{"id":100566,"date":"2015-09-27T17:44:08","date_gmt":"2015-09-27T14:44:08","guid":{"rendered":"http:\/\/e-endocrinology.gr\/?page_id=100566"},"modified":"2016-03-09T13:57:04","modified_gmt":"2016-03-09T10:57:04","slug":"9-11-%ce%b1%ce%bd%ce%b4%cf%81%ce%b9%ce%ba%ce%ae-%ce%b1%ce%bd%cf%84%ce%b9%cf%83%cf%8d%ce%bb%ce%bb%ce%b7%cf%88%ce%b7","status":"publish","type":"page","link":"https:\/\/e-endocrinology.gr\/?page_id=100566","title":{"rendered":"9.11 \u0391\u03bd\u03b4\u03c1\u03b9\u03ba\u03ae \u03b1\u03bd\u03c4\u03b9\u03c3\u03cd\u03bb\u03bb\u03b7\u03c8\u03b7"},"content":{"rendered":"<p style=\"text-align: right;\"><div class=\"printfriendly pf-button  pf-alignright\">\n                    <a href=\"https:\/\/e-endocrinology.gr\/?page_id=100566&#038;pfstyle=wp\" rel=\"nofollow\" onclick=\"\" title=\"Printer Friendly, PDF & Email\">\n                    <img decoding=\"async\" class=\"pf-button-img\" src=\"https:\/\/cdn.printfriendly.com\/buttons\/printfriendly-pdf-button-nobg.png\" alt=\"Print Friendly, PDF & Email\" style=\"width: 112px;height: 24px;\"  \/>\n                    <\/a>\n                <\/div><\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: right;\"><em>\u0393\u03b5\u03ce\u03c1\u03b3\u03b9\u03bf\u03c2 \u039a\u03b1\u03bd\u03ac\u03ba\u03b7\u03c2<\/em><br \/>\n\u0395\u03bd\u03b4\u03bf\u03ba\u03c1\u03b9\u03bd\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae, \u039d\u03b1\u03c5\u03c4\u03b9\u03ba\u03cc \u039d\u03bf\u03c3\u03bf\u03ba\u03bf\u03bc\u03b5\u03af\u03bf \u0391\u03b8\u03b7\u03bd\u03ce\u03bd<\/p>\n<h4 style=\"text-align: justify;\">1. \u0395\u03b9\u03c3\u03b1\u03b3\u03c9\u03b3\u03ae<\/h4>\n<p style=\"text-align: justify;\">\u0388\u03c7\u03b5\u03b9 \u03b4\u03b5\u03b9\u03c7\u03b8\u03b5\u03af \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03ac \u03cc\u03c4\u03b9 \u03c3\u03b5 \u03ba\u03bf\u03b9\u03bd\u03c9\u03bd\u03af\u03b5\u03c2 \u03cc\u03c0\u03bf\u03c5 \u03b5\u03c0\u03b9\u03ba\u03c1\u03b1\u03c4\u03b5\u03af 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\u00ab\u03b3\u03cc\u03bd\u03b9\u03bc\u03ad\u03c2\u00bb \u03b7\u03bc\u03ad\u03c1\u03b5\u03c2 \u03c4\u03b9\u03c2 \u03bf\u03c0\u03bf\u03af\u03b5\u03c2 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03ac \u03b1\u03c0\u03bf\u03c4\u03c5\u03c7\u03af\u03b1\u03c2 \u03c0\u03b5\u03c1\u03af \u03c4\u03bf 20% \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7 \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03c4\u03bf\u03c5 \u03c0\u03c1\u03ce\u03c4\u03bf\u03c5 \u03ad\u03c4\u03bf\u03c5\u03c2 \u03c4\u03b7\u03c2 \u03b5\u03c6\u03b1\u03c1\u03bc\u03bf\u03b3\u03ae\u03c2 \u03c4\u03bf\u03c5\u03c2.<sup>3<\/sup> \u03a0\u03b1\u03c1\u03ac \u03c4\u03b9\u03c2 \u03bb\u03af\u03b3\u03b5\u03c2 \u03b4\u03b9\u03b1\u03b8\u03ad\u03c3\u03b9\u03bc\u03b5\u03c2 \u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ad\u03c2, \u03c3\u03c4\u03b7\u03bd \u03ba\u03b1\u03b8\u2019 \u03b7\u03bc\u03ad\u03c1\u03b1 \u03c0\u03c1\u03ac\u03be\u03b7 \u03bf\u03b9 \u03b1\u03bd\u03b4\u03c1\u03b9\u03ba\u03ad\u03c2 \u03b1\u03bd\u03c4\u03b9\u03c3\u03c5\u03bb\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf\u03b9 \u03b1\u03bd\u03c4\u03b9\u03c0\u03c1\u03bf\u03c3\u03c9\u03c0\u03b5\u03cd\u03bf\u03c5\u03bd \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 \u03c4\u03bf 14% \u03c4\u03b7\u03c2 \u03b1\u03bd\u03c4\u03b9\u03c3\u03cd\u03bb\u03bb\u03b7\u03c8\u03b7\u03c2 \u03c0\u03b1\u03b3\u03ba\u03bf\u03c3\u03bc\u03af\u03c9\u03c2, \u03bc\u03b5 \u03c4\u03bf \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03b1\u03c5\u03c4\u03cc \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03bf \u03c3\u03c4\u03b9\u03c2 \u03b1\u03bd\u03b5\u03c0\u03c4\u03c5\u03b3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03ba\u03bf\u03b9\u03bd\u03c9\u03bd\u03af\u03b5\u03c2, \u03cc\u03c0\u03bf\u03c5 \u03b1\u03bd\u03ad\u03c1\u03c7\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf 30%.<sup>4<\/sup><\/p>\n<p style=\"text-align: justify;\">\u03a4\u03bf \u03b3\u03b5\u03b3\u03bf\u03bd\u03cc\u03c2 \u03cc\u03c4\u03b9 \u03b1\u03ba\u03cc\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c3\u03c4\u03b1\u03c4\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1 \u03c0\u03c1\u03bf\u03b7\u03b3\u03bc\u03ad\u03bd\u03c9\u03bd \u03ba\u03bf\u03b9\u03bd\u03c9\u03bd\u03b9\u03ce\u03bd, \u03c0\u03c1\u03bf\u03ba\u03cd\u03c0\u03c4\u03b5\u03b9 \u03bc\u03b5\u03b3\u03ac\u03bb\u03bf \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03b1\u03bd\u03b5\u03c0\u03b9\u03b8\u03cd\u03bc\u03b7\u03c4\u03c9\u03bd \u03b3\u03b5\u03bd\u03bd\u03ae\u03c3\u03b5\u03c9\u03bd, \u03b5\u03c0\u03b9\u03b2\u03ac\u03bb\u03bb\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b1\u03bd\u03b1\u03b8\u03b5\u03ce\u03c1\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c5\u03c6\u03b9\u03c3\u03c4\u03ac\u03bc\u03b5\u03bd\u03c9\u03bd \u03bc\u03b5\u03b8\u03cc\u03b4\u03c9\u03bd \u03b1\u03bd\u03c4\u03b9\u03c3\u03cd\u03bb\u03bb\u03b7\u03c8\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ce\u03bd \u03c0\u03bf\u03c5 \u03b4\u03b9\u03b1\u03c4\u03af\u03b8\u03b5\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf \u03b6\u03b5\u03cd\u03b3\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03ac\u03bd\u03b4\u03c1\u03b5\u03c2. \u0395\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd, \u03bf\u03b9 \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03c3\u03b5\u03c2 \u03b3\u03c5\u03bd\u03b1\u03b9\u03ba\u03b5\u03af\u03b5\u03c2 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf\u03b9, \u03b1\u03bd \u03ba\u03b1\u03b9 \u03c0\u03bf\u03bb\u03cd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ad\u03c2, \u03b1\u03bd\u03c4\u03b5\u03bd\u03b4\u03b5\u03af\u03ba\u03bd\u03c5\u03bd\u03c4\u03b1\u03b9 \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ce\u03c2 \u03c3\u03b5 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b5\u03c2 \u03b3\u03c5\u03bd\u03b1\u03b9\u03ba\u03ce\u03bd \u03ae \u03ad\u03c7\u03bf\u03c5\u03bd \u03b4\u03c5\u03c3\u03ac\u03c1\u03b5\u03c3\u03c4\u03b5\u03c2 \u03c0\u03b1\u03c1\u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2, \u03bf\u03b9 \u03bf\u03c0\u03bf\u03af\u03b5\u03c2 \u03bf\u03b4\u03b7\u03b3\u03bf\u03cd\u03bd \u03c3\u03c4\u03b7 \u03b4\u03b9\u03b1\u03ba\u03bf\u03c0\u03ae \u03c4\u03b7\u03c2 \u03c7\u03c1\u03ae\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5\u03c2. \u0395\u03c0\u03af\u03c3\u03b7\u03c2, \u03c0\u03bf\u03bb\u03bb\u03bf\u03af \u03ac\u03bd\u03b4\u03c1\u03b5\u03c2 \u03b5\u03c0\u03b9\u03b8\u03c5\u03bc\u03bf\u03cd\u03bd \u03bd\u03b1 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03ad\u03c7\u03bf\u03c5\u03bd \u03b9\u03c3\u03cc\u03c4\u03b9\u03bc\u03b1 \u03bc\u03b5 \u03c4\u03b7 \u03c3\u03cd\u03bd\u03c4\u03c1\u03bf\u03c6\u03cc \u03c4\u03bf\u03c5\u03c2 \u03c3\u03b5 \u03b6\u03b7\u03c4\u03ae\u03bc\u03b1\u03c4\u03b1 \u03bf\u03b9\u03ba\u03bf\u03b3\u03b5\u03bd\u03b5\u03b9\u03b1\u03ba\u03bf\u03cd \u03c0\u03c1\u03bf\u03b3\u03c1\u03b1\u03bc\u03bc\u03b1\u03c4\u03b9\u03c3\u03bc\u03bf\u03cd. \u03a0\u03c1\u03ac\u03b3\u03bc\u03b1\u03c4\u03b9, \u03c3\u03b5 \u03bc\u03af\u03b1 \u03c0\u03c1\u03cc\u03c3\u03c6\u03b1\u03c4\u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7, \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf \u03b1\u03c0\u03cc 60% \u03c4\u03c9\u03bd \u03b1\u03bd\u03b4\u03c1\u03ce\u03bd \u03c3\u03c4\u03b7 \u0393\u03b5\u03c1\u03bc\u03b1\u03bd\u03af\u03b1, \u03c4\u03b7\u03bd \u0399\u03c3\u03c0\u03b1\u03bd\u03af\u03b1, \u03c4\u03b7 \u0392\u03c1\u03b1\u03b6\u03b9\u03bb\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03bf \u039c\u03b5\u03be\u03b9\u03ba\u03cc \u03ae\u03c4\u03b1\u03bd \u03c0\u03c1\u03cc\u03b8\u03c5\u03bc\u03bf\u03b9 \u03bd\u03b1 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03ae\u03c3\u03bf\u03c5\u03bd \u03bc\u03b9\u03b1 \u03bd\u03ad\u03b1 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf \u03b1\u03bd\u03b4\u03c1\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03c4\u03b9\u03c3\u03cd\u03bb\u03bb\u03b7\u03c8\u03b7\u03c2, \u03b5\u03bd\u03ce \u03c4\u03bf \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03b1\u03c5\u03c4\u03cc \u03ae\u03c4\u03b1\u03bd \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03bf \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03b1\u03bd\u03b4\u03c1\u03ce\u03bd \u03bc\u03b5 \u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03bf \u03b5\u03b9\u03c3\u03cc\u03b4\u03b7\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03b1\u03bd\u03ce\u03c4\u03b5\u03c1\u03b7 \u03b5\u03ba\u03c0\u03b1\u03af\u03b4\u03b5\u03c5\u03c3\u03b7.<sup>5<\/sup> \u0395\u03af\u03bd\u03b1\u03b9 \u03b1\u03be\u03b9\u03bf\u03c3\u03b7\u03bc\u03b5\u03af\u03c9\u03c4\u03bf \u03cc\u03c4\u03b9 98% \u03c4\u03c9\u03bd \u03b3\u03c5\u03bd\u03b1\u03b9\u03ba\u03ce\u03bd \u03c3\u03b5 \u03bc\u03b1\u03ba\u03c1\u03bf\u03c7\u03c1\u03cc\u03bd\u03b9\u03b5\u03c2 \u03c3\u03c7\u03ad\u03c3\u03b5\u03b9\u03c2 \u03b8\u03b1 \u03ae\u03c4\u03b1\u03bd \u03c0\u03c1\u03cc\u03b8\u03c5\u03bc\u03b5\u03c2 \u03bd\u03b1 \u03b2\u03b1\u03c3\u03b9\u03c3\u03c4\u03bf\u03cd\u03bd \u03c3\u03c4\u03bf\u03c5\u03c2 \u03c3\u03c5\u03bd\u03c4\u03c1\u03cc\u03c6\u03bf\u03c5\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03c7\u03c1\u03ae\u03c3\u03b7 \u03b1\u03bd\u03c4\u03b9\u03c3\u03cd\u03bb\u03bb\u03b7\u03c8\u03b7\u03c2.<sup>6<\/sup><\/p>\n<p style=\"text-align: justify;\">\u0394\u03c5\u03c3\u03c4\u03c5\u03c7\u03ce\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03b1\u03c1\u03ac \u03c4\u03b9\u03c2 \u03b5\u03c5\u03bd\u03bf\u03ca\u03ba\u03ad\u03c2 \u03ba\u03bf\u03b9\u03bd\u03c9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03c0\u03c1\u03bf\u03cb\u03c0\u03bf\u03b8\u03ad\u03c3\u03b5\u03b9\u03c2, \u03b7 \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03b2\u03b9\u03bf\u03bc\u03b7\u03c7\u03b1\u03bd\u03af\u03b1 \u03c4\u03b1 \u03c4\u03b5\u03bb\u03b5\u03c5\u03c4\u03b1\u03af\u03b1 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03b1\u03c0\u03bf\u03c3\u03cd\u03c1\u03b5\u03b9 \u03c4\u03bf \u03b5\u03bd\u03b4\u03b9\u03b1\u03c6\u03ad\u03c1\u03bf\u03bd \u03c4\u03b7\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1 \u03c3\u03c4\u03bf\u03bd \u03c4\u03bf\u03bc\u03ad\u03b1 \u03c4\u03b7\u03c2 \u03b1\u03bd\u03b4\u03c1\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03c4\u03b9\u03c3\u03cd\u03bb\u03bb\u03b7\u03c8\u03b7\u03c2. \u0397 \u03bc\u03af\u03b1 \u03ba\u03b1\u03b9 \u03bc\u03bf\u03bd\u03b1\u03b4\u03b9\u03ba\u03ae \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7, \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c7\u03c1\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03bf\u03c4\u03ae\u03b8\u03b7\u03ba\u03b5 \u03c0\u03c1\u03bf 6\u03b5\u03c4\u03af\u03b1\u03c2 \u03b1\u03c0\u03cc \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03b5\u03c5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b5\u03c4\u03b1\u03b9\u03c1\u03b5\u03af\u03b5\u03c2, \u03b5\u03b3\u03ba\u03b1\u03c4\u03b1\u03bb\u03b5\u03af\u03c6\u03b8\u03b7\u03ba\u03b5 \u03c0\u03b1\u03c1\u03ac \u03c4\u03b1 \u03b5\u03c5\u03bf\u03af\u03c9\u03bd\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03ac \u03c4\u03b7\u03c2.<sup>7<\/sup> \u03a3\u03ae\u03bc\u03b5\u03c1\u03b1 \u03b7 \u03c7\u03c1\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03cc\u03c4\u03b7\u03c3\u03b7 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03ce\u03bd \u03c0\u03c1\u03bf\u03b3\u03c1\u03b1\u03bc\u03bc\u03ac\u03c4\u03c9\u03bd \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03bd\u03b4\u03c1\u03b9\u03ba\u03ae \u03b1\u03bd\u03c4\u03b9\u03c3\u03cd\u03bb\u03bb\u03b7\u03c8\u03b7 \u03c0\u03c1\u03bf\u03ba\u03cd\u03c0\u03c4\u03b5\u03b9 \u03bc\u03cc\u03bd\u03bf \u03b1\u03c0\u03cc \u03b4\u03b7\u03bc\u03cc\u03c3\u03b9\u03b1 \u03c0\u03c1\u03bf\u03b3\u03c1\u03ac\u03bc\u03bc\u03b1\u03c4\u03b1, \u03b4\u03b9\u03b5\u03b8\u03bd\u03b5\u03af\u03c2 \u03bf\u03c1\u03b3\u03b1\u03bd\u03ce\u03c3\u03b5\u03b9\u03c2 (\u03a0\u039f\u03a5) \u03ba\u03b1\u03b9 \u03c6\u03b9\u03bb\u03b1\u03bd\u03b8\u03c1\u03c9\u03c0\u03b9\u03ba\u03ac \u03b9\u03b4\u03c1\u03cd\u03bc\u03b1\u03c4\u03b1 (Population Council, \u039d\u03ad\u03b1 \u03a5\u03cc\u03c1\u03ba\u03b7).<\/p>\n<h4 style=\"text-align: justify;\">2. \u0399\u03b4\u03b1\u03bd\u03b9\u03ba\u03ae \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03c5\u03c0\u03b1\u03c1\u03c7\u03bf\u03c5\u03c3\u03ce\u03bd \u03bc\u03b5\u03b8\u03cc\u03b4\u03c9\u03bd \u03b1\u03bd\u03c4\u03b9\u03c3\u03cd\u03bb\u03bb\u03b7\u03c8\u03b7\u03c2<\/h4>\n<p style=\"text-align: justify;\">\u0397 \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 \u03bc\u03b9\u03b1\u03c2 \u03bd\u03ad\u03b1\u03c2 \u03bc\u03b5\u03b8\u03cc\u03b4\u03bf\u03c5 \u03b1\u03bd\u03b4\u03c1\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03c4\u03b9\u03c3\u03cd\u03bb\u03bb\u03b7\u03c8\u03b7\u03c2 \u03b8\u03b1 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03b9\u03b4\u03b1\u03bd\u03b9\u03ba\u03ac \u03bd\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03c4\u03b1 \u03b5\u03be\u03ae\u03c2 \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac:<sup>8<\/sup><\/p>\n<ol>\n<li>\u00a0\u039d\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03cc\u03c3\u03bf \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03cc\u03c3\u03bf \u03c4\u03bf\u03c5\u03bb\u03ac\u03c7\u03b9\u03c3\u03c4\u03bf\u03bd \u03bf\u03b9 \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03c2 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b3\u03c5\u03bd\u03b1\u03af\u03ba\u03b1.<\/li>\n<li>\u00a0\u039d\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03bf\u03b4\u03b5\u03ba\u03c4\u03ae \u03ba\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5\u03c2 \u03b4\u03cd\u03bf \u03c3\u03c5\u03bd\u03c4\u03c1\u03cc\u03c6\u03bf\u03c5\u03c2.<\/li>\n<li>\u00a0\u039d\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03b3\u03c1\u03ae\u03b3\u03bf\u03c1\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1.<\/li>\n<li>\u00a0\u039d\u03b1 \u03bc\u03b7\u03bd \u03ad\u03c7\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b1\u03c1\u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2, \u03b9\u03b4\u03af\u03c9\u03c2 \u03c3\u03b5 \u03c3\u03c7\u03ad\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b1\u03c1\u03c1\u03b5\u03bd\u03c9\u03c0\u03cc\u03c4\u03b7\u03c4\u03b1, \u03c4\u03b7 \u03bb\u03af\u03bc\u03c0\u03b9\u03bd\u03c4\u03bf \u03ba\u03b1\u03b9 \u03c4\u03b7 \u03c3\u03c4\u03c5\u03c4\u03b9\u03ba\u03ae \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1.<\/li>\n<li>\u00a0\u039d\u03b1 \u03bc\u03b7\u03bd \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03b5\u03b9 \u03c4\u03bf\u03c5\u03c2 \u03b1\u03c0\u03bf\u03b3\u03cc\u03bd\u03bf\u03c5\u03c2.<\/li>\n<li>\u00a0\u039d\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03c1\u03ad\u03c8\u03b9\u03bc\u03b7 \u03c3\u03b5 \u03c3\u03c7\u03ad\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b7 \u03b3\u03bf\u03bd\u03b9\u03bc\u03cc\u03c4\u03b7\u03c4\u03b1.<\/li>\n<li>\u00a0\u039d\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03cd\u03ba\u03bf\u03bb\u03b1 \u03b4\u03b9\u03b1\u03b8\u03ad\u03c3\u03b9\u03bc\u03b7 \u03ba\u03b1\u03b9 \u03bf\u03b9\u03ba\u03bf\u03bd\u03bf\u03bc\u03b9\u03ba\u03ac \u03c0\u03c1\u03bf\u03c3\u03b9\u03c4\u03ae.<\/li>\n<\/ol>\n<p style=\"text-align: justify;\">\u039f\u03b9 \u03b1\u03bd\u03b4\u03c1\u03b9\u03ba\u03ad\u03c2 \u03b1\u03bd\u03c4\u03b9\u03c3\u03c5\u03bb\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf\u03b9, \u03b1\u03bd\u03b1\u03bb\u03cc\u03b3\u03c9\u03c2 \u03c4\u03bf\u03c5 \u03c3\u03c4\u03cc\u03c7\u03bf\u03c5 \u03b4\u03c1\u03ac\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c4\u03ac\u03c3\u03c3\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03c4\u03c1\u03b5\u03b9\u03c2 \u03b2\u03b1\u03c3\u03b9\u03ba\u03ad\u03c2 \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b5\u03c2 :<\/p>\n<ol>\n<li>\u00a0\u03a3\u03b5 \u03cc\u03c3\u03b5\u03c2 \u03c0\u03b1\u03c1\u03b5\u03bc\u03c0\u03bf\u03b4\u03af\u03b6\u03bf\u03c5\u03bd \u03c4\u03b7 \u03bc\u03b5\u03c4\u03b1\u03c6\u03bf\u03c1\u03ac \u03c4\u03bf\u03c5 \u03c3\u03c0\u03ad\u03c1\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c3\u03c4\u03bf \u03b3\u03b5\u03bd\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc \u03c3\u03cd\u03c3\u03c4\u03b7\u03bc\u03b1 \u03c4\u03b7\u03c2 \u03b3\u03c5\u03bd\u03b1\u03af\u03ba\u03b1\u03c2.<\/li>\n<li>\u00a0\u03a3\u03b5 \u03cc\u03c3\u03b5\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03c5\u03bd \u03c4\u03b7 \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7 \u03ba\u03b1\u03b9<\/li>\n<li>\u00a0\u03a3\u03b5 \u03b1\u03c5\u03c4\u03ad\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03b1\u03b2\u03bb\u03ac\u03c0\u03c4\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03c9\u03c1\u03af\u03bc\u03b1\u03bd\u03c3\u03b7 \u03ae \u03c4\u03b7 \u03b3\u03bf\u03bd\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03ae \u03b9\u03ba\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03c9\u03bd \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b6\u03c9\u03b1\u03c1\u03af\u03c9\u03bd.<\/li>\n<\/ol>\n<p style=\"text-align: justify;\">\u039a\u03b1\u03b9 \u03bf\u03b9 2 \u03c5\u03c6\u03b9\u03c3\u03c4\u03ac\u03bc\u03b5\u03bd\u03b5\u03c2 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf\u03b9 \u03b1\u03bd\u03b4\u03c1\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03c4\u03b9\u03c3\u03cd\u03bb\u03bb\u03b7\u03c8\u03b7\u03c2 (\u03c0\u03c1\u03bf\u03c6\u03c5\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03cc, \u03b2\u03b1\u03b6\u03b5\u03ba\u03c4\u03bf\u03bc\u03ae) \u03b1\u03bd\u03ae\u03ba\u03bf\u03c5\u03bd \u03c3\u03c4\u03b7\u03bd \u03c0\u03c1\u03ce\u03c4\u03b7 \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b1, \u03c9\u03c3\u03c4\u03cc\u03c3\u03bf \u03b1\u03c0\u03ad\u03c7\u03bf\u03c5\u03bd \u03b1\u03c0\u03cc \u03c4\u03b1 \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03c4\u03b7\u03c2 \u03b9\u03b4\u03b1\u03bd\u03b9\u03ba\u03ae\u03c2 \u03bc\u03b5\u03b8\u03cc\u03b4\u03bf\u03c5. \u039a\u03cd\u03c1\u03b9\u03bf \u03bc\u03b5\u03b9\u03bf\u03bd\u03ad\u03ba\u03c4\u03b7\u03bc\u03b1 \u03c4\u03bf\u03c5 \u03bc\u03b5\u03bd \u03c0\u03c1\u03bf\u03c6\u03c5\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03bf\u03cd \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03b1 \u03c5\u03c8\u03b7\u03bb\u03ac \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03ac \u03b1\u03c0\u03bf\u03c4\u03c5\u03c7\u03af\u03b1\u03c2, \u03c4\u03b7\u03c2 \u03b4\u03b5 \u03b2\u03b1\u03b6\u03b5\u03ba\u03c4\u03bf\u03bc\u03ae\u03c2 \u03b7 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b7 \u03b1\u03bd\u03c4\u03b9\u03c3\u03c4\u03c1\u03b5\u03c8\u03b9\u03bc\u03cc\u03c4\u03b7\u03c4\u03b1.<\/p>\n<hr style=\"width: 100%; border-width: 1px; border-style: solid; border-color: #CCCCCC; color: #ffffff;\" noshade=\"noshade\" width=\"100%\" \/>\n<p>\u039f\u03b9 \u03ba\u03c5\u03c1\u03b9\u03ce\u03c4\u03b5\u03c1\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03bf\u03cd \u03b1\u03bd\u03b4\u03c1\u03bf\u03b3\u03cc\u03bd\u03c9\u03bd \u03bc\u03b5 \u03c0\u03c1\u03bf\u03b3\u03b5\u03c3\u03c4\u03b1\u03b3\u03cc\u03bd\u03b1 \u03c9\u03c2 \u03bf\u03c1\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03b1\u03bd\u03b4\u03c1\u03b9\u03ba\u03ae \u03b1\u03bd\u03c4\u03b9\u03c3\u03cd\u03bb\u03bb\u03b7\u03c8\u03b7.<\/p>\n<table style=\"width: 30%;\" border=\"0\" cellspacing=\"3\" cellpadding=\"3\" align=\"center\">\n<tbody>\n<tr style=\"background-color: #385a72;\">\n<td><span style=\"color: #ffffff;\"><b>\u039c\u03b5\u03bb\u03ad\u03c4\u03b7<\/b><\/span><\/td>\n<td><span style=\"color: #ffffff;\"><b>\u0388\u03c4\u03bf\u03c2 \u03b4\u03b7\u03bc\u03bf\/\u03c3\u03b7\u03c2<\/b><\/span><\/td>\n<td><span style=\"color: #ffffff;\"><b>\u039d\u03bf. \u0392\u03b9\u03b2\u03bb\/\u03ba\u03ae\u03c2 \u03a0\u03b1\u03c1\/\u03c0\u03ae\u03c2<\/b><\/span><\/td>\n<td><span style=\"color: #ffffff;\"><b>\u03a6\u03c5\u03bb\u03ae <\/b><\/span><span style=\"color: #ffffff;\"><b>\u03c3\u03c5\u03bc\/\u03c7\u03cc\u03bd\u03c4\u03c9\u03bd <\/b><\/span><\/td>\n<td colspan=\"2\"><span style=\"color: #ffffff;\"><b>\u0394\u03cc\u03c3\u03b7<br \/>\n\u03b1\u03bd\u03b4\u03c1\u03bf\u03b3\u03cc\u03bd\u03bf\u03c5\u00a0<\/b><\/span><\/td>\n<td colspan=\"2\"><span style=\"color: #ffffff;\"><b>\u0394\u03cc\u03c3\u03b7 \u03c0\u03c1\u03bf\u03b3\u03b5\u03c3\u03c4\u03b1\u03b3\u03cc\u03bd\u03bf\u03c5<\/b><\/span><\/td>\n<td><span style=\"color: #ffffff;\"><b>\u0391\u03c1\u03b9\u03b8\u03bc\u03cc\u03c2 <\/b><\/span><span style=\"color: #ffffff;\"><b>\u03b1\u03bd\u03b4\u03c1\u03ce\u03bd<\/b><b><\/b><\/span><\/td>\n<td><span style=\"color: #ffffff;\"><b>\u0395\u03c0\u03af\u03c4\u03b5\u03c5\u03be\u03b7 <\/b><\/span><span style=\"color: #ffffff;\"><b>\u03bf\u03bb\u03b9\u03b3\u03bf\u03b6\u03c9\u03bf<br \/>\n\u03c3\u03c0\u03b5\u03c1\u03bc\u03af\u03b1\u03c2<br \/>\n&lt;10<sup>6\/<\/sup><\/b><b>ml<\/b><b>,(<\/b><b>n<\/b><b>,%)<\/b><\/span><\/td>\n<td><span style=\"color: #ffffff;\"><b>\u03a3\u03c7\u03cc\u03bb\u03b9\u03b1<\/b><\/span><\/td>\n<\/tr>\n<tr>\n<td>Meriggiola et al.,<\/td>\n<td>2005<\/td>\n<td>53<\/td>\n<td>\u039a\u03b1\u03c5\u03ba\u03ac\u03c3\u03b9\u03bf\u03b9<\/td>\n<td>TU<\/td>\n<td>1000 mg\u00a0 i.m.\/8 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2<\/td>\n<td>NETE<\/td>\n<td>200 mg\u00a0 i.m\/ 6 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2<\/td>\n<td>10<\/td>\n<td>9 (90%)<\/td>\n<td>\u03a3\u03c5\u03b3\u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03bc\u03b5 \u03b5\u03bd\u03ad\u03c3\u03b9\u03bc\u03b7 TU<\/td>\n<\/tr>\n<tr>\n<td>Gui et al.,<\/td>\n<td>2004<\/td>\n<td>54<\/td>\n<td>\u039a\u03b9\u03bd\u03ad\u03b6\u03bf\u03b9<\/td>\n<td>TU<\/td>\n<td>500 \u03ae 1000 mg\u00a0 i.m\/8 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2<\/td>\n<td>LNG<\/td>\n<td>4 \u0395\u03bc\u03c6\u03c5\u03c4\u03b5\u03cd\u03bc\u03b1\u03c4\u03b1<\/td>\n<td>41<\/td>\n<td>36 (90%)<\/td>\n<td>\u0395\u03bb\u03ac\u03c4\u03c4\u03c9\u03c3\u03b7 HDL-\u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2<\/td>\n<\/tr>\n<tr>\n<td>Turner et al.,<\/td>\n<td>2003<\/td>\n<td>57<\/td>\n<td>\u039d\u0391<\/td>\n<td>\u0395\u03bc\u03c6\u03c5\u03c4\u03b5\u03cd\u03bc\u03b1\u03c4\u03b1 \u03a4<\/td>\n<td>800 mg\u00a0 i.m\/16 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2<\/td>\n<td>DMPA<\/td>\n<td>300 mg\u00a0 i.m\/ 12 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2<\/td>\n<td>55<\/td>\n<td>53 (96%)<\/td>\n<td>\u039c\u03b5\u03bb\u03ad\u03c4\u03b7 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2<\/td>\n<\/tr>\n<tr>\n<td>Gu et al.,<\/td>\n<td>2004<\/td>\n<td>58<\/td>\n<td>\u039a\u03b9\u03bd\u03ad\u03b6\u03bf\u03b9<\/td>\n<td>TU<\/td>\n<td>1000 mg\u00a0 i.m\/8 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2<\/td>\n<td>DMPA<\/td>\n<td>150 \u03ae 300 mg\u00a0 i.m.\/ 8 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2<\/td>\n<td>30<\/td>\n<td>29 (97%)<\/td>\n<td>\u03a0\u03b1\u03c1\u03b1\u03c4\u03b5\u03c4\u03b1\u03bc\u03ad\u03bd\u03b7 \u03b4\u03c1\u03ac\u03c3\u03b7<\/td>\n<\/tr>\n<tr>\n<td>Meriggiola et al.,<\/td>\n<td>1996<\/td>\n<td>59<\/td>\n<td>\u039a\u03b1\u03c5\u03ba\u03ac\u03c3\u03b9\u03bf\u03b9<\/td>\n<td>TE<\/td>\n<td>100 mg im\/\u0395\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b1<\/td>\n<td>CPA<\/td>\n<td>50 mg p.o.\/day<\/td>\n<td>5<\/td>\n<td>5 (100%)<\/td>\n<td>\u0399\u03c3\u03c7\u03c5\u03c1\u03ae \u03b1\u03bd\u03c4\u03b9\u03b1\u03bd\u03b4\u03c1\u03bf\u03b3\u03cc\u03bd\u03bf\u03c2 \u03b4\u03c1\u03ac\u03c3\u03b7 CPA<\/td>\n<\/tr>\n<tr>\n<td>Meriggiola et al.,<\/td>\n<td>1996<\/td>\n<td>59<\/td>\n<td>\u039a\u03b1\u03c5\u03ba\u03ac\u03c3\u03b9\u03bf\u03b9<\/td>\n<td>TE<\/td>\n<td>100 mg i.m.\/\u0395\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b1<\/td>\n<td>CPA<\/td>\n<td>100 mg p.o.\/day<\/td>\n<td>5<\/td>\n<td>5 (100%)<\/td>\n<\/tr>\n<tr>\n<td>Meriggiala et al.,<\/td>\n<td>\n<p style=\"text-align: left;\" align=\"center\">2003<\/p>\n<\/td>\n<td>\n<p align=\"center\">60<\/p>\n<\/td>\n<td>\u039a\u03b1\u03c5\u03ba\u03ac\u03c3\u03b9\u03bf\u03b9<\/td>\n<td>TU<\/td>\n<td>1000 mg\/6 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2<\/td>\n<td>CPA<\/td>\n<td>20 &amp; 2 mg p.o.\/day<\/td>\n<td>24<\/td>\n<td>24 (100%)<\/td>\n<\/tr>\n<tr>\n<td>Ilani et al.,<\/td>\n<td>2012<\/td>\n<td>61<\/td>\n<td>\u039c\u03b9\u03ba\u03c4\u03cc\u03c2 \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03cc\u03c2<\/td>\n<td>T gel<\/td>\n<td>10g \u03b7\u03bc\u03b5\u03c1\u03b7\u03c3\u03af\u03c9\u03c2<\/td>\n<td>NES gel<\/td>\n<td>8g \u03ae 12g \u03b7\u03bc\u03b5\u03c1\u03b7\u03c3\u03af\u03c9\u03c2<\/td>\n<td>56<\/td>\n<td>50 (88,5%)<\/td>\n<td>\u039c\u03b5\u03b3\u03ac\u03bb\u03b7 \u03b1\u03c0\u03bf\u03b4o\u03c7\u03ae<\/td>\n<\/tr>\n<tr>\n<td>Anderson et al.,<\/td>\n<td>2002<\/td>\n<td>63<\/td>\n<td>\u039a\u03b1\u03c5\u03ba\u03ac\u03c3\u03b9\u03bf\u03b9<\/td>\n<td>\u0395\u03bc\u03c6\u03c5\u03c4\u03b5\u03cd\u03bc\u03b1\u03c4\u03b1 \u03a4<\/td>\n<td>400 mg\/12 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2<\/td>\n<td>ENG<\/td>\n<td>1 \u03c1\u03ac\u03b2\u03b4\u03bf\u03c2(Implanon)<\/td>\n<td>14<\/td>\n<td>11 (79%)<\/td>\n<td rowspan=\"2\">\u03a7\u03c9\u03c1\u03af\u03c2 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03ba\u03ad\u03c2 \u03b5\u03c0\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2<\/td>\n<\/tr>\n<tr>\n<td>Anderson et al.,<\/td>\n<td>2002<\/td>\n<td>63<\/td>\n<td>\u039a\u03b1\u03c5\u03ba\u03ac\u03c3\u03b9\u03bf\u03b9<\/td>\n<td>\u0395\u03bc\u03c6\u03c5\u03c4\u03b5\u03cd\u03bc\u03b1\u03c4\u03b1 \u03a4<\/td>\n<td>400 mg\/12 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2<\/td>\n<td>ENG<\/td>\n<td>2 \u03c1\u03ac\u03b2\u03b4\u03bf\u03b9 (Implanon)<\/td>\n<td>14<\/td>\n<td>13 (93%)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>TU Testosterone Undecanoate, TE\u00a0 Testosterone Enanthate, NETE Norethisterone Enanthate, LNG Levonorgestrel, DMPA Medroxyprogesterone depot, CPA Cyproterone Acetate, NES Nestorone, ENG Etonogestrel<\/p>\n<hr style=\"width: 100%; border-width: 1px; border-style: solid; border-color: #CCCCCC; color: #ffffff;\" noshade=\"noshade\" width=\"100%\" \/>\n<p>&nbsp;<\/p>\n<h5 style=\"text-align: justify;\">2.1. \u03a0\u03c1\u03bf\u03c6\u03c5\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ac<\/h5>\n<p style=\"text-align: justify;\">\u03a4\u03bf \u03c0\u03c1\u03bf\u03c6\u03c5\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03cc \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03c0\u03b1\u03bb\u03b1\u03b9\u03cc\u03c4\u03b5\u03c1\u03b7 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf\u03c2 \u03b1\u03bd\u03c4\u03b9\u03c3\u03cd\u03bb\u03bb\u03b7\u03c8\u03b7\u03c2, \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03b1\u03bd\u03b1\u03c6\u03ad\u03c1\u03b5\u03c4\u03b1\u03b9 \u03c0\u03c1\u03ce\u03c4\u03b7 \u03c6\u03bf\u03c1\u03ac \u03c0\u03c1\u03b9\u03bd \u03b1\u03c0\u03cc 300 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd \u0386\u03b3\u03b3\u03bb\u03bf \u03b3\u03b9\u03b1\u03c4\u03c1\u03cc Condom, \u03bf \u03bf\u03c0\u03bf\u03af\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bd\u03ad\u03c3\u03c4\u03b7\u03c3\u03b5 \u03c4\u03b7\u03bd \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03ae \u03c0\u03c1\u03bf\u03c6\u03c5\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ce\u03bd \u03b1\u03c0\u03cc \u03c4\u03bf \u03ad\u03bd\u03c4\u03b5\u03c1\u03bf \u03b1\u03c1\u03bd\u03b9\u03bf\u03cd. \u03a4\u03bf \u03c0\u03c1\u03bf\u03c6\u03c5\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03cc \u03bb\u03b1\u03c4\u03ad\u03be \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03ac\u03c3\u03c4\u03b7\u03ba\u03b5 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd Goodyear (1800-1860), \u03c9\u03c3\u03c4\u03cc\u03c3\u03bf \u03b7 \u03b2\u03b9\u03bf\u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03ba\u03ae \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03c4\u03bf\u03c5 \u03c7\u03c1\u03bf\u03bd\u03bf\u03bb\u03bf\u03b3\u03b5\u03af\u03c4\u03b1\u03b9 \u03c4\u03bf 1920. \u03a3\u03c4\u03b7 \u03b4\u03b5\u03ba\u03b1\u03b5\u03c4\u03af\u03b1 \u03c4\u03bf\u03c5 1990 \u03b5\u03b9\u03c3\u03ae\u03bb\u03b8\u03b1\u03bd \u03c3\u03c4\u03b7\u03bd \u03b1\u03b3\u03bf\u03c1\u03ac \u03c0\u03c1\u03bf\u03c6\u03c5\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ac \u03b1\u03c0\u03cc \u03c0\u03bf\u03bb\u03c5\u03bf\u03c5\u03c1\u03b5\u03b8\u03ac\u03bd\u03b7, \u03b5\u03bd\u03ce \u03c4\u03bf 2004 \u03bf \u03a0\u039f\u03a5 \u03b8\u03ad\u03c3\u03c0\u03b9\u03c3\u03b5 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03c5\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ad\u03c2 \u03b5\u03b9\u03b4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03c1\u03bf\u03b4\u03b9\u03b1\u03b3\u03c1\u03b1\u03c6\u03ad\u03c2.<sup>9<\/sup><\/p>\n<p style=\"text-align: justify;\">\u03a0\u03c1\u03bf\u03c6\u03c5\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ac \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03c3\u03ae\u03bc\u03b5\u03c1\u03b1 \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 5,7% \u03c4\u03c9\u03bd \u03b6\u03b5\u03c5\u03b3\u03b1\u03c1\u03b9\u03ce\u03bd \u03c0\u03b1\u03b3\u03ba\u03bf\u03c3\u03bc\u03af\u03c9\u03c2 \u03c9\u03c2 \u03b1\u03bd\u03c4\u03b9\u03c3\u03c5\u03bb\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03ae \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf, \u03bc\u03b5 \u03c4\u03bf \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03b1\u03c5\u03c4\u03cc \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03bf \u03c3\u03c4\u03b9\u03c2 \u03b1\u03bd\u03b1\u03c0\u03c4\u03c5\u03b3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03c7\u03ce\u03c1\u03b5\u03c2. \u0388\u03c4\u03c3\u03b9, \u03c3\u03c4\u03b9\u03c2 \u0397\u03a0\u0391 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd \u03c4\u03bf \u03c0\u03c1\u03bf\u03c6\u03c5\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03cc \u03c9\u03c2 \u03b1\u03bd\u03c4\u03b9\u03c3\u03cd\u03bb\u03bb\u03b7\u03c8\u03b7 20% \u03c4\u03c9\u03bd \u03b6\u03b5\u03c5\u03b3\u03b1\u03c1\u03b9\u03ce\u03bd, \u03c3\u03c4\u03b7 \u0393\u03b5\u03c1\u03bc\u03b1\u03bd\u03af\u03b1 25%, \u03b5\u03bd\u03ce \u03c3\u03c4\u03b7\u03bd \u0399\u03b1\u03c0\u03c9\u03bd\u03af\u03b1 \u03c3\u03c7\u03b5\u03b4\u03cc\u03bd \u03c4\u03bf 80%.<sup>10<\/sup> \u0392\u03b1\u03c3\u03b9\u03ba\u03cc \u03bc\u03b5\u03b9\u03bf\u03bd\u03ad\u03ba\u03c4\u03b7\u03bc\u03b1 \u03c4\u03bf\u03c5 \u03c0\u03c1\u03bf\u03c6\u03c5\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03bf\u03cd \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03b1 \u03c7\u03b1\u03bc\u03b7\u03bb\u03ac \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03ac \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7\u03bd \u03c4\u03c5\u03c0\u03b9\u03ba\u03ae \u03ba\u03b1\u03b8\u03b7\u03bc\u03ad\u03c1\u03b1 \u03c7\u03c1\u03ae\u03c3\u03b7, \u03ba\u03b1\u03b8\u03ce\u03c2 \u03c5\u03c0\u03bf\u03bb\u03bf\u03b3\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b9 19 \u03b1\u03c0\u03cc \u03c4\u03b1 100 \u03b6\u03b5\u03c5\u03b3\u03ac\u03c1\u03b9\u03b1 \u03b8\u03b1 \u03c3\u03c5\u03bb\u03bb\u03ac\u03b2\u03b5\u03b9 \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7 \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03c4\u03bf\u03c5 \u03c0\u03c1\u03ce\u03c4\u03bf\u03c5 \u03ad\u03c4\u03bf\u03c5\u03c2 \u03c4\u03b7\u03c2 \u03c7\u03c1\u03ae\u03c3\u03b7\u03c2 \u03c0\u03c1\u03bf\u03c6\u03c5\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03bf\u03cd.<sup>11<\/sup> \u00a0\u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03b1\u03ba\u03cc\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03cc\u03c4\u03b1\u03bd \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c9\u03c3\u03c4\u03ac, \u03b7 \u03c1\u03ae\u03be\u03b7 \u03ba\u03b1\u03b9 \u03b7 \u03bf\u03bb\u03af\u03c3\u03b8\u03b7\u03c3\u03b7 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c0\u03ac\u03bd\u03b9\u03b5\u03c2, \u03ba\u03b1\u03b8\u03ce\u03c2 \u03c3\u03c5\u03bc\u03b2\u03b1\u03af\u03bd\u03bf\u03c5\u03bd \u03c3\u03b5 \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc 2-8% \u03c4\u03c9\u03bd \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03c9\u03bd.