u03bd\u03b1\u03af\u03ba\u03b5\u03c2 (33). \u03a3\u03b5 \u03c0\u03b5\u03b9\u03c1\u03b1\u03bc\u03b1\u03c4\u03cc\u03b6\u03c9\u03b1, \u03bc\u03b1\u03ba\u03c1\u03bf\u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u0391\u0391 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af \u03bc\u03b5\u03b3\u03ac\u03bb\u03b7 \u03ba\u03b1\u03b9 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b5\u03c4\u03b1\u03bc\u03ad\u03bd\u03b7 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 GH (34).\u0391\u03b9\u03c4\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac, \u03c4\u03bf\u03c5\u03bb\u03ac\u03c7\u03b9\u03c3\u03c4\u03bf\u03bd \u03c3\u03c4\u03b1 \u03c4\u03c1\u03c9\u03ba\u03c4\u03b9\u03ba\u03ac, \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03b7 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b5\u03c0\u03b9\u03c0\u03ad\u03b4\u03c9\u03bd \u03c4\u03b7\u03c2 GH \u03bf\u03c6\u03b5\u03af\u03bb\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 GHRH \u03c3\u03c4\u03bf\u03bd \u03c5\u03c0\u03bf\u03b8\u03ac\u03bb\u03b1\u03bc\u03bf (35).\u0395\u03ba\u03c4\u03cc\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03ac\u03bb\u03bb\u03b5\u03c2 \u03b5\u03c0\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2, \u03b7 \u0391\u0391 \u03b5\u03c0\u03b9\u03b4\u03c1\u03ac \u03ac\u03bc\u03b5\u03c3\u03b1 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03b9\u03ba\u03ae \u03c3\u03cd\u03bd\u03b8\u03b5\u03c3\u03b7 \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1\u00a0 \u03c4\u03b7 \u03bc\u03b5\u03b9\u03bf\u03bd\u03b5\u03ba\u03c4\u03b9\u03ba\u03ae \u03bc\u03c5\u03ca\u03ba\u03ae \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7, \u03bc\u03ad\u03c3\u03c9 \u03b5\u03ba\u03bb\u03b5\u03ba\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7\u03c2 \u03c3\u03c4\u03b7 \u03c3\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03cc\u03c4\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 IGF-1 \u03c0\u03c1\u03bf\u03c2 \u03c4\u03b1 \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 \u03c0\u03bf\u03c5 \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03c5\u03c0\u03b5\u03c1\u03c4\u03c1\u03bf\u03c6\u03af\u03b1 \u03c4\u03c9\u03bd \u03c4\u03cd\u03c0\u03bf\u03c5 \u0399\u0399x \u03bc\u03c5\u03ca\u03ba\u03ce\u03bd \u03b9\u03bd\u03ce\u03bd (36).<\/p>\n7. \u03a3\u03c5\u03bc\u03c0\u03b5\u03c1\u03ac\u03c3\u03bc\u03b1\u03c4\u03b1<\/b><\/h4>\n
\u0397 \u03bc\u03b1\u03ba\u03c1\u03bf\u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03ba\u03b1\u03c4\u03b1\u03bd\u03ac\u03bb\u03c9\u03c3\u03b7 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b7\u03c2 \u03c0\u03bf\u03c3\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u0391\u0391 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03ac\u03c3\u03c3\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03ba\u03bf\u03b9\u03bd\u03c9\u03bd\u03af\u03b1 