<sup>12<\/sup> \u03a3\u03b5 \u03b3\u03b5\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b3\u03c1\u03b1\u03bc\u03bc\u03ad\u03c2, \u03cc\u03c3\u03bf \u03c0\u03b1\u03bb\u03b1\u03b9\u03cc\u03c4\u03b5\u03c1\u03bf \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf \u03c0\u03c1\u03bf\u03c6\u03c5\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03cc \u03c4\u03cc\u03c3\u03bf \u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03bf\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2 \u03c1\u03ae\u03be\u03b7\u03c2 \u03c4\u03bf\u03c5.<sup>13<\/sup> \u00a0\u0392\u03b1\u03c3\u03b9\u03ba\u03cc \u03c0\u03bb\u03b5\u03bf\u03bd\u03ad\u03ba\u03c4\u03b7\u03bc\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03c0\u03c1\u03bf\u03c3\u03c4\u03b1\u03c3\u03af\u03b1 \u03b1\u03c0\u03cc \u03c3\u03b5\u03be\u03bf\u03c5\u03b1\u03bb\u03b9\u03ba\u03ce\u03c2 \u03bc\u03b5\u03c4\u03b1\u03b4\u03b9\u03b4\u03cc\u03bc\u03b5\u03bd\u03b1 \u03bd\u03bf\u03c3\u03ae\u03bc\u03b1\u03c4\u03b1, \u03c9\u03c3\u03c4\u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03b1\u03c5\u03c4\u03ae\u03bd \u03c4\u03b7\u03bd \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03b7 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b9\u03ba\u03b1\u03bd\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03ae.<sup>14<\/sup><\/p>\n<h5 style=\"text-align: justify;\">2.2.\u00a0 \u0391\u03c0\u03bf\u03bb\u03af\u03bd\u03c9\u03c3\u03b7 \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03b9\u03ba\u03ce\u03bd \u03c0\u03cc\u03c1\u03c9\u03bd (\u0392\u03b1\u03b6\u03b5\u03ba\u03c4\u03bf\u03bc\u03ae)<\/h5>\n<p style=\"text-align: justify;\">\u03a9\u03c2 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf\u03c2 \u03b1\u03bd\u03c4\u03b9\u03c3\u03cd\u03bb\u03bb\u03b7\u03c8\u03b7\u03c2\u00a0\u03b7 \u03b1\u03c0\u03bf\u03bb\u03af\u03bd\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03b9\u03ba\u03ce\u03bd \u03c0\u03cc\u03c1\u03c9\u03bd \u03ba\u03b1\u03c4\u03ad\u03c3\u03c4\u03b7 \u03b4\u03b7\u03bc\u03bf\u03c6\u03b9\u03bb\u03ae\u03c2 \u03c3\u03c4\u03b7 \u03b4\u03b5\u03ba\u03b1\u03b5\u03c4\u03af\u03b1 \u03c4\u03bf\u03c5 1960, \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c3\u03c4\u03b9\u03c2 \u0397\u03a0\u0391.<sup>15<\/sup> \u03a3\u03ae\u03bc\u03b5\u03c1\u03b1, \u03b7 \u03b2\u03b1\u03b6\u03b5\u03ba\u03c4\u03bf\u03bc\u03ae \u03b5\u03c0\u03b9\u03bb\u03ad\u03b3\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf 2,7% \u03c4\u03c9\u03bd \u03b6\u03b5\u03c5\u03b3\u03b1\u03c1\u03b9\u03ce\u03bd \u03c0\u03bf\u03c5 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd \u03b1\u03bd\u03c4\u03b9\u03c3\u03cd\u03bb\u03bb\u03b7\u03c8\u03b7 (10% \u03c3\u03c4\u03b9\u03c2 \u0397\u03a0\u0391) \u03ba\u03b1\u03b9 \u03c0\u03ac\u03bd\u03c9 \u03b1\u03c0\u03cc 40 \u03b5\u03ba\u03b1\u03c4\u03bf\u03bc\u03bc\u03cd\u03c1\u03b9\u03b1 \u03ac\u03bd\u03b4\u03c1\u03b5\u03c2 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c5\u03c0\u03bf\u03b2\u03bb\u03b7\u03b8\u03b5\u03af \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ac \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03ad\u03bc\u03b2\u03b1\u03c3\u03b7.<sup>16<\/sup> \u0397 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03bf\u03cd\u03bc\u03b5\u03bd\u03b7 \u03b1\u03bd\u03b1\u03bd\u03c4\u03b9\u03c3\u03c4\u03bf\u03b9\u03c7\u03af\u03b1 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03c0\u03c1\u03bf\u03b7\u03b3\u03bc\u03ad\u03bd\u03c9\u03bd \u03ba\u03b1\u03b9 \u03b1\u03bd\u03b1\u03c0\u03c4\u03c5\u03c3\u03c3\u03cc\u03bc\u03b5\u03bd\u03c9\u03bd \u03c7\u03c9\u03c1\u03ce\u03bd \u03b5\u03b4\u03c1\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c3\u03b5 \u03c0\u03bf\u03bb\u03b9\u03c4\u03b9\u03c3\u03bc\u03b9\u03ba\u03bf\u03cd\u03c2 \/ \u03b8\u03c1\u03b7\u03c3\u03ba\u03b5\u03c5\u03c4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c1\u03b9\u03c3\u03bc\u03bf\u03cd\u03c2, \u03b5\u03bd\u03ce \u03b7 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b9\u03bf \u03b4\u03b7\u03bc\u03bf\u03c6\u03b9\u03bb\u03ae\u03c2 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03b1\u03bd\u03b4\u03c1\u03ce\u03bd \u03b1\u03bd\u03ce\u03c4\u03b5\u03c1\u03bf\u03c5 \u03bc\u03bf\u03c1\u03c6\u03c9\u03c4\u03b9\u03ba\u03bf\u03cd \u03b5\u03c0\u03b9\u03c0\u03ad\u03b4\u03bf\u03c5.<sup>17<\/sup><\/p>\n<p style=\"text-align: justify;\">\u039a\u03b1\u03c4\u03ac \u03c4\u03b7\u03bd \u03b5\u03c0\u03ad\u03bc\u03b2\u03b1\u03c3\u03b7 \u03b4\u03b9\u03b1\u03c4\u03ad\u03bc\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bf \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c2 \u03c0\u03cc\u03c1\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03b5\u03af \u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03c0\u03b7\u03be\u03af\u03b1 \u03ae \u03c7\u03b7\u03bc\u03b9\u03ba\u03ae \u03bc\u03b5\u03c4\u03bf\u03c5\u03c3\u03af\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03ba\u03bf\u03bb\u03bf\u03b2\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd. \u03a0\u03c1\u03cc\u03ba\u03b5\u03b9\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03bc\u03af\u03b1 \u03c4\u03b5\u03c7\u03bd\u03b9\u03ba\u03ae \u03c5\u03c8\u03b7\u03bb\u03ae\u03c2 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2, \u03bc\u03b5 \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03ac \u03b1\u03c0\u03bf\u03c4\u03c5\u03c7\u03af\u03b1\u03c2 &lt;1% \u03ba\u03b1\u03b9 \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03b5\u03c0\u03b9\u03c0\u03bb\u03bf\u03ba\u03ce\u03bd.<sup>11<\/sup> \u039c\u03b5 \u03c4\u03b9\u03c2 \u03c3\u03cd\u03b3\u03c7\u03c1\u03bf\u03bd\u03b5\u03c2 \u03b5\u03bb\u03ac\u03c7\u03b9\u03c3\u03c4\u03b1 \u03b5\u03c0\u03b5\u03bc\u03b2\u03b1\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c4\u03b5\u03c7\u03bd\u03b9\u03ba\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b7 \u03c7\u03c1\u03ae\u03c3\u03b7 \u03b5\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03ce\u03bd, \u03bf \u03c7\u03c1\u03cc\u03bd\u03bf\u03c2 \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1\u03c2 \u03c4\u03b7\u03c2 \u03b5\u03c0\u03ad\u03bc\u03b2\u03b1\u03c3\u03b7\u03c2 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\u03bf\u03c0\u03bf\u03af\u03c9\u03bd \u03b1\u03b3\u03b3\u03af\u03b6\u03b5\u03b9 \u03c4\u03bf 3,5%.<sup>21<\/sup> \u039f\u03b9 \u03c3\u03cd\u03b3\u03c7\u03c1\u03bf\u03bd\u03b5\u03c2 \u03c4\u03b5\u03c7\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b1\u03bd\u03b1\u03c3\u03c4\u03cc\u03bc\u03c9\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03b9\u03ba\u03ce\u03bd \u03c0\u03cc\u03c1\u03c9\u03bd \u03bc\u03b5 \u03c7\u03c1\u03ae\u03c3\u03b7 \u03bc\u03b9\u03ba\u03c1\u03bf\u03c3\u03ba\u03bf\u03c0\u03af\u03bf\u03c5 \u03b5\u03c0\u03b9\u03c4\u03c5\u03b3\u03c7\u03ac\u03bd\u03bf\u03c5\u03bd \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03ac \u03b1\u03c0\u03bf\u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03b2\u03b1\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c4\u03b7\u03c2 \u03c4\u03ac\u03be\u03b7\u03c2 \u03c4\u03bf\u03c5 90%.<sup>22<\/sup> \u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03c4\u03b1 \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03ac \u03b5\u03c0\u03af\u03c4\u03b5\u03c5\u03be\u03b7\u03c2 \u03b5\u03b3\u03ba\u03c5\u03bc\u03bf\u03c3\u03cd\u03bd\u03b7\u03c2 \u03c5\u03c0\u03bf\u03bb\u03b5\u03af\u03c0\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03b1\u03c5\u03c4\u03ce\u03bd \u03c4\u03c9\u03bd \u03c4\u03b9\u03bc\u03ce\u03bd, \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03bb\u03b9\u03b3\u03cc\u03c4\u03b5\u03c1\u03bf\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5\u03c2 \u03bc\u03b9\u03c3\u03bf\u03cd\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bd\u03b1 \u03ba\u03b1\u03b8\u03af\u03c3\u03c4\u03b1\u03bd\u03c4\u03b1\u03b9 \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03b3\u03cc\u03bd\u03b9\u03bc\u03bf\u03b9.<sup>23<\/sup> H \u03b1\u03bd\u03b1\u03bd\u03c4\u03b9\u03c3\u03c4\u03bf\u03b9\u03c7\u03af\u03b1 \u03b1\u03c5\u03c4\u03ae \u03b4\u03cd\u03bd\u03b1\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03bf\u03c6\u03b5\u03af\u03bb\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b5\u03ba \u03bd\u03ad\u03bf\u03c5 \u03b1\u03c0\u03cc\u03c6\u03c1\u03b1\u03be\u03b7 \u03c4\u03bf\u03c5 \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03b9\u03ba\u03bf\u03cd \u03c0\u03cc\u03c1\u03bf\u03c5 (~3%) \u03ae \u03c3\u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 \u03b1\u03bd\u03c4\u03b9\u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03b9\u03ba\u03ce\u03bd \u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd, \u03c4\u03b1 \u03bf\u03c0\u03bf\u03af\u03b1 \u03b1\u03bd\u03b9\u03c7\u03bd\u03b5\u03cd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03ad\u03c9\u03c2 \u03ba\u03b1\u03b9 70% \u03cc\u03c3\u03c9\u03bd \u03ad\u03c7\u03bf\u03c5\u03bd \u03c5\u03c0\u03bf\u03b2\u03bb\u03b7\u03b8\u03b5\u03af \u03c3\u03b5 \u03b2\u03b1\u03b6\u03b5\u03ba\u03c4\u03bf\u03bc\u03ae \u03ba\u03b1\u03b9 \u03b7 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 \u03c4\u03bf\u03c5\u03c2, \u03b9\u03b4\u03af\u03c9\u03c2 \u03c4\u03c9\u03bd IgA, \u03c3\u03c5\u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03bc\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b1\u03c0\u03bf\u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03b3\u03bf\u03bd\u03b9\u03bc\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2.<sup>24<\/sup> \u039a\u03b1\u03b8\u03bf\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03cc\u03c2 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03c0\u03bf\u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7 \u03ae \u03bc\u03b7 \u03c4\u03b7\u03c2 \u03b3\u03bf\u03bd\u03b9\u03bc\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf \u03c7\u03c1\u03bf\u03bd\u03b9\u03ba\u03cc \u03b4\u03b9\u03ac\u03c3\u03c4\u03b7\u03bc\u03b1 \u03c0\u03bf\u03c5 \u03ad\u03c7\u03b5\u03b9 \u03c0\u03b1\u03c1\u03ad\u03bb\u03b8\u03b5\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b2\u03b1\u03b6\u03b5\u03ba\u03c4\u03bf\u03bc\u03ae, \u03ba\u03b1\u03b8\u03ce\u03c2 \u03bf\u03b9 \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b5\u03c2 \u03bc\u03b5\u03b9\u03ce\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7 \u03b4\u03b9\u03b5\u03c4\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c0\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03ac \u03b5\u03be\u03b1\u03bb\u03b5\u03af\u03c6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5\u03c4\u03ac \u03c4\u03b1 10 \u03ad\u03c4\u03b7.<sup>25<\/sup> \u0397 \u03ba\u03c1\u03c5\u03bf\u03c3\u03c5\u03bd\u03c4\u03ae\u03c1\u03b7\u03c3\u03b7 \u03c3\u03c0\u03ad\u03c1\u03bc\u03b1\u03c4\u03bf\u03c2 \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7 \u03b2\u03b1\u03b6\u03b5\u03ba\u03c4\u03bf\u03bc\u03ae \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03b5\u03b9 \u03bc\u03b9\u03b1 \u03b9\u03ba\u03b1\u03bd\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03ae \u03b5\u03bd\u03b1\u03bb\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ae \u03bb\u03cd\u03c3\u03b7 \u03b1\u03bd\u03c4\u03af \u03c4\u03b7\u03c2 \u03b5\u03c0\u03b1\u03bd\u03b5\u03c0\u03ad\u03bc\u03b2\u03b1\u03c3\u03b7\u03c2.<\/p>\n<h4 style=\"text-align: justify;\">3. \u039f\u03c1\u03bc\u03bf\u03bd\u03b9\u03ba\u03ad\u03c2 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf\u03b9 \u03b1\u03bd\u03c4\u03b9\u03c3\u03cd\u03bb\u03bb\u03b7\u03c8\u03b7\u03c2<\/h4>\n<p style=\"text-align: justify;\">\u039f\u03b9 \u03bf\u03c1\u03bc\u03bf\u03bd\u03b9\u03ba\u03ad\u03c2 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf\u03b9 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03bf\u03cd\u03bd \u03c4\u03b9\u03c2 \u03bc\u03cc\u03bd\u03b5\u03c2 \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03b5\u03c5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b1\u03bd\u03c4\u03b9\u03c3\u03c5\u03bb\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03b8\u03cc\u03b4\u03bf\u03c5\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03ac\u03bd\u03b4\u03c1\u03b1 \u03bf\u03b9 \u03bf\u03c0\u03bf\u03af\u03b5\u03c2 \u03bc\u03ad\u03c7\u03c1\u03b9 \u03c3\u03ae\u03bc\u03b5\u03c1\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c5\u03c0\u03bf\u03b2\u03bb\u03b7\u03b8\u03b5\u03af \u03c3\u03b5 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2. \u0394\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03b1\u03bd\u03b1\u03bb\u03bf\u03b3\u03af\u03b1\u03c2 \u03b4\u03c1\u03ac\u03c3\u03b7\u03c2 \u03bc\u03b5 \u03c4\u03bf \u03b3\u03c5\u03bd\u03b1\u03b9\u03ba\u03b5\u03af\u03bf \u03b1\u03bd\u03c4\u03b9\u03c3\u03c5\u03bb\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03cc \u03c7\u03ac\u03c0\u03b9, \u03c3\u03c5\u03c7\u03bd\u03ac \u03b1\u03bd\u03b1\u03c6\u03ad\u03c1\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c9\u03c2 \u03c4\u03bf \u00ab\u03b1\u03bd\u03b4\u03c1\u03b9\u03ba\u03cc \u03c7\u03ac\u03c0\u03b9\u00bb, \u03c9\u03c3\u03c4\u03cc\u03c3\u03bf \u03bc\u03b5 \u03c4\u03b1 \u03bc\u03ad\u03c7\u03c1\u03b9 \u03c4\u03ce\u03c1\u03b1 \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1, \u03b5\u03ac\u03bd \u03c0\u03c1\u03cc\u03ba\u03b5\u03b9\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03c5\u03c0\u03ac\u03c1\u03be\u03b5\u03b9 \u03c3\u03cd\u03bd\u03c4\u03bf\u03bc\u03b1 \u03ba\u03ac\u03c0\u03bf\u03b9\u03b1 \u03b5\u03bc\u03c0\u03bf\u03c1\u03b9\u03ba\u03ac \u03b5\u03ba\u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03b5\u03cd\u03c3\u03b9\u03bc\u03b7 \u03bc\u03bf\u03c1\u03c6\u03ae \u03b1\u03bd\u03b4\u03c1\u03b9\u03ba\u03bf\u03cd \u03bf\u03c1\u03bc\u03bf\u03bd\u03b9\u03ba\u03bf\u03cd \u03b1\u03bd\u03c4\u03b9\u03c3\u03c5\u03bb\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03bf\u03cd, \u03b1\u03c5\u03c4\u03ae \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03bd \u03b8\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c7\u03bf\u03c1\u03b7\u03b3\u03bf\u03cd\u03bc\u03b5\u03bd\u03b7 \u03c0\u03b1\u03c1\u03b5\u03bd\u03c4\u03b5\u03c1\u03b9\u03ba\u03ac.<\/p>\n<h5 style=\"text-align: justify;\">3.1. \u03a6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03b1\u03bd\u03b4\u03c1\u03b9\u03ba\u03ae\u03c2 \u03bf\u03c1\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03c4\u03b9\u03c3\u03cd\u03bb\u03bb\u03b7\u03c8\u03b7\u03c2<\/h5>\n<p style=\"text-align: justify;\">\u0397 \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 \u03bc\u03b9\u03b1\u03c2 \u03b1\u03bd\u03b1\u03c3\u03c4\u03c1\u03ad\u03c8\u03b9\u03bc\u03b7\u03c2 \u03bf\u03c1\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03c4\u03b9\u03c3\u03c5\u03bb\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03ae\u03c2 \u03bc\u03b5\u03b8\u03cc\u03b4\u03bf\u03c5 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03ac\u03bd\u03b4\u03c1\u03b1, \u03b2\u03b1\u03c3\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b9\u03c2 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b5\u03c2 \u03b9\u03b4\u03b9\u03cc\u03c4\u03b7\u03c4\u03b5\u03c2 \u03c4\u03bf\u03c5 \u03ac\u03be\u03bf\u03bd\u03b1 \u03c5\u03c0\u03bf\u03b8\u03b1\u03bb\u03ac\u03bc\u03bf\u03c5 \u2013 \u03c5\u03c0\u03cc\u03c6\u03c5\u03c3\u03b7\u03c2 \u2013 \u03b3\u03bf\u03bd\u03ac\u03b4\u03c9\u03bd, \u03bf \u03bf\u03c0\u03bf\u03af\u03bf\u03c2 \u03c1\u03c5\u03b8\u03bc\u03af\u03b6\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03c4\u03b5\u03c3\u03c4\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5\u03c2 \u03cc\u03c1\u03c7\u03b5\u03b9\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7. \u03a3\u03cd\u03bc\u03c6\u03c9\u03bd\u03b1 \u03bc\u03b5 \u03c4\u03bf \u03ba\u03b1\u03b8\u03b9\u03b5\u03c1\u03c9\u03bc\u03ad\u03bd\u03bf \u03bc\u03bf\u03bd\u03c4\u03ad\u03bb\u03bf, \u03b7 \u03c0\u03b1\u03bb\u03bc\u03b9\u03ba\u03ae \u03b1\u03c0\u03b5\u03bb\u03b5\u03c5\u03b8\u03ad\u03c1\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b5\u03ba\u03bb\u03c5\u03c4\u03b9\u03ba\u03ae\u03c2 \u03bf\u03c1\u03bc\u03cc\u03bd\u03b7\u03c2 \u03c4\u03c9\u03bd \u03b3\u03bf\u03bd\u03b1\u03b4\u03bf\u03c4\u03c1\u03bf\u03c0\u03b9\u03bd\u03ce\u03bd (GnRH) \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd \u03c5\u03c0\u03bf\u03b8\u03ac\u03bb\u03b1\u03bc\u03bf \u03b4\u03b9\u03b5\u03b3\u03b5\u03af\u03c1\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b1\u03c0\u03b5\u03bb\u03b5\u03c5\u03b8\u03ad\u03c1\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c9\u03c7\u03c1\u03b9\u03bd\u03bf\u03c4\u03c1\u03cc\u03c0\u03bf\u03c5 \u03bf\u03c1\u03bc\u03cc\u03bd\u03b7\u03c2 (LH) \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03c9\u03bf\u03b8\u03c5\u03bb\u03b1\u03ba\u03b9\u03bf\u03c4\u03c1\u03cc\u03c0\u03bf\u03c5 \u03bf\u03c1\u03bc\u03cc\u03bd\u03b7\u03c2 (FSH) \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03c5\u03c0\u03cc\u03c6\u03c5\u03c3\u03b7. H LH \u03bc\u03b5 \u03c4\u03b7 \u03c3\u03b5\u03b9\u03c1\u03ac \u03c4\u03b7\u03c2, \u03b4\u03c1\u03b1 \u03c3\u03c4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 Leydig, \u03b4\u03b9\u03b5\u03b3\u03b5\u03af\u03c1\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03c4\u03b5\u03c3\u03c4\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7\u03c2, \u03b5\u03bd\u03ce \u03b7 FSH \u03b4\u03c1\u03b1 \u03c3\u03c4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 Sertoli \u03c0\u03c1\u03bf\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7 \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7. \u0397 \u03cd\u03c0\u03b1\u03c1\u03be\u03b7 \u03ba\u03c5\u03ba\u03bb\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 \u03b1\u03bd\u03ac\u03c3\u03c4\u03c1\u03bf\u03c6\u03b7\u03c2 \u03b1\u03bb\u03bb\u03b7\u03bb\u03bf\u03c4\u03c1\u03bf\u03c6\u03bf\u03b4\u03cc\u03c4\u03b7\u03c3\u03b7\u03c2 (feedback) \u03b5\u03c0\u03b9\u03c4\u03c1\u03ad\u03c0\u03b5\u03b9 \u03c3\u03c4\u03b7\u03bd \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03bf\u03cd\u03c3\u03b1 \u03c4\u03b5\u03c3\u03c4\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7 \u03bd\u03b1 \u03c1\u03c5\u03b8\u03bc\u03af\u03b6\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03c4\u03b7\u03c2 \u03b4\u03c1\u03ce\u03bd\u03c4\u03b1\u03c2 \u03b1\u03bd\u03b1\u03c3\u03c4\u03b1\u03bb\u03c4\u03b9\u03ba\u03ac \u03c3\u03c4\u03bf \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03bf \u03c4\u03bf\u03c5 \u03c5\u03c0\u03bf\u03b8\u03b1\u03bb\u03ac\u03bc\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03c5\u03c0\u03cc\u03c6\u03c5\u03c3\u03b7\u03c2.<sup>9<\/sup><\/p>\n<p style=\"text-align: justify;\">\u03a3\u03cd\u03bc\u03c6\u03c9\u03bd\u03b1 \u03bc\u03b5 \u03c4\u03b1 \u03b1\u03bd\u03c9\u03c4\u03ad\u03c1\u03c9, \u03b7 \u03b5\u03be\u03c9\u03b3\u03b5\u03bd\u03ae\u03c2 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03c4\u03b5\u03c3\u03c4\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae GnRH, FSH \u03ba\u03b1\u03b9 LH, \u03c0\u03b1\u03c1\u03b5\u03bc\u03c0\u03bf\u03b4\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03c2 \u03ad\u03c4\u03c3\u03b9 \u03c4\u03b7\u03bd \u03b5\u03bd\u03b4\u03bf\u03b3\u03b5\u03bd\u03ae \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03c4\u03b5\u03c3\u03c4\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7\u03c2 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03cc\u03c1\u03c7\u03b5\u03b9\u03c2 \u03ba\u03b1\u03b9, \u03b5\u03bd \u03c3\u03c5\u03bd\u03b5\u03c7\u03b5\u03af\u03b1, \u03c4\u03b7 \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7. \u0391\u03c0\u03cc\u03c3\u03c5\u03c1\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b5\u03be\u03c9\u03b3\u03b5\u03bd\u03bf\u03cd\u03c2 \u03c4\u03b5\u03c3\u03c4\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7\u03c2 \u03ad\u03c7\u03b5\u03b9 \u03c9\u03c2 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03b7\u03bd \u03b5\u03c0\u03b1\u03bd\u03b1\u03c6\u03bf\u03c1\u03ac \u03c4\u03b7\u03c2 \u03b5\u03bd\u03b4\u03bf\u03b3\u03b5\u03bd\u03bf\u03cd\u03c2 \u03ad\u03ba\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd \u03b1\u03bd\u03c9\u03c4\u03ad\u03c1\u03c9 \u03bf\u03c1\u03bc\u03bf\u03bd\u03ce\u03bd \u03ba\u03b1\u03b9 \u03c4\u03b5\u03bb\u03b9\u03ba\u03ac \u03c4\u03b7\u03bd \u03b5\u03c0\u03b1\u03bd\u03ad\u03bd\u03b1\u03c1\u03be\u03b7 \u03c4\u03b7\u03c2 \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7\u03c2.<sup>26<\/sup> \u039c\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c3\u03b5 \u03c0\u03c1\u03c9\u03c4\u03b5\u03cd\u03bf\u03bd\u03c4\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b4\u03b5\u03af\u03be\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03b7\u03c2 FSH \u03ba\u03b1\u03b9 \u03bc\u03cc\u03bd\u03bf (\u03c0.\u03c7. \u03bc\u03b5 \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1) \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03b5 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c3\u03c5\u03b3\u03ba\u03ad\u03bd\u03c4\u03c1\u03c9\u03c3\u03b7\u03c2 \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b6\u03c9\u03b1\u03c1\u03af\u03c9\u03bd \u03b1\u03bb\u03bb\u03ac \u03cc\u03c7\u03b9 \u03c3\u03b5 \u03b1\u03b6\u03c9\u03bf\u03c3\u03c0\u03b5\u03c1\u03bc\u03af\u03b1, \u03c4\u03bf\u03bd\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03c2 \u03ad\u03c4\u03c3\u03b9 \u03c4\u03b7 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1 \u03c4\u03b7\u03c2 \u03b5\u03bd\u03b4\u03bf-\u03bf\u03c1\u03c7\u03b9\u03ba\u03ae\u03c2 \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae\u03c2 \u03c4\u03b5\u03c3\u03c4\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7\u03c2 \u03c3\u03c4\u03b7 \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7<sup>27<\/sup>. \u03a3\u03b5 \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03c0\u03bf\u03c5 \u03b7 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03c9\u03bd \u03b3\u03bf\u03bd\u03b1\u03b4\u03bf\u03c4\u03c1\u03bf\u03c0\u03b9\u03bd\u03ce\u03bd \u03b5\u03c0\u03b9\u03c4\u03b5\u03c5\u03c7\u03b8\u03b5\u03af \u03bc\u03b5 \u03ac\u03bb\u03bb\u03b7 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf \u03c7\u03c9\u03c1\u03af\u03c2 \u03b1\u03bd\u03b4\u03c1\u03bf\u03b3\u03bf\u03bd\u03b9\u03ba\u03ae \u03b4\u03c1\u03ac\u03c3\u03b7 (\u03c0.\u03c7. \u03c0\u03c1\u03bf\u03b3\u03b5\u03c3\u03c4\u03b1\u03b3\u03cc\u03bd\u03bf, GnRH \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1), \u03b5\u03c0\u03b9\u03b2\u03ac\u03bb\u03bb\u03b5\u03c4\u03b1\u03b9 \u03c4\u03b1\u03c5\u03c4\u03cc\u03c7\u03c1\u03bf\u03bd\u03b7 \u03b1\u03b3\u03c9\u03b3\u03ae \u03c5\u03c0\u03bf\u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03b1\u03bb\u03b8\u03b5\u03af\u03c3\u03b1\u03c2 \u03b5\u03bd\u03b4\u03bf\u03b3\u03b5\u03bd\u03bf\u03cd\u03c2 \u03c4\u03b5\u03c3\u03c4\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03c0\u03c1\u03cc\u03bb\u03b7\u03c8\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03bd\u03b4\u03c1\u03bf\u03b3\u03bf\u03bd\u03bf\u03c0\u03b5\u03bd\u03af\u03b1\u03c2.<\/p>\n<p style=\"text-align: justify;\">\u0395\u03c0\u03b5\u03b9\u03b4\u03ae \u03ad\u03bd\u03b1\u03c2 \u03ba\u03cd\u03ba\u03bb\u03bf\u03c2 \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7\u03c2 \u03b4\u03b9\u03b1\u03c1\u03ba\u03b5\u03af \u03c0\u03b5\u03c1\u03af \u03c4\u03b9\u03c2 72 \u03b7\u03bc\u03ad\u03c1\u03b5\u03c2, \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03bc\u03af\u03b1 \u03ba\u03b1\u03b8\u03c5\u03c3\u03c4\u03ad\u03c1\u03b7\u03c3\u03b7 2 \u03ad\u03c9\u03c2 3 \u03bc\u03b7\u03bd\u03ce\u03bd \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03ad\u03bd\u03b1\u03c1\u03be\u03b7 \u03c4\u03c9\u03bd \u03bf\u03c1\u03bc\u03bf\u03bd\u03b9\u03ba\u03ce\u03bd \u03b1\u03bd\u03c4\u03b9\u03c3\u03c5\u03bb\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03ce\u03bd \u03bc\u03ad\u03c7\u03c1\u03b9 \u03c4\u03b7\u03c2 \u03b5\u03c0\u03af\u03c4\u03b5\u03c5\u03be\u03b7\u03c2 \u03c0\u03bb\u03ae\u03c1\u03bf\u03c5\u03c2 \u03b1\u03bd\u03c4\u03b9\u03c3\u03c5\u03bb\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b4\u03c1\u03ac\u03c3\u03b7\u03c2, \u03ba\u03b1\u03b8\u03c5\u03c3\u03c4\u03ad\u03c1\u03b7\u03c3\u03b7 \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b1\u03c1\u03cc\u03bc\u03bf\u03b9\u03b1 \u03bc\u03b5 \u03b5\u03ba\u03b5\u03af\u03bd\u03b7 \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03b2\u03b1\u03b6\u03b5\u03ba\u03c4\u03bf\u03bc\u03ae.<\/p>\n<p style=\"text-align: justify;\">\u03a3\u03c5\u03bd\u03bf\u03c0\u03c4\u03b9\u03ba\u03ac, \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03b5\u03c0\u03b9\u03c4\u03c5\u03b3\u03c7\u03ac\u03bd\u03b5\u03b9 \u03c4\u03bf\u03c5\u03c2 \u03c3\u03c4\u03cc\u03c7\u03bf\u03c5\u03c2 \u03c4\u03b7\u03c2 \u03b7 \u03bf\u03c1\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03b1\u03bd\u03c4\u03b9\u03c3\u03cd\u03bb\u03bb\u03b7\u03c8\u03b7 \u03c3\u03c4\u03bf\u03bd \u03ac\u03bd\u03b4\u03c1\u03b1 \u03b8\u03b1 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b5\u03be\u03b1\u03c3\u03c6\u03b1\u03bb\u03af\u03b6\u03b5\u03c4\u03b1\u03b9:<\/p>\n<ol style=\"text-align: justify;\" start=\"1\">\n<li>K\u03b1\u03c4\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03cc\u03c3\u03bf \u03c4\u03b7\u03c2 LH \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 FSH<\/li>\n<li>M\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b5\u03bd\u03b4\u03bf-\u03bf\u03c1\u03c7\u03b9\u03ba\u03ae\u03c2 \u03c4\u03b5\u03c3\u03c4\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7\u03c2 \u03b3\u03b9\u03b1 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03b7\u03c2 \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7\u03c2<\/li>\n<li>Y\u03c0\u03bf\u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03bf\u03cd\u03c3\u03b7\u03c2 \u03c4\u03b5\u03c3\u03c4\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7\u03c2 \u03b3\u03b9\u03b1 \u03c0\u03c1\u03cc\u03bb\u03b7\u03c8\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03bd\u03b4\u03c1\u03bf\u03b3\u03bf\u03bd\u03bf\u03c0\u03b5\u03bd\u03af\u03b1\u03c2.<\/li>\n<\/ol>\n<p style=\"text-align: justify;\">\u03a4\u03b5\u03bb\u03b9\u03ba\u03cc\u03c2 \u03c3\u03c4\u03cc\u03c7\u03bf\u03c2 \u03c4\u03b7\u03c2 \u03bf\u03c1\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03c4\u03b9\u03c3\u03cd\u03bb\u03bb\u03b7\u03c8\u03b7\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf \u03b1\u03c1\u03b9\u03b8\u03bc\u03cc\u03c2 \u03c4\u03c9\u03bd \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b6\u03c9\u03b1\u03c1\u03af\u03c9\u03bd \u03c3\u03c4\u03b7\u03bd \u03b5\u03ba\u03c3\u03c0\u03b5\u03c1\u03bc\u03ac\u03c4\u03b9\u03c3\u03b7 \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03cc\u03c3\u03bf \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc\u03c2, \u03ce\u03c3\u03c4\u03b5 \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03b4\u03cd\u03bd\u03b1\u03c4\u03b7 \u03b7 \u03b3\u03bf\u03bd\u03b9\u03bc\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7. \u0399\u03b4\u03b1\u03bd\u03b9\u03ba\u03cc\u03c2 \u03c3\u03c4\u03cc\u03c7\u03bf\u03c2 \u03b5\u03c0\u03bf\u03bc\u03ad\u03bd\u03c9\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03b5\u03c0\u03af\u03c4\u03b5\u03c5\u03be\u03b7 \u03b1\u03b6\u03c9\u03bf\u03c3\u03c0\u03b5\u03c1\u03bc\u03af\u03b1\u03c2. \u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03ac \u03b5\u03b3\u03ba\u03c5\u03bc\u03bf\u03c3\u03cd\u03bd\u03b7\u03c2 \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03bf\u03b9\u03c7\u03b1 \u03c7\u03b1\u03bc\u03b7\u03bb\u03ac \u03bc\u03b5 \u03c4\u03b7 \u03c7\u03c1\u03ae\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b3\u03c5\u03bd\u03b1\u03b9\u03ba\u03b5\u03af\u03bf\u03c5 \u03b1\u03bd\u03c4\u03b9\u03c3\u03c5\u03bb\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03bf\u03cd \u03c7\u03b1\u03c0\u03b9\u03bf\u03cd \u03b5\u03c0\u03b9\u03c4\u03c5\u03b3\u03c7\u03ac\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03bc\u03b5 \u03c3\u03c5\u03b3\u03ba\u03ad\u03bd\u03c4\u03c1\u03c9\u03c3\u03b7 \u03c9\u03c2 \u03ba\u03b1\u03b9 1 \u03b5\u03ba\u03b1\u03c4\u03bf\u03bc\u03bc\u03cd\u03c1\u03b9\u03bf \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b6\u03c9\u03ac\u03c1\u03b9\u03b1 \/ ml, \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03ba\u03b1\u03b9 \u03b8\u03b5\u03c9\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03c0\u03bf\u03b4\u03b5\u03ba\u03c4\u03ae.<sup>28<\/sup><\/p>\n<h5 style=\"text-align: justify;\">3.2. \u039c\u03bf\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03b1\u03bd\u03b4\u03c1\u03bf\u03b3\u03cc\u03bd\u03c9\u03bd<\/h5>\n<p style=\"text-align: justify;\">\u0389\u03b4\u03b7 \u03b1\u03c0\u03cc \u03c4\u03b7 \u03b4\u03b5\u03ba\u03b1\u03b5\u03c4\u03af\u03b1 \u03c4\u03bf\u03c5 1930 \u03b5\u03af\u03c7\u03b5 \u03b4\u03b5\u03b9\u03c7\u03b8\u03b5\u03af \u03b7 \u03b1\u03bd\u03b1\u03c3\u03c4\u03b1\u03bb\u03c4\u03b9\u03ba\u03ae \u03b4\u03c1\u03ac\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c4\u03b5\u03c3\u03c4\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7\u03c2 \u03c3\u03c4\u03bf\u03bd \u03ac\u03be\u03bf\u03bd\u03b1 \u03c4\u03c9\u03bd \u03b3\u03bf\u03bd\u03b1\u03b4\u03bf\u03c4\u03c1\u03bf\u03c0\u03b9\u03bd\u03ce\u03bd, \u03c9\u03c3\u03c4\u03cc\u03c3\u03bf \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae \u03c0\u03c1\u03bf\u03c3\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1 \u03c0\u03c1\u03bf\u03c2 \u03c4\u03b7\u03bd \u03ba\u03b1\u03c4\u03b5\u03cd\u03b8\u03c5\u03bd\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03bd\u03b4\u03c1\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03c4\u03b9\u03c3\u03cd\u03bb\u03bb\u03b7\u03c8\u03b7\u03c2 \u03be\u03b5\u03ba\u03af\u03bd\u03b7\u03c3\u03b5 \u03bc\u03b5\u03c4\u03ac \u03c4\u03bf 1970. \u03a3\u03c4\u03b9\u03c2 \u03bc\u03ad\u03c7\u03c1\u03b9 \u03c4\u03ce\u03c1\u03b1 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2, \u03b7 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03b5\u03be\u03c9\u03b3\u03b5\u03bd\u03bf\u03cd\u03c2 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7\u03c2 \u03c4\u03b5\u03c3\u03c4\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7\u03c2 \u03b1\u03b3\u03b3\u03af\u03b6\u03b5\u03b9 \u03c4\u03bf 95%, \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03c4\u03bf \u03bf\u03c0\u03bf\u03af\u03bf \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03bb\u03b1\u03c6\u03c1\u03ce\u03c2 \u03c5\u03c0\u03bf\u03b4\u03b5\u03ad\u03c3\u03c4\u03b5\u03c1\u03bf \u03c4\u03c9\u03bd \u03b3\u03c5\u03bd\u03b1\u03b9\u03ba\u03b5\u03af\u03c9\u03bd \u03b1\u03bd\u03c4\u03b9\u03c3\u03c5\u03bb\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03ce\u03bd \u03bc\u03b5\u03b8\u03cc\u03b4\u03c9\u03bd.<\/p>\n<h6 style=\"text-align: justify;\">3.2.1. \u0395\u03bd\u03b1\u03bd\u03b8\u03b9\u03ba\u03ae \u03c4\u03b5\u03c3\u03c4\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7<\/h6>\n<p style=\"text-align: justify;\">\u0395\u03bd\u03b1\u03bd\u03b8\u03b9\u03ba\u03ae \u03a4\u03b5\u03c3\u03c4\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7 (\u03a4\u0395) \u03c7\u03bf\u03c1\u03b7\u03b3\u03ae\u03b8\u03b7\u03ba\u03b5 \u03c3\u03b5 2 \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03c0\u03c1\u03bf\u03b1\u03bd\u03b1\u03c6\u03b5\u03c1\u03b8\u03b5\u03af\u03c3\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2, \u03bf\u03b9 \u03bf\u03c0\u03bf\u03af\u03b5\u03c2 \u03c7\u03c1\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03bf\u03c4\u03ae\u03b8\u03b7\u03ba\u03b1\u03bd \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd \u03a0\u039f\u03a5. \u03a3\u03c4\u03b7 \u03bc\u03b5\u03bd \u03c0\u03c1\u03ce\u03c4\u03b7 \u03c0\u03bf\u03bb\u03c5\u03ba\u03b5\u03bd\u03c4\u03c1\u03b9\u03ba\u03ae \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7, \u03c3\u03b5 271 \u03ac\u03bd\u03b4\u03c1\u03b5\u03c2 \u0391\u03c3\u03b9\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2 \u03ba\u03b1\u03b9 \u039a\u03b1\u03c5\u03ba\u03ac\u03c3\u03b9\u03b1\u03c2 \u03c0\u03c1\u03bf\u03ad\u03bb\u03b5\u03c5\u03c3\u03b7\u03c2 \u03c7\u03bf\u03c1\u03b7\u03b3\u03ae\u03b8\u03b7\u03ba\u03b1\u03bd 200mg TE \u03bc\u03b5 \u03b5\u03b2\u03b4\u03bf\u03bc\u03b1\u03b4\u03b9\u03b1\u03af\u03b1 \u03ad\u03bd\u03b5\u03c3\u03b7 \u03b5\u03c0\u03af 6 \u03bc\u03ae\u03bd\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03bf 70% \u03c4\u03c9\u03bd \u03b1\u03bd\u03b4\u03c1\u03ce\u03bd \u03b5\u03c0\u03b9\u03c4\u03b5\u03cd\u03c7\u03b8\u03b7\u03ba\u03b5 \u03b1\u03b6\u03c9\u03bf\u03c3\u03c0\u03b5\u03c1\u03bc\u03af\u03b1. \u03a3\u03c4\u03b7 \u03c6\u03ac\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7\u03c2 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2, \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03b4\u03b9\u03ae\u03c1\u03ba\u03b7\u03c3\u03b5 \u03ad\u03bd\u03b1 \u03ad\u03c4\u03bf\u03c2 \u03b5\u03c0\u03b9\u03bb\u03ad\u03c7\u03b8\u03b7\u03c3\u03b1\u03bd \u03bd\u03b1 \u03b5\u03b9\u03c3\u03b1\u03c7\u03b8\u03bf\u03cd\u03bd \u03bc\u03cc\u03bd\u03bf \u03bf\u03b9 \u03b1\u03b6\u03c9\u03bf\u03c3\u03c0\u03b5\u03c1\u03bc\u03b9\u03ba\u03bf\u03af \u03ac\u03bd\u03b4\u03c1\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03ae\u03c4\u03b1\u03bd \u03bc\u03af\u03b1 \u03bc\u03cc\u03bd\u03bf \u03b5\u03b3\u03ba\u03c5\u03bc\u03bf\u03c3\u03cd\u03bd\u03b7 (1\/157 \u03ac\u03bd\u03b4\u03c1\u03b5\u03c2).<sup>29<\/sup> \u03a3\u03c4\u03b7 \u03b4\u03b5\u03cd\u03c4\u03b5\u03c1\u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03c4\u03bf\u03c5 \u03a0\u039f\u03a5 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03b5\u03af\u03c7\u03b1\u03bd 357 \u03b6\u03b5\u03c5\u03b3\u03ac\u03c1\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03ac\u03bd\u03b4\u03c1\u03b5\u03c2 \u03c7\u03bf\u03c1\u03b7\u03b3\u03ae\u03b8\u03b7\u03c3\u03b1\u03bd \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 200mg \u03a4\u0395 \u03b5\u03b2\u03b4\u03bf\u03bc\u03b1\u03b4\u03b9\u03b1\u03af\u03c9\u03c2.<sup>30<\/sup> \u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03b5\u03ba\u03c4\u03cc\u03c2 \u03c4\u03c9\u03bd \u03b1\u03b6\u03c9\u03bf\u03c3\u03c0\u03b5\u03c1\u03bc\u03b9\u03ba\u03ce\u03bd \u03c3\u03c4\u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03b5\u03bb\u03ae\u03c6\u03b8\u03b7\u03c3\u03b1\u03bd \u03ba\u03b1\u03b9 \u03ac\u03bd\u03b4\u03c1\u03b5\u03c2 \u03bc\u03b5 \u03c3\u03bf\u03b2\u03b1\u03c1\u03ae \u03bf\u03bb\u03b9\u03b3\u03bf\u03b6\u03c9\u03bf\u03c3\u03c0\u03b5\u03c1\u03bc\u03af\u03b1 (&lt;3 \u03b5\u03ba\u03b1\u03c4\u03bf\u03bc\u03bc\u03cd\u03c1\u03b9\u03b1 \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b6\u03c9\u03ac\u03c1\u03b9\u03b1 \/ ml), \u03bf\u03b9 \u03bf\u03c0\u03bf\u03af\u03bf\u03b9 \u03ae\u03c4\u03b1\u03bd \u03ba\u03b1\u03b9 \u03c4\u03bf 98% \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bd\u03cc\u03bb\u03bf\u03c5. \u03a3\u03c4\u03bf\u03c5\u03c2 \u03bf\u03bb\u03b9\u03b3\u03bf\u03b6\u03c9\u03bf\u03c3\u03c0\u03b5\u03c1\u03bc\u03b9\u03ba\u03bf\u03cd\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03c4\u03b1 \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03ac \u03b1\u03c0\u03bf\u03c4\u03c5\u03c7\u03af\u03b1\u03c2 \u03ae\u03c4\u03b1\u03bd \u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b1 \u03b1\u03c0\u03cc \u03b1\u03c5\u03c4\u03ac \u03c4\u03c9\u03bd \u03b1\u03b6\u03c9\u03bf\u03c3\u03c0\u03b5\u03c1\u03bc\u03b9\u03ba\u03ce\u03bd, \u03b1\u03bb\u03bb\u03ac \u03c3\u03b1\u03c6\u03ce\u03c2 \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b1 \u03b1\u03c0\u03cc \u03cc\u03c4\u03b9 \u03bc\u03b5 \u03c4\u03b7 \u03c7\u03c1\u03ae\u03c3\u03b7 \u03c0\u03c1\u03bf\u03c6\u03c5\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03bf\u03cd. \u0391\u03bd\u03c4\u03b9\u03b8\u03ad\u03c4\u03c9\u03c2, \u03b1\u03c1\u03b9\u03b8\u03bc\u03cc\u03c2 \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b6\u03c9\u03b1\u03c1\u03af\u03c9\u03bd &gt; 3 \u03b5\u03ba\u03b1\u03c4\u03bf\u03bc\u03bc\u03cd\u03c1\u03b9\u03b1 \/ ml \u03c3\u03c5\u03c3\u03c7\u03b5\u03c4\u03af\u03c3\u03c4\u03b7\u03ba\u03b5 \u03bc\u03b5 \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03ac \u03b1\u03c0\u03bf\u03c4\u03c5\u03c7\u03af\u03b1\u03c2 \u03b5\u03c6\u03ac\u03bc\u03b9\u03bb\u03bb\u03b1 \u03c4\u03b7\u03c2 \u03c7\u03c1\u03ae\u03c3\u03b7\u03c2 \u03c0\u03c1\u03bf\u03c6\u03c5\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03bf\u03cd. \u039c\u03b5\u03b9\u03bf\u03bd\u03ad\u03ba\u03c4\u03b7\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b9\u03c2 \u03b4\u03cd\u03bf \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03b5 \u03b7 \u03ad\u03bb\u03bb\u03b5\u03b9\u03c8\u03b7 \u03c0\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2, \u03ba\u03b1\u03b8\u03ce\u03c2 \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af\u03c4\u03bf \u03b7 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03b5\u03bd\u03b4\u03bf\u03bc\u03c5\u03ca\u03ba\u03ce\u03bd \u03b5\u03bd\u03ad\u03c3\u03b5\u03c9\u03bd \u03c3\u03b5 \u03b5\u03b2\u03b4\u03bf\u03bc\u03b1\u03b4\u03b9\u03b1\u03af\u03b1 \u03b2\u03ac\u03c3\u03b7, \u03ba\u03b1\u03b8\u03ce\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03bf \u03bc\u03b5\u03b3\u03ac\u03bb\u03bf \u03b4\u03b9\u03ac\u03c3\u03c4\u03b7\u03bc\u03b1 \u03c0\u03bf\u03c5 \u03b1\u03c0\u03b1\u03b9\u03c4\u03ae\u03b8\u03b7\u03ba\u03b5 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b9\u03ba\u03b1\u03bd\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03ae \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03b7\u03c2 \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7\u03c2.<\/p>\n<h6 style=\"text-align: justify;\">3.2.2. \u0395\u03bd\u03b4\u03b5\u03ba\u03b1\u03bd\u03bf\u03ca\u03ba\u03ae \u03c4\u03b5\u03c3\u03c4\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7<\/h6>\n<p style=\"text-align: justify;\">\u0397 \u03c0\u03c1\u03ce\u03c4\u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03c6\u03ac\u03c3\u03b7\u03c2 \u0399\u0399\u0399 \u03bc\u03b5 \u03b5\u03bd\u03b4\u03b5\u03ba\u03b1\u03bd\u03bf\u03ca\u03ba\u03ae \u03c4\u03b5\u03c3\u03c4\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7 (TU) \u03b1\u03c6\u03bf\u03c1\u03bf\u03cd\u03c3\u03b5 305 \u03ac\u03bd\u03b4\u03c1\u03b5\u03c2 \u03ba\u03b9\u03bd\u03b5\u03b6\u03b9\u03ba\u03ae\u03c2 \u03b5\u03b8\u03bd\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2, \u03c3\u03c4\u03bf\u03c5\u03c2 \u03bf\u03c0\u03bf\u03af\u03bf\u03c5\u03c2 \u03c7\u03bf\u03c1\u03b7\u03b3\u03ae\u03b8\u03b7\u03ba\u03b5 TU \u03b4\u03b9\u03b1\u03bb\u03c5\u03bc\u03ad\u03bd\u03b7 \u03c3\u03b5 \u03ad\u03bb\u03b1\u03b9\u03bf \u03b1\u03c0\u03cc \u03c3\u03c0\u03ac\u03c1\u03bf\u03c5\u03c2 \u03c4\u03c3\u03b1\u03b3\u03b9\u03bf\u03cd, \u03c3\u03b5 \u03bc\u03b7\u03bd\u03b9\u03b1\u03af\u03b5\u03c2 \u03b5\u03bd\u03b4\u03bf\u03bc\u03c5\u03ca\u03ba\u03ad\u03c2 \u03b5\u03bd\u03ad\u03c3\u03b5\u03b9\u03c2 \u03c4\u03c9\u03bd 500 mg TU \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u03bc\u03af\u03b1 \u03b4\u03cc\u03c3\u03b7 \u03c6\u03cc\u03c1\u03c4\u03b9\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd 1000 mg.<sup>31<\/sup> \u03a3\u03c4\u03b7 12\u03bc\u03b7\u03bd\u03b7 \u03c6\u03ac\u03c3\u03b7 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03b5\u03b9\u03c3\u03ae\u03bb\u03b8\u03b1\u03bd 296 \u03ac\u03bd\u03b4\u03c1\u03b5\u03c2 (97%), \u03c3\u03c4\u03bf\u03c5\u03c2 \u03bf\u03c0\u03bf\u03af\u03bf\u03c5\u03c2 \u03b5\u03c0\u03b9\u03c4\u03b5\u03cd\u03c7\u03b8\u03b7\u03ba\u03b5 \u03c3\u03bf\u03b2\u03b1\u03c1\u03ae \u03bf\u03bb\u03b9\u03b3\u03bf\u03b6\u03c9\u03bf\u03c3\u03c0\u03b5\u03c1\u03bc\u03af\u03b1 (&lt; 3 \u03b5\u03ba\u03b1\u03c4\u03bf\u03bc\u03bc\u03cd\u03c1\u03b9\u03b1 \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b6\u03c9\u03ac\u03c1\u03b9\u03b1\/ml). \u03a3\u03b5 \u03ad\u03be\u03b9 \u03ac\u03bd\u03b4\u03c1\u03b5\u03c2 \u03b5\u03be \u03b1\u03c5\u03c4\u03ce\u03bd \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03ae\u03b8\u03b7\u03ba\u03b5 \u03b5\u03c0\u03b1\u03bd\u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7 \u03c3\u03c0\u03ad\u03c1\u03bc\u03b1\u03c4\u03bf\u03c2, \u03c3\u03c4\u03b7\u03bd \u03bf\u03c0\u03bf\u03af\u03b1 \u03b1\u03c0\u03bf\u03b4\u03cc\u03b8\u03b7\u03ba\u03b5 \u03bc\u03af\u03b1 \u03b5\u03b3\u03ba\u03c5\u03bc\u03bf\u03c3\u03cd\u03bd\u03b7 (\u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03b1\u03bd\u03c4\u03b9\u03c3\u03c5\u03bb\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 96.,7%). \u0391\u03b9\u03c4\u03af\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b5\u03c0\u03b1\u03bd\u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c3\u03c0\u03ad\u03c1\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03ae\u03c4\u03b1\u03bd \u03bf\u03b9 \u03c5\u03c8\u03b7\u03bb\u03ad\u03c2 \u03b1\u03b9\u03c7\u03bc\u03ad\u03c2 \u03c4\u03c9\u03bd \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03bf\u03cd\u03bd\u03c4\u03c9\u03bd \u03b5\u03c0\u03b9\u03c0\u03ad\u03b4\u03c9\u03bd \u03c4\u03b5\u03c3\u03c4\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7\u03c2 \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u03ba\u03ac\u03b8\u03b5 \u03b5\u03bd\u03ad\u03c3\u03b9\u03bc\u03b7 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7.<sup>27<\/sup> \u0391\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b5 \u03bc\u03af\u03b1 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2, \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03c3\u03c4\u03b7\u03bd \u039a\u03af\u03bd\u03b1, \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7\u03bd \u03bf\u03c0\u03bf\u03af\u03b1 \u03c7\u03bf\u03c1\u03b7\u03b3\u03ae\u03b8\u03b7\u03ba\u03b1\u03bd 500 mg TU \u03b5\u03bd\u03b4\u03bf\u03bc\u03c5\u03ca\u03ba\u03ac \u03c3\u03b5 1000 \u03ac\u03bd\u03b4\u03c1\u03b5\u03c2 \u03c3\u03b5 \u03bc\u03b7\u03bd\u03b9\u03b1\u03af\u03b1 \u03b2\u03ac\u03c3\u03b7.<sup>32<\/sup> \u03a3\u03c4\u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03b1\u03c5\u03c4\u03ae, 855 \u03ac\u03bd\u03b4\u03c1\u03b5\u03c2 \u03b5\u03b9\u03c3\u03ae\u03bb\u03b8\u03b1\u03bd \u03c3\u03c4\u03b7 \u03c6\u03ac\u03c3\u03b7 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2, \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7 \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 \u03bf\u03c0\u03bf\u03af\u03b1\u03c2 \u03ba\u03b1\u03c4\u03b1\u03b3\u03c1\u03ac\u03c6\u03b7\u03ba\u03b1\u03bd \u03b5\u03bd\u03bd\u03ad\u03b1 \u03b5\u03b3\u03ba\u03c5\u03bc\u03bf\u03c3\u03cd\u03bd\u03b5\u03c2. \u03a4\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03b1\u03c5\u03c4\u03ac \u03b1\u03bd\u03c4\u03b9\u03c3\u03c4\u03bf\u03b9\u03c7\u03bf\u03cd\u03bd \u03c3\u03b5 \u03b4\u03b5\u03af\u03ba\u03c4\u03b7 Pearl 1,1% \u03b1\u03bd\u03ac \u03ad\u03c4\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03c6\u03ac\u03bc\u03b9\u03bb\u03bb\u03b1 \u03c4\u03b7\u03c2 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c4\u03c9\u03bd \u03b3\u03c5\u03bd\u03b1\u03b9\u03ba\u03b5\u03af\u03c9\u03bd \u03b1\u03bd\u03c4\u03b9\u03c3\u03c5\u03bb\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03ce\u03bd.<\/p>\n<p style=\"text-align: justify;\">\u03a3\u03c4\u03b7\u03bd \u0395\u03c5\u03c1\u03ce\u03c0\u03b7 \u03b7 TU \u03c0\u03b1\u03c1\u03b1\u03c3\u03ba\u03b5\u03c5\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b4\u03b9\u03b1\u03bb\u03c5\u03bc\u03ad\u03bd\u03b7 \u03c3\u03b5 \u03ba\u03b1\u03c3\u03c4\u03bf\u03c1\u03ad\u03bb\u03b1\u03b9\u03bf, \u03b3\u03b5\u03b3\u03bf\u03bd\u03cc\u03c2 \u03c0\u03bf\u03c5 \u03c4\u03b7\u03c2 \u03b4\u03af\u03bd\u03b5\u03b9 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03b2\u03b9\u03bf\u03b4\u03b9\u03b1\u03b8\u03b5\u03c3\u03b9\u03bc\u03cc\u03c4\u03b7\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03b5\u03c0\u03b9\u03c4\u03c1\u03ad\u03c0\u03b5\u03b9 \u03c4\u03b7 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03b1\u03bd\u03ac 12 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2. \u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 TU \u03c3\u03b5 \u039a\u03b1\u03c5\u03ba\u03ac\u03c3\u03b9\u03bf\u03c5\u03c2 \u03ac\u03bd\u03b4\u03c1\u03b5\u03c2 \u03b1\u03bd\u03ac 6 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03c0\u03c1\u03bf\u03ba\u03ac\u03bb\u03b5\u03c3\u03b5 \u03b1\u03b6\u03c9\u03bf\u03c3\u03c0\u03b5\u03c1\u03bc\u03af\u03b1 \u03bc\u03cc\u03bd\u03bf \u03c3\u03b5 \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc 60%, \u03b5\u03bd\u03ce \u03bc\u03b5\u03c4\u03b1\u03b3\u03b5\u03bd\u03ad\u03c3\u03c4\u03b5\u03c1\u03b5\u03c2 \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03bf\u03ba\u03b9\u03bd\u03b7\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c0\u03c1\u03cc\u03c4\u03b5\u03b9\u03bd\u03b1\u03bd \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b5\u03c0\u03af\u03c4\u03b5\u03c5\u03be\u03b7 \u03b5\u03c0\u03b9\u03c0\u03ad\u03b4\u03c9\u03bd \u03ba\u03b1\u03c4\u03ac\u03bb\u03bb\u03b7\u03bb\u03c9\u03bd \u03b3\u03b9\u03b1 \u03b1\u03bd\u03c4\u03b9\u03c3\u03cd\u03bb\u03bb\u03b7\u03c8\u03b7 \u03c4\u03b7\u00a0\u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03ae \u03c4\u03b7\u03c2 \u03b1\u03bd\u03ac 8 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2.<sup>33<\/sup> \u03a4\u03b1 \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03ac \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03c6\u03ac\u03bc\u03b9\u03bb\u03bb\u03b1 \u03c4\u03b7\u03c2 \u03a4\u0395 \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b1 \u03bc\u03b5\u03c3\u03bf\u03b4\u03b9\u03b1\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03b1 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03c4\u03c9\u03bd \u03c7\u03bf\u03c1\u03b7\u03b3\u03ae\u03c3\u03b5\u03c9\u03bd \u03ba\u03ac\u03bd\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ae \u03c4\u03b7\u03c2 TU \u03c0\u03b9\u03bf \u03b5\u03bb\u03ba\u03c5\u03c3\u03c4\u03b9\u03ba\u03ae. \u039c\u03b5\u03b9\u03bf\u03bd\u03ad\u03ba\u03c4\u03b7\u03bc\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03b7\u00a0\u03b4\u03b9\u03ac\u03bb\u03c5\u03c3\u03b9\u03c2 \u03c3\u03b5 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b7 \u03c0\u03bf\u03c3\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b5\u03ba\u03b4\u03cc\u03c7\u03bf\u03c5 (4 ml), \u03b3\u03b5\u03b3\u03bf\u03bd\u03cc\u03c2 \u03c4\u03bf \u03bf\u03c0\u03bf\u03af\u03bf \u03ba\u03ac\u03bd\u03b5\u03b9 \u03c4\u03b7 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03c0\u03b9\u03bf \u03b5\u03c0\u03ce\u03b4\u03c5\u03bd\u03b7. \u0395\u03c0\u03af\u03c3\u03b7\u03c2, \u03b7 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c3\u03b5 \u03ac\u03bd\u03b4\u03c1\u03b5\u03c2 \u03ba\u03b1\u03c5\u03ba\u03ac\u03c3\u03b9\u03b1\u03c2 \u03c6\u03c5\u03bb\u03ae\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03ba\u03c1\u03cc\u03c4\u03b5\u03c1\u03b7 \u03b1\u03c0\u03cc \u03cc\u03c4\u03b9 \u03c3\u03b5 \u03ac\u03bd\u03b4\u03c1\u03b5\u03c2 \u03ba\u03b9\u03bd\u03b5\u03b6\u03b9\u03ba\u03ae\u03c2 \u03c0\u03c1\u03bf\u03ad\u03bb\u03b5\u03c5\u03c3\u03b7\u03c2.<\/p>\n<h6 style=\"text-align: justify;\">3.2.3. \u0392\u03bf\u03c5\u03ba\u03c5\u03ba\u03bb\u03b9\u03ba\u03ae \u03c4\u03b5\u03c3\u03c4\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7<\/h6>\n<p style=\"text-align: justify;\">\u0397 \u03b2\u03bf\u03c5\u03ba\u03c5\u03ba\u03bb\u03b9\u03ba\u03ae \u03c4\u03b5\u03c3\u03c4\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7 (\u03a4\u0392) \u03c0\u03c1\u03bf\u03ad\u03ba\u03c5\u03c8\u03b5 \u03c3\u03c4\u03b7 \u03b4\u03b5\u03ba\u03b1\u03b5\u03c4\u03af\u03b1 \u03c4\u03bf\u03c5 1970 \u03c9\u03c2 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c3\u03c5\u03bd\u03b5\u03c1\u03b3\u03b1\u03c3\u03af\u03b1\u03c2 \u03c4\u03bf\u03c5 \u03a0\u039f\u03a5 \u03bc\u03b5 \u03c4\u03bf NIH \u03c3\u03b5 \u03bc\u03af\u03b1 \u03c0\u03c1\u03bf\u03c3\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1 \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7\u03c2 \u03bc\u03af\u03b1\u03c2 \u03bc\u03bf\u03c1\u03c6\u03ae\u03c2 \u03c4\u03b5\u03c3\u03c4\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7\u03c2 \u03bc\u03b5 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b5\u03c4\u03b1\u03bc\u03ad\u03bd\u03bf \u03c7\u03c1\u03cc\u03bd\u03bf \u03b4\u03c1\u03ac\u03c3\u03b7\u03c2, \u03ce\u03c3\u03c4\u03b5 \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03ba\u03b1\u03bc\u03c6\u03b8\u03b5\u03af \u03b7 \u03b1\u03bd\u03ac\u03b3\u03ba\u03b7 \u03c3\u03c5\u03c7\u03bd\u03ae\u03c2 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7\u03c2. \u03a0\u03c1\u03cc\u03ba\u03b5\u03b9\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03b5\u03c3\u03c4\u03ad\u03c1\u03b1 \u03c4\u03b7\u03c2 \u03c4\u03b5\u03c3\u03c4\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7\u03c2 (17\u03b2-trans-4-n-\u03b2\u03bf\u03c5\u03c4\u03c5\u03bb-\u03ba\u03c5\u03ba\u03bb\u03bf\u03b5\u03be\u03c5\u03bb\u03ba\u03b1\u03c1\u03b2\u03bf\u03be\u03c5\u03bb\u03b9\u03ba\u03ae \u03c4\u03b5\u03c3\u03c4\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7) \u03bc\u03b5 \u03c7\u03c1\u03cc\u03bd\u03bf \u03b7\u03bc\u03b9\u03b6\u03c9\u03ae\u03c2 29,5 \u03b7\u03bc\u03b5\u03c1\u03ce\u03bd \u03c3\u03b5 \u03c3\u03c7\u03ad\u03c3\u03b7 \u03c4\u03b9\u03c2 4,5 \u03c4\u03b7\u03c2 \u03a4\u0395 \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03b4\u03c1\u03ac\u03c3\u03b7\u03c2 3-4 \u03bc\u03ae\u03bd\u03b5\u03c2.<sup>34<\/sup> \u0395\u03c6\u03ac\u03c0\u03b1\u03be \u03b5\u03bd\u03b4\u03bf\u03bc\u03c5\u03ca\u03ba\u03ae \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03a4\u0392 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03ad\u03c3\u03b5\u03b9 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03b7\u03c2 \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7\u03c2 \u03c3\u03c5\u03b3\u03ba\u03c1\u03af\u03c3\u03b9\u03bc\u03b7 \u03bc\u03b5 \u03b5\u03ba\u03b5\u03af\u03bd\u03b7 \u03c4\u03c9\u03bd \u03b5\u03b2\u03b4\u03bf\u03bc\u03b1\u03b4\u03b9\u03b1\u03af\u03c9\u03bd \u03b5\u03bd\u03ad\u03c3\u03b5\u03c9\u03bd \u03a4\u0395,<sup>35<\/sup> \u03c9\u03c3\u03c4\u03cc\u03c3\u03bf \u03b4\u03b5\u03bd \u03ad\u03c7\u03b5\u03b9 \u03c0\u03c1\u03bf\u03ba\u03cd\u03c8\u03b5\u03b9 \u03ad\u03c9\u03c2 \u03c4\u03ce\u03c1\u03b1 \u03b5\u03bd\u03b4\u03b9\u03b1\u03c6\u03ad\u03c1\u03bf\u03bd \u03b3\u03b9\u03b1 \u03b5\u03bc\u03c0\u03bf\u03c1\u03b9\u03ba\u03ae \u03b5\u03ba\u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b5\u03c5\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ae\u03c2 \u03bf\u03c5\u03c3\u03af\u03b1\u03c2.<\/p>\n<h6 style=\"text-align: justify;\">3.2.4. \u0395\u03bc\u03c6\u03c5\u03c4\u03b5\u03cd\u03bc\u03b1\u03c4\u03b1 \u03c4\u03b5\u03c3\u03c4\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7\u03c2<\/h6>\n<p style=\"text-align: justify;\">\u0397 \u03b5\u03c0\u03b1\u03bd\u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7 \u03c3\u03c0\u03ad\u03c1\u03bc\u03b1\u03c4\u03bf\u03c2 (sperm rebound) \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7\u03bd \u03b1\u03bd\u03c4\u03b9\u03c3\u03c5\u03bb\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03ae \u03b1\u03b3\u03c9\u03b3\u03ae \u03bc\u03b5 \u03b5\u03bd\u03ad\u03c3\u03b9\u03bc\u03b1 \u03c3\u03ba\u03b5\u03c5\u03ac\u03c3\u03bc\u03b1\u03c4\u03b1 \u03c4\u03b5\u03c3\u03c4\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7\u03c2 \u03c9\u03c2 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03c9\u03bd \u03b1\u03b9\u03c7\u03bc\u03ce\u03bd \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7, \u03c4\u03cc\u03bd\u03b9\u03c3\u03b5 \u03c4\u03b7\u03bd \u03b1\u03bd\u03ac\u03b3\u03ba\u03b7 \u03b5\u03c6\u03b1\u03c1\u03bc\u03bf\u03b3\u03ae\u03c2 \u03c4\u03b7\u03c2 \u03c4\u03b5\u03c3\u03c4\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7\u03c2 \u03c3\u03b5 \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03bf\u03c4\u03b5\u03c7\u03bd\u03b9\u03ba\u03ad\u03c2 \u03bc\u03bf\u03c1\u03c6\u03ad\u03c2 \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03ae\u03c2 \u03c0\u03b1\u03c1\u03bf\u03c7\u03ae\u03c2. \u03a4\u03ad\u03c4\u03bf\u03b9\u03b5\u03c2 \u03bc\u03bf\u03c1\u03c6\u03ad\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03b1 \u03b5\u03bc\u03c6\u03c5\u03c4\u03b5\u03cd\u03bc\u03b1\u03c4\u03b1 \u03c4\u03b5\u03c3\u03c4\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7\u03c2, \u03c4\u03b1 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c4\u03bf\u03c0\u03bf\u03b8\u03b5\u03c4\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c1\u03af\u03c9\u03c2 \u03ba\u03b1\u03b9 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03c0\u03b1\u03c1\u03ad\u03c7\u03bf\u03c5\u03bd \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03ac \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03b5\u03c3\u03c4\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7\u03c2 \u03c3\u03c4\u03b7\u03bd \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03af\u03b1 \u03b3\u03b9\u03b1 \u03c0\u03bf\u03bb\u03bb\u03bf\u03cd\u03c2 \u03bc\u03ae\u03bd\u03b5\u03c2. \u0397 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03ac \u03b5\u03c6\u03ac\u03c0\u03b1\u03be \u03c4\u03bf\u03c0\u03bf\u03b8\u03ad\u03c4\u03b7\u03c3\u03b7\u03c2 \u03b5\u03bc\u03c6\u03c5\u03c4\u03b5\u03c5\u03bc\u03ac\u03c4\u03c9\u03bd \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae\u03c2 \u03b4\u03cc\u03c3\u03b7\u03c2 1200mg \u03ae\u03c4\u03b1\u03bd \u03b5\u03c6\u03ac\u03bc\u03b9\u03bb\u03bb\u03b7 \u03bc\u03b5 \u03b1\u03c5\u03c4\u03ae \u03c4\u03b7\u03c2 \u03b5\u03b2\u03b4\u03bf\u03bc\u03b1\u03b4\u03b9\u03b1\u03af\u03b1\u03c2 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7\u03c2 \u03a4\u0395 \u03ba\u03b1\u03b9 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03c4\u03bf\u03cd\u03bd \u03bc\u03b5 \u03c0\u03c1\u03bf\u03b3\u03b5\u03c3\u03c4\u03b1\u03b3\u03cc\u03bd\u03b1 \u03b3\u03b9\u03b1 \u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b7 \u03b1\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1.<sup>36<\/sup> \u0397 \u03c4\u03bf\u03c0\u03bf\u03b8\u03ad\u03c4\u03b7\u03c3\u03ae \u03c4\u03bf\u03c5\u03c2 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b5\u03be\u03c9\u03c4\u03b5\u03c1\u03b9\u03ba\u03cc \u03b9\u03b1\u03c4\u03c1\u03b5\u03af\u03bf \u03bc\u03b5 \u03bc\u03b9\u03ba\u03c1\u03ae \u03c4\u03bf\u03bc\u03ae \u03c3\u03c4\u03bf \u03b4\u03ad\u03c1\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b3\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03bd\u03c4\u03b9\u03bb\u03b7\u03c0\u03c4\u03ac \u03bc\u03b5 \u03c4\u03b7\u03bd \u03c8\u03b7\u03bb\u03ac\u03c6\u03b7\u03c3\u03b7, \u03b3\u03b5\u03b3\u03bf\u03bd\u03cc\u03c2 \u03c0\u03bf\u03c5 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03ba\u03b1\u03b9 \u03b4\u03b9\u03b1\u03b2\u03b5\u03b2\u03b1\u03af\u03c9\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03c3\u03cd\u03bd\u03c4\u03c1\u03bf\u03c6\u03bf \u03cc\u03c4\u03b9 \u03bf \u03ac\u03bd\u03b4\u03c1\u03b1\u03c2 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03b1\u03bd\u03c4\u03b9\u03c3\u03c5\u03bb\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03ae \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf. \u039c\u03b5\u03b9\u03bf\u03bd\u03ad\u03ba\u03c4\u03b7\u03bc\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03b7 \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b1\u03c5\u03c4\u03cc\u03bc\u03b1\u03c4\u03b7\u03c2 \u03b1\u03c0\u03cc\u03c1\u03c1\u03b9\u03c8\u03b7\u03c2 \u03bc\u03b5 \u03b4\u03b9\u03ac\u03c3\u03c0\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c5\u03c0\u03b5\u03c1\u03ba\u03b5\u03b9\u03bc\u03ad\u03bd\u03bf\u03c5 \u03b4\u03ad\u03c1\u03bc\u03b1\u03c4\u03bf\u03c2, \u03b5\u03c0\u03b9\u03c0\u03bb\u03bf\u03ba\u03ae \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c3\u03c5\u03bc\u03b2\u03b1\u03af\u03bd\u03b5\u03b9 \u03c3\u03b5 \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc 3 &#8211; 7% \u03c4\u03c9\u03bd \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03c9\u03bd.<sup>37<\/sup><\/p>\n<h6 style=\"text-align: justify;\">3.2.5. \u0391\u03c0\u03cc \u03c4\u03bf\u03c5 \u03c3\u03c4\u03cc\u03bc\u03b1\u03c4\u03bf\u03c2 &#8211; \u03b4\u03b9\u03b1\u03b4\u03b5\u03c1\u03bc\u03b9\u03ba\u03ae \u03c4\u03b5\u03c3\u03c4\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7<\/h6>\n<p style=\"text-align: justify;\">\u0397 \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5 \u03c3\u03c4\u03cc\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c4\u03b5\u03c3\u03c4\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7\u03c2 \u03b4\u03b5\u03bd \u03b1\u03c0\u03b5\u03b4\u03b5\u03af\u03c7\u03b8\u03b7 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c9\u03c2 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf\u03c2 \u03b1\u03bd\u03b4\u03c1\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03c4\u03b9\u03c3\u03cd\u03bb\u03bb\u03b7\u03c8\u03b7, \u03ba\u03b1\u03b8\u03ce\u03c2 \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03b5\u03c3\u03c4\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7\u03c2 \u03c0\u03bf\u03c5 \u03b5\u03c0\u03b9\u03c4\u03c5\u03b3\u03c7\u03ac\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03af\u03b1 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03ac \u03bf\u03cd\u03c4\u03b5 \u03b5\u03c0\u03b1\u03c1\u03ba\u03ae \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03c0\u03bb\u03ae\u03c1\u03b7 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03b7\u03c2 \u03ad\u03ba\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2 \u03b3\u03bf\u03bd\u03b1\u03b4\u03bf\u03c4\u03c1\u03bf\u03c0\u03b9\u03bd\u03ce\u03bd \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03c5\u03c0\u03cc\u03c6\u03c5\u03c3\u03b7. \u03a7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5 \u03c3\u03c4\u03cc\u03bc\u03b1\u03c4\u03bf\u03c2 240 mg TU \u03ac\u03c0\u03b1\u03be \u03b7\u03bc\u03b5\u03c1\u03b7\u03c3\u03af\u03c9\u03c2 \u03b5\u03c0\u03af 12 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03b5\u03af\u03c7\u03b5 \u03c9\u03c2 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b5\u03c0\u03b1\u03c1\u03ba\u03ae \u03b1\u03bd\u03c4\u03b9\u03c3\u03c5\u03bb\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03ae \u03b4\u03c1\u03ac\u03c3\u03b7 \u03bc\u03cc\u03bd\u03bf \u03c3\u03b5 1 \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5\u03c2 7 \u03b5\u03b8\u03b5\u03bb\u03bf\u03bd\u03c4\u03ad\u03c2, \u03b3\u03b5\u03b3\u03bf\u03bd\u03cc\u03c2 \u03c4\u03bf \u03bf\u03c0\u03bf\u03af\u03bf \u03b1\u03c1\u03c7\u03b9\u03ba\u03ac \u03b1\u03c0\u03bf\u03b4\u03cc\u03b8\u03b7\u03ba\u03b5 \u03c3\u03c4\u03bf \u03c3\u03cd\u03bd\u03c4\u03bf\u03bc\u03bf \u03c7\u03c1\u03cc\u03bd\u03bf \u03b4\u03c1\u03ac\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 TU \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5 \u03c3\u03c4\u03cc\u03bc\u03b1\u03c4\u03bf\u03c2 \u03bb\u03cc\u03b3\u03c9 \u03c4\u03bf\u03c5 \u03b7\u03c0\u03b1\u03c4\u03b9\u03ba\u03bf\u03cd \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03c3\u03bc\u03bf\u03cd \u03c4\u03b7\u03c2. \u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03c0\u03c1\u03bf\u03ad\u03ba\u03c5\u03c8\u03b1\u03bd \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03c0\u03b9\u03bf \u03c3\u03c5\u03c7\u03bd\u03ae \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7, \u03b1\u03ba\u03cc\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b5\u03c4\u03c1\u03ac\u03ba\u03b9\u03c2 \u03b7\u03bc\u03b5\u03c1\u03b7\u03c3\u03af\u03c9\u03c2.<sup>38<\/sup> \u03a3\u03c4\u03b1\u03b8\u03b5\u03c1\u03cc\u03c4\u03b5\u03c1\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b5\u03c0\u03b9\u03c4\u03b5\u03c5\u03c7\u03b8\u03b5\u03af \u03bc\u03b5 \u03c3\u03c5\u03b3\u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03c4\u03b5\u03c3\u03c4\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03c9\u03bd \u03c4\u03b7\u03c2 5-\u03b1 \u03b1\u03bd\u03b1\u03b3\u03c9\u03b3\u03ac\u03c3\u03b7\u03c2 \u03c3\u03b5 \u03b5\u03bb\u03b1\u03b9\u03ce\u03b4\u03b5\u03c2 \u03b4\u03b9\u03ac\u03bb\u03c5\u03bc\u03b1.<sup>39<\/sup><\/p>\n<p style=\"text-align: justify;\">\u0397 \u03b4\u03b9\u03b1\u03b4\u03b5\u03c1\u03bc\u03b9\u03ba\u03ae \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03c4\u03b5\u03c3\u03c4\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b3\u03af\u03bd\u03b5\u03b9 \u03b5\u03af\u03c4\u03b5 \u03bc\u03b5 \u03c4\u03b7 \u03bc\u03bf\u03c1\u03c6\u03ae \u03b1\u03c5\u03c4\u03bf\u03ba\u03cc\u03bb\u03bb\u03b7\u03c4\u03c9\u03bd \u03b5\u03c0\u03b9\u03b8\u03b5\u03bc\u03ac\u03c4\u03c9\u03bd \u03b5\u03af\u03c4\u03b5 \u03bc\u03b5 \u03c4\u03b7 \u03bc\u03bf\u03c1\u03c6\u03ae \u03b3\u03ad\u03bb\u03b7\u03c2. \u03a4\u03b1 \u03b5\u03c0\u03b9\u03b8\u03ad\u03bc\u03b1\u03c4\u03b1 \u03b4\u03b5\u03bd \u03b5\u03af\u03c7\u03b1\u03bd \u03ba\u03b1\u03bb\u03ae \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c9\u03c2 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf\u03c2 \u03b1\u03bd\u03c4\u03b9\u03c3\u03cd\u03bb\u03bb\u03b7\u03c8\u03b7\u03c2 \u03bf\u03cd\u03c4\u03b5 \u03bc\u03b5\u03bc\u03bf\u03bd\u03c9\u03bc\u03ad\u03bd\u03b1 \u03bf\u03cd\u03c4\u03b5 \u03c3\u03b5 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc \u03bc\u03b5 \u03c0\u03c1\u03bf\u03b3\u03b5\u03c3\u03c4\u03b1\u03b3\u03cc\u03bd\u03b1, \u03b5\u03bd\u03ce \u03c0\u03b1\u03c1\u03ac\u03bb\u03bb\u03b7\u03bb\u03b1 \u03b4\u03b7\u03bc\u03b9\u03bf\u03c5\u03c1\u03b3\u03bf\u03cd\u03bd \u03c4\u03bf\u03c0\u03b9\u03ba\u03cc \u03b5\u03c1\u03b5\u03b8\u03b9\u03c3\u03bc\u03cc \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7\u03bd \u03b5\u03c6\u03b1\u03c1\u03bc\u03bf\u03b3\u03ae.<sup>40<\/sup> \u0391\u03bd\u03c4\u03af\u03b8\u03b5\u03c4\u03b1, \u03bf \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc\u03c2 \u03b3\u03ad\u03bb\u03b7\u03c2 \u03c4\u03b5\u03c3\u03c4\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7\u03c2 \u03bc\u03b5 \u03ad\u03bd\u03b1 \u03bc\u03b1\u03ba\u03c1\u03ac\u03c2 \u03b4\u03c1\u03ac\u03c3\u03b7\u03c2 \u03b5\u03bd\u03ad\u03c3\u03b9\u03bc\u03bf \u03c0\u03c1\u03bf\u03b3\u03b5\u03c3\u03c4\u03b1\u03b3\u03cc\u03bd\u03bf (depot \u03bc\u03b5\u03b4\u03c1\u03bf\u03be\u03c5-\u03c0\u03c1\u03bf\u03b3\u03b5\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7, DMPA), \u03bf\u03b4\u03ae\u03b3\u03b7\u03c3\u03b5 \u03c3\u03b5 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03b7\u03c2 \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7\u03c2 \u03c3\u03c5\u03b3\u03ba\u03c1\u03af\u03c3\u03b9\u03bc\u03b7 \u03bc\u03b5 \u03b1\u03c5\u03c4\u03ae\u03bd \u03c4\u03b7\u03c2 \u03b5\u03bd\u03b4\u03bf\u03bc\u03c5\u03ca\u03ba\u03ae\u03c2 \u03c4\u03b5\u03c3\u03c4\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7\u03c2.<sup>41<\/sup><\/p>\n<h6 style=\"text-align: justify;\">3.2.6. \u0391\u03bd\u03b5\u03c0\u03b9\u03b8\u03cd\u03bc\u03b7\u03c4\u03b5\u03c2 \u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2<\/h6>\n<p style=\"text-align: justify;\">\u03a4\u03bf \u03b3\u03b5\u03b3\u03bf\u03bd\u03cc\u03c2 \u03cc\u03c4\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b5\u03c0\u03af\u03c4\u03b5\u03c5\u03be\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03c0\u03b1\u03b9\u03c4\u03bf\u03cd\u03bc\u03b5\u03bd\u03b7\u03c2 \u03b3\u03b9\u03b1 \u03b1\u03bd\u03c4\u03b9\u03c3\u03cd\u03bb\u03bb\u03b7\u03c8\u03b7 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2 \u03c4\u03b7\u03c2 \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03b1\u03c1\u03b1\u03af\u03c4\u03b7\u03c4\u03b7 \u03b7 \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03af\u03b1 \u03c5\u03c0\u03b5\u03c1\u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ce\u03bd \u03b5\u03c0\u03b9\u03c0\u03ad\u03b4\u03c9\u03bd \u03c4\u03b5\u03c3\u03c4\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7\u03c2, \u03b4\u03b7\u03bc\u03b9\u03bf\u03cd\u03c1\u03b3\u03b7\u03c3\u03b5 \u03b1\u03bd\u03b7\u03c3\u03c5\u03c7\u03af\u03b1 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03ba\u03bf\u03b9\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b9\u03c2 \u03bc\u03b1\u03ba\u03c1\u03bf\u03c7\u03c1\u03cc\u03bd\u03b9\u03b5\u03c2 \u03b5\u03c0\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c4\u03b7\u03c2 \u03b1\u03bd\u03c4\u03b9\u03c3\u03c5\u03bb\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b1\u03b3\u03c9\u03b3\u03ae\u03c2 \u03c3\u03c4\u03b7\u03bd \u03c5\u03b3\u03b5\u03af\u03b1 \u03c4\u03c9\u03bd \u03b1\u03bd\u03b4\u03c1\u03ce\u03bd, \u03b9\u03b4\u03af\u03c9\u03c2 \u03c3\u03c4\u03bf \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03cc \u03c3\u03cd\u03c3\u03c4\u03b7\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03c3\u03c7\u03b5\u03c4\u03b9\u03b6\u03cc\u03bc\u03b5\u03bd\u03b7 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03c0\u03c1\u03bf\u03c3\u03c4\u03ac\u03c4\u03b7 \u03bd\u03bf\u03c3\u03b7\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1.