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03bd\u03b5\u03c5\u03c1\u03b9\u03ba\u03bf\u03cd, \u03b5\u03bd\u03b4\u03bf\u03ba\u03c1\u03b9\u03bd\u03b9\u03ba\u03bf\u03cd \u03ba\u03b1\u03b9 \u03b1\u03bd\u03bf\u03c3\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03bf\u03cd \u03c3\u03c5\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2 \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03b7\u03bd \u03c0\u03c1\u03cc\u03ba\u03bb\u03b7\u03c3\u03b7 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ce\u03bd \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ce\u03bd \u03c3\u03b5 \u03c3\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc, \u03c8\u03c5\u03c7\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03c6\u03bf\u03c1\u03b9\u03ba\u03cc \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03bf.<\/p>\n
\u0391\u03bd\u03b1\u03c6\u03bf\u03c1\u03b9\u03ba\u03ac \u03bc\u03b5 \u03c4\u03b9\u03c2 \u03b5\u03bd\u03b4\u03bf\u03ba\u03c1\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ad\u03c2, \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c5\u03c4\u03ad\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf\u03bd \u03ac\u03be\u03bf\u03bd\u03b1 \u03a5\u03a5\u0395, \u03bf\u03b9 \u03bf\u03c0\u03bf\u03af\u03b5\u03c2 \u03b4\u03b5\u03c5\u03c4\u03b5\u03c1\u03bf\u03b3\u03b5\u03bd\u03ce\u03c2 \u03b5\u03c0\u03b9\u03b4\u03c1\u03bf\u03cd\u03bd \u03ba\u03b1\u03b9 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf\u03c5\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5\u03c2 \u03bb\u03bf\u03b9\u03c0\u03bf\u03cd\u03c2 \u03b5\u03bd\u03b4\u03bf\u03ba\u03c1\u03b9\u03bd\u03b9\u03ba\u03bf\u03cd\u03c2 \u03ac\u03be\u03bf\u03bd\u03b5\u03c2.<\/p>\n
\u039f\u03b9 \u03ba\u03cd\u03c1\u03b9\u03b5\u03c2 \u03b5\u03c0\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c4\u03b7\u03c2 \u0391\u0391 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b5\u03bd\u03b4\u03bf\u03ba\u03c1\u03b9\u03bd\u03b5\u03af\u03c2 \u03b1\u03b4\u03ad\u03bd\u03b5\u03c2 \u03c6\u03b1\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf\u03bd \u03c0\u03af\u03bd\u03b1\u03ba\u03b1 1.<\/p>\n
\u03a0\u03af\u03bd\u03b1\u03ba\u03b1\u03c2 1. <\/b>O\u03c1\u03bc\u03bf\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c4\u03b7\u03c2 \u03b1\u03b9\u03b8\u03c5\u03bb\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bb\u03ba\u03bf\u03cc\u03bb\u03b7\u03c2 \u03c3\u03c4\u03bf \u03b5\u03bd\u03b4\u03bf\u03ba\u03c1\u03b9\u03bd\u03b9\u03ba\u03cc \u03c3\u03cd\u03c3\u03c4\u03b7\u03bc\u03b1.