<\/p>\n<p style=\"text-align: justify;\">\u039c\u03ad\u03c7\u03c1\u03b9 \u03c4\u03ce\u03c1\u03b1 \u03b4\u03b5\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1 \u03c0\u03bf\u03c5 \u03bd\u03b1 \u03c3\u03c5\u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03bf\u03c5\u03bd \u03ac\u03bc\u03b5\u03c3\u03b1 \u03c4\u03b7 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03b1\u03bd\u03b4\u03c1\u03bf\u03b3\u03cc\u03bd\u03c9\u03bd \u03bc\u03b5 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ae \u03bd\u03bf\u03c3\u03b7\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1, \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b5\u03be\u03b1\u03af\u03c1\u03b5\u03c3\u03b7 \u03bc\u03b9\u03b1\u03c2 \u03c0\u03c1\u03cc\u03c3\u03c6\u03b1\u03c4\u03b7\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7\u03c2 \u03c0\u03bf\u03c5 \u03b1\u03c6\u03bf\u03c1\u03bf\u03cd\u03c3\u03b5 \u03c4\u03b7 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03c4\u03b5\u03c3\u03c4\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7\u03c2 \u03c3\u03b5 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ac \u03b5\u03c0\u03b9\u03b2\u03b1\u03c1\u03c5\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03ba\u03b1\u03b9 \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03b7\u03b8\u03b5\u03af \u03ad\u03bd\u03c4\u03bf\u03bd\u03b1 \u03b3\u03b9\u03b1 \u03bc\u03b5\u03b8\u03bf\u03b4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03c0\u03c1\u03bf\u03b2\u03bb\u03ae\u03bc\u03b1\u03c4\u03b1.<sup>41<\/sup> \u0395\u03af\u03bd\u03b1\u03b9 \u03c0\u03ac\u03bd\u03c4\u03c9\u03c2 \u03b4\u03b9\u03b1\u03c0\u03b9\u03c3\u03c4\u03c9\u03bc\u03ad\u03bd\u03bf \u03cc\u03c4\u03b9 \u03b7 \u03b5\u03be\u03c9\u03b3\u03b5\u03bd\u03ae\u03c2 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03b1\u03bd\u03b4\u03c1\u03bf\u03b3\u03cc\u03bd\u03c9\u03bd \u03c3\u03b5 \u03bd\u03b5\u03b1\u03c1\u03bf\u03cd\u03c2 \u03c5\u03b3\u03b9\u03b5\u03af\u03c2 \u03ac\u03bd\u03b4\u03c1\u03b5\u03c2, \u03c3\u03c5\u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c3\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03bf\u03cd \u03b2\u03ac\u03c1\u03bf\u03c5\u03c2 \u03c0\u03bf\u03c5 \u03b1\u03c6\u03bf\u03c1\u03ac \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c4\u03b7\u03bd \u03b5\u03bb\u03b5\u03cd\u03b8\u03b5\u03c1\u03b7 \u03bb\u03af\u03c0\u03bf\u03c5\u03c2 \u03bc\u03ac\u03b6\u03b1 \u03c4\u03bf\u03c5 \u03c3\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c5\u03c8\u03b7\u03bb\u03ae\u03c2 \u03c0\u03c5\u03ba\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 (HDL) \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2.<sup>42<\/sup> \u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03c0\u03b1\u03c1\u03ac\u03bb\u03bb\u03b7\u03bb\u03b1 \u03bc\u03b5 \u03c4\u03b7\u03bd HDL \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03b7 \u03c3\u03c5\u03b3\u03ba\u03ad\u03bd\u03c4\u03c1\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae\u03c2 \u03ba\u03b1\u03b9 \u03c7\u03b1\u03bc\u03b7\u03bb\u03ae\u03c2 \u03c0\u03c5\u03ba\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 (LDL) \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03af\u03bd\u03b7\u03c2, \u03c3\u03c4\u03b7\u03bd \u03bf\u03c0\u03bf\u03af\u03b1 \u03b1\u03c0\u03bf\u03b4\u03af\u03b4\u03b5\u03c4\u03b1\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03b7 \u03b1\u03b8\u03b7\u03c1\u03bf\u03b3\u03cc\u03bd\u03bf\u03c2 \u03b4\u03c1\u03ac\u03c3\u03b7.<sup>8<\/sup><\/p>\n<p style=\"text-align: justify;\">\u038c\u03c3\u03bf\u03bd \u03b1\u03c6\u03bf\u03c1\u03ac \u03c4\u03b7 \u03bd\u03bf\u03c3\u03b7\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03bf\u03c5 \u03c0\u03c1\u03bf\u03c3\u03c4\u03ac\u03c4\u03b7, \u03c4\u03b1 \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1 \u03c0\u03bf\u03c5 \u03b1\u03c6\u03bf\u03c1\u03bf\u03cd\u03bd \u03c4\u03b7 \u03c3\u03c5\u03c3\u03c7\u03ad\u03c4\u03b9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c5\u03c8\u03b7\u03bb\u03ce\u03bd \u03b5\u03c0\u03b9\u03c0\u03ad\u03b4\u03c9\u03bd \u03c4\u03b5\u03c3\u03c4\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7\u03c2 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 \u03ba\u03b1\u03ba\u03bf\u03ae\u03b8\u03b5\u03b9\u03b1\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03bd\u03c4\u03b9\u03ba\u03c1\u03bf\u03c5\u03cc\u03bc\u03b5\u03bd\u03b1.<sup>43<\/sup> \u0395\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd, \u03bf\u03b9 \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03c3\u03b5\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03b1\u03bd\u03b4\u03c1\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03c4\u03b9\u03c3\u03cd\u03bb\u03bb\u03b7\u03c8\u03b7\u03c2 \u03b1\u03c6\u03bf\u03c1\u03bf\u03cd\u03bd \u03ba\u03b1\u03c4\u03ac \u03ba\u03b1\u03bd\u03cc\u03bd\u03b1 \u03bd\u03b5\u03b1\u03c1\u03cc \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03cc \u03ba\u03b1\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03ba\u03c1\u03ae\u03c2 \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1\u03c2 \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03b5\u03c0\u03b9\u03c4\u03c1\u03ad\u03c8\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03b5\u03be\u03b1\u03b3\u03c9\u03b3\u03ae \u03b1\u03c3\u03c6\u03b1\u03bb\u03ce\u03bd \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b1\u03c3\u03bc\u03ac\u03c4\u03c9\u03bd. \u0394\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03bc\u03b1\u03b6\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c0\u03bf\u03c5 \u03b1\u03bd\u03b1\u03bc\u03ad\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03bb\u03ac\u03b2\u03b5\u03b9 \u03b7 \u03b5\u03bc\u03c0\u03bf\u03c1\u03b9\u03ba\u03ae \u03c7\u03c1\u03ae\u03c3\u03b7 \u03bc\u03af\u03b1\u03c2 \u03b1\u03bd\u03b4\u03c1\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03c4\u03b9\u03c3\u03c5\u03bb\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03ae\u03c2 \u03bc\u03b5\u03b8\u03cc\u03b4\u03bf\u03c5, \u03b7 \u03cd\u03c0\u03b1\u03c1\u03be\u03b7 \u03b1\u03bd\u03b1\u03c0\u03ac\u03bd\u03c4\u03b7\u03c4\u03c9\u03bd \u03b5\u03c1\u03c9\u03c4\u03b7\u03bc\u03ac\u03c4\u03c9\u03bd \u03b5\u03c0\u03b9\u03b2\u03ac\u03bb\u03bb\u03b5\u03b9 \u03c4\u03b7\u03bd \u03ba\u03b1\u03c4\u03ac \u03c4\u03bf \u03b4\u03c5\u03bd\u03b1\u03c4\u03cc \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b4\u03cc\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd \u03c7\u03bf\u03c1\u03b7\u03b3\u03bf\u03cd\u03bc\u03b5\u03bd\u03c9\u03bd \u03b1\u03bd\u03b4\u03c1\u03bf\u03b3\u03cc\u03bd\u03c9\u03bd \u03c3\u03c4\u03b7\u03bd \u03b5\u03bb\u03ac\u03c7\u03b9\u03c3\u03c4\u03b7 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b5\u03c0\u03af\u03c4\u03b5\u03c5\u03be\u03b7 \u03b1\u03bd\u03c4\u03b9\u03c3\u03cd\u03bb\u03bb\u03b7\u03c8\u03b7\u03c2.<sup>44<\/sup><\/p>\n<p style=\"text-align: justify;\">\u039c\u03b9\u03ba\u03c1\u03cc\u03c4\u03b5\u03c1\u03b7\u03c2 \u03b2\u03b1\u03c1\u03cd\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c0\u03b1\u03c1\u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7 \u03b1\u03ba\u03bc\u03ae\u03c2, \u03b5\u03bd\u03ce \u03b4\u03b5\u03bd \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b1\u03bb\u03bb\u03b1\u03b3\u03ad\u03c2. \u03a4\u03bf\u03c5\u03bd\u03b1\u03bd\u03c4\u03af\u03bf\u03bd, \u03b7 \u03c3\u03b5\u03be\u03bf\u03c5\u03b1\u03bb\u03b9\u03ba\u03ae \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03ba\u03b1\u03b9 \u03b9\u03ba\u03b1\u03bd\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b5\u03bb\u03b1\u03c6\u03c1\u03ce\u03c2.<sup>45<\/sup><\/p>\n<p style=\"text-align: justify;\">\u0395\u03c0\u03af\u03c3\u03b7\u03c2, \u03b5\u03c0\u03b9\u03c6\u03c5\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b5\u03ba\u03c6\u03c1\u03b1\u03c3\u03c4\u03b5\u03af \u03cc\u03c3\u03bf\u03bd \u03b1\u03c6\u03bf\u03c1\u03ac \u03c4\u03b7\u03bd \u03b1\u03bd\u03c4\u03b9\u03c3\u03c4\u03c1\u03b5\u03c8\u03b9\u03bc\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03b1\u03bd\u03c4\u03b9\u03c3\u03cd\u03bb\u03bb\u03b7\u03c8\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b7 \u03b4\u03c5\u03bd\u03b1\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b1\u03bd\u03ac\u03ba\u03b1\u03bc\u03c8\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7\u03c2 \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7 \u03bc\u03b1\u03ba\u03c1\u03bf\u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03bf\u03c1\u03bc\u03bf\u03bd\u03ce\u03bd. \u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03b7 \u03b4\u03c1\u03ac\u03c3\u03b7 \u03cc\u03bb\u03c9\u03bd \u03c4\u03c9\u03bd \u03b4\u03bf\u03ba\u03b9\u03bc\u03b1\u03c3\u03bc\u03ad\u03bd\u03c9\u03bd \u03c3\u03c7\u03b7\u03bc\u03ac\u03c4\u03c9\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03bb\u03ae\u03c1\u03c9\u03c2 \u03b1\u03bd\u03b1\u03c3\u03c4\u03c1\u03ad\u03c8\u03b9\u03bc\u03b7 \u03ba\u03b1\u03b9 \u03c9\u03c2 \u03c4\u03ce\u03c1\u03b1 \u03b4\u03b5\u03bd \u03ad\u03c7\u03b5\u03b9 \u03b1\u03bd\u03b1\u03c6\u03b5\u03c1\u03b8\u03b5\u03af \u03bc\u03cc\u03bd\u03b9\u03bc\u03b7 \u03c3\u03c4\u03b5\u03b9\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c3\u03b5 \u03ba\u03ac\u03c0\u03bf\u03b9\u03b1 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03c9\u03c2 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03b7\u03c2 \u03bf\u03c1\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03c4\u03b9\u03c3\u03c5\u03bb\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b1\u03b3\u03c9\u03b3\u03ae\u03c2. \u03a3\u03b5 \u03bc\u03af\u03b1 \u03c0\u03c1\u03cc\u03c3\u03c6\u03b1\u03c4\u03b7 \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b1\u03bd\u03b1\u03c3\u03ba\u03cc\u03c0\u03b7\u03c3\u03b7, \u03c3\u03c4\u03b7\u03bd \u03bf\u03c0\u03bf\u03af\u03b1 \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03b5\u03bb\u03ae\u03c6\u03b8\u03b7\u03c3\u03b1\u03bd 30 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03bc\u03b5 \u03ad\u03bd\u03b1 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03cc \u03b1\u03c1\u03b9\u03b8\u03bc\u03cc \u00a01549 \u03b1\u03bd\u03b4\u03c1\u03ce\u03bd, \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03ae\u03b8\u03b7\u03ba\u03b5 \u03b1\u03bd\u03ac\u03ba\u03b1\u03bc\u03c8\u03b7 \u03c4\u03b7\u03c2 \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7\u03c2 \u03c3\u03b5 \u03cc\u03bb\u03bf\u03c5\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03ad\u03c7\u03bf\u03bd\u03c4\u03b5\u03c2 \u03bc\u03b5 \u03bc\u03ad\u03c3\u03bf \u03c7\u03c1\u03cc\u03bd\u03bf \u03b1\u03c0\u03bf\u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5\u03c2 3-4 \u03bc\u03ae\u03bd\u03b5\u03c2.<sup>46<\/sup> \u03a9\u03c2 \u03c0\u03bb\u03ae\u03c1\u03b7\u03c2 \u03b1\u03c0\u03bf\u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7\u03c2 \u03bf\u03c1\u03af\u03c3\u03c4\u03b7\u03ba\u03b5 \u03bf \u03b1\u03c1\u03b9\u03b8\u03bc\u03cc\u03c2 \u03c4\u03c9\u03bd 20 \u03b5\u03ba\u03b1\u03c4\u03bf\u03bc\u03bc\u03c5\u03c1\u03af\u03c9\u03bd \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b6\u03c9\u03b1\u03c1\u03af\u03c9\u03bd\/ml, \u03c4\u03bf \u03cc\u03c1\u03b9\u03bf \u03c0\u03bf\u03c5 \u03b5\u03af\u03c7\u03b5 \u03c4\u03b5\u03b8\u03b5\u03af \u03c4\u03cc\u03c4\u03b5 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd \u03a0\u039f\u03a5 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b5\u03c0\u03af\u03c4\u03b5\u03c5\u03be\u03b7 \u03b3\u03bf\u03bd\u03b9\u03bc\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2. \u0397 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7\u03c2 \u03b1\u03bd\u03b4\u03c1\u03bf\u03b3\u03cc\u03bd\u03c9\u03bd \u03ba\u03b1\u03b9 \u03b7 \u03c7\u03c1\u03ae\u03c3\u03b7 \u03bc\u03bf\u03c1\u03c6\u03ce\u03bd \u03c0\u03b1\u03c1\u03b1\u03c4\u03b5\u03c4\u03b1\u03bc\u03ad\u03bd\u03b7\u03c2 \u03b4\u03c1\u03ac\u03c3\u03b7\u03c2 \u03c3\u03c7\u03b5\u03c4\u03af\u03c3\u03c4\u03b7\u03ba\u03b5 \u03bc\u03b5 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03bf \u03c7\u03c1\u03cc\u03bd\u03bf \u03b1\u03c0\u03bf\u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7\u03c2.<\/p>\n<h5 style=\"text-align: justify;\">3.4. \u03a3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc\u03c2 \u03b1\u03bd\u03b4\u03c1\u03bf\u03b3\u03cc\u03bd\u03c9\u03bd \u03bc\u03b5 GnRH \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 (\u0391\u03b3\u03c9\u03bd\u03b9\u03c3\u03c4\u03ad\u03c2 &#8211; \u0391\u03bd\u03c4\u03b1\u03b3\u03c9\u03bd\u03b9\u03c3\u03c4\u03ad\u03c2)<\/h5>\n<p style=\"text-align: justify;\">\u0397 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 GnRH \u03b1\u03b3\u03c9\u03bd\u03b9\u03c3\u03c4\u03ce\u03bd, \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u03bc\u03b9\u03b1 \u03b1\u03c1\u03c7\u03b9\u03ba\u03ae \u03c6\u03ac\u03c3\u03b7 \u03b4\u03b9\u03ad\u03b3\u03b5\u03c1\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd \u03b3\u03bf\u03bd\u03b1\u03b4\u03bf\u03c4\u03c1\u03bf\u03c0\u03b9\u03bd\u03ce\u03bd (flare up), \u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7 \u03c6\u03ac\u03c3\u03b7 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2 \u03bb\u03cc\u03b3\u03c9 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03c9\u03bd GnRH \u03c3\u03c4\u03b7\u03bd \u03c5\u03c0\u03cc\u03c6\u03c5\u03c3\u03b7 (down-regulation). \u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03c3\u03b5 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c3\u03c4\u03b9\u03c2 \u03bf\u03c0\u03bf\u03af\u03b5\u03c2 GnRH \u03b1\u03b3\u03c9\u03bd\u03b9\u03c3\u03c4\u03ad\u03c2 \u03c3\u03c5\u03b3\u03c7\u03bf\u03c1\u03b7\u03b3\u03ae\u03b8\u03b7\u03ba\u03b1\u03bd \u03bc\u03b5 \u03c4\u03b5\u03c3\u03c4\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7 \u03c9\u03c2 \u03bc\u03ad\u03c3\u03bf \u03b1\u03bd\u03b4\u03c1\u03b9\u03ba\u03ae\u03c2 \u03bf\u03c1\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03c4\u03b9\u03c3\u03cd\u03bb\u03bb\u03b7\u03c8\u03b7\u03c2, \u03b4\u03b5\u03bd \u03b5\u03c0\u03b9\u03c4\u03b5\u03cd\u03c7\u03b8\u03b7\u03ba\u03b5 \u03b5\u03c0\u03b1\u03c1\u03ba\u03ae\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03b7\u03c2 \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7\u03c2, \u03c0\u03c1\u03bf\u03c6\u03b1\u03bd\u03ce\u03c2 \u03bb\u03cc\u03b3\u03c9 \u03c4\u03b7\u03c2 \u03b1\u03b4\u03c5\u03bd\u03b1\u03bc\u03af\u03b1\u03c2 \u03c0\u03bb\u03ae\u03c1\u03bf\u03c5\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2 \u03c4\u03b7\u03c2 FSH.<sup>47<\/sup><\/p>\n<p style=\"text-align: justify;\">\u03a3\u03b5 \u03b1\u03bd\u03c4\u03af\u03b8\u03b5\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03bf\u03c5\u03c2 \u03b1\u03b3\u03c9\u03bd\u03b9\u03c3\u03c4\u03ad\u03c2, \u03bf\u03b9 GnRH \u03b1\u03bd\u03c4\u03b1\u03b3\u03c9\u03bd\u03b9\u03c3\u03c4\u03ad\u03c2 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03bf\u03cd\u03bd \u03c0\u03bb\u03b7\u03c1\u03ad\u03c3\u03c4\u03b5\u03c1\u03b7 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03cc\u03c3\u03bf \u03c4\u03b7\u03c2 LH \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 FSH, \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03bc\u03ac\u03bb\u03b9\u03c3\u03c4\u03b1 \u03b5\u03c0\u03b9\u03c4\u03c5\u03b3\u03c7\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03ad\u03c3\u03b1 \u03c3\u03b5 \u03bb\u03af\u03b3\u03b5\u03c2 \u03ce\u03c1\u03b5\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b7 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03b1\u03c0\u03bf\u03c6\u03b5\u03cd\u03b3\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03bf \u03c6\u03b1\u03b9\u03bd\u03cc\u03bc\u03b5\u03bd\u03bf \u03c4\u03bf\u03c5 flare up.<sup>47<\/sup> \u0388\u03c4\u03c3\u03b9, \u03c3\u03c5\u03b3\u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 GnRH \u03b1\u03bd\u03c4\u03b1\u03b3\u03c9\u03bd\u03b9\u03c3\u03c4\u03ae Nal \u2013 Glu \u03bc\u03b5 \u03a4\u0395 \u03b3\u03b9\u03b1 12 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af \u03b1\u03b6\u03c9\u03bf\u03c3\u03c0\u03b5\u03c1\u03bc\u03af\u03b1 \u03c3\u03c4\u03bf 88% \u03c4\u03c9\u03bd \u03b1\u03bd\u03b4\u03c1\u03ce\u03bd \u03ba\u03b1\u03b9 \u03c4\u03bf \u03b5\u03c5\u03bd\u03bf\u03ca\u03ba\u03cc \u03b1\u03c5\u03c4\u03cc \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c6\u03ac\u03bd\u03b7\u03ba\u03b5 \u03bd\u03b1 \u03b4\u03b9\u03b1\u03c4\u03b7\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03b5\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd 20 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03bc\u03bf\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03bc\u03b5 \u03a4\u0395.<sup>48<\/sup> \u0391\u03bd\u03c4\u03af\u03c3\u03c4\u03bf\u03b9\u03c7\u03b1, \u03c5\u03c8\u03b7\u03bb\u03ae \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03ae\u03b8\u03b7\u03ba\u03b5 \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7 \u03c3\u03c5\u03b3\u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03b1\u03bd\u03b4\u03c1\u03bf\u03b3\u03cc\u03bd\u03c9\u03bd \u03bc\u03b5 cetrorelix \u03ae abarelix \u03c3\u03b5 \u03b7\u03bc\u03b5\u03c1\u03ae\u03c3\u03b9\u03b1 \u03b5\u03bd\u03ad\u03c3\u03b9\u03bc\u03b7 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7,<sup>49<\/sup> \u03b5\u03bd\u03ce \u03bf \u03b1\u03bd\u03c4\u03b1\u03b3\u03c9\u03bd\u03b9\u03c3\u03c4\u03ae\u03c2 \u03b1\u03ba\u03c5\u03ba\u03bb\u03af\u03bd\u03b7 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03b5\u03af\u03bb\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03c4\u03b9\u03c2 \u03b3\u03bf\u03bd\u03b1\u03b4\u03bf\u03c4\u03c1\u03bf\u03c0\u03af\u03bd\u03b5\u03c2 \u03ad\u03c9\u03c2 \u03ba\u03b1\u03b9 2 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u03bc\u03af\u03b1 \u03b5\u03c6\u03ac\u03c0\u03b1\u03be \u03c5\u03c0\u03bf\u03b4\u03cc\u03c1\u03b9\u03b1 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7.<sup>50<\/sup> \u03a0\u03b1\u03c1\u03ac \u03c4\u03b1 \u03b8\u03b5\u03c4\u03b9\u03ba\u03ac \u03b1\u03c5\u03c4\u03ac \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1, \u03b7 \u03c0\u03b5\u03c0\u03c4\u03b9\u03b4\u03b9\u03ba\u03ae \u03c6\u03cd\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c5\u03c0\u03b1\u03c1\u03c7\u03cc\u03bd\u03c4\u03c9\u03bd GnRH \u03b1\u03bd\u03c4\u03b1\u03b3\u03c9\u03bd\u03b9\u03c3\u03c4\u03ce\u03bd \u03b5\u03c0\u03b9\u03b2\u03ac\u03bb\u03bb\u03b5\u03b9 \u03c4\u03b7 \u03c3\u03c5\u03c7\u03bd\u03ae \u03c0\u03b1\u03c1\u03b5\u03bd\u03c4\u03b5\u03c1\u03b9\u03ba\u03ae \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03ae \u03c4\u03bf\u03c5\u03c2, \u03b3\u03b5\u03b3\u03bf\u03bd\u03cc\u03c2 \u03c0\u03bf\u03c5 \u03c3\u03b5 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc \u03bc\u03b5 \u03c4\u03bf \u03c5\u03c8\u03b7\u03bb\u03cc \u03c4\u03bf\u03c5\u03c2 \u03ba\u03cc\u03c3\u03c4\u03bf\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03ba\u03b1\u03b8\u03b9\u03c3\u03c4\u03ac \u03bc\u03b7 \u03c0\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03c9\u03c2 \u03b1\u03bd\u03c4\u03b9\u03c3\u03c5\u03bb\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03ae \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf. \u0395\u03c0\u03af\u03c3\u03b7\u03c2, \u03c4\u03bf\u03bd\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03b1\u03bd\u03ac\u03b3\u03ba\u03b7 \u03c3\u03c5\u03b3\u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7\u03c2 \u03b1\u03bd\u03b4\u03c1\u03bf\u03b3\u03cc\u03bd\u03c9\u03bd \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03ce\u03c0\u03b9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03bd\u03b4\u03c1\u03bf\u03b3\u03bf\u03bd\u03bf\u03c0\u03b5\u03bd\u03af\u03b1\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af \u03b7 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03c9\u03bd \u03b3\u03bf\u03bd\u03b1\u03b4\u03bf\u03c4\u03c1\u03bf\u03c0\u03b9\u03bd\u03ce\u03bd. \u0397 \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 \u03bc\u03b7 \u03c0\u03b5\u03c0\u03c4\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03b1\u03bd\u03c4\u03b1\u03b3\u03c9\u03bd\u03b9\u03c3\u03c4\u03ce\u03bd \u03bc\u03b5 \u03b4\u03c5\u03bd\u03b1\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5 \u03c3\u03c4\u03cc\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7\u03c2,<sup>51<\/sup> \u03ba\u03b1\u03b8\u03ce\u03c2 \u03ba\u03b1\u03b9 \u03b5\u03bc\u03c6\u03c5\u03c4\u03b5\u03c5\u03bc\u03ac\u03c4\u03c9\u03bd \u03b2\u03c1\u03b1\u03b4\u03b5\u03af\u03b1\u03c2 \u03b1\u03c0\u03bf\u03b4\u03ad\u03c3\u03bc\u03b5\u03c5\u03c3\u03b7\u03c2 (\u03b9\u03c3\u03c4\u03c1\u03b5\u03bb\u03af\u03bd\u03b7) \u03af\u03c3\u03c9\u03c2 \u03b1\u03bd\u03b1\u03b8\u03b5\u03c1\u03bc\u03ac\u03bd\u03b5\u03b9 \u03c4\u03b7 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae \u03c4\u03c9\u03bd \u03bf\u03c5\u03c3\u03b9\u03ce\u03bd \u03b1\u03c5\u03c4\u03ce\u03bd \u03c3\u03c4\u03b7\u03bd \u03b1\u03bd\u03b4\u03c1\u03b9\u03ba\u03ae \u03b1\u03bd\u03c4\u03b9\u03c3\u03cd\u03bb\u03bb\u03b7\u03c8\u03b7.<sup>52<\/sup><\/p>\n<h5 style=\"text-align: justify;\">3.4. \u03a3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc\u03c2 \u03b1\u03bd\u03b4\u03c1\u03bf\u03b3\u03cc\u03bd\u03c9\u03bd &#8211; \u03c0\u03c1\u03bf\u03b3\u03b5\u03c3\u03c4\u03b1\u03b3\u03cc\u03bd\u03c9\u03bd<\/h5>\n<p style=\"text-align: justify;\">\u0397 \u03b1\u03bd\u03b1\u03c3\u03c4\u03b1\u03bb\u03c4\u03b9\u03ba\u03ae \u03b4\u03c1\u03ac\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c0\u03c1\u03bf\u03b3\u03b5\u03c3\u03c4\u03b1\u03b3\u03cc\u03bd\u03c9\u03bd \u03c3\u03c4\u03b7\u03bd \u03ad\u03ba\u03ba\u03c1\u03b9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b3\u03bf\u03bd\u03b1\u03b4\u03bf\u03c4\u03c1\u03bf\u03c0\u03b9\u03bd\u03ce\u03bd \u03c3\u03c4\u03bf \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03bf \u03c4\u03b7\u03c2 \u03c5\u03c0\u03cc\u03c6\u03c5\u03c3\u03b7\u03c2 \u03ad\u03c7\u03b5\u03b9 \u03bc\u03b5\u03bb\u03b5\u03c4\u03b7\u03b8\u03b5\u03af \u03b5\u03c0\u03af \u03bc\u03b5\u03b3\u03ac\u03bb\u03bf \u03b4\u03b9\u03ac\u03c3\u03c4\u03b7\u03bc\u03b1 \u03c3\u03c4\u03b9\u03c2 \u03b3\u03c5\u03bd\u03b1\u03af\u03ba\u03b5\u03c2, \u03b1\u03c6\u03bf\u03cd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03bf\u03cd\u03bd \u03b1\u03bd\u03b1\u03c0\u03cc\u03c3\u03c0\u03b1\u03c3\u03c4\u03bf \u03c3\u03c5\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03cc \u03c4\u03c9\u03bd \u03b3\u03c5\u03bd\u03b1\u03b9\u03ba\u03b5\u03af\u03c9\u03bd \u03b1\u03bd\u03c4\u03b9\u03c3\u03c5\u03bb\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03ce\u03bd. \u0391\u03bd\u03ac\u03bb\u03bf\u03b3\u03b7 \u03b4\u03c1\u03ac\u03c3\u03b7 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c4\u03b1 \u03c0\u03c1\u03bf\u03b3\u03b5\u03c3\u03c4\u03b1\u03b3\u03cc\u03bd\u03b1 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03bf\u03bd \u03ac\u03bd\u03b4\u03c1\u03b1, \u03b5\u03bd\u03ce \u03b5\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03b1\u03c3\u03ba\u03bf\u03cd\u03bd \u03ba\u03b1\u03b9 \u03ac\u03bc\u03b5\u03c3\u03b7 \u03b1\u03bd\u03b1\u03c3\u03c4\u03b1\u03bb\u03c4\u03b9\u03ba\u03ae \u03b4\u03c1\u03ac\u03c3\u03b7 \u03c3\u03c4\u03b7 \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7 \u03c3\u03c4\u03bf \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03bf \u03c4\u03bf\u03c5 \u03cc\u03c1\u03c7\u03b5\u03c9\u03c2. \u0395\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd, \u03b7 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03ad\u03bd\u03b7 \u03c7\u03c1\u03ae\u03c3\u03b7 \u03b1\u03bd\u03b4\u03c1\u03bf\u03b3\u03cc\u03bd\u03c9\u03bd \u03bc\u03b5 \u03c0\u03c1\u03bf\u03b3\u03b5\u03c3\u03c4\u03b1\u03b3\u03cc\u03bd\u03b1 \u03b5\u03c0\u03b9\u03c4\u03c1\u03ad\u03c0\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b5\u03c0\u03af\u03c4\u03b5\u03c5\u03be\u03b7 \u03c3\u03c5\u03b3\u03ba\u03c1\u03af\u03c3\u03b9\u03bc\u03c9\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03ac\u03c4\u03c9\u03bd \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03b9\u03c3\u03c4\u03b9\u03ba\u03ae \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03b1\u03bd\u03b4\u03c1\u03bf\u03b3\u03cc\u03bd\u03c9\u03bd \u03cc\u03c3\u03bf\u03bd \u03b1\u03c6\u03bf\u03c1\u03ac \u03c4\u03b7\u03bd \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03b7\u03c2 \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7\u03c2, \u03b5\u03c0\u03b9\u03c4\u03c1\u03ad\u03c0\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c9\u03c3\u03c4\u03cc\u03c3\u03bf \u03c4\u03b7 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b4\u03cc\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd \u03c7\u03bf\u03c1\u03b7\u03b3\u03bf\u03cd\u03bc\u03b5\u03bd\u03c9\u03bd \u03b1\u03bd\u03b4\u03c1\u03bf\u03b3\u03cc\u03bd\u03c9\u03bd. \u03a9\u03c2 \u03b5\u03ba \u03c4\u03bf\u03cd\u03c4\u03bf\u03c5 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b4\u03b9\u03b5\u03be\u03b1\u03c7\u03b8\u03b5\u03af \u03c0\u03bf\u03bb\u03c5\u03ac\u03c1\u03b9\u03b8\u03bc\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03bf\u03cd \u03b1\u03bd\u03b4\u03c1\u03bf\u03b3\u03cc\u03bd\u03c9\u03bd \u03bc\u03b5 \u03c0\u03c1\u03bf\u03b3\u03b5\u03c3\u03c4\u03b1\u03b3\u03cc\u03bd\u03b1, \u03b5\u03bd\u03ce \u03b7 \u03c0\u03c1\u03ce\u03c4\u03b7 \u03ba\u03b1\u03b9 \u03bc\u03bf\u03bd\u03b1\u03b4\u03b9\u03ba\u03ae \u03ad\u03c9\u03c2 \u03c4\u03ce\u03c1\u03b1 \u03c7\u03c1\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03bf\u03c4\u03bf\u03cd\u03bc\u03b5\u03bd\u03b7 \u03b1\u03c0\u03cc \u03c4\u03b7 \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03b2\u03b9\u03bf\u03bc\u03b7\u03c7\u03b1\u03bd\u03af\u03b1 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03b1\u03bd\u03b4\u03c1\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03c4\u03b9\u03c3\u03cd\u03bb\u03bb\u03b7\u03c8\u03b7\u03c2 \u03b2\u03b1\u03c3\u03af\u03c3\u03c4\u03b7\u03ba\u03b5 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03c3\u03b5 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc \u03c4\u03b5\u03c3\u03c4\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7\u03c2 \u03bc\u03b5 \u03c0\u03c1\u03bf\u03b3\u03b5\u03c3\u03c4\u03b1\u03b3\u03cc\u03bd\u03bf.<sup>7<\/sup><\/p>\n<hr style=\"width: 100%; border-width: 1px; border-style: solid; border-color: #CCCCCC; color: #ffffff;\" noshade=\"noshade\" width=\"100%\" \/>\n<p>\u03a3\u03cd\u03bd\u03bf\u03c8\u03b7 \u03c4\u03c9\u03bd \u03c5\u03c6\u03b9\u03c3\u03c4\u03ac\u03bc\u03b5\u03bd\u03c9\u03bd \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03c0\u03b5\u03b9\u03c1\u03b1\u03bc\u03b1\u03c4\u03b9\u03ba\u03ce\u03bd \u03bc\u03b5\u03b8\u03cc\u03b4\u03c9\u03bd \u03b1\u03bd\u03b4\u03c1\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03c4\u03b9\u03c3\u03cd\u03bb\u03bb\u03b7\u03c8\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03bd\u03c4\u03b9\u03c3\u03c5\u03bb\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03ac\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03b5\u03c6\u03cc\u03c3\u03bf\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1 (\u03b5\u03ba\u03c6\u03c1\u03b1\u03b6\u03cc\u03bc\u03b5\u03bd\u03b7 \u03c9\u03c2 \u03b4\u03b5\u03af\u03ba\u03c4\u03b7\u03c2 Pearl = \u03b1\u03bd\u03b5\u03c0\u03b9\u03b8\u03cd\u03bc\u03b7\u03c4\u03b5\u03c2 \u03b5\u03b3\u03ba\u03c5\u03bc\u03bf\u03c3\u03cd\u03bd\u03b5\u03c2 \u03b1\u03bd\u03ac 100 \u03ac\u03bd\u03b4\u03c1\u03b5\u03c2 \/ \u03ad\u03c4\u03b7 \u03ad\u03ba\u03b8\u03b5\u03c3\u03b7\u03c2.<\/p>\n<table style=\"width: 100%;\" border=\"0\" cellspacing=\"3\" cellpadding=\"3\" align=\"center\">\n<tbody>\n<tr style=\"background-color: #385a72;\">\n<td valign=\"top\" width=\"451\">\n<p align=\"center\"><strong><span style=\"color: #ffffff;\">\u03a5\u03c6\u03b9\u03c3\u03c4\u03ac\u03bc\u03b5\u03bd\u03b5\u03c2 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf\u03b9 \u03b1\u03bd\u03c4\u03b9\u03c3\u03cd\u03bb\u03bb\u03b7\u03c8\u03b7\u03c2<\/span><\/strong><\/p>\n<\/td>\n<td valign=\"top\" width=\"154\">\n<p align=\"center\"><strong><span style=\"color: #ffffff;\">Pearl Index (%)<\/span><\/strong><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td valign=\"top\" width=\"451\">\n<ul>\n<li>\u03a0\u03c1\u03bf\u03c6\u03c5\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ac<\/li>\n<li>\u0392\u03b1\u03b6\u03b5\u03ba\u03c4\u03bf\u03bc\u03ae<\/li>\n<\/ul>\n<\/td>\n<td valign=\"top\" width=\"154\">\n<p align=\"center\">15<\/p>\n<p align=\"center\">0.15<\/p>\n<\/td>\n<\/tr>\n<tr style=\"background-color: #385a72;\">\n<td valign=\"top\" width=\"451\">\n<p align=\"center\"><span style=\"color: #ffffff;\"><strong>\u039c\u03ad\u03b8\u03bf\u03b4\u03bf\u03b9 \u03b1\u03bd\u03c4\u03b9\u03c3\u03cd\u03bb\u03bb\u03b7\u03c8\u03b7\u03c2 \u03c5\u03c0\u03cc \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7<\/strong><\/span><\/p>\n<\/td>\n<td valign=\"top\" width=\"154\"><\/td>\n<\/tr>\n<tr>\n<td valign=\"top\" width=\"451\">\u039f\u03c1\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03b1\u03bd\u03c4\u03b9\u03c3\u03cd\u03bb\u03bb\u03b7\u03c8\u03b7<\/td>\n<td valign=\"top\" width=\"154\"><\/td>\n<\/tr>\n<tr>\n<td valign=\"top\" width=\"451\">\u039c\u03bf\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 \u03b1\u03bd\u03b4\u03c1\u03bf\u03b3\u03cc\u03bd\u03b1<\/p>\n<ul>\n<li>TE<\/li>\n<li>TU<\/li>\n<\/ul>\n<p>\u03a3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc\u03c2 \u03b1\u03bd\u03b4\u03c1\u03bf\u03b3\u03cc\u03bd\u03c9\u03bd \u03bc\u03b5:<\/p>\n<ul>\n<li>GnRH-\u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1<\/li>\n<li>\u03a0\u03c1\u03bf\u03b3\u03b5\u03c3\u03c4\u03b1\u03b3\u03cc\u03bd\u03b1 (DMPA + \u03b5\u03bc\u03c6\u03c5\u03c4\u03b5\u03cd\u03bc\u03b1\u03c4\u03b1 \u03a4)<\/li>\n<\/ul>\n<\/td>\n<td valign=\"top\" width=\"154\">\n<p align=\"center\">0.8-1.4<\/p>\n<p align=\"center\">0.18-0.6<\/p>\n<p align=\"center\">\u00a00<\/p>\n<\/td>\n<\/tr>\n<tr style=\"background-color: #385a72;\">\n<td style=\"text-align: center;\" colspan=\"2\" valign=\"top\" width=\"451\"><span style=\"color: #ffffff;\"><strong>\u039c\u03b7 \u03bf\u03c1\u03bc\u03bf\u03bd\u03b9\u03ba\u03ad\u03c2 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf\u03b9<\/strong><\/span><\/td>\n<\/tr>\n<tr>\n<td valign=\"top\" width=\"451\">\n<ol>\n<li>1.\u00a0\u00a0\u00a0\u00a0\u00a0 \u0391\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03b7\u03c2 \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7\u03c2<\/li>\n<\/ol>\n<p>\u2022 \u03a7\u03b7\u03bc\u03b9\u03ba\u03ad\u03c2 &#8211; \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03b5\u03c5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03b8\u03cc\u03b4\u03bf\u03c5\u03c2<\/p>\n<p>-\u0393\u03ba\u03bf\u03c3\u03c3\u03c5\u03c0\u03cc\u03bb\u03b7 &#8211; Adjudin &#8211; \u0399\u03bd\u03b4\u03b5\u03bd\u03bf\u03c0\u03c5\u03c1\u03b9\u03b4\u03af\u03bd\u03b5\u03c2<\/p>\n<p>-\u0391\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c1\u03b5\u03c4\u03b9\u03bd\u03bf\u03ca\u03ba\u03bf\u03cd \u03bf\u03be\u03ad\u03bf\u03c2 \u03c4\u03c9\u03bd \u03cc\u03c1\u03c7\u03b5\u03c9\u03bd<\/p>\n<p>\u2022 \u039c\u03b7\u03c7\u03b1\u03bd\u03b9\u03ba\u03ad\u03c2 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf\u03b9<\/p>\n<p>-\u03a3\u03c0\u03b1\u03c3\u03bf\u03c5\u03ac\u03c1 &#8211; \u03b5\u03be\u03c9\u03c4\u03b5\u03c1\u03b9\u03ba\u03ae \u03b8\u03ad\u03c1\u03bc\u03b1\u03bd\u03c3\u03b7 \u03c4\u03c9\u03bd \u03cc\u03c1\u03c7\u03b5\u03c9\u03bd<\/p>\n<p>-\u0397\u03c7\u03bf\u03b2\u03cc\u03bb\u03b7\u03c3\u03b7 \u03cc\u03c1\u03c7\u03b5\u03c9\u03bd<\/p>\n<ol>\n<li>2.\u00a0\u00a0\u00a0\u00a0\u00a0 \u0394\u03b9\u03b1\u03ba\u03bf\u03c0\u03ae \u03c4\u03b7\u03c2 \u03bc\u03b5\u03c4\u03b1\u03c6\u03bf\u03c1\u03ac\u03c2 \u03c4\u03bf\u03c5 \u03c3\u03c0\u03ad\u03c1\u03bc\u03b1\u03c4\u03bf\u03c2<\/li>\n<\/ol>\n<p>\u2022 \u03a6\u03b1\u03c1\u03bc\u03b1\u03ba\u03b5\u03c5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf\u03b9<\/p>\n<p>-\u0391\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03ac\u03bb\u03c6\u03b1-\u03b1\u03b4\u03c1\u03b5\u03bd\u03b5\u03c1\u03b3\u03b9\u03ba\u03ce\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03c9\u03bd<\/p>\n<p>-\u03a0\u03b5\u03c0\u03c4\u03b9\u03b4\u03b5\u03c1\u03b3\u03b9\u03ba\u03bf\u03af \u03b1\u03b3\u03c9\u03bd\u03b9\u03c3\u03c4\u03ad\u03c2<\/p>\n<p>\u2022 \u039c\u03b7\u03c7\u03b1\u03bd\u03b9\u03ba\u03ad\u03c2 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf\u03b9<\/p>\n<p>-RISUG<sup>a\u00a0\u00a0 <\/sup>&#8211; 1 \u03ba\u03cd\u03b7\u03c3\u03b7\/ 250 \u03ac\u03bd\u03b4\u03c1\u03b5\u03c2<sup><br \/>\n<\/sup><\/p>\n<p>-\u0395\u03bd\u03b4\u03bf\u03b1\u03c5\u03bb\u03b9\u03ba\u03ac \u03b2\u03cd\u03c3\u03bc\u03b1\u03c4\u03b1 &#8211; 0.21-0.65<\/p>\n<ol>\n<li>3.\u00a0\u00a0\u00a0\u00a0\u00a0 \u0391\u03b4\u03c1\u03b1\u03bd\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03b1\u03c0\u03bf\u03b8\u03b7\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03c9\u03bd \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b6\u03c9\u03b1\u03c1\u03af\u03c9\u03bd<\/li>\n<\/ol>\n<p>\u2022 \u0394\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ae \u03c4\u03b7\u03c2 \u03c3\u03cd\u03bd\u03b8\u03b5\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03c5\u03b3\u03c1\u03bf\u03cd \u03c4\u03b7\u03c2 \u03b5\u03c0\u03b9\u03b4\u03b9\u03b4\u03c5\u03bc\u03af\u03b4\u03b1\u03c2<\/p>\n<p>\u2022 \u0394\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ae \u03c4\u03bf\u03c5 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03c3\u03bc\u03bf\u03cd \u03c4\u03c9\u03bd \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b6\u03c9\u03b1\u03c1\u03af\u03c9\u03bd<\/p>\n<p>\u2022 \u0394\u03b9\u03ac\u03c1\u03c1\u03b7\u03be\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7\u03c2 \u03c3\u03c0\u03ad\u03c1\u03bc\u03b1\u03c4\u03bf\u03c2-\u03c9\u03b1\u03c1\u03af\u03bf\u03c5<\/p>\n<p>\u2022 \u0395\u03bd\u03b5\u03c1\u03b3\u03b7\u03c4\u03b9\u03ba\u03ae \u03b1\u03bd\u03bf\u03c3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03c3\u03c0\u03ad\u03c1\u03bc\u03b1\u03c4\u03bf\u03c2<\/td>\n<td style=\"width: 154px;\" valign=\"middle\">&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: center;\">\n<p style=\"text-align: center;\" align=\"center\">\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><sup>a <\/sup>Reversible Inhibition of Sperm Under Guidance<\/p>\n<hr style=\"width: 100%; border-width: 1px; border-style: solid; border-color: #CCCCCC; color: #ffffff;\" noshade=\"noshade\" width=\"100%\" \/>\n<p style=\"text-align: justify;\">\u03a4\u03b1 \u03c0\u03c1\u03bf\u03b3\u03b5\u03c3\u03c4\u03b1\u03b3\u03cc\u03bd\u03b1, \u03c0\u03bb\u03b7\u03bd \u03c4\u03b7\u03c2 \u03c0\u03c1\u03bf\u03b3\u03b5\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c5\u03bd\u03b8\u03b5\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c0\u03c1\u03bf\u03ad\u03bb\u03b5\u03c5\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b1\u03be\u03b9\u03bd\u03bf\u03bc\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b1 19-\u03bd\u03bf\u03c1\u03c3\u03c4\u03b5\u03c1\u03bf\u03b5\u03b9\u03b4\u03ae, \u03c4\u03b1 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c0\u03c1\u03bf\u03ad\u03c1\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03c4\u03b5\u03c3\u03c4\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03b1 21-\u03c0\u03c1\u03bf\u03b3\u03b5\u03c3\u03c4\u03b9\u03bd\u03bf\u03b5\u03b9\u03b4\u03ae \u03ae \u03c0\u03c1\u03b5\u03b3\u03bd\u03ac\u03bd\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03b2\u03b1\u03c3\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03c0\u03c1\u03bf\u03b3\u03b5\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7. \u0397 \u03c0\u03c1\u03ce\u03c4\u03b7 \u03b3\u03b5\u03bd\u03b9\u03ac 19-\u03bd\u03bf\u03c1\u03c3\u03c4\u03b5\u03c1\u03bf\u03b5\u03b9\u03b4\u03ce\u03bd \u03bf\u03bd\u03bf\u03bc\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b5\u03c3\u03c4\u03c1\u03ac\u03bd\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03b2\u03b1\u03c3\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03bd\u03bf\u03c1\u03b5\u03b8\u03b9\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7, \u03b5\u03bd\u03ce \u03b7 \u03b4\u03b5\u03cd\u03c4\u03b5\u03c1\u03b7 \u03b3\u03b5\u03bd\u03b9\u03ac (\u03b3\u03bf\u03bd\u03ac\u03bd\u03b5\u03c2) \u03c0\u03c1\u03bf\u03ad\u03c1\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7 \u03bb\u03b5\u03b2\u03bf\u03bd\u03bf\u03c1\u03b3\u03b5\u03c3\u03c4\u03c1\u03ad\u03bb\u03b7 (\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 1).<\/p>\n<hr style=\"width: 100%; border-width: 1px; border-style: solid; border-color: #CCCCCC; color: #ffffff;\" noshade=\"noshade\" width=\"100%\" \/>\n<p style=\"text-align: justify;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-100572\" alt=\"9.11img1\" src=\"https:\/\/e-endocrinology.gr\/wp-content\/uploads\/2015\/09\/9.11img1.jpg\" width=\"562\" height=\"278\" srcset=\"https:\/\/e-endocrinology.gr\/wp-content\/uploads\/2015\/09\/9.11img1.jpg 562w, https:\/\/e-endocrinology.gr\/wp-content\/uploads\/2015\/09\/9.11img1-300x148.jpg 300w\" sizes=\"(max-width: 562px) 100vw, 562px\" \/><\/p>\n<p><b>\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 1<\/b>. \u03a4\u03b1\u03be\u03b9\u03bd\u03cc\u03bc\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c3\u03c5\u03bd\u03b8\u03b5\u03c4\u03b9\u03ba\u03ce\u03bd \u03c0\u03c1\u03bf\u03b3\u03b5\u03c3\u03c4\u03b1\u03b3\u03cc\u03bd\u03c9\u03bd.<\/p>\n<hr style=\"width: 100%; border-width: 1px; border-style: solid; border-color: #CCCCCC; color: #ffffff;\" noshade=\"noshade\" width=\"100%\" \/>\n<h6>\u00a03.4.1. \u039d\u03bf\u03c1\u03b5\u03b8\u03b9\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7<\/h6>\n<p style=\"text-align: justify;\">\u0397 \u03bd\u03bf\u03c1\u03b5\u03b8\u03b9\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b1\u03c1\u03ac\u03b3\u03c9\u03b3\u03bf \u03c4\u03b7\u03c2 \u03c4\u03b5\u03c3\u03c4\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7\u03c2 \u03bc\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae \u03b1\u03bd\u03b4\u03c1\u03bf\u03b3\u03cc\u03bd\u03bf \u03b4\u03c1\u03ac\u03c3\u03b7 (~10% \u03c4\u03b7\u03c2 \u03c4\u03b5\u03c3\u03c4\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7\u03c2), \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c3\u03c4\u03b7\u03bd \u03b5\u03bd\u03b1\u03bd\u03b8\u03b9\u03ba\u03ae \u03bc\u03bf\u03c1\u03c6\u03ae (\u039d\u0395\u03a4E) \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c7\u03bf\u03c1\u03b7\u03b3\u03b7\u03b8\u03b5\u03af \u03c9\u03c2 \u03bc\u03b1\u03ba\u03c1\u03ac\u03c2 \u03b4\u03c1\u03ac\u03c3\u03b5\u03c9\u03c2 \u03b5\u03bd\u03ad\u03c3\u03b9\u03bc\u03bf \u03c3\u03ba\u03b5\u03cd\u03b1\u03c3\u03bc\u03b1, \u03b5\u03bd\u03ce \u03bc\u03b5 \u03c4\u03b7 \u03bc\u03bf\u03c1\u03c6\u03ae \u03c4\u03b7\u03c2 \u03bf\u03be\u03b9\u03ba\u03ae\u03c2 \u03bd\u03bf\u03c1\u03b5\u03b8\u03b9\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7\u03c2 (\u039d\u0395\u03a4\u0391) \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03c6\u03b9\u03ba\u03c4\u03ae \u03b7 \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5 \u03c3\u03c4\u03cc\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7. \u03a3\u03b5 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03b1\u03bd\u03b4\u03c1\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03c4\u03b9\u03c3\u03cd\u03bb\u03bb\u03b7\u03c8\u03b7\u03c2, \u039d\u0395\u03a4\u0395 \u03c3\u03c5\u03b3\u03c7\u03bf\u03c1\u03b7\u03b3\u03bf\u03cd\u03bc\u03b5\u03bd\u03b7 \u03bc\u03b5 TU \u03b1\u03bd\u03ac \u03b4\u03b9\u03b1\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03b1 6-8 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03c9\u03bd \u03b5\u03c0\u03b9\u03c4\u03c5\u03b3\u03c7\u03ac\u03bd\u03b5\u03b9 \u03c5\u03c8\u03b7\u03bb\u03ac \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03ac \u03b1\u03b6\u03c9\u03bf\u03c3\u03c0\u03b5\u03c1\u03bc\u03af\u03b1\u03c2 \u03c0\u03bf\u03c5 \u03b1\u03b3\u03b3\u03af\u03b6\u03bf\u03c5\u03bd \u03c4\u03bf 90%.<sup>33, 53<\/sup> \u039f \u03bf\u03c1\u03b3\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1 \u03c3\u03c4\u03b7\u03bd \u03b1\u03bd\u03c4\u03b9\u03c3\u03cd\u03bb\u03bb\u03b7\u03c8\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 (Contraception\u00a0Research and Development \u2013 CONRAD) \u03c3\u03b5 \u03c3\u03c5\u03bd\u03b5\u03c1\u03b3\u03b1\u03c3\u03af\u03b1 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03a0\u039f\u03a5 \u03c7\u03c1\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03cc\u03c4\u03b7\u03c3\u03b5 \u03bc\u03b9\u03b1 \u03c0\u03bf\u03bb\u03c5\u03ba\u03b5\u03bd\u03c4\u03c1\u03b9\u03ba\u03ae \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c6\u03ac\u03c3\u03b7\u03c2 \u0399\u0399 \u03c3\u03c5\u03b3\u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7\u03c2 200 mg NETE \u03bc\u03b5 1000 mg TU \u03b1\u03bd\u03ac 8 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03b5\u03c0\u03af 48 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2, \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03b1\u03c1\u03c7\u03b9\u03ba\u03ac \u03c0\u03b5\u03c1\u03b9\u03b5\u03bb\u03ac\u03bc\u03b2\u03b1\u03bd\u03b5, 321 \u03b6\u03b5\u03c5\u03b3\u03ac\u03c1\u03b9\u03b1. \u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03b4\u03b9\u03b1\u03ba\u03cc\u03c0\u03b7\u03ba\u03b5 \u03c0\u03c1\u03cc\u03c9\u03c1\u03b1 \u03bb\u03cc\u03b3\u03c9 \u03c4\u03b7\u03c2 \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7\u03c2 \u03c3\u03bf\u03b2\u03b1\u03c1\u03ce\u03bd \u03b1\u03bd\u03b5\u03c0\u03b9\u03b8\u03cd\u03bc\u03b7\u03c4\u03c9\u03bd \u03b5\u03bd\u03b5\u03c1\u03b3\u03b5\u03b9\u03ce\u03bd \u03ba\u03b1\u03b9 \u03b7 \u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c0\u03c1\u03bf\u03c3\u03c9\u03c1\u03b9\u03bd\u03ce\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03ac\u03c4\u03c9\u03bd \u03b4\u03b5\u03bd \u03ad\u03c7\u03b5\u03b9 \u03b4\u03b7\u03bc\u03bf\u03c3\u03b9\u03b5\u03c5\u03b8\u03b5\u03af \u03b1\u03ba\u03cc\u03bc\u03b7 (<a href=\"http:\/\/conrad.org\/contraception-trials.html\" target=\"_blank\">http:\/\/conrad.org\/contraception-trials.html<\/a>).<\/p>\n<h6 style=\"text-align: justify;\">3.4.2. \u039b\u03b5\u03b2\u03bf\u03bd\u03bf\u03c1\u03b3\u03b5\u03c3\u03c4\u03c1\u03ad\u03bb\u03b7 \u2013 \u03b4\u03b5\u03c3\u03bf\u03b3\u03b5\u03c3\u03c4\u03c1\u03ad\u03bb\u03b7 \u2013 \u03b5\u03c4\u03bf\u03bd\u03bf\u03b3\u03b5\u03c3\u03c4\u03c1\u03ad\u03bb\u03b7<\/h6>\n<p style=\"text-align: justify;\">\u0397 \u03bb\u03b5\u03b2\u03bf\u03bd\u03bf\u03c1\u03b3\u03b5\u03c3\u03c4\u03c1\u03ad\u03bb\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b1\u03c1\u03ac\u03b3\u03c9\u03b3\u03bf \u03c4\u03b7\u03c2 \u03bd\u03bf\u03c1\u03b5\u03b8\u03b9\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7\u03c2, \u03c4\u03bf \u03bf\u03c0\u03bf\u03af\u03bf \u03b4\u03cd\u03bd\u03b1\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03c7\u03bf\u03c1\u03b7\u03b3\u03b7\u03b8\u03b5\u03af \u03ba\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5 \u03c3\u03c4\u03cc\u03bc\u03b1\u03c4\u03bf\u03c2. \u03a3\u03b5 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03ad\u03c7\u03b5\u03b9 \u03c7\u03bf\u03c1\u03b7\u03b3\u03b7\u03b8\u03b5\u03af \u03c3\u03b5 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc \u03bc\u03b5 \u03a4\u0395 \u03ba\u03b1\u03b9 \u03a4U \u03b5\u03bd\u03b9\u03c3\u03c7\u03cd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03b5\u03bb\u03b1\u03c6\u03c1\u03ce\u03c2 \u03c4\u03b7\u03bd \u03b1\u03bd\u03c4\u03b9\u03c3\u03c5\u03bb\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03ae \u03c4\u03bf\u03c5\u03c2 \u03b4\u03c1\u03ac\u03c3\u03b7, \u03b5\u03bd\u03ce \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b7 \u03bc\u03bf\u03c1\u03c6\u03ae \u03b5\u03bc\u03c6\u03c5\u03c4\u03b5\u03c5\u03bc\u03ac\u03c4\u03c9\u03bd \u03bc\u03b1\u03ba\u03c1\u03ac\u03c2 \u03b4\u03c1\u03ac\u03c3\u03b7\u03c2 \u03c3\u03b5 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc \u03bc\u03b5 \u03a4U 1000 mg \u03ba\u03ac\u03b8\u03b5 8 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03c3\u03b5 \u03ba\u03b9\u03bd\u03ad\u03b6\u03bf\u03c5\u03c2 \u03ac\u03bd\u03b4\u03c1\u03b5\u03c2, \u03bf\u03b4\u03ae\u03b3\u03b7\u03c3\u03b5 \u03c3\u03b5 \u03b1\u03b6\u03c9\u03bf\u03c3\u03c0\u03b5\u03c1\u03bc\u03af\u03b1 \u03c3\u03b5 \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc 90%.<sup>54<\/sup><\/p>\n<p style=\"text-align: justify;\">\u0397 \u03b4\u03b5\u03c3\u03bf\u03b3\u03b5\u03c3\u03c4\u03c1\u03ad\u03bb\u03b7 (DSG) \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b1\u03c1\u03ac\u03b3\u03c9\u03b3\u03bf \u03c4\u03b7\u03c2 \u03bb\u03b5\u03b2\u03bf\u03bd\u03bf\u03c1\u03b3\u03b5\u03c3\u03c4\u03c1\u03ad\u03bb\u03b7\u03c2, \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c7\u03bf\u03c1\u03b7\u03b3\u03bf\u03cd\u03bc\u03b5\u03bd\u03b7 \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5 \u03c3\u03c4\u03cc\u03bc\u03b1\u03c4\u03bf\u03c2 \u03bc\u03b5\u03c4\u03b1\u03c4\u03c1\u03ad\u03c0\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf\u03bd \u03b5\u03bd\u03b5\u03c1\u03b3\u03cc \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03af\u03c4\u03b7 \u03c4\u03b7\u03c2: \u03c4\u03b7\u03bd \u03b5\u03c4\u03bf\u03bd\u03bf\u03b3\u03b5\u03c3\u03c4\u03c1\u03ad\u03bb\u03b7 (ENG). H DSG \u03ad\u03c7\u03b5\u03b9 \u03b4\u03bf\u03ba\u03b9\u03bc\u03b1\u03c3\u03c4\u03b5\u03af \u03c9\u03c2 \u03b1\u03bd\u03b4\u03c1\u03b9\u03ba\u03cc \u03b1\u03bd\u03c4\u03b9\u03c3\u03c5\u03bb\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03cc \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5 \u03c3\u03c4\u03cc\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c3\u03b5 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc \u03b5\u03af\u03c4\u03b5 \u03bc\u03b5 \u03b5\u03bd\u03ad\u03c3\u03b9\u03bc\u03b7 \u03a4\u0395 \u03ae \u03bc\u03b5 \u03b5\u03bc\u03c6\u03c5\u03c4\u03b5\u03cd\u03c3\u03b9\u03bc\u03b1 \u03c3\u03c6\u03b1\u03b9\u03c1\u03af\u03b4\u03b9\u03b1 \u03c4\u03b5\u03c3\u03c4\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7\u03c2, \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03ce\u03bd\u03c4\u03b1\u03c2 \u03b1\u03b6\u03c9\u03bf\u03c3\u03c0\u03b5\u03c1\u03bc\u03af\u03b1 \u03c3\u03b5 80-90% \u03c4\u03c9\u03bd \u03b1\u03bd\u03b4\u03c1\u03ce\u03bd \u03c0\u03bf\u03c5 \u03c7\u03bf\u03c1\u03b7\u03b3\u03ae\u03b8\u03b7\u03ba\u03b5.<sup>55<\/sup> \u039f \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc\u03c2 \u0395NG \u03bc\u03b5 \u03c4\u03b7 \u03bc\u03bf\u03c1\u03c6\u03ae \u03b5\u03bc\u03c6\u03c5\u03c4\u03b5\u03c5\u03bc\u03ac\u03c4\u03c9\u03bd \u03c3\u03b5 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc \u03bc\u03b5 TU \u03b5\u03bd\u03b4\u03bf\u03bc\u03c5\u03ca\u03ba\u03ac \u03b1\u03bd\u03ac 10-12 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03b5 \u03c4\u03bf \u03b1\u03bd\u03c4\u03b9\u03ba\u03b5\u03af\u03bc\u03b5\u03bd\u03bf \u03c0\u03bf\u03bb\u03c5\u03ba\u03b5\u03bd\u03c4\u03c1\u03b9\u03ba\u03ae\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7\u03c2 \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03b5\u03b9\u03ba\u03bf\u03bd\u03b9\u03ba\u03bf\u03cd \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5, \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c7\u03c1\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03bf\u03c4\u03ae\u03b8\u03b7\u03ba\u03b5 \u03b1\u03c0\u03cc \u03c4\u03b7 \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03b2\u03b9\u03bf\u03bc\u03b7\u03c7\u03b1\u03bd\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c0\u03b5\u03c1\u03b9\u03b5\u03bb\u03ac\u03bc\u03b2\u03b1\u03bd\u03b5 354 \u03b5\u03b8\u03b5\u03bb\u03bf\u03bd\u03c4\u03ad\u03c2. \u03a3\u03c4\u03bf 90 % \u03c4\u03c9\u03bd \u03b1\u03bd\u03b4\u03c1\u03ce\u03bd \u03b5\u03c0\u03b9\u03c4\u03b5\u03cd\u03c7\u03b8\u03b7\u03ba\u03b1\u03bd \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03bf\u03bb\u03b9\u03b3\u03bf\u03b6\u03c9\u03bf\u03c3\u03c0\u03b5\u03c1\u03bc\u03af\u03b1\u03c2 \u2264 1 \u03b5\u03ba\u03b1\u03c4\u03bf\u03bc\u03bc\u03cd\u03c1\u03b9\u03bf\/ml, \u03c9\u03c3\u03c4\u03cc\u03c3\u03bf \u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03b4\u03b5\u03bd \u03c0\u03c1\u03bf\u03c7\u03ce\u03c1\u03b7\u03c3\u03b5 \u03c3\u03c4\u03b7 \u03c6\u03ac\u03c3\u03b7 \u03b1\u03bd\u03c4\u03b9\u03c3\u03c5\u03bb\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03bb\u03cc\u03b3\u03c9 \u03b1\u03c0\u03cc\u03c3\u03c5\u03c1\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03b5\u03bd\u03b4\u03b9\u03b1\u03c6\u03ad\u03c1\u03bf\u03bd\u03c4\u03bf\u03c2 \u03c4\u03c9\u03bd \u03c7\u03bf\u03c1\u03b7\u03b3\u03ce\u03bd.<sup>7<\/sup><\/p>\n<h6 style=\"text-align: justify;\">3.4.3. \u039f\u03be\u03b9\u03ba\u03ae \u03bc\u03b5\u03b4\u03c1\u03bf\u03be\u03c5\u03c0\u03c1\u03bf\u03b3\u03b5\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7 &#8211; \u03bf\u03be\u03b9\u03ba\u03ae \u03ba\u03c5\u03c0\u03c1\u03bf\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7 &#8211; \u03bd\u03b5\u03c3\u03c4\u03bf\u03c1\u03cc\u03bd\u03b7<\/h6>\n<p style=\"text-align: justify;\">\u0397 \u03bf\u03be\u03b9\u03ba\u03ae \u03bc\u03b5\u03b4\u03c1\u03bf\u03be\u03c5\u03c0\u03c1\u03bf\u03b3\u03b5\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7, \u03c0\u03b1\u03c1\u03ac\u03b3\u03c9\u03b3\u03bf \u03c4\u03b7\u03c2 \u03c0\u03c1\u03bf\u03b3\u03b5\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7\u03c2, \u03ad\u03c7\u03b5\u03b9 \u03b4\u03bf\u03ba\u03b9\u03bc\u03b1\u03c3\u03c4\u03b5\u03af \u03c3\u03c4\u03b7\u03bd \u03b1\u03bd\u03b4\u03c1\u03b9\u03ba\u03ae \u03b1\u03bd\u03c4\u03b9\u03c3\u03cd\u03bb\u03bb\u03b7\u03c8\u03b7 \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03c0\u03c1\u03ce\u03c4\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03bf\u03cd \u03c3\u03c4\u03b7 \u03b4\u03b5\u03ba\u03b1\u03b5\u03c4\u03af\u03b1 \u03c4\u03bf\u03c5 1970.<sup>56<\/sup> \u0397 \u03b4\u03b9\u03ac\u03b8\u03b5\u03c3\u03ae \u03c4\u03b7\u03c2 \u03c3\u03b5 \u03b5\u03bd\u03ad\u03c3\u03b9\u03bc\u03b7 depot \u03bc\u03bf\u03c1\u03c6\u03ae (DMPA) \u03c4\u03b7\u03bd \u03ba\u03b1\u03b8\u03b9\u03c3\u03c4\u03ac \u03b5\u03cd\u03c7\u03c1\u03b7\u03c3\u03c4\u03b7 \u03ba\u03b1\u03b9 \u03ad\u03c7\u03b5\u03b9 \u03b4\u03bf\u03ba\u03b9\u03bc\u03b1\u03c3\u03c4\u03b5\u03af \u03c3\u03b5 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc \u03bc\u03b5 \u03b5\u03bc\u03c6\u03c5\u03c4\u03b5\u03cd\u03bc\u03b1\u03c4\u03b1 \u03c4\u03b5\u03c3\u03c4\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7\u03c2 \u03bc\u03b5 \u03b5\u03c0\u03af\u03c4\u03b5\u03c5\u03be\u03b7 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae\u03c2 \u03bf\u03bb\u03b9\u03b3\u03bf\u03b6\u03c9\u03bf\u03c3\u03c0\u03b5\u03c1\u03bc\u03af\u03b1\u03c2 (&lt;1 \u03b5\u03ba\u03b1\u03c4\u03bf\u03bc\u03bc\u03cd\u03c1\u03b9\u03bf \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b6\u03c9\u03ac\u03c1\u03b9\u03b1 \/ ml) \u03c3\u03b5 \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc 96%.<sup>57<\/sup> \u03a3\u03b5 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc \u03bc\u03b5 TU \u03c3\u03b5 \u03b4\u03cc\u03c3\u03b7 1000 mg \u03ba\u03ac\u03b8\u03b5 8 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03c4\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03ae\u03c4\u03b1\u03bd \u03b1\u03ba\u03cc\u03bc\u03b7 \u03c0\u03b9\u03bf \u03b5\u03bd\u03b8\u03b1\u03c1\u03c1\u03c5\u03bd\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5 \u03b5\u03c0\u03af\u03c4\u03b5\u03c5\u03be\u03b7 \u03b1\u03b6\u03c9\u03bf\u03c3\u03c0\u03b5\u03c1\u03bc\u03af\u03b1\u03c2 \u03c3\u03c4\u03bf \u03c3\u03cd\u03bd\u03bf\u03bb\u03bf \u03c4\u03c9\u03bd 30 \u03b5\u03b8\u03b5\u03bb\u03bf\u03bd\u03c4\u03ce\u03bd \u03ba\u03b9\u03bd\u03b5\u03b6\u03b9\u03ba\u03ae\u03c2 \u03b5\u03b8\u03bd\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2. \u039c\u03b5\u03b9\u03bf\u03bd\u03ad\u03ba\u03c4\u03b7\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b9\u03c2 \u03b4\u03cd\u03bf \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03ae\u03c4\u03b1\u03bd \u03b7 \u03b2\u03c1\u03b1\u03b4\u03b5\u03af\u03b1 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03b7\u03c2 \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7\u03c2.<sup>58<\/sup><\/p>\n<p style=\"text-align: justify;\">\u0397 \u03bf\u03be\u03b9\u03ba\u03ae \u03ba\u03c5\u03c0\u03c1\u03bf\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7 (CPA) \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03c0\u03b1\u03c1\u03ac\u03b3\u03c9\u03b3\u03bf \u03c4\u03b7\u03c2 \u03c0\u03c1\u03bf\u03b3\u03b5\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7\u03c2 \u03bc\u03b5 \u03b9\u03c3\u03c7\u03c5\u03c1\u03ae \u03b1\u03bd\u03c4\u03b9-\u03b1\u03bd\u03b4\u03c1\u03bf\u03b3\u03bf\u03bd\u03b9\u03ba\u03ae \u03b4\u03c1\u03ac\u03c3\u03b7, \u03b3\u03b5\u03b3\u03bf\u03bd\u03cc\u03c2 \u03c0\u03bf\u03c5 \u03b5\u03c0\u03b9\u03b2\u03ac\u03bb\u03bb\u03b5\u03b9 \u03c4\u03b7 \u03c3\u03c5\u03b3\u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03b1\u03bd\u03b4\u03c1\u03bf\u03b3\u03cc\u03bd\u03c9\u03bd \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03c0\u03bf\u03c6\u03c5\u03b3\u03ae \u03c3\u03c5\u03bc\u03c0\u03c4\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03b1\u03bd\u03b4\u03c1\u03bf\u03b3\u03bf\u03bd\u03bf\u03c0\u03b5\u03bd\u03af\u03b1\u03c2. \u03a3\u03b5 \u03bc\u03af\u03b1 \u03bc\u03b9\u03ba\u03c1\u03ae \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7, \u03b7 \u03c3\u03c5\u03b3\u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 100mg CPA \u03bc\u03b1\u03b6\u03af \u03bc\u03b5 TE 100mg \u03b1\u03bd\u03ac \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b1 \u03b5\u03af\u03c7\u03b5 \u03c9\u03c2 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03b7\u03bd \u03c0\u03c1\u03cc\u03ba\u03bb\u03b7\u03c3\u03b7 \u03b1\u03b6\u03c9\u03bf\u03c3\u03c0\u03b5\u03c1\u03bc\u03af\u03b1\u03c2 \u03c3\u03c4\u03bf \u03c3\u03cd\u03bd\u03bf\u03bb\u03bf \u03c4\u03c9\u03bd 15 \u03b5\u03b8\u03b5\u03bb\u03bf\u03bd\u03c4\u03ce\u03bd.<sup>59<\/sup> \u03a3\u03c4\u03b7 \u03c3\u03c5\u03bd\u03ad\u03c7\u03b5\u03b9\u03b1, \u03c6\u03ac\u03bd\u03b7\u03ba\u03b5 \u03cc\u03c4\u03b9 \u03b7 CPA \u03c3\u03b5 \u03bc\u03b9\u03ba\u03c1\u03ad\u03c2 \u03b4\u03cc\u03c3\u03b5\u03b9\u03c2 2 mg \/ \u03b7\u03bc\u03ad\u03c1\u03b1 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03c3\u03b5 \u03bd\u03b1 \u03c3\u03c5\u03bd\u03c4\u03b7\u03c1\u03ae\u03c3\u03b5\u03b9 \u03c4\u03b7 \u03c3\u03bf\u03b2\u03b1\u03c1\u03ae \u03bf\u03bb\u03b9\u03b3\u03bf\u03b6\u03c9\u03bf\u03c3\u03c0\u03b5\u03c1\u03bc\u03af\u03b1 \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ba\u03bb\u03ae\u03b8\u03b7\u03ba\u03b5 \u03b1\u03c0\u03cc \u03b4\u03cc\u03c3\u03b7 \u03b5\u03c6\u03cc\u03b4\u03bf\u03c5 20 mg \u03b7\u03bc\u03b5\u03c1\u03b7\u03c3\u03af\u03c9\u03c2 \u03bc\u03b1\u03b6\u03af \u03bc\u03b5 TU 1.000mg \u03ba\u03ac\u03b8\u03b5 6 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2.<sup>60<\/sup> \u03a0\u03b9\u03b8\u03b1\u03bd\u03ce\u03c2 \u03bb\u03cc\u03b3\u03c9 \u03c4\u03b7\u03c2 \u03b1\u03bd\u03c4\u03b9-\u03b1\u03bd\u03b4\u03c1\u03bf\u03b3\u03cc\u03bd\u03bf\u03c5 \u03b4\u03c1\u03ac\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 CPA \u03c3\u03c4\u03bf \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03bf \u03c4\u03bf\u03c5 \u03cc\u03c1\u03c7\u03b5\u03c9\u03c2, \u03bf \u03c7\u03c1\u03cc\u03bd\u03bf\u03c2 \u03c0\u03bf\u03c5 \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03b7\u03c2 \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03bc\u03b9\u03ba\u03c1\u03cc\u03c4\u03b5\u03c1\u03bf\u03c2 \u03b1\u03c0\u03cc \u03b1\u03c5\u03c4\u03cc\u03bd \u03c0\u03bf\u03c5 \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03b9\u03c3\u03c4\u03b9\u03ba\u03ae \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 TU.<sup>59<\/sup><\/p>\n<p style=\"text-align: justify;\">\u03a0\u03c1\u03cc\u03c3\u03c6\u03b1\u03c4\u03b1, \u03b5\u03bb\u03ad\u03b3\u03c7\u03b8\u03b7\u03ba\u03b5 \u03c3\u03b5 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03ad\u03bd\u03b1 \u03c3\u03c7\u03ae\u03bc\u03b1 \u03b4\u03b9\u03b1\u03b4\u03b5\u03c1\u03bc\u03b9\u03ba\u03ae\u03c2 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7\u03c2, \u03c0\u03bf\u03c5 \u03b2\u03b1\u03c3\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b3\u03ad\u03bb\u03b7 \u03c4\u03b5\u03c3\u03c4\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03bd\u03b5\u03c3\u03c4\u03bf\u03c1\u03cc\u03bd\u03b7\u03c2, \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03b7\u03bd \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03b7\u03c2 \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7\u03c2 \u03c3\u03b5 &lt;1 \u03b5\u03ba\u03b1\u03c4\u03bf\u03bc\u03bc\u03cd\u03c1\u03b9\u03bf \/ ml \u03c3\u03b5 88,5% \u03c4\u03c9\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd, \u03c7\u03c9\u03c1\u03af\u03c2 \u03c3\u03bf\u03b2\u03b1\u03c1\u03ad\u03c2 \u03b1\u03bd\u03b5\u03c0\u03b9\u03b8\u03cd\u03bc\u03b7\u03c4\u03b5\u03c2 \u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2.<sup>61<\/sup> \u0395\u03af\u03bd\u03b1\u03b9 \u03b5\u03bd\u03b4\u03b9\u03b1\u03c6\u03ad\u03c1\u03bf\u03bd \u03cc\u03c4\u03b9, \u03c0\u03ac\u03bd\u03c9 \u03b1\u03c0\u03cc \u03c4\u03bf 50% \u03c4\u03c9\u03bd \u03b1\u03bd\u03b4\u03c1\u03ce\u03bd \u03c0\u03bf\u03c5 \u03ad\u03bb\u03b1\u03b2\u03b1\u03bd \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03ae\u03c4\u03b1\u03bd \u03b9\u03ba\u03b1\u03bd\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03bf\u03b9 \u03ae \u03c0\u03bf\u03bb\u03cd \u03b9\u03ba\u03b1\u03bd\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03bf\u03b9 \u03ba\u03b1\u03b9 \u03b4\u03ae\u03bb\u03c9\u03c3\u03b1\u03bd \u03cc\u03c4\u03b9 \u03b8\u03b1 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03c3\u03b1\u03bd \u03b1\u03c5\u03c4\u03cc \u03c4\u03bf \u03c3\u03c7\u03ae\u03bc\u03b1, \u03b1\u03bd \u03b4\u03b9\u03b1\u03c4\u03af\u03b8\u03b5\u03c4\u03bf \u03c3\u03c4\u03bf \u03b5\u03bc\u03c0\u03cc\u03c1\u03b9\u03bf.<sup>62<\/sup><\/p>\n<p style=\"text-align: justify;\">\u03a3\u03b5 \u03bc\u03af\u03b1 \u03c0\u03c1\u03bf\u03c3\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1 \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c4\u03c9\u03bd \u03b4\u03b9\u03b1\u03c6\u03cc\u03c1\u03c9\u03bd \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03ce\u03bd \u03bf\u03c1\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03b4\u03c1\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03c4\u03b9\u03c3\u03cd\u03bb\u03bb\u03b7\u03c8\u03b7\u03c2, \u03b4\u03b7\u03bc\u03bf\u03c3\u03b9\u03b5\u03cd\u03b8\u03b7\u03ba\u03b5 \u03c4\u03bf 2012 \u03bc\u03b9\u03b1 \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b1\u03bd\u03b1\u03c3\u03ba\u03cc\u03c0\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b2\u03ac\u03c3\u03b7\u03c2 \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03c9\u03bd Cochrane, \u03c3\u03c4\u03b7\u03bd \u03bf\u03c0\u03bf\u03af\u03b1 \u03b1\u03be\u03b9\u03bf\u03bb\u03bf\u03b3\u03ae\u03b8\u03b7\u03ba\u03b1\u03bd 33 \u03c4\u03c5\u03c7\u03b1\u03b9\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b5\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03bc\u03b5 \u03ba\u03b1\u03c4\u03b1\u03bb\u03b7\u03ba\u03c4\u03b9\u03ba\u03cc \u03c3\u03b7\u03bc\u03b5\u03af\u03bf \u03c4\u03b7\u03bd \u03b5\u03c0\u03af\u03c4\u03b5\u03c5\u03be\u03b7 \u03b1\u03b6\u03c9\u03bf\u03c3\u03c0\u03b5\u03c1\u03bc\u03af\u03b1\u03c2. \u03a4\u03bf \u03c3\u03c5\u03bc\u03c0\u03ad\u03c1\u03b1\u03c3\u03bc\u03b1 \u03b1\u03c5\u03c4\u03ae\u03c2 \u03c4\u03b7\u03c2 \u03b1\u03bd\u03b1\u03c3\u03ba\u03cc\u03c0\u03b7\u03c3\u03b7\u03c2 \u03ae\u03c4\u03b1\u03bd \u03cc\u03c4\u03b9 \u03b1\u03bd \u03ba\u03b1\u03b9 \u03b7 \u03c0\u03c1\u03bf\u03c3\u03b8\u03ae\u03ba\u03b7 \u03c0\u03c1\u03bf\u03b3\u03b5\u03c3\u03c4\u03b1\u03b3\u03cc\u03bd\u03bf\u03c5 \u03b2\u03b5\u03bb\u03c4\u03af\u03c9\u03bd\u03b5 \u03b3\u03b5\u03bd\u03b9\u03ba\u03ac \u03c4\u03b7\u03bd \u03b1\u03bd\u03c4\u03b9\u03c3\u03c5\u03bb\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c4\u03b7\u03c2 \u03c4\u03b5\u03c3\u03c4\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7\u03c2, \u03b5\u03bd\u03c4\u03bf\u03cd\u03c4\u03bf\u03b9\u03c2, \u03ba\u03b1\u03bd\u03ad\u03bd\u03b1\u03c2 \u03bf\u03c1\u03bc\u03bf\u03bd\u03b9\u03ba\u03cc\u03c2 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc\u03c2 \u03b4\u03b5\u03bd \u03ba\u03c1\u03af\u03b8\u03b7\u03ba\u03b5 \u03ad\u03c4\u03bf\u03b9\u03bc\u03bf\u03c2 \u03b3\u03b9\u03b1 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c7\u03c1\u03ae\u03c3\u03b7, \u03ba\u03b1\u03b8\u03ce\u03c2 \u03bf\u03b9 \u03c5\u03c6\u03b9\u03c3\u03c4\u03ac\u03bc\u03b5\u03bd\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c3\u03c4\u03b5\u03c1\u03bf\u03cd\u03bd\u03c4\u03b1\u03bd \u03c4\u03b7\u03c2 \u03b1\u03c0\u03b1\u03b9\u03c4\u03bf\u03cd\u03bc\u03b5\u03bd\u03b7\u03c2 \u03b9\u03c3\u03c7\u03cd\u03bf\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03bd\u03af\u03c7\u03bd\u03b5\u03c5\u03c3\u03b7 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ce\u03bd \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03ce\u03bd \u03ba\u03b1\u03b9 \u03b5\u03af\u03c7\u03b1\u03bd \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5\u03b8\u03bf\u03b4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03c0\u03c1\u03bf\u03b2\u03bb\u03ae\u03bc\u03b1\u03c4\u03b1.<sup>63<\/sup><\/p>\n<h6 style=\"text-align: justify;\">3.4.4. \u0391\u03bd\u03b5\u03c0\u03b9\u03b8\u03cd\u03bc\u03b7\u03c4\u03b5\u03c2 \u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2<\/h6>\n<p style=\"text-align: justify;\">\u0397 \u03c3\u03c5\u03b3\u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03c0\u03c1\u03bf\u03b3\u03b5\u03c3\u03c4\u03b1\u03b3\u03cc\u03bd\u03c9\u03bd \u03bc\u03b1\u03b6\u03af \u03bc\u03b5 \u03b1\u03bd\u03b4\u03c1\u03bf\u03b3\u03cc\u03bd\u03b1 \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03ad\u03c7\u03b5\u03b9 \u03b4\u03c5\u03c3\u03bc\u03b5\u03bd\u03ae \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c3\u03c4\u03bf \u03c3\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc \u03b2\u03ac\u03c1\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd HDL \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b7 \u03bc\u03b5 \u03b1\u03c5\u03c4\u03ae\u03bd \u03c4\u03b7\u03c2 \u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03b9\u03c3\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7\u03c2 \u03b1\u03bd\u03b4\u03c1\u03bf\u03b3\u03cc\u03bd\u03c9\u03bd. \u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03c3\u03b5 \u03b1\u03c5\u03c4\u03ae\u03bd \u03c4\u03b7\u03bd \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03b7 \u03bf\u03b4\u03cc\u03c2 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03c0\u03c1\u03bf\u03b3\u03b5\u03c3\u03c4\u03b1\u03b3\u03cc\u03bd\u03bf\u03c5 \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03b4\u03b9\u03b1\u03b4\u03c1\u03b1\u03bc\u03b1\u03c4\u03af\u03b6\u03b5\u03b9 \u03c3\u03c0\u03bf\u03c5\u03b4\u03b1\u03af\u03bf \u03c1\u03cc\u03bb\u03bf. \u0388\u03c4\u03c3\u03b9, \u03b5\u03bd\u03ce \u03b7 \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5 \u03c3\u03c4\u03cc\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03c3\u03c5\u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c0\u03c1\u03bf-\u03b1\u03b8\u03b7\u03c1\u03bf\u03b3\u03cc\u03bd\u03bf \u03b4\u03c1\u03ac\u03c3\u03b7, \u03b7 \u03b4\u03b9\u03b1\u03b4\u03b5\u03c1\u03bc\u03b9\u03ba\u03ae \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 (\u03b5\u03bc\u03c6\u03c5\u03c4\u03b5\u03cd\u03bc\u03b1\u03c4\u03b1) \u03b4\u03b5 \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03b5\u03b9 \u03c4\u03b7 \u03c3\u03c5\u03b3\u03ba\u03ad\u03bd\u03c4\u03c1\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 HDL, \u03c0\u03b9\u03b8\u03b1\u03bd\u03ce\u03c2 \u03b5\u03be\u03b1\u03b9\u03c4\u03af\u03b1\u03c2 \u03c0\u03b1\u03c1\u03ac\u03ba\u03b1\u03bc\u03c8\u03ae\u03c2 \u03c4\u03bf\u03c5 \u03b7\u03c0\u03b1\u03c4\u03b9\u03ba\u03bf\u03cd \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03c3\u03bc\u03bf\u03cd.<sup>4<\/sup> \u03a3\u03c4\u03b9\u03c2 \u03b3\u03c5\u03bd\u03b1\u03af\u03ba\u03b5\u03c2 \u03b7 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03c0\u03c1\u03bf\u03b3\u03b5\u03c3\u03c4\u03b1\u03b3\u03cc\u03bd\u03c9\u03bd \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03bf\u03c5\u03c2 \u03c3\u03c7\u03b5\u03c4\u03b9\u03b6\u03cc\u03bc\u03b5\u03bd\u03bf\u03c5\u03c2 \u03bc\u03b5 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ae \u03bd\u03cc\u03c3\u03bf \u03b4\u03b5\u03af\u03ba\u03c4\u03b5\u03c2 \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ae\u03c2 (IL-6, C-\u03b1\u03bd\u03c4\u03b9\u03b4\u03c1\u03ce\u03c3\u03b1 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7), \u03c9\u03c3\u03c4\u03cc\u03c3\u03bf \u03c3\u03c4\u03bf\u03bd \u03ac\u03bd\u03b4\u03c1\u03b1, \u03bb\u03cc\u03b3\u03c9 \u03c4\u03b7\u03c2 \u03c0\u03bf\u03bb\u03cd \u03bc\u03b9\u03ba\u03c1\u03cc\u03c4\u03b5\u03c1\u03b7\u03c2 \u03b5\u03bc\u03c0\u03b5\u03b9\u03c1\u03af\u03b1\u03c2 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03bf\u03c5 \u03bc\u03b9\u03ba\u03c1\u03bf\u03cd \u03bc\u03b5\u03b3\u03ad\u03b8\u03bf\u03c5\u03c2 \u03c4\u03c9\u03bd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ce\u03bd \u03bc\u03b5\u03bb\u03b5\u03c4\u03ce\u03bd, \u03c4\u03b1 \u03b4\u03b9\u03b1\u03b8\u03ad\u03c3\u03b9\u03bc\u03b1 \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1 \u03b4\u03b5\u03bd \u03b5\u03c0\u03b1\u03c1\u03ba\u03bf\u03cd\u03bd \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b5\u03be\u03b1\u03b3\u03c9\u03b3\u03ae \u03b1\u03c3\u03c6\u03b1\u03bb\u03ce\u03bd \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b1\u03c3\u03bc\u03ac\u03c4\u03c9\u03bd.