<\/p>\n\n\n\n| \u00a0<\/b><\/span><\/td>\n | \u00a0<\/b><\/span><\/td>\n | \n \u039f\u03be\u03b5\u03af\u03b1 \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7<\/b><\/span><\/p>\n<\/td>\n | \n \u03a7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n\n\u0395\u03bd\u03b4\u03bf\u03ba\u03c1\u03b9\u03bd\u03ae\u03c2 \u03b1\u03b4\u03ad\u03bd\u03b1\u03c2<\/strong><\/td>\n\u039f\u03c1\u03bc\u03cc\u03bd\u03b7<\/strong><\/td>\n| \n \u0386\u03bd\u03b4\u03c1\u03b1\u03c2<\/strong><\/p>\n<\/td>\n| \n \u0393\u03c5\u03bd\u03b1\u03af\u03ba\u03b1<\/strong><\/p>\n<\/td>\n| \n \u0386\u03bd\u03b4\u03c1\u03b1\u03c2<\/strong><\/p>\n<\/td>\n| \n \u0393\u03c5\u03bd\u03b1\u03af\u03ba\u03b1<\/strong><\/p>\n<\/td>\n<\/tr>\n\n| \u03a5\u03c0\u03bf\u03b8\u03ac\u03bb\u03b1\u03bc\u03bf\u03c2<\/td>\n | CRH<\/td>\n | \n \u0391<\/p>\n<\/td>\n | \n \u0391<\/p>\n<\/td>\n | \n \u039d<\/p>\n<\/td>\n | \n \u039d<\/p>\n<\/td>\n<\/tr>\n | \n| <\/td>\n | LHRH<\/td>\n | \n \u0391<\/p>\n<\/td>\n | \n \u0391<\/p>\n<\/td>\n | \n \u039d<\/p>\n<\/td>\n | \n \u039d<\/p>\n<\/td>\n<\/tr>\n | \n| <\/td>\n | TRH<\/td>\n | \n \u039d<\/p>\n<\/td>\n | \n \u039d<\/p>\n<\/td>\n | \n \u039c<\/p>\n<\/td>\n | \n \u039c<\/p>\n<\/td>\n<\/tr>\n | \n| <\/td>\n | GHRH<\/td>\n | \n \u039c<\/p>\n<\/td>\n | \n \u039c<\/p>\n<\/td>\n | \n \u039c<\/p>\n<\/td>\n | \n \u039c<\/p>\n<\/td>\n<\/tr>\n | \n| <\/td>\n | Somatostatin<\/td>\n | \n \u039d<\/p>\n<\/td>\n | \n \u039d<\/p>\n<\/td>\n | \n \u039d<\/p>\n<\/td>\n | \n \u039d<\/p>\n<\/td>\n<\/tr>\n | \n| \u0391\u03b4\u03b5\u03bd\u03bf\u03cb\u03c0\u03cc\u03c6\u03c5\u03c3\u03b7<\/td>\n | ACTH<\/td>\n | \n \u0391<\/p>\n<\/td>\n | \n \u0391<\/p>\n<\/td>\n | \n \u039c<\/p>\n<\/td>\n | \n \u039c<\/p>\n<\/td>\n<\/tr>\n | \n| <\/td>\n | LH<\/td>\n | \n \u0391<\/p>\n<\/td>\n | \n \u0391<\/p>\n<\/td>\n | \n \u039d<\/p>\n<\/td>\n | \n \u039c \u03ae \u039d<\/p>\n<\/td>\n<\/tr>\n | \n| <\/td>\n | FSH<\/td>\n | \n \u0391<\/p>\n<\/td>\n | \n \u0391<\/p>\n<\/td>\n | \n \u039c<\/p>\n<\/td>\n | \n \u0391<\/p>\n<\/td>\n<\/tr>\n | \n| <\/td>\n | TSH<\/td>\n | \n \u039d<\/p>\n<\/td>\n | \n \u039d<\/p>\n<\/td>\n | \n \u039d \u03ae \u039c<\/p>\n<\/td>\n | \n \u039d \u03ae \u0391<\/p>\n<\/td>\n<\/tr>\n | \n| <\/td>\n | GH<\/td>\n | \n \u039c<\/p>\n<\/td>\n | \n \u039c<\/p>\n<\/td>\n | \n \u039c<\/p>\n<\/td>\n | \n \u039c<\/p>\n<\/td>\n<\/tr>\n | \n| <\/td>\n | PRL<\/td>\n | <\/td>\n | <\/td>\n | \n \u0391<\/p>\n<\/td>\n | \n \u0391<\/p>\n<\/td>\n<\/tr>\n | \n| \u0395\u03c0\u03b9\u03bd\u03b5\u03c6\u03c1\u03af\u03b4\u03b9\u03b1<\/td>\n | \u039a\u03bf\u03c1\u03c4\u03b9\u03b6\u03cc\u03bb\u03b7<\/td>\n | \n \u0391<\/p>\n<\/td>\n | \n \u0391<\/p>\n<\/td>\n | \n \u0391<\/p>\n<\/td>\n | \n \u0391<\/p>\n<\/td>\n<\/tr>\n | \n| \u039f\u03c1\u03c7\u03b5\u03b9\u03c2<\/td>\n | \u03a4\u03b5\u03c3\u03c4\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7<\/td>\n | \n \u039c<\/p>\n<\/td>\n | \n \u039d<\/p>\n<\/td>\n | \n \u039c<\/p>\n<\/td>\n | \n \u0391<\/p>\n<\/td>\n<\/tr>\n | \n| \u03a9\u03bf\u03b8\u03ae\u03ba\u03b5\u03c2<\/td>\n | \u039f\u03b9\u03c3\u03c4\u03c1\u03b1\u03b4\u03b9\u03cc\u03bb\u03b7<\/td>\n | \n \u0391<\/p>\n<\/td>\n | \n \u0391<\/p>\n<\/td>\n | \n \u0391<\/p>\n<\/td>\n | \n \u0391<\/p>\n<\/td>\n<\/tr>\n | \n| <\/td>\n | \u03a0\u03c1\u03bf\u03b3\u03b5\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7<\/td>\n | <\/td>\n | \n \u039c<\/p>\n<\/td>\n | <\/td>\n | \n \u039c<\/p>\n<\/td>\n<\/tr>\n | \n| \u0398\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03ae\u03c2<\/td>\n | \u03a44<\/td>\n | \n \u039d<\/p>\n<\/td>\n | \n \u039d<\/p>\n<\/td>\n | \n \u039c<\/p>\n<\/td>\n | \n \u039c<\/p>\n<\/td>\n<\/tr>\n | \n| <\/td>\n | \u03a43<\/td>\n | \n \u039d<\/p>\n<\/td>\n | \n \u039d<\/p>\n<\/td>\n | \n \u039c<\/p>\n<\/td>\n | \n \u039c<\/p>\n<\/td>\n<\/tr>\n | \n| \u03a0\u03ac\u03b3\u03ba\u03c1\u03b5\u03b1\u03c2<\/td>\n | \u0399\u03bd\u03c3\u03bf\u03c5\u03bb\u03af\u03bd\u03b7<\/td>\n | \n \u039c \u03ae \u039d<\/p>\n<\/td>\n | \n \u039c \u03ae \u039d<\/p>\n<\/td>\n | \n \u039c<\/p>\n<\/td>\n | \n \u039c<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n A= \u03b1\u03cd\u03be\u03b7\u03c3\u03b7, \u039c= \u03bc\u03b5\u03af\u03c9\u03c3\u03b7, \u039d= \u03b1\u03b4\u03b9\u03ac\u03c6\u03bf\u03c1\u03b7.<\/p>\n \u0392\u03b9\u03b2\u03bb\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1<\/b><\/h4>\n\n- Doll R, Peto R, Hall E, Wheatley K, Gray R. Mortality in relation to consumption of alcohol: 13 years’ observations on male British doctors. BMJ 1994, 309:911-918.<\/li>\n
- Oneta CM, Simanowski UA, Martinez M, et al. First pass metabolism of ethanol is strikingly influenced by the speed of gastric emptying. Gut 1998, 43:612-619.<\/li>\n
- Rivier C, Lee S. Acute alcohol administration stimulates the activity of hypothalamic neurons that express corticotropin-releasing factor and vasopressin. Brain Res 1996, 726:1\u201310.<\/li>\n
- Ogilvie KM, Lee S, Rivier C. Role of arginine vasopressin and corticotropin-releasing factor in mediating alcohol-induced adrenocorticotropin and vasopressin secretion in male rats bearing lesions of the paraventricular nuclei. Brain Res 1997, 744:83\u201395.<\/li>\n
- Olive MF, Mehmert KK, Koenig HN, et al. A role for corticotropin releasing factor(CRF) in ethanol consumption, sensitivity, and reward as revealed by CRF-deficientmice. Psychopharmacology (Berl) 2003, 165:181\u20137.<\/li>\n
- Rasmussen DD, Boldt BM, Bryant CA, et al. Chronic daily ethanol and withdrawal: Long-term changes in the hypothalamo-pituitary-adrenal axis. Alcohol Clin Exp Res 2000, 24:1836\u201349.<\/li>\n
- Sarnyai Z, Shaham Y, Heinrichs SC. The role of corticotropin-releasing factor in drug addiction. Pharmacol Rev 2001, 53:209\u201343.<\/li>\n
- Thayer JF, Hall M, Sollers JJ III, et al. Alcohol use, urinary cortisol, and heart rate variability in apparently healthy men: evidence for impaired inhibitory control of the HPA axis in heavy drinkers. Int J Psychophysiol 2006, 59:244\u201350.<\/li>\n
- Gianoulakis C. Influence of the endogenous opioid system on high alcohol consumption<\/li>\n