<sup>44<\/sup> \u0397 \u03c3\u03c5\u03b3\u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03c0\u03c1\u03bf\u03b3\u03b5\u03c3\u03c4\u03b1\u03b3\u03cc\u03bd\u03bf\u03c5 \u03c3\u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03b1\u03b3\u03c9\u03b3\u03ae \u03b4\u03b5 \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03b5\u03b9 \u03c4\u03bf \u03c7\u03c1\u03cc\u03bd\u03bf \u03c0\u03bf\u03c5 \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03c0\u03bf\u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7\u03c2.<sup>46<\/sup><\/p>\n<h6 style=\"text-align: justify;\">3.5. \u0395\u03bd\u03b1\u03bb\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ac \u03c3\u03c7\u03ae\u03bc\u03b1\u03c4\u03b1<\/h6>\n<p style=\"text-align: justify;\">\u039f\u03b9 \u03c6\u03cc\u03b2\u03bf\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03b9\u03c2 \u03c0\u03b9\u03b8\u03b1\u03bd\u03ad\u03c2 \u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c4\u03b7\u03c2 \u03bc\u03b1\u03ba\u03c1\u03bf\u03c7\u03c1\u03cc\u03bd\u03b9\u03b1\u03c2 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7\u03c2 \u03b1\u03bd\u03b4\u03c1\u03bf\u03b3\u03cc\u03bd\u03c9\u03bd \u03c3\u03c4\u03bf\u03bd \u03c0\u03c1\u03bf\u03c3\u03c4\u03ac\u03c4\u03b7 \u03bf\u03b4\u03ae\u03b3\u03b7\u03c3\u03b1\u03bd \u03c3\u03c4\u03b7 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae \u03b5\u03bd\u03b1\u03bb\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ce\u03bd \u03b1\u03bd\u03c4\u03b9\u03c3\u03c5\u03bb\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03ce\u03bd \u03c3\u03c7\u03b7\u03bc\u03ac\u03c4\u03c9\u03bd.<\/p>\n<p style=\"text-align: justify;\">\u039c\u03b9\u03b1 \u03c0\u03c1\u03bf\u03c3\u03ad\u03b3\u03b3\u03b9\u03c3\u03b7 \u03c0\u03bf\u03c5 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b4\u03b9\u03b1\u03c4\u03b7\u03c1\u03b5\u03af \u03c4\u03b7\u03bd \u03b1\u03bd\u03c4\u03b9\u03c3\u03c5\u03bb\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03ae \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03bc\u03b5 \u03bf\u03c5\u03b4\u03ad\u03c4\u03b5\u03c1\u03b7 \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c3\u03c4\u03bf\u03bd \u03c0\u03c1\u03bf\u03c3\u03c4\u03ac\u03c4\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc\u03c2 \u03c4\u03b7\u03c2 \u03c4\u03b5\u03c3\u03c4\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7\u03c2 \u03bc\u03b5 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03c4\u03b7\u03c2 5\u03b1-\u03b1\u03bd\u03b1\u03b3\u03c9\u03b3\u03ac\u03c3\u03b7\u03c2. \u039c\u03ac\u03bb\u03b9\u03c3\u03c4\u03b1, \u03b7 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03b1 \u03c4\u03b7\u03c2 5\u03b1-\u03b1\u03bd\u03b1\u03b3\u03c9\u03b3\u03ac\u03c3\u03b7\u03c2 \u03b8\u03b1 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03c3\u03b5 \u03bd\u03b1 \u03b2\u03b5\u03bb\u03c4\u03b9\u03ce\u03c3\u03b5\u03b9 \u03c0\u03b5\u03c1\u03b1\u03b9\u03c4\u03ad\u03c1\u03c9 \u03c4\u03b7\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03b2\u03b1\u03c3\u03b9\u03b6\u03cc\u03bc\u03b5\u03bd\u03b7\u03c2 \u03c3\u03c4\u03b1 \u03b1\u03bd\u03b4\u03c1\u03bf\u03b3\u03cc\u03bd\u03b1 \u03b1\u03bd\u03c4\u03b9\u03c3\u03c5\u03bb\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b1\u03b3\u03c9\u03b3\u03ae\u03c2 \u03b1\u03c6\u03bf\u03cd \u03c4\u03b1 \u03b5\u03bd\u03b4\u03bf-\u03bf\u03c1\u03c7\u03b9\u03ba\u03ac \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03b4\u03b9\u03cb\u03b4\u03c1\u03bf-\u03c4\u03b5\u03c3\u03c4\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7\u03c2 (DHT) \u03b1\u03c5\u03be\u03ac\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c9\u03c2 \u03b1\u03c0\u03ac\u03bd\u03c4\u03b7\u03c3\u03b7 \u03c3\u03c4\u03b7\u03bd \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03b7\u03c2 \u03b5\u03bd\u03b4\u03bf\u03b3\u03b5\u03bd\u03bf\u03cd\u03c2 \u03c4\u03b5\u03c3\u03c4\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7\u03c2, \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03b4\u03c5\u03c3\u03c7\u03ad\u03c1\u03b5\u03b9\u03b1 \u03c3\u03c4\u03b7\u03bd \u03c0\u03bb\u03ae\u03c1\u03b7 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03b7\u03c2 \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7\u03c2 \u03c0\u03b1\u03c1\u03ac \u03c4\u03b7\u03bd \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03bf\u03b9\u03c7\u03b7 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03c9\u03bd \u03b3\u03bf\u03bd\u03b1\u03b4\u03bf\u03c4\u03c1\u03bf\u03c0\u03b9\u03bd\u03ce\u03bd. \u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03b1\u03c5\u03c4\u03cc \u03c4\u03b5\u03bb\u03b9\u03ba\u03ac \u03b4\u03b5\u03bd \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03b9\u03ce\u03b8\u03b7\u03ba\u03b5 \u03c3\u03c4\u03b9\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c3\u03c4\u03b9\u03c2 \u03bf\u03c0\u03bf\u03af\u03b5\u03c2 \u03c3\u03c5\u03b3\u03c7\u03bf\u03c1\u03b7\u03b3\u03ae\u03b8\u03b7\u03ba\u03b5 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03b1\u03c2 \u03c4\u03b7\u03c2 5\u03b1-\u03b1\u03bd\u03b1\u03b3\u03c9\u03b3\u03ac\u03c3\u03b7\u03c2 \u03bc\u03b5 \u03c4\u03b5\u03c3\u03c4\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7, \u03b1\u03c6\u03bf\u03cd \u03b4\u03b5\u03bd \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03ae\u03b8\u03b7\u03ba\u03b5 \u03b2\u03b5\u03bb\u03c4\u03af\u03c9\u03c3\u03b7 \u03c3\u03c4\u03b7\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2 \u03c4\u03b7\u03c2 \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7\u03c2.<sup>64<\/sup><\/p>\n<p style=\"text-align: justify;\">\u03a3\u03c4\u03b7\u03bd \u03ba\u03b1\u03c4\u03b5\u03cd\u03b8\u03c5\u03bd\u03c3\u03b7 \u03b1\u03c5\u03c4\u03ae\u03bd \u03c4\u03b7\u03c2 \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7\u03c2 \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03b5\u03c5\u03c4\u03b9\u03ba\u03ce\u03bd \u03bf\u03c5\u03c3\u03b9\u03ce\u03bd \u03c0\u03bf\u03c5 \u03b8\u03b1 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03c3\u03b1\u03bd \u03bd\u03b1 \u03b4\u03b9\u03b1\u03c4\u03b7\u03c1\u03bf\u03cd\u03bd \u03c4\u03b7\u03c2 \u03b8\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b1\u03bd\u03b4\u03c1\u03bf\u03b3\u03bf\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c3\u03c4\u03b7 \u03c3\u03cd\u03c3\u03c4\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c3\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2, \u03c4\u03b1 \u03bf\u03c3\u03c4\u03ac, \u03c4\u03b7\u03bd \u03b1\u03b9\u03bc\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03ba.\u03b1. \u03c7\u03c9\u03c1\u03af\u03c2 \u03bd\u03b1 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03bf\u03c5\u03bd \u03c4\u03b9\u03c2 \u03b4\u03c5\u03c3\u03bc\u03b5\u03bd\u03b5\u03af\u03c2 \u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c3\u03c4\u03bf \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03c3\u03bc\u03cc \u03ba\u03b1\u03b9 \u03c4\u03bf\u03bd \u03c0\u03c1\u03bf\u03c3\u03c4\u03ac\u03c4\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 \u03b5\u03ba\u03bb\u03b5\u03ba\u03c4\u03b9\u03ba\u03ce\u03bd \u03c4\u03c1\u03bf\u03c0\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03ce\u03bd \u03c4\u03bf\u03c5 \u03b1\u03bd\u03b4\u03c1\u03bf\u03b3\u03bf\u03bd\u03b9\u03ba\u03bf\u03cd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 (Selective Androgen Receptor Modulators \u2013 SARMs).<\/p>\n<p style=\"text-align: justify;\">H 7\u03b1-\u03bc\u03b5\u03b8\u03c5\u03bb\u03bf-19-\u03bd\u03bf\u03c1-\u03c4\u03b5\u03c3\u03c4\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7 (\u039c\u0395\u039d\u03a4) \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1\u03c2 \u03c3\u03c4\u03b5\u03c1\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03cc\u03c2 SARM, \u03b7 \u03bc\u03b5\u03b8\u03c5\u03bb\u03af\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03bf\u03c0\u03bf\u03af\u03bf\u03c5 \u03c3\u03c4\u03b7 \u03b8\u03ad\u03c3\u03b7 7 \u03b1\u03c0\u03bf\u03c4\u03c1\u03ad\u03c0\u03b5\u03b9 \u03c4\u03b7\u03bd 5 &#8211; \u03b1\u03bd\u03b1\u03b3\u03c9\u03b3\u03ae, \u03bf\u03c5\u03c3\u03b9\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03b5\u03bb\u03b1\u03c7\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7 \u03bc\u03b5\u03c4\u03b1\u03c4\u03c1\u03bf\u03c0\u03ae \u03c4\u03b7\u03c2 \u03c3\u03b5 DHT \u03ba\u03b1\u03b9 \u03c4\u03b9\u03c2 \u03b5\u03c0\u03b1\u03ba\u03cc\u03bb\u03bf\u03c5\u03b8\u03b5\u03c2 \u03b4\u03c5\u03c3\u03bc\u03b5\u03bd\u03b5\u03af\u03c2 \u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c3\u03c4\u03bf\u03bd \u03c0\u03c1\u03bf\u03c3\u03c4\u03ac\u03c4\u03b7.<sup>65<\/sup> \u0397 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u039c\u0395\u039d\u03a4 \u03ad\u03c7\u03b5\u03b9 \u03c9\u03c2 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03b7\u03bd \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03c9\u03bd \u03b3\u03bf\u03bd\u03b1\u03b4\u03bf\u03c4\u03c1\u03bf\u03c0\u03b9\u03bd\u03ce\u03bd \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03bf\u03cd\u03c3\u03b7\u03c2 \u03c4\u03b5\u03c3\u03c4\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7\u03c2 \u03ba\u03b1\u03c4\u03ac 80 -90%, \u03b5\u03bd\u03ce \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c9\u03c2 \u03bc\u03bf\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 \u03c4\u03b7 \u03bc\u03bf\u03c1\u03c6\u03ae \u03b5\u03bc\u03c6\u03c5\u03c4\u03b5\u03c5\u03bc\u03ac\u03c4\u03c9\u03bd \u03c3\u03b5 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03b1\u03bd\u03c4\u03b9\u03c3\u03cd\u03bb\u03bb\u03b7\u03c8\u03b7\u03c2 \u03bf\u03b4\u03ae\u03b3\u03b7\u03c3\u03b5 \u03c3\u03b5 \u03b1\u03b6\u03c9\u03bf\u03c3\u03c0\u03b5\u03c1\u03bc\u03af\u03b1 \u03c3\u03c4\u03bf 73% \u03c4\u03c9\u03bd \u03b1\u03bd\u03b4\u03c1\u03ce\u03bd.<sup>66<\/sup> \u0391\u03c4\u03c5\u03c7\u03ce\u03c2, \u03c4\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03b1\u03c5\u03c4\u03ac \u03b5\u03af\u03c7\u03b1\u03bd \u03c3\u03cd\u03bd\u03c4\u03bf\u03bc\u03b7 \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1, \u03c0\u03b9\u03b8\u03b1\u03bd\u03ce\u03c2 \u03bb\u03cc\u03b3\u03c9 \u03c4\u03b7\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03bf\u03cd\u03c2 \u03c3\u03cd\u03bd\u03b4\u03b5\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u039c\u0395\u039d\u03a4 \u03bc\u03b5 \u03c4\u03b7\u03bd SHBG \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03c3\u03c5\u03bd\u03b1\u03ba\u03cc\u03bb\u03bf\u03c5\u03b8\u03b7\u03c2 \u03bc\u03b9\u03ba\u03c1\u03ae\u03c2 \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1\u03c2 \u03b7\u03bc\u03b9\u03b6\u03c9\u03ae\u03c2 \u03c3\u03c4\u03b7\u03bd \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03af\u03b1.<\/p>\n<p style=\"text-align: justify;\">\u0391\u03bd\u03ac\u03bb\u03bf\u03b3\u03b5\u03c2 \u03bf\u03c5\u03c3\u03af\u03b5\u03c2 \u03cc\u03c0\u03c9\u03c2 \u03b7 \u03b4\u03b5\u03c3\u03bf\u03be\u03c5-\u03bc\u03b5\u03b8\u03c5\u03bb-\u03c4\u03b5\u03c3\u03c4\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7 \u03ba\u03b1\u03b9 \u03b7 \u03c4\u03b5\u03c4\u03c1\u03b1\u03cb\u03b4\u03c1\u03bf\u03b3\u03b5\u03c3\u03c4\u03b9\u03bd\u03cc\u03bd\u03b7 \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03b4\u03b9\u03b1\u03c4\u03b7\u03c1\u03bf\u03cd\u03bd \u03b8\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b1\u03bd\u03b4\u03c1\u03bf\u03b3\u03bf\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c3\u03b5 \u03c0\u03b5\u03b9\u03c1\u03b1\u03bc\u03b1\u03c4\u03cc\u03b6\u03c9\u03b1 \u03c7\u03c9\u03c1\u03af\u03c2 \u03bd\u03b1 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03bf\u03c5\u03bd \u03c4\u03bf\u03bd \u03c0\u03c1\u03bf\u03c3\u03c4\u03ac\u03c4\u03b7, \u03b5\u03bd\u03ce \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c0\u03b1\u03c1\u03b1\u03bd\u03cc\u03bc\u03c9\u03c2 \u03c3\u03c4\u03b1 \u03c0\u03bb\u03b1\u03af\u03c3\u03b9\u03b1 \u03b2\u03b5\u03bb\u03c4\u03af\u03c9\u03c3\u03b7\u03c2 \u03b1\u03b8\u03bb\u03b7\u03c4\u03b9\u03ba\u03ce\u03bd \u03b5\u03c0\u03b9\u03b4\u03cc\u03c3\u03b5\u03c9\u03bd. \u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03b4\u03b5\u03bd \u03ad\u03c7\u03bf\u03c5\u03bd \u03b4\u03bf\u03ba\u03b9\u03bc\u03b1\u03c3\u03c4\u03b5\u03af \u03c9\u03c2 \u03c4\u03ce\u03c1\u03b1 \u03c9\u03c2 \u03bc\u03ad\u03c3\u03b1 \u03b1\u03bd\u03c4\u03b9\u03c3\u03cd\u03bb\u03bb\u03b7\u03c8\u03b7\u03c2. \u0391\u03bd\u03c4\u03af\u03c3\u03c4\u03bf\u03b9\u03c7\u03b1, \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c0\u03c1\u03bf\u03c3\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1 \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7\u03c2 \u03bc\u03b7 \u03c3\u03c4\u03b5\u03c1\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd SARMs, \u03bf\u03b9 \u03bf\u03c0\u03bf\u03af\u03bf\u03b9 \u03b8\u03b1 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03c3\u03b1\u03bd \u03bd\u03b1 \u03c7\u03bf\u03c1\u03b7\u03b3\u03b7\u03b8\u03bf\u03cd\u03bd \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5 \u03c3\u03c4\u03cc\u03bc\u03b1\u03c4\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bf\u03c5\u03bd \u03c4\u03b7 \u03b2\u03ac\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 \u03b5\u03bd\u03cc\u03c2 \u03b1\u03bd\u03b4\u03c1\u03b9\u03ba\u03bf\u03cd \u03b1\u03bd\u03c4\u03b9\u03c3\u03c5\u03bb\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03bf\u03cd \u03c7\u03b1\u03c0\u03b9\u03bf\u03cd.<sup>67<\/sup><\/p>\n<h5 style=\"text-align: justify;\">3.6. \u0395\u03c1\u03c9\u03c4\u03ae\u03bc\u03b1\u03c4\u03b1<\/h5>\n<h6 style=\"text-align: justify;\">3.6.1. \u0393\u03b9\u03b1\u03c4\u03af \u03b7 \u03bf\u03c1\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03b1\u03bd\u03c4\u03b9\u03c3\u03cd\u03bb\u03bb\u03b7\u03c8\u03b7 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c3\u03b5 \u03cc\u03bb\u03bf\u03c5\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03ac\u03bd\u03b4\u03c1\u03b5\u03c2;<\/h6>\n<p style=\"text-align: justify;\">\u03a4\u03bf \u03b3\u03b5\u03b3\u03bf\u03bd\u03cc\u03c2 \u03cc\u03c4\u03b9 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03b9 \u03ac\u03bd\u03b4\u03c1\u03b5\u03c2 \u03b4\u03b5\u03bd \u03b1\u03bd\u03c4\u03b1\u03c0\u03bf\u03ba\u03c1\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03bf\u03c1\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03b1\u03bd\u03c4\u03b9\u03c3\u03cd\u03bb\u03bb\u03b7\u03c8\u03b7 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03ad\u03bd\u03b1 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03b5\u03c1\u03ce\u03c4\u03b7\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03b5\u03bd\u03b4\u03b5\u03c7\u03bf\u03bc\u03ad\u03bd\u03c9\u03c2 \u03b5\u03bc\u03c0\u03cc\u03b4\u03b9\u03bf \u03c3\u03c4\u03b7\u03bd \u03c0\u03b5\u03c1\u03b1\u03b9\u03c4\u03ad\u03c1\u03c9 \u03b5\u03bc\u03c0\u03bf\u03c1\u03b9\u03ba\u03ae \u03b5\u03ba\u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b5\u03c5\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b4\u03b9\u03b1\u03c6\u03cc\u03c1\u03c9\u03bd \u03bc\u03b5\u03b8\u03cc\u03b4\u03c9\u03bd. \u03a4\u03b1 \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03ac \u03c4\u03c9\u03bd \u03bc\u03b7 \u03b1\u03bd\u03c4\u03b1\u03c0\u03bf\u03ba\u03c1\u03b9\u03bd\u03cc\u03bc\u03b5\u03bd\u03c9\u03bd \u03b1\u03bd\u03b4\u03c1\u03ce\u03bd (non-responders) \u03c3\u03c4\u03b9\u03c2 \u03b4\u03b9\u03ac\u03c6\u03bf\u03c1\u03b5\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03ba\u03c5\u03bc\u03b1\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc 5 \u03c9\u03c2 \u03ba\u03b1\u03b9 20%. \u0388\u03c9\u03c2 \u03c4\u03ce\u03c1\u03b1 \u03b4\u03b5\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03b1\u03c3\u03c6\u03b1\u03bb\u03ae\u03c2 \u03c4\u03c1\u03cc\u03c0\u03bf\u03c2 \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03c0\u03c1\u03bf\u03b2\u03bb\u03b5\u03c6\u03b8\u03b5\u03af \u03c0\u03bf\u03b9\u03bf\u03b9 \u03ac\u03bd\u03b4\u03c1\u03b5\u03c2 \u03b4\u03b5\u03bd \u03b8\u03b1 \u03b1\u03bd\u03c4\u03b1\u03c0\u03bf\u03ba\u03c1\u03b9\u03b8\u03bf\u03cd\u03bd \u03ba\u03b1\u03b8\u03ce\u03c2 \u03bf\u03b9 \u03bc\u03b7-\u03b1\u03bd\u03c4\u03b1\u03c0\u03bf\u03ba\u03c1\u03b9\u03bd\u03cc\u03bc\u03b5\u03bd\u03bf\u03b9 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c4\u03b1 \u03af\u03b4\u03b9\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03b3\u03bf\u03bd\u03b1\u03b4\u03bf\u03c4\u03c1\u03bf\u03c0\u03b9\u03bd\u03ce\u03bd \u03ba\u03b1\u03b9 \u03c4\u03b5\u03c3\u03c4\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7\u03c2, \u03cc\u03c0\u03c9\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf-\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ce\u03bd \u03c3\u03c5\u03b3\u03ba\u03b5\u03bd\u03c4\u03c1\u03ce\u03c3\u03b5\u03c9\u03bd \u03c3\u03c0\u03ad\u03c1\u03bc\u03b1\u03c4\u03bf\u03c2 \u03bc\u03b5 \u03cc\u03c3\u03bf\u03c5\u03c2 \u03b1\u03bd\u03c4\u03b1\u03c0\u03bf\u03ba\u03c1\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9.<sup>68, 69<\/sup> \u0395\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd, \u03b7 \u03b1\u03bd\u03b5\u03cd\u03c1\u03b5\u03c3\u03b7 \u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03c9\u03bd \u03b5\u03c0\u03b9\u03c0\u03ad\u03b4\u03c9\u03bd 5\u03b1-\u03b1\u03bd\u03b1\u03b3\u03c9\u03b3\u03ac\u03c3\u03b7\u03c2 \u03c3\u03c4\u03bf\u03c5\u03c2 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\u03b5\u03c0\u03af\u03c4\u03b5\u03c5\u03be\u03b7\u03c2 \u03b1\u03b6\u03c9\u03bf\u03c3\u03c0\u03b5\u03c1\u03bc\u03af\u03b1\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5\u03c2 \u039a\u03b1\u03c5\u03ba\u03ac\u03c3\u03b9\u03bf\u03c5\u03c2.<sup>69<\/sup> \u0388\u03c4\u03c3\u03b9, \u03bc\u03bf\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 \u03c4\u03b5\u03c3\u03c4\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03ad\u03c3\u03b5\u03b9 \u03b1\u03b6\u03c9\u03bf\u03c3\u03c0\u03b5\u03c1\u03bc\u03af\u03b1 \u03bc\u03cc\u03bd\u03bf \u03c3\u03c4\u03b1 \u03b4\u03cd\u03bf &#8211; \u03c4\u03c1\u03af\u03c4\u03b1 \u03c4\u03c9\u03bd \u039a\u03b1\u03c5\u03ba\u03ac\u03c3\u03b9\u03c9\u03bd \u03b1\u03bd\u03b4\u03c1\u03ce\u03bd.<sup>9<\/sup> \u039c\u03ad\u03c7\u03c1\u03b9 \u03c4\u03ce\u03c1\u03b1 \u03b4\u03b5\u03bd \u03ad\u03c7\u03bf\u03c5\u03bd \u03b2\u03c1\u03b5\u03b8\u03b5\u03af \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03ad\u03c2 \u03c0\u03bf\u03c5 \u03bd\u03b1 \u03b5\u03be\u03b7\u03b3\u03bf\u03cd\u03bd \u03b1\u03c5\u03c4\u03ae \u03c4\u03b7 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7. \u039c\u03af\u03b1 \u03c0\u03b9\u03b8\u03b1\u03bd\u03ae \u03b5\u03be\u03ae\u03b3\u03b7\u03c3\u03b7 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03bf \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03c3\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03bf\u03cd \u03bb\u03af\u03c0\u03bf\u03c5\u03c2 \u03c0\u03bf\u03c5 \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03af\u03b6\u03b5\u03b9 \u03c4\u03bf\u03c5\u03c2 \u0391\u03c3\u03b9\u03ac\u03c4\u03b5\u03c2, \u03b5\u03c0\u03b9\u03c4\u03c1\u03ad\u03c0\u03bf\u03bd\u03c4\u03b1\u03c2 \u03ad\u03c4\u03c3\u03b9 \u03c3\u03c4\u03b9\u03c2 \u03af\u03b4\u03b9\u03b5\u03c2 \u03b4\u03cc\u03c3\u03b5\u03b9\u03c2 \u03b1\u03bd\u03b4\u03c1\u03bf\u03b3\u03cc\u03bd\u03c9\u03bd \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b9\u03bf \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ad\u03c2.<\/p>\n<h4 style=\"text-align: justify;\">4. \u039c\u03b7 \u03bf\u03c1\u03bc\u03bf\u03bd\u03b9\u03ba\u03ad\u03c2 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf\u03b9 \u03b1\u03bd\u03c4\u03b9\u03c3\u03cd\u03bb\u03bb\u03b7\u03c8\u03b7\u03c2<\/h4>\n<p style=\"text-align: justify;\">\u039f\u03b9 \u03bc\u03b7 \u03bf\u03c1\u03bc\u03bf\u03bd\u03b9\u03ba\u03ad\u03c2 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf\u03b9 \u03b1\u03bd\u03c4\u03b9\u03c3\u03cd\u03bb\u03bb\u03b7\u03c8\u03b7\u03c2 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03bf\u03cd\u03bd \u03c4\u03bf \u03c0\u03b9\u03bf \u03c5\u03c0\u03bf\u03c3\u03c7\u03cc\u03bc\u03b5\u03bd\u03bf \u03c0\u03b5\u03b4\u03af\u03bf \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1\u03c2 \u03c3\u03c4\u03b7\u03bd \u03b1\u03bd\u03b4\u03c1\u03b9\u03ba\u03ae \u03b1\u03bd\u03c4\u03b9\u03c3\u03cd\u03bb\u03bb\u03b7\u03c8\u03b7, \u03ba\u03b1\u03b8\u03ce\u03c2 \u03bf\u03b9 \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03b4\u03b9\u03b5\u03c1\u03b3\u03b1\u03c3\u03af\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03c3\u03c4\u03bf\u03c7\u03b5\u03cd\u03bf\u03c5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b9\u03bf \u03b5\u03c0\u03b9\u03ba\u03b5\u03bd\u03c4\u03c1\u03c9\u03bc\u03ad\u03bd\u03b5\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03c2 \u03bf\u03c1\u03bc\u03bf\u03bd\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03b8\u03cc\u03b4\u03bf\u03c5\u03c2 \u03ba\u03b1\u03b9 \u03c9\u03c2 \u03b5\u03ba \u03c4\u03bf\u03cd\u03c4\u03bf\u03c5 \u03b5\u03af\u03bd\u03b1\u03b9, \u03b8\u03b5\u03c9\u03c1\u03b7\u03c4\u03b9\u03ba\u03ac \u03c4\u03bf\u03c5\u03bb\u03ac\u03c7\u03b9\u03c3\u03c4\u03bf\u03bd, \u03b5\u03c6\u03b9\u03ba\u03c4\u03ae \u03b7 \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03b9\u03ce\u03bd \u03bc\u03b5 \u03bb\u03b9\u03b3\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03c0\u03b1\u03c1\u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2. \u03a0\u03b1\u03c1\u03cc\u03bb\u03b1 \u03b1\u03c5\u03c4\u03ac, \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b5\u03be\u03b1\u03af\u03c1\u03b5\u03c3\u03b7 \u03bc\u03af\u03b1\u03c2 \u03bf\u03c5\u03c3\u03af\u03b1\u03c2 (gossypol), \u03bf\u03b9 \u03c5\u03c0\u03cc\u03bb\u03bf\u03b9\u03c0\u03b5\u03c2 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf\u03b9 \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03bf\u03c5\u03bd \u03c3\u03b5 \u03c0\u03b5\u03b9\u03c1\u03b1\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03c3\u03c4\u03ac\u03b4\u03b9\u03b1 \u03b1\u03c6\u03bf\u03cd \u03c4\u03cc\u03c3\u03bf \u03c4\u03b1 \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1 \u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03c1\u03b5\u03c8\u03b9\u03bc\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03bf\u03b8\u03b1\u03c1\u03c1\u03c5\u03bd\u03c4\u03b9\u03ba\u03ac. \u039f\u03b9 \u03b4\u03b9\u03ac\u03c6\u03bf\u03c1\u03b5\u03c2 \u03bc\u03b7 \u03bf\u03c1\u03bc\u03bf\u03bd\u03b9\u03ba\u03ad\u03c2 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf\u03b9 \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03b9\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b1\u03c5\u03c4\u03ad\u03c2 \u03c0\u03bf\u03c5 \u03c3\u03c4\u03bf\u03c7\u03b5\u03cd\u03bf\u03c5\u03bd \u03b1) \u03c4\u03b7\u03bd \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b2) \u03c4\u03b7 \u03bc\u03b5\u03c4\u03b1\u03c6\u03bf\u03c1\u03ac \u03ba\u03b1\u03b9 \u03c9\u03c1\u03af\u03bc\u03b1\u03bd\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b6\u03c9\u03b1\u03c1\u03af\u03c9\u03bd \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03b4\u03b9\u03b4\u03c5\u03bc\u03af\u03b4\u03b1.<\/p>\n<h5 style=\"text-align: justify;\">4.1. \u0391\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7\u03c2<\/h5>\n<h6 style=\"text-align: justify;\">4.1.1. \u03a7\u03b7\u03bc\u03b9\u03ba\u03ad\u03c2 \u2013 \u03a6\u03b1\u03c1\u03bc\u03b1\u03ba\u03b5\u03c5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf\u03b9<\/h6>\n<p style=\"text-align: justify;\">\u0391\u03bd \u03ba\u03b1\u03b9 \u03bc\u03af\u03b1 \u03c0\u03bb\u03b7\u03b8\u03ce\u03c1\u03b1 \u03c7\u03b7\u03bc\u03b9\u03ba\u03ce\u03bd \u03bf\u03c5\u03c3\u03b9\u03ce\u03bd \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03b5\u03af\u03bb\u03bf\u03c5\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03c4\u03b7 \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7, \u03bf\u03b9 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03b1\u03c0\u03cc \u03b1\u03c5\u03c4\u03ad\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf\u03be\u03b9\u03ba\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03ac \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03bf\u03cd\u03bd \u03bc\u03b7 \u03b1\u03bd\u03b1\u03c3\u03c4\u03c1\u03ad\u03c8\u03b9\u03bc\u03b7 \u03c3\u03c4\u03b5\u03b9\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1. \u0394\u03c1\u03bf\u03c5\u03bd \u03c3\u03c4\u03b1\u00a0\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 Sertoli \u03ae \u03c3\u03c4\u03b1 \u03b3\u03b5\u03bd\u03bd\u03b7\u03c4\u03b9\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03ae \u03c3\u03c4\u03b9\u03c2 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03c4\u03bf\u03c5\u03c2 \u03c3\u03c5\u03bd\u03b4\u03ad\u03c3\u03b5\u03b9\u03c2, \u03b5\u03bd\u03ce \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03c3\u03c4\u03cc\u03c7\u03b5\u03c5\u03c3\u03b7 \u03c4\u03c9\u03bd \u03bc\u03b5\u03c4\u03b1-\u03bc\u03b5\u03b9\u03c9\u03c4\u03b9\u03ba\u03ce\u03bd \u03c3\u03c4\u03b1\u03b4\u03af\u03c9\u03bd \u03c4\u03b7\u03c2 \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03b1\u03c1\u03b1\u03af\u03c4\u03b7\u03c4\u03bf \u03bf\u03b9 \u03bf\u03c5\u03c3\u03af\u03b5\u03c2 \u03b1\u03c5\u03c4\u03ad\u03c2 \u03bd\u03b1 \u03b4\u03b9\u03ad\u03c1\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c4\u03bf\u03bd \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf-\u03bf\u03c1\u03c7\u03b9\u03ba\u03cc \u03c6\u03c1\u03b1\u03b3\u03bc\u03cc.<sup>73<\/sup><\/p>\n<p style=\"text-align: justify;\"><b>\u0393\u03ba\u03bf\u03c3\u03c3\u03c5\u03c0\u03cc\u03bb\u03b7 \u2013 \u03a4\u03c1\u03b9\u03c0\u03c4\u03bf\u03bb\u03af\u03b4\u03b7. <\/b>\u03a0\u03c1\u03cc\u03ba\u03b5\u03b9\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c6\u03c5\u03c4\u03b9\u03ba\u03ac \u03b5\u03ba\u03c7\u03c5\u03bb\u03af\u03c3\u03bc\u03b1\u03c4\u03b1 \u03c4\u03b1 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03ae\u03b8\u03b7\u03ba\u03b1\u03bd \u03b1\u03bc\u03c6\u03cc\u03c4\u03b5\u03c1\u03b1 \u03c3\u03c4\u03b7\u03bd \u039a\u03af\u03bd\u03b1. \u0397 \u03b3\u03ba\u03bf\u03c3\u03c3\u03c5\u03c0\u03cc\u03bb\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c6\u03b1\u03b9\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u03ad\u03bd\u03c9\u03c3\u03b7, \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c0\u03c1\u03bf\u03ad\u03c1\u03c7\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf \u03c3\u03c0\u03cc\u03c1\u03bf \u03c4\u03bf\u03c5 \u03b2\u03b1\u03bc\u03b2\u03b1\u03ba\u03b9\u03bf\u03cd \u03ba\u03b1\u03b9 \u03b7 \u03c7\u03c1\u03ae\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c3\u03c4\u03b7\u03bd \u03b1\u03bd\u03b4\u03c1\u03b9\u03ba\u03ae \u03b1\u03bd\u03c4\u03b9\u03c3\u03cd\u03bb\u03bb\u03b7\u03c8\u03b7 \u03c0\u03c1\u03bf\u03ad\u03ba\u03c5\u03c8\u03b5 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03c4\u03ae\u03c1\u03b7\u03c3\u03b7 \u03ba\u03b9\u03bd\u03ad\u03b6\u03c9\u03bd \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03ce\u03bd \u03cc\u03c4\u03b9 \u03ac\u03bd\u03b4\u03c1\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03c3\u03b1\u03bd \u03c3\u03c4\u03b7 \u03b4\u03b9\u03b1\u03c4\u03c1\u03bf\u03c6\u03ae \u03c4\u03bf\u03c5\u03c2 \u03b1\u03ba\u03b1\u03c4\u03ad\u03c1\u03b3\u03b1\u03c3\u03c4\u03bf \u03b2\u03b1\u03bc\u03b2\u03b1\u03ba\u03ad\u03bb\u03b1\u03b9\u03bf \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1\u03b6\u03b1\u03bd \u03b1\u03c3\u03c5\u03bd\u03ae\u03b8\u03b9\u03c3\u03c4\u03b1 \u03c5\u03c8\u03b7\u03bb\u03ac \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03ac \u03c5\u03c0\u03bf\u03b3\u03bf\u03bd\u03b9\u03bc\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2. \u0397 \u03b3\u03ba\u03bf\u03c3\u03c3\u03c5\u03c0\u03cc\u03bb\u03b7 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03b5\u03b9 \u03c4\u03cc\u03c3\u03bf \u03c4\u03b7\u03bd \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7 \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03ba\u03b9\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03c9\u03bd \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b6\u03c9\u03b1\u03c1\u03af\u03c9\u03bd. \u03a3\u03b5 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c3\u03c4\u03b7\u03bd \u039a\u03af\u03bd\u03b1 \u03c3\u03c4\u03b7 \u03b4\u03b5\u03ba\u03b1\u03b5\u03c4\u03af\u03b1 \u03c4\u03bf\u03c5 1980, \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5 \u03c3\u03c4\u03cc\u03bc\u03b1\u03c4\u03bf\u03c2 \u03b3\u03ba\u03bf\u03c3\u03c3\u03c5\u03c0\u03cc\u03bb\u03b7\u03c2\u00a0\u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03b5\u03c5\u03c1\u03b5\u03af\u03b1\u03c2 \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03b9\u03b1\u03ba\u03ae\u03c2 \u03ba\u03bb\u03af\u03bc\u03b1\u03ba\u03b1\u03c2 \u03b5\u03af\u03c7\u03b5 \u03c9\u03c2 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03bf\u03bb\u03b9\u03b3\u03bf\u03b6\u03c9\u03bf\u03c3\u03c0\u03b5\u03c1\u03bc\u03af\u03b1 \u03c4\u03b7\u03c2 \u03c4\u03ac\u03be\u03b7\u03c2 &lt;1 \u03b5\u03ba\u03b1\u03c4\u03bf\u03bc\u03bc\u03cd\u03c1\u03b9\u03bf\/ml \u03c3\u03b5 \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc 90%.<sup>74<\/sup> \u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03c3\u03b5 20 % \u03c4\u03c9\u03bd \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03c9\u03bd \u03b7 \u03b1\u03bd\u03c4\u03b9\u03c3\u03c5\u03bb\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03ae \u03b4\u03c1\u03ac\u03c3\u03b7 \u03ae\u03c4\u03b1\u03bd \u03bc\u03b7 \u03b1\u03bd\u03b1\u03c3\u03c4\u03c1\u03ad\u03c8\u03b9\u03bc\u03b7, \u03b5\u03bd\u03ce \u03c3\u03b5 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03ae\u03b8\u03b7\u03ba\u03b5 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\u03b1\u03bd\u03c4\u03b9\u03c3\u03c5\u03bb\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03ae \u03b4\u03c1\u03ac\u03c3\u03b7 \u03b4\u03b9\u03b1\u03c0\u03b9\u03c3\u03c4\u03ce\u03b8\u03b7\u03ba\u03b5 \u03c3\u03c4\u03b7 \u03b4\u03b5\u03ba\u03b1\u03b5\u03c4\u03af\u03b1 \u03c4\u03bf\u03c5 1980, \u03c9\u03c3\u03c4\u03cc\u03c3\u03bf \u03b4\u03b5 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03ae\u03b8\u03b7\u03ba\u03b5 \u03c9\u03c2 \u03b1\u03bd\u03c4\u03b9\u03c3\u03c5\u03bb\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03cc \u03bb\u03cc\u03b3\u03c9 \u03c4\u03b7\u03c2 \u03bd\u03b5\u03c6\u03c1\u03bf\u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03ac\u03c2 \u03c4\u03bf\u03c5. \u0391\u03bd\u03c4\u03b9\u03b8\u03ad\u03c4\u03c9\u03c2, \u03b7 adjudin \u03c3\u03c4\u03b5\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03c5\u03c4\u03ae\u03c2 \u03c4\u03b7\u03c2 \u03c4\u03bf\u03be\u03b9\u03ba\u03ae\u03c2 \u03b4\u03c1\u03ac\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03b5\u03c0\u03b9\u03c4\u03c5\u03b3\u03c7\u03ac\u03bd\u03b5\u03b9 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ae \u03c4\u03b7\u03c2 \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7\u03c2 \u03c0\u03b1\u03c1\u03b5\u03bc\u03b2\u03b1\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c3\u03c4\u03b9\u03c2 \u03c3\u03c5\u03bd\u03b4\u03ad\u03c3\u03b5\u03b9\u03c2 \u03c4\u03c9\u03bd \u03b3\u03b5\u03bd\u03bd\u03b7\u03c4\u03b9\u03ba\u03ce\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03bc\u03b5 \u03c4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 Sertoli. \u0391\u03c5\u03c4\u03cc \u03ad\u03c7\u03b5\u03b9 \u03c9\u03c2 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03b7\u03bd \u03c0\u03c1\u03cc\u03c9\u03c1\u03b7 \u03b1\u03c0\u03b5\u03bb\u03b5\u03c5\u03b8\u03ad\u03c1\u03c9\u03c3\u03b7 \u03b1\u03bd\u03ce\u03c1\u03b9\u03bc\u03c9\u03bd \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03af\u03b4\u03c9\u03bd \u03bf\u03b9 \u03bf\u03c0\u03bf\u03af\u03b5\u03c2 \u03c3\u03c4\u03b5\u03c1\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b3\u03bf\u03bd\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b9\u03ba\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2. \u0391\u03c0\u03cc \u03c4\u03bf\u03c5 \u03c3\u03c4\u03cc\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03c3\u03b5 \u03b1\u03c1\u03bf\u03c5\u03c1\u03b1\u03af\u03bf\u03c5\u03c2 \u03b5\u03af\u03c7\u03b5 \u03c9\u03c2 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b1\u03bd\u03b1\u03c3\u03c4\u03c1\u03ad\u03c8\u03b9\u03bc\u03b7 \u03c3\u03c4\u03b5\u03b9\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1, \u03c9\u03c3\u03c4\u03cc\u03c3\u03bf \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03ae\u03b8\u03b7\u03ba\u03b1\u03bd \u03c0\u03b1\u03c1\u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2, \u03cc\u03c0\u03c9\u03c2 \u03b7\u03c0\u03b1\u03c4\u03b9\u03ba\u03ae \u03b4\u03c5\u03c3\u03c0\u03c1\u03b1\u03b3\u03af\u03b1 \u03ba\u03b1\u03b9 \u03bc\u03c5\u03ca\u03ba\u03ae \u03b1\u03c4\u03c1\u03bf\u03c6\u03af\u03b1.<sup>77<\/sup> \u0397 \u03b5\u03c0\u03af\u03c4\u03b5\u03c5\u03be\u03b7 \u03b9\u03ba\u03b1\u03bd\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03c4\u03b9\u03c3\u03c5\u03bb\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b4\u03c1\u03ac\u03c3\u03b7\u03c2 \u03bc\u03b5 \u03c7\u03b1\u03bc\u03b7\u03bb\u03ad\u03c2 \u03b4\u03cc\u03c3\u03b5\u03b9\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03c0\u03bf\u03c6\u03c5\u03b3\u03ae \u03c4\u03c9\u03bd \u03c0\u03b1\u03c1\u03b5\u03bd\u03b5\u03c1\u03b3\u03b5\u03b9\u03ce\u03bd \u03b1\u03c5\u03c4\u03ce\u03bd \u03b4\u03b5\u03bd \u03ae\u03c4\u03b1\u03bd \u03b5\u03c6\u03b9\u03ba\u03c4\u03ae \u03bb\u03cc\u03b3\u03c9 \u03c4\u03b7\u03c2 \u03c7\u03b1\u03bc\u03b7\u03bb\u03ae\u03c2 \u03b2\u03b9\u03bf\u03b4\u03b9\u03b1\u03b8\u03b5\u03c3\u03b9\u03bc\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c4\u03b7\u03c2 adjudin. \u0388\u03c4\u03c3\u03b9, \u03b5\u03c0\u03b9\u03c7\u03b5\u03b9\u03c1\u03ae\u03b8\u03b7\u03ba\u03b5 \u03b7 \u03c3\u03c4\u03bf\u03c7\u03b5\u03c5\u03bc\u03ad\u03bd\u03b7 \u03b4\u03c1\u03ac\u03c3\u03b7 \u03c4\u03b7\u03c2 adjudin \u03c3\u03c4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 Sertoli, \u03bc\u03ad\u03c3\u03c9 \u03c4\u03b7\u03c2 \u03c0\u03c1\u03cc\u03c3\u03b4\u03b5\u03c3\u03ae\u03c2 \u03c4\u03b7\u03c2 \u03c3\u03b5 \u03c4\u03c1\u03bf\u03c0\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b7 FSH. \u03a7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03c3\u03b5 \u03b1\u03c1\u03bf\u03c5\u03c1\u03b1\u03af\u03bf\u03c5\u03c2 \u03c4\u03bf\u03c5 \u03c3\u03ba\u03b5\u03c5\u03ac\u03c3\u03bc\u03b1\u03c4\u03bf\u03c2 \u03bc\u03b5 \u03b5\u03c6\u03ac\u03c0\u03b1\u03be \u03ad\u03bd\u03b5\u03c3\u03b7 \u03c0\u03c1\u03bf\u03ba\u03ac\u03bb\u03b5\u03c3\u03b5 \u03c3\u03c4\u03b5\u03b9\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1 4 \u03ad\u03c9\u03c2 6 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7\u03bd \u03ad\u03bd\u03b5\u03c3\u03b7, \u03b5\u03bd\u03ce \u03b7 \u03b3\u03bf\u03bd\u03b9\u03bc\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b5\u03c0\u03b1\u03bd\u03ae\u03bb\u03b8\u03b5 \u03bc\u03ad\u03c3\u03b1 \u03c3\u03b5 5 \u03bc\u03ae\u03bd\u03b5\u03c2 \u03bc\u03b5 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03bf\u03cd\u03c2 \u03b1\u03c0\u03bf\u03b3\u03cc\u03bd\u03bf\u03c5\u03c2.<sup>77<\/sup><\/p>\n<p style=\"text-align: justify;\"><b>\u0399\u03bd\u03b4\u03b5\u03bd\u03bf\u03c0\u03c5\u03c1\u03b9\u03b4\u03af\u03bd\u03b5\u03c2. <\/b>\u039f\u03b9 \u03b9\u03bd\u03b4\u03b5\u03bd\u03bf\u03c0\u03c5\u03c1\u03b9\u03b4\u03af\u03bd\u03b5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03ad\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03bd\u03b5\u03cc\u03c4\u03b5\u03c1\u03b1 \u03b1\u03bd\u03c4\u03b9\u03b9\u03c3\u03c4\u03b1\u03bc\u03b9\u03bd\u03b9\u03ba\u03ac \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 \u03ba\u03b1\u03b9 \u03bf\u03b9 \u03b1\u03bd\u03c4\u03b9\u03c3\u03c5\u03bb\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03b9\u03b4\u03b9\u03cc\u03c4\u03b7\u03c4\u03b5\u03c2 \u03b4\u03b9\u03b1\u03c0\u03b9\u03c3\u03c4\u03ce\u03b8\u03b7\u03ba\u03b1\u03bd \u03ba\u03b1\u03c4\u03ac \u03c4\u03bf\u03bd \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c4\u03c9\u03bd \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd \u03b1\u03c5\u03c4\u03ce\u03bd. \u0397 \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03ae \u03c4\u03bf\u03c5\u03c2 \u03c3\u03c4\u03b7 \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7 \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03b1\u03c6\u03bf\u03c1\u03ac \u03c4\u03cc\u03c3\u03bf \u03c4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 Sertoli \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03b3\u03b5\u03bd\u03bd\u03b7\u03c4\u03b9\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1.<sup>78<\/sup> \u03a0\u03b5\u03b9\u03c1\u03b1\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b9\u03bd\u03b4\u03b5\u03bd\u03bf\u03c0\u03c5\u03c1\u03b9\u03b4\u03af\u03bd\u03b7\u03c2 CDB &#8211; 4022, \u03c4\u03cc\u03c3\u03bf \u03c3\u03b5 \u03b1\u03c1\u03bf\u03c5\u03c1\u03b1\u03af\u03bf\u03c5\u03c2 \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03c0\u03b9\u03b8\u03ae\u03ba\u03bf\u03c5\u03c2 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af \u03c3\u03bf\u03b2\u03b1\u03c1\u03ae \u03bf\u03bb\u03b9\u03b3\u03bf\u03b6\u03c9\u03bf\u03c3\u03c0\u03b5\u03c1\u03bc\u03af\u03b1, \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03c1\u03ad\u03c8\u03b9\u03bc\u03b7, \u03c7\u03c9\u03c1\u03af\u03c2 \u03b5\u03bc\u03c6\u03b1\u03bd\u03ae \u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1.<sup>79<\/sup> \u039f \u03b1\u03ba\u03c1\u03b9\u03b2\u03ae\u03c2 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2 \u03c4\u03b7\u03c2 \u03b4\u03c1\u03ac\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c3\u03b1\u03c6\u03ae\u03c2.<b><\/b><\/p>\n<p style=\"text-align: justify;\"><b>\u0391\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c1\u03b5\u03c4\u03b9\u03bd\u03bf\u03ca\u03ba\u03bf\u03cd \u03bf\u03be\u03ad\u03bf\u03c2 \u03cc\u03c1\u03c7\u03b5\u03c9\u03bd. <\/b>\u0389\u03c4\u03b1\u03bd \u03ae\u03b4\u03b7 \u03b3\u03bd\u03c9\u03c3\u03c4\u03cc \u03b1\u03c0\u03cc \u03c4\u03b7 \u03b4\u03b5\u03ba\u03b1\u03b5\u03c4\u03af\u03b1 \u03c4\u03bf\u03c5 1920 \u03cc\u03c4\u03b9 \u03b7 \u03b2\u03b9\u03c4\u03b1\u03bc\u03af\u03bd\u03b7 \u0391 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03b1\u03c1\u03b1\u03af\u03c4\u03b7\u03c4\u03b7 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03c3\u03c0\u03ad\u03c1\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03ac\u03bd\u03b4\u03c1\u03b5\u03c2.<sup>80<\/sup> \u039c\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c3\u03b5 \u03c0\u03bf\u03bd\u03c4\u03af\u03ba\u03b9\u03b1 \u03ad\u03b4\u03b5\u03b9\u03be\u03b1\u03bd \u03cc\u03c4\u03b9 \u03bf \u03b5\u03bd\u03b5\u03c1\u03b3\u03cc\u03c2 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03af\u03c4\u03b7\u03c2 \u03c4\u03b7\u03c2, \u03c1\u03b5\u03c4\u03b9\u03bd\u03bf\u03ca\u03ba\u03cc \u03bf\u03be\u03cd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03b1\u03c1\u03b1\u03af\u03c4\u03b7\u03c4\u03bf\u03c2 \u03c3\u03b5 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b5\u03c2 \u03c0\u03bf\u03c3\u03cc\u03c4\u03b7\u03c4\u03b5\u03c2 \u03c3\u03c4\u03bf \u03b5\u03c3\u03c9\u03c4\u03b5\u03c1\u03b9\u03ba\u03cc \u03c4\u03c9\u03bd \u03cc\u03c1\u03c7\u03b5\u03c9\u03bd \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03ba\u03b1\u03bd\u03bf\u03bd\u03b9\u03ba\u03ae \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03c3\u03c0\u03ad\u03c1\u03bc\u03b1\u03c4\u03bf\u03c2.<sup>81<\/sup> \u0391\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03b7\u03c2 \u03bc\u03b5\u03c4\u03b1\u03c4\u03c1\u03bf\u03c0\u03ae\u03c2 \u03c4\u03b7\u03c2 \u03b2\u03b9\u03c4\u03b1\u03bc\u03af\u03bd\u03b7\u03c2 \u0391 \u03c3\u03b5 \u03c1\u03b5\u03c4\u03b9\u03bd\u03bf\u03ca\u03ba\u03cc \u03bf\u03be\u03cd \u03ae \u03c4\u03c9\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03c9\u03bd \u03c4\u03bf\u03c5 \u03c1\u03b5\u03c4\u03b9\u03bd\u03bf\u03ca\u03ba\u03bf\u03cd \u03bf\u03be\u03ad\u03bf\u03c2 \u03c3\u03c4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 Sertoli \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03b5 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ae \u03c4\u03b7\u03c2 \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7\u03c2.<b><\/b><\/p>\n<p style=\"text-align: justify;\">\u0397 \u03c7\u03c1\u03ae\u03c3\u03b7 \u03b4\u03b9\u03c3-\u03b4\u03b9\u03c7\u03bb\u03c9\u03c1\u03bf-\u03b1\u03ba\u03b5\u03c4\u03c5\u03bb-\u03b4\u03b9\u03b1\u03bc\u03af\u03bd\u03b7\u03c2 (WIN 18446) \u03ae\u03c4\u03b1\u03bd \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03c0\u03c1\u03ce\u03c4\u03b5\u03c2 \u03c0\u03c1\u03bf\u03c3\u03c0\u03ac\u03b8\u03b5\u03b9\u03b5\u03c2 \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03c4\u03b9\u03c3\u03cd\u03bb\u03bb\u03b7\u03c8\u03b7\u03c2 \u03c3\u03c4\u03bf\u03bd \u03ac\u03bd\u03b4\u03c1\u03b1 \u03c3\u03c4\u03b9\u03c2 \u0397\u03a0\u0391, \u03ae\u03b4\u03b7 \u03b1\u03c0\u03cc \u03c4\u03bf 1960. \u0391\u03c0\u03cc \u03c4\u03bf\u03c5 \u03c3\u03c4\u03cc\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03ae \u03c4\u03b7\u03c2 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03bf\u03cd\u03c3\u03b5 \u03b5\u03bb\u03ac\u03c4\u03c4\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c3\u03c5\u03b3\u03ba\u03b5\u03bd\u03c4\u03c1\u03ce\u03c3\u03b5\u03c9\u03bd \u03c4\u03c9\u03bd \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b6\u03c9\u03b1\u03c1\u03af\u03c9\u03bd \u03c3\u03b5 \u03b1\u03c3\u03c6\u03b1\u03bb\u03ae \u03cc\u03c1\u03b9\u03b1 (&lt;1 \u03b5\u03ba\u03b1\u03c4\u03bf\u03bc\u03bc\u03cd\u03c1\u03b9\u03bf\/ml), \u03bc\u03b5 \u03c0\u03bb\u03ae\u03c1\u03b7 \u03b1\u03bd\u03c4\u03b9\u03c3\u03c4\u03c1\u03b5\u03c8\u03b9\u03bc\u03cc\u03c4\u03b7\u03c4\u03b1.<sup>82<\/sup> \u0392\u03b9\u03bf\u03c8\u03af\u03b5\u03c2 \u03cc\u03c1\u03c7\u03b5\u03c9\u03bd \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7\u03bd \u03b1\u03b3\u03c9\u03b3\u03ae \u03ad\u03b4\u03b5\u03b9\u03c7\u03bd\u03b1\u03bd \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03b7\u03c2 \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7\u03c2 \u03c3\u03c4\u03bf \u03c3\u03c4\u03ac\u03b4\u03b9\u03bf \u03c4\u03c9\u03bd \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b3\u03bf\u03bd\u03af\u03c9\u03bd. \u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03b4\u03b5\u03bd \u03c5\u03c0\u03ae\u03c1\u03be\u03b5 \u03c3\u03c5\u03bd\u03ad\u03c7\u03b5\u03b9\u03b1 \u03c3\u03c4\u03b7\u03bd \u03c0\u03c1\u03bf\u03c3\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1 \u03b1\u03c5\u03c4\u03ae, \u03ba\u03b1\u03b8\u03ce\u03c2 \u03c3\u03c5\u03b3\u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03b1\u03bb\u03ba\u03bf\u03cc\u03bb \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03bf\u03cd\u03c3\u03b5 \u03ad\u03bd\u03c4\u03bf\u03bd\u03b7 \u00ab\u03b1\u03bd\u03c4\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03b4\u03b9\u03c3\u03bf\u03c5\u03bb\u03c6\u03b9\u03c1\u03ac\u03bc\u03b7\u03c2\u00bb \u03bc\u03b5 \u03b5\u03be\u03ac\u03c8\u03b5\u03b9\u03c2, \u03bd\u03b1\u03c5\u03c4\u03af\u03b1 \u03ba\u03b1\u03b9 \u03b1\u03af\u03c3\u03b8\u03b7\u03bc\u03b1 \u03c0\u03b1\u03bb\u03bc\u03ce\u03bd. \u0391\u03c1\u03ba\u03b5\u03c4\u03ac \u03b1\u03c1\u03b3\u03cc\u03c4\u03b5\u03c1\u03b1 \u03ba\u03b1\u03c4\u03b1\u03bd\u03bf\u03ae\u03b8\u03b7\u03ba\u03b5 \u03bf \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2 \u03b4\u03c1\u03ac\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 WIN 18446, \u03c4\u03bf \u03bf\u03c0\u03bf\u03af\u03bf \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03b5\u03b9 \u03c4\u03b7 \u03bc\u03b5\u03c4\u03b1\u03c4\u03c1\u03bf\u03c0\u03ae \u03c4\u03b7\u03c2 \u03b2\u03b9\u03c4\u03b1\u03bc\u03af\u03bd\u03b7\u03c2 \u0391 \u03c3\u03b5 \u03c1\u03b5\u03c4\u03b9\u03bd\u03bf\u03ca\u03ba\u03cc \u03bf\u03be\u03cd.<sup>83<\/sup><\/p>\n<p style=\"text-align: justify;\">\u039f \u03b1\u03bd\u03c4\u03b1\u03b3\u03c9\u03bd\u03b9\u03c3\u03c4\u03ae\u03c2 \u03c4\u03bf\u03c5 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03c4\u03bf\u03c5 \u03c1\u03b5\u03c4\u03b9\u03bd\u03bf\u03ca\u03ba\u03bf\u03cd 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\u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03b7\u03c2 \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03bf\u03cd\u03c3\u03b1\u03c2 \u03c4\u03b5\u03c3\u03c4\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7\u03c2. \u0391\u03bd\u03ac\u03ba\u03b1\u03bc\u03c8\u03b7 \u03c4\u03b7\u03c2 \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae\u03c2 \u03c3\u03c0\u03ad\u03c1\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c3\u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c0\u03c1\u03bf \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03ae\u03b8\u03b7\u03ba\u03b5 \u03c3\u03b5 \u03cc\u03bb\u03b5\u03c2 \u03c4\u03b9\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03ba\u03b1\u03b9 \u03bf \u03c7\u03c1\u03cc\u03bd\u03bf\u03c2 \u03b1\u03c0\u03bf\u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7\u03c2 \u03ae\u03c4\u03b1\u03bd \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03bf\u03c2 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03ad\u03bd\u03c4\u03b1\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c5\u03c0\u03b5\u03c1\u03ae\u03c7\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c4\u03b7 \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03c4\u03c9\u03bd \u03c3\u03c5\u03bd\u03b5\u03b4\u03c1\u03b9\u03ce\u03bd.<sup>93<\/sup><\/p>\n<h5 style=\"text-align: justify;\">4.2. \u0394\u03b9\u03b1\u03c4\u03ac\u03c1\u03b1\u03be\u03b7 \u03c4\u03b7\u03c2 \u03bc\u03b5\u03c4\u03b1\u03c6\u03bf\u03c1\u03ac\u03c2 \u03ba\u03b1\u03b9 \u03c9\u03c1\u03af\u03bc\u03b1\u03bd\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b6\u03c9\u03b1\u03c1\u03af\u03c9\u03bd \u03b5\u03bd\u03c4\u03cc\u03c2 \u03c4\u03b7\u03c2 \u03b5\u03c0\u03b9\u03b4\u03b9\u03b4\u03c5\u03bc\u03af\u03b4\u03b1\u03c2<\/h5>\n<h6 style=\"text-align: justify;\">4.2.1. \u03a6\u03c5\u03c3\u03b9\u03ba\u03ad\u03c2 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf\u03b9<\/h6>\n<p style=\"text-align: justify;\">\u039f\u03b9 \u03b1\u03bd\u03c4\u03b9\u03c3\u03c5\u03bb\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf\u03b9 \u03bf\u03b9 \u03bf\u03c0\u03bf\u03af\u03b5\u03c2 \u03b1\u03c0\u03b5\u03c5\u03b8\u03cd\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03bf \u03c4\u03b7\u03c2 \u03b5\u03c0\u03b9\u03b4\u03b9\u03b4\u03c5\u03bc\u03af\u03b4\u03b1\u03c2 \u03c3\u03c4\u03bf\u03c7\u03b5\u03cd\u03bf\u03c5\u03bd \u03c4\u03b1 \u03ae\u03b4\u03b7 \u03c3\u03c7\u03b7\u03bc\u03b1\u03c4\u03b9\u03c3\u03bc\u03ad\u03bd\u03b1 \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b6\u03c9\u03ac\u03c1\u03b9\u03b1, \u03bc\u03b5 \u03c3\u03ba\u03bf\u03c0\u03cc \u03b5\u03af\u03c4\u03b5 \u03bd\u03b1 \u03b5\u03bc\u03c0\u03bf\u03b4\u03af\u03c3\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03c0\u03b5\u03c1\u03b1\u03b9\u03c4\u03ad\u03c1\u03c9 \u03bc\u03b5\u03c4\u03b1\u03c6\u03bf\u03c1\u03ac \u03c4\u03bf\u03c5\u03c2 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\u03bc\u03b5\u03c4\u03b1\u03c6\u03bf\u03c1\u03ac\u03c2 \u03c4\u03c9\u03bd \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b6\u03c9\u03b1\u03c1\u03af\u03c9\u03bd. <\/b>\u0391\u03c0\u03cc \u03c4\u03b7 \u03b4\u03b5\u03ba\u03b1\u03b5\u03c4\u03af\u03b1 \u03c4\u03bf\u03c5 1970 \u03b5\u03af\u03c7\u03b5 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b7\u03b8\u03b5\u03af \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ae \u03c4\u03b7\u03c2 \u03b5\u03ba\u03c3\u03c0\u03b5\u03c1\u03bc\u03ac\u03c4\u03b9\u03c3\u03b7\u03c2 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bf\u03b9 \u03bf\u03c0\u03bf\u03af\u03bf\u03b9 \u03b5\u03bb\u03ac\u03bc\u03b2\u03b1\u03bd\u03b1\u03bd \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03c4\u03bf\u03c5 \u03b1-\u03b1\u03b4\u03c1\u03b5\u03bd\u03b5\u03c1\u03b3\u03b9\u03ba\u03bf\u03cd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 (\u03c0.\u03c7., 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\u03bf\u03c0\u03bf\u03af\u03bf\u03c2 \u03b5\u03ba\u03ba\u03c1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03ad\u03c3\u03b1 \u03c3\u03c4\u03bf\u03bd \u03b1\u03c5\u03bb\u03cc \u03ba\u03b1\u03b9 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7 \u03b3\u03bf\u03bd\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03ae \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b6\u03c9\u03b1\u03c1\u03af\u03c9\u03bd \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7 \u03bc\u03b5\u03c4\u03b1\u03c6\u03bf\u03c1\u03ac \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b1\u03c0\u03bf\u03b8\u03ae\u03ba\u03b5\u03c5\u03c3\u03b7 \u03c3\u03c0\u03ad\u03c1\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03b4\u03b9\u03b4\u03c5\u03bc\u03af\u03b4\u03b1.<sup>105<\/sup><\/p>\n<p style=\"text-align: justify;\">\u039c\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ae 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\u03b1\u03c0\u03bf\u03b8\u03b7\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03c9\u03bd<\/b> <b>\u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b6\u03c9\u03b1\u03c1\u03af\u03c9\u03bd. <\/b>\u0397 \u03c0\u03c1\u03bf\u03c3\u03b2\u03bf\u03bb\u03ae \u03c4\u03c9\u03bd \u03b5\u03bd\u03c4\u03cc\u03c2 \u03c4\u03b7\u03c2 \u03b5\u03c0\u03b9\u03b4\u03b9\u03b4\u03c5\u03bc\u03af\u03b4\u03b1\u03c2 \u03b1\u03c0\u03bf\u03b8\u03b7\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03c9\u03bd \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b6\u03c9\u03b1\u03c1\u03af\u03c9\u03bd \u03b8\u03b1 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03c3\u03b5 \u03bd\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03b5\u03b9 \u03b8\u03b5\u03c9\u03c1\u03b7\u03c4\u03b9\u03ba\u03ac \u03c4\u03b7\u03bd \u03c0\u03b9\u03bf \u03c4\u03b1\u03c7\u03b5\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03bf\u03c7\u03b5\u03c5\u03bc\u03ad\u03bd\u03b7 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf \u03b1\u03bd\u03c4\u03b9\u03c3\u03cd\u03bb\u03bb\u03b7\u03c8\u03b7\u03c2. \u03a0\u03c1\u03bf\u03cb\u03c0\u03cc\u03b8\u03b5\u03c3\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf\u03b9 \u03b5\u03bc\u03c0\u03bb\u03b5\u03ba\u03cc\u03bc\u03b5\u03bd\u03b5\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2 \u03bd\u03b1 \u03ba\u03b1\u03c4\u03b5\u03c5\u03b8\u03cd\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b5\u03ba\u03bb\u03b5\u03ba\u03c4\u03b9\u03ba\u03ac \u03b5\u03bd\u03b1\u03bd\u03c4\u03af\u03bf\u03bd \u03bc\u03bf\u03c1\u03af\u03c9\u03bd \u03c3\u03c4\u03cc\u03c7\u03c9\u03bd \u03b5\u03c0\u03af \u03c4\u03c9\u03bd \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b6\u03c9\u03b1\u03c1\u03af\u03c9\u03bd \u03c0\u03bf\u03c5 \u03b4\u03b5\u03bd \u03b1\u03c0\u03b1\u03bd\u03c4\u03ce\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03ac\u03bb\u03bb\u03bf\u03c5\u03c2 \u03b9\u03c3\u03c4\u03bf\u03cd\u03c2 \u03ba\u03b1\u03b9 \u03b5\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd \u03bd\u03b1 \u03bc\u03b7 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\u03b1\u03c0\u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b6\u03c9\u03b1\u03c1\u03af\u03c9\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03bc\u03b7 \u03b1\u03bd\u03b1\u03c3\u03c4\u03c1\u03ad\u03c8\u03b9\u03bc\u03b7 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03bf\u03c5 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03c3\u03bc\u03bf\u03cd \u03c4\u03bf\u03c5\u03c2, \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c0\u03b1\u03c1\u03b1\u03b2\u03bb\u03ac\u03c0\u03c4\u03b5\u03b9 \u03b5\u03c5\u03b8\u03ad\u03c9\u03c2 \u03c4\u03b7\u03bd \u03ba\u03b9\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03ac \u03c4\u03bf\u03c5\u03c2. \u0388\u03bd\u03b1\u03c2 \u03c4\u03ad\u03c4\u03bf\u03b9\u03bf\u03c2 \u03c3\u03c4\u03cc\u03c7\u03bf\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03b3\u03bb\u03c5\u03ba\u03cc\u03bb\u03c5\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b7 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03c9\u03bd \u03c4\u03c9\u03bd \u03b5\u03bd\u03b6\u03cd\u03bc\u03c9\u03bd \u03c0\u03bf\u03c5 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03ad\u03c7\u03bf\u03c5\u03bd \u03c3\u03b5 \u03b1\u03c5\u03c4\u03ae\u03bd [S-\u03b1\u03c6\u03c5\u03b4\u03c1\u03bf\u03b3\u03bf\u03bd\u03ac\u03c3\u03b7 \u03c4\u03b7\u03c2 3 &#8211; \u03c6\u03c9\u03c3\u03c6\u03bf\u03c1\u03b9\u03ba\u03ae\u03c2 \u03b3\u03bb\u03c5\u03ba\u03b5\u03c1\u03b1\u03bb\u03b4\u03b5\u03b0\u03b4\u03b7\u03c2 (GAPDS), \u03b9\u03c3\u03bf\u03bc\u03b5\u03c1\u03ac\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c6\u03c9\u03c3\u03c6\u03bf\u03c1\u03b9\u03ba\u03ae\u03c2 \u03c4\u03c1\u03b9\u03cc\u03b6\u03b7\u03c2 (\u03a4\u03a1\u0399)], \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03b7\u03bd \u03c0\u03c1\u03cc\u03ba\u03bb\u03b7\u03c3\u03b7 \u00ab\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03ae\u03c2\u00bb \u03c3\u03c4\u03b5\u03b9\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2.<sup>109<\/sup> \u03a3\u03c4\u03b7\u03bd \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b1 \u03c4\u03c9\u03bd \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03c9\u03bd \u03b1\u03c5\u03c4\u03ce\u03bd \u03b1\u03bd\u03ae\u03ba\u03b5\u03b9 \u03b7 \u03b1- \u03c7\u03bb\u03c9\u03c1\u03c5\u03b4\u03c1\u03af\u03bd\u03b7, \u03c4\u03b7\u03c2 \u03bf\u03c0\u03bf\u03af\u03b1\u03c2 \u03b7 \u03b4\u03c1\u03ac\u03c3\u03b7 \u03cc\u03bc\u03c9\u03c2 \u03b4\u03b5\u03bd \u03c0\u03b5\u03c1\u03b9\u03bf\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b1 \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b6\u03c9\u03ac\u03c1\u03b9\u03b1 \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03b7\u03bd \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7 \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2 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\u03c4\u03bf\u03c5\u03c2, \u03c7\u03c9\u03c1\u03af\u03c2 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ae \u03c4\u03b7\u03c2 \u03c3\u03cd\u03c3\u03c4\u03b1\u03c3\u03b7\u03c2 \u03c4\u03bf \u03c5\u03b3\u03c1\u03bf\u03cd \u03c4\u03b7\u03c2 \u03b5\u03c0\u03b9\u03b4\u03b9\u03b4\u03c5\u03bc\u03af\u03b4\u03b1\u03c2. \u039f \u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03b9\u03c3\u03bc\u03cc\u03c2 \u03c4\u03c9\u03bd \u03b4\u03b9\u03b1\u03cd\u03bb\u03c9\u03bd K<sup>+<\/sup>, Cl<sup> \u2013<\/sup> \u03bc\u03b5 \u03ba\u03b9\u03bd\u03af\u03bd\u03b7 \u03ae \u03bf\u03c1\u03bd\u03b9\u03b4\u03b1\u03b6\u03cc\u03bb\u03b7 \u03ad\u03c7\u03b5\u03b9 \u03c9\u03c2 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03b7\u03bd \u03b5\u03be\u03bf\u03af\u03b4\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b6\u03c9\u03b1\u03c1\u03af\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b1\u03b4\u03c5\u03bd\u03b1\u03bc\u03af\u03b1 \u03c0\u03c1\u03bf\u03ce\u03b8\u03b7\u03c3\u03ae\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03b5\u03bd\u03c4\u03cc\u03c2 \u03c4\u03b7\u03c2 \u03b2\u03bb\u03ad\u03bd\u03bd\u03b7\u03c2 \u03c3\u03c4\u03bf \u03b3\u03c5\u03bd\u03b1\u03b9\u03ba\u03b5\u03af\u03bf \u03b3\u03b5\u03bd\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc \u03c3\u03cd\u03c3\u03c4\u03b7\u03bc\u03b1. \u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03b7 \u03b1\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1 \u03b1\u03c5\u03c4\u03ce\u03bd \u03c4\u03c9\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03cc\u03bd\u03c4\u03c9\u03bd \u03b4\u03b5\u03bd \u03ad\u03c7\u03b5\u03b9 \u03c4\u03b5\u03ba\u03bc\u03b7\u03c1\u03b9\u03c9\u03b8\u03b5\u03af \u03b1\u03c6\u03bf\u03cd \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03b5\u03ba\u03bb\u03b5\u03ba\u03c4\u03b9\u03ba\u03bf\u03af.<sup>110<\/sup><\/p>\n<p style=\"text-align: justify;\">\u0386\u03bb\u03bb\u03bf\u03c2 \u03c4\u03c1\u03cc\u03c0\u03bf\u03c2 \u03b1\u03b4\u03c1\u03b1\u03bd\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b6\u03c9\u03b1\u03c1\u03af\u03c9\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03b7\u03c2 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7\u03c2 (capacitation) \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c3\u03c5\u03bc\u03b2\u03b1\u03af\u03bd\u03b5\u03b9 \u03b5\u03bd\u03c4\u03cc\u03c2 \u03c4\u03b7\u03c2 \u03b5\u03c0\u03b9\u03b4\u03b9\u03b4\u03c5\u03bc\u03af\u03b4\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03bf \u03c0\u03b5\u03c1\u03b9\u03bf\u03c1\u03b9\u03c3\u03bc\u03cc\u03c2 \u03c4\u03b7\u03c2 \u03ba\u03b9\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03ac\u03c2 \u03c4\u03bf\u03c5\u03c2. \u03a0\u03c1\u03cc\u03c3\u03c6\u03b1\u03c4\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b5\u03c0\u03b9\u03ba\u03b5\u03bd\u03c4\u03c1\u03c9\u03b8\u03b5\u03af \u03c3\u03b5 \u03bc\u03af\u03b1 \u03bd\u03ad\u03b1 \u03bf\u03bc\u03ac\u03b4\u03b1 \u03b4\u03b9\u03b1\u03cd\u03bb\u03c9\u03bd \u03b1\u03c3\u03b2\u03b5\u03c3\u03c4\u03af\u03bf\u03c5, \u03bf\u03b9 \u03bf\u03c0\u03bf\u03af\u03bf\u03b9 \u03bf\u03bd\u03bf\u03bc\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 &#8220;CatSpers&#8221;.<sup>111<\/sup> \u03a0\u03c1\u03cc\u03ba\u03b5\u03b9\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03b1\u03c3\u03b5\u03bf-\u03b5\u03c5\u03b1\u03af\u03c3\u03b8\u03b7\u03c4\u03bf\u03c5\u03c2 \u03b4\u03b9\u03b1\u03cd\u03bb\u03bf\u03c5\u03c2, \u03bf \u03c1\u03cc\u03bb\u03bf\u03c2 \u03c4\u03c9\u03bd \u03bf\u03c0\u03bf\u03af\u03c9\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03bd\u03b1 \u03b5\u03c0\u03b9\u03c4\u03c1\u03ad\u03c0\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03b5\u03af\u03c3\u03bf\u03b4\u03bf \u03c4\u03bf\u03c5 \u03b1\u03c3\u03b2\u03b5\u03c3\u03c4\u03af\u03bf\u03c5 \u03bc\u03ad\u03c3\u03b1 \u03c3\u03c4\u03b1 \u03bd\u03b5\u03b1\u03c1\u03ac \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b6\u03c9\u03ac\u03c1\u03b9\u03b1, \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03b7\u03bd \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03bf\u03c0\u03bf\u03af\u03b1 \u03c0\u03ac\u03bb\u03bb\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03bf\u03c5\u03c1\u03ac \u03c4\u03bf\u03c5\u03c2. \u0388\u03bb\u03bb\u03b5\u03b9\u03c8\u03b7 \u03ad\u03c3\u03c4\u03c9 \u03ba\u03b1\u03b9 \u03bc\u03af\u03b1\u03c2 \u03b5\u03ba \u03c4\u03c9\u03bd CatSpers \u03c3\u03c5\u03bd\u03b5\u03c0\u03ac\u03b3\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b5\u03b9\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1, \u03c9\u03c3\u03c4\u03cc\u03c3\u03bf \u03bf\u03b9 \u03b5\u03c5\u03c1\u03ad\u03c9\u03c2 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bc\u03b5\u03bd\u03bf\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03ce\u03c0\u03b9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7\u03c2 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03b4\u03b9\u03b1\u03cd\u03bb\u03c9\u03bd \u03b1\u03c3\u03b2\u03b5\u03c3\u03c4\u03af\u03bf\u03c5 \u03b4\u03b5 \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03ba\u03ac\u03c0\u03bf\u03b9\u03b1 \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c3\u03c4\u03b7 \u03b3\u03bf\u03bd\u03b9\u03bc\u03cc\u03c4\u03b7\u03c4\u03b1, \u03b5\u03bd\u03ce \u03c9\u03c2 \u03c4\u03ce\u03c1\u03b1 \u03b4\u03b5\u03bd \u03ad\u03c7\u03bf\u03c5\u03bd \u03b1\u03bd\u03b1\u03c0\u03c4\u03c5\u03c7\u03b8\u03b5\u03af \u03b5\u03ba\u03bb\u03b5\u03ba\u03c4\u03b9\u03ba\u03bf\u03af \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03c4\u03b7\u03c2 \u03b4\u03c1\u03ac\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd CatSpers.<sup>112<\/sup> \u0388\u03bd\u03b1\u03c2 \u03b5\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd \u03c3\u03c4\u03cc\u03c7\u03bf\u03c2 \u03b3\u03b9\u03b1 \u03b1\u03bd\u03b4\u03c1\u03b9\u03ba\u03ae \u03b1\u03bd\u03c4\u03b9\u03c3\u03cd\u03bb\u03bb\u03b7\u03c8\u03b7 \u03b8\u03b1 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03c3\u03b5 \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03b4\u03b9\u03b1\u03bb\u03c5\u03c4\u03ae \u03bc\u03bf\u03c1\u03c6\u03ae \u03c4\u03b7\u03c2 \u03b1\u03b4\u03b5\u03bd\u03c5\u03bb\u03b9\u03ba\u03ae\u03c2 \u03ba\u03c5\u03ba\u03bb\u03ac\u03c3\u03b7\u03c2 (sAC), \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03bf\u03c5 \u03b5\u03bd\u03b4\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03b9\u03bf\u03c5 cAMP, \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03b1\u03c0\u03b1\u03c1\u03b1\u03af\u03c4\u03b7\u03c4\u03bf\u03c5 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03ba\u03b9\u03bd\u03b7\u03c4\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b6\u03c9\u03b1\u03c1\u03af\u03c9\u03bd. \u03a0\u03bf\u03bd\u03c4\u03af\u03ba\u03b9\u03b1 \u03bc\u03b5 \u03ad\u03bb\u03bb\u03b5\u03b9\u03c8\u03b7 \u03c4\u03b7\u03c2 sAC \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c4\u03b5\u03af\u03c1\u03b1, \u03bb\u03cc\u03b3\u03c9 \u03b5\u03bb\u03b1\u03c4\u03c4\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae\u03c2 cAMP, \u03c9\u03c3\u03c4\u03cc\u03c3\u03bf \u03bf\u03cd\u03c4\u03b5 \u03b5\u03bd\u03b1\u03bd\u03c4\u03af\u03bf\u03bd \u03b1\u03c5\u03c4\u03ae\u03c2 \u03c4\u03b7\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b1\u03bd\u03b1\u03c0\u03c4\u03c5\u03c7\u03b8\u03b5\u03af \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2.<sup>113<\/sup><\/p>\n<p style=\"text-align: justify;\">\u03a4\u03ad\u03bb\u03bf\u03c2, \u03bc\u03af\u03b1 \u03b1\u03be\u03b9\u03bf\u03c3\u03b7\u03bc\u03b5\u03af\u03c9\u03c4\u03b7 \u03c0\u03c1\u03bf\u03c3\u03ad\u03b3\u03b3\u03b9\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b5\u03c0\u03af\u03c4\u03b5\u03c5\u03be\u03b7 \u03b1\u03bd\u03b4\u03c1\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03c4\u03b9\u03c3\u03cd\u03bb\u03bb\u03b7\u03c8\u03b7\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03c0\u03b1\u03c1\u03ad\u03bc\u03b2\u03b1\u03c3\u03b7 \u03c3\u03c4\u03bf\u03bd \u03c4\u03c1\u03cc\u03c0\u03bf \u03bc\u03b5 \u03c4\u03bf\u03bd \u03bf\u03c0\u03bf\u03af\u03bf \u03c4\u03b1 \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b6\u03c9\u03ac\u03c1\u03b9\u03b1 \u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03b9\u03b4\u03c1\u03bf\u03cd\u03bd \u03bc\u03b5 \u03c4\u03bf \u03c9\u03ac\u03c1\u03b9\u03bf. \u03a4\u03b1 \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b6\u03c9\u03ac\u03c1\u03b9\u03b1 \u03c0\u03b5\u03c1\u03b9\u03ad\u03c7\u03bf\u03c5\u03bd \u03c4\u03bf \u03ad\u03bd\u03b6\u03c5\u03bc\u03bf \u039d-\u03b1\u03ba\u03b5\u03c4\u03c5\u03bb\u03bf-\u03b2-D- \u03b5\u03be\u03bf\u03b6\u03b1\u03bc\u03b9\u03bd\u03b9\u03b4\u03ac\u03c3\u03b7 \u03c4\u03cd\u03c0\u03bf\u03c5 \u0392 \u03ae HEX \u2013 \u0392, \u03c4\u03bf \u03bf\u03c0\u03bf\u03af\u03bf \u03b4\u03b9\u03b1\u03c3\u03c0\u03ac \u03c4\u03b9\u03c2 \u03b3\u03bb\u03c5\u03ba\u03bf\u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2 \u0396\u03a1 \u03c4\u03b7\u03c2 \u03b4\u03b9\u03b1\u03c6\u03b1\u03bd\u03bf\u03cd\u03c2 \u03b6\u03ce\u03bd\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03c9\u03b1\u03c1\u03af\u03bf\u03c5. \u039c\u03c0\u03bb\u03bf\u03ba\u03ac\u03c1\u03b9\u03c3\u03bc\u03b1 \u03b5\u03c0\u03bf\u03bc\u03ad\u03bd\u03c9\u03c2 \u03c4\u03bf\u03c5 \u03b5\u03bd\u03b6\u03cd\u03bc\u03bf\u03c5 \u03b1\u03c5\u03c4\u03bf\u03cd \u03bc\u03b5 \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03c4\u03c9\u03bd \u03b3\u03bb\u03c5\u03ba\u03bf\u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03ce\u03bd \u0396\u03a1 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03ae \u03c3\u03c4\u03b5\u03b9\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c7\u03c9\u03c1\u03af\u03c2 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ae \u03c4\u03bf\u03c5 \u03b1\u03c1\u03b9\u03b8\u03bc\u03bf\u03cd \u03c4\u03c9\u03bd \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b6\u03c9\u03b1\u03c1\u03af\u03c9\u03bd.<sup>114<\/sup> \u00a0\u0394\u03bf\u03ba\u03b9\u03bc\u03ae in vitro \u03bf\u03c5\u03c3\u03b9\u03ce\u03bd \u03c0\u03bf\u03c5 \u03bc\u03c0\u03bb\u03bf\u03ba\u03ac\u03c1\u03bf\u03c5\u03bd \u03c4\u03bf \u03ad\u03bd\u03b6\u03c5\u03bc\u03bf \u03b1\u03c5\u03c4\u03cc \u03c3\u03b5 \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b6\u03c9\u03ac\u03c1\u03b9\u03b1 \u03b1\u03c1\u03bf\u03c5\u03c1\u03b1\u03af\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c4\u03b1\u03cd\u03c1\u03c9\u03bd \u03b5\u03af\u03c7\u03b5 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 98% \u03cc\u03c3\u03bf\u03bd \u03b1\u03c6\u03bf\u03c1\u03ac \u03c4\u03b7\u03bd \u03b1\u03b4\u03c5\u03bd\u03b1\u03bc\u03af\u03b1 \u03b3\u03bf\u03bd\u03b9\u03bc\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7\u03c2, \u03b5\u03bd\u03ce in vivo, \u03c4\u03b1 \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03bf\u03b9\u03c7\u03b1 \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03ac \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03ae\u03c4\u03b1\u03bd 90%, \u03c7\u03c9\u03c1\u03af\u03c2 \u03b5\u03bc\u03c6\u03b1\u03bd\u03b5\u03af\u03c2 \u03c0\u03b1\u03c1\u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b3\u03bf\u03bd\u03b9\u03bc\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c3\u03b5 1 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b1 \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7 \u03b4\u03b9\u03b1\u03ba\u03bf\u03c0\u03ae \u03c4\u03b7\u03c2 \u03b1\u03b3\u03c9\u03b3\u03ae\u03c2.