- and genetic predisposition to alcoholism. J Psychiatry Neurosci 2001, 26:304\u201318.<\/li>\n
- Wand GS, Mangold D, Ali M, et al. Adrenocortical responses and family history of alcoholism. Alcohol Clin Exp Res 1999, 23:1185\u201390.<\/li>\n
- Starcke K, van Holst RJ, van den Brink W et al.\u00a0 Physiological and endocrine reactions to psychosocial stress in alcohol use disorders: duration of abstinence matters. Alcohol Clin Exp Res. 2013, 37(8):1343-50.<\/li>\n
- Groote Veldman R., Meinders A.E On the Mechanism of Alcohol-Induced Pseudo-Cushing’s Syndrome. Endocrine reviews 1996, Volume 17 Issue 3<\/li>\n
- Rivest S and C. Rivier C. The role of corticotropin-releasing factor and interleukin-1 in the regulation of neurons controling reproductive functions. Endocr Rev 1995, 16:177-199<\/li>\n
- Selvage D.J, Hales D.B, Rivier C.L. Comparison between the influence of the systemic and central injection of alcohol on Leydig cell activity. Alcoholism: Clin Exper Res 2004, 28:480-488.<\/li>\n
- Diamond F Jr, Ringenberg L, MacDonald D, et al. Effects of drug and alcohol abuse upon pituitary-testicular function in adolescent males. J Adolesc Health Care 1986, 7:28\u201333.<\/li>\n
- Muthusami KR, Chinnaswamy P. Effect of chronic alcoholism on male fertility hormones and semen quality. Fertil Steril 2005, 84:919\u201324.<\/li>\n
- Purohit V. Can alcohol promote aromatization of androgens to estrogens? A review. Alcohol 2000, 22:123\u20137.<\/li>\n
- Castilla-Cortazar I, Quiroga J, Prieto J. Insulin-like growth factor-I, liver function, and hypogonadism in rats with experimentally induced cirrhosis. Hepatology 2000, 31:1379.<\/li>\n
- Roser JF. Regulation of testicular function in the stallion: an intricate network of endocrine, paracrine and autocrine systems. Anim Reprod Sci 2008, 107:179\u201396.<\/li>\n
- Jensen TK, Swan S, J\u00f8rgensen N, Toppari J. <\/sup>et al. Alcohol and male reproductive health: a cross-sectional study of 8344 healthy men from Europe and the USA. Hum Reprod. 2014, 29(8):1801-9.<\/li>\n
- Jensen TK, Hjollund NH, Henriksen TB, et al. Does moderate alcohol consumption affect fertility? Follow up study among couples planning first pregnancy. BMJ 1998, 317:505\u201310.<\/li>\n
- Longnecker MP, Tseng M. Alcohol, hormones, and postmenopausal women. Alcohol Health Res World 1998, 22:185\u20139.<\/li>\n
- Koppes LL, Dekker JM, Hendriks HF, et al. Moderate alcohol consumptionlowers the risk of type 2 diabetes: a meta-analysis of prospective observationalstudies. Diabetes Care 2005, 28:719\u201325.<\/li>\n
- Freiberg MS, Cabral HJ, Heeren TC et al. Alcohol consumption and the prevalence of the Metabolic Syndrome in the US.: a cross-sectional analysis of data from the Third National Health and Nutrition Examination Survey 2004, Diabetes Care27 (12): 2954\u20139.<\/li>\n