<sup>115<\/sup><\/p>\n<p style=\"text-align: justify;\">\u0388\u03c7\u03b5\u03b9 \u03ae\u03b4\u03b7 \u03b1\u03bd\u03b1\u03c6\u03b5\u03c1\u03b8\u03b5\u03af \u03b7 \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c4\u03b7\u03bd \u03bf\u03c0\u03bf\u03af\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03b7 \u03b1\u03bd\u03af\u03c7\u03bd\u03b5\u03c5\u03c3\u03b7 \u03b8\u03b5\u03c4\u03b9\u03ba\u03ce\u03bd \u03b1\u03bd\u03c4\u03b9-\u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03b9\u03ba\u03ce\u03bd \u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03c3\u03c4\u03b7 \u03b3\u03bf\u03bd\u03b9\u03bc\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03c9\u03bd \u03b1\u03bd\u03b4\u03c1\u03ce\u03bd.<sup>116<\/sup> \u039a\u03b1\u03c4\u03ac \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03bf \u03c4\u03c1\u03cc\u03c0\u03bf \u03b8\u03b1 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03c3\u03b5 \u03b7 \u03b5\u03bd\u03b5\u03c1\u03b3\u03b7\u03c4\u03b9\u03ba\u03ae \u03b1\u03bd\u03bf\u03c3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03c4\u03c9\u03bd \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b6\u03c9\u03b1\u03c1\u03af\u03c9\u03bd \u03bd\u03b1 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03b5\u03af \u03c9\u03c2 \u03bc\u03af\u03b1 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf\u03c2 \u03b1\u03bd\u03b4\u03c1\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03c4\u03b9\u03c3\u03cd\u03bb\u03bb\u03b7\u03c8\u03b7\u03c2 \u03bc\u03b5 \u03b5\u03be\u03b1\u03b9\u03c1\u03b5\u03c4\u03b9\u03ba\u03ae \u03b5\u03b9\u03b4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1. \u0397 \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf\u03c2 \u03b1\u03bd\u03c4\u03b9\u03c3\u03cd\u03bb\u03bb\u03b7\u03c8\u03b7\u03c2 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03ae\u03b4\u03b7 \u03b5\u03c5\u03c1\u03ad\u03c9\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03c4\u03b7\u03c2 \u03ac\u03b3\u03c1\u03b9\u03b1\u03c2 \u03b6\u03c9\u03ae\u03c2 \u03c3\u03b5 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03bf \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03bf\u03cd,<sup>117<\/sup> \u03c9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03bf\u03b9 \u03b1\u03c0\u03c1\u03cc\u03b2\u03bb\u03b5\u03c0\u03c4\u03b5\u03c2 \u03bc\u03b5\u03bc\u03bf\u03bd\u03c9\u03bc\u03ad\u03bd\u03b5\u03c2 \u03b1\u03c0\u03b1\u03bd\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2 \u03c0\u03bf\u03c5 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b7\u03b8\u03b5\u03af, \u03ba\u03b1\u03b8\u03ce\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03bf \u03b3\u03b5\u03b3\u03bf\u03bd\u03cc\u03c2 \u03cc\u03c4\u03b9, \u03b7 \u03b1\u03bd\u03b1\u03c3\u03c4\u03c1\u03b5\u03c8\u03b9\u03bc\u03cc\u03c4\u03b7\u03c4\u03ac \u03c4\u03b7\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b8\u03b5\u03c9\u03c1\u03b7\u03c4\u03b9\u03ba\u03ac \u03b4\u03cd\u03c3\u03ba\u03bf\u03bb\u03b7 \u03b5\u03be\u03b1\u03b9\u03c4\u03af\u03b1\u03c2 \u03c4\u03b7\u03c2 \u03cd\u03c0\u03b1\u03c1\u03be\u03b7\u03c2 \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae\u03c2 \u03bc\u03bd\u03ae\u03bc\u03b7\u03c2, \u03b4\u03b5\u03bd \u03ad\u03c7\u03b5\u03b9 \u03b1\u03ba\u03cc\u03bc\u03b1 \u03b5\u03c6\u03b1\u03c1\u03bc\u03bf\u03b3\u03ae \u03c4\u03b7\u03c2 \u03c3\u03c4\u03bf\u03bd \u03ac\u03bd\u03b8\u03c1\u03c9\u03c0\u03bf.<sup>118<\/sup> \u03a0\u03b5\u03b9\u03c1\u03ac\u03bc\u03b1\u03c4\u03b1 \u03b1\u03bd\u03bf\u03c3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7\u03c2 \u03c3\u03b5 \u03c0\u03c1\u03c9\u03c4\u03b5\u03cd\u03bf\u03bd\u03c4\u03b1 \u03bc\u03b5 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03b1\u03bd\u03b1\u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03ad\u03bd\u03b7\u03c2 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03b9\u03bd\u03b7\u03c2 \u03b5\u03c0\u03c0\u03af\u03bd\u03b7\u03c2 (\u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 \u03c4\u03b7\u03c2 \u03b5\u03c0\u03b9\u03b4\u03b9\u03b4\u03c5\u03bc\u03af\u03b4\u03b1\u03c2) \u03bf\u03b4\u03ae\u03b3\u03b7\u03c3\u03b5 \u03c3\u03b5 \u03b1\u03bd\u03b1\u03c3\u03c4\u03c1\u03ad\u03c8\u03b9\u03bc\u03b7 \u03b1\u03bd\u03c4\u03b9\u03c3\u03cd\u03bb\u03bb\u03b7\u03c8\u03b7 \u03c3\u03b5 \u03c0\u03ad\u03bd\u03c4\u03b5 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03b5\u03bd\u03bd\u03ad\u03b1 \u03b6\u03ce\u03b1, \u03c9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b4\u03b9\u03b1\u03c4\u03ae\u03c1\u03b7\u03c3\u03b7 \u03c5\u03c8\u03b7\u03bb\u03bf\u03cd \u03c4\u03af\u03c4\u03bb\u03bf\u03c5 \u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03b1\u03c0\u03b1\u03b9\u03c4\u03ae\u03b8\u03b7\u03ba\u03b1\u03bd \u03b1\u03bd\u03b1\u03bc\u03bd\u03b7\u03c3\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b4\u03cc\u03c3\u03b5\u03b9\u03c2 \u03b1\u03bd\u03ac 3 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03ba\u03b1\u03b8\u2019 \u03cc\u03bb\u03b7 \u03c4\u03b7 \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2.<sup>119<\/sup> \u0391\u03bd\u03c4\u03af\u03c3\u03c4\u03bf\u03b9\u03c7\u03b1 \u03b5\u03bc\u03b2\u03cc\u03bb\u03b9\u03b1 \u03bc\u03b5 \u03c3\u03c4\u03cc\u03c7\u03bf \u03c4\u03b9\u03c2 \u03b3\u03bf\u03bd\u03b1\u03b4\u03bf\u03c4\u03c1\u03bf\u03c0\u03af\u03bd\u03b5\u03c2 \u03ae \u03c4\u03b7 GnRH \u03ad\u03c7\u03bf\u03c5\u03bd \u03b4\u03bf\u03ba\u03b9\u03bc\u03b1\u03c3\u03c4\u03b5\u03af \u03c3\u03b5 \u03b3\u03c5\u03bd\u03b1\u03af\u03ba\u03b5\u03c2 (\u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c6\u03ac\u03c3\u03b7\u03c2 \u0399) \u03ba\u03b1\u03b9 \u03b8\u03b1 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03c3\u03b1\u03bd \u03ba\u03b1\u03c4\u2019 \u03b1\u03bd\u03b1\u03bb\u03bf\u03b3\u03af\u03b1 \u03bd\u03b1 \u03b5\u03c6\u03b1\u03c1\u03bc\u03bf\u03c3\u03b8\u03bf\u03cd\u03bd \u03c3\u03c4\u03bf\u03c5\u03c2 \u03ac\u03bd\u03b4\u03c1\u03b5\u03c2.<sup>120<\/sup><\/p>\n<h6 style=\"text-align: justify;\">4.2.1. \u039c\u03b7\u03c7\u03b1\u03bd\u03b9\u03ba\u03ad\u03c2 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf\u03b9<\/h6>\n<p style=\"text-align: justify;\">\u03a0\u03c1\u03cc\u03ba\u03b5\u03b9\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03bc\u03b5\u03b8\u03cc\u03b4\u03bf\u03c5\u03c2 \u03b5\u03bd\u03b1\u03bb\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c4\u03b7\u03c2 \u03b2\u03b1\u03b6\u03b5\u03ba\u03c4\u03bf\u03bc\u03ae\u03c2, \u03bc\u03b5 \u03c4\u03b9\u03c2 \u03bf\u03c0\u03bf\u03af\u03b5\u03c2 \u03b5\u03c0\u03b9\u03c4\u03c5\u03b3\u03c7\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c0\u03b1\u03c1\u03b5\u03bc\u03c0\u03cc\u03b4\u03b9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b4\u03b9\u03ad\u03bb\u03b5\u03c5\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b6\u03c9\u03b1\u03c1\u03af\u03c9\u03bd, \u03c9\u03c3\u03c4\u03cc\u03c3\u03bf \u03bb\u03cc\u03b3\u03c9 \u03c4\u03b7\u03c2 \u03b5\u03bd\u03b1\u03bb\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c4\u03b5\u03c7\u03bd\u03b9\u03ba\u03ae\u03c2 \u03c0\u03bf\u03c5 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03c5\u03c0\u03cc\u03c3\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03b1\u03c7\u03cd\u03c4\u03b5\u03c1\u03b7 \u03b1\u03bd\u03b1\u03c3\u03c4\u03c1\u03b5\u03c8\u03b9\u03bc\u03cc\u03c4\u03b7\u03c4\u03b1. \u03a3\u03c4\u03b9\u03c2 \u03b1\u03bd\u03c9\u03c4\u03ad\u03c1\u03c9 \u03c4\u03b5\u03c7\u03bd\u03b9\u03ba\u03ad\u03c2 \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b7 \u03c7\u03c1\u03ae\u03c3\u03b7 \u03b5\u03bd\u03b4\u03bf\u03b1\u03c5\u03bb\u03b9\u03ba\u03ce\u03bd \u03b2\u03c5\u03c3\u03bc\u03ac\u03c4\u03c9\u03bd \u03b5\u03bd\u03c4\u03cc\u03c2 \u03c4\u03bf\u03c5 \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03b9\u03ba\u03bf\u03cd \u03c0\u03cc\u03c1\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03b7 \u03a5\u03c0\u03cc \u039a\u03b1\u03b8\u03bf\u03b4\u03ae\u03b3\u03b7\u03c3\u03b7 \u0391\u03bd\u03b1\u03c3\u03c4\u03c1\u03ad\u03c8\u03b9\u03bc\u03b7 \u0391\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03bf\u03c5 \u03a3\u03c0\u03ad\u03c1\u03bc\u03b1\u03c4\u03bf\u03c2 (Reversible Inhibition of Sperm Under Guidance &#8211; RISUG) (\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 2).<\/p>\n<hr style=\"width: 100%; border-width: 1px; border-style: solid; border-color: #CCCCCC; color: #ffffff;\" noshade=\"noshade\" width=\"100%\" \/>\n<p style=\"text-align: justify;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-100573\" alt=\"9.11img2\" src=\"https:\/\/e-endocrinology.gr\/wp-content\/uploads\/2015\/09\/9.11img2.jpg\" width=\"408\" height=\"273\" srcset=\"https:\/\/e-endocrinology.gr\/wp-content\/uploads\/2015\/09\/9.11img2.jpg 408w, https:\/\/e-endocrinology.gr\/wp-content\/uploads\/2015\/09\/9.11img2-300x200.jpg 300w\" sizes=\"(max-width: 408px) 100vw, 408px\" \/><\/p>\n<p><b>\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 2.<\/b> \u0391) \u03a0\u03c9\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b5\u03af \u03b7 RISUG: \u03c0\u03bf\u03bb\u03c5\u03bc\u03b5\u03c1\u03ad\u03c2 \u03bc\u03b7\u03bb\u03b5\u03ca\u03bd\u03b9\u03ba\u03bf\u03cd \u03b1\u03bd\u03c5\u03b4\u03c1\u03af\u03c4\u03b7 \u03c4\u03bf\u03c5 \u03c3\u03c4\u03c5\u03c1\u03b5\u03bd\u03af\u03bf\u03c5 \u03b5\u03b3\u03c7\u03ad\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc \u03c0\u03cc\u03c1\u03bf \u03ba\u03b1\u03b9 \u03b4\u03c1\u03b1 \u03c4\u03cc\u03c3\u03bf \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03c0\u03c1\u03cc\u03ba\u03bb\u03b7\u03c3\u03b7 \u03bc\u03b5\u03c1\u03b9\u03ba\u03ae\u03c2 \u03b1\u03c0\u03cc\u03c6\u03c1\u03b1\u03be\u03b7\u03c2 \u03c4\u03c9\u03bd \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03b9\u03ba\u03ce\u03bd \u03c0\u03cc\u03c1\u03c9\u03bd, \u03ba\u03b1\u03b8\u03ce\u03c2 \u03ba\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 \u03bc\u03bf\u03c1\u03c6\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ce\u03bd \u03b1\u03bd\u03c9\u03bc\u03b1\u03bb\u03b9\u03ce\u03bd \u03c3\u03c4\u03b1 \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b6\u03c9\u03ac\u03c1\u03b9\u03b1 \u03c0\u03bf\u03c5 \u03ba\u03b1\u03c4\u03b1\u03c6\u03ad\u03c1\u03bd\u03bf\u03c5\u03bd \u03bd\u03b1 \u03c4\u03bf \u03b4\u03b9\u03b1\u03c0\u03b5\u03c1\u03ac\u03c3\u03bf\u03c5\u03bd. \u0392) \u0395\u03bd\u03b4\u03bf\u03b1\u03c5\u03bb\u03b9\u03ba\u03ac \u03b2\u03cd\u03c3\u03bc\u03b1\u03c4\u03b1.<\/p>\n<hr style=\"width: 100%; border-width: 1px; border-style: solid; border-color: #CCCCCC; color: #ffffff;\" noshade=\"noshade\" width=\"100%\" \/>\n<p>&nbsp;<\/p>\n<p style=\"text-align: justify;\"><b>RISUG<\/b><b>. <\/b>\u0395\u03bd\u03b4\u03b5\u03c7\u03bf\u03bc\u03ad\u03bd\u03c9\u03c2 \u03c0\u03c1\u03cc\u03ba\u03b5\u03b9\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03c0\u03bb\u03ad\u03bf\u03bd \u03c5\u03c0\u03bf\u03c3\u03c7\u03cc\u03bc\u03b5\u03bd\u03b7 \u03b1\u03c0\u03cc \u03b1\u03c5\u03c4\u03ad\u03c2 \u03c4\u03b9\u03c2 \u03c4\u03b5\u03c7\u03bd\u03b9\u03ba\u03ad\u03c2, \u03ba\u03b1\u03b8\u03ce\u03c2 \u03c3\u03b5 \u0399\u03bd\u03b4\u03b9\u03ba\u03cc \u03b1\u03bd\u03b4\u03c1\u03b9\u03ba\u03cc \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03cc \u03ad\u03c7\u03b5\u03b9 \u03b4\u03bf\u03ba\u03b9\u03bc\u03b1\u03c3\u03c4\u03b5\u03af \u03c3\u03b5 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c6\u03ac\u03c3\u03b5\u03b9\u03c2 \u0399 \u03ba\u03b1\u03b9 \u0399\u0399 \u03ba\u03b1\u03b9 \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03c0\u03b1\u03c1\u03ad\u03c7\u03b5\u03b9 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b1\u03bd\u03c4\u03b9\u03c3\u03cd\u03bb\u03bb\u03b7\u03c8\u03b7 \u03ad\u03c9\u03c2 \u03ba\u03b1\u03b9 10 \u03ad\u03c4\u03b7 \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u03b5\u03c6\u03ac\u03c0\u03b1\u03be \u03b5\u03c6\u03b1\u03c1\u03bc\u03bf\u03b3\u03ae.<sup>121<\/sup> \u039a\u03b1\u03c4\u03ac \u03c4\u03b7 RISUG, \u03b4\u03b9\u03ac\u03bb\u03c5\u03bc\u03b1 \u03c4\u03bf\u03c5 \u03bc\u03b7\u03bb\u03b5\u03ca\u03bd\u03b9\u03ba\u03bf\u03cd \u03b1\u03bd\u03c5\u03b4\u03c1\u03af\u03c4\u03b7 \u03c4\u03bf\u03c5 \u03c3\u03c4\u03c5\u03c1\u03b5\u03bd\u03af\u03bf\u03c5 (SMA) \u03c3\u03c4\u03bf \u03b4\u03b9\u03b1\u03bb\u03cd\u03c4\u03b7 \u03b4\u03b9\u03bc\u03b5\u03b8\u03c5\u03bb\u03c3\u03bf\u03c5\u03bb\u03c6\u03bf\u03be\u03b5\u03af\u03b4\u03b9\u03bf (DMSO) \u03b5\u03bd\u03af\u03b5\u03c4\u03b1\u03b9 \u03b5\u03bd\u03c4\u03cc\u03c2 \u03c4\u03bf\u03c5 \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03b9\u03ba\u03bf\u03cd \u03c0\u03cc\u03c1\u03bf\u03c5 \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b1\u03c6\u03b5\u03bd\u03cc\u03c2 \u03c4\u03b7 \u03bc\u03b5\u03c1\u03b9\u03ba\u03ae \u03b1\u03c0\u03cc\u03c6\u03c1\u03b1\u03be\u03ae \u03c4\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03b1\u03c6\u03b5\u03c4\u03ad\u03c1\u03bf\u03c5 \u03c4\u03b7 \u03b2\u03bb\u03ac\u03b2\u03b7 \u03c4\u03c9\u03bd \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b6\u03c9\u03b1\u03c1\u03af\u03c9\u03bd \u03c0\u03bf\u03c5 \u03b4\u03b9\u03ad\u03c1\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03ad\u03c3\u03b1 \u03b1\u03c0\u03cc \u03c4\u03bf \u03c5\u03bb\u03b9\u03ba\u03cc \u03b1\u03c5\u03c4\u03cc (\u03b4\u03b9\u03ac\u03c1\u03c1\u03b7\u03be\u03b7 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae\u03c2 \u03bc\u03b5\u03bc\u03b2\u03c1\u03ac\u03bd\u03b7\u03c2).<sup>122<\/sup> \u0395\u03c6\u03ac\u03c0\u03b1\u03be \u03b4\u03cc\u03c3\u03b7 60mg \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03ac\u03bc\u03b5\u03c3\u03b1 (\u03b5\u03bd\u03c4\u03cc\u03c2 10 \u03b7\u03bc\u03b5\u03c1\u03ce\u03bd), \u03ad\u03c7\u03b5\u03b9 \u03bb\u03af\u03b3\u03b5\u03c2 \u03c0\u03b1\u03c1\u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2, \u03ba\u03b1\u03b9 \u03ad\u03c7\u03b5\u03b9 \u03b1\u03c0\u03bf\u03b4\u03b5\u03b9\u03c7\u03b8\u03b5\u03af \u03c3\u03b5 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u03c5\u03cc\u03bd\u03c4\u03c9\u03bd \u03cc\u03c4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03c1\u03ad\u03c8\u03b9\u03bc\u03b7. \u0395\u03af\u03bd\u03b1\u03b9 \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc \u03cc\u03c4\u03b9 \u03bc\u03b9\u03ba\u03c1\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03b4\u03cc\u03c3\u03b5\u03b9\u03c2 \u03b8\u03b1 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03c3\u03b1\u03bd \u03bd\u03b1 \u03c0\u03b1\u03c1\u03ad\u03c7\u03bf\u03c5\u03bd \u03bc\u03b9\u03ba\u03c1\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03cc\u03b4\u03bf\u03c5\u03c2 \u03b1\u03bd\u03c4\u03b9\u03c3\u03cd\u03bb\u03bb\u03b7\u03c8\u03b7\u03c2. \u03a3\u03c4\u03b9\u03c2 \u03b1\u03bd\u03b5\u03c0\u03b9\u03b8\u03cd\u03bc\u03b7\u03c4\u03b5\u03c2 \u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2 \u03c3\u03c5\u03b3\u03ba\u03b1\u03c4\u03b1\u03bb\u03ad\u03b3\u03b5\u03c4\u03b1\u03b9 \u03b5\u03bb\u03b1\u03c6\u03c1\u03ac \u03b4\u03b9\u03cc\u03b3\u03ba\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03cc\u03c1\u03c7\u03b5\u03c9\u03bd \u03c7\u03c9\u03c1\u03af\u03c2 \u03bd\u03b1 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c0\u03cc\u03bd\u03bf, \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c5\u03c4\u03bf\u03c0\u03b5\u03c1\u03b9\u03bf\u03c1\u03b9\u03b6\u03cc\u03bc\u03b5\u03bd\u03b7 \u03b5\u03bd\u03c4\u03cc\u03c2 15 \u03b7\u03bc\u03b5\u03c1\u03ce\u03bd \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b5\u03c6\u03b1\u03c1\u03bc\u03bf\u03b3\u03ae, \u03b5\u03bd\u03ce \u03b4\u03b5 \u03c3\u03c5\u03bd\u03bf\u03b4\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03ba\u03bf\u03ba\u03ba\u03b9\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ae \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03b7 \u03b1\u03bd\u03c4\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03b5\u03bd \u03b1\u03bd\u03c4\u03b9\u03b8\u03ad\u03c3\u03b5\u03b9 \u03bc\u03b5 \u03c4\u03b7 \u03b2\u03b1\u03b6\u03b5\u03ba\u03c4\u03bf\u03bc\u03ae.<sup>123<\/sup> \u03a5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03b5\u03bd\u03c3\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c3\u03b5 \u03c3\u03c7\u03ad\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b9\u03c2 \u03c0\u03b9\u03b8\u03b1\u03bd\u03ad\u03c2 \u03c4\u03bf\u03be\u03b9\u03ba\u03ad\u03c2 \u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c4\u03bf\u03c5 \u03c5\u03bb\u03b9\u03ba\u03bf\u03cd, \u03c4\u03bf \u03bf\u03c0\u03bf\u03af\u03bf \u03b1\u03c0\u03cc \u03c4\u03bf 2002 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03c6\u03ac\u03c3\u03b7\u03c2 \u0399\u0399\u0399.<sup>124<\/sup><b><\/b><\/p>\n<p style=\"text-align: justify;\"><b>\u0395\u03bd\u03b4\u03bf\u03b1\u03c5\u03bb\u03b9\u03ba\u03ac \u03b2\u03cd\u03c3\u03bc\u03b1\u03c4\u03b1. <\/b>\u0394\u03cd\u03bf \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ac \u03b5\u03af\u03b4\u03b7 \u03b5\u03bd\u03ad\u03c3\u03b9\u03bc\u03c9\u03bd \u03b5\u03bd\u03b4\u03bf\u03b1\u03c5\u03bb\u03b9\u03ba\u03ce\u03bd \u03b2\u03c5\u03c3\u03bc\u03ac\u03c4\u03c9\u03bd \u03ad\u03c7\u03bf\u03c5\u03bd \u03b4\u03bf\u03ba\u03b9\u03bc\u03b1\u03c3\u03c4\u03b5\u03af: \u03b2\u03cd\u03c3\u03bc\u03b1\u03c4\u03b1 \u03c0\u03bf\u03bb\u03c5\u03bf\u03c5\u03c1\u03b5\u03b8\u03ac\u03bd\u03b7\u03c2 (MPU) \u03ba\u03b1\u03b9 \u03b2\u03cd\u03c3\u03bc\u03b1\u03c4\u03b1 \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae\u03c2 \u03c3\u03b9\u03bb\u03b9\u03ba\u03cc\u03bd\u03b7\u03c2 (MSR). \u03a4\u03b1 \u03b2\u03cd\u03c3\u03bc\u03b1\u03c4\u03b1 MPU \u03ad\u03c7\u03bf\u03c5\u03bd \u03b4\u03bf\u03ba\u03b9\u03bc\u03b1\u03c3\u03c4\u03b5\u03af \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c3\u03c4\u03b7\u03bd \u039a\u03af\u03bd\u03b1, \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03b1\u03c1\u03c7\u03ad\u03c2 \u03c4\u03b7\u03c2 \u03b4\u03b5\u03ba\u03b1\u03b5\u03c4\u03af\u03b1\u03c2 \u03c4\u03bf\u03c5 1980, \u03c9\u03c2 \u03b5\u03bd\u03b1\u03bb\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03cc \u03c4\u03b7\u03c2 \u03b2\u03b1\u03b6\u03b5\u03ba\u03c4\u03bf\u03bc\u03ae\u03c2. \u03a3\u03b5 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b7\u03c2 \u03ba\u03bb\u03af\u03bc\u03b1\u03ba\u03b1\u03c2, \u03bc\u03b5 \u03c4\u03b7\u03bd \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03bf\u03bc\u03ac\u03b4\u03b1 \u03bd\u03b1 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03b9 12.000 \u03ac\u03bd\u03b4\u03c1\u03b5\u03c2 \u03b5\u03c0\u03b9\u03c4\u03b5\u03cd\u03c7\u03b8\u03b7\u03ba\u03b5 \u03b1\u03b6\u03c9\u03bf\u03c3\u03c0\u03b5\u03c1\u03bc\u03af\u03b1 \u03c3\u03b5 \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc 98 %.<sup>125<\/sup> \u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03b5\u03c0\u03b9\u03c4\u03b5\u03c5\u03c7\u03b8\u03b5\u03af \u03b1\u03c5\u03c4\u03cc \u03c4\u03bf \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03bf \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03b1\u03c0\u03b1\u03b9\u03c4\u03ae\u03b8\u03b7\u03ba\u03b1\u03bd 18 \u03ad\u03c9\u03c2 24 \u03bc\u03ae\u03bd\u03b5\u03c2. \u03a4\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b1 \u03b2\u03cd\u03c3\u03bc\u03b1\u03c4\u03b1 MSR \u03b4\u03b5\u03bd \u03ae\u03c4\u03b1\u03bd \u03c4\u03cc\u03c3\u03bf \u03b8\u03b5\u03c4\u03b9\u03ba\u03ac, \u03ba\u03b1\u03b8\u03ce\u03c2 \u03c3\u03b5 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c4\u03b1 \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03ac \u03b1\u03b6\u03c9\u03bf\u03c3\u03c0\u03b5\u03c1\u03bc\u03af\u03b1\u03c2 \u03ae\u03c4\u03b1\u03bd 80%, \u03c9\u03c3\u03c4\u03cc\u03c3\u03bf \u03b7 \u03c4\u03bf\u03c0\u03bf\u03b8\u03ad\u03c4\u03b7\u03c3\u03ae \u03c4\u03bf\u03c5\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03c5\u03ba\u03bf\u03bb\u03cc\u03c4\u03b5\u03c1\u03b7 \u03bc\u03b5 \u03c4\u03b7 \u03c7\u03c1\u03ae\u03c3\u03b7 \u03b5\u03b9\u03b4\u03b9\u03ba\u03bf\u03cd \u03b5\u03c6\u03b1\u03c1\u03bc\u03bf\u03b3\u03ad\u03b1.<sup>126<\/sup> \u0395\u03c0\u03b5\u03b9\u03b4\u03ae \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03c4\u03bf\u03c0\u03bf\u03b8\u03ad\u03c4\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b2\u03c5\u03c3\u03bc\u03ac\u03c4\u03c9\u03bd \u03b4\u03b5\u03bd \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03c7\u03b5\u03b9\u03c1\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03ae \u03c4\u03bf\u03bc\u03ae, \u03c4\u03bf \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03b5\u03c0\u03b9\u03c0\u03bb\u03bf\u03ba\u03ce\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03bf \u03b1\u03c0\u03cc \u03b1\u03c5\u03c4\u03cc \u03c4\u03b7\u03c2 \u03b2\u03b1\u03b6\u03b5\u03ba\u03c4\u03bf\u03bc\u03ae\u03c2, \u03c9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03b5\u03ba\u03c6\u03c1\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03bd\u03b7\u03c3\u03c5\u03c7\u03af\u03b5\u03c2 \u03b3\u03b9\u03b1 \u03c0\u03b9\u03b8\u03b1\u03bd\u03ae \u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03c9\u03bd \u03b1\u03c1\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03ce\u03bd \u03b1\u03bc\u03b9\u03bd\u03ce\u03bd \u03c0\u03bf\u03c5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c5\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03cc \u03c4\u03bf\u03c5 \u03c0\u03bf\u03bb\u03c5\u03bc\u03b5\u03c1\u03bf\u03cd\u03c2 MPU. \u03a0\u03ac\u03bd\u03c4\u03c9\u03c2 \u03b7 \u03b5\u03bc\u03c0\u03b5\u03b9\u03c1\u03af\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03c0\u03bf\u03bb\u03c5\u03b5\u03c4\u03ae \u03c7\u03c1\u03ae\u03c3\u03b7 \u03c3\u03c4\u03b7\u03bd \u039a\u03af\u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b8\u03b5\u03c4\u03b9\u03ba\u03ae, \u03c7\u03c9\u03c1\u03af\u03c2 \u03bd\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b1\u03bd\u03b1\u03c6\u03b5\u03c1\u03b8\u03b5\u03af \u03c0\u03b5\u03c1\u03b9\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03ac \u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2.<sup>125<\/sup><\/p>\n<p style=\"text-align: justify;\">\u0397 \u03b1\u03c6\u03b1\u03af\u03c1\u03b5\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b2\u03c5\u03c3\u03bc\u03ac\u03c4\u03c9\u03bd \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af \u03c7\u03b5\u03b9\u03c1\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03ae \u03bc\u03b9\u03ba\u03c1\u03bf\u03b5\u03c0\u03ad\u03bc\u03b2\u03b1\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03bf\u03c0\u03b9\u03ba\u03ae \u03b1\u03bd\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03af\u03b1 \u03c3\u03b5 \u03b5\u03be\u03c9\u03bd\u03bf\u03c3\u03bf\u03ba\u03bf\u03bc\u03b5\u03b9\u03b1\u03ba\u03ae \u03b2\u03ac\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03b5\u03c0\u03b1\u03bd\u03b1\u03c6\u03bf\u03c1\u03ac\u03c2 \u03c4\u03b7\u03c2 \u03b3\u03bf\u03bd\u03b9\u03bc\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03c4\u03ac\u03be\u03b7\u03c2 \u03c4\u03bf\u03c5 85% \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u03c0\u03ad\u03bd\u03c4\u03b5 \u03ad\u03c4\u03b7 \u03b5\u03c6\u03b1\u03c1\u03bc\u03bf\u03b3\u03ae\u03c2. \u0395\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd, \u03b8\u03b5\u03c9\u03c1\u03b7\u03c4\u03b9\u03ba\u03ac \u03ad\u03c7\u03b5\u03b9 \u03c4\u03bf \u03c0\u03bb\u03b5\u03bf\u03bd\u03ad\u03ba\u03c4\u03b7\u03bc\u03b1 \u03c4\u03b7\u03c2 \u03b4\u03c5\u03bd\u03b1\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03b5\u03c0\u03b1\u03bd\u03ac\u03bb\u03b7\u03c8\u03b7\u03c2 \u03bc\u03b5 \u03b1\u03c6\u03b1\u03af\u03c1\u03b5\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b5\u03c0\u03b1\u03bd\u03b1\u03c4\u03bf\u03c0\u03bf\u03b8\u03ad\u03c4\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b2\u03c5\u03c3\u03bc\u03ac\u03c4\u03c9\u03bd \u03c7\u03c9\u03c1\u03af\u03c2 \u03bf\u03c5\u03c3\u03b9\u03ce\u03b4\u03b5\u03b9\u03c2 \u03b2\u03bb\u03ac\u03b2\u03b5\u03c2. \u2018\u038c\u03c0\u03c9\u03c2 \u03c3\u03c5\u03bc\u03b2\u03b1\u03af\u03bd\u03b5\u03b9 \u03ba\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03ad\u03bd\u03b1\u03c1\u03be\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2, \u03b7 \u03b1\u03bd\u03c4\u03b9\u03c3\u03c4\u03c1\u03bf\u03c6\u03ae \u03c4\u03b7\u03c2 \u03b1\u03bd\u03c4\u03b9\u03c3\u03c5\u03bb\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03b4\u03c1\u03ac\u03c3\u03b7\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c1\u03b3\u03ae \u03b1\u03bb\u03bb\u03ac \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03ae \u03ba\u03b1\u03b9 \u03b5\u03c0\u03b9\u03c4\u03c5\u03b3\u03c7\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 2 \u03bc\u03b5 4 \u03ad\u03c4\u03b7.<sup>127<\/sup><\/p>\n<h4 style=\"text-align: justify;\">5. \u039c\u03b5\u03bb\u03bb\u03bf\u03bd\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03c1\u03bf\u03c3\u03b5\u03b3\u03b3\u03af\u03c3\u03b5\u03b9\u03c2<\/h4>\n<p style=\"text-align: justify;\">\u03a4\u03b1 \u03b3\u03bb\u03c5\u03ba\u03bf\u03c3\u03c6\u03b9\u03b3\u03b3\u03bf\u03bb\u03b9\u03c0\u03af\u03b4\u03b9\u03b1 \u03b5\u03ba\u03c6\u03c1\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b1\u03c6\u03b8\u03bf\u03bd\u03af\u03b1 \u03c3\u03c4\u03b1 \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b6\u03c9\u03ac\u03c1\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03c0\u03bf\u03bd\u03c4\u03af\u03ba\u03b9\u03b1 \u03bc\u03b5 \u03ad\u03bb\u03bb\u03b5\u03b9\u03c8\u03b7 \u03b5\u03bd\u03b6\u03cd\u03bc\u03c9\u03bd \u03c0\u03bf\u03c5 \u03b5\u03bc\u03c0\u03bb\u03ad\u03ba\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03b2\u03b9\u03bf\u03c3\u03cd\u03bd\u03b8\u03b5\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03bf \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03c3\u03bc\u03cc \u03b3\u03bb\u03c5\u03ba\u03bf\u03c3\u03c6\u03b9\u03b3\u03b3\u03bf\u03bb\u03b9\u03c0\u03b9\u03b4\u03af\u03c9\u03bd \u03ad\u03c7\u03bf\u03c5\u03bd \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03b3\u03bf\u03bd\u03b9\u03bc\u03cc\u03c4\u03b7\u03c4\u03b1. \u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03bc\u03b9\u03b3\u03bb\u03bf\u03c5\u03c3\u03c4\u03ac\u03c4\u03b7\u03c2, \u03b5\u03bd\u03cc\u03c2 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03b1 \u03c4\u03b7\u03c2 \u03c3\u03cd\u03bd\u03b8\u03b5\u03c3\u03b7\u03c2 \u03b3\u03bb\u03c5\u03ba\u03bf\u03c3\u03c6\u03b9\u03b3\u03b3\u03bf\u03bb\u03b9\u03c0\u03af\u03b4\u03b9\u03c9\u03bd \u03c3\u03b5 \u03c5\u03b3\u03b9\u03b5\u03af\u03c2 \u03ac\u03bd\u03b4\u03c1\u03b5\u03c2, \u03b4\u03b5\u03bd \u03b5\u03af\u03c7\u03b5 \u03ba\u03b1\u03bc\u03af\u03b1 \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c3\u03c4\u03b7 \u03b3\u03bf\u03bd\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03ae \u03b9\u03ba\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03c9\u03bd \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b6\u03c9\u03b1\u03c1\u03af\u03c9\u03bd.<\/p>\n<p style=\"text-align: justify;\">\u0395\u03c0\u03b9\u03c0\u03c1\u03cc\u03c3\u03b8\u03b5\u03c4\u03b1, \u03c3\u03c4\u03b1 \u03c0\u03b9\u03bf \u03c0\u03c1\u03cc\u03c3\u03c6\u03b1\u03c4\u03b1 \u03c0\u03b5\u03b9\u03c1\u03ac\u03bc\u03b1\u03c4\u03b1 \u03c3\u03c5\u03b3\u03ba\u03b1\u03c4\u03b1\u03bb\u03ad\u03b3\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03c4\u03b7\u03c2 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03bc\u03b9\u03ba\u03c1\u03bf\u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03bf\u03cd \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03b1 JQ1 \u03c4\u03b7\u03c2 \u03b5\u03b9\u03b4\u03b9\u03ba\u03ae\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03cc\u03c1\u03c7\u03b9 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2 bromodomain BRDT.<sup>128<\/sup> H BRDT \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03af\u03b1 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 \u03b5\u03bc\u03c0\u03bb\u03b5\u03ba\u03cc\u03bc\u03b5\u03bd\u03b7 \u03c3\u03c4\u03b7 \u03c7\u03c9\u03c1\u03bf\u03b4\u03b9\u03ac\u03c4\u03b1\u03be\u03b7 \u03c4\u03c9\u03bd \u03b9\u03c3\u03c4\u03bf\u03bd\u03ce\u03bd \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b1\u03bd\u03b1\u03b4\u03af\u03c0\u03bb\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c7\u03c1\u03c9\u03bc\u03b1\u03c4\u03af\u03bd\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03c0\u03b1\u03bd\u03c4\u03ac\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b1 \u03bc\u03b5\u03b9\u03c9\u03c4\u03b9\u03ba\u03ac \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b9\u03c2 \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03af\u03b4\u03b5\u03c2. \u03a7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03b1 JQ1 \u03c3\u03b5 \u03c0\u03bf\u03bd\u03c4\u03af\u03ba\u03b9\u03b1 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af \u03b1\u03bd\u03b1\u03c3\u03c4\u03c1\u03ad\u03c8\u03b9\u03bc\u03b7 \u03c3\u03c4\u03b5\u03b9\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1. \u0394\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03bf\u03bc\u03bf\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c4\u03b7\u03c2 BRDT \u03c4\u03bf\u03c5 \u03c0\u03bf\u03bd\u03c4\u03b9\u03ba\u03bf\u03cd \u03bc\u03b5 \u03b1\u03c5\u03c4\u03ae\u03bd \u03c4\u03bf\u03c5 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03bf\u03c5, \u03b8\u03b1 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03c3\u03b5 \u03bd\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03b5\u03b9 \u03b1\u03bd\u03c4\u03b9\u03c3\u03c5\u03bb\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03ae \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf \u03ba\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03ac\u03bd\u03b4\u03c1\u03b1.<\/p>\n<p style=\"text-align: justify;\">\u03a0\u03b1\u03c1\u2019 \u03cc\u03bb\u03b7 \u03c4\u03b7\u03bd \u03c0\u03c1\u03cc\u03bf\u03b4\u03bf \u03c3\u03c4\u03b7\u03bd \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03ce\u03bd \u03bf\u03c1\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03c4\u03b9\u03c3\u03cd\u03bb\u03bb\u03b7\u03c8\u03b7\u03c2, \u03b7 \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 \u03c4\u03b7\u03c2 \u03b5\u03c0\u03b9\u03c3\u03c4\u03ae\u03bc\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u03bf\u03bc\u03b9\u03ba\u03ae\u03c2 \u03b8\u03ad\u03c4\u03b5\u03b9 \u03c4\u03b9\u03c2 \u03b2\u03ac\u03c3\u03b5\u03b9\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03bd\u03b1\u03ba\u03ac\u03bb\u03c5\u03c8\u03b7 \u03bd\u03ad\u03c9\u03bd \u03c3\u03c4\u03cc\u03c7\u03c9\u03bd \u03b5\u03c0\u03af \u03c4\u03c9\u03bd \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b6\u03c9\u03b1\u03c1\u03af\u03c9\u03bd \u03b3\u03b9\u03b1 \u03c0\u03b9\u03bf \u03b5\u03ba\u03bb\u03b5\u03ba\u03c4\u03b9\u03ba\u03ae \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03ce\u03c0\u03b9\u03c3\u03b7. \u03a4\u03bf \u03b3\u03b5\u03b3\u03bf\u03bd\u03cc\u03c2 \u03cc\u03c4\u03b9 \u03c4\u03b1 \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b6\u03c9\u03ac\u03c1\u03b9\u03b1 \u03c3\u03b5 \u03c3\u03c7\u03ad\u03c3\u03b7 \u03bc\u03b5 \u03ac\u03bb\u03bb\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03bb\u03bf\u03cd\u03c3\u03b9\u03b1 \u03c3\u03b5 \u03bc\u03b5\u03bc\u03b2\u03c1\u03b1\u03bd\u03b9\u03ba\u03ad\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2, \u03c3\u03b5 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b1\u03bd\u03b9\u03ba\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03ac \u03c4\u03bf\u03c5\u03c2 \u03bd\u03b1 \u03c0\u03c1\u03bf\u03b2\u03bf\u03cd\u03bd \u03c3\u03b5 \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03bf\u03c3\u03cd\u03bd\u03b8\u03b5\u03c3\u03b7 \u03c0\u03ad\u03c1\u03b1\u03bd \u03c4\u03bf\u03c5 \u03c3\u03c4\u03b1\u03b4\u03af\u03bf\u03c5 \u03c4\u03b7\u03c2 \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03af\u03b4\u03b1\u03c2 \u03c4\u03b1 \u03ba\u03b1\u03b8\u03b9\u03c3\u03c4\u03ac \u03ac\u03c1\u03b9\u03c3\u03c4\u03bf\u03c5\u03c2 \u03c3\u03c4\u03cc\u03c7\u03bf\u03c5\u03c2 \u03b3\u03b9\u03b1 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03c4\u03bf\u03c5 \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03b9\u03ba\u03bf\u03cd profil \u03c4\u03bf\u03c5\u03c2.<sup>129<\/sup><\/p>\n<h4 style=\"text-align: justify;\">\u0392\u03b9\u03b2\u03bb\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1<\/h4>\n<p style=\"text-align: justify;\">1. 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