- Conigrave KM, Hu BF, Camargo CA Jr, et al. A prospective study of drinking patternsin relation to risk of type 2 diabetes among men. Diabetes 2001, 50:2390\u20135.<\/li>\n
- Ko CH, Takahashi JS. Molecular components of the mammalian circadian clock. Hum Mol Genet 2006, 15(Spec No 2):R271\u20137.<\/li>\n
- Sarkar DK. Circadian genes, the stress axis, and alcoholism. Alcohol Res 2012; 34:362\u20136.<\/li>\n
- Perreau-Lenz S, Zghoul T, Spanagel R. Clock genes running amok. Clock genesand their role in drug addiction and depression. EMBO Rep 2007, 8(Spec No):S20\u20133.<\/li>\n
- Hegedus L, Rasmussen N, Ravn V, et al. Independent effects of liver disease and chronic alcoholism on thyroid function and size: the possibility of a toxic effect of alcohol on the thyroid gland. Metabolism 1988, 37:229\u201333.<\/li>\n
- Pienaar WP, Roberts MC, Emsley RA, et al. The thyrotropin releasing hormone stimulation test in alcoholism. Alcohol 1995, 30:661\u20137.<\/li>\n
- Valimaki M, Pelkonen R, Harkonen M, et al. Pituitary-gonadal hormones and adrenal androgens in non-cirrhotic female alcoholics after cessation of alcohol intake. Eur J Clin Invest 1990, 20:177\u201381.<\/li>\n
- De A, Boyadjieva N, Pastorcic M, et al. Potentiation of the mitogenic effect of estrogen on the pituitary-gland by alcohol-consumption. Int J Oncol 1995, 7:643\u20138.<\/li>\n
- Valimaki M, Tuominen JA, Huhtaniemi I, et al. The pulsatile secretion of gonadotropins and growth hormone, and the biological activity of luteinizing hormone in men acutely intoxicated with ethanol. Alcohol Clin Exp Res 1990, 14:928\u201331.<\/li>\n
- Tentler JJ, LaPaglia N, Steiner J, et al: Ethanol, growth hormone and testosterone in peripubertal rats. J Endocrinol 1997, 152:477\u2013487.<\/li>\n
- Soszynski PA, Frohman LA. Interaction of ethanol with signal transduction mechanisms mediating growth hormone release by rat pituitary cells in vitro. Endocrinology 1992, 131:173\u201380.<\/li>\n
- Bianco A, Thomas e, Francesco Pomara F, et al. Alcohol consumption and hormonal alterations related to muscle hypertrophy: a review. Nutrition & Metabolism 2014, 11:26<\/li>\n<\/ol>\n
\nCreated: February 25, 2015
\nLast update: February 25, 2015<\/p>\n","protected":false},"excerpt":{"rendered":" \u0391\u03bd\u03b1\u03c3\u03c4\u03ac\u03c3\u03b9\u03bf\u03c2 \u039c\u03cc\u03c1\u03c4\u03bf\u03b3\u03bb\u03bf\u03c5 \u0395\u03bd\u03b4\u03bf\u03ba\u03c1\u03b9\u03bd\u03bf\u03bb\u03cc\u03b3\u03bf\u03c2 \u03a4\u03bf\u03bc\u03ad\u03b1\u03c2 \u039c\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03c3\u03bc\u03bf\u03cd \u0399\u03b1\u03c4\u03c1\u03b9\u03ba\u03bf\u03cd \u039a\u03ad\u03bd\u03c4\u03c1\u03bf\u03c5 \u0391\u03b8\u03b7\u03bd\u03ce\u03bd 1. \u0395\u03b9\u03c3\u03b1\u03b3\u03c9\u03b3\u03ae \u03a0\u03c1\u03b9\u03bd \u03b1\u03c0\u03cc \u03bc\u03b5\u03c1\u03b9\u03ba\u03ad\u03c2 \u03b4\u03b5\u03ba\u03b1\u03b5\u03c4\u03af\u03b1\u03c2, \u03cc\u03c4\u03b1\u03bd \u03ae\u03bc\u03bf\u03c5\u03bd \u03bd\u03ad\u03bf\u03c2 \u03b5\u03bd\u03b4\u03bf\u03ba\u03c1\u03b9\u03bd\u03bf\u03bb\u03cc\u03b3\u03bf\u03c2, \u03b5\u03c0\u03b9\u03c3\u03ba\u03ad\u03c6\u03c4\u03b7\u03ba\u03b5 \u03c4\u03bf \u03b5\u03be\u03c9\u03c4\u03b5\u03c1\u03b9\u03ba\u03cc \u03b9\u03b1\u03c4\u03c1\u03b5\u03af\u03bf \u03c4\u03bf\u03c5 \u03bd\u03bf\u03c3\u03bf\u03ba\u03bf\u03bc\u03b5\u03af\u03bf\u03c5 \u03bc\u03af\u03b1 \u03ba\u03c5\u03c1\u03af\u03b1 \u03bc\u03ad\u03c3\u03b7\u03c2 \u03b7\u03bb\u03b9\u03ba\u03af\u03b1\u03c2 \u03bc\u03b5 \u03b5\u03bb\u03b1\u03c6\u03c1\u03ac \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf \u03c3\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc \u03b2\u03ac\u03c1\u03bf\u03c2, \u03c3\u03c4\u03c1\u03bf\u03b3\u03b3\u03c5\u03bb\u03cc \u03ba\u03b1\u03b9 \u03ba\u03cc\u03ba\u03ba\u03b9\u03bd\u03bf \u03c0\u03c1\u03cc\u03c3\u03c9\u03c0\u03bf, \u03b1\u03bb\u03c9\u03c0\u03b5\u03ba\u03af\u03b1, \u03c5\u03c0\u03b5\u03c1\u03c4\u03c1\u03af\u03c7\u03c9\u03c3\u03b7, \u03ba\u03bf\u03b9\u03bb\u03b9\u03b1\u03ba\u03ae \u03c0\u03b1\u03c7\u03c5\u03c3\u03b1\u03c1\u03ba\u03af\u03b1, \u03bb\u03b5\u03c0\u03c4\u03ac \u03ba\u03ac\u03c4\u03c9 \u03ac\u03ba\u03c1\u03b1 \u03ba\u03b1\u03b9 \u03c6\u03b1\u03c1\u03b4\u03b9\u03ad\u03c2 \u03ba\u03cc\u03ba\u03ba\u03b9\u03bd\u03b5\u03c2 \u03c1\u03b1\u03b2\u03b4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c3\u03b5 \u03cc\u03bb\u03bf \u03c4\u03bf \u03c3\u03ce\u03bc\u03b1. \u0388\u03b3\u03b9\u03bd\u03b5 \u03c4\u03cc\u03c4\u03b5 […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"pageCustom.php","meta":{"footnotes":""},"tags":[],"_links":{"self":[{"href":"https:\/\/e-endocrinology.gr\/index.php?rest_route=\/wp\/v2\/pages\/1086"}],"collection":[{"href":"https:\/\/e-endocrinology.gr\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/e-endocrinology.gr\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/e-endocrinology.gr\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/e-endocrinology.gr\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1086"}],"version-history":[{"count":6,"href":"https:\/\/e-endocrinology.gr\/index.php?rest_route=\/wp\/v2\/pages\/1086\/revisions"}],"predecessor-version":[{"id":1088,"href":"https:\/\/e-endocrinology.gr\/index.php?rest_route=\/wp\/v2\/pages\/1086\/revisions\/1088"}],"wp:attachment":[{"href":"https:\/\/e-endocrinology.gr\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1086"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/e-endocrinology.gr\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1086"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}} | | | | | | | |
![\"Print](\"https:\/\/cdn.printfriendly.com\/buttons\/printfriendly-pdf-button-nobg.png\")
\n <\/a>\n <\/div><